Medicinal and edible composition as well as preparation method and application thereof

Abstract

The invention discloses a medicinal and edible composition and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine, and the medicinal and edible composition comprises peach kernel, dried orange peel, hawthorn, wolfberry, gastrodia elata, cassia seed, platycodon grandiflorum, poria cocos, honey-fried licorice root, panax notoginseng fibrous root, panax notoginseng flower and the like. The formula is designed from the comprehensive conditioning angles of promoting blood circulation to remove blood stasis, removing heat from the liver, purging fire, strengthening the spleen, clearing damp, nourishing yin, enriching blood and the like, and the compatibility is reasonable, so that the composition can be beneficial to maintaining the health level of blood fat and avoiding the harm caused by increase of blood fat, and has the remarkable effect of reducing total cholesterol and triglyceride. Moreover, the composition disclosed by the invention is prepared from natural medicinal and edible Chinese herbal medicines, has no side effect or small side effect on a human body, can nourish the body, can be taken for a long time, and is wide in applicable crowd and high in practical application value.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a medicine and food homologous composition, a preparation method thereof, and an application thereof. Background Art

[0002] According to traditional Chinese medicine theory, the main causes of hyperlipidemia can be summarized into the following two aspects: one is excessive consumption of fatty and sweet foods, which damages the spleen and stomach. At the same time, the dredging function of the liver and gallbladder is not smooth, and it cannot secrete and transport essence juice, resulting in the disorder of the spleen's function of digesting grains and transporting and transforming, and being transformed into phlegm turbidity; the other is that after middle age, the kidney qi gradually declines, both the yin and yang of the kidney are deficient, the ministerial fire stirs wildly, causing the liver yang to hyperactive, and even transforming into fire. When the wood is prosperous, it invades the earth, causing the disorder of the spleen and stomach's transportation and distribution function, the accumulation of dampness and heat, and the endogenous generation of phlegm turbidity. Due to the internal stagnation of phlegm turbidity, the invasion of blood vessels, and the obstruction of blood circulation, symptoms such as chest pain and syncope occur, which is consistent with the modern medical view that lipid metabolism disorders are one of the pathogenic factors of ischemic heart disease and cerebrovascular diseases. Hyperlipidemia belongs to the categories of "phlegm retention", "stroke", and "vertigo", and the disease location is in the blood vessels, which is closely related to phlegm turbidity and blood stasis.

[0003] Due to the relatively high incidence rate of hyperlipidemia and the lack of effective drugs for the current medical treatment of hyperlipidemia, which only treats the symptoms but not the root cause, many patients suffer from the disease for a long time, causing great physical and mental pressure and economic burden to the patients. Moreover, most drugs are Western medicines or combination drugs, which have certain side effects.

[0004] Therefore, developing products with no side effects or small side effects on the human body, which can be used for a long time and help maintain a healthy blood lipid level, has extremely high economic value and social significance. Summary of the Invention

[0005] The present invention aims to solve at least one of the technical problems existing in the prior art. For this purpose, the present invention provides a medicine and food homologous composition, a preparation method thereof, and an application thereof, aiming to solve the problem that most of the current drugs for treating hyperlipidemia or maintaining a healthy blood lipid level have side effects on the human body, and to provide a product that can effectively maintain a healthy blood lipid level and has no side effects or small side effects on the human body.

[0006] In the first aspect of the present invention, a medicine and food homologous composition is provided, which comprises the following components in parts by weight: 5 - 36 parts of peach kernels, 5 - 40 parts of dried tangerine peel, 2 - 30 parts of hawthorn, 2 - 28 parts of wolfberries, 1 - 25 parts of gastrodia elata, 1 - 25 parts of cassia seeds, 1 - 25 parts of platycodon grandiflorum, 1 - 25 parts of poria cocos, 1 - 20 parts of roasted licorice root, 1 - 10 parts of radix notoginseng fibrous roots, and 1 - 10 parts of flos notoginseng.

