Molecular interaction analyzer with liquid level monitoring function

Abstract

The invention discloses a molecular interaction analyzer with a liquid level monitoring function. Relates to the technical field of molecular interaction analyzers. The analysis assembly comprises a detector, a signal processor and a display screen; the reagent conveying assembly comprises a base, a placement frame, reagent bottles and a distribution pump, the base is connected with the side wall of the box body, a plurality of placement grooves are formed in the placement frame, the reagent bottles are placed in the placement grooves, the distribution pump is connected with the detector through a sample feeding hose, and the reagent bottles are connected with the distribution pump through a sampling hose; the liquid level monitoring assembly comprises a capacitive sensor and an electrode, the capacitive sensor is electrically connected with the signal processor, the electrode is connected with the capacitive sensor through an electric wire, an adhesion layer is arranged on the electrode, and the electrode is tightly attached to the side wall of the reagent bottle. By arranging the liquid level monitoring assembly, accurate measurement of a reagent can be ensured, overflow or insufficiency is prevented, and therefore the monitoring reliability and the automation degree are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of molecular interaction analyzers, and more particularly to a molecular interaction analyzer with liquid level monitoring. Background Art

[0002] A molecular interaction analyzer is a device used to study the interactions between biomolecules and is widely used in fields such as biochemistry, molecular biology, and drug research and development.

[0003] Integrating a liquid level monitoring function in a molecular detector is mainly used to ensure the accurate measurement of samples or reagents, prevent overflow or shortage, thereby improving the reliability and automation of monitoring.

[0004] Currently, the existing problems of the existing molecular interaction analyzers in liquid level monitoring are as follows:

[0005] Due to different types of liquids to be measured, affected by transparency, viscosity, etc., the monitoring accuracy of the sensor is insufficient, and the liquid level monitoring is inaccurate, which may affect the accuracy of the analysis and further affect the experimental results;

[0006] There are environmental interferences, such as temperature changes or vibrations, which affect the performance of the sensor;

[0007] The existing molecular interaction analyzers do not have the function of giving a prompt or alarm after presetting the liquid level value.

[0008] Therefore, how to provide a molecular interaction analyzer with liquid level monitoring that has higher liquid level monitoring accuracy, can adjust the temperature, and has an alarm prompt function is an urgent problem to be solved by those skilled in the art. Summary of the Invention

[0009] In view of this, the present invention provides a molecular interaction analyzer with liquid level monitoring, aiming to solve one of the problems in the above background art, with higher liquid level monitoring accuracy, the ability to adjust the temperature, and an alarm prompt function.

[0010] To achieve the above object, the present invention adopts the following technical solutions:

[0011] A molecular interaction analyzer with liquid level monitoring, comprising:

[0012] A box body, the side wall of the box body is provided with a transparent protective cover, and the transparent protective cover is hinged to the side wall of the box body;

[0013] An analysis component, the analysis component includes a detector, a signal processor and a display screen. The detector and the signal processor are both arranged in the box body, the display screen is arranged on the side wall of the box body, and the detector and the display screen are both signal-connected to the signal processor;

[0014] The reagent delivery assembly includes a base, a placement rack, reagent bottles, and a dispensing pump. The base is connected to the side wall of the box body. The placement rack is arranged above the base. There are several placement slots on the placement rack. The reagent bottles are placed in the placement slots. The dispensing pump is arranged in the box body. The dispensing pump is connected to the detector through a sample delivery hose. The reagent bottles are connected to the dispensing pump through a sampling hose.

[0015] The liquid level monitoring assembly includes a capacitance sensor and an electrode. The capacitance sensor is arranged on the side wall of the box body and is close to the placement rack. The capacitance sensor is electrically connected to the signal processor. The electrode is connected to the capacitance sensor through a wire. An adhesion layer is provided on the electrode, and the electrode is closely attached to the side wall of the reagent bottle.

[0016] Further, the electrode is arranged at one end of the sampling hose close to the reagent bottle. The electrode is signal-connected to the capacitance sensor, and the electrode extends into the reagent bottle following the sampling hose.

