Blood glucose real-time detection and early warning device in hemodialysis

Abstract

The blood glucose real-time detection and early warning device comprises a connector, a shell base and a dynamic glucometer, one end of the connector is fixedly connected to a dialysis arterial duct, the open end of the shell base is inserted into the connector, and a flow guide plate is transversely arranged in the shell base and close to the open end; a dynamic glucometer installation cavity is formed in the side, away from the open end, of the shell base, and the dynamic glucometer is installed in the dynamic glucometer installation cavity. According to the blood glucose real-time detection early warning device in hemodialysis, the connector is matched with the shell base, the dynamic blood glucose meter is installed on the shell base, real-time detection of blood glucose in blood flowing through a dialysis arterial duct is achieved, detected data can be connected with a controller and a displayer of a dialysis machine, the blood glucose data are displayed in real time, and the blood glucose real-time detection early warning device is convenient to use. And an alarm of the dialysis machine can be used for early warning.

Description

Technical Field

[0001] The present invention relates to a device for detecting blood glucose during hemodialysis, and particularly to a device for real-time detection and warning of blood glucose during hemodialysis. Background Art

[0002] With the development of society, there are more and more patients with chronic kidney diseases who need hemodialysis to maintain life. Most dialysis centers in China currently use sugar-free dialysate for dialysis. Symptomatic or asymptomatic hypoglycemia that occurs during dialysis is a common acute complication. In severe cases, it can lead to complications such as the death of patients. Therefore, during dialysis, medical staff need to closely monitor the blood glucose level of patients.

[0003] Currently, there are two common blood sampling methods for detecting the blood glucose level of patients during dialysis:

[0004] The first is an invasive detection method, the fingertip blood sampling method: After disinfecting the blood sampling site at the fingertip of the patient's ring finger with alcohol and waiting for it to dry, use a blood sampling needle to puncture, discard the first drop of blood, drop the second drop of blood on the test strip, wait to read the data and then record it, and press the blood sampling site with a cotton swab. This invasive detection method requires puncturing the fingertip of the patient's ring finger, which will increase the pain of the patient and also increase the psychological pressure on the patient.

[0005] The second is a non-invasive detection method. After the start of hemodialysis, the nurse performs a blood glucose test on the patient, using the on-line blood sampling method at the arterial end of the extracorporeal circulation blood circuit: First, stop ultrafiltration, then slow down the blood flow rate to 100 mL / min. After 15 - 30 s, disinfect the blood sampling point at the arterial end of the extracorporeal circulation blood circuit with alcohol and wait for it to dry. Use a 1 mL syringe to draw 0.1 mL of blood specimen and drop it on the test strip, wait to read the data and then record it. The second non-invasive detection method has the advantages of convenient blood sampling, non-invasive, not increasing the pain of the patient, reducing the risks of infection, bleeding, etc. caused by conventional fingertip blood sampling at the distal end. Therefore, most patients choose the second non-invasive detection method.

[0006] The above detection methods have the following deficiencies:

[0007] 1. Both of the above two detection methods collect blood glucose data at regular intervals. If we want to continuously obtain the changes in the patient's blood glucose during dialysis, we need to continuously puncture the fingertip of the patient's ring finger or continuously puncture the arterial end of the extracorporeal circulation blood circuit for on-line blood sampling. Repeatedly puncturing the fingertip of the patient's ring finger will increase the pain of the patient even more. Repeatedly puncturing the arterial end of the extracorporeal circulation blood circuit will also generate debris, and once the debris enters the human body, it can cause blood vessel thrombosis.

[0008] 2. Both of the above two detection methods rely entirely on medical staff to complete, which is both time-consuming and unable to achieve continuous real-time collection, and unable to monitor the blood glucose fluctuation in real time.

[0009] 3. The blood collection needle, syringe, and test strip used in the above process are all disposable. The more times of collection, the more consumables and the higher the cost. SUMMARY OF THE INVENTION

[0010] In view of the deficiencies in the above-mentioned prior art, the present invention provides a real-time blood glucose detection and warning device for hemodialysis.

[0011] To solve the above technical problems, the present invention adopts the following technical solutions:

[0012] The real-time blood glucose detection and warning device for hemodialysis includes a connector arranged on the dialysis arterial tube, a housing base connected to the connector, and a dynamic blood glucose meter installed on the housing base for detecting blood glucose in the arterial tube; one end of the connector is fixedly connected to the dialysis arterial tube, one end of the housing base is open, and the open end of the housing base is inserted into the connector from the other end of the connector and is hermetically connected to the inner wall of the connector; a diversion plate is horizontally arranged in the housing base near the open end, the diversion plate is perpendicular to the axis of the dialysis arterial tube, and the diversion plate gradually thickens from the inner side near the housing base to the outer side of the open end; a dynamic blood glucose meter installation cavity is arranged on one side of the housing base away from the open end, the dynamic blood glucose meter is installed in the dynamic blood glucose meter installation cavity, the sensor of the dynamic blood glucose meter is located at the bottom of the dynamic blood glucose meter installation cavity, the soft needle electrode of the dynamic blood glucose meter passes through the housing base at the bottom of the dynamic blood glucose meter installation cavity and extends into the inner cavity of the housing base, and the signal transmitter of the dynamic blood glucose meter is close to the outside of the dynamic blood glucose meter installation cavity.

