Capillary electrophoresis instrument

Abstract

The present invention provides a capillary electrophoresis instrument, which has a laser light source, an ultraviolet light source and a dichroic mirror. The light emitted by the laser light source is irradiated onto the transmission surface of the dichroic mirror, and after being transmitted by the dichroic mirror, it is focused onto the transmission optical fiber through a second focusing convex lens. Alternatively, the light emitted by the ultraviolet light source is converged into an integrated light beam by the second focusing convex lens, and then irradiated onto the reflection surface of the dichroic mirror. After being reflected by the dichroic mirror, it is focused onto the transmission optical fiber through the second focusing convex lens. Then the light passes through the capillary and is transmitted to the photoelectric sensor through the receiving optical fiber. When in use, it is only necessary to select the corresponding light source according to needs, and the detection of multiple substances with different absorption peaks can be achieved through one device without replacing accessories, which is lower in cost and simpler to operate. In addition, the present invention adopts multiple photoelectric sensors, and one optical fiber can be connected to one photoelectric sensor. Detection is achieved based on optical path signals, which can effectively improve the sensitivity of detection.

Description

Technical Field

[0001] The present invention relates to the technical field of biomedicine detection, in particular to a capillary electrophoresis instrument. Background Art

[0002] Capillary electrophoresis technology, also known as high-performance capillary electrophoresis, is a general term for a type of liquid phase separation analysis method and technology that uses capillaries as separation channels and a DC high-voltage electric field as the driving force, based on the sample's charge, size, isoelectric point, polarity, affinity behavior, phase distribution and other characteristics.

[0003] Capillary electrophoresis is one of the commonly used devices in biomedical testing. For example, when verifying the effectiveness of biomedicine, the capillary electrophoresis instrument can be used to detect the content of certain proteins in the human body, and the treatment effect can be verified based on the changes in protein content in the human body before and after medication.

[0004] However, existing capillary electrophoresis instruments are typically only capable of detecting a single or small number of substances. For example, detecting different types of proteins requires replacing related accessories, which is costly and cumbersome. Furthermore, existing capillary electrophoresis instruments typically use CMOS sensors and image analysis to perform detection. In multi-channel detection, multiple optical fibers are connected to a single CMOS sensor, resulting in low sensitivity. Summary of the Invention

[0005] Therefore, the purpose of the present invention is to provide a capillary electrophoresis instrument to solve the problems of high cost and complicated operation in the prior art when detecting various types of substances, and to improve the detection sensitivity.

[0006] A capillary electrophoresis instrument comprises an optical path module and a core detection module; the optical path module comprises an optical path base plate, and an ultraviolet light source assembly, a dichroic mirror assembly, a laser light source assembly, a focusing lens assembly, and a transmission optical fiber assembly mounted on the optical path base plate;

[0007] The ultraviolet light source assembly includes an ultraviolet light source and a first focusing convex lens, wherein the first focusing convex lens is installed on the output light path of the ultraviolet light source; the dichroic mirror assembly includes a dichroic mirror; the laser light source assembly includes a laser light source; the focusing lens assembly includes a second focusing convex lens, and the transmission fiber assembly includes a plurality of transmission fibers; the dichroic mirror is fixed to the optical path base plate at a preset angle; the reflective surface of the dichroic mirror faces the ultraviolet light source, and the transmissive surface of the dichroic mirror faces the laser light source;

[0008] The core detection module includes a capillary base plate, a plurality of photoelectric sensors and a plurality of receiving optical fibers. The capillary base plate is provided with an optical fiber lower guide plate and a plurality of capillary tube assemblies. The bottom of the capillary base plate is provided with an anode pool and a cathode pool. The optical fiber lower guide plate is provided with a plurality of slots for placing transmission optical fibers. Each capillary tube assembly includes a capillary tube, one end of the capillary tube is inserted into the anode pool, and the other end is inserted into the cathode pool. The capillary tube is located between the transmission optical fiber and the receiving optical fiber, and the receiving optical fiber is electrically connected to the photoelectric sensor.