[0017] Further, the liquid level monitoring assembly includes a laser emitter and a receiver. The laser emitter and the receiver are arranged on the side wall of the box body close to the reagent bottle. Both the laser emitter and the receiver face the reagent bottle. The laser emitter and the receiver are connected to the side wall of the box body through slide rails.

[0018] Further, the liquid level monitoring assembly includes a gravity sensor. The gravity sensor is arranged at the bottom of the placement slot, contacts the bottom of the reagent bottle, and is signal-connected to the signal processor.

[0019] Further, it further includes a sealed protective shell. The sealed protective shell is hinged to the side wall of the box body. The sealed protective shell is made of a transparent material. An elastic sealing layer is provided on the side wall of the sealed protective shell that contacts the box body and the placement rack. The sealed protective shell and the box body cooperate to provide a sealed environment above the placement rack.

[0020] Further, it further includes a temperature controller. The temperature controller is arranged on the sealed protective shell.

[0021] Further, the reagent delivery assembly further includes a waste liquid collection mechanism. The waste liquid collection mechanism includes a liquid storage box and a waste liquid pump. The liquid storage box is arranged in the base. One end of the waste liquid pump is communicated with the liquid storage box through a waste liquid hose, and the other end of the waste liquid pump is communicated with the detector through a waste liquid hose.

[0022] Further, it further includes a warning indicator light, which is arranged on the box body and is in signal connection with the signal processor.

[0023] Further, a shock-absorbing layer is provided between the placement rack and the base.

[0024] As can be seen from the above technical solutions, compared with the prior art, the present invention discloses a molecular interaction analyzer with liquid level monitoring. By setting an analysis component, the molecular structure of substances can be detected and analyzed; by setting a reagent delivery component, automatic extraction and discharge of reagents can be achieved, which is convenient to operate, and multiple reagent bottles can be analyzed at one time, with higher efficiency; by setting a liquid level monitoring component, the liquid level is measured by using the capacitance change between the reagent and the electrode. When the reagent liquid level changes, the capacitance between the reagent and the electrode will change. By measuring the capacitance value between the electrodes with a capacitance sensor, the height of the liquid level can be determined. When the liquid level reaches the preset value, an alarm is sent to the experimenter to avoid liquid overflow from contaminating the instrument or the sampling hose sucking air, resulting in detection failure, which can significantly improve the detection stability and automation level of the molecular interaction analyzer, while reducing sample consumption, saving costs, and improving the accuracy and authenticity of analysis. Description of the Drawings

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the following drawings are only the embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained according to the provided drawings.

[0026] Figure 1 It is a schematic structural diagram of the molecular interaction analyzer with liquid level monitoring provided by the present invention;

[0027] Figure 2 It is a schematic structural diagram of the molecular interaction analyzer with liquid level monitoring provided by the present invention (the electrode is arranged on the side wall of the reagent bottle);

[0028] Figure 3 It is a schematic structural diagram of the molecular interaction analyzer with liquid level monitoring provided by the present invention (the electrode is arranged on the sampling hose);

[0029] Figure 4 It is a schematic structural diagram of the molecular interaction analyzer with liquid level monitoring provided by the present invention (a laser emitter and a receiver are provided);

[0030] Figure 5 It is a schematic structural diagram of the reagent delivery component provided by the present invention;

[0031] Figure 6 Schematic internal structure diagram of the placement groove provided with a gravity sensor according to the present invention;

[0032] Figure 7 Schematic structure diagram of the detachably provided liquid level monitoring component according to the present invention (electrodes are arranged on the side wall of the reagent bottle);

[0033] Figure 8 Schematic structure diagram of the detachably provided liquid level monitoring component according to the present invention (electrodes are arranged on the sampling hose);

[0034] Figure 9 Schematic structure diagram of the detachably provided liquid level monitoring component according to the present invention (a gravity sensor is provided).

