Traditional Chinese medicine formula for treating psoriasis related to tonsillitis and preparation method
Through the precise configuration and dynamic heating control of medicinal materials such as cicada shells, the lack of targeting problem of the existing Chinese medicine formula for treating tonsillitis-related psoriasis is solved, the full extraction of active ingredients and consistency of the efficacy is achieved, the recurrence rate is significantly reduced, and the controllability and safety of the treatment effect are improved.
Patent Information
- Application Number
- CN202510715537.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-30
- Publication Date
- 2025-07-11
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing formula for traditional Chinese medicine for treating tonsillitis-related psoriasis lacks targeting, strong preparation process, and insufficient extraction of effective ingredients. In particular, there is a lack of effective specific treatment plans for wind-heat damage syndrome, a special syndrome induced by streptococcal infection, which is difficult to achieve stable control of drug efficacy and effective reduction of recurrence rate.
The precise configuration of medicinal materials such as cicada shed, silkworm, cypress, duckweed, madder, verbena, wild yam, hive, white yam, and halter flower lotus is adopted, combined with double decoction extraction and dynamic heating control, and the heating parameters are monitored and iteratively adjusted through temperature sensors to ensure the full extraction and stable release of the active ingredients of the medicinal liquid, and the finished medicinal liquid is further purified through the process of stand-alt precipitation and supernatant aliquoting process.
The standardization and precision of the preparation process of traditional Chinese medicine has been achieved, the consistency of the efficacy and the controllability of the preparation process have been improved, the recurrence rate of tonsillitis-related psoriasis has been significantly reduced, and the persistence and safety of the treatment effect have been improved.
Smart Images
Figure HDA0005428131450000011 
Figure HDA0005428131450000021
Abstract
Description
Technical Field
[0001] This application relates to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine formula for treating psoriasis related to tonsillitis and a preparation method thereof. Background Art
[0002] Psoriasis is a common chronic and recurrent inflammatory skin disease, characterized by epidermal hyperplasia and abnormal activation of the immune system. The clinical manifestations are erythema, scales and itching. The course of the disease is prolonged and recurrent, seriously affecting the quality of life of patients. Among them, guttate psoriasis is closely related to streptococcal infection (such as tonsillitis), with strong inductivity and recurrence.
[0003] According to traditional Chinese medicine theory, psoriasis mostly belongs to syndromes such as "blood heat", "blood dryness" and "blood deficiency". Syndrome differentiation and treatment is the core treatment idea, and traditional Chinese medicine prescriptions such as activating blood circulation and cooling blood, dispelling wind and relieving itching are often used for treatment. However, there are generally problems in the current traditional Chinese medicine treatment of psoriasis, such as lack of targeting in the formula, strong randomness in the preparation process, and insufficient extraction of active ingredients. Especially in the treatment of the special syndrome type of wind-heat injuring collaterals induced by streptococcal infection, there is a lack of effective specific treatment plans, and it is difficult to achieve stable control of drug efficacy and effective reduction of the recurrence rate. Summary of the Invention
[0004] This application provides a traditional Chinese medicine formula for treating psoriasis related to tonsillitis and a preparation method thereof, solves the technical problem that the prior art lacks a traditional Chinese medicine formula for psoriasis related to tonsillitis, and achieves the technical effect of providing a traditional Chinese medicine formula that can effectively eliminate the symptoms of psoriasis related to tonsillitis and reduce the recurrence rate.
[0005] In view of the above problems, on the one hand, this application provides a traditional Chinese medicine formula for treating psoriasis related to tonsillitis, and the traditional Chinese medicine formula is made from the following components and their parts by weight: 8 - 12 parts of cicada slough, 8 - 12 parts of bombyx batryticatus, 12 - 18 parts of lithospermum root, 8 - 12 parts of duckweed, 12 - 18 parts of rubia cordifolia, 12 - 18 parts of verbena officinalis, 12 - 18 parts of glabrous greenbrier rhizome, 8 - 12 parts of nidus vespae, 12 - 18 parts of oldenlandia diffusa, 12 - 18 parts of scutellaria barbata.
[0006] Preferably, the specific parts by weight of the traditional Chinese medicine formula are as follows: 10 parts of cicada slough, 10 parts of bombyx batryticatus, 15 parts of lithospermum root, 10 parts of duckweed, 15 parts of rubia cordifolia, 15 parts of verbena officinalis, 15 parts of glabrous greenbrier rhizome, 10 parts of nidus vespae, 15 parts of oldenlandia diffusa, 15 parts of scutellaria barbata.