[0009] The light emitted by the laser light source is irradiated onto the transmission surface of the dichroic mirror, and after being transmitted through the dichroic mirror, is focused onto the transmission optical fiber by the second focusing convex lens. After passing through the capillary tube, the light is transmitted to the photoelectric sensor through the receiving optical fiber.

[0010] Alternatively, the light emitted by the ultraviolet light source is converged into an integrated light beam by the first focusing convex lens, irradiated onto the reflective surface of the dichroic mirror, reflected by the dichroic mirror, and focused onto the transmission optical fiber by the second focusing convex lens. After passing through the capillary, the light is transmitted to the photoelectric sensor through the receiving optical fiber.

[0011] According to the capillary electrophoresis instrument provided by the present invention, since a laser light source, an ultraviolet light source and a dichroic mirror are provided, the light emitted by the laser light source is irradiated onto the transmission surface of the dichroic mirror, and after being transmitted by the dichroic mirror, it is focused onto the transmission optical fiber through the second focusing convex lens. Alternatively, the light emitted by the ultraviolet light source is converged into an integrated light beam by the second focusing convex lens, and then irradiated onto the reflection surface of the dichroic mirror, and after being reflected by the dichroic mirror, it is focused onto the transmission optical fiber through the second focusing convex lens. Then the light passes through the capillary and is transmitted to the photoelectric sensor through the receiving optical fiber. When in use, it is only necessary to select the corresponding light source according to needs, and the detection of multiple substances with different absorption peaks can be achieved through one device without replacing accessories, lower cost and simple operation. In addition, the present invention adopts multiple photoelectric sensors, and one optical fiber can be connected to one photoelectric sensor. The photoelectric sensor realizes detection based on the optical path signal, which can effectively improve the detection sensitivity. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 1 is a schematic structural diagram of a capillary electrophoresis apparatus according to an embodiment of the present invention;

[0013] Figure 2 This is a structural diagram of the optical path module at the first viewing angle;

[0014] Figure 3 is a structural diagram of the optical path module at a second viewing angle;

[0015] Figure 4 This is a schematic diagram of the explosion structure of the core detection module;

[0016] Figure 5 This is a schematic diagram of the internal structure of the core detection module;

[0017] Figure 6 yes Figure 5 Enlarged view of point A in the middle;

[0018] Figure 7 1 is a schematic structural diagram of the optical fiber lower guide plate;

[0019] Figure 8 is a schematic structural diagram of a capillary assembly;

[0020] Figure 9 1. It is a schematic structural diagram of a capillary groove plate, a capillary and a fixing component;

[0021] Figure 10 It is a structural diagram of the fixed component;

[0022] Figure 11 It is a structural schematic diagram of the first capillary fixing plate, the second optical fiber fixing seat, the mounting base and the capillary;

[0023] Figure 12 It is a structural diagram of a photoelectric sensor. DETAILED DESCRIPTION

[0024] To make the above-mentioned objects, features, and advantages of the present invention more readily apparent, the following detailed description of specific embodiments of the present invention is provided in conjunction with the accompanying drawings. The accompanying drawings illustrate several embodiments of the present invention. However, the present invention may be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and comprehensive understanding of the present invention.

[0025] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may also be an element centered thereon. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may also be an element centered thereon. The terms "vertical", "horizontal", "left", "right", "up", "down" and similar expressions used herein are for illustrative purposes only and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore should not be understood as limiting the present invention.

[0026] In the present invention, unless otherwise expressly specified or limited, terms such as "installed," "connected," "connect," and "fixed" should be understood broadly. For example, they may refer to fixed, removable, or integral connections; mechanical or electrical connections; direct or indirect connections through an intermediary; or internal communication between two components. Those skilled in the art will understand the specific meanings of these terms in the present invention based on the specific circumstances. As used herein, the term "and / or" includes any and all combinations of one or more of the relevant listed items.

[0027] See also Figures 1 to 12 A capillary electrophoresis instrument provided by an embodiment of the present invention includes an optical path module 10 and a core detection module 20.

