Constant-temperature and constant-humidity test box for multi-environment simulation

Abstract

The invention relates to the field of medicine patch production, in particular to a multi-environment simulation constant-temperature and constant-humidity test box. The multi-environment simulation constant-temperature and constant-humidity test box provided by the invention can simulate and test the tension resistance of the medicine patch in different environments, and can conveniently test various performance indexes of the medicine patch in different temperature and humidity environments. A multi-environment simulation constant-temperature and constant-humidity test box comprises a base, a control box, a test box body and the like, the control box is arranged on the upper side of the right portion of the base, and the test box body is arranged on the upper left portion of the base. The pulling hook is connected with the pulling equipment, the pulling equipment applies pulling force step by step, the pulling force acts on the moving plate, the medicine patch is adhered between the moving plate and the penetration detection block, and the pulling force resistance of the medicine patch in different environments can be simulated and tested in cooperation with adjustable environmental parameters in the test box; meanwhile, the performance stability, the adhesive force and the drug effect release characteristic of the medicine patch in different temperature and humidity environments can be conveniently tested.

Description

Technical Field

[0001] The present invention relates to the field of medical patch production, and particularly to a constant temperature and humidity test chamber for multi-environment simulation. Background Art

[0002] A constant temperature and humidity test chamber is a laboratory device used to simulate various environmental conditions, mainly for testing the performance and stability of materials, products or components under different combinations of temperature and humidity.

[0003] The constant temperature and humidity test chamber used in the production process of medical patches is a precision environmental simulation device, which is used to simulate various climatic conditions to test and evaluate the performance stability of medical patches under different temperature and humidity environments, such as adhesion, drug release characteristics, etc. This test chamber plays an important role in the research and development, quality control and storage stability testing of medical patches, ensuring that the medical patches can meet the expected performance and safety standards in actual use. However, the existing constant temperature and humidity test chambers can only simply simulate different temperature and humidity environments, and the actual operation is just to place the finished medical patches, or the medical patches in simulated use, in the chamber and wait statically, then take them out after the detection is completed, and then use the tensile performance test equipment, or the instruments for detecting the drug release characteristics to conduct subsequent performance evaluation operations. During the process of sampling and replacing the test tools, there are certain differences between the external environment and the test environment in the test chamber. Especially, the existing tensile test equipment is completely exposed to the external air, which seriously affects the accuracy of the data and the reliability of the test results during the test detection.

[0004] Therefore, there is an urgent need for a constant temperature and humidity test chamber for multi-environment simulation that can simulate the tensile ability of medical patches in different environments and facilitate the testing of various performance indicators of medical patches under different temperature and humidity environments. Summary of the Invention

[0005] In order to overcome the shortcomings of the prior art in the above background art, the present invention provides a constant temperature and humidity test chamber for multi-environment simulation that can simulate the tensile ability of medical patches in different environments and facilitate the testing of various performance indicators of medical patches under different temperature and humidity environments.

[0006] The technical solution of the present invention is: a constant temperature and humidity test chamber for multi-environment simulation, including a base, a control box, a test chamber, an observation door, an isolation cover, a first motor, a telescopic frame, a swing seat, a penetration detection block, a moving plate and a pressing block. The control box is provided on the upper side of the right part of the base, the test chamber is provided on the upper left part of the base, the observation door is rotatably connected to the left front of the test chamber, the isolation cover is connected to the bottom of the test chamber, the first motor is connected to the isolation cover, a plurality of telescopic frames are connected to the output shaft of the first motor, the swing seat is connected to the telescopic end of the telescopic frame, the penetration detection block is clamped on the swing seat, the moving plate is slidably connected to the top of the swing seat, and the pressing blocks are clamped on the moving plate.

[0007] Further explanation: An observation window is provided in the middle of the observation door.

[0008] Further explanation: The pressing block is of a grid structure and is used to leave a contact space between the medical patch and the internal environment of the test chamber when fixing the medical patch.

[0009] Further explanation: It further includes a support frame and a placement tray. Support frames are connected to the inner sides of the left and right parts of the test chamber, and placement trays are placed on both the upper and lower parts of the support frames.

[0010] Further explanation: It further includes a hook. A plurality of hooks are provided on the top of the moving plate.