[0007] On the other hand, the present application also provides a method for preparing a traditional Chinese medicine composition for treating psoriasis related to tonsillitis. The method includes: configuring medicinal materials according to the first ratio of a preset traditional Chinese medicine formula, and soaking the configured medicinal materials; when the soaking time meets the preset soaking time, pouring the soaked medicinal materials and soaking water into a container, and adding clear water to the container until the first preset water volume constraint is met, obtaining a first container to be heated that is ready; obtaining the basic information of the heater, determining the first heating parameter of the heater in combination with the characteristics of periostracum cicadae, bombyx batryticatus, herba lemnaceae, and nidus vespae in the preset traditional Chinese medicine formula, and determining the second heating parameter of the heater according to the basic information and the characteristics of lithospermum root, rubia cordifolia, verbena officinalis, glabrous greenbrier rhizome, oldenlandia diffusa, and scutellaria barbata in the preset traditional Chinese medicine formula; heating the first container to be heated according to the first heating parameter until it boils, obtaining a first parameter adjustment instruction; adjusting the parameter of the heater to the second heating parameter according to the first parameter adjustment instruction, continuously monitoring the temperature of the first container to be heated, and performing feedback adjustment on the second heating parameter according to the monitoring result until the first preset duration is met, stopping heating, filtering the first container to be heated, obtaining the first filtered medicinal residues and the first collected medicinal liquid; performing secondary decoction on the first filtered medicinal residues to obtain the second collected medicinal liquid; aggregating, standing, and precipitating the first collected medicinal liquid and the second collected medicinal liquid, and taking the supernatant for sub-packaging to obtain the sub-packaged traditional Chinese medicine set that is prepared.
[0008] Preferably, adjusting the parameter of the heater according to the first parameter adjustment instruction includes: continuously monitoring the temperature of the first container to be heated within a preset monitoring window by using a temperature sensor to obtain a sequence of monitored temperature values; iteratively adjusting the second heating parameter according to the sequence of monitored temperature values to obtain a corrected second heating parameter, and adjusting the parameter of the heater according to the corrected second heating parameter.
[0009] Preferably, iteratively adjusting the second heating parameter according to the sequence of monitored temperature values to obtain a corrected second heating parameter includes: traversing the sequence of monitored temperature values to extract the mode and determining the representative monitored temperature value; calculating the fluctuation variance of the sequence of monitored temperature values, and determining the iterative bandwidth according to the calculation result; constructing a first representative neighborhood of the representative monitored temperature value in the sequence of monitored temperature values based on the iterative bandwidth; iteratively expanding the first representative neighborhood according to the iterative bandwidth until the preset iterative expansion stop condition is met to obtain a target representative neighborhood; calculating the mean value of the target representative neighborhood to obtain a target monitored temperature value; and adjusting the second heating parameter according to the target monitored temperature value to obtain the corrected second heating parameter.
[0010] Preferably, the difference between any monitored temperature value within the first representative neighborhood and the representative monitored temperature value is less than or equal to the iteration bandwidth.
[0011] Preferably, iteratively expand the first representative neighborhood according to the iteration bandwidth until a preset iteration expansion stop condition is met to obtain a target representative neighborhood, including: expanding the first representative neighborhood according to the iteration bandwidth to obtain a second representative neighborhood; determining whether the neighborhood density of the second representative neighborhood is greater than or equal to the neighborhood density of the first representative neighborhood, and if so, continue to iteratively expand the second representative neighborhood until a preset iteration expansion stop condition is met to obtain the target representative neighborhood.
[0012] Preferably, when the neighborhood density of the second representative neighborhood is less than the neighborhood density of the first representative neighborhood, the first representative neighborhood is used as the target representative neighborhood.
[0013] Preferably, perform secondary decoction on the first filtered medicinal residues to obtain a second collected medicinal liquid, including: placing the first filtered medicinal residues in a container, adding clear water to the container until a second preset water volume constraint is met to obtain a second container to be heated; heating the second container to be heated according to a first heating parameter using a heater until boiling to obtain a second parameter adjustment instruction; adjusting the parameters of the heater to a second heating parameter according to the second parameter adjustment instruction, continuously heating the second container to be heated for a second preset duration using the heater with adjusted parameters, then stopping heating, and filtering the second container to be heated to obtain the second collected medicinal liquid.
[0014] Preferably, the first preset water volume constraint is that the water volume in the container is 8 times the weight of the medicinal materials before soaking.
[0015] One or more technical solutions provided in this application have at least the following beneficial effects:
[0016] Through the compatibility idea of "expelling wind and promoting eruption, cooling blood and detoxifying", this application provides a traditional Chinese medicine formula for psoriasis of wind-heat injuring collaterals syndrome induced by tonsillitis, which has a fast onset and a low recurrence rate. At the same time, by introducing a precise formula configuration, double decoction extraction, dynamic heating control and intelligent temperature iterative adjustment mechanism, the standardized and precise operation of key links in the process of traditional Chinese medicine preparation is realized. Especially in the decoction link, a temperature sensor is used to continuously monitor and dynamically adjust the heating parameters through a temperature value sequence, ensuring the full extraction and stable release of the effective components of the medicinal liquid, effectively improving the consistency of the medicinal effect and the controllability of the preparation process. In addition, the finished medicinal liquid is further purified through the processes of standing precipitation of the medicinal liquid and supernatant sub-packaging, improving the safety and the sustainability of the effect. The overall solution significantly enhances the standardization degree of traditional Chinese medicine preparation for psoriasis related to tonsillitis, and effectively enhances the controllability of the preparation and the consistency of the medicinal effect.
[0017] The above description is only an overview of the technical solution of the present application. In order to be able to understand the technical means of the present application more clearly, it can be implemented in accordance with the content of the specification. And in order to make the above and other purposes, features and advantages of the present application more obvious and understandable, the specific embodiments of the present application are specifically exemplified below. Description of the Drawings
[0018] Figure 1 It is a schematic flow chart of a preparation method of a traditional Chinese medicine formula for treating psoriasis related to tonsillitis provided by an embodiment of the present application.