[0028] The optical path module 10 includes an optical path base plate 11 , and an ultraviolet light source assembly 12 , a dichroic mirror assembly 13 , a laser light source assembly 14 , a focusing lens assembly 15 and a transmission optical fiber assembly 16 mounted on the optical path base plate 11 .

[0029] The ultraviolet light source assembly 12 includes an ultraviolet light source 121 , a first focusing convex lens 122 , an ultraviolet outer sleeve 123 , an ultraviolet adjustment sleeve 124 , an ultraviolet adjustment fixing block 125 , a slider 126 , and a slide rail 127 .

[0030] The ultraviolet light source 121 is installed in the ultraviolet outer sleeve 123 . In this embodiment, the ultraviolet light source 121 is a 280nm ultraviolet light source, and the first focusing convex lens 122 is installed on the outgoing light path of the ultraviolet light source 121 .

[0031] The ultraviolet outer sleeve 123 is installed in the ultraviolet adjustment sleeve 124, and the ultraviolet adjustment sleeve 124 is installed in the through hole on the ultraviolet adjustment fixing block 125 through adjusting bolts. Specifically, the adjusting bolts are symmetrically distributed in four directions to adjust the angle of the ultraviolet light.

[0032] The ultraviolet light adjustment fixing block 125 is fixed to the slider 126, and the slider 126 is mounted on the slide rail 127. The slide rail 127 is fixed to the optical path base plate 11, and the slider 126 can slide on the slide rail 127. By sliding the slide rail 127, the focus position of the ultraviolet light can be adjusted.

[0033] The dichroic mirror assembly 13 includes a dichroic mirror 131 and a dichroic mirror fixing block 132 . The dichroic mirror 131 is mounted on the dichroic mirror fixing block 132 . The dichroic mirror 131 is mounted on the dichroic mirror fixing block 132 . The dichroic mirror fixing block 132 is mounted on the optical path base plate 11 .

[0034] The laser light source assembly 14 includes a laser light source 141, a laser adjustment sleeve 142, and a laser adjustment fixing block 143. The laser light source 141 is mounted in the laser adjustment sleeve 142. In this embodiment, the laser light source 141 uses a 577nm laser light source. The 577nm laser light source and the 280nm ultraviolet light source form a dual excitation system.

[0035] The laser adjustment sleeve 142 is mounted on the laser adjustment fixing block 143 via adjustment bolts, and also uses adjustment bolts that are symmetrically distributed in four directions to adjust the laser angle.

[0036] The laser adjustment fixing block 143 is fixed on the optical path base plate 11 .

[0037] The focusing lens assembly 15 includes a second focusing convex lens 151 and a focusing lens fixing block 152 . The second focusing convex lens 151 is installed in the focusing lens fixing block 152 . The focusing lens fixing block 152 is fixed on the optical path base plate 11 .

[0038] The transmission optical fiber assembly 16 includes several transmission optical fibers 161, an optical fiber fixing silicone sleeve 162 and a transmission optical fiber fixing block 163. The transmission optical fiber 161 is installed in the optical fiber fixing silicone sleeve 162, the optical fiber fixing silicone sleeve 162 is installed on the transmission optical fiber fixing block 163, and the transmission optical fiber fixing block 163 is fixed on the optical path base plate 11.

[0039] The dichroic mirror 131 is fixed to the optical path base plate 11 at a preset angle; its reflective surface faces the ultraviolet light source 121, and its transmissive surface faces the laser light source 141. The dichroic mirror 131 is composed of multiple layers of thin films, each with a pre-designed thickness and refractive index to ensure a specific ratio of reflected and transmitted light at a specific wavelength. The dichroic mirror 131 used in this embodiment transmits 577nm laser light and reflects 280nm ultraviolet light.

[0040] The core detection module 20 includes a capillary base plate 21 , a plurality of receiving optical fibers 22 , and a plurality of photoelectric sensors 23 .

[0041] The capillary base plate 21 is provided with an optical fiber lower guide plate 24 and a plurality of capillary tube assemblies 25 .