[0011] Further explanation: It further includes a second motor, an adjusting lever, a contact frame, a first torsion spring, a locking member, a second torsion spring and a spring. A second motor is provided on the right part of the isolation cover. An adjusting lever is connected to the output shaft of the second motor. Contact frames are rotatably connected to the swinging seats. The contact frames are in extrusion fit with the adjusting lever. A plurality of first torsion springs are connected between the contact frames and the swinging seats. Locking members are rotatably connected to the swinging seats. The locking members are in extrusion fit with the contact frames. A plurality of second torsion springs are connected between the locking members and the swinging seats. A spring is connected between the swinging seats and the telescopic frame.

[0012] Further explanation: It further includes a fixing block and a trigger frame. A fixing block is connected to one side of the moving plate close to the locking member. A trigger frame is provided on the upper part of the locking member. The fixing block is in extrusion fit with the trigger frame.

[0013] Further explanation: It further includes a limiting member. A plurality of limiting members are connected to the swinging seats, and the limiting members are used to limit the extreme positions of the movement of the moving plate.

[0014] Further explanation: It further includes a first telescopic cylinder, a connecting pipe, a second telescopic cylinder and an arc-shaped airbag. A first telescopic cylinder is provided on one side of the swinging seat away from the contact frame. A second telescopic cylinder is arranged below the locking member. The second telescopic cylinder is connected to the swinging seat. A connecting pipe is connected between the first telescopic cylinder and the second telescopic cylinder. An arc-shaped airbag is provided at the output end of the second telescopic cylinder, and the arc-shaped airbag is in extrusion fit with the bottom of the locking member.

[0015] The beneficial effects of the present invention are as follows: 1. In the present invention, the pulling device is connected through a hook, and the pulling device applies a pulling force step by step. The pulling force acts on the moving plate, and the medical patch is adhered between the moving plate and the penetration detection block. With the adjustable environmental parameters in the test chamber, it can simulate the tensile resistance of the medical patch in different environments, and at the same time facilitate the test of the performance stability, adhesion and drug efficacy release characteristics of the medical patch under different temperature and humidity environments.

[0016] 2. In the present invention, the rotation of the output shaft of the first motor drives the rotation of the telescopic frame, and the rotation of the telescopic frame drives the overall movement of the swing seat. When the swing seat moves, the contact frame will move to contact the adjustment lever. At this time, the contact frame is squeezed by the adjustment lever to pull the swing seat to move. When the swing seat moves, the telescopic end of the telescopic frame extends, and the spring is stretched by the force. Until the contact frame separates from the adjustment lever, the spring automatically rebounds to control the reset of the swing seat, causing the swing seat to generate a reciprocating jitter movement on the telescopic frame. When the swing seat swings reciprocally, the moving plate and the pressing block will generate a certain impact force under the influence of gravity and inertia force. This impact inertia can be utilized to test the adhesion performance of the medical patch in an active state under different environments. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic three-dimensional structure diagram of the present invention in the closed state.

[0018] Figure 2 It is a schematic three-dimensional structure diagram of the present invention in the open state.

[0019] Figure 3 It is a schematic structure diagram of components such as the isolation cover, the first motor, and the telescopic frame of the present invention.

[0020] Figure 4 It is a schematic three-dimensional structure diagram of components such as the telescopic frame, the swing seat, and the penetration detection block of the present invention.

[0021] Figure 5 It is an exploded three-dimensional view of components such as the moving plate, the hook, and the pressing block of the present invention.

[0022] Figure 6 It is a schematic structure diagram of components such as the swing seat, the penetration detection block, the moving plate, and the hook of the present invention.

[0023] Figure 7 It is a schematic three-dimensional structure diagram of components such as the second motor, the adjustment lever, and the contact frame of the present invention.

[0024] Figure 8 It is a schematic three-dimensional structure diagram of components such as the adjustment lever, the contact frame, and the locking member of the present invention.

[0025] Figure 9 It is a schematic three-dimensional structure diagram of components such as the first torsion spring, the locking member, and the second torsion spring of the present invention.

[0026] Figure 10 It is a schematic structure diagram of components such as the limiting member, the first telescopic cylinder, and the connecting pipe of the present invention.

[0027] Figure 11 It is a schematic three-dimensional structure diagram of components such as the connecting pipe, the second telescopic cylinder, and the arc-shaped airbag of the present invention.

