Variable-stroke slider-crank mechanism and nucleic acid extraction device

Abstract

The invention relates to a stroke-variable slider-crank mechanism and a nucleic acid extraction device.The stroke-variable slider-crank mechanism comprises a rack, an oscillation sliding rail and an adapter bracket are installed on the rack, a driving motor is installed on the adapter bracket, a rotating crank is connected to an output shaft of the driving motor, and the rotating crank is connected to a rotating shaft of the driving motor; the rotating crank is connected with an oscillation sliding block through a rotating assembly, the oscillation sliding block is installed on the oscillation sliding rail in a sliding fit mode, and the top of the oscillation sliding block is connected with an oscillation component. The rotating crank is connected with a switching guide rod, the switching guide rod is telescopically inserted into the rotating assembly, the insertion length of the switching guide rod relative to the rotating assembly is adjustable, and the switching guide rod is used for adjusting the center distance between the output shaft and the rotating center of the rotating assembly. Magnetic bar sleeve oscillation can be carried out through the crank sliding block rotation mechanism, and meanwhile the amplitude can be adjusted by changing the center distance between the output shaft and the rotation center of the rotation assembly.

Description

Technical Field

[0001] This application relates to the technical field of nucleic acid extraction, and more particularly, to a crank-slider mechanism with variable stroke and a nucleic acid extraction device. Background Art

[0002] In a nucleic acid extraction instrument using the magnetic bead method, the vibration frequency of the magnetic rod sleeve has a great influence on the comprehensive performance of the instrument. Through vibration, the magnetic rod sleeve can fully mix and suspend the sample and the reagent. This can ensure the effective binding of the target nucleic acid to the magnetic beads and improve the efficiency of nucleic acid extraction; the vibration of the magnetic rod sleeve can help the magnetic beads better adsorb the target nucleic acid in the sample solution and fix it on the magnetic rod through the action of the magnetic field. Subsequently, impurities are removed through the washing step to achieve the separation and purification of nucleic acids.

[0003] In current nucleic acid extraction instruments on the market, the reciprocating motion of the magnetic rod sleeve is generally achieved by a motor driving a synchronous belt or a lead screw mechanism. The motor rotates to drive the synchronous belt to move in one direction. After reaching the limit position, the motor rotates in reverse to drive the synchronous belt to move in the other direction, and so on; or the motor drives the lead screw to rotate to make the nut move in one direction. After reaching the limit position, the motor rotates in reverse to drive the lead screw to move in the other direction, and so on.

[0004] To ensure a relatively high frequency, when the motor rotates in reverse, it generally does not decelerate and directly reverses at the maximum speed, which has a greater impact on the service life of the motor, a greater impact on the transmission mechanism, reduces the service life, and the noise will also be very large. Due to the reverse impact, the oscillation frequency cannot be increased significantly, resulting in a reduced experimental effect and an extended experimental time. Moreover, the higher the load mass, the greater the impact, and the oscillation frequency must be significantly reduced, reducing the experimental efficiency. Summary of the Invention

[0005] The purpose of this application is to provide a crank-slider mechanism with variable stroke and a nucleic acid extraction device, which can perform magnetic rod sleeve oscillation through a crank-slider rotary mechanism and can adjust the amplitude by changing the stroke of the crank.

[0006] To achieve the above purpose, in a first aspect, the present invention provides a crank-slider mechanism with variable stroke, including: a frame, on which an oscillation slide rail and a transfer bracket are installed; a driving motor is installed on the transfer bracket, a rotating crank is connected to the output shaft of the driving motor, the rotating crank is connected to an oscillation slider through a rotary assembly, the oscillation slider is slidably installed on the oscillation slide rail, and an oscillation component is connected to the top of the oscillation slider; The rotating crank is connected to a transfer guide rod, the transfer guide rod is telescopically inserted into the rotary assembly, and the insertion length relative to the rotary assembly is adjustable, for being able to adjust the center distance between the output shaft and the rotary center of the rotary assembly.

[0007] In an alternative embodiment, the slewing assembly includes a slewing block and a slewing crank connected to the oscillating slider. The root of the slewing crank is connected to the slewing block through a rotating shaft, and the transfer guide rod is movably inserted on the slewing block.

[0008] In an alternative embodiment, the axis of the rotating shaft constitutes the rotation center of the slewing assembly, and the transfer guide rod can adjust the insertion length on the slewing block according to the horizontal distance or vertical distance between the driving motor and the rotating crank relative to the slewing assembly.

