Vaccine production ultracentrifugation device with internal cleaning function

Abstract

The invention discloses an ultracentrifugal device with an internal cleaning function for vaccine production, and relates to the technical field of centrifugal devices.The ultracentrifugal device is characterized in that an operator puts a pipe filled with vaccines into a rotor of a centrifugal rotating mechanism of a centrifugal cavity, and a vacuum pump extracts gas in the centrifugal cavity; the motor drives the rotor to conduct centrifugal separation on a pipe filled with vaccines at a high speed, meanwhile, cooling is conducted through the cooling mechanism, denaturation or inactivation of a sample caused by friction heat generated by high-speed centrifugation is prevented, and it is ensured that the separation environment is stable. The inner wall of the centrifugal cavity is cleaned at a low rotating speed, so that the interior of the centrifugal cavity is cleaned, and sewage generated by cleaning is discharged through the drainage mechanism, so that residual materials are prevented from polluting subsequent vaccine production batches, and the vaccine quality is ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of centrifugal devices, and specifically to an ultra-high speed centrifugal device for vaccine production with an internal cleaning function. Background Art

[0002] In existing or traditional ultra-high speed centrifugal devices, during the production of vaccines, after centrifugally separating the vaccines, the rotor and cavity components are usually manually disassembled, and a brush and cleaning agent are used to wipe and clean the inner wall of the centrifugal cavity. Manual cleaning often fails to thoroughly remove the residues on the inner wall of the centrifugal cavity, which may then contaminate the subsequent vaccines produced.

[0003] When manually cleaning the inside of the ultra-high speed centrifugal device, it is usually necessary to stop the machine. Wait for the ultra-high speed centrifugal device to decelerate and completely cool down, and then manually disassemble the rotor and cavity components, resulting in a relatively long time required. This leads to a relatively long time for a single cleaning cycle, seriously affecting the efficiency of vaccine production. Moreover, when manually disassembling and cleaning, if the operator operates improperly, it may cause situations such as liquid splashing, which may cause the operator to be infected or contaminants to remain in the centrifugal cavity, resulting in contamination of subsequent vaccine production batches. Summary of the Invention

[0004] The purpose of the present invention is to provide an ultra-high speed centrifugal device for vaccine production with an internal cleaning function to solve the problems raised in the prior art.

[0005] To achieve the above purpose, the present invention provides the following technical solutions: An ultra-high speed centrifugal device for vaccine production with an internal cleaning function, the centrifugal device includes a first housing, a centrifugal rotation mechanism, an adaptive cleaning mechanism, a cooling mechanism, a vacuum mechanism, a drainage mechanism, and a centrifugal cavity. The first housing is fixedly connected to the centrifugal cavity, the centrifugal rotation mechanism is fixedly connected to the centrifugal cavity, the adaptive cleaning mechanism is fixedly connected to the centrifugal rotation mechanism, the cooling mechanism is fixedly connected to the centrifugal cavity, the vacuum mechanism is connected to the centrifugal cavity through a pipeline, and the drainage mechanism is fixedly connected to the centrifugal cavity.

[0006] By using the first housing as the installation basis for each mechanism, providing a stable working environment for each mechanism, the operator places the tube containing the vaccine on the centrifugal rotation mechanism in the centrifugal cavity, extracts the gas in the centrifugal cavity through the vacuum mechanism, and through the centrifugal rotation mechanism, rotates at high speed to separate the vaccine sample in the tube containing the vaccine. At the same time, it is cooled through the cooling mechanism to prevent the sample from denaturing or inactivating due to the frictional heat generated by high-speed centrifugation, ensuring a stable separation environment. Through the low-speed operation of the centrifugal rotation mechanism, the adaptive cleaning mechanism cleans the inner wall of the centrifugal cavity, thereby cleaning the inside of the centrifugal cavity, and discharging the sewage generated by the cleaning through the drainage mechanism, thereby preventing the residual materials from contaminating subsequent vaccine production batches and ensuring the quality of the vaccines.

[0007] Furthermore, the centrifugal rotation mechanism includes a motor, a rotating shaft, a base, and a rotor. The motor is fixedly connected to the centrifugal chamber. The output end of the motor is fixedly connected to the rotating shaft. The rotating shaft is fixedly connected to the base. The rotor is tightly connected to the base.

[0008] Through the motor fixed outside the centrifugal chamber, with the output end of the motor fixed to the rotating shaft, the motor drives the rotating shaft to rotate. The rotating shaft drives the base to rotate, and the base drives the rotor mounted thereon to rotate, thereby centrifugally separating the tubes containing vaccines on the rotor.

