Veterinary drug for poultry cold and preparation method thereof

Abstract

The invention discloses a veterinary drug for poultry cold and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 20 parts of honeysuckle flower, 5 to 10 parts of radix isatidis, 5 to 10 parts of pine needle leaves, 3 to 5 parts of medicated leaven, 3 to 5 parts of herba ecliptae, 5 to 10 parts of scorched hawthorn fruit, 3 to 5 parts of oyster, 5 to 10 parts of herba taraxaci, 3 to 5 parts of calyx seu fructus physalis, 3 to 5 parts of radix ranunculi ternati, 10 to 20 parts of first composite auxiliary material, 1 to 3 parts of radix cynanchi auriculati, 5 to 10 parts of functional composition and 3 to 5 parts of second composite auxiliary material. According to the veterinary drug for poultry cold and the preparation method, the immunity of poultry and the digestive ability of own intestines and stomach can be comprehensively enhanced while anti-inflammation and bacteriostasis are realized, the efficacy of the veterinary drug for treating poultry cold is greatly enriched, and the purposes of treating cold and comprehensively improving the self-body resistance of poultry can be well achieved; therefore, the cultivation of the poultry is greatly facilitated.

Description

Technical Field

[0001] The present invention relates to the technical field of veterinary drugs, and particularly to a veterinary drug for poultry colds and a preparation method thereof. Background Art

[0002] In the process of poultry farming, large-scale diseases are likely to break out, such as colds. The cold symptoms are extremely easy to spread, seriously affecting the growth and egg production quality of poultry. If not treated in time, it will bring huge economic losses to farmers.

[0003] Existing veterinary drugs for treating poultry colds have relatively single efficacy and poor treatment effects. They only achieve the effect of anti-inflammatory and bacteriostatic, and cannot achieve the effect of comprehensively enhancing the immunity of poultry and the digestive ability of their own intestines and stomach while achieving anti-inflammatory and bacteriostatic. They cannot achieve the purpose of both treating colds and comprehensively improving the resistance of poultry themselves, thus bringing great inconvenience to poultry farming. Summary of the Invention

[0004] (1) Technical Problems to be Solved

[0005] In view of the deficiencies of the prior art, the present invention provides a veterinary drug for poultry colds and a preparation method thereof, which solve the problems that existing veterinary drugs for treating poultry colds have relatively single efficacy and poor treatment effects, only achieve the effect of anti-inflammatory and bacteriostatic, and cannot achieve the effect of comprehensively enhancing the immunity of poultry and the digestive ability of their own intestines and stomach while achieving anti-inflammatory and bacteriostatic, and cannot achieve the purpose of both treating colds and comprehensively improving the resistance of poultry themselves.

[0006] (2) Technical Solutions

[0007] To achieve the above object, the present invention is realized through the following technical solutions: A veterinary drug for poultry colds, the raw materials of which include, by weight: 10 - 20 parts of honeysuckle, 5 - 10 parts of isatis root, 5 - 10 parts of pine needles, 3 - 5 parts of divaricate salsify fruit, 3 - 5 parts of eclipta prostrata, 5 - 10 parts of hawthorn, 3 - 5 parts of oyster, 5 - 10 parts of dandelion, 3 - 5 parts of Chinese lantern, 3 - 5 parts of cat's claw grass, 10 - 20 parts of the first composite auxiliary material, 1 - 3 parts of cynanchum wilfordii, 5 - 10 parts of the efficacy composition, and 3 - 5 parts of the second composite auxiliary material.

[0008] Preferably, the raw materials of which include, by weight: 15 parts of honeysuckle, 7 parts of isatis root, 7 parts of pine needles, 4 parts of divaricate salsify fruit, 4 parts of eclipta prostrata, 7 parts of hawthorn, 4 parts of oyster, 7 parts of dandelion, 4 parts of Chinese lantern, 4 parts of cat's claw grass, 15 parts of the first composite auxiliary material, 2 parts of cynanchum wilfordii, 7 parts of the efficacy composition, and 4 parts of the second composite auxiliary material.