[0009] In an alternative embodiment, one end of the slewing crank is hinged to the oscillating slider, the rotating shaft is hinged to the other end of the slewing crank, and the rotating shaft is hinged to the slewing block.

[0010] In an alternative embodiment, the slewing crank and the oscillating slider are hinged to each other through a connecting shaft, and shoulders are provided between the slewing crank and the side wall of the oscillating slider.

[0011] In an alternative embodiment, the transfer bracket includes a transfer plate and a mounting plate. The driving motor is fixedly installed on the mounting plate, and an adjustment assembly is fixedly connected to the other side of the mounting plate relative to the driving motor. The transfer plate is fixedly connected to the frame, and an adjustment guide rail is fixedly installed on the transfer plate. The mounting plate is connected with an adjustment slider, and the adjustment slider is slidably engaged with the adjustment guide rail and is arranged on the other side of the transfer plate relative to the adjustment assembly; The adjustment assembly can linearly move under the action of the adjustment guide rail and the adjustment slider, and is used to drive the mounting plate, the driving motor, the rotating crank and the transfer guide rod to perform displacement adjustment relative to the slewing assembly.

[0012] In an alternative embodiment, the adjustment assembly includes an adjustment motor, and an adjustment screw rod is fixedly installed on the transfer plate. The adjustment motor is movably installed on the adjustment screw rod.

[0013] In an alternative embodiment, the transfer guide rod includes an inclined guide rod connected to the rotating crank. The driving motor and the rotating crank can be adjusted in distance relative to the slewing assembly under the drive of the adjustment motor; During the adjustment process, the position of the output shaft in the direction perpendicular to the adjustment guide rail is fixed, and the slewing assembly and the oscillating slider slide in the direction parallel to the oscillating slide rail, thereby changing the center distance between the output shaft and the rotating shaft; The adjustment screw rod and the adjustment guide rail are installed in parallel on the transfer plate.

[0014] In an alternative embodiment, the adjusting lead screw includes a threaded lead screw, and the adjusting motor includes a lead screw motor sleeved on the adjusting lead screw.

[0015] In a second aspect, the present invention provides a nucleic acid extractor, which includes the variable-stroke crank-slider mechanism according to any one of the foregoing embodiments, and the oscillating member includes the oscillating platform of the nucleic acid extractor.

[0016] In the variable-stroke crank-slider mechanism of the present invention, the motor can achieve the reciprocating operation of the magnetic rod sleeve without commutation. The reciprocating oscillation of the oscillating member can be formed through the rotating assembly between the crank and the slider, which enhances the smoothness of the oscillation, increases the limit oscillation frequency, significantly reduces the running noise, and can greatly increase the load mass carried by the oscillating slider, creating conditions for nucleic acid extraction with a large sample volume and meeting the requirements of an automated production line for large sample volumes.

[0017] At the same time, the amplitude can be adjusted by changing the center distance between the output shaft and the rotation center of the rotating assembly, and the real-time adjustment of the amplitude of the slider during the oscillation can be achieved.

[0018] Other features and advantages of the present application will be described in detail in the subsequent specific embodiment section. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present application, and therefore should not be regarded as limiting the scope. For those of ordinary skill in the art, other related drawings can be obtained based on these drawings without creative efforts.

[0020] Figure 1 is a schematic structural diagram of the variable-stroke crank-slider mechanism in the present application; Figure 2 is Figure 1 a schematic structural diagram of the other side; Figure 3 is a schematic structural diagram of the nucleic acid extractor.

[0021] Reference Signs: 1 - Frame; 11 - Oscillating slide rail; 12 - Oscillating slider; 2 - Adapter bracket; 21 - Adapter plate; 22 - Mounting plate; 3 - Driving motor; 31 - Rotating crank; 32 - Adapter guide rod; 32a - Inclined guide rod; 33 - Output shaft; 4 - Rotary block; 41 - Rotary crank; 42 - Rotary shaft; 43 - Connecting shaft; 5 - Adjusting motor; 51 - Adjusting lead screw; 52 - Adjusting guide rail; 53 - Adjusting slider; 6 - Oscillation platform. Specific embodiments

[0022] To make the objectives, technical solutions and advantages of the embodiments of this application clearer, the technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of this application. Obviously, the described embodiments are some, but not all, of the embodiments of this application. Components of the embodiments of this application that are usually described and illustrated in the accompanying drawings here can be arranged and designed in various different configurations.