[0028] In the above drawings: 1: base, 2: control box, 3: test chamber, 4: observation door, 5: support frame, 6: placement tray, 7: isolation cover, 8: first motor, 9: telescopic frame, 10: swing seat, 11: penetrant testing block, 12: moving plate, 1201: hook, 13: pressing block, 14: second motor, 15: adjusting lever, 16: contact frame, 17: first torsion spring, 18: locking member, 19: second torsion spring, 20: spring, 21: fixed block, 22: trigger frame, 23: limiting member, 24: first telescopic cylinder, 25: connecting pipe, 26: second telescopic cylinder, 27: arc-shaped airbag. Detailed implementation manners

[0029] The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which the currently preferred embodiments of the invention are shown. However, the invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided for thoroughness and completeness and fully convey the scope of the invention to those skilled in the art.

[0030] A thermostatic and humidistatic test chamber for multi-environment simulation, as Figures 1 - 11As shown, it includes a base 1, a control box 2, a test box 3, an observation door 4, a support frame 5, a placement plate 6, an isolation cover 7, a first motor 8, a telescopic frame 9, a swing seat 10, a penetration detection block 11, a moving plate 12, a hook 1201, a pressure block 13, a second motor 14, an adjustment lever 15, a contact frame 16, a first torsion spring 17, a locking member 18, a second torsion spring 19, a spring 20, a fixing block 21, a trigger frame 22, a limiting member 23, a first telescopic cylinder 24, a connecting pipe 25, a second telescopic cylinder 26 and an arc-shaped airbag 27. The control box 2 is provided on the upper right side of the base 1, and the base 1 is provided on the upper left side. The test box 3 has an observation door 4 rotatably connected to the left front portion of the test box 3, support frames 5 are connected to the inner sides of the left and right parts of the test box 3, and a placement plate 6 is placed on the upper and lower parts of the support frames 5. An isolation cover 7 is connected to the bottom of the test box 3, and a first motor 8 is connected to the isolation cover 7. A plurality of telescopic frames 9 are connected to the output shaft of the first motor 8, and a swing seat 10 is connected to the telescopic end of the telescopic frame 9. A penetration detection block 11 is clamped on the swing seat 10, and a moving plate 12 is slidably connected to the top of the swing seat 10. A plurality of hooks 1201 are provided on the top of the moving plate 12, and a pressing block 13 is clamped on the moving plate 12. The right side of the isolation cover 7 The part is provided with a second motor 14, and an adjusting lever 15 is connected to the output shaft of the second motor 14. The second motor 14 controls the adjusting lever 15 to rotate, and the toggle range can be adjusted. The swing seat 10 is rotatably connected with a contact frame 16, and the contact frame 16 is pressed and matched with the adjusting lever 15. A plurality of first torsion springs 17 are connected between the contact frame 16 and the swing seat 10. A locking piece 18 is rotatably connected to the swing seat 10, and the locking piece 18 is pressed and matched with the contact frame 16. A plurality of second torsion springs 19 are connected between the locking piece 18 and the swing seat 10. A spring 20 is connected between the swing seat 10 and the telescopic frame 9, and the moving plate A fixing block 21 is connected to the side of 12 close to the locking member 18, a trigger frame 22 is provided on the upper part of the locking member 18, the fixing block 21 is squeezed and matched with the trigger frame 22, a plurality of limit members 23 are connected to the swing seat 10, the limit members 23 are used to limit the extreme position of the movement of the movable plate 12, a first telescopic cylinder 24 is provided on the side of the swing seat 10 away from the contact frame 16, a second telescopic cylinder 26 is connected to the swing seat 10, a connecting pipe 25 is connected between the first telescopic cylinder 24 and the second telescopic cylinder 26, an arc-shaped airbag 27 is provided on the output end of the second telescopic cylinder 26, and the arc-shaped airbag 27 is squeezed and matched with the bottom of the locking member 18.