[0019] Figure 2 It is a schematic flow chart of obtaining a corrected second heating parameter in a preparation method of a traditional Chinese medicine formula for treating psoriasis related to tonsillitis provided by an embodiment of the present application. Detailed Description of the Invention
[0020] By providing a traditional Chinese medicine formula and a preparation method for treating psoriasis related to tonsillitis, the embodiment of the present application solves the technical problem that the prior art lacks a traditional Chinese medicine formula for psoriasis related to tonsillitis, and achieves the technical effect of providing a traditional Chinese medicine formula that can effectively eliminate the symptoms of psoriasis related to tonsillitis and reduce the recurrence rate.
[0021] Embodiment 1. The embodiment of the present application provides a traditional Chinese medicine formula for treating psoriasis related to tonsillitis. The traditional Chinese medicine formula is made from the following components and their parts by weight: 8-12 parts of cicada slough, 8-12 parts of bombyx batryticatus, 12-18 parts of lithospermum root, 8-12 parts of duckweed, 12-18 parts of rubia cordifolia, 12-18 parts of verbena officinalis, 12-18 parts of smilax glabra, 8-12 parts of nidus vespae, 12-18 parts of oldenlandia diffusa, and 12-18 parts of scutellaria barbata.
[0022] Furthermore, the specific weight portions of the traditional Chinese medicine formula are as follows: 10 parts of cicada slough, 10 parts of bombyx batryticatus, 15 parts of lithospermum erythrorhizon, 10 parts of duckweed, 15 parts of rubia cordifolia, 15 parts of verbena officinalis, 15 parts of smilax glabra, 10 parts of nidus vespae, 15 parts of hedyotis diffusa, and 15 parts of scutellaria barbata. Among them, the functions, main indications, and synergistic effects of each medicinal material are as follows: Cicada slough: sweet and cold, belonging to the lung and liver meridians; dispersing wind-heat, relieving sore throat and promoting eruption, can relieve skin itching. Bombyx batryticatus: salty, pungent, and flat, belonging to the liver and lung meridians; expelling wind to stop convulsion, resolving phlegm and dissipating nodules, can inhibit inflammatory reactions. Lithospermum erythrorhizon: sweet and cold, belonging to the heart and liver meridians; cooling blood and promoting blood circulation, detoxifying and promoting eruption, can improve erythema of blood-heat type. Duckweed: pungent and cold, belonging to the lung meridian; inducing sweating to relieve exterior syndrome, promoting eruption and relieving itching, can assist in dispersing wind-heat. Rubia cordifolia: bitter and cold, belonging to the liver meridian; cooling blood and removing stasis, dredging channels and activating collaterals, can promote the regression of skin lesions. Verbena officinalis: bitter and cool, belonging to the liver and spleen meridians; clearing heat and detoxifying, promoting blood circulation to remove stasis, can inhibit tonsil inflammation. Smilax glabra: sweet, light, and flat, belonging to the liver and stomach meridians; detoxifying and removing dampness, dredging channels and promoting joint movement, can regulate immune disorders. Nidus vespae: sweet and flat, belonging to the stomach meridian; attacking toxins to kill insects, expelling wind and relieving pain, can enhance local anti-inflammatory effects. Hedyotis diffusa: slightly bitter, sweet, and cold, belonging to the stomach, large intestine, and small intestine meridians; clearing heat and detoxifying, promoting diuresis and reducing swelling, can regulate immunity bidirectionally. Scutellaria barbata: pungent and flat, belonging to the lung, liver, and kidney meridians; clearing heat and detoxifying, removing stasis and stopping bleeding, can synergistically inhibit the spread of lesions.
[0023] In summary, the traditional Chinese medicine formula for treating psoriasis related to tonsillitis described in the embodiments of the present application, through the compatibility idea of "expelling wind and promoting eruption, cooling blood and detoxifying", can effectively eliminate the symptoms of psoriasis, reduce the recurrence rate, and at the same time has rapid curative effect and high safety for psoriasis of wind-heat injuring collaterals type induced by tonsillitis.
[0024] Example 2, as Figure 1 shown, based on the same inventive concept of the above traditional Chinese medicine formula for treating psoriasis related to tonsillitis, the embodiments of the present application provide a preparation method of a traditional Chinese medicine formula for treating psoriasis related to tonsillitis, and the method includes:
[0025] Step S100: Configure medicinal materials according to the first ratio of the preset traditional Chinese medicine formula, and perform soaking treatment on the configured medicinal materials.
[0026] Specifically, according to the first ratio of the preset traditional Chinese medicine formula, accurately weigh each medicinal material and wash it clean, then put it into clear water for soaking. The soaking water volume is preferably 2-3 cm above the surface of the medicinal materials to make the medicinal materials fully absorb water and expand, facilitating the dissolution of active ingredients during subsequent decoction. Among them, the first ratio of the preset traditional Chinese medicine formula is calculated by weight, and the specific weight portions are as follows: 10 parts of cicada slough, 10 parts of bombyx batryticatus, 15 parts of lithospermum erythrorhizon, 10 parts of duckweed, 15 parts of rubia cordifolia, 15 parts of verbena officinalis, 15 parts of smilax glabra, 10 parts of nidus vespae, 15 parts of hedyotis diffusa, and 15 parts of scutellaria barbata.