[0023] In the description of this application, it should be noted that the orientation or positional relationship indicated by terms such as "inside", "outside", etc. is based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the products of this application are habitually placed during use. It is only for the convenience of describing this application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation to this application. In addition, terms such as "first", "second", etc. are only used for differential description and cannot be understood as indicating or implying relative importance.

[0024] In the description of this application, it should also be noted that unless otherwise clearly specified and limited, the terms "set", "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood according to specific situations.

[0025] The variable - stroke crank - slider mechanism in this application can relatively adjust the rotation radius of the rotary component by changing the center distance between the output shaft of the motor and the rotation center of the rotary component, and then change the amplitude of the slider connected to the rotary component, creating conditions for adjusting the amplitude of the reciprocating rotary motion component.

[0026] The variable - stroke crank - slider mechanism in this invention is specifically applied to the oscillation platform of a nucleic acid extractor, but it is not limited to being applied only to nucleic acid extractors. It can be understood that for any mechanism that drives a rotary component to perform a rotary motion through a crank, the rotation radius of the rotary component can be adjusted and changed by the variable - stroke crank - slider mechanism in this application, and then the amplitude of the slider connected to the rotary component can be changed, which will not be elaborated here.

[0027] See Figure 1 and in combination with Figure 2, in the variable-stroke crank-slider mechanism of the present application, the main structure includes a frame 1, an oscillating slide rail 11 and a transfer bracket 2 are installed on the frame 1, and a driving motor 3 is installed on the transfer bracket 2. The driving motor 3 serves as a driving structure, and a rotating crank 31 is connected to the output shaft 33 of the driving motor 3, which can output a driving torque to ensure the operation of the rotating crank 31.

[0028] The rotating crank 31 is connected to the oscillating slider 12 through a rotary assembly. The oscillating slider 12 is slidably installed on the oscillating slide rail 11, and an oscillating component for reciprocating movement is connected to the top of the oscillating slider 12.

[0029] Through the above structure, the main components of the crank-slider mechanism are formed. The driving motor 3 transmits the output torque to the rotating crank 31. The rotating crank 31 drives the rotary assembly to perform a rotary motion. Combining the connection between the rotary assembly and the oscillating slider 12, the rotary assembly can drive the oscillating slider 12 to reciprocate on the oscillating slide rail 11. Furthermore, through the connection between the oscillating slider 12 and the oscillating component, the oscillating slider 12 drives the oscillating component to perform a reciprocating movement.

[0030] In the crank-slider mechanism of the present invention, the reciprocating movement of the oscillating component can be realized under the direct driving of the driving motor 3, reducing the commutation operation of the motor. At the same time, the cooperation of the crank, the rotary assembly and the slider constitutes a reliable transmission chain for the output torque, enhancing the smoothness and reliability of the oscillating operation. At the same time, the oscillating frequency can be changed by adjusting the output speed of the driving motor 3, which is beneficial to increasing the limit oscillating frequency.

[0031] The direct driving of the unidirectional rotation of the driving motor 3 avoids the influence on the service life of the motor during the commutation rotation of the motor, reduces the impact on the transmission mechanism, and the noise generated during the commutation process. Based on the avoidance of the commutation rotation, the limit oscillating frequency of the oscillating operation can be increased, and the operation effect can be improved.

[0032] Based on the reciprocating movement of the above oscillating component, in the present invention, the swing radius of the rotary assembly is adjusted by adjusting the center distance between the output shaft 33 and the rotary center of the rotary assembly, and then the amplitudes of the oscillating slider 12 and the oscillating component are adjusted.

[0033] The rotating crank 31 is connected with a transfer guide rod 32. The transfer guide rod 32 is telescopically inserted on the rotating assembly. On the one hand, the transfer guide rod 32 constitutes a transmission connecting rod between the rotating crank 31 and the rotating assembly, enabling the rotating crank 31 and the rotating assembly to rotate synchronously. On the other hand, it can adjust the insertion length of the transfer guide rod 32 and the rotating assembly through the form of telescopic insertion, and further adjust the center distance between the output shaft 33 and the rotation center of the rotating assembly, so as to realize the adjustment and change of the rotation radius of the rotating assembly, thereby adjusting the amplitude of the oscillating slider 12 driven by the rotating assembly.