[0009] Furthermore, the adaptive cleaning mechanism includes a centrifugal contraction unit, a connecting rod, a spraying unit, a fixed rod, an adjusting mechanism, a scraper, and a brush. The rotor is provided with a movable groove. The centrifugal contraction unit is placed in the movable groove. The connecting rod is fixedly connected to the centrifugal contraction unit. The spraying unit is fixedly connected to the connecting rod. The fixed rod is fixedly connected to the connecting rod. The adjusting mechanism is fixedly connected to the fixed rod. The scraper is slidably connected to the adjusting mechanism. The brush is rotatably connected to the fixed rod.

[0010] Through the centrifugal contraction unit, when the rotor rotates at a high speed, the connecting rod and the components mounted thereon contract towards the movable groove of the rotor, causing the fixed rod and the spraying unit to be respectively inserted into two reserved grooves of the rotor, thereby reducing the air resistance during high-speed rotation, reducing the energy consumption of the motor. At the same time, it avoids additional heat generation caused by the exposure of components, which affects the activity of the sample. When the rotor rotates at a low speed, the centrifugal contraction unit resets, causing the connecting rod and the components mounted thereon to pop out. The inner wall of the centrifugal chamber is cleaned by the scraper and the brush on the fixed rod. The spraying unit sprays cleaning liquid to wash and moisten the sample residues on the inner wall of the centrifugal chamber, reducing the hardness and adhesion of the residues, making it easier for the scraper and the brush to clean the residues on the inner wall of the centrifugal chamber. Through the adjusting mechanism, the contact pressure between the scraper and the inner wall of the centrifugal chamber is adjusted to control the scraping force on stubborn residues, avoiding excessive scraping force that may damage the surface of the cavity, and adjusting the flow rate of the spraying unit, thereby realizing the combined cleaning of scraping and flushing to ensure the efficient removal of stubborn stains.

[0011] Furthermore, the centrifugal contraction unit includes an annular spring, a counterweight slider, and a transmission rod. The rotor is provided with an annular groove. The annular spring is placed in the annular groove. The counterweight slider is fixedly connected to the annular spring. The transmission rod is fixedly connected to the counterweight slider. The transmission rod is fixedly connected to the connecting rod. The transmission rod is hinged to the rotor. The counterweight slider is slidably connected to the annular groove.

[0012] By arranging an annular spring and a counterweight slider in the annular groove of the rotor, when the rotor rotates at a high speed, the counterweight slider overcomes the tensile force of the annular spring under the action of centrifugal force, the annular spring is stretched, and the counterweight slider slides along the annular groove, so that the counterweight slider pushes the transmission rod. The transmission rod first rotates slowly along the hinge and then rotates quickly, avoiding excessive impact force during contraction and causing damage to the cleaning components. The torsion spring arranged on the transmission rod hinge is compressed, and then the transmission rod contracts into the movable groove. When the rotor rotates at a low speed, the annular spring contracts, the counterweight slider slides along the annular groove to reset, and at the same time the torsion spring releases elastic force, so that the transmission rod rotates along the hinge to reset.

[0013] Further, the spraying unit includes a water pump, a rotary joint, a cleaning liquid tank and a spray pipe. The water pump is connected to the rotary joint through a pipeline, the cleaning liquid tank is connected to the water pump through a pipeline, the spray pipe is connected to the rotary joint through a pipeline, and the spray pipe is fixedly connected to the connecting rod.

[0014] Through the water pump, the cleaning liquid in the cleaning liquid tank is pumped into the rotary joint through the pipeline. The rotary joint is connected to the spray pipe through the pipeline inside the rotor, so that the cleaning liquid flows into the spray pipe, and the cleaning liquid sprays out from the water outlet of the spray pipe. The water outlet of the spray pipe faces the scraper, thereby flushing the inner wall of the centrifugal chamber and reducing the hardness and adhesion of the residue.

[0015] Further, the adjusting mechanism includes a first spring, a guide rod, a piezoelectric ceramic and an electrode. The first spring is sleeved outside the guide rod. The guide rod is fixedly connected to the fixed rod. The guide rod is slidably connected to the scraper. The piezoelectric ceramic is fixedly connected to the fixed rod. The first spring abuts against the piezoelectric ceramic. The electrode is fixedly connected to the piezoelectric ceramic.

[0016] By installing the scraper on the guide rod, the scraper can slide along the guide rod. However, when encountering contaminants with different viscosities, the scraper can overcome the elastic force of the first spring and slide along the guide rod, so that the scraper fits more closely to the inner wall of the centrifugal chamber, increasing the contact area with the contaminants, thereby increasing the scraping force on the contaminants. A piezoelectric ceramic is installed at the bottom in the compression direction of the first spring. When the first spring is compressed, the pressure of the piezoelectric ceramic changes, causing it to generate a piezoelectric effect to generate current. The current passes through the electrode fixed to the piezoelectric ceramic, and the electrode is connected to the control system of the centrifugal device through an electrical signal, so that the control system controls the water pump according to the current generated by the piezoelectric ceramic, thereby controlling the flow rate of the cleaning liquid.