[0007] The medicated and edible homologous composition according to the embodiments of the present invention has at least the following beneficial effects: The medicated and edible homologous composition provided by the present invention includes peach kernels, dried tangerine peels, hawthorns, wolfberries, gastrodia elata, cassia seeds, platycodon grandiflorum, poria cocos, roasted licorice roots, notoginseng fibrous roots, notoginseng flowers, etc. Starting from the comprehensive conditioning perspectives of promoting blood circulation to remove blood stasis, clearing liver fire, strengthening the spleen and removing dampness, nourishing yin and enriching blood, etc., the present invention designs the formula with reasonable compatibility, enabling the composition to contribute to maintaining the healthy level of blood lipids, avoiding the harms brought by increased blood lipids, and having a significant effect on reducing total cholesterol and triglycerides. Moreover, the composition of the present invention is prepared from natural medicated and edible homologous Chinese herbal medicines, has no side effects or minor side effects on the human body, can nourish the body, can be taken for a long time, has a wide range of applicable populations, and has high practical application value.

[0008] The properties, tastes, meridian tropisms, and effects of the drugs in the composition of the present invention are as follows:

[0009] Peach kernel: Bitter, sweet, and flat. It belongs to the heart, liver, and large intestine meridians. It has the effects of promoting blood circulation to remove blood stasis, moistening the intestines and relieving constipation, and relieving cough and asthma. It is used for amenorrhea and dysmenorrhea, mass in the abdomen, lung abscess and intestinal abscess, traumatic injury, intestinal dryness and constipation, cough and asthma.

[0010] Notoginseng fibrous root: Sweet, slightly bitter, and warm. It belongs to the liver and stomach meridians. It has the effects of dissipating stasis and stopping bleeding, and detumescence and relieving pain. It is used for hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic bleeding, chest and abdominal stabbing pain, traumatic injury and swelling pain.

[0011] Hawthorn: Sour, sweet, and slightly warm. It belongs to the spleen, stomach, and liver meridians. It has the effects of promoting digestion and strengthening the stomach, promoting qi circulation and dispersing stasis, and reducing turbidity and lipid-lowering. It is used for food retention, fullness in the stomach and abdomen, diarrhea and abdominal pain, stagnant blood amenorrhea, postpartum stasis obstruction, heart and abdominal stabbing pain, chest impediment pain, hernia pain, hyperlipidemia.

[0012] Wolfberry: Sweet and flat. It belongs to the liver and kidney meridians. It has the effects of nourishing the liver and kidney, and improving eyesight. It is used for consumptive fatigue with spermatorrhea, soreness and weakness of the waist and knees, dizziness and tinnitus, impotence and spermatorrhea, internal heat and polydipsia, sallow complexion due to blood deficiency, and dim vision.

[0013] Gastrodia elata: Sweet and flat. It belongs to the liver meridian. It has the effects of calming endogenous wind and stopping convulsions, suppressing hyperactive liver yang, and dispelling wind and dredging collaterals. It is used for infantile convulsions, epilepsy convulsions, tetanus, headache and dizziness, inability to move hands and feet, limb numbness, and rheumatic arthralgia.

[0014] Cassia seed: Sweet, bitter, salty, and slightly cold. It belongs to the liver and large intestine meridians. It has the effects of clearing heat and improving eyesight, and moistening the intestines and relieving constipation. It is used for redness, swelling, and pain of the eyes, photophobia and excessive tearing, headache and dizziness, dim vision, and constipation.

[0015] Dried tangerine peel: Bitter, pungent, and warm. It belongs to the lung and spleen meridians. It has the effects of regulating qi and strengthening the spleen, and drying dampness and resolving phlegm. It is used for abdominal distension and fullness, anorexia, vomiting and diarrhea, and cough with excessive phlegm.

[0016] Platycodon grandiflorum: Bitter, pungent, flat. It acts on the lung meridian. It has the effects of dispersing the lung qi, relieving sore throat, resolving phlegm, and expelling pus. It is used for excessive phlegm and cough, chest distress, sore throat with hoarse voice, and lung abscess with expectoration of pus.

[0017] Poria cocos: Sweet, light, flat. It acts on the heart, lung, spleen, and kidney meridians. It has the effects of promoting diuresis to eliminate dampness, strengthening the spleen, and calming the heart. It is used for edema with scanty urination, dizziness and palpitation due to retention of phlegm-fluid, poor appetite due to spleen deficiency, loose stools and diarrhea, restlessness of the mind, palpitation, and insomnia.

[0018] Prepared Licorice Root: Sweet, flat. It acts on the heart, lung, spleen, and stomach meridians. It has the effects of tonifying the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, alleviating spasm and pain, and harmonizing various medicinal herbs. It is used for weakness of the spleen and stomach, lassitude and fatigue, palpitations and shortness of breath, excessive phlegm and cough, spasmodic pain in the epigastric and abdominal regions and the extremities, carbuncles and sores, and relieving the toxicity and potency of medicinal herbs.