[0031] When the present invention is in use, after the tester opens the observation door 4, the pressing block 13 is removed from the moving plate 12, and then the penetration detection block 11 is placed on the swing seat 10. After that, the test patch sample is pasted onto the surface of the penetration detection block 11, with the ointment part in contact with the penetration detection block 11 and the excess part pasted on the surface of the moving plate 12. Then, the pressing block 13 is snap-connected to the moving plate 12 to press and fix the patch, so that the patch is tightly adhered to the moving plate 12. After that, the observation door 4 can be closed. Through the control box 2, the temperature and humidity parameters inside the test chamber 3 are adjusted to the parameters required for the test. By changing the temperature and humidity parameters, different test environments can be simulated. During the test process, the state of the patch can be observed through the observation door 4. After the test is completed, the penetration detection block 11 is taken out, and the amount of medicine penetration into the penetration detection block 11 is detected, so as to be able to detect the medicine release ability of the patch in different temperature and humidity environments. At the same time, the tensile property of the patch can also be detected using different test environments. The ultimate test of the tensile property is carried out by connecting a pulling device through the hook 1201. The specific working principle is as follows: Before the test, the pulling device is placed inside the test chamber 3, and the part of the pulling device that outputs the pulling force is connected to the hook 1201. Then, the start time of the pulling device is set, and the start time is adapted to the time required for the purpose of the constant temperature and humidity test of the patch. After that, the patch sample can be set, and after completion, the test is carried out. When this time point is reached, the pulling device applies a pulling force to the moving plate 12 through the hook 1201, and the patch is adhered between the moving plate 12 and the penetration detection block 11. There is a pressing block 13 on the moving plate 12 to increase the adhesion firmness of the patch, and the penetration detection block 11 is directly adhered to the patch. The tightness of the adhesion between the patch and the penetration detection block 11 depends on the adhesion and tensile resistance performance of the patch itself. When the tensile resistance performance of the patch is strong in a specific environment, it is difficult to separate the patch from the penetration detection block 11, so the pulling force value that the pulling device needs to apply is high. If the tensile resistance performance of the patch is weak in a specific environment, the patch can be easily separated from the penetration detection block 11, so the pulling force value that the pulling device needs to apply is low. The tensile resistance performance of the patch can be intuitively tested in different environments. And the pressing block 13 can press the patch tightly. When the back surface and the adhesive surface of the patch are delaminated, it will still be in an integral state, avoiding errors in the test data of the tensile resistance performance of the patch caused by patch delamination and improving the accuracy of the test data. When simulating the adhesion performance of the patch in different temperature and humidity environments, the first motor 8 is started. The output shaft of the first motor 8 rotates to drive the telescopic frame 9 to rotate. The rotation of the telescopic frame 9 drives the overall movement of the swing seat 10. When the swing seat 10 moves, the contact frame 16 will move to contact the adjusting lever 15. At this time, the contact frame 16 is pulled by the adjusting lever 15 to move the swing seat 10. When the swing seat 10 moves, the telescopic end of the telescopic frame 9 extends, and the spring 20 is stretched by force. Until the contact frame 16 separates from the adjusting lever 15, the spring 20 automatically rebounds to control the swing seat 10 to reset, causing the swing seat 10 to generate a reciprocating jitter movement on the telescopic frame 9.Due to the influence of gravity and inertia force, the reciprocating swing of the swing seat 10 causes the moving plate 12 and the pressing block 13 to generate a certain impact force. By utilizing this impact inertia, the adhesion performance of the medical patch in an active state under different environments is tested. When the medical patch detaches from the penetration detection block 11 during the reciprocating swing, the moving plate 12 will slide under the action of inertia. When the moving plate 12 slides towards the contact frame 16, the fixed block 21 first contacts the trigger frame 22. The trigger frame 22 is squeezed to control the rotation of the locking member 18. When the locking member 18 rotates, it loses contact with the contact frame 16, enabling the first torsion spring 17 to rebound. The rebound of the first torsion spring 17 controls the contact frame 16 to rotate clockwise by 90 degrees. After the medical patch detaches and the swing seat 10 moves to the position of the adjusting lever 15 again, the adjusting lever 15 will no longer contact the contact frame 16 on the swing seat 10. When the swing seat 10 of the remaining non-detached medical patch passes through the adjusting lever 15, the contact frame 16 contacts the adjusting lever 15 normally. When the swing seat 10 slides towards the first telescopic cylinder 24 when the medical patch detaches, after contacting and squeezing the first telescopic cylinder 24, the gas inside the first telescopic cylinder 24 is transported to the second telescopic cylinder 26 through the connecting pipe 25. The second telescopic cylinder 26 transports the gas to the arc-shaped airbag 27, causing the arc-shaped airbag 27 to expand and push open the locking member 18, repeating the working principle after the separation of the locking member 18 and the contact frame 16. After the test is completed, record the test results, take out the test items, and clean and disinfect the inside of the test box 3.