[0035] Wherein: 1 is a box body; 2 is a transparent protective cover; 3 is a display screen; 4 is a base; 5 is a placement rack; 6 is a reagent bottle; 7 is a dispensing pump; 8 is a placement groove; 9 is a sample delivery hose; 10 is a sampling hose; 11 is a capacitance sensor; 12 is an electrode; 13 is a laser emitter; 14 is a receiver; 15 is a slide rail; 16 is a gravity sensor; 17 is a sealed protective shell; 18 is a temperature controller; 19 is a liquid storage box; 20 is a waste liquid pump; 21 is a waste liquid hose; 22 is a warning indicator light; 23 is a shock absorption layer; 24 is a mounting plate; 25 is a liquid inlet valve. Specific embodiments

[0036] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0037] See Figures 1-9 , the embodiments of the present invention disclose a molecular interaction analyzer with liquid level monitoring, including:

[0038] A box body 1, on the side wall of the box body 1 there is a transparent protective cover 2, and the transparent protective cover 2 is hinged to the side wall of the box body 1;

[0039] An analysis component, the analysis component includes a detector, a signal processor and a display screen 3, the detector and the signal processor are both arranged in the box body 1, the display screen 3 is arranged on the side wall of the box body 1, and both the detector and the display screen 3 are signal-connected to the signal processor; by providing the analysis component, the molecular structure of substances is detected and analyzed;

[0040] The reagent delivery assembly includes a base 4, a placement rack 5, reagent bottles 6, and a dispensing pump 7. The base 4 is connected to the side wall of the cabinet 1. The placement rack 5 is arranged above the base 4. A number of placement slots 8 are provided on the placement rack 5. The reagent bottles 6 are placed in the placement slots 8. The dispensing pump 7 is arranged inside the cabinet 1. The dispensing pump 7 is connected to the detector through a sample delivery hose 9. The reagent bottles 6 are connected to the dispensing pump 7 through a sampling hose 10. By providing the reagent delivery assembly, automatic extraction and discharge of reagents are achieved, which is convenient to operate. The reagents in multiple reagent bottles 6 can be analyzed at one time, with higher efficiency.

[0041] The liquid level monitoring assembly includes a capacitance sensor 11 and an electrode 12. The capacitance sensor 11 is arranged on the side wall of the cabinet 1 and is close to the placement rack 5. The capacitance sensor 11 is electrically connected to a signal processor. The electrode 12 is connected to the capacitance sensor 11 through a wire. An adhesion layer is provided on the electrode 12. The electrode 12 is closely attached to the side wall of the reagent bottle 6. The liquid level is measured by using the capacitance change between the reagent and the electrode 12. When the liquid level of the reagent changes, the capacitance between the reagent and the electrode 12 will change. By measuring the capacitance value between the electrodes 12 through the capacitance sensor 11, the height of the liquid level can be determined.

[0042] In this embodiment, the electrode 12 is arranged at one end of the sampling hose 10 close to the reagent bottle 6. The electrode 12 is signal-connected to the capacitance sensor 11. The electrode 12 extends into the reagent bottle 6 following the sampling hose 10. The electrode 12 is in direct contact with the reagent, and the covered area or spacing of the electrode 12 is changed by the change in the liquid level of the reagent.

[0043] In this embodiment, the liquid level monitoring assembly includes a laser emitter 13 and a receiver 14. The laser emitter 13 and the receiver 14 are arranged on the side wall of the cabinet 1 close to the reagent bottle 6. Both the laser emitter 13 and the receiver 14 face the reagent bottle 6. The laser emitter 13 and the receiver 14 are connected to the side wall of the cabinet 1 through slide rails 15. The liquid level height is accurately measured by calculating the reflection time difference through the laser emitted by the laser emitter 13 to the reagent surface and received by the receiver 14, and it has a better effect when measuring transparent or low-turbidity liquids.

[0044] In this embodiment, the liquid level monitoring assembly includes a gravity sensor 16. The gravity sensor 16 is arranged at the bottom of the placement slot 8. The gravity sensor 16 is in contact with the bottom of the reagent bottle 6. The gravity sensor 16 is signal-connected to a signal processor. The weight of the reagent bottle 6 is measured through the gravity sensor 16 to judge the liquid volume of the reagent in the reagent bottle 6, and the liquid level monitoring is more direct and real-time.