[0019] Flos Notoginseng: Sweet, cool. It acts on the liver and kidney meridians. It has the effects of clearing heat and promoting fluid production, soothing the liver and reducing blood pressure. It is used for thirst due to body fluid injury, sore throat with hoarse voice, and hypertension.

[0020] The compatibility basis of traditional Chinese medicine in the prescription is as follows: Semen Persicae promotes blood circulation to remove stasis and moistens dryness; Flos Notoginseng clears heat and detoxifies, moistens the intestines and resolves phlegm; Radix Notoginseng fibrous root promotes blood circulation to disperse stasis and relieve pain. They together serve as the monarch drugs. Fructus Crataegi helps the monarch drugs promote qi circulation and disperse stasis; Fructus Lycii nourishes essence and blood. They together serve as the minister drugs. Rhizoma Gastrodiae and Semen Cassiae clear the liver and purge fire; Pericarpium Citri Reticulatae Viride, Radix Platycodonis, and Poria cocos promote qi circulation and dry dampness, strengthen the spleen and nourish the stomach. Radix Platycodonis guides the medicinal herbs upward to reach the blood mansion and serves as the assistant drug. Licorice root alleviates spasm and harmonizes various medicinal herbs and serves as the envoy drug. The compatibility of the raw materials of this composition exerts the combined effects of promoting blood circulation to remove stasis, resolving phlegm and promoting diuresis, and is used for syndromes such as hyperactivity of liver-yang, internal obstruction of blood stasis, and obstruction of phlegm-dampness in the middle, achieving the effect of helping to maintain a healthy blood lipid level.

[0021] In some embodiments of the present invention, the medicine and food homologous composition comprises the following components in parts by weight: 18 - 36 parts of Semen Persicae, 18 - 40 parts of Pericarpium Citri Reticulatae Viride, 12 - 30 parts of Fructus Crataegi, 12 - 28 parts of Fructus Lycii, 9 - 25 parts of Rhizoma Gastrodiae, 9 - 25 parts of Semen Cassiae, 9 - 25 parts of Radix Platycodonis, 9 - 25 parts of Poria cocos, 6 - 20 parts of Prepared Licorice Root, 5 - 10 parts of Radix Notoginseng fibrous root, and 5 - 10 parts of Flos Notoginseng.

[0022] In some preferred embodiments of the present invention, the medicine and food homologous composition comprises the following components in parts by weight: 18 parts of Semen Persicae, 18 parts of Pericarpium Citri Reticulatae Viride, 12 parts of Fructus Crataegi, 12 parts of Fructus Lycii, 9 parts of Rhizoma Gastrodiae, 9 parts of Semen Cassiae, 9 parts of Radix Platycodonis, 9 parts of Poria cocos, 6 parts of Prepared Licorice Root, 5 parts of Radix Notoginseng fibrous root, and 5 parts of Flos Notoginseng.

[0023] The present invention designs the formula from the comprehensive conditioning aspects of promoting blood circulation to remove stasis, clearing the liver and purging fire, strengthening the spleen and removing dampness, nourishing yin and enriching blood, etc., reasonably adjusts the ratio of various traditional Chinese medicines, makes their medicinal properties blend with each other and the compatibility is reasonable, so that this composition can help maintain the function of a healthy blood lipid level, avoid the harm caused by increased blood lipids, and has a significant effect of reducing total cholesterol and triglycerides.

[0024] In some embodiments of the present invention, the medicated and edible homologous composition further comprises a pharmaceutically acceptable excipient.

[0025] Preferably, the excipient comprises at least one of a filler, a lubricant, a dispersant, a wetting agent, a binder, an antioxidant, and a preservative.

[0026] In some embodiments of the present invention, the medicated and edible homologous composition can be prepared into any one of a decoction, tablets, powders, fine powders, pills, granules, oral liquids, capsules, or extracts.

[0027] In a second aspect of the present invention, a method for preparing the above-mentioned medicated and edible homologous composition is provided, comprising the steps of: weighing the medicinal materials of each component according to the weight ratio, soaking them in water for 30 - 60 min, decocting them 2 - 3 times, combining the medicinal liquids obtained from multiple decoctions, and concentrating the medicinal liquid to obtain a thick paste of the composition.