[0009] Preferably, the raw materials by weight include: 10 parts of honeysuckle, 5 parts of isatis root, 5 parts of pine needles, 3 parts of medicated leaven, 3 parts of eclipta prostrata, 5 parts of stir-fried hawthorn, 3 parts of oyster, 5 parts of dandelion, 3 parts of Chinese lantern, 3 parts of cat's claw, 10 parts of the first composite auxiliary material, 1 part of cynanchum wilfordii, 5 parts of the efficacy composition, and 3 parts of the second composite auxiliary material.

[0010] Preferably, the raw materials by weight include: 20 parts of honeysuckle, 10 parts of isatis root, 10 parts of pine needles, 5 parts of medicated leaven, 5 parts of eclipta prostrata, 10 parts of stir-fried hawthorn, 5 parts of oyster, 10 parts of dandelion, 5 parts of Chinese lantern, 5 parts of cat's claw, 20 parts of the first composite auxiliary material, 3 parts of cynanchum wilfordii, 10 parts of the efficacy composition, and 5 parts of the second composite auxiliary material.

[0011] Preferably, the first composite auxiliary material is any combination of two or more of dried tangerine peel, borneol, cortex fraxini, chinese starjasmine stem, cortex ailanthi, costus root or atractylodes lancea.

[0012] Preferably, the efficacy composition is any combination of two or more of mugwort leaf, anemarrhena asphodeloides, astragalus membranaceus, wild chrysanthemum or perilla leaf.

[0013] Preferably, the second composite auxiliary material is any combination of two or more of folium isatidis, liquorice, bupleurum chinense, semiaquilegia adoxoides, wild jujube seed or divaricate saposhnikovia root.

[0014] The present invention also provides a preparation method of a veterinary drug for poultry colds, specifically including the following steps:

[0015] S1. Ingredient processing: Weigh the required parts by weight of honeysuckle, isatis root, pine needles, medicated leaven, eclipta prostrata, stir-fried hawthorn, oyster, dandelion, Chinese lantern, cat's claw, the first composite auxiliary material, cynanchum wilfordii, the efficacy composition and the second composite auxiliary material respectively through weighing equipment;

[0016] S2. Crushing and percolation processing: First wash the components weighed in step S1 2 - 3 times with clear water, drain, then dry and crush them in sequence to obtain a powder of 100 - 110 meshes. Using ethanol as a solvent, impregnate for 2 - 3 days, then slowly percolate at a speed of 7 - 10 ml per minute per kilogram, collect the percolate with a weight 5 - 7 times that of the medicinal materials, recover the ethanol until there is no alcohol smell, and obtain the ethanol extract and the medicinal residues for standby

[0017] S3. Boiling and filtration processing: Add water with a weight 2 - 5 times that of the total powder weight to the medicinal residues collected in step S2, decoct for 1 - 2 h, filter to obtain the filtrate, then add water with a weight 2 - 3 times that of the medicinal residues, decoct for 1 - 2 h to obtain the filtrate, combine the two filtrates, concentrate the filtrate to 30 - 40% of the previous volume, wait for the filtrate to cool down to 50 - 60 °C, then add ethanol accounting for 20 - 40% of the volume of the concentrated filtrate for ethanol precipitation, stand for 48 h and then recover the ethanol under reduced pressure;

[0018] S4. Concentration and powder preparation: Appropriate amount of volatile oil inclusion compound and dextrin are added, stirred evenly, and appropriate amount of distilled water is added. Finally, the relative density of the extract is 1.12. It is filtered through a 100-110 mesh sieve. After the filtrate is spray-dried to obtain powder, it is dry-extruded into granules to obtain the granules.