[0042] An anode pool 261 and a cathode pool 262 are provided at the bottom of the capillary base plate 21, and a plurality of slots 241 are provided on the optical fiber lower guide plate 24. The slots 241 are used to place the transmission optical fiber 161. Each capillary assembly 25 includes a capillary 251. One end of the capillary 251 is inserted into the anode pool 261, and the other end is inserted into the cathode pool 262. The anode pool 261 and the cathode pool 262 are used to perform electrophoresis on the sample liquid in the capillary 251. The capillary 251 is located between the transmission optical fiber 161 and the receiving optical fiber 22. The receiving optical fiber 22 is electrically connected to the photoelectric sensor 23.

[0043] The number of transmission fibers 161, receiving fibers 22, and photosensors 23 is equal. The number of transmission fibers 161 exceeds the number of capillaries 251 by one. One transmission fiber serves as a reference fiber to eliminate detection errors caused by environmental interference. The remaining transmission fibers are assigned to capillaries one-to-one. Specifically, in this embodiment, the number of transmission fibers 161, receiving fibers 22, and photosensors 23 is nine, while the number of capillaries 251 is eight, meaning that the number of capillary tube assemblies 25 is eight. The nine transmission fibers 161 are collectively restrained and fixed within a fiber-securing silicone sleeve 162 to receive the coupled light beam.

[0044] The light emitted by the laser light source 141 is irradiated onto the transmission surface of the dichroic mirror 131. After being transmitted through the dichroic mirror 131, the light is focused by the second focusing convex lens 151 onto the transmission optical fiber 161. After passing through the capillary 251, the light is transmitted to the photoelectric sensor 23 through the receiving optical fiber 22. The photoelectric sensor 23 converts the optical signal into an electrical signal and outputs detection information.

[0045] Alternatively, the light emitted by the ultraviolet light source 121 is converged into an integrated light beam by the first focusing convex lens 122, and then irradiated onto the reflecting surface of the dichroic mirror 131. After being reflected by the dichroic mirror 131, the light is focused onto the transmission optical fiber 161 through the second focusing convex lens 151. After passing through the capillary 251, the light is transmitted to the photoelectric sensor 23 through the receiving optical fiber 22. The photoelectric sensor 23 converts the optical signal into an electrical signal and outputs the detection information. In this way, the detection output of multiple substances with different absorption peaks (for example, proteins) can be achieved.

[0046] In this embodiment, the photoelectric sensors 23 are S12698 silicon photodiodes, which have high sensitivity and fast response. 9 photoelectric sensors 23 are installed in the photoelectric sensor box 231.

[0047] Specifically, the core detection module 20 further includes a cooling upper cover 27 , an optical fiber side end cover 281 , a non-optical fiber side end cover 282 , and a board cover 29 .

[0048] The cooling upper cover 27 is installed on the capillary base plate 21, and the optical fiber lower guide plate 24 and the capillary assembly 25 are located in the cooling upper cover 27. The cooling upper cover 27 is made of heat-conductive material, and the inner surface is arc-shaped and covers the capillary 251, and is in direct contact with the capillary 251, so as to maintain the temperature stability of the capillary 251 during detection.

[0049] The optical fiber side end cover 281 and the non-optical fiber side end cover 282 are installed on both sides of the capillary base plate 21. The bottom of the optical fiber side end cover 281 is provided with a notch 2811 for the transmission optical fiber 161 to pass through. The plate cover 29 is installed on the optical fiber lower guide plate 24 for fixing the transmission optical fiber 161 in the slot 241.

[0050] In this embodiment, the capillary 251 is semicircular, and the slot 241 is L-shaped.

[0051] The capillary assembly 25 also includes a capillary groove plate 252, a capillary flat plate 253 and a fixing assembly 254. The capillary groove plate 252 and the capillary flat plate 253 are both semicircular. The capillary 251 is located between the capillary groove plate 252 and the capillary flat plate 253, and the capillary 251 is embedded and fixed in the groove of the capillary groove plate 252. The capillary 251 is fixed by the capillary groove plate 252 and the capillary flat plate 253.