[0032] As described above, it is only the specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention can easily think of changes or substitutions, which should all be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claimed rights.

Claims

1. A thermostatic and humidistatic test chamber for multi - environment simulation, characterized in that, It includes a base (1), a control box (2), a test box (3), an observation door (4), an isolation cover (7), a first motor (8), a telescopic frame (9), a swing seat (10), a penetrant testing block (11), a moving plate (12) and a pressing block (13). On the upper side of the right part of the base (1), there is a control box (2). On the upper left part of the base (1), there is a test box (3). On the left side of the front part of the test box (3), there is an observation door (4) rotatably connected. At the inner bottom of the test box (3), there is an isolation cover (7) connected. On the isolation cover (7), there is a first motor (8) connected. On the output shaft of the first motor (8), there are multiple telescopic frames (9) connected. On the telescopic end of the telescopic frame (9), there is a swing seat (10) connected. On the swing seat (10), there is a penetrant testing block (11) snap-connected. On the top of the swing seat (10), there is a moving plate (12) slidably connected. On the moving plate (12), there are pressing blocks (13) snap-connected.

2. The thermostatic and humidistatic test chamber for multi-environment simulation according to claim 1, characterized in that, In the middle of the observation door (4), there is an observation window.

3. A thermostatic and humidistatic test chamber for multi-environment simulation according to claim 1, characterized in that, The pressing block (13) is of a grid structure and is used to retain the contact space between the medical patch and the internal environment of the test box (3) when fixing the medical patch.

4. A temperature and humidity test chamber for multi-environment simulation according to claim 3, characterized in that, It also includes a support frame (5) and a placement tray (6). On the inner sides of the left and right parts of the test box (3), there are support frames (5) connected. On the upper and lower parts of the support frame (5), there are placement trays (6) placed.

5. A temperature and humidity test chamber for multi-environment simulation according to claim 4, characterized in that, It also includes a hook (1201). On the top of the moving plate (12), there are multiple hooks (1201).

6. A thermostatic and humidistatic test chamber for multi-environment simulation according to claim 5, characterized in that, It also includes a second motor (14), an adjusting lever (15), a contact frame (16), a first torsion spring (17), a locking part (18), a second torsion spring (19) and a spring (20). On the right part of the isolation cover (7), there is a second motor (14) connected. On the output shaft of the second motor (14), there is an adjusting lever (15) connected. On the swing seat (10), there are contact frames (16) rotatably connected. The contact frame (16) is in extrusion fit with the adjusting lever (15). Between the contact frame (16) and the swing seat (10), there are multiple first torsion springs (17) connected. On the swing seat (10), there are locking parts (18) rotatably connected. The locking part (18) is in extrusion fit with the contact frame (16). Between the locking part (18) and the swing seat (10), there are multiple second torsion springs (19) connected. Between the swing seat (10) and the telescopic frame (9), there is a spring (20) connected.

7. A thermostatic and humidistatic test chamber for multi-environment simulation according to claim 6, characterized in that, It also includes a fixing block (21) and a trigger frame (22). On the side of the moving plate (12) close to the locking part (18), there is a fixing block (21) connected. On the upper part of the locking part (18), there is a trigger frame (22). The fixing block (21) is in extrusion fit with the trigger frame (22).

8. A thermostatic and humidistatic test chamber for multi-environment simulation according to claim 7, characterized in that, It also includes a limiting part (23). On the swing seat (10), there are multiple limiting parts (23) connected. The limiting part (23) is used to limit the extreme position of the movement of the moving plate (12).

9. A thermostatic and humidistatic test chamber for multi-environment simulation according to claim 8, characterized in that, It further includes a first telescopic cylinder (24), a connecting pipe (25), a second telescopic cylinder (26) and an arc-shaped airbag (27). A first telescopic cylinder (24) is provided on one side of the swing seat (10) away from the contact frame (16). A second telescopic cylinder (26) is arranged below the locking member (18). The second telescopic cylinder (26) is connected to the swing seat (10). A connecting pipe (25) is connected between the first telescopic cylinder (24) and the second telescopic cylinder (26). An arc-shaped airbag (27) is provided at the output end of the second telescopic cylinder (26). The arc-shaped airbag (27) is in extrusion fit with the bottom of the locking member (18).

Images