[0017] Further, the first spring includes a variable pitch helical section and a variable diameter helical section. The variable pitch helical section is fixedly connected to the scraper. The variable pitch helical section is fixedly connected to the variable diameter helical section. The variable diameter helical section is fixedly connected to the fixed rod.

[0018] The first spring is provided with two sections: a variable pitch helical section and a variable diameter helical section. During low-speed rotary cleaning, the variable pitch helical section and the scraper are fixed, enabling the scraper to adapt to materials with different viscosities. When cleaning high-viscosity contaminants, a greater contact force is provided; when cleaning low-viscosity contaminants, a smaller contact force is provided, preventing unclean cleaning or excessive wear on the inner wall of the centrifugal chamber. Through the variable diameter helical section, a greater elastic support force is provided to limit the displacement of the scraper during high-speed rotation and avoid damage to the adjustment structure caused by excessive centrifugal force.

[0019] Furthermore, the drainage mechanism includes a drain pipe, an electromagnetic coil, a return spring, and a sliding piece. The drain pipe is fixedly connected to the centrifugal chamber. The drain pipe is provided with a liquid passage. The electromagnetic coil is fixedly connected to the liquid passage. The return spring is fixedly connected to the liquid passage. The sliding piece is slidably connected to the liquid passage and fixedly connected to the return spring.

[0020] By installing an electromagnetic coil in the drain pipe, a magnetic force is generated in the electromagnetic coil passage. Since the sliding piece is made of metal, the sliding piece overcomes the elastic force of the return spring and slides along the liquid passage towards the electromagnetic coil, connecting the drain pipe to the external pipe, thereby draining the liquid in the centrifugal chamber. When the centrifugal device is working, the electromagnetic coil is powered off, and the return spring releases its elastic force, causing the sliding piece to slide upward to seal the drain pipe and prevent air leakage.

[0021] Furthermore, the vacuum mechanism includes a vacuum pump, a second housing, a second spring, and a sealing cover. The vacuum pump is connected to the centrifugal chamber through a pipe. The second housing is connected to the vacuum pump through a pipe. The second spring is fixedly connected to the second housing. The sealing cover is fixedly connected to the second spring and abuts against the second housing.

[0022] By connecting the vacuum pump to the internal pipe of the centrifugal chamber, the vacuum pump can extract the gas inside the centrifugal chamber. By connecting the gas output end of the vacuum pump to the internal pipe of the second housing, the gas is discharged through the second housing. By providing a second spring and a sealing cover at the outlet of the second housing, when gas needs to be discharged, the second spring is stretched by the force, causing the sealing cover to slide upward, thus connecting the second housing to the outside. When the vacuum pump stops operating, the second spring pulls the sealing cover to seal the outlet of the second housing and prevent air leakage.

[0023] Furthermore, the cooling mechanism includes a cooling module, an outlet pipe, and a return pipe. The cooling module is fixedly connected to the first housing. The outlet pipe is fixedly connected to the cooling module. The return pipe is fixedly connected to the cooling module. The outlet pipe is connected to the centrifugal chamber, and the return pipe is connected to the centrifugal chamber.

[0024] A small amount of cooling gas is input into the centrifugal chamber through the air outlet pipe by the cooling module, so as to cool the inside of the centrifugal chamber, prevent the rotor from generating heat during high-speed rotation, which may cause the vaccine sample to denature or inactivate. The gas inside the centrifugal chamber is extracted through the return air pipe, cooled in the cooling module, and then re-input into the centrifugal chamber through the air outlet pipe, so as to continuously cool the inside of the centrifugal chamber.

[0025] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. Through the self-adaptive cleaning mechanism integrated on the rotor, after a single centrifugal separation, the inner wall of the centrifugal chamber can be cleaned without stopping the machine waiting for the ultra-high speed centrifuge to decelerate to complete cooling, thus reducing the cleaning time required, improving production efficiency, and at the same time avoiding the pollution of the vaccines produced subsequently caused by improper manual operation.

[0026] 2. Through the centrifugal contraction unit, when the rotor rotates at high speed, the cleaning components contract into the rotor interior or the reserved grooves, reducing the air resistance during high-speed rotation, lowering the motor energy consumption. At the same time, it avoids the additional heat generated due to the exposure of the components, which affects the sample activity.

[0027] 3. Through the adjustment unit, the scraper automatically adjusts the scraping force according to pollutants with different viscosities, thereby reducing the wear of the scraper on the inside of the centrifugal chamber and increasing the service life of the equipment. Through the piezoelectric ceramics, different currents are generated according to the change of the spring's elastic force, enabling the control system to precisely control the flow rate of the cleaning liquid and reducing the waste of the cleaning liquid.