[0027] Step S200: When the soaking time meets the preset soaking time, pour the soaked medicinal materials and soaking water into a container, and add clear water to the container until the first preset water volume constraint is met, obtaining a first container to be heated that is ready.
[0028] Furthermore, the preset soaking time is the soaking duration set according to the properties of the medicinal materials and experience, and is set to 30 minutes to ensure the full extraction of the effective components of the medicinal materials. The first preset water volume constraint refers to the total amount of the soaking water poured into the container and the added clear water. The first preset water volume constraint is that the water volume in the container is 8 times the weight of the medicinal materials before soaking.
[0029] Specifically, when the soaking reaches the preset soaking time (30 minutes), pour the soaked medicinal materials and the soaking water together into a decocting container, such as a casserole or a stainless-steel pot, and add clear water until the total water volume is 8 times the weight of the medicinal materials (for example, if the total medicinal materials are 150 g, add water to 1200 g), obtaining a first container to be heated that is ready, and preparing for the subsequent decocting process. Among them, iron and aluminum utensils are prohibited from being used in the decocting container. This step ensures that there is enough water for subsequent full decoction, and at the same time, the precise control of the water volume is also beneficial to the stability of the subsequent medicinal liquid concentration.
[0030] Step S300: Obtain the basic information of the heater, combine the characteristics of cicada slough, bombyx batryticatus, duckweed, and nidus vespae in the preset traditional Chinese medicine formula, determine the first heating parameter of the heater, and determine the second heating parameter of the heater according to the basic information and the characteristics of lithospermum root, rubia cordifolia, verbena officinalis, smilax glabra, oldenlandia diffusa, and scutellaria barbata in the preset traditional Chinese medicine formula.
[0031] Specifically, the basic information of the heater refers to the basic characteristic data of the heater itself, such as the maximum heating power, the lowest and highest heating temperatures, the temperature control accuracy, the power curve, the heating response time (the delay characteristic of the temperature change and the power change), etc. This information generally comes from the technical manual of the heater or is obtained through equipment self-check. The first heating parameter refers to the parameter setting for quickly heating the medicinal liquid to boiling at a higher heating power. The second heating parameter refers to the parameter setting for maintaining gentle heating in a slightly boiling state.
[0032] First, it is necessary to extract the basic information of the heater from the heating device, which can be confirmed by reading the data interface of the heater device, querying the device manual, or through experimental means (such as setting an initial power and observing the temperature change curve). Subsequently, combined with the medicinal properties of different herbs in the traditional Chinese medicine formula, the target temperatures for the two heating stages are determined respectively. For herbs such as cicada slough, bombyx batryticatus, duckweed, and nidus vespae, because of their light texture and easy release of active ingredients, they usually do not require long-term high-temperature decoction. For example, the active ingredients of cicada slough are relatively volatile and need to be rapidly released at a relatively high temperature in a short time; bombyx batryticatus contains a certain amount of protein components, and long-term high temperature may cause some of its components to denature, so it is suitable for high-temperature extraction first; duckweed is light in texture and the dissolution rate of active ingredients is relatively fast. Therefore, for these herbs, it is necessary to quickly heat to the boiling point of the liquid at full power. For herbs such as lithospermum erythrorhizon, rubia cordifolia, verbena officinalis, smilax glabra, oldenlandia diffusa, and scutellaria barbata, the active ingredients need to be decocted at a certain temperature for a long time to be fully dissolved. For example, some fat-soluble components in lithospermum erythrorhizon and some polysaccharide components in smilax glabra need to be continuously heated with slow fire. According to the characteristics of the herbs in the preset traditional Chinese medicine formula, two heating stages are set. In the first stage, strong fire is used for heating, and the target temperature is 100°C (standard boiling temperature); in the second stage, slow fire is used for heating, and the target temperature is set within the range of 95°C to 98°C, maintaining a gentle boil.
[0033] Combining the basic information of the heater and the target temperatures of the two heating stages, the first heating parameter and the second heating parameter are set. Among them, the first heating parameter is set as follows: the heating power is set to the maximum or close to the maximum, the heating mode is continuous heating without segmented adjustment; the heating-up curve is set in a rapid-rising mode. The second heating parameter is set as follows: the heating power is reduced to a low gear, such as 50% to 80%, and a pulse heating mode or a small-power continuous heating mode is adopted (selected according to the characteristics of the heater); the heating response needs to be gentle to avoid large fluctuations in temperature. By dynamically switching through different parameter groups in the initial heating stage and the middle and late heating stages, it can effectively avoid the inactivation or excessive volatilization of the initial components of the herbs, and at the same time ensure the full release of the active ingredients in the later stage, thereby improving the extraction rate of the active ingredients in traditional Chinese medicine decoction and the stability and reliability of the final medicinal effect.
[0034] Step S400: Heat the first container to be heated according to the first heating parameter until it boils, and obtain a first parameter adjustment instruction.
