Chinese redbud foot bath powder

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to Chinese redbud foot bath powder which comprises 15-30 parts of Chinese redbud, 10-20 parts of folium artemisiae argyi, 8-15 parts of safflower, 5-12 parts of angelica sinensis, 5-10 parts of salvia miltiorrhiza, 3-8 parts of lavender, 3-8 parts of ligusticum wallichii and 1-3 parts of borneol. The Chinese redbud is fresh buds, and the harvesting time is 5-7 days before the full-bloom stage. The auxiliary materials comprise 2-5 parts of sodium bicarbonate and 0.5-1.5 parts of lauryl sodium sulfate. The traditional Chinese medicine composition has the following beneficial effects: synergistic interaction is realized: the Chinese redbud flavone and the safflower quinone component form a compound, and the in-vitro transdermal absorption rate is increased to 68.5 + / -3.2%; the instant characteristic is that the lauryl sodium sulfate enables the product to be completely dissolved in 30 seconds, and the dissolving time is shortened by 70% compared with that of a traditional product; the safety is as follows: a skin irritation test (GB / T 16886.10) proves that no irritation reaction exists.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, and specifically to a Chinese redbud flower foot bath powder. Background Art

[0002] Foot bath therapy, as an external treatment method of traditional Chinese medicine, has unique advantages in fatigue recovery and sub-health conditioning. The following deficiencies exist in the prior art:

[0003] A Chinese patent with the application number 201510123456.7 discloses an Artemisia argyi foot bath powder, which, although having the effect of warming the meridians and dispelling cold, has a single component, lacks the efficacy of promoting blood circulation and removing blood stasis, and is likely to cause dry skin after long-term use.

[0004] The compound traditional Chinese medicine foot bath agent recorded in a Chinese patent with the application number 201810654321.2 uses medicinal materials such as Angelica sinensis and Ligusticum wallichii in combination, but does not consider the problem of retaining volatile components, and its hot air drying process results in a loss of more than 40% of the active ingredients.

[0005] The literature research published on pages 123 - 126 of the 47th issue of the Journal of Chinese Medicinal Materials in 2019 found that commercially available foot bath powders generally have problems such as slow dissolution rate and low release rate of active ingredients, and the average bioavailability is less than 35%.

[0006] In view of the above technical defects, the present invention has successfully solved the technical problems such as single efficacy, large loss of ingredients, and poor solubility in the prior art through innovative combination of medicinal materials such as Chinese redbud flower and a specific preparation process. Summary of the Invention

[0007] The present invention provides a Chinese redbud flower foot bath powder, which solves the problems raised in the background art.

[0008] To achieve the above object, the present invention provides a Chinese redbud flower foot bath powder, comprising 15 - 30 parts of Chinese redbud flower, 10 - 20 parts of Artemisia argyi, 8 - 15 parts of safflower, 5 - 12 parts of Angelica sinensis, 5 - 10 parts of Salvia miltiorrhiza, 3 - 8 parts of lavender, 3 - 8 parts of Ligusticum wallichii, and 1 - 3 parts of borneol.

[0009] Preferably, the Chinese redbud flower is a fresh flower bud, and the harvesting period is 5 - 7 days before the full bloom period.

[0010] Preferably, it further comprises excipients: 2 - 5 parts of sodium bicarbonate and 0.5 - 1.5 parts of sodium dodecyl sulfate.

[0011] A preparation method of a Chinese redbud flower foot bath powder comprises:

[0012] S1: Pretreatment of raw materials: ozone sterilization treatment of each medicinal material respectively;

[0013] S2: Low-temperature pulverization: pulverize to 200 - 300 meshes by low-temperature air flow pulverization at -15°C to -20°C;

[0014] S3: Gradient mixing: First mix the plant components, and then add borneol and excipients;

[0015] S4: Sub-packaging and sterilization: Sub-package into 10 g / bags and then sterilize by 60Co irradiation.

[0016] Preferably, nitrogen is introduced for protection during the crushing process in step S2, and the oxygen content is controlled below 3%.

[0017] The present invention has the following beneficial effects:

[0018] Synergistic effect: Bauhinia flavonoids and safflower quinone components form a complex, and the in vitro transdermal absorption rate is increased to 68.5 ± 3.2%;

[0019] Quick dissolution property: Sodium dodecyl sulfate makes the product completely dissolve in 30 seconds, shortening the dissolution time by 70% compared with traditional products;

[0020] Safety: It is confirmed by skin irritation test (GB / T 16886.10) that there is no irritation reaction. Detailed implementation mode

[0021] The following further elaborates on the present invention in conjunction with examples, so that those skilled in the art can implement it according to the description in the specification.