[0052] A fixing assembly 254 is installed at each end of the capillary groove plate 252, and the two ends of the capillary 251 are respectively located in the fixing assembly 254 at both ends. The fixing assembly 254 is the core component for realizing detection, and is used to connect the transmission optical fiber 161, the capillary 251 and the receiving optical fiber 22.

[0053] Specifically, the fixing assembly 254 includes a first optical fiber fixing seat 2541, a second optical fiber fixing seat 2542, a first capillary fixing piece 2543, and a second capillary fixing piece 2544. The first optical fiber fixing seat 2541 and the second optical fiber fixing seat 2542 are fixed together, and the two can be connected by bolts. The first optical fiber fixing seat 2541 and the second optical fiber fixing seat 2542 are provided with optical fiber holes 2545 inside, and the optical fiber holes 2545 intersect the capillary 251 in a cross. The first capillary fixing piece 2543 is installed in the first optical fiber fixing seat 2541, and the second capillary fixing piece 2544 is installed in the second optical fiber fixing seat 2542. The first capillary fixing piece 2543 and the second capillary fixing piece 2544 can be embedded in the fixing assembly 254 by gluing.

[0054] The first capillary fixing piece 2543 and the second capillary fixing piece 2544 divide the optical fiber hole 2545 into a transmission optical fiber hole and a receiving optical fiber hole. The transmission optical fiber hole is used to accommodate the transmission optical fiber 161, and the receiving optical fiber hole is used to accommodate the receiving optical fiber 22.

[0055] In this embodiment, the first capillary fixing piece 2543 and the second capillary fixing piece 2544 are used to clamp the capillary 251 , control the position of the capillary 251 , and prevent the capillary 251 from being misaligned with the transmission optical fiber 161 and the receiving optical fiber 22 .

[0056] In the prior art, alignment of the capillary tube with the transmission optical fiber and the receiving optical fiber typically requires custom capillaries, which is costly. In this embodiment, the first capillary tube fixing piece 2543 and the second capillary tube fixing piece 2544 in the fixing assembly 254 clamp the capillary tube 251, thereby controlling the position of the capillary tube 251 and ensuring alignment of the capillary tube 251 with the transmission optical fiber 161 and the receiving optical fiber 22. This eliminates the need for custom capillaries and reduces costs.

[0057] In addition, in this embodiment, the core detection module 20 also includes a first fiber-pressing base plate 201 and a second fiber-pressing base plate 202. The first fiber-pressing base plate 201 and the second fiber-pressing base plate 202 are located on either side of the fixed assembly 254. The first fiber-pressing base plate 201 and the second fiber-pressing base plate 202 are provided with fiber optic grooves. The fiber optic grooves on the first fiber-pressing base plate 201 are used to accommodate the transmission optical fiber 161, and the fiber optic grooves on the second fiber-pressing base plate 202 are used to accommodate the receiving optical fiber 22, further ensuring that the capillary 251 is aligned with the transmission optical fiber 161 and the receiving optical fiber 22.

[0058] In this embodiment, the fixing assembly 254 further includes a mounting base 2546, which is mounted on the capillary base plate 21. The mounting base 2546 is disposed corresponding to the anode cell 261 or the cathode cell 262. The first optical fiber fixing seat 2541 and the second optical fiber fixing seat 2542 are mounted on the mounting base 2546. A sealing ring 2547 is provided on the outer periphery of the mounting base 2546. The sealing ring 2547 forms a seal with the anode cell 261 or the cathode cell 262 to prevent leakage of the sample liquid.

