Egg holding needle for biopsy

Abstract

The invention discloses an egg holding needle for biopsy, and particularly relates to the technical field of medical instruments, the egg holding end of the egg holding needle is a cylindrical needle body, a hollow cavity extending axially is formed in the needle body, a holding hole communicated with the hollow cavity is formed in the holding end face of the needle body, and the holding hole is communicated with the hollow cavity. The axial outer wall of the needle body is provided with an inclined flat slope intersecting with the holding end, and three sunken tooth grooves are distributed in the flat slope to form a gradient cutting sawtooth structure. According to the egg holding needle for biopsy, the flat gradient with the inclination angle of 25 degrees is designed at the front end of the needle tip, the three parallel tooth grooves are formed in the gradient surface to form a miniature sawtooth structure, and through a layer-by-layer progressive cutting mechanism, it is ensured that an embryo and biopsy tissue can be thoroughly separated through one-time operation; the problems that traditional mechanical cutting is easy to slip and incomplete and the thermal damage risk of traditional laser is solved; the 25-degree flat slope surface of the needle point of the egg holding needle is combined with the arc-shaped end face design, so that the cutting stability is improved, and the slipping phenomenon is reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly relates to an egg holding needle for biopsy. Background Art

[0002] During embryo biopsy, a small amount of cells need to be separated and collected from within the zona pellucida of the embryo for genetic testing. Traditional methods rely on laser cutting technology, but have the following drawbacks: the risk of thermal damage, where the laser may cause thermal damage to the embryo tissue, affecting subsequent developmental potential. To address the above problems, the prior art has switched to using a mechanical egg holding needle for separation. However, the tip of the traditional egg holding needle has a smooth arc-shaped structure (as shown in Figure 2 ), and has the following problems: it is prone to slipping during cutting, resulting in incomplete tissue cutting; when the cutting force is insufficient, the entire embryo may be dragged out of the zona pellucida, causing embryo damage. Therefore, there is an urgent need for an egg holding needle with an improved structure to achieve safe and efficient embryo biopsy. Summary of the Invention

[0003] The present invention provides an egg holding needle for biopsy, which solves the problems of incomplete cutting, easy slipping, and embryo damage in the prior art by optimizing the design of the tip structure of the egg holding needle, and at the same time avoids the use of lasers, improving the success rate and safety of biopsy.

[0004] To achieve the above object, the technical solution adopted by the present invention is as follows:

[0005] An egg holding needle for biopsy, the egg holding end of which is a cylindrical needle body. A hollow cavity extending axially is provided inside the needle body. A suction hole communicating with the hollow cavity is provided on the suction end face of the needle body. An inclined flat slope surface intersecting with the suction end is formed on the outer wall of the axial direction of the needle body. Three concave tooth grooves are arranged in parallel on the flat slope surface, forming a gradient cutting serrated structure. The suction end of the needle body is a smooth arc-shaped end face, which avoids scratching the embryo or the inner wall of the instrument during operation, and the arc section is seamlessly connected with the serrated section to ensure cutting stability.

[0006] Preferably, the depths of the tooth grooves are 10 microns, 15 microns, and 20 microns in sequence. The depths of the three tooth grooves increase gradually. The first tooth groove is used for initial cutting, and the subsequent tooth grooves gradually deepen the cutting to ensure that the embryo and the biopsy tissue can be completely separated in one operation.

[0007] Preferably, the angle between the flat slope surface and the axial direction of the needle body is 25 degrees.

[0008] Preferably, the inner diameter of the needle body is 30 microns, and the outer diameter of the needle body is 120 microns.

[0009] Preferably, the needle body is made of high-precision borosilicate glass material, which has transparency, supports real-time microscopic observation of the needle body interface, and improves the visibility of operation; at the same time, it meets the requirements of the embryo environment and avoids the risk of metal ion release. Borosilicate glass has high strength and corrosion resistance, and can meet the processing requirements of small sizes (inner diameter 30 microns, outer diameter 120 microns).

[0010] Preferably, the surface of the egg-holding end of the needle body is coated with a nanoscale diamond-like carbon coating, which reduces the friction coefficient during cutting and can be reduced to less than 0.1, reducing tissue adhesion and mechanical damage.

[0011] Preferably, honeycomb-shaped pits are laser engraved on the surface of the needle body to simulate the microscopic texture of the insect mouthpart, further reducing the tissue contact area and reducing the adhesion resistance.

[0012] Compared with the prior art, the present invention has the following beneficial effects:

[0013] The present invention discloses an egg-holding needle for biopsy. A flat slope with an inclination angle of 25° is designed at the front end of the needle tip. Three parallel tooth grooves are arranged on the slope surface to form a micro-serrated structure. Through a layer-by-layer progressive cutting mechanism, it is ensured that the embryo and the biopsy tissue can be completely separated in one operation, solving the problems of easy slipping and incompleteness of traditional mechanical cutting and the risk of thermal damage of traditional lasers; the 25° flat slope surface of the needle tip of the egg-holding needle is combined with the arc-shaped end face design, which increases the cutting stability and reduces the slipping phenomenon. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 is a schematic diagram of the overall structure of the present invention;

[0015] Figure 2 is a schematic diagram of the needle tip structure of the egg-holding needle of the prior art.