[0035] Specifically, the first parameter adjustment instruction is an instruction triggered when the liquid medicine reaches the boiling state, which is used to adjust the heater parameters subsequently, such as reducing the firepower. Place the first container to be heated on the heater, set the initial heating parameter as the first heating parameter, turn on the heater to heat the container, and when the liquid medicine starts to boil, generate and output the first parameter adjustment instruction. This step quickly brings the liquid medicine to the boiling state, prepares for adjusting the firepower for slow-fire decoction subsequently, and is conducive to the full dissolution of the active ingredients.
[0036] Step S500: Adjust the parameters of the heater to the second heating parameters according to the first parameter adjustment instruction, continuously monitor the temperature of the first container to be heated, and perform feedback adjustment on the second heating parameters according to the monitoring results until the first preset duration is satisfied, stop heating, filter the first container to be heated, and obtain the first filtered medicinal residues and the first collected medicinal liquid.
[0037] Specifically, after receiving the first parameter adjustment instruction, adjust the parameters of the heater to the second heating parameters, that is, in the state of gentle fire (low fire). Subsequently, use a temperature sensor to continuously monitor the temperature inside the container. The monitoring frequency can be set to once per second or once every 10 seconds. According to the collected real-time temperature values, perform feedback adjustment on the second heating parameters. If the temperature is higher than the target upper limit, appropriately reduce the heating power; if the temperature is lower than the target lower limit, appropriately increase the heating power. In this feedback-controlled gentle-fire decocting mode, heat the first container to be heated continuously for the first preset duration and then turn off the heater. The first preset duration is set to 40 minutes. Use a filtering tool such as a filter net or gauze to filter the medicinal liquid in the decocting container to obtain the first collected medicinal liquid, and the remaining solid substance is the first filtered medicinal residues. In this step, by continuously heating with gentle fire, the medicinal liquid is fully decocted, so that more active ingredients are dissolved into the medicinal liquid. During the continuous heating process, the heating time error needs to be controlled within ±5 minutes to avoid the volatilization of active ingredients or insufficient precipitation.
[0038] Further, step S500 includes:
[0039] Step S510: Adjust the parameters of the heater to the second heating parameters according to the first parameter adjustment instruction, and use a temperature sensor to continuously monitor the temperature of the first container to be heated within a preset monitoring window to obtain a sequence of monitored temperature values.
[0040] Step S520: Perform iterative adjustment on the second heating parameters according to the sequence of monitored temperature values to obtain a corrected second heating parameter, and adjust the parameters of the heater according to the corrected second heating parameter.
[0041] Specifically, after the medicinal liquid reaches the boiling state and the first parameter adjustment instruction is issued, adjust the parameters of the heater to the second heating parameters, that is, lower the temperature or power of the heater for gentle-fire decocting. Then place the temperature sensor (such as a thermocouple temperature sensor) near the first container to be heated or insert it into a suitable position in the medicinal liquid (note that it cannot affect the quality and safety of the medicinal liquid), turn on the temperature sensor, continuously monitor the temperature of the medicinal liquid within a preset monitoring window (such as 3 minutes), record the temperature value at regular time intervals (such as every 10 seconds), and form a sequence of monitored temperature values.
[0042] Based on the obtained monitored temperature value sequence, the second heating parameter is iteratively optimized and adjusted through an optimization algorithm to obtain a corrected second heating parameter, and then the heater is reset according to this corrected second heating parameter, so that the temperature of the liquid medicine is more stable during the decocting process, thereby ensuring that the medicinal efficacy components can be fully and stably dissolved and improving the stability of the quality of the liquid medicine.
[0043] Further, as Figure 2 shown, step S520 includes:
[0044] Step S521: Traverse the monitored temperature value sequence to extract the mode and determine the representative monitored temperature value.
[0045] Step S522: Calculate the fluctuation variance of the monitored temperature value sequence and determine the iteration bandwidth according to the calculation result.
[0046] Step S523: Based on the iteration bandwidth, construct a first representative neighborhood of the representative monitored temperature value in the monitored temperature value sequence.
[0047] Step S524: Iteratively expand the first representative neighborhood according to the iteration bandwidth until a preset iteration expansion stop condition is met to obtain a target representative neighborhood.
[0048] Step S525: Calculate the mean value of the target representative neighborhood to obtain the target monitored temperature value.
[0049] Step S526: Adjust the second heating parameter according to the target monitored temperature value to obtain the corrected second heating parameter.
[0050] Further, the difference between any monitored temperature value in the first representative neighborhood and the representative monitored temperature value is less than or equal to the iteration bandwidth.
[0051] Specifically, traverse the monitored temperature value sequence, sequentially view each temperature value in the monitored temperature value sequence, count the frequency of occurrence of the temperature value, find the temperature value (mode) with the most occurrences, and output it as the representative monitored temperature value, which can reflect the central tendency of the monitored temperature value sequence to a certain extent and represents a typical value of the monitored temperature value sequence.