[0019] (III) Beneficial effects

[0020] The present invention provides a veterinary drug for poultry colds and a preparation method thereof. Compared with the prior art, it has the following beneficial effects: The veterinary drug for poultry colds and the preparation method thereof have raw materials by weight including: 10-20 parts of honeysuckle, 5-10 parts of isatis root, 5-10 parts of pine needles, 3-5 parts of medicated leaven, 3-5 parts of eclipta prostrata, 5-10 parts of stir-fried hawthorn, 3-5 parts of oyster, 5-10 parts of dandelion, 3-5 parts of calyx seu fructus physalis, 3-5 parts of cat's claw grass, 10-20 parts of the first compound auxiliary material, 1-3 parts of cynanchum wilfordii, 5-10 parts of the efficacy composition, and 3-5 parts of the second compound auxiliary material. It can achieve the purpose of comprehensively enhancing the immunity of poultry and the digestive ability of its own gastrointestinal tract while realizing anti-inflammatory and antibacterial effects, greatly enriching the efficacy of veterinary drugs for treating poultry colds, and well achieving the purpose of being able to treat colds and comprehensively improving the self-resistance of poultry, thus greatly facilitating the breeding of poultry. Description of the drawings

[0021] Figure 1 It is a flow chart of the preparation method of the present invention. Specific embodiments

[0022] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work belong to the scope of protection of the present invention.

[0023] Please refer to Figure 1 , the embodiments of the present invention provide a technical solution: A veterinary drug for poultry colds and a preparation method thereof, specifically including the following embodiments:

[0024] Example 1: A veterinary drug for avian cold, the raw materials of which include, by weight: 15 parts of honeysuckle, 7 parts of isatis root, 7 parts of pine needles, 4 parts of medicated leaven, 4 parts of eclipta prostrata, 7 parts of hawthorn fruit, 4 parts of oyster, 7 parts of dandelion, 4 parts of calyx seu fructus physalis, 4 parts of cat's claw grass, 15 parts of the first compound excipient, 2 parts of cynanchum wilfordii, 7 parts of the efficacy composition, and 4 parts of the second compound excipient. The first compound excipient is a composition of tangerine peel, borneol, cortex fraxini, chinese starjasmine stem, cortex ailanthi, costus root and atractylodes lancea. The efficacy composition is a composition of artemisia argyi, anemarrhena asphodeloides, astragalus membranaceus, wild chrysanthemum and perilla leaf. The second compound excipient is a composition of folium isatidis, liquorice, bupleurum chinense, semiaquilegia adoxoides, wild jujube seed and ledebouriella seseloides.

[0025] The embodiment of the present invention also provides a preparation method of a veterinary drug for avian cold, which specifically includes the following steps:

[0026] S1. Ingredient processing: Weigh the required parts by weight of honeysuckle, isatis root, pine needles, medicated leaven, eclipta prostrata, hawthorn fruit, oyster, dandelion, calyx seu fructus physalis, cat's claw grass, the first compound excipient, cynanchum wilfordii, the efficacy composition and the second compound excipient respectively through weighing equipment;

[0027] S2. Crushing and percolation processing: Wash the components weighed in step S1 twice with clear water, drain, then dry and crush them in sequence to obtain a powder of 105 mesh. Use ethanol as the solvent, soak for 2 days, and then slowly percolate at a speed of 8 ml per minute per kilogram to collect the percolate with a weight 6 times that of the medicinal materials. Recover the ethanol until there is no alcohol smell to obtain the ethanol extract and the medicinal residues for standby

[0028] S3. Decoction and filtration processing: Add 3 times the weight of water of the total powder weight to the medicinal residues collected in step S2, decoct for 1.5 h, filter to obtain the filtrate, then add 2.5 times the amount of water to the medicinal residues, decoct for 1.5 h to obtain the filtrate, combine the two filtrates, concentrate the filtrate to 35% of the previous volume, wait for the filtrate to cool down to 55 °C, then add ethanol accounting for 30% of the volume of the concentrated filtrate for alcohol precipitation, stand for 48 h and then recover the ethanol under reduced pressure;

[0029] S4. Concentration and powder making processing: Add appropriate amount of volatile oil inclusion compound and dextrin, stir evenly, add appropriate amount of distilled water, finally obtain an extract with a relative density of 1.12, filter through a 105-mesh sieve, spray-dry the filtrate to obtain a powder, and then granulate by dry extrusion to obtain the granules.