[0013] As a preferred solution of the present invention, the dynamic blood glucose meter is fixedly installed in a box body with one end open, the box body is inserted into the dynamic blood glucose meter installation cavity, the open end of the box body is located outside the dynamic blood glucose meter installation cavity, through holes Ⅰ are arranged at the bottom of the box body and the housing base at the bottom of the dynamic blood glucose meter installation cavity, and the soft needle electrode of the dynamic blood glucose meter passes through the through hole Ⅰ.

[0014] As a preferred solution of the present invention, a puncture hole is further arranged on one side of the housing base away from the open end, and a sealing rubber plug is arranged in the puncture hole.

[0015] As a preferred solution of the present invention, the diversion plate divides the open end of the housing base into a liquid inlet and a liquid outlet, and a filter membrane is arranged between the inner wall of the housing base and the diversion plate near the liquid outlet.

[0016] As a preferred solution of the present invention, the puncture hole is located on the left side of the dynamic blood glucose meter installation cavity. After the box body is inserted into the dynamic blood glucose meter installation cavity, the box body is fixed in the dynamic blood glucose meter installation cavity through a buckle mechanism, and the bottom of the box body is hermetically matched with the bottom of the dynamic blood glucose meter installation cavity.

[0017] As a preferred embodiment of the present invention, the buckle mechanism includes a spring I, a locking tongue, a positioning sleeve I, a push rod, a spring II and a positioning sleeve II; guiding holes I are provided on the front and rear walls of the box body, and through guiding holes II are provided at the front and rear positions of the housing base and located in the dynamic blood glucose meter installation cavity; the two guiding holes I on the box body and the two guiding holes II on the housing base correspond to each other in the front-rear direction; a spring I, a locking tongue and a positioning sleeve I are arranged in each guiding hole I, the positioning sleeve I is fixedly arranged in the guiding hole I and close to the hole opening, the locking tongue passes through the positioning sleeve I and is in sliding fit with the inner wall of the positioning sleeve I, one end of the locking tongue is located inside the positioning sleeve I, the other end of the locking tongue is inserted into the corresponding guiding hole II, one end of the spring I presses on the inner side wall of the guiding hole I, and the other end of the spring I presses on the locking tongue; a push rod, a spring II and a positioning sleeve II are arranged in each guiding hole II, the guiding hole II is successively composed of a guiding hole section I, a guiding hole section II and a guiding hole section III, the guiding hole section I is close to the dynamic blood glucose meter installation cavity, the guiding hole section III is close to the outer side wall of the housing base, the inner hole diameter of the guiding hole section III is larger than that of the guiding hole section II, and the inner hole diameter of the guiding hole section II is larger than that of the guiding hole section I; the push rod is inserted into the guiding hole II, one end of the push rod is located in the guiding hole section I, the other end of the push rod is located outside the housing base, guiding protrusions I and II are arranged on the outer wall of the push rod, the guiding protrusion I is located in the guiding hole section II and is in sliding fit with the inner wall of the guiding hole section II, the positioning sleeve II is fixedly arranged in the guiding hole section III and close to the hole opening, the push rod passes through the positioning sleeve II and is in sliding fit with the inner wall of the positioning sleeve II, the guiding protrusion II is located in the guiding hole section III and is in sliding fit with the inner wall of the guiding hole section III, the guiding protrusion II is located inside the positioning sleeve II, the spring II is sleeved on the push rod, one end of the spring II presses on the annular protrusion formed between the guiding hole section I and the guiding hole section II, and the other end of the spring II presses on the guiding protrusion II.

[0018] As a preferred embodiment of the present invention, the blood glucose real-time detection and warning device during hemodialysis further includes a pressing sleeve. The puncture hole is successively composed of a puncture hole section I, a puncture hole section II and a puncture hole section III from bottom to top. The inner hole diameter of the puncture hole section III is larger than that of the puncture hole section II, and the inner hole diameter of the puncture hole section II is larger than that of the puncture hole section I. The sealing rubber plug is installed in the puncture hole section II. The pressing sleeve is inserted into the puncture hole section III and presses on the top of the sealing rubber plug. The bottom of the sealing rubber plug presses on the circular protrusion formed between the puncture hole section I and the puncture hole section II near the outer circle.

[0019] As a preferred embodiment of the present invention, an L-shaped guiding groove composed of an axial guiding groove arranged along its axial direction and a radial guiding groove arranged along its radial direction is provided on the inner wall of the puncture hole section III. A guiding block is provided on the outer wall of the pressing sleeve and near the bottom. The guiding block on the pressing sleeve is inserted into the L-shaped guiding groove and rotated into the radial guiding groove.

[0020] As a preferred embodiment of the present invention, an L-shaped guiding clamping groove composed of an axial clamping groove arranged along its axial direction and a radial clamping groove arranged along its radial direction is provided on the inner wall of the joint. A guiding block is provided on the outer wall of the housing base and near the open end. The guiding block on the housing base is inserted into the L-shaped guiding clamping groove and rotated into the radial clamping groove. A sealing groove is arranged along the circumferential direction at the bottom of the radial clamping groove on the inner wall of the joint. A sealing ring is arranged in the sealing groove. The housing base is hermetically connected to the joint through the sealing ring.