[0045] In this embodiment, it further includes a sealed protective shell 17. The sealed protective shell 17 is hinged to the side wall of the box body 1. The sealed protective shell 17 is made of a transparent material. An elastic sealing layer is provided on the side walls of the sealed protective shell 17 that contact the box body 1 and the placement rack 5. The sealed protective shell 17 and the box body 1 cooperate to provide a sealed environment above the placement rack 5. At the same time, the sealed protective shell 17 isolates the liquid surface from external interference, and the sealed environment facilitates temperature adjustment.

[0046] In this embodiment, it further includes a temperature controller 18. The temperature controller 18 is arranged on the sealed protective shell 17. The temperature is adjusted through the temperature controller 18 for temperature compensation to avoid density changes caused by the thermal expansion and contraction of the reagent, which may affect the accuracy of liquid level monitoring.

[0047] In this embodiment, the reagent delivery assembly further includes a waste liquid collection mechanism. The waste liquid collection mechanism includes a liquid storage box 19 and a waste liquid pump 20. The liquid storage box 19 is arranged in the base 4. One end of the waste liquid pump 20 is connected to the liquid storage box 19 through a waste liquid hose 21, and the other end of the waste liquid pump 20 is connected to the detector through the waste liquid hose 21, which is convenient for storing the waste liquid after detection.

[0048] In this embodiment, it further includes a warning indicator light 22. The warning indicator light 22 is arranged on the box body 1. The warning indicator light 22 is signal-connected to the signal processor. By setting the warning indicator light 22, when the liquid level reaches the preset value, an alarm prompt is given.

[0049] In this embodiment, a shock-absorbing layer 23 is provided between the placement rack 5 and the base 4 to improve stability, buffer, and avoid the dynamic liquid level from affecting the liquid level monitoring.

[0050] In addition, in this embodiment, a smooth layer is provided on the side wall of the placement groove 8 to avoid affecting the weight measurement of the reagent bottle 6.

[0051] Both the laser emitter 13 and the receiver 14 are arranged on the mounting plate 24. The mounting plate 24 is slidably arranged on the slide rail 15, which is convenient for adjusting the height positions of the laser emitter 13 and the receiver 14.

[0052] A liquid inlet valve 25 is provided at the connection position between the sample delivery hose 9 and the dispensing pump 7, and a liquid inlet valve 25 is also provided at the connection position between the waste liquid hose 21 and the waste liquid pump 20 to improve the accuracy of reagent sampling.

[0053] The placement rack 5 is detachably arranged on the base 4.

[0054] The setting of the shape of the box body 1 in this application includes but is not limited to the shape in the attached drawings of the specification. Figures 1-4 in the drawings.

[0055] Embodiment 2, as Figures 7-9As shown, the reagent bottle 6, the sampling hose 10, and the liquid level monitoring component in the reagent delivery component are all detachably connected to the box body 1. The liquid level monitoring component is set as the gravity sensor 16, such as Figure 7 ;

[0056] The liquid level monitoring component is set as the capacitance sensor 11 and the electrode 12. The electrode 12 is arranged on the side wall of the reagent bottle 6, such as Figure 8 ;

[0057] The electrode 12 is arranged at one end of the sampling hose 10 close to the reagent bottle 6, such as Figure 9 ;

[0058] The liquid level monitoring component is set as the laser emitter 13 and the receiver 14. The laser emitter 13 and the receiver 14 are arranged on the side wall of the box body 1 close to the reagent bottle 6. Both the laser emitter 13 and the receiver 14 face the reagent bottle 6. The laser emitter 13 and the receiver 14 are connected to the side wall of the box body 1 through the slide rail 15. The detachable connection between the laser emitter 13 and the receiver 14 and the side wall of the box body 1 is realized through the slide rail. The laser is emitted by the laser emitter 13 to the reagent surface and received by the receiver 14, and the liquid level height is accurately measured by calculating the reflection time difference, so as to realize the liquid level monitoring of the reagent bottle 6;

[0059] A sealing protection shell 17 is provided to cooperate with the reagent bottle 6, the sampling hose 10, and the liquid level monitoring component. The sealing protection shell 17 and the box body 1 cooperate to provide a sealed environment for liquid extraction and liquid level monitoring; at the same time, the sealing protection shell 17 isolates the liquid level from the outside interference, and the sealed environment is convenient for temperature adjustment through the temperature controller 18.