[0030] Example 2: A veterinary drug for poultry colds, the raw materials of which by weight include: 10 parts of honeysuckle, 5 parts of isatis root, 5 parts of pine needles, 3 parts of medicated leaven, 3 parts of eclipta prostrata, 5 parts of stir-fried hawthorn, 3 parts of oyster, 5 parts of dandelion, 3 parts of calyx seu fructus physalis, 3 parts of cat's claw herb, 10 parts of the first compound auxiliary material, 1 part of cynanchum wilfordii, 5 parts of the efficacy composition, and 3 parts of the second compound auxiliary material. The first compound auxiliary material is a composition of pericarpium citri reticulatae, borneol, cortex fraxini, and trachelospermum jasminoides; the efficacy composition is a composition of folium artemisiae argyi, anemarrhena asphodeloides, and astragalus membranaceus; the second compound auxiliary material is a composition of folium isatidis, licorice, and bupleurum chinense.

[0031] The embodiment of the present invention also provides a preparation method of a veterinary drug for poultry colds, which specifically includes the following steps:

[0032] S1. Ingredient processing: Weigh the required parts by weight of honeysuckle, isatis root, pine needles, medicated leaven, eclipta prostrata, stir-fried hawthorn, oyster, dandelion, calyx seu fructus physalis, cat's claw herb, the first compound auxiliary material, cynanchum wilfordii, the efficacy composition, and the second compound auxiliary material respectively through weighing equipment;

[0033] S2. Crushing and percolation processing: First wash the components weighed in step S1 three times with clear water, drain, then dry and crush them in sequence to obtain a powder of 110 meshes. Use ethanol as a solvent, soak for 3 days, and then slowly percolate at a speed of 7 ml per minute per kilogram to collect a percolate with a weight 5 times that of the medicinal materials. Recover ethanol until there is no alcohol smell to obtain an ethanol extract and medicinal residues for standby.

[0034] S3. Decoction and filtration processing: Add 2 times the weight of water of the total powder weight to the medicinal residues collected in step S2, decoct for 1 h, filter to obtain a filtrate, then add 2 times the amount of water to the medicinal residues and decoct for 1 h to obtain a filtrate. Combine the two filtrates, concentrate the filtrate to 30% of the previous volume. When the filtrate cools to 50 °C, add ethanol accounting for 20% of the volume of the concentrated filtrate for alcohol precipitation, stand for 48 h, and then recover ethanol under reduced pressure;

[0035] S4. Concentration and powder making processing: Add an appropriate amount of volatile oil inclusion compound and dextrin, stir evenly, add an appropriate amount of distilled water. Finally, the relative density of the extract obtained is 1.12. Filter through a 100-mesh sieve, and after the filtrate is spray-dried to obtain a powder, dry extrusion granulation is carried out to obtain granules.

[0036] Example 3: A veterinary drug for poultry colds, the raw materials of which by weight include: 20 parts of honeysuckle, 10 parts of isatis root, 10 parts of pine needles, 5 parts of medicated leaven, 5 parts of eclipta prostrata, 10 parts of stir-fried hawthorn, 5 parts of oyster, 10 parts of dandelion, 5 parts of calyx seu fructus physalis, 5 parts of cat's claw herb, 20 parts of the first compound auxiliary material, 3 parts of cynanchum wilfordii, 10 parts of the efficacy composition, and 5 parts of the second compound auxiliary material. The first compound auxiliary material is a composition of cortex ailanthi altissimae, Aucklandia lappa, and atractylodes lancea; the efficacy composition is a composition of wild chrysanthemum and perilla leaf; the second compound auxiliary material is a composition of semiaquilegia adoxoides, wild jujube seed, and ledebouriella seseloides.