[0059] In summary, according to the capillary electrophoresis instrument provided by the present invention, since a laser light source 141, an ultraviolet light source 121 and a dichroic mirror 131 are provided, the light emitted by the laser light source 141 is irradiated onto the transmission surface of the dichroic mirror 131, and after being transmitted by the dichroic mirror 131, it is focused onto the transmission optical fiber 161 through the second focusing convex lens 151, or the light emitted by the ultraviolet light source 121 is converged into an integrated light beam by the second focusing convex lens 151, and then irradiated onto the reflection surface of the dichroic mirror 131, and after being reflected by the dichroic mirror 131, it is focused onto the transmission optical fiber 161 through the second focusing convex lens 151, and then the light passes through the capillary 251 and is transmitted to the photoelectric sensor 23 through the receiving optical fiber 22. When in use, it is only necessary to select the corresponding light source according to needs, and the detection of multiple substances with different absorption peaks can be achieved through one device without replacing accessories, which is lower in cost and easier to operate. In addition, the present invention adopts multiple photoelectric sensors, and one optical fiber can be connected to one photoelectric sensor. The photoelectric sensor realizes detection based on the optical path signal, which can effectively improve the detection sensitivity.

[0060] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "examples," "specific examples," or "some examples" means that a specific feature, structure, material, or characteristic described in conjunction with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0061] The above-described embodiments merely illustrate several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art would be able to make various modifications and improvements without departing from the spirit of the present invention, and these modifications and improvements fall within the scope of the present invention. Therefore, the scope of the present invention shall be determined by the appended claims.

Claims

1. A capillary electrophoresis instrument, characterized in that: It includes an optical path module and a core detection module; the optical path module includes an optical path base plate, and an ultraviolet light source assembly, a dichroic mirror assembly, a laser light source assembly, a focusing lens assembly and a transmission optical fiber assembly installed on the optical path base plate; The ultraviolet light source assembly includes an ultraviolet light source and a first focusing convex lens, wherein the first focusing convex lens is installed on the output light path of the ultraviolet light source; the dichroic mirror assembly includes a dichroic mirror; the laser light source assembly includes a laser light source; the focusing lens assembly includes a second focusing convex lens, and the transmission fiber assembly includes a plurality of transmission fibers; the dichroic mirror is fixed to the optical path base plate at a preset angle; the reflective surface of the dichroic mirror faces the ultraviolet light source, and the transmissive surface of the dichroic mirror faces the laser light source; The core detection module includes a capillary base plate, a plurality of photoelectric sensors and a plurality of receiving optical fibers. The capillary base plate is provided with an optical fiber lower guide plate and a plurality of capillary tube assemblies. The bottom of the capillary base plate is provided with an anode pool and a cathode pool. The optical fiber lower guide plate is provided with a plurality of slots for placing transmission optical fibers. Each capillary tube assembly includes a capillary tube, one end of the capillary tube is inserted into the anode pool, and the other end is inserted into the cathode pool. The capillary tube is located between the transmission optical fiber and the receiving optical fiber, and the receiving optical fiber is electrically connected to the photoelectric sensor. The light emitted by the laser light source is irradiated onto the transmission surface of the dichroic mirror, and after being transmitted through the dichroic mirror, is focused onto the transmission optical fiber by the second focusing convex lens. After passing through the capillary tube, the light is transmitted to the photoelectric sensor through the receiving optical fiber. Alternatively, the light emitted by the ultraviolet light source is converged into an integrated beam by the first focusing convex lens, irradiated onto the reflective surface of the dichroic mirror, reflected by the dichroic mirror, and focused onto the transmission optical fiber by the second focusing convex lens. After passing through the capillary, the light is transmitted to the photoelectric sensor through the receiving optical fiber. The capillary is semicircular, and the slot is L-shaped; the capillary assembly further includes a capillary groove plate, a capillary flat plate, and a fixing assembly, wherein the capillary groove plate and the capillary flat plate are both semicircular, the capillary is located between the capillary groove plate and the capillary flat plate, and the capillary is embedded and fixed in the groove of the capillary groove plate, the fixing assemblies are respectively installed at both ends of the capillary groove plate, and the two ends of the capillary are respectively located in the fixing assemblies at both ends; The fixing assembly includes a first optical fiber fixing seat, a second optical fiber fixing seat, a first capillary fixing plate, and a second capillary fixing plate. The first optical fiber fixing seat and the second optical fiber fixing seat are fixed together, and optical fiber holes are provided inside the first optical fiber fixing seat and the second optical fiber fixing seat. The optical fiber holes and the capillary tubes intersect crosswise. The first capillary tube fixing plate is installed in the first optical fiber fixing seat, and the second capillary tube fixing plate is installed in the second optical fiber fixing seat. The first capillary tube fixing plate and the second capillary tube fixing plate are used to clamp the capillary tube. The first capillary tube fixing plate and the second capillary tube fixing plate divide the optical fiber hole into a transmission optical fiber hole and a receiving optical fiber hole. The transmission optical fiber hole is used to accommodate a transmission optical fiber, and the receiving optical fiber hole is used to accommodate a receiving optical fiber.