[0021] As a preferred embodiment of the present invention, the blood glucose real-time detection and warning device in hemodialysis further includes an operation pad arranged on the dialysis arterial tube. The operation pad and the joint are located on the same cross-section of the dialysis arterial tube and on the two axial sides of the dialysis arterial tube.

[0022] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0023] 1. The blood glucose real-time detection and warning device in hemodialysis cooperates with the joint and the housing base to install the dynamic blood glucose meter on the housing base, realizing real-time detection of the blood glucose in the blood flowing through the dialysis arterial tube, with more accurate detection. The detected data can be connected to the controller and display of the dialysis machine to display the blood glucose data in real time, detect the blood glucose fluctuation in real time, and give a warning through the alarm of the dialysis machine.

[0024] 2. The blood glucose real-time detection and warning device in hemodialysis can realize real-time detection of blood glucose changes during hemodialysis. Compared with the existing blood sampling detection, it not only avoids the infection risk brought by the existing puncture blood sampling for blood glucose detection, but also reduces the manual operation of medical staff and the measurement data deviation.

[0025] 3. The blood glucose real-time detection and warning device in hemodialysis not only is provided with a dynamic blood glucose meter, but also has a puncture hole on the housing base. A sealing rubber plug is arranged in the puncture hole. If blood sampling or drug injection is needed, only the puncture needle of the syringe needs to pierce the sealing rubber plug to perform blood sampling and drug injection. To avoid debris generated when the puncture needle pierces the sealing rubber plug from entering the patient's body, a filter membrane is arranged between the inner wall of the housing base and the diversion plate and near the liquid outlet.

[0026] 4. The real-time blood sugar detection and early warning device during hemodialysis can closely monitor the patient's blood sugar level during dialysis, detect hypoglycemia early and take timely intervention measures to prevent other complications caused by severe hypoglycemia to the patient, thereby ensuring the safety of the patient's dialysis. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a structural schematic diagram of a real-time blood sugar detection and early warning device in hemodialysis;

[0028] Figure 2 It is a schematic diagram of the three-dimensional structure of the joint;

[0029] Figure 3 It is a schematic diagram of the structure of the connector cut along its guide groove;

[0030] Figure 4 It is a schematic diagram of the structure in which the sealing ring is installed in the sealing groove on the joint;

[0031] Figure 5 It is a schematic diagram of the three-dimensional structure of the shell base;

[0032] Figure 6 is a schematic diagram of the cross-sectional structure of the shell base;

[0033] Figure 7 It is a schematic diagram of the three-dimensional structure of the box;

[0034] Figure 8 It is a schematic diagram of the structure in which the box body and the sealing rubber plug are installed in the housing base;

[0035] Figure 9 It is a structural schematic diagram of a dynamic blood glucose meter and a sealing rubber plug installed in a housing base;

[0036] Figure 10 yes Figure 8 Schematic diagram of the cross-section structure along the AA direction;

[0037] Figure 11 yes Figure 10 The enlarged structural diagram at B in the middle;

[0038] Figure 12 yes Figure 10 The enlarged structural diagram of the part B in the middle without the buckle mechanism;

[0039] Figure 13 It is a schematic diagram of the structure of the push rod;

[0040] Figure 14 It is a structural schematic diagram of a compression sleeve.

[0041] In the figure: 1 - dialysis arterial tube; 2 - connector; 21 - guiding card slot; 22 - sealing slot; 3 - housing base; 31 - dynamic blood glucose meter installation cavity; 32 - puncture hole; 321 - puncture hole section I; 322 - puncture hole section II; 323 - puncture hole section III; 3231 - guiding slot; 33 - guiding hole II; 331 - guiding hole section I; 332 - guiding hole section II; 333 - guiding hole section III; 4 - dynamic blood glucose meter; 41 - sensor; 42 - soft needle electrode; 43 - signal transmitter; 5 - flow guiding plate; 6 - box body; 61 - through hole I; 62 - guiding hole I; 63 - boss I; 7 - sealing rubber plug; 8 - filter membrane; 9 - buckle mechanism; 91 - spring I; 92 - locking tongue; 93 - positioning sleeve I; 94 - push rod; 941 - guiding convex block I; 942 - guiding convex block II; 943 - operating handle; 95 - spring II; 96 - positioning sleeve II; 10 - pressing sleeve; 101 - guiding block; 102 - annular boss II; 11 - sealing ring; 12 - operating pad. Detailed implementation mode

[0042] The present invention will be described in detail below in conjunction with embodiments and drawings.

[0043] As Figure 1 shown, a real-time blood glucose detection and warning device during hemodialysis includes a connector 2 provided on a dialysis arterial tube 1, a housing base 3 connected to the connector 2, a dynamic blood glucose meter 4 installed on the housing base 3 for detecting blood glucose in the arterial tube 1, a flow guiding plate 5, a box body 6, a sealing rubber plug 7, a filter membrane 8, and a pressing sleeve 10. The dynamic blood glucose meter 4 is a prior art, which mainly includes a sensor 41 and a signal transmitter 43, and a soft needle electrode 42 is provided on the sensor 41. The signal transmitter 43 can be connected to the controller of the hemodialysis machine or to the mobile phone of medical staff. After receiving the signal from the sensor 41, the signal transmitter 43 transmits it to the hemodialysis machine, and the blood glucose situation of the patient can be displayed at any time through the display of the hemodialysis machine. If the blood glucose of the patient exceeds the preset highest value or is lower than the preset lowest value, real-time warning will be given.