[0052] Then, calculate the fluctuation variance of the monitored temperature value sequence. Taking the monitored temperature value sequence (95°C, 96°C, 95°C, 97°C, 95°C, 96°C, 95°C) as an example, first calculate its average value as (95 + 96 + 95 + 97 + 95 + 96 + 95) / 7 ≈ 95.57°C. Then calculate the square of the difference between each temperature value and the average value, and then find the average of these squares, and the obtained variance is about 0.81. According to this variance value, set the iterative bandwidth. For example, according to the pre-set rules, when the variance is between 0 and 1, the iterative bandwidth is set to 1°C; when the variance is between 1 and 2, the iterative bandwidth is set to 2°C. It should be noted that the monitored temperature value sequence here is for the convenience of those skilled in the art to understand and the data has been simplified.
[0053] Taking the representative monitored temperature value as the center and the iterative bandwidth as the radius, determine a range interval in the monitored temperature value sequence. The temperature values within this interval do not differ from the representative monitored temperature value by more than the iterative bandwidth, and these temperature values constitute the first representative neighborhood. Still taking the above-mentioned monitored temperature value sequence as an example, the representative monitored temperature value is (the mode) 95°C, and the iterative bandwidth is taken as 1°C, then the first representative neighborhood is the area where the temperature is between 94°C and 96°C.
[0054] Taking the neighborhood density as a condition, gradually expand the range of the first representative neighborhood based on the iterative bandwidth until the pre-set stop condition is met, that is, the pre-set iterative expansion stop condition. The iterative expansion stop condition can be set as the neighborhood density (the degree of distribution density of temperature values) threshold to obtain the target representative neighborhood.
[0055] Add up all the temperature values within the target representative neighborhood, and then divide by the number of temperature values to obtain the average temperature value. Take this temperature average value as the target monitored temperature value, which can better reflect the actual temperature situation in the current decocting process and provide a more accurate basis for adjusting the heating parameters subsequently.
[0056] Adjust the second heating parameter according to the difference between the target monitored temperature value and the desired temperature, and the pre-set adjustment rules. For example, when the target temperature is higher than the desired temperature, appropriately reduce the power of the heater according to the characteristics of the heater. The adjustment process can be completed based on a PID control system.
[0057] Further, step S524 includes:
[0058] Step S524-1: Expand the first representative neighborhood according to the iterative bandwidth to obtain a second representative neighborhood.
[0059] Step S524-2: Determine whether the neighborhood density of the second representative neighborhood is greater than or equal to the neighborhood density of the first representative neighborhood. If so, continue to iteratively expand the second representative neighborhood until the pre-set iterative expansion stop condition is met to obtain the target representative neighborhood.
[0060] Further, when the neighborhood density of the second representative neighborhood is less than that of the first representative neighborhood, the first representative neighborhood is taken as the target representative neighborhood.
[0061] Specifically, when iteratively expanding the first representative neighborhood, first, centered on the first representative neighborhood, expand the temperature range of one iteration bandwidth to both sides, re-stat the monitored temperature values included in the new range, and form a new neighborhood set, that is, the second representative neighborhood.
[0062] Then calculate the neighborhood densities of the second representative neighborhood and the first representative neighborhood. Among them, the neighborhood density refers to the number of monitored temperature data points included in the unit temperature range and is used to measure the concentration of data in the neighborhood. The calculation formula is as follows: neighborhood density = number of temperature points in the neighborhood / neighborhood temperature span. Compare the neighborhood density of the second representative neighborhood with that of the first representative neighborhood. If the neighborhood density of the second representative neighborhood is greater than or equal to that of the first representative neighborhood, continue to iteratively expand the second representative neighborhood, that is, centered on the second representative neighborhood, expand the temperature range of one iteration bandwidth to both sides to obtain a new representative neighborhood, and perform neighborhood density judgment. Loop the above iterative expansion process until the preset iterative expansion stop condition is met to obtain the target representative neighborhood. If the neighborhood density of the second representative neighborhood is less than that of the first representative neighborhood, the first representative neighborhood is taken as the target representative neighborhood.
[0063] The above steps introduce a density-dominated iterative neighborhood expansion mechanism, which is both adaptive and can avoid the deviation caused by mis-expansion during the process of extracting the temperature stable interval, and finally provides a more representative thermal feedback basis for the adjustment of temperature control parameters, significantly enhancing the temperature control accuracy of traditional Chinese medicine decoction.
[0064] Step S600: Perform secondary decoction on the first filtered medicinal residues to obtain the second collected medicinal liquid.
[0065] Specifically, the first filtered medicinal residues refer to the solid residues remaining after filtration in step S400, which may still contain some active ingredients that have not been fully dissolved. Put the medicinal residues obtained from the first filtration back into a clean container (which can be the decoction container used before), add an appropriate amount of clear water, and the water volume meets the second preset water volume constraint (a little less than the water volume during the first decoction), and heat and decoct again with a heater. The operation method is similar to that of the first decoction, but only the decoction time is slightly adjusted. For example, after heating with slow fire for about 30 minutes, filter to obtain the second collected medicinal liquid. This step fully excavates the residual active ingredients in the medicinal residues, improves the utilization rate of medicinal materials in the whole preparation process, and enhances the overall medicinal effect of the medicinal liquid.
[0066] Further, step S600 includes:
[0067] Step S610: placing the first filtered medicinal residue in a container, adding clean water into the container until a second preset water volume constraint is met, and obtaining a second container to be heated.
[0068] Step S620: using a heater to heat the second container to be heated according to the first heating parameter until it is heated to boiling, and obtaining a second parameter adjustment instruction.