[0028] 4. Through the cooperation of the vacuum mechanism and the cooling mechanism, the temperature of the vaccine during centrifugal separation is controlled, avoiding the denaturation or inactivation of the vaccine caused by the frictional heat generated during high-speed centrifugation. Brief Description of the Drawings

[0029] Figure 1 It is a schematic structural diagram of the overall invention; Figure 2 It is a schematic structural diagram of the centrifugal rotation mechanism of the present invention; Figure 3 It is a schematic structural diagram of the spraying unit of the present invention; Figure 4 It is a schematic structural diagram of the rotor of the present invention; Figure 5 It is a schematic structural diagram of the centrifugal contraction unit of the present invention; Figure 6 is Figure 5 the enlarged view of the partial A of Figure 7 It is a schematic structural diagram of the annular spring of the present invention; Figure 8 It is a schematic connection diagram of the piezoelectric ceramics of the present invention; Figure 9Schematic diagram of the first spring of the present invention; Figure 10 Schematic diagram of the drainage mechanism of the present invention; Figure 11 Schematic diagram of the second housing of the present invention; Figure 12 Schematic diagram of the cooling mechanism of the present invention.

[0030] In the figure: 1. First housing; 2. Centrifugal rotation mechanism; 21. Motor; 22. Rotating shaft; 23. Base; 24. Rotor; 241. Movable groove; 242. Annular groove; 3. Adaptive cleaning mechanism; 31. Centrifugal contraction unit; 311. Annular spring; 312. Counterweight slider; 313. Transmission rod; 32. Connecting rod; 33. Spraying unit; 331. Water pump; 332. Rotary joint; 333. Cleaning liquid water tank; 334. Spraying pipe; 34. Fixed rod; 35. Adjusting mechanism; 351. First spring; 3511. Variable pitch helical section; 3512. Variable diameter helical section; 352. Guide rod; 353. Piezoelectric ceramic; 354. Electrode; 36. Scraper; 37. Brush; 4. Cooling mechanism; 41. Cooling module; 42. Air outlet pipe; 43. Return air pipe; 5. Vacuum mechanism; 51. Vacuum pump; 52. Second housing; 53. Second spring; 54. Sealing cover; 6. Drainage mechanism; 61. Drain pipe; 611. Liquid channel; 62. Electromagnetic coil; 63. Return spring; 64. Slide; 7. Centrifugal chamber. Detailed implementation manners

[0031] Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0032] Embodiment: As Figures 1 - 3 shown, the present invention provides a technical solution for an ultra-high speed centrifuge for vaccine production with an internal cleaning function. An ultra-high speed centrifuge for vaccine production with an internal cleaning function includes a first housing 1, a centrifugal rotation mechanism 2, an adaptive cleaning mechanism 3, a cooling mechanism 4, a vacuum mechanism 5, a drainage mechanism 6 and a centrifugal chamber 7. The first housing 1 is fixedly connected to the centrifugal chamber 7, the centrifugal rotation mechanism 2 is fixedly connected to the centrifugal chamber 7, the adaptive cleaning mechanism 3 is fixedly connected to the centrifugal rotation mechanism 2, the cooling mechanism 4 is fixedly connected to the centrifugal chamber 7, the vacuum mechanism 5 is connected to the centrifugal chamber 7 through a pipeline, and the drainage mechanism 6 is fixedly connected to the centrifugal chamber 7.

[0033] By using the first outer shell 1 as the installation base for each mechanism to provide a stable working environment for each mechanism, the operator places the tube containing the vaccine on the centrifugal rotation mechanism 2 in the centrifugal chamber 7, extracts the gas in the centrifugal chamber 7 through the vacuum mechanism 5, and through the centrifugal rotation mechanism 2, rotates at high speed to separate the vaccine samples in the tube containing the vaccine. At the same time, it is cooled by the cooling mechanism 4 to prevent the samples from denaturing or inactivating due to the frictional heat generated by high-speed centrifugation, ensuring a stable separation environment. By rotating the centrifugal rotation mechanism 2 at a low speed, the adaptive cleaning mechanism 3 cleans the inner wall of the centrifugal chamber 7, thereby cleaning the inside of the centrifugal chamber 7, and discharging the sewage generated by cleaning through the drainage mechanism 6, thereby preventing the residual materials from contaminating the subsequent vaccine production batches and ensuring the vaccine quality.

[0034] As Figure 2 shown, the centrifugal rotation mechanism 2 includes a motor 21, a rotating shaft 22, a base 23, and a rotor 24. The motor 21 is fixedly connected to the centrifugal chamber 7, the output end of the motor 21 is fixedly connected to the rotating shaft 22, the rotating shaft 22 is fixedly connected to the base 23, and the rotor 24 is firmly connected to the base 23.