[0044] Among them, the bottom end of the connector 2 is fixedly connected to the dialysis arterial tube 1. The structure of the connector 2 is as Figure 2 shown. A guiding card slot 21 with an L-shaped structure composed of an axial card slot arranged along its axis and a radial card slot arranged along its radius is provided on the inner wall of the connector 2. In this embodiment, two L-shaped guiding card slots 21 are provided on the inner wall of the connector 2, and the radial card slots of the two guiding card slots 21 are arranged in the same clockwise or the same counterclockwise direction along the circumference. A sealing slot 22 is arranged along the circumferential direction at the bottom of the radial card slot on the inner wall of the connector 2. As Figure 3 shown, a sealing ring 11 is arranged in the sealing slot 22. As Figure 4As shown, the housing base 3 is sealingly connected to the joint 2 through a sealing ring 11. In this embodiment, on the inner wall of the joint 2 and at the bottom of the sealing groove 22, there is an annular support platform with an inner hole diameter smaller than the upper inner hole diameter. After the sealing ring 11 is snapped into the sealing groove 22, this annular support platform can better support the sealing ring 11.

[0045] The structure of the housing base 3 is as Figure 5 and Figure 6 shown. One end of the housing base 3 is open, that is, a cavity with an open bottom is formed inside the housing base 3. Guide blocks 34 are provided on the outer wall of the housing base 3 and near the open end. In this embodiment, two guide blocks 34 corresponding to two guide slots 21 on the inner wall of the joint 2 are provided on the outer wall of the housing base 3 and near the open end. The open end of the housing base 3 is inserted into the joint 2 from the top of the joint. The guide blocks 34 on the housing base 3 move downward along the axial slot of the guide slot 21 and rotate into the radial slot, thereby connecting the housing base 3 to the joint 2. The open end of the housing base 3 presses on the sealing ring 11 and is sealingly connected to the inner wall of the joint 2 through this sealing ring 11. A flow guide plate 5 is horizontally arranged near the open end inside the housing base 3. The flow guide plate 5 is perpendicular to the axis of the dialysis arterial tube 1. The flow guide plate 5 gradually thickens from the inner side near the housing base 3 to the outer side of the open end, that is, the thickness of the flow guide plate 5 gradually becomes thicker from the side away from the axis of the dialysis arterial tube 1 to the side close to the axis of the dialysis arterial tube 1. As Figure 1 shown, all the edges of the flow guide plate 5 are arc-shaped transitions. The flow guide plate 5 divides the open end of the housing base 3 into a liquid inlet and a liquid outlet. When the blood flowing through the dialysis arterial tube 1 passes through the joint 2, under the guiding and splitting action of the flow guide plate 5, the part of the blood near the inner wall of the joint 2 in the dialysis arterial tube 1 enters the cavity of the housing base 3 through the liquid inlet and flows along the flow path formed between the flow guide plate 5 and the inner wall of the cavity of the housing base 3, and finally flows out from the liquid outlet and returns to the dialysis arterial tube 1 again.

[0046] On the housing base 3 and on the side far from the open end, there are a dynamic blood glucose meter installation cavity 31 and a puncture hole 32. The puncture hole 32 is located on the left side of the dynamic blood glucose meter installation cavity 31, as Figure 6 shown.

[0047] The dynamic blood glucose meter 4 is installed in the dynamic blood glucose meter installation cavity 31. The sensor 41 of the dynamic blood glucose meter 4 is located at the bottom of the dynamic blood glucose meter installation cavity 31. The soft needle electrode 42 of the dynamic blood glucose meter 4 passes through the housing base 3 at the bottom of the dynamic blood glucose meter installation cavity 31 and extends into the inner cavity of the housing base 3. The signal transmitter 43 of the dynamic blood glucose meter 4 is close to the outside of the dynamic blood glucose meter installation cavity 31. In this embodiment, the dynamic blood glucose meter 4 is fixedly installed in a box body 6 with an open end. The structure of the box body 6 is as Figure 7As shown, the cartridge 6 is inserted into the dynamic blood glucose meter installation cavity 31, and the open end of the cartridge 6 is located outside the dynamic blood glucose meter installation cavity 31. As Figure 8 shown, through holes I 61 are provided at the bottom of the cartridge 6 and the housing base 3 at the bottom of the dynamic blood glucose meter installation cavity 31, and the soft needle electrode 42 of the dynamic blood glucose meter 4 passes through the through holes I 61. As Figure 9 shown. In order to facilitate the installation or removal of the cartridge 6, a protruding boss I 63 can be provided on the outside of the cartridge 6 near the top. After the cartridge 6 is installed in the dynamic blood glucose meter installation cavity 31, the boss I 63 is located outside the dynamic blood glucose meter installation cavity 31, and it is more convenient to install or remove the cartridge 6 by applying force through the boss I 63. The dynamic blood glucose meter 4 is installed in the cartridge 6 so that its surroundings and bottom (except for the soft needle electrode 42 extending out of the through hole I 61) form a sealed fit with the inner surroundings and bottom of the cartridge 6. After the cartridge 6 is removed, only the outer surface of the cartridge 6 and the soft needle electrode 42 need to be disinfected, and then the dynamic blood glucose meter 4 can be reused. If, after the cartridge 6 is installed in the dynamic blood glucose meter installation cavity 31, the bottom of the cartridge 6 forms a seal with the bottom in the dynamic blood glucose meter installation cavity 31 (except for the soft needle electrode 42 extending out of the through hole I 61), only the outer wall of the housing base 3, the inner wall of the cavity, and the soft needle electrode 42 need to be disinfected, and then the housing base 3 and the dynamic blood glucose meter 4 installed therein can be reused, greatly reducing the usage cost.