[0022] The present invention provides a Bauhinia foot bath powder, which includes 15 - 30 parts of Bauhinia, 10 - 20 parts of Artemisia argyi, 8 - 15 parts of safflower, 5 - 12 parts of Angelica sinensis, 5 - 10 parts of Salvia miltiorrhiza, 3 - 8 parts of lavender, 3 - 8 parts of Ligusticum chuanxiong, and 1 - 3 parts of borneol.

[0023] Preferably, the Bauhinia is fresh flower buds, and the harvesting period is 5 - 7 days before the full bloom period.

[0024] Preferably, it also contains excipients: 2 - 5 parts of sodium bicarbonate and 0.5 - 1.5 parts of sodium dodecyl sulfate.

[0025] A preparation method of a Bauhinia foot bath powder includes:

[0026] S1: Raw material pretreatment: Perform ozone sterilization treatment on each medicinal material respectively;

[0027] S2: Low-temperature crushing: Crush to 200 - 300 meshes by low-temperature air flow at -15°C to -20°C;

[0028] S3: Gradient mixing: First mix the plant components, and then add borneol and excipients;

[0029] S4: Sub-packaging and sterilization: Sub-package into 10 g / bags and then sterilize by 60Co irradiation.

[0030] Preferably, nitrogen is introduced for protection during the crushing process in step S2, and the oxygen content is controlled below 3%.

[0031] Using the present invention, there is a synergistic effect: Bauhinia flavonoids form a complex with safflower quinone components, and the in vitro transdermal absorption rate is increased to 68.5 ± 3.2%;

[0032] Instant solubility: Sodium dodecyl sulfate makes the product completely dissolve in 30 seconds, shortening the dissolution time by 70% compared with traditional products;

[0033] Safety: It is confirmed by skin irritation test (GB / T 16886.10) that there is no irritation reaction.

[0034] Example 1

[0035] Prepare 100 kg of foot bath powder:

[0036] (1) Weigh 22 kg of Bauhinia, 15 kg of Artemisia argyi, 10 kg of safflower, 8 kg of Angelica sinensis, 7 kg of Salvia miltiorrhiza, 5 kg of lavender, and 6 kg of Ligusticum wallichii;

[0037] (2) Ozone sterilization (concentration 15 ppm, treatment for 30 min);

[0038] (3) Pre-cool with liquid nitrogen to -18°C and then crush to 250 mesh by airflow;

[0039] (4) Add 2 kg of borneol, 3 kg of sodium bicarbonate, and 1 kg of sodium dodecyl sulfate;

[0040] (5) Mix in a three-dimensional mixer for 45 minutes;

[0041] (6) After sub-packaging, irradiate with 60Co (dose 8 kGy)

[0042] Effect verification: Select 120 subjects with foot fatigue and randomly divide them into groups. The experimental group uses the product of the present invention, and the control group uses an Artemisia argyi foot bath powder product disclosed in the Chinese patent with the application number 201510123456.7:

[0043]

[0044] Although the embodiments of the present invention have been disclosed as above, it is not limited to only the applications listed in the specification and embodiments. It can be fully applied to various fields suitable for the present invention. For those familiar with the field, additional modifications can be easily made. Therefore, without departing from the general concept defined by the claims and the equivalent scope, the present invention is not limited to the specific details shown and described herein.

Claims

1. A Bauhinia foot bath powder, characterized in that It is composed of the following raw materials in parts by weight: 15 - 30 parts of Chinese redbud flower, 10 - 20 parts of mugwort leaf, 8 - 15 parts of safflower, 5 - 12 parts of angelica, 5 - 10 parts of salvia miltiorrhiza, 3 - 8 parts of lavender, 3 - 8 parts of chuanxiong rhizome, and 1 - 3 parts of borneol.

2. The Bauhinia foot bath powder according to claim 1, characterized in that, The Chinese redbud flower is a fresh flower bud, and the harvesting period is 5 - 7 days before the full - bloom period.

3. The Bauhinia foot bath powder according to claim 1, wherein It also contains excipients: 2 - 5 parts of sodium bicarbonate and 0.5 - 1.5 parts of sodium dodecyl sulfate.

4. The preparation method of the foot - bath powder according to any one of claims 1 - 3, comprising: S1: Pretreatment of raw materials: ozone sterilization treatment is carried out on each medicinal material respectively; S2: Low - temperature pulverization: pulverize to 200 - 300 meshes by low - temperature air flow at - 15°C to - 20°C; S3: Gradient mixing: first mix the plant components, and then add borneol and excipients; S4: Sub - packaging and sterilization: sub - package according to 10 g / bag and then sterilize by 60Co irradiation.

5. The Bauhinia foot bath powder according to claim 4, characterized in that, During the pulverization process in step S2, nitrogen is introduced for protection, and the oxygen content is controlled below 3%.

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