2. The capillary electrophoresis instrument according to claim 1, characterized in that The ultraviolet light source assembly also includes an ultraviolet outer sleeve, an ultraviolet adjustment sleeve, a ultraviolet adjustment fixed block, a slider, and a slide rail. The ultraviolet light source is installed in the ultraviolet outer sleeve, and the ultraviolet outer sleeve is installed in the ultraviolet adjustment sleeve. The ultraviolet adjustment sleeve is installed in the through hole on the ultraviolet adjustment fixed block through an adjusting bolt. The ultraviolet adjustment fixed block is fixed to the slider, and the slider is installed on the slide rail. The slide rail is fixed on the optical path base plate, and the slider can slide on the slide rail.

3. The capillary electrophoresis instrument according to claim 2, characterized in that: The dichroic mirror assembly further comprises a dichroic mirror fixing block, the dichroic mirror is mounted on the dichroic mirror fixing block, and the dichroic mirror fixing block is mounted on the optical path bottom plate; The laser light source assembly further includes a laser adjustment sleeve and a laser adjustment fixing block, wherein the laser light source is mounted in the laser adjustment sleeve, the laser adjustment sleeve is mounted on the laser adjustment fixing block via an adjustment bolt, and the laser adjustment fixing block is fixed to the optical path base plate; The focusing lens assembly further includes a focusing lens fixing block, the second focusing convex lens is mounted in the focusing lens fixing block, and the focusing lens fixing block is fixed to the optical path bottom plate; The transmission optical fiber assembly also includes an optical fiber fixing silicone sleeve and a transmission optical fiber fixing block. The transmission optical fiber is installed in the optical fiber fixing silicone sleeve, the optical fiber fixing silicone sleeve is installed on the transmission optical fiber fixing block, and the transmission optical fiber fixing block is fixed on the optical path base plate.

4. The capillary electrophoresis instrument according to claim 1, characterized in that The core detection module also includes a cooling cover, an optical fiber side end cover, a non-optical fiber side end cover, and a plate cover; The cooling upper cover is installed on the capillary base plate, the optical fiber lower guide plate and the capillary assembly are located inside the cooling upper cover, the optical fiber side end cover and the non-optical fiber side end cover are installed on both sides of the capillary base plate, the bottom of the optical fiber side end cover is provided with a notch for transmitting the optical fiber through, and the plate cover is installed on the optical fiber lower guide plate.

5. The capillary electrophoresis instrument according to claim 1, characterized in that: The fixing assembly also includes a mounting base, which is mounted on the capillary base plate. The mounting base is arranged corresponding to the anode pool or the cathode pool. The first optical fiber fixing seat and the second optical fiber fixing seat are mounted on the mounting base. A sealing ring is provided on the outer periphery of the mounting base.

6. The capillary electrophoresis instrument according to claim 5, characterized in that: The core detection module also includes a first fiber pressing base plate and a second fiber pressing base plate, the first fiber pressing base plate and the second fiber pressing base plate are located on both sides of the fixed component, and the first fiber pressing base plate and the second fiber pressing base plate are provided with fiber grooves.

7. The capillary electrophoresis instrument according to claim 1, characterized in that: The number of the transmission optical fibers and the receiving optical fibers, as well as the number of the photoelectric sensors, is equal. The number of the transmission optical fibers is one more than the number of the capillaries. One of the transmission optical fibers is used as a reference optical fiber, and the remaining transmission optical fibers are respectively arranged in one-to-one correspondence with the capillaries.

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