[0048] After the cartridge 6 is inserted into the dynamic blood glucose meter installation cavity 31, the cartridge 6 is fixed in the dynamic blood glucose meter installation cavity 31 through a buckle mechanism 9, and the bottom of the cartridge 6 is in sealed cooperation with the bottom of the dynamic blood glucose meter installation cavity 31. Buckle mechanisms 9 are provided at the front and rear of the housing base 3 in the dynamic blood glucose meter installation cavity 31. As Figure 10 shown. The buckle mechanism 9 includes a spring I 91, a locking tongue 92, a positioning sleeve I 93, a push rod 94, a spring II 95, and a positioning sleeve II 96. As Figure 11 shown, guiding holes I 62 are provided on the front and rear walls of the cartridge 6, and through guiding holes II 33 are provided at the front and rear positions of the housing base 3 in the dynamic blood glucose meter installation cavity 31. As Figure 12 shown. The two guiding holes I 62 on the cartridge 6 and the two guiding holes II 33 on the housing base 3 correspond to each other in the front-rear direction. A spring I 91, a locking tongue 92, and a positioning sleeve I 93 are provided in each guiding hole I 62. As Figure 11As shown in the figure, the positioning sleeve I 93 is fixedly arranged in the guiding hole I 62 and near the hole opening. The locking tongue 92 passes through the positioning sleeve I 93 and is in sliding fit with the inner wall of the positioning sleeve I 93. The left end of the locking tongue 92 is located on the left side of the positioning sleeve I 93, and the right end of the locking tongue 92 is inserted into the corresponding guiding hole II 33. A slope is formed near the right end at the bottom of the locking tongue 92, and the edges are all rounded. When the box body 6 starts to be inserted into the dynamic blood glucose meter installation cavity 31, it is beneficial for the locking tongue 92 to slide into the dynamic blood glucose meter installation cavity 31 and retract into the guiding hole I 62. After the box body 6 is completely inserted into the dynamic blood glucose meter installation cavity 31, the locking tongue 92 extends and is inserted into the guiding hole II 33, thereby fixing the box body 6 in the dynamic blood glucose meter installation cavity 31. One end of the spring I 91 presses on the inner side wall of the guiding hole I 62, and the other end of the spring I 91 presses on the locking tongue 92. A push rod 94, a spring II 95 and a positioning sleeve II 96 are arranged in each guiding hole II 33. As Figure 11 shown, the guiding hole II 33 is successively composed of a guiding hole section I 331, a guiding hole section II 332 and a guiding hole section III 333. As Figure 12 shown, the guiding hole section I 331 is close to the dynamic blood glucose meter installation cavity 31, the guiding hole section III 333 is close to the outer side wall of the housing base 3, the inner hole diameter of the guiding hole section III 333 is larger than that of the guiding hole section II 332, and the inner hole diameter of the guiding hole section II 332 is larger than that of the guiding hole section I 331; the push rod 94 is inserted into the guiding hole II 33, one end of the push rod 94 is located in the guiding hole section I 331, and the other end of the push rod 94 is located outside the housing base 3. Guiding bumps I 941 and guiding bumps II 942 are arranged on the outer wall of the push rod 94, and the outer end of the push rod 94 protrudes in the circumferential direction to form an operating handle 943. As Figure 13 shown, the guiding bump I 941 is located in the guiding hole section II 332 and is in sliding fit with the inner wall of the guiding hole section II 332. The positioning sleeve II 96 is fixedly arranged in the guiding hole section III 333 and near the hole opening. The push rod 94 passes through the positioning sleeve II 96 and is in sliding fit with the inner wall of the positioning sleeve II 96. The guiding bump II 942 is located in the guiding hole section III 333 and is in sliding fit with the inner wall of the guiding hole section III 333. The guiding bump II 942 is located inside the positioning sleeve II 96. The spring II 95 is sleeved on the push rod 94. One end of the spring II 95 presses on the annular convex platform formed between the guiding hole section I 331 and the guiding hole section II 332, and the other end of the spring II 95 presses on the guiding bump II 942.