[0069] Step S630: adjusting the parameters of the heater to the second heating parameters according to the second parameter adjustment instruction, heating the second container to be heated for a second preset time period using the heater with adjusted parameters, then stopping heating, filtering the second container to be heated, and obtaining the second collected medicinal solution.
[0070] Specifically, put the first filtered medicinal residue into a clean container, add water according to the second preset water volume constraint, the second preset water volume constraint should be smaller than the first preset water volume constraint, and is generally set to 6 times the initial medicinal material weight (such as 150g of total medicinal materials, add water to 900g), obtain the second container to be heated, and prepare for the second decoction.
[0071] Place the second container to be heated on the heater, set the heater to the first heating parameter, turn on the heater to heat the container, and when the medicinal liquid begins to boil, issue a second parameter adjustment instruction. After adjusting the parameters of the heater to the second heating parameter according to the second parameter adjustment instruction, continue heating for the second preset time, and then stop heating. Among them, the second preset time is set to 30 minutes, and the heater parameter adjustment control process here can refer to step S500. After the heating is completed, use a filter or gauze and other tools to filter the decocted medicinal liquid, and collect the second collected medicinal liquid.
[0072] Step S700: The first collected medicinal solution and the second collected medicinal solution are combined and allowed to settle, and the supernatant is taken for subpackaging to obtain a prepared subpackaged Chinese medicine collection.
[0073] Specifically, pour the first collected liquid medicine and the second collected liquid medicine into a clean container together, let it stand to allow impurities to settle, then take out the supernatant by siphoning or carefully pouring, and then use a filling device (such as an automatic filling machine or a manual filling tool) to fill the supernatant into packaging bottles at a volume of about 200 to 250 ml per bottle, and finally obtain a collection of packaged Chinese medicines for the treatment of psoriasis. This step removes impurities in the liquid medicine, improves the purity of the liquid medicine, and makes the liquid medicine easier to store and take. If short-term storage is required, the liquid medicine can be sealed and refrigerated at a temperature of 2°C to 8°C for no more than 48 hours.
[0074] The specific case data are as follows:
[0075] Typical case 1: Shi, male, 13 years old, from Economic Development Zone, Xi'an, Shaanxi Province, was diagnosed with psoriasis because of papules and scales all over the body for more than 4 months. He was prone to exogenous infection and tonsillitis. Oral silver psoriasis capsules, transfer factor, external application of desonide, tacalcitol, etc. were ineffective in other hospitals. After taking the drug of the present invention, the papules and scales on the body disappeared after 4 weeks of treatment.
[0076] Typical case 2: Wang, male, 6 years old, from Beilin District, Xi'an City, Shaanxi Province, was diagnosed with psoriasis for 1 month due to widespread erythematous papules all over the body. He was prone to exogenous infections since childhood, had swollen tonsils, and ate a lot of spicy and sweet foods. After taking the drug of the present invention combined with tonsil branding for 2 months, the papules and scales all over the body disappeared.
[0077] Typical case 3: Li, female, 10 years old, from Xi'an, Shaanxi Province, sought medical treatment due to systemic generalized papular erythema with scaling for more than one year. She was diagnosed with psoriasis with swollen tonsils. After taking the medicine of the present invention combined with tonsil branding for 4 months, her systemic symptoms subsided.
[0078] In summary, the method for preparing a Chinese medicine formula for treating psoriasis associated with tonsillitis provided in the embodiments of the present application has the following beneficial effects:
[0079] The embodiment of the present application realizes the standardization and precision operation of key links in the preparation process of traditional Chinese medicine by introducing precise configuration of formula, double decoction extraction, dynamic heating control and intelligent temperature iteration adjustment mechanism. Especially in the decoction process, the temperature sensor is used for continuous monitoring and the heating parameters are dynamically adjusted through the temperature value sequence to ensure the full extraction and stable release of the effective ingredients of the liquid medicine, and effectively improve the consistency of the efficacy and the controllability of the preparation process. In addition, the finished liquid medicine is further purified by the static precipitation of the liquid medicine and the supernatant packaging process, which improves the safety and sustainability of the effect. The overall solution significantly enhances the adaptability and targeting of the traditional Chinese medicine preparation process to specific syndromes of psoriasis, improves the degree of preparation standardization, and effectively enhances the controllability of the preparation and the consistency of the efficacy.
[0080] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.
Claims
1. A traditional Chinese medicine formula for treating psoriasis related to tonsillitis, characterized in that, The Chinese medicine formula is prepared from the following components and their weight portions: 8-12 parts of cicada slough, 8-12 parts of bombyx batryticatus, 12-18 parts of lithospermum officinale, 8-12 parts of duckweed, 12-18 parts of madder, 12-18 parts of verbena, 12-18 parts of smilax glabra, 8-12 parts of beehive, 12-18 parts of oldenlandia diffusa, and 12-18 parts of Scutellaria barbata.
2. The traditional Chinese medicine composition for treating psoriasis related to tonsillitis according to claim 1, characterized in that, The specific weight portions of the Chinese medicine formula are as follows: 10 parts of cicada slough, 10 parts of silkworm pupa, 15 parts of lithospermum officinale, 10 parts of duckweed, 15 parts of madder, 15 parts of verbena, 15 parts of smilax glabra, 10 parts of beehive, 15 parts of oldenlandia diffusa, and 15 parts of Scutellaria barbata.