[0016] In the figure: 100, needle body; 101, flat slope surface; 102, tooth groove; 103, arc-shaped end face; 104, hollow cavity. DETAILED DESCRIPTION OF THE INVENTION

[0017] In order to make the technical means, creative features, achieved purposes and functions of the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

[0018] Such as Figure 1As shown in the figure, an egg-holding needle for biopsy has a cylindrical needle body 100 at its egg-holding end. There is a hollow cavity 104 extending axially inside the needle body 100. A suction hole 200 communicating with the hollow cavity 104 is provided on the suction end face of the needle body 100. Specifically, an inclined flat slope 101 intersecting with the suction end is formed on the outer wall of the axial direction of the needle body 100. Three concave tooth grooves 102 are arranged in parallel on the flat slope 101. The flat slope 101 and the tooth grooves 102 are formed by chemical etching combined with a polishing process to ensure a smooth cutting edge and avoid embryo damage. The depths of the three tooth grooves 102 increase in a gradient, forming a gradient cutting serrated structure. The first tooth groove 102 is used for preliminary cutting, and the subsequent tooth grooves 102 gradually deepen the cutting to ensure that the embryo and the biopsy tissue can be completely separated in one operation. The suction end of the needle body 100 is a smooth arc-shaped end face 103 to avoid scratching the embryo or the inner wall of the instrument during the operation. The depths of the tooth grooves 102 are 10 microns, 15 microns, and 20 microns in sequence. The angle between the flat slope 101 and the axial direction of the needle body 100 is 25 degrees. The inner diameter of the needle body 100 is 30 microns, and the outer diameter of the needle body 100 is 120 microns.

[0019] The needle body 100 is made of high-precision borosilicate glass material, which has transparency, supports real-time microscopic observation of the needle body interface, improves the visibility of the operation, and at the same time meets the requirements of the embryo environment and avoids the risk of metal ion release. Borosilicate glass has high strength and corrosion resistance characteristics, can meet the needs of micro-size processing (inner diameter 30 microns, outer diameter 120 microns). At the same time, the egg-holding end surface of the needle body 100 is coated with a nanoscale diamond-like carbon coating to further reduce the friction coefficient and reduce tissue adhesion and mechanical damage during the cutting process. Honeycomb-shaped pits are also laser engraved on the surface of the needle body 100 to further reduce the tissue contact area and reduce the adhesion resistance.

[0020] The present invention realizes step-by-step cutting through the gradient cutting serrated structure to ensure that the embryo and the biopsy tissue can be completely separated in one operation, and the cutting success rate is increased to more than 95%, avoiding the risk of thermal damage of traditional lasers; at the same time, the 25° flat slope of the needle tip combined with the arc-shaped end face design increases the cutting stability and reduces the slipping phenomenon; the needle body is made of high-precision borosilicate glass material, which has transparency, supports real-time microscopic observation of the needle body interface, and improves the visibility of the operation; and the surface of the needle body is coated with a nanoscale diamond-like carbon coating to reduce tissue adhesion and mechanical damage during cutting; honeycomb-shaped pits are laser engraved on the surface of the needle body to simulate the microscopic texture of the insect mouthpart, reduce the tissue contact area, and reduce the cutting resistance by 30%, significantly improving the operational fluency.

[0021] The foregoing has shown and described the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments, and what is described in the above embodiments and the specification is only to illustrate the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will also have various changes and improvements, and these changes and improvements fall within the scope of the present invention claimed. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.

Claims

1. An egg-holding needle for biopsy, the egg-holding end of which is a cylindrical needle body (100). A hollow cavity (104) extending axially is provided inside the needle body (100). A suction hole (200) communicating with the hollow cavity (104) is provided on the suction end surface of the needle body (100), and it is characterized in that: An inclined flat slope surface (101) intersecting with the suction end is provided on the axial outer wall of the needle body (100). Three concave tooth grooves (102) are arranged in parallel on the flat slope surface (101) to form a gradient cutting sawtooth structure. The suction end of the needle body (100) is a smooth arc-shaped end face (103).

2. The egg holding needle for biopsy according to claim 1, wherein: The depths of the three tooth grooves (102) increase in a gradient. The first tooth groove (102) is used for initial cutting, and the subsequent tooth grooves (102) gradually deepen the cutting to ensure that the embryo and the biopsy tissue can be completely separated in one operation.

3. A holding needle for biopsy according to claim 1, characterized in that: The depths of the tooth grooves (102) are 10 microns, 15 microns, and 20 microns in sequence.

4. A holding needle for biopsy according to claim 1, characterized in that: The included angle between the flat slope surface (101) and the axis of the needle body (100) is 25 degrees.

5. A holding needle for biopsy according to claim 1, characterized in that: The inner diameter of the needle body (100) is 30 microns, and the outer diameter of the needle body (100) is 120 microns.

6. The egg holding needle for biopsy according to claim 1, characterized in that: The needle body (100) is made of high-precision borosilicate glass material.

7. A holding needle for biopsy according to claim 1, characterized in that: The surface of the egg-holding end of the needle body (100) is coated with a nanoscale diamond-like carbon coating.

8. A holding egg needle for biopsy according to claim 1, characterized in that: Honeycomb-shaped pits are laser engraved on the surface of the needle body (100) to reduce the tissue contact area and the adhesion resistance.

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