[0035] Through the motor 21 fixed outside the centrifugal chamber 7, the output end of the motor 21 is fixed to the rotating shaft 22, so that the motor 21 drives the rotating shaft 22 to rotate. The rotating shaft 22 drives the base 23 to rotate, and the base 23 drives the rotor 24 mounted thereon to rotate, thereby performing centrifugal separation on the tube containing the vaccine on the rotor 24.

[0036] As Figures 4 - 6 shown, the adaptive cleaning mechanism 3 includes a centrifugal contraction unit 31, a connecting rod 32, a spraying unit 33, a fixing rod 34, an adjusting mechanism 35, a scraper 36, and a brush 37. The rotor 24 is provided with a movable groove 241. The centrifugal contraction unit 31 is placed in the movable groove 241. The connecting rod 32 is fixedly connected to the centrifugal contraction unit 31. The spraying unit 33 is fixedly connected to the connecting rod 32. The fixing rod 34 is fixedly connected to the connecting rod 32. The adjusting mechanism 35 is fixedly connected to the fixing rod 34. The scraper 36 is slidably connected to the adjusting mechanism 35. The brush 37 is rotatably connected to the fixing rod 34.

[0037] Through the centrifugal contraction unit 31, when the rotor 24 rotates at high speed, the connecting rod 32 and the components mounted thereon are contracted towards the movable groove 241 of the rotor 24, so that the fixed rod 34 and the spraying unit 33 are respectively embedded into the two reserved grooves of the rotor 24, thereby reducing the air resistance during high-speed rotation, reducing the energy consumption of the motor 21. At the same time, it avoids the additional heat generated due to the exposure of the components, which affects the activity of the sample. When the rotor 24 rotates at low speed, the centrifugal contraction unit 31 resets, causing the connecting rod 32 and the components mounted thereon to pop out. The inner wall of the centrifugal chamber 7 is cleaned by the scraper 36 and the brush 37 on the fixed rod 34, and the cleaning liquid is sprayed by the spraying unit 33 to wash and moisten the sample residues on the inner wall of the centrifugal chamber 7, reducing the hardness and adhesion of the residues, making it easier for the scraper 36 and the brush 37 to clean the residues on the inner wall of the centrifugal chamber 7. Through the adjusting mechanism 35, the contact pressure between the scraper 36 and the inner wall of the centrifugal chamber 7 is adjusted to control the scraping force of the scraper 36 on stubborn residues, avoiding excessive scraping force that may damage the surface of the chamber, and adjusting the flow rate of the spraying unit 33, so as to achieve the combined cleaning of scraping and rinsing and ensure the efficient removal of stubborn stains.

[0038] As Figure 5 and Figure 7 shown, the centrifugal contraction unit 31 includes an annular spring 311, a counterweight slider 312 and a transmission rod 313. The rotor 24 is provided with an annular groove 242. The annular spring 311 is placed in the annular groove 242. The counterweight slider 312 is fixedly connected to the annular spring 311. The transmission rod 313 is fixedly connected to the counterweight slider 312. The transmission rod 313 is fixedly connected to the connecting rod 32. The transmission rod 313 is hinged to the rotor 24. The counterweight slider 312 is slidably connected to the annular groove 242.

[0039] By arranging the annular spring 311 and the counterweight slider 312 in the annular groove 242 of the rotor 24, when the rotor 24 rotates at high speed, the counterweight slider 312 overcomes the pulling force of the annular spring 311 under the action of centrifugal force, the annular spring 311 is stretched, and the counterweight slider 312 slides along the annular groove 242, so that the counterweight slider 312 pushes the transmission rod 313. The transmission rod 313 first rotates slowly along the hinge and then rotates quickly, avoiding excessive impact force during contraction and damaging the cleaning components. The torsion spring provided at the hinge of the transmission rod 313 is compressed, and then the transmission rod 313 is contracted into the movable groove 241. When the rotor 24 rotates at low speed, the annular spring 311 contracts, the counterweight slider 312 slides along the annular groove 242 to reset, and at the same time the torsion spring releases elastic force, causing the transmission rod 313 to rotate along the hinge for reset.

[0040] As Figures 2 - 4As shown in the figure, the spraying unit 33 includes a water pump 331, a rotary joint 332, a cleaning liquid tank 333, and a spray pipe 334. The water pump 331 and the rotary joint 332 are connected by a pipeline. The cleaning liquid tank 333 and the water pump 331 are connected by a pipeline. The spray pipe 334 and the rotary joint 332 are connected by a pipeline. The spray pipe 334 is fixedly connected to the connecting rod 32.