[0034] The center distance between the output shaft 33 of the driving motor 3 and the rotation center of the rotating assembly is specifically the height distance between the axis of the output shaft 33 and the rotation center of the rotating assembly in the vertically staggered state. In the present application, the above height distance can be adjusted by adjusting the horizontal position of the driving motor 3 in the state of the passive displacement of the rotating assembly and the oscillating slider 12 relative to the oscillating slide rail 11. At the same time, the above height distance can also be adjusted by other forms. It should be understood that all forms of controlling and adjusting the amplitude of the oscillating slider 12 by adjusting the center distance between the output shaft 33 of the driving motor 3 and the rotation center of the rotating assembly should be within the protection scope of the present application and will not be elaborated here.

[0035] In terms of the specific structural composition and variable stroke angle, the rotating assembly includes a rotating block 4 and a rotating crank 41 connected to the oscillating slider 12. The root of the rotating crank 41 is connected to the rotating block 4 through a rotating shaft 42. The transfer guide rod 32 is movably inserted on the rotating block 4. A sleeve hole for the transfer guide rod 32 to movably insert is provided on the rotating block 4. The transfer guide rod 32 and the sleeve hole are in clearance fit and can form an insertion integral body to ensure the synchronous rotation of the transfer guide rod 32 driving the rotating block 4.

[0036] Through this kind of setting composition, the transfer guide rod 32 can rotate synchronously under the drive of the rotating crank 31. At the same time, combined with the insertion of the transfer guide rod 32 on the rotating block 4, the transfer guide rod 32 can drive the rotating block 4 to rotate. Further, combined with the connection between the root of the rotating crank 41 and the rotating block 4 through the rotating shaft 42, the output torque can be transmitted sequentially through the rotating crank 31, the transfer guide rod 32, the rotating block 4 and the rotating crank 41. Combined with the rotation actions of the rotating block 4 and the rotating crank 41, the rotating crank 41 can drive the oscillating slider 12 to reciprocate along the oscillating slide rail 11.

[0037] Based on the fact that the oscillation slider 12 in the present application reciprocates under the drive of the rotating assembly, the rotating shaft 42 connected between the rotating crank 41 and the rotating block 4 constitutes the rotation center of the rotating assembly, that is, the range of the reciprocating movement of the oscillation slider 12 in the present application, that is, the amplitude, is determined by the axis of the rotating shaft 42. Based on the fact that the position of the axis of the output shaft 33 of the driving motor 3 remains unchanged during the rotation process, and the position of the axis of the rotating shaft 42 during the rotation process is a circumferential rotation based on the axis of the output shaft 33 as the base point, the center distance mentioned above is actually the height distance between the axis of the output shaft 33 of the driving motor 3 and the axis of the rotating shaft 42 in the upper and lower staggered state, and the center distance constitutes the rotation radius of the rotating shaft 42 during the rotation process. Combined with the connection between the rotating crank 41 and the rotating shaft 42, the swing amplitude of the rotating crank 41 is adjusted by adjusting the above-mentioned center distance, and finally the technical purpose of adjusting the amplitude of the rotating reciprocating motion component and the oscillation slider 12 by adjusting the rotation radius of the rotating assembly is achieved.

[0038] According to the adjustment form of the center distance mentioned above, in the specific adjustment process, the transfer guide rod 32 can follow the driving motor 3 and the horizontal distance of the rotating crank 31 relative to the rotating assembly to adjust the insertion length on the rotating block 4, thereby meeting the requirement of adjusting the height spacing of the center distance mentioned above by adjusting the horizontal position of the driving motor 3.

[0039] From the connection perspective, one end of the rotary crank 41 is hingedly connected to the oscillation slider 12, and the rotary shaft 42 is hingedly connected to the other end of the rotary crank 41, that is, the root end of the rotary crank 41, and one end of the rotary shaft 42 is hingedly connected to the root end of the rotary crank 41, and the other end of the rotary shaft 42 is hingedly connected to the rotary block 4, so that normal movement needs are met through the form of hinged connection.

[0040] At the same time, in view of the action relationship in which the rotary crank 41 drives the oscillation slider 12 to move back and forth along the oscillation slide rail 11, the rotary crank 41 and the oscillation slider 12 are hingedly connected via a connecting shaft 43. At the same time, in order to improve transmission efficiency, an axial shoulder is provided between the rotary crank 41 and the side wall of the oscillation slider 12 to ensure the high efficiency and reliability of the torque transmission chain, while enabling the rotary crank 41 to maintain effective rotation at the connection portion with the oscillation slider 12.