[0037] An embodiment of the present invention also provides a preparation method of a veterinary drug for poultry colds, which specifically includes the following steps:

[0038] S1. Ingredient treatment: Weigh the required parts by weight of honeysuckle, isatis root, pine needles, medicated leaven, eclipta prostrata, hawthorn fruit, oyster, dandelion, Chinese lantern, cat's claw, the first composite auxiliary material, cynanchum wilfordii, the efficacy composition and the second composite auxiliary material respectively through weighing equipment;

[0039] S2. Crushing and percolation treatment: First, wash the components weighed in step S1 twice with clear water. After draining, dry and crush them in sequence to obtain a powder with a mesh size of 110. Using ethanol as a solvent, impregnate for 2 days, and then slowly percolate at a speed of 10 ml per minute per kilogram to collect a percolate with a weight 7 times that of the medicinal materials. Recover the ethanol until there is no alcohol smell to obtain an ethanol extract and medicinal residues for standby

[0040] S3. Decoction and filtration treatment: Add 5 times the weight of water of the total powder weight to the medicinal residues collected in step S2, decoct for 2 h, filter to obtain a filtrate, then add 3 times the amount of water to the medicinal residues, decoct for 2 h to obtain a filtrate, combine the two filtrates, concentrate the filtrate to 40% of the previous volume, wait for the filtrate to cool to 60 °C, and then add ethanol accounting for 40% of the volume of the concentrated filtrate for alcohol precipitation. After standing for 48 h, recover the ethanol under reduced pressure;

[0041] S4. Concentration and powder making treatment: Add an appropriate amount of volatile oil inclusion complex and dextrin, stir evenly, add an appropriate amount of distilled water, and finally obtain an extract with a relative density of 1.12. Filter through a 110-mesh sieve, spray-dry the filtrate to obtain a powder, and then dry-extrude to granulate to obtain granules.

[0042] In summary, the present invention can achieve the purpose of comprehensively enhancing the immunity of poultry and the digestive ability of their own stomachs while realizing anti-inflammatory and antibacterial effects, greatly enriching the efficacy of veterinary drugs for treating poultry colds, and well achieving the purpose of both treating colds and comprehensively improving the self-resistance of poultry, thus greatly facilitating the breeding of poultry.

[0043] At the same time, the content not described in detail in this specification belongs to the prior art well-known to those skilled in the art.

[0044] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprises", "comprising" or any other variation thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or elements inherent to such process, method, article or device.

[0045] Although embodiments of the present invention have been shown and described, those of ordinary skill in the art will understand that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A veterinary drug for poultry colds, characterized in that: Its raw materials by weight include: 10-20 parts of honeysuckle, 5-10 parts of isatis root, 5-10 parts of pine needles, 3-5 parts of medicated leaven, 3-5 parts of eclipta prostrata, 5-10 parts of stir-fried hawthorn, 3-5 parts of oyster, 5-10 parts of dandelion, 3-5 parts of chinese lantern, 3-5 parts of cat's claw herb, 10-20 parts of the first compound excipient, 1-3 parts of cynanchum wilfordii, 5-10 parts of the efficacy composition, and 3-5 parts of the second compound excipient.

2. The veterinary drug for poultry cold according to claim 1, wherein: Its raw materials by weight include: 15 parts of honeysuckle, 7 parts of isatis root, 7 parts of pine needles, 4 parts of medicated leaven, 4 parts of eclipta prostrata, 7 parts of stir-fried hawthorn, 4 parts of oyster, 7 parts of dandelion, 4 parts of chinese lantern, 4 parts of cat's claw herb, 15 parts of the first compound excipient, 2 parts of cynanchum wilfordii, 7 parts of the efficacy composition, and 4 parts of the second compound excipient.