[0060] Multiple reagent bottles 6 are provided, and the multiple reagent bottles 6 are respectively set as a waste liquid bottle, a water bottle, and several buffer solution bottles.

[0061] In this specification, each embodiment is described in a progressive manner. The key point of each embodiment is to illustrate the differences from other embodiments. The same or similar parts among the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the description of the method part.

[0062] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to these embodiments shown herein, but will be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A molecular interaction analyzer with liquid level monitoring, characterized in that, Comprising: A box body, on the side wall of which is provided a transparent protective cover, and the transparent protective cover is hinged to the side wall of the box body; An analysis component, which includes a detector, a signal processor, and a display screen. The detector and the signal processor are both arranged inside the box body, the display screen is arranged on the side wall of the box body, and both the detector and the display screen are signal-connected to the signal processor; A reagent delivery component, including a base, a placement rack, reagent bottles, and a dispensing pump. The base is connected to the side wall of the box body, the placement rack is arranged above the base, several placement slots are provided on the placement rack, the reagent bottles are placed in the placement slots, the dispensing pump is arranged inside the box body, the dispensing pump is connected to the detector through a sample delivery hose, and the reagent bottles are connected to the dispensing pump through a sampling hose; A liquid level monitoring component, including a capacitance sensor and an electrode. The capacitance sensor is arranged on the side wall of the box body and is close to the placement rack, the capacitance sensor is electrically connected to the signal processor, the electrode is connected to the capacitance sensor through a wire, and an adhesion layer is provided on the electrode, and the electrode is closely attached to the side wall of the reagent bottle.

2. The molecular interaction analyzer with liquid level monitoring according to claim 1, wherein The electrode is arranged at one end of the sampling hose close to the reagent bottle, the electrode is signal-connected to the capacitance sensor, and the electrode extends into the reagent bottle following the sampling hose.

3. The molecular interaction analyzer with liquid level monitoring according to claim 1, wherein The liquid level monitoring component includes a laser emitter and a receiver. The laser emitter and the receiver are arranged on the side wall of the box body close to the reagent bottle, both the laser emitter and the receiver face the reagent bottle, and the laser emitter and the receiver are connected to the side wall of the box body through slide rails.

4. A molecular interaction analyzer with liquid level monitoring according to claim 1, characterized in that, The liquid level monitoring component includes a gravity sensor. The gravity sensor is arranged at the bottom of the placement slot, the gravity sensor contacts the bottom of the reagent bottle, and the gravity sensor is signal-connected to the signal processor.

5. The molecular interaction analyzer with liquid level monitoring according to claim 1, characterized in that, It further includes a sealed protective shell, which is hinged to the side wall of the box body. The sealed protective shell is made of a transparent material, and an elastic sealing layer is provided on the side wall of the sealed protective shell that contacts the box body and the placement rack. The sealed protective shell and the box body cooperate to provide a sealed environment above the placement rack.

6. The molecular interaction analyzer with liquid level monitoring according to claim 5, characterized in that, It further includes a temperature controller, which is arranged on the sealed protective shell.

7. The molecular interaction analyzer with liquid level monitoring according to claim 1, wherein, The reagent delivery component further includes a waste liquid collection mechanism, which includes a liquid storage box and a waste liquid pump. The liquid storage box is arranged inside the base, one end of the waste liquid pump is communicated with the liquid storage box through a waste liquid hose, and the other end of the waste liquid pump is communicated with the detector through a waste liquid hose.

8. A molecular interaction analyzer with liquid level monitoring according to claim 1, characterized in that, It further includes a warning indicator light, which is arranged on the box body, and the warning indicator light is signal-connected to the signal processor.

9. The molecular interaction analyzer with liquid level monitoring according to claim 2, characterized in that, A shock-absorbing layer is provided between the placement rack and the base.

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