[0041] Through the water pump 331, the cleaning liquid in the cleaning liquid tank 333 is pumped into the rotary joint 332 through the pipeline. Through the rotary joint 332, it is connected to the spray pipe 334 through the pipeline inside the rotor 24, so that the cleaning liquid flows into the spray pipe 334, and the cleaning liquid is sprayed out from the water outlet of the spray pipe 334. The water outlet of the spray pipe 334 faces the scraper 36, thereby flushing the inner wall of the centrifugal chamber 7 and reducing the hardness and adhesion of the residue.

[0042] As Figure 6 and Figure 8 shown in the figure, the adjusting mechanism 35 includes a first spring 351, a guide rod 352, a piezoelectric ceramic 353, and an electrode 354. The first spring 351 is sleeved outside the guide rod 352. The guide rod 352 is fixedly connected to the fixed rod 34. The guide rod 352 is slidably connected to the scraper 36. The piezoelectric ceramic 353 is fixedly connected to the fixed rod 34. The first spring 351 abuts against the piezoelectric ceramic 353. The electrode 354 is fixedly connected to the piezoelectric ceramic 353.

[0043] By installing the scraper 36 on the guide rod 352, the scraper 36 can slide along the guide rod 352. However, when encountering contaminants with different viscosities, the scraper 36 can overcome the elastic force of the first spring 351 and slide along the guide rod 352, so that the scraper 36 fits more closely to the inner wall of the centrifugal chamber 7, increasing the contact area with the contaminants, thereby increasing the scraping force on the contaminants. The piezoelectric ceramic 353 is installed at the bottom in the compression direction of the first spring 351. When the first spring 351 is compressed, the pressure of the piezoelectric ceramic 353 changes, causing it to generate a piezoelectric effect to generate current. The current passes through the electrode 354 fixed to the piezoelectric ceramic 353. The electrode 354 is connected to the control system of the centrifugal device through an electrical signal, so that the control system controls the water pump 331 according to the current generated by the piezoelectric ceramic 353, thereby controlling the flow rate of the cleaning liquid.

[0044] As Figure 9 shown in the figure, the first spring 351 includes a variable pitch spiral section 3511 and a variable diameter spiral section 3512. The variable pitch spiral section 3511 is fixedly connected to the scraper 36. The variable pitch spiral section 3511 is fixedly connected to the variable diameter spiral section 3512. The variable diameter spiral section 3512 is fixedly connected to the fixed rod 34.

[0045] The first spring 351 is provided with two sections, namely a variable pitch helical section 3511 and a variable diameter helical section 3512. During low-speed rotary cleaning, the variable pitch helical section 3511 and the scraper 36 are fixed, enabling the scraper 36 to adapt to materials with different viscosities. When cleaning high-viscosity contaminants, a greater contact force is provided, and when cleaning low-viscosity contaminants, a smaller contact force is provided, avoiding incomplete cleaning or excessive wear on the inner wall of the centrifugal chamber 7. Through the variable diameter helical section 3512, a greater elastic support force is provided to limit the displacement of the scraper 36 during high-speed rotation and avoid damage to the adjustment structure caused by excessive centrifugal force.

[0046] As Figure 10 shown, the drainage mechanism 6 includes a drain pipe 61, an electromagnetic coil 62, a return spring 63, and a sliding piece 64. The drain pipe 61 is fixedly connected to the centrifugal chamber 7. The drain pipe 61 is provided with a liquid passage 611. The electromagnetic coil 62 is fixedly connected to the liquid passage 611. The return spring 63 is fixedly connected to the liquid passage 611. The sliding piece 64 is slidably connected to the liquid passage 611, and the sliding piece 64 is fixedly connected to the return spring 63.

[0047] By installing the electromagnetic coil 62 in the drain pipe 61, a magnetic force is generated in the electromagnetic coil 62 passage. Since the sliding piece 64 is made of metal, the sliding piece 64 overcomes the elastic force of the return spring 63, and the sliding piece 64 slides along the liquid passage 611 towards the electromagnetic coil 62, connecting the drain pipe 61 to the external pipe, thereby draining the centrifugal chamber 7. When the centrifugal device is working, the electromagnetic coil 62 is powered off, and the return spring 63 releases its elastic force, causing the sliding piece 64 to slide upward to close the drain pipe 61 and prevent air leakage.

[0048] As Figure 2 and Figure 11 shown, the vacuum mechanism 5 includes a vacuum pump 51, a second housing 52, a second spring 53, and a sealing cover 54. The vacuum pump 51 is connected to the centrifugal chamber 7 through a pipe. The second housing 52 is connected to the vacuum pump 51 through a pipe. The second spring 53 is fixedly connected to the second housing 52. The sealing cover 54 is fixedly connected to the second spring 53, and the sealing cover 54 abuts against the second housing 52.