[0049] When installing the cartridge body 6, under the action of the spring II 95, the push rod 94 is on the side away from the dynamic blood glucose meter installation cavity 31. When the cartridge body 6 is just inserted into the dynamic blood glucose meter installation cavity 31, the bottom of the cartridge body 6 contacts the top inner wall of the dynamic blood glucose meter installation cavity 31. Under the extrusion force, the locking tongue 92 retracts into the guiding hole I 62, and the cartridge body 6 slides downward in the dynamic blood glucose meter installation cavity 31. After the cartridge body 6 is completely inserted into the dynamic blood glucose meter installation cavity 31, the locking tongue 92 corresponds to the guiding hole II 33. Under the action of the spring I 91, the locking tongue 92 is driven to insert into the guiding hole II 33 and the cartridge body 6 is fixed in the dynamic blood glucose meter installation cavity 31. When it is necessary to take out the cartridge body 6, press the operation handles 943 on the front and rear sides with fingers to drive the push rod 94 to move inward. The push rod 94 pushes the locking tongue 92 to drive the locking tongue 92 to withdraw from the guiding hole II 33 and retract into the guiding hole I 62. The spring I 91 and the spring II 95 are compressed. At the same time, drive the boss I 63 to move upward with a hand or other tool, so as to drive the cartridge body 6 to move upward until the cartridge body 6 leaves the dynamic blood glucose meter installation cavity 31, and then take out the dynamic blood glucose meter 4.

[0050] The puncture hole 32 is successively composed of a puncture hole section I 321, a puncture hole section II 322 and a puncture hole section III 323 from bottom to top. As Figure 6 shown, the inner hole diameter of the puncture hole section III 323 is larger than that of the puncture hole section II 322, and the inner hole diameter of the puncture hole section II 322 is larger than that of the puncture hole section I 321. The sealing rubber plug 7 is installed in the puncture hole section II 322. On the inner wall of the puncture hole section III 323, a guiding groove 3231 with an L-shaped structure composed of an axial guiding groove arranged along its axial direction and a radial guiding groove arranged along its radial direction is provided. The structure of the pressing sleeve is as Figure 14As shown in the figure, a guide block 101 is provided on the outer wall of the pressing sleeve 10 and near the bottom, and an outward protruding annular boss II 102 is provided on the outer wall of the pressing sleeve 10 and near the top. After the pressing sleeve 10 is installed in the puncture hole section III 323, the annular boss II 102 is located outside the puncture hole section III 323. By applying force through the boss I 63, it is more convenient to install or remove the pressing sleeve 10. In this embodiment, two L-shaped guide grooves 3231 are provided on the inner wall of the puncture hole section III 323, and the radial guide grooves of the two guide grooves 3231 are arranged in the same clockwise or counterclockwise direction along the circumference; two guide blocks 101 corresponding to the two guide grooves 3231 are provided near the bottom of the outer wall of the pressing sleeve 10. The pressing sleeve 10 is inserted into the puncture hole section III 323 from the top of the puncture hole section III 323. The guide blocks 101 on the pressing sleeve 10 move downward along the axial guide groove of the L-shaped guide groove 3231 and rotate into the radial guide groove. The bottom of the pressing sleeve 10 presses on the top of the sealing rubber plug 7, and the bottom of the sealing rubber plug 7 and near the outer circle press on the circular boss formed between the puncture hole section I 321 and the puncture hole section II 322. When installing the sealing rubber plug 7, just place the sealing rubber plug 7 in the puncture hole section II 322, hold the pressing sleeve 10 through the annular boss II 102, align the guide blocks 101 on the pressing sleeve 10 with the guide grooves 3231, press and then rotate a certain angle, and the sealing rubber plug 7 can be tightly installed in the puncture hole 32. After the blood glucose is detected in real time, hold the annular boss II 102 again, rotate the pressing sleeve 10 by a certain angle, and then pull out the pressing sleeve 10 upward, and the sealing rubber plug 7 can be replaced. After disinfecting the pressing sleeve 10 and the housing base 3, the housing base 3 and the pressing sleeve 10 can be reused, greatly reducing the cost.

[0051] If blood sampling or drug injection is required, just pierce the sealing rubber plug 7 with the puncture needle of the syringe, and the blood flowing through the cavity of the housing base 3 can be extracted, that is, the blood flowing through the dialysis arterial tube 1 can be extracted, and drugs can also be injected into the cavity of the housing base 3. After the drug solution is mixed with the blood in the cavity of the housing base 3, they flow into the dialysis arterial tube 1 together and continue to flow forward, and finally enter the patient's body. To prevent debris from entering the patient's body when the puncture needle punctures the sealing rubber plug 7, a filter membrane 8 is provided between the inner wall of the housing base 3 and the diversion plate 5 and near the liquid outlet. The filter membrane 8 can effectively filter out debris.

[0052] The blood glucose real-time detection and warning device for hemodialysis also includes an operation pad 12 provided on the dialysis arterial tube 1. The operation pad 12 and the joint 2 are located on the same cross-section of the dialysis arterial tube 1 and on the axial two sides of the dialysis arterial tube 1. When blood sampling or drug injection is required, just hold the operation pad 12 with one hand to fix the position of the housing base 3, and the other hand can operate the puncture needle of the syringe to pierce the sealing rubber plug 7 to perform blood sampling or drug injection.