3. A veterinary drug for poultry colds according to claim 1, characterized in that: Its raw materials by weight include: 10 parts of honeysuckle, 5 parts of isatis root, 5 parts of pine needles, 3 parts of medicated leaven, 3 parts of eclipta prostrata, 5 parts of stir-fried hawthorn, 3 parts of oyster, 5 parts of dandelion, 3 parts of chinese lantern, 3 parts of cat's claw herb, 10 parts of the first compound excipient, 1 part of cynanchum wilfordii, 5 parts of the efficacy composition, and 3 parts of the second compound excipient.

4. A veterinary drug for poultry cold according to claim 1, characterized in that: Its raw materials by weight include: 20 parts of honeysuckle, 10 parts of isatis root, 10 parts of pine needles, 5 parts of medicated leaven, 5 parts of eclipta prostrata, 10 parts of stir-fried hawthorn, 5 parts of oyster, 10 parts of dandelion, 5 parts of chinese lantern, 5 parts of cat's claw herb, 20 parts of the first compound excipient, 3 parts of cynanchum wilfordii, 10 parts of the efficacy composition, and 5 parts of the second compound excipient.

5. A veterinary drug for poultry cold according to any one of claims 1-4, characterized in that: The first compound excipient is any combination of two or more of tangerine peel, borneol, cortex fraxini, chinese starjasmine stem, cortex ailanthi, saussurea costus or atractylodes lancea.

6. A veterinary drug for poultry cold according to any one of claims 1-4, characterized in that: The efficacy composition is any combination of two or more of artemisia argyi, anemarrhena asphodeloides, astragalus membranaceus, wild chrysanthemum or perilla leaf.

7. A veterinary drug for poultry cold according to any one of claims 1-4, characterized in that: The second compound excipient is any combination of two or more of folium isatidis, liquorice root, bupleurum chinense, semiaquilegia adoxoides, wild jujube seed or divaricate saposhnikovia root.

8. A method for preparing the veterinary drug for poultry cold as described in any one of claims 1-4, characterized in that: Specifically, it includes the following steps: S1. Batching treatment: Weigh the required parts by weight of honeysuckle, isatis root, pine needles, medicated leaven, eclipta prostrata, stir-fried hawthorn, oyster, dandelion, chinese lantern, cat's claw herb, the first compound excipient, cynanchum wilfordii, the efficacy composition, and the second compound excipient respectively through weighing equipment; S2. Crushing and percolation treatment: Wash the components weighed in step S1 with clear water 2-3 times, drain, then dry and crush them in sequence to obtain a powder of 100-110 mesh. Use ethanol as the solvent, impregnate for 2-3 days, and then slowly percolate at a rate of 7-10 ml per kilogram per minute to collect the percolate with a weight 5-7 times that of the medicinal materials. Recover the ethanol until there is no alcohol smell to obtain the ethanol extract and the medicinal residues for standby. S3. Decoction and filtration treatment: Add water 2-5 times the weight of the total powder to the medicinal residues collected in step S2, decoct for 1-2 h, filter to obtain the filtrate. Then add water 2-3 times the amount to the medicinal residues, decoct for 1-2 h to obtain the filtrate. Combine the two filtrates, concentrate the filtrate to 30-40% of the previous volume. Wait until the filtrate cools to 50-60 °C, then add ethanol accounting for 20-40% of the volume of the concentrated filtrate for alcohol precipitation. After standing for 48 h, recover the ethanol under reduced pressure; S4. Concentrated powder preparation: Add appropriate amount of volatile oil inclusion compound and dextrin, stir evenly, add appropriate amount of distilled water. Finally, the relative density of the extract is 1.

12. Filter through a 100-110 mesh sieve. After the filtrate is spray-dried to obtain powder, it is dry-extruded into granules to obtain the granules.

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