[0049] By connecting the vacuum pump 51 to the internal pipe of the centrifugal chamber 7, the vacuum pump 51 can extract the gas inside the centrifugal chamber 7. By connecting the gas output end of the vacuum pump 51 to the internal pipe of the second housing 52, the gas is discharged through the second housing 52. By providing the second spring 53 and the sealing cover 54 at the outlet of the second housing 52, when gas needs to be discharged, the second spring 53 is stretched by force, causing the sealing cover 54 to slide upward, thereby connecting the second housing 52 to the outside. When the vacuum pump 51 stops operating, the second spring 53 pulls the sealing cover 54 to seal the outlet of the second housing 52 and prevent air leakage.

[0050] As Figure 12As shown in the figure, the cooling mechanism 4 includes a cooling module 41, an air outlet pipe 42 and an air return pipe 43. The cooling module 41 is fixedly connected to the first housing 1, the air outlet pipe 42 is fixedly connected to the cooling module 41, the air return pipe 43 is fixedly connected to the cooling module 41, the air outlet pipe 42 communicates with the centrifugal chamber 7, and the air return pipe 43 communicates with the centrifugal chamber 7.

[0051] A small amount of cooling gas is input into the centrifugal chamber 7 through the air outlet pipe 42 by the cooling module 41, so as to cool the inside of the centrifugal chamber 7, prevent the heat generated during the high-speed rotation of the rotor 24 from causing the vaccine sample to denature or inactivate. The gas inside the centrifugal chamber 7 is extracted through the air return pipe 43, cooled in the cooling module 41, and then re-input into the centrifugal chamber 7 through the air outlet pipe 42, so as to continuously cool the inside of the centrifugal chamber 7.

[0052] Working principle: The operator puts the tube containing the vaccine on the rotor 24 in the centrifugal chamber 7. The gas inside the centrifugal chamber 7 can be extracted through the vacuum pump 51. The rotating shaft 22 is driven to rotate by the motor 21, driving the rotor 24 installed on the base 23 to rotate at an ultra-high speed. The counterweight slider 312 slides along the annular groove 242, so that the counterweight slider 312 pushes the transmission rod 313 to rotate along the hinge, making the cleaning structure retract into the rotor 24. At the same time, the cooling module 41 inputs a small amount of cooling gas into the centrifugal chamber 7 through the air outlet pipe 42, so as to cool the inside of the centrifugal chamber 7, and cooperate with the air return pipe 43 to circulate the gas inside the centrifugal chamber 7, so as to continuously cool the inside of the centrifugal chamber 7, so as to centrifuge the tube containing the vaccine on the rotor 24. After the separation is completed, the counterweight slider 312 resets under the action of the annular spring 311, and the transmission rod 313 resets under the action of the torsion spring. The vaccine sample is taken out. The rotor 24 is driven to rotate at a low speed by the motor 21 driving the rotating shaft 22. The inner wall of the centrifugal chamber 7 is sprayed with cleaning liquid by the spraying unit 33, so that the scraper 36 and the brush 37 clean the inner wall of the centrifugal chamber 7. At the same time, according to the pollutants with different viscosities, the scraper 36 can overcome the elastic force of the first spring 351 and slide along the guide rod 352, so that the scraper 36 fits more closely to the inner wall of the centrifugal chamber 7, thereby increasing the scraping force on the pollutants. Through the piezoelectric ceramic 353 at the bottom, different currents are generated according to the compression force of the first spring 351. The current is transmitted to the control system through the electrode 354, so that the control system controls the water pump 331 according to the current generated by the piezoelectric ceramic 353, so as to control the flow rate of the cleaning liquid, and discharge the sewage generated by cleaning through the drain pipe 61.

[0053] Finally, it should be noted that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions recorded in the foregoing embodiments or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An ultracentrifugation device for vaccine production with an internal cleaning function, characterized in that: The centrifugal device includes a first housing (1), a centrifugal rotation mechanism (2), an adaptive cleaning mechanism (3), a cooling mechanism (4), a vacuum mechanism (5), a drainage mechanism (6), and a centrifugal chamber (7). The first housing (1) is fixedly connected to the centrifugal chamber (7). The centrifugal rotation mechanism (2) is fixedly connected to the centrifugal chamber (7). The adaptive cleaning mechanism (3) is fixedly connected to the centrifugal rotation mechanism (2). The cooling mechanism (4) is fixedly connected to the centrifugal chamber (7). The vacuum mechanism (5) is connected to the centrifugal chamber (7) through a pipeline. The drainage mechanism (6) is fixedly connected to the centrifugal chamber (7).

2. The ultracentrifugation device for vaccine production with an internal cleaning function according to claim 1, characterized in that: The centrifugal rotation mechanism (2) includes a motor (21), a rotating shaft (22), a base (23), and a rotor (24). The motor (21) is fixedly connected to the centrifugal chamber (7). The output end of the motor (21) is fixedly connected to the rotating shaft (22). The rotating shaft (22) is fixedly connected to the base (23). The rotor (24) is tightly connected to the base (23).