[0053] When blood flows through the joint 2 in the dialysis arterial tube 1, the blood near the joint 2, under the guiding and diverting action of the flow guiding plate 5, a part of the blood on the inner wall of the dialysis arterial tube 1 near the joint 2 enters the cavity of the housing base 3 through the liquid inlet, and flows along the flow path formed between the flow guiding plate 5 and the inner wall of the cavity of the housing base 3. When the blood flowing into the cavity of the housing base 3 passes through the soft needle electrode 42, an oxidation reaction occurs between the soft needle electrode 42 and the blood sugar in the blood, and a current proportional to the blood sugar concentration is formed, directly reflecting the level of blood sugar in the patient's body through the level of the electrical signal, and emitting a signal outward through the signal transmitter 43 of the dynamic blood analyzer 4. Through the guidance of the flow guiding plate 5, the flowing direction of the blood flowing into the cavity of the housing base 3 is changed, and the blood flow rate of the blood flowing into the cavity of the housing base 3 is reduced. The volume of the cavity of the housing base 3 is larger than the cross-section intercepted by the flow guiding plate 5 when flowing through the joint 2, so that the blood flow rate of the blood flowing into the cavity of the housing base 3 is further reduced. Coupled with the provided filter membrane 8, the filter membrane 8 can slow down the blood flowing through the cavity of the housing base 3 again, so that the time for the blood to stay in full contact with the soft needle electrode 42 is slightly delayed when the blood flows through the soft needle electrode 42, which is beneficial to the full reaction of the blood sugar flowing through the soft needle electrode 42 with the soft needle electrode 42, making the detected blood sugar more stable and accurate. The filter membrane 8 can not only slow down the blood flow rate in the cavity of the housing base 3, but also filter out the debris generated by the puncture of the puncture needle through the sealing rubber plug 7. After the blood flowing through the cavity of the housing base 3 is filtered by the filter membrane 8, it finally flows out from the liquid outlet and returns to the dialysis arterial tube 1 again.

[0054] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the spirit and scope of the technical solutions of the present invention, and they should all be covered by the scope of the claims of the present invention.

Claims

1. Real-time blood glucose detection and warning device during hemodialysis, characterized in that: It includes a connector (2) provided on a dialysis arterial tube (1), a housing base (3) connected to the connector (2), and a dynamic blood glucose monitor (4) installed on the housing base (3) for detecting blood glucose in the arterial tube (1); One end of the connector (2) is fixedly connected to the dialysis arterial tube (1). One end of the housing base (3) is open. The open end of the housing base (3) is inserted into the connector (2) from the other end of the connector (2) and is hermetically connected to the inner wall of the connector (2). A flow guide plate (5) is horizontally arranged near the open end in the housing base (3). The flow guide plate (5) is perpendicular to the axis of the dialysis arterial tube (1). The flow guide plate (5) gradually thickens from the inner side near the housing base (3) to the outer side of the open end; On the side of the housing base (3) away from the open end, there is a dynamic blood glucose monitor installation cavity (31). The dynamic blood glucose monitor (4) is installed in the dynamic blood glucose monitor installation cavity (31). The sensor (41) of the dynamic blood glucose monitor (4) is located at the bottom of the dynamic blood glucose monitor installation cavity (31). The soft needle electrode (42) of the dynamic blood glucose monitor (4) passes through the housing base (3) at the bottom of the dynamic blood glucose monitor installation cavity (31) and extends into the inner cavity of the housing base (3). The signal transmitter (43) of the dynamic blood glucose monitor (4) is close to the outside of the dynamic blood glucose monitor installation cavity (31).

2. The blood glucose real-time detection and warning device in hemodialysis according to claim 1, characterized in that: The dynamic blood glucose monitor (4) is fixedly installed in a box body (6) with one end open. The box body (6) is inserted into the dynamic blood glucose monitor installation cavity (31). The open end of the box body (6) is located outside the dynamic blood glucose monitor installation cavity (31). Through holes Ⅰ (61) are provided at the bottom of the box body (6) and the housing base (3) at the bottom of the dynamic blood glucose monitor installation cavity (31). The soft needle electrode (42) of the dynamic blood glucose monitor (4) passes through the through hole Ⅰ (61).

3. The blood glucose real-time detection and warning device in hemodialysis according to claim 2, wherein: On the side of the housing base (3) away from the open end, there is also a puncture hole (32). A sealing rubber plug (7) is arranged in the puncture hole (32).

4. The blood glucose real-time detection and warning device in hemodialysis according to claim 3, wherein: The flow guide plate (5) divides the open end of the housing base (3) into a liquid inlet and a liquid outlet. A filter membrane (8) is arranged between the inner wall of the housing base (3) and the flow guide plate (5) and near the liquid outlet.

5. The blood glucose real-time detection and warning device in hemodialysis according to claim 4, characterized in that: The puncture hole (32) is located on the left side of the dynamic blood glucose monitor installation cavity (31). After the box body (6) is inserted into the dynamic blood glucose monitor installation cavity (31), the box body (6) is fixed in the dynamic blood glucose monitor installation cavity (31) through a buckle mechanism (9). The bottom of the box body (6) is hermetically matched with the bottom of the dynamic blood glucose monitor installation cavity (31).