[0041] In order to achieve automatic control of the oscillation amplitude, the adapter bracket 2 includes an adapter plate 21 and a mounting plate 22. The drive motor 3 is fixedly mounted on the mounting plate 22. An adjustment component is fixedly connected to the mounting plate 22 on the other side of the drive motor 3. The adjustment component can drive the mounting plate 22 to move linearly. Specifically, the adjustment component can include other actuators such as a motor, an electric push rod or a cylinder, which can drive the mounting plate 22 to move linearly during its operation.

[0042] Specifically, the adjustment component in this application is preferably an adjustment motor 5. The adjustment motor 5 can drive the mounting plate 22 and the drive motor 3 to move, and thus the automatic adjustment of the amplitude can be realized by the operation of the adjustment motor 5.

[0043] The adapter plate 21 is fixedly connected to the frame 1, and an adjustment lead screw 51 and an adjustment guide rail 52 are fixedly installed on the adapter plate 21. The adjustment lead screw 51 and the adjustment guide rail 52 are mainly used in cooperation with the adjustment motor 5. The mounting plate 22 is connected with an adjustment slider 53, and the adjustment slider 53 is slidably matched with the adjustment guide rail 52 to complete the linear movement and guiding of the adjustment motor 5, so that the adjustment motor 5 can linearly move under the action of the adjustment guide rail and the adjustment slider.

[0044] To avoid the mutual influence between the linear movement and the guiding of the adjustment motor 5, the adjustment slider 53 and the adjustment guide rail 52 are arranged on the other side of the adapter plate 21 relative to the adjustment lead screw 51.

[0045] The adjustment motor 5 is movably installed on the adjustment lead screw 51 and can linearly move along the lead screw under the reliable guiding action during the operation of the adjustment motor 5, so as to enable the adjustment motor 5 to drive the mounting plate 22, the drive motor 3, the rotating crank 31 and the adapter guide rod 32 to perform displacement adjustment relative to the rotating assembly.

[0046] The adjustment of the center distance in this application includes the specific form of adjusting the horizontal distance between the drive motor 3 and the rotating assembly. Refer to Figure 1 and in combination with Figure 2 , the adapter guide rod 32 is an inclined guide rod 32a connected to the rotating crank 31. The drive motor 3 and the rotating crank 31 can be driven by the adjustment motor 5 to adjust the horizontal distance relative to the rotating assembly. During the adjustment process, the position of the output shaft 33 in the direction perpendicular to the adjustment guide rail 52 is fixed. More specifically, the heights of the drive motor 3 and the output shaft 33 are fixed. The rotating assembly and the oscillating slider 12 passively slide in the direction parallel to the oscillating slide rail 11 relative to the oscillating slide rail 11. More specifically, the rotating assembly and the oscillating slider 12 slide vertically, thereby changing the center distance between the output shaft 33 and the rotating shaft 42.

[0047] In this setting form, the adjustment lead screw 51 and the adjustment guide rail 52 are horizontally and parallelly installed on the adapter plate 21, which can ensure reliable displacement adjustment of the adjustment motor 5.

[0048] It should be noted that the oscillation direction of the oscillating slider 12 is not limited to the vertical direction, and oscillation operations can be performed in the horizontal direction or at any other angle. During the adjustment process, it is necessary to maintain the directional relationship between the drive motor 3, the output shaft 33, the slewing assembly, and the oscillating slider 12 relative to the adjustment guide rail 52 and the oscillating slide rail 11.

[0049] From the perspective of automatic adjustment, in the structural part regarding the adjustment displacement, the adjustment lead screw 51 includes a threaded lead screw, and the adjustment motor 5 includes a lead screw motor sleeved on the adjustment lead screw 51. By operating the lead screw motor, the nut inside it can be driven to rotate. Combining the threaded fit between the nut and the adjustment lead screw 51 can ensure that the adjustment motor 5 moves linearly along the adjustment lead screw 51 during operation, thereby achieving adjustment changes in the horizontal position and the height position.

[0050] The variable-stroke crank-slider mechanism in the present invention can achieve automatic adjustment of the amplitude of the oscillating component compared with the existing structure. At the same time, in the application of the nucleic acid extractor, the amplitude and oscillation frequency can be adjusted according to different reagent volumes and different reagent functions, improving the extraction effect to the greatest extent.

[0051] See Figure 3 , the present invention also provides a nucleic acid extractor, including the variable-stroke crank-slider mechanism described above. The oscillating component includes the oscillating platform 6 of the nucleic acid extractor, which can drive the slider to perform smooth reciprocating oscillations by the crank without the need for the motor to reverse, improving the limit oscillation frequency, avoiding the noise generated when the motor reverses, and can greatly increase the mass of the load carried by the oscillating slider 12, making it possible to extract nucleic acids from a large sample volume and meeting the requirements of an automated production line for a large sample volume.