3. A preparation method of a traditional Chinese medicine formula for treating psoriasis related to tonsillitis, characterized in that, The method comprises: Prepare medicinal materials according to the first ratio of the preset Chinese medicine formula, and soak the prepared medicinal materials; When the soaking time meets the preset soaking time, the soaked medicinal materials and the soaking water are poured into the container, and clean water is added to the container until the first preset water volume constraint is met, thereby obtaining a first container to be heated; Obtaining basic information of the heater, determining a first heating parameter of the heater in combination with the characteristics of cicada slough, silkworm, duckweed and honeycomb in the preset Chinese medicine formula, and determining a second heating parameter of the heater according to the basic information and the characteristics of lithospermum officinale, madder, verbena, smilax glabra, oldenlandia diffusa and Scutellaria barbata in the preset Chinese medicine formula; Heating the first container to be heated according to a first heating parameter until it is heated to boiling, and obtaining a first parameter adjustment instruction; According to the first parameter adjustment instruction, the parameter of the heater is adjusted to the second heating parameter, the temperature of the first container to be heated is continuously monitored, and the second heating parameter is feedback-adjusted according to the monitoring result until the first preset time is met, the heating is stopped, and the first container to be heated is filtered to obtain the first filtered medicinal residue and the first collected medicinal liquid; The first filtered medicinal residue is decocted for a second time to obtain a second collected medicinal liquid; The first collected medicinal solution and the second collected medicinal solution are combined and allowed to settle, and the supernatant is taken out for subpackaging to obtain a prepared subpackaged Chinese medicine collection.
4. The preparation method of a traditional Chinese medicine formula for treating psoriasis related to tonsillitis according to claim 3, characterized in that, Adjusting the parameters of the heater according to the first parameter adjustment instruction includes: Using a temperature sensor to continuously monitor the temperature of the first container to be heated within a preset monitoring window to obtain a monitoring temperature value sequence; The second heating parameter is iteratively adjusted according to the monitored temperature value sequence to obtain a modified second heating parameter, and the heater is parameter adjusted according to the modified second heating parameter.
5. The preparation method of a traditional Chinese medicine prescription for treating psoriasis related to tonsillitis according to claim 4, characterized in that, Iteratively adjusting the second heating parameter according to the monitored temperature value sequence to obtain a modified second heating parameter includes: Traversing the monitoring temperature value sequence to extract the mode and determine a representative monitoring temperature value; Calculating the fluctuation variance of the monitored temperature value sequence, and determining the iteration bandwidth according to the calculation result; constructing the first representative neighborhood representing the monitored temperature value in the monitored temperature value sequence based on the iteration bandwidth; Iteratively expanding the first representative neighborhood according to the iteration bandwidth until a preset iterative expansion stop condition is met to obtain a target representative neighborhood; Calculate the mean of the target representative neighborhood to obtain the target monitoring temperature value; Adjust the second heating parameter according to the target monitored temperature value to obtain the corrected second heating parameter.
6. The preparation method of a traditional Chinese medicine formula for treating psoriasis related to tonsillitis according to claim 5, characterized in that The difference between any monitored temperature value in the first representative neighborhood and the representative monitored temperature value is less than or equal to the iteration bandwidth.
7. The preparation method of a traditional Chinese medicine formula for treating psoriasis related to tonsillitis according to claim 5, characterized in that, Iteratively expand the first representative neighborhood according to the iteration bandwidth until a preset iteration expansion stop condition is satisfied to obtain a target representative neighborhood, including: Expand the first representative neighborhood according to the iteration bandwidth to obtain a second representative neighborhood; Judge whether the neighborhood density of the second representative neighborhood is greater than or equal to the neighborhood density of the first representative neighborhood. If so, continue to iteratively expand the second representative neighborhood until a preset iteration expansion stop condition is satisfied to obtain the target representative neighborhood.
8. The preparation method of a traditional Chinese medicine formula for treating psoriasis related to tonsillitis according to claim 7, characterized in that, When the neighborhood density of the second representative neighborhood is less than the neighborhood density of the first representative neighborhood, use the first representative neighborhood as the target representative neighborhood.
9. The preparation method of a traditional Chinese medicine formula for treating psoriasis related to tonsillitis according to claim 3, characterized in that, Perform secondary decoction on the first filtered medicinal residues to obtain the second collected medicinal liquid, including: Place the first filtered medicinal residues in a container, add clear water to the container until a second preset water volume constraint is satisfied to obtain a second container to be heated; Use a heater to heat the second container to be heated according to the first heating parameter until it boils to obtain a second parameter adjustment instruction; Adjust the parameters of the heater to the second heating parameter according to the second parameter adjustment instruction, continuously heat the second container to be heated with the parameter-adjusted heater for a second preset duration, then stop heating, and filter the second container to be heated to obtain the second collected medicinal liquid.
10. The preparation method of a traditional Chinese medicine formula for treating psoriasis related to tonsillitis according to claim 3, characterized in that, The first preset water volume constraint is that the water volume in the container is 8 times the weight of the medicinal materials before soaking.