6. The blood glucose real-time detection and warning device in hemodialysis according to claim 5, characterized in that: The snap mechanism (9) includes a first spring (91), a locking tongue (92), a first positioning sleeve (93), a push rod (94), a second spring (95) and a second positioning sleeve (96); guide holes I (62) are provided on the front and rear walls of the box body (6), and through guide holes II (33) are provided at the front and rear positions of the housing base (3) and located in the dynamic blood glucose meter installation cavity (31); the two guide holes I (62) on the box body (6) and the two guide holes II (33) on the housing base (3) are in one-to-one correspondence in the front-rear direction; A first spring (91), a locking tongue (92) and a first positioning sleeve (93) are provided in each of the guide holes I (62). The first positioning sleeve (93) is fixedly arranged in the guide hole I (62) and close to the hole opening. The locking tongue (92) passes through the first positioning sleeve (93) and is in sliding fit with the inner wall of the first positioning sleeve (93). One end of the locking tongue (92) is located inside the first positioning sleeve (93), and the other end of the locking tongue (92) is inserted into the corresponding guide hole II (33). One end of the first spring (91) presses against the inner side wall of the guide hole I (62), and the other end of the first spring (91) presses against the locking tongue (92); A push rod (94), a second spring (95) and a second positioning sleeve (96) are provided in each of the guide holes II (33). The guide hole II (33) is successively composed of a first guide hole section (331), a second guide hole section (332) and a third guide hole section (333). The first guide hole section (331) is close to the dynamic blood glucose meter installation cavity (31), the third guide hole section (333) is close to the outer side wall of the housing base (3), the inner hole diameter of the third guide hole section (333) is larger than the inner hole diameter of the second guide hole section (332), and the inner hole diameter of the second guide hole section (332) is larger than the inner hole diameter of the first guide hole section (331); the push rod (94) is inserted into the guide hole II (33). One end of the push rod (94) is located in the first guide hole section (331), and the other end of the push rod (94) is located outside the housing base (3). Guide protrusions I (941) and II (942) are provided on the outer wall of the push rod (94). The guide protrusion I (941) is located in the second guide hole section (332) and is in sliding fit with the inner wall of the second guide hole section (332). The second positioning sleeve (96) is fixedly arranged in the third guide hole section (333) and close to the hole opening. The push rod (94) passes through the second positioning sleeve (96) and is in sliding fit with the inner wall of the second positioning sleeve (96). The guide protrusion II (942) is located in the third guide hole section (333) and is in sliding fit with the inner wall of the third guide hole section (333). The guide protrusion II (942) is located inside the second positioning sleeve (96). The second spring (95) is sleeved on the push rod (94). One end of the second spring (95) presses against the annular protrusion formed between the first guide hole section (331) and the second guide hole section (332), and the other end of the second spring (95) presses against the guide protrusion II (942).

7. The real-time blood glucose detection and warning device for hemodialysis according to claim 6, wherein: It further includes a compression sleeve (10). The puncture hole (32) is successively composed of a puncture hole section I (321), a puncture hole section II (322), and a puncture hole section III (323) from bottom to top. The inner hole diameter of the puncture hole section III (323) is larger than that of the puncture hole section II (322), and the inner hole diameter of the puncture hole section II (322) is larger than that of the puncture hole section I (321). The sealing rubber plug (7) is installed in the puncture hole section II (322). The compression sleeve (10) is inserted into the puncture hole section III (323) and presses on the top of the sealing rubber plug (7). The bottom of the sealing rubber plug (7) presses on the circular boss formed between the puncture hole section I (321) and the puncture hole section II (322) near the outer circle.

8. The real-time blood glucose detection and warning device for hemodialysis according to claim 7, wherein: A guiding groove (3231) with an L-shaped structure composed of an axial guiding groove arranged along its axis and a radial guiding groove arranged along its radius is provided on the inner wall of the puncture hole section III (323). A guiding block (101) is provided on the outer wall of the compression sleeve (10) near the bottom. The guiding block (101) on the compression sleeve (10) is inserted into the L-shaped guiding groove (3231) and rotates into the radial guiding groove.

9. The blood glucose real-time detection and warning device for hemodialysis according to claim 8, characterized in that: A guiding clamping groove (21) with an L-shaped structure composed of an axial clamping groove arranged along its axis and a radial clamping groove arranged along its radius is provided on the inner wall of the joint (2). A guiding block (34) is provided on the outer wall of the housing base (3) near the open end. The guiding block (34) on the housing base (3) is inserted into the L-shaped guiding clamping groove (21) and rotates into the radial clamping groove. A sealing groove (22) is arranged along the circumferential direction at the bottom of the radial clamping groove on the inner wall of the joint (2). A sealing ring (11) is arranged in the sealing groove (22). The housing base (3) is hermetically connected to the joint (2) through the sealing ring (11).

10. The blood glucose real-time detection and warning device in hemodialysis according to claim 9, characterized in that: It further includes an operation pad (12) arranged on the dialysis arterial tube (1). The operation pad (12) and the joint (2) are located on the same cross-section of the dialysis arterial tube (1) and on the two axial sides of the dialysis arterial tube (1).

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