[0052] It should be pointed out that in addition to adopting the form of the transfer guide rod 32, the form of a transfer guide rail can also be adopted to meet the requirement of adjusting the limit telescopic position of the rotating crank 31 relative to the rotating block 4.

[0053] It should be noted that, without conflict, the features in the embodiments of the present application can be combined with each other.

[0054] The above are only the preferred embodiments of the present application and are not intended to limit the present application. For those skilled in the art, various changes and modifications can be made to the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included within the protection scope of the present application.

Claims

1. A crank-slider mechanism with variable stroke, characterized in that, Comprising: A frame, on which an oscillating slide rail and a transfer bracket are installed. A driving motor is installed on the transfer bracket. A rotating crank is connected to the output shaft of the driving motor. The rotating crank is connected to an oscillating slider through a rotating assembly. The oscillating slider is slidably installed on the oscillating slide rail, and an oscillating component is connected to the top of the oscillating slider. The rotating crank is connected to a transfer guide rod. The transfer guide rod is telescopically inserted on the rotating assembly, and the insertion length relative to the rotating assembly is adjustable, for being able to adjust the center distance between the output shaft and the rotation center of the rotating assembly.

2. The variable-stroke crank-slider mechanism according to claim 1, characterized in that, The rotating assembly includes a rotating block and a rotating rocker connected to the oscillating slider. The root of the rotating rocker is connected to the rotating block through a rotating shaft. The transfer guide rod is movably inserted on the rotating block.

3. The variable-stroke crank-slider mechanism according to claim 2, characterized in that The axis of the rotating shaft constitutes the rotation center of the rotating assembly. The transfer guide rod can adjust the insertion length on the rotating block according to the horizontal distance or vertical distance between the driving motor and the rotating crank relative to the rotating assembly.

4. The variable-stroke crank-slider mechanism according to claim 2, wherein One end of the rotating rocker is hinged to the oscillating slider. The rotating shaft is hinged to the other end of the rotating rocker, and the rotating shaft is hinged to the rotating block.

5. The variable-stroke crank-slider mechanism according to claim 2, wherein The rotating rocker and the oscillating slider are hinged through a connecting shaft, and a shoulder is provided between the side wall of the rotating rocker and the oscillating slider.

6. The variable-stroke crank-slider mechanism according to claim 2, wherein The transfer bracket includes a transfer plate and a mounting plate. The driving motor is fixedly installed on the mounting plate. An adjustment component is fixedly connected to the other side of the mounting plate relative to the driving motor. The transfer plate is fixedly connected to the frame, and an adjustment guide rail is fixedly installed on the transfer plate. The mounting plate is connected with an adjustment slider. The adjustment slider is slidably matched with the adjustment guide rail and is arranged on the other side of the transfer plate relative to the adjustment component. The adjustment component can linearly move under the action of the adjustment guide rail and the adjustment slider, for being able to drive the mounting plate, the driving motor, the rotating crank and the transfer guide rod to perform displacement adjustment relative to the rotating assembly.

7. The crank-slider mechanism with variable stroke according to claim 6, wherein The adjustment component includes an adjustment motor. An adjustment screw rod is fixedly installed on the transfer plate. The adjustment motor is movably installed on the adjustment screw rod.

8. The variable-stroke crank-slider mechanism according to claim 7, wherein, The transfer guide rod includes an inclined guide rod connected to the rotating crank. The driving motor and the rotating crank can be adjusted in distance relative to the rotating assembly under the drive of the adjustment motor. During the adjustment process, the position of the output shaft in the direction perpendicular to the adjustment guide rail is fixed. The rotating assembly and the oscillating slider slide in the direction parallel to the oscillating slide rail, thereby changing the center distance between the output shaft and the rotating shaft. The adjustment screw rod and the adjustment guide rail are installed in parallel on the transfer plate.

9. The crank-slider mechanism with variable stroke according to claim 7, characterized in that, The adjustment screw rod includes a threaded screw rod, and the adjustment motor includes a screw rod motor sleeved on the adjustment screw rod.

10. A nucleic acid extractor, characterized in that, Comprising the variable-stroke crank-slider mechanism according to any one of claims 1-9, characterized in that the oscillating member comprises the oscillating platform of the nucleic acid extractor.

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