3. The ultra - centrifugation device for vaccine production with internal cleaning function according to claim 2, characterized in that: The adaptive cleaning mechanism (3) includes a centrifugal contraction unit (31), a connecting rod (32), a spraying unit (33), a fixing rod (34), an adjusting mechanism (35), a scraper (36), and a brush (37). The rotor (24) is provided with a movable groove (241). The centrifugal contraction unit (31) is placed in the movable groove (241). The connecting rod (32) is fixedly connected to the centrifugal contraction unit (31). The spraying unit (33) is fixedly connected to the connecting rod (32). The fixing rod (34) is fixedly connected to the connecting rod (32). The adjusting mechanism (35) is fixedly connected to the fixing rod (34). The scraper (36) is slidably connected to the adjusting mechanism (35). The brush (37) is rotatably connected to the fixing rod (34).

4. The ultracentrifugation device for vaccine production with an internal cleaning function according to claim 3, characterized in that: The centrifugal contraction unit (31) includes an annular spring (311), a weight slider (312), and a transmission rod (313). The rotor (24) is provided with an annular groove (242). The annular spring (311) is placed in the annular groove (242). The weight slider (312) is fixedly connected to the annular spring (311). The transmission rod (313) is fixedly connected to the weight slider (312). The transmission rod (313) is fixedly connected to the connecting rod (32). The transmission rod (313) is hinged to the rotor (24). The weight slider (312) is slidably connected to the annular groove (242).

5. The ultracentrifugation device for vaccine production with an internal cleaning function according to claim 4, wherein: The spraying unit (33) includes a water pump (331), a rotary joint (332), a cleaning liquid water tank (333), and a spraying pipe (334). The water pump (331) is connected to the rotary joint (332) through a pipeline. The cleaning liquid water tank (333) is connected to the water pump (331) through a pipeline. The spraying pipe (334) is connected to the rotary joint (332) through a pipeline. The spraying pipe (334) is fixedly connected to the connecting rod (32).

6. The ultracentrifugation device for vaccine production with internal cleaning function according to claim 5, wherein: The adjusting mechanism (35) includes a first spring (351), a guide rod (352), a piezoelectric ceramic (353), and an electrode (354). The first spring (351) is sleeved outside the guide rod (352). The guide rod (352) is fixedly connected to the fixed rod (34). The guide rod (352) is slidably connected to the scraper (36). The piezoelectric ceramic (353) is fixedly connected to the fixed rod (34). The first spring (351) abuts against the piezoelectric ceramic (353). The electrode (354) is fixedly connected to the piezoelectric ceramic (353).

7. The ultracentrifugation device for vaccine production with an internal cleaning function according to claim 6, characterized in that: The first spring (351) includes a variable pitch helical section (3511) and a variable diameter helical section (3512). The variable pitch helical section (3511) is fixedly connected to the scraper (36). The variable pitch helical section (3511) is fixedly connected to the variable diameter helical section (3512). The variable diameter helical section (3512) is fixedly connected to the fixed rod (34).

8. The ultracentrifugation device for vaccine production with an internal cleaning function according to claim 7, characterized in that: The drainage mechanism (6) includes a drain pipe (61), an electromagnetic coil (62), a return spring (63), and a sliding piece (64). The drain pipe (61) is fixedly connected to the centrifugal chamber (7). The drain pipe (61) is provided with a liquid passage (611). The electromagnetic coil (62) is fixedly connected to the liquid passage (611). The return spring (63) is fixedly connected to the liquid passage (611). The sliding piece (64) is slidably connected to the liquid passage (611). The sliding piece (64) is fixedly connected to the return spring (63).

9. The ultracentrifugation device for vaccine production with an internal cleaning function according to claim 8, characterized in that: The vacuum mechanism (5) includes a vacuum pump (51), a second housing (52), a second spring (53), and a sealing cover (54). The vacuum pump (51) is connected to the centrifugal chamber (7) through a pipeline. The second housing (52) is connected to the vacuum pump (51) through a pipeline. The second spring (53) is fixedly connected to the second housing (52). The sealing cover (54) is fixedly connected to the second spring (53). The sealing cover (54) abuts against the second housing (52).

10. The ultracentrifugation device for vaccine production with an internal cleaning function according to claim 9, characterized in that: The cooling mechanism (4) includes a cooling module (41), an air outlet pipe (42), and an air return pipe (43). The cooling module (41) is fixedly connected to the first housing (1). The air outlet pipe (42) is fixedly connected to the cooling module (41). The air return pipe (43) is fixedly connected to the cooling module (41). The air outlet pipe (42) communicates with the centrifugal chamber (7). The air return pipe (43) communicates with the centrifugal chamber (7).

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