[0028] The method for preparing the medicated and edible homologous composition according to the embodiments of the present invention has at least the following beneficial effects: The preparation method of the present invention is simple and easy to implement, does not require complex equipment, and is closer to life. After obtaining the thick paste of the composition, it can be directly applied, or further prepared into a dry product, beverage, etc. of the composition. At the same time, there is a possibility of large-scale production, without the need to spend a large amount of time decocting medicinal materials each time, and it can be applied to the preparation of batch pharmaceutical preparations or health products.

[0029] In some embodiments of the present invention, after weighing the medicinal materials of each component according to the weight ratio and pouring them into an extraction tank, 8 - 10 times the total weight of the medicinal materials of water is added and soaked for 30 - 60 min. Preferably, it is soaked for 60 min.

[0030] In some embodiments of the present invention, after the medicinal materials are soaked in water for 30 - 60 min, they are decocted 2 - 3 times, 2 - 3 h each time, and the medicinal liquids obtained from multiple decoctions are combined. Preferably, it is decocted 2 times, 2 h each time.

[0031] In some embodiments of the present invention, the specific steps for concentrating the medicinal liquid to obtain a thick paste of the composition are as follows: filtering the medicinal liquid, transferring the supernatant to an evaporation tank, heating and concentrating it to a specific gravity of 1.05 - 1.20 g / cm3 to obtain a concentrated liquid; filtering and removing impurities from the concentrated liquid, and then filtering it through a ceramic membrane, and collecting the filtrate; concentrating the filtrate again to a thick paste with a specific gravity of 1.25 - 1.35 g / cm3, that is, obtaining the thick paste of the composition.

[0032] In a specific embodiment of the present invention, the steps for preparing the thick paste of the above-mentioned medicated and edible homologous composition are as follows:

[0033] (1)Weigh the medicinal materials according to the weight ratio of each component of the composition. After pouring them into the extraction tank, add 8 - 10 times the total weight of the medicinal materials of water and soak for 30 - 60 minutes;

[0034] (2)Heat the soaked medicinal materials to boiling and extract for 2 hours, filter, and take the supernatant for later use;

[0035] (3)For the medicinal materials after extraction and filtration, add 8 - 10 times the weight of water again, heat to boiling for 2 hours, filter, and take the supernatant;

[0036] (4)Combine the supernatants filtered twice in steps (2) and (3), transfer them to the evaporation tank, and heat and concentrate to a specific gravity of about 1.05 - 1.20 g / cm3;

[0037] (5)Filter and remove impurities from the concentrated liquid in step (4), and then filter through a ceramic membrane to collect the filtrate;

[0038] (6)Concentrate the filtrate in step (5) to a thick paste with a specific gravity of 1.25 - 1.35 g / cm3, which is the thick paste of the composition.

[0039] In some embodiments of the present invention, after obtaining the thick paste of the composition, the steps further include: detecting the solid content of the thick paste of the composition, adding the same weight of filling adjuvants according to its solid content for mixing, and subjecting the obtained mixture to vacuum drying to obtain the dried product of the composition.

[0040] Specifically, the filling adjuvants can be starch - based, sugar - based, cellulose - based adjuvants or any other commonly used pharmaceutically acceptable filling adjuvants.

[0041] In a specific embodiment of the present invention, after obtaining the thick paste of the composition, it can also be prepared into a dried product. The steps are as follows:

[0042] (7a)Detect the solid content of the thick paste of the composition in step (6);

[0043] (8a)Take a certain weight of the thick paste of the composition and mix it according to its solid content and the same weight of filling adjuvants;

[0044] (9a)Put the mixture in step (8a) into a vacuum drying oven at 60 °C for drying;

[0045] (10a)Crush the dried substance in step (9a) and pass it through a 100 - mesh sieve to obtain the dried product of the composition.

[0046] In some embodiments of the present invention, after obtaining the thick paste of the composition, the steps further include: adding food additives and water to the thick paste of the composition to prepare a solution, and dispensing the solution according to a predetermined dosage, and obtaining the composition beverage after sterilization.

[0047] In a specific embodiment of the present invention, after obtaining the composition extract, it can also be prepared into a beverage, and the steps are as follows:

[0048] (7b) Add food additives and water to the composition extract in step (6) to prepare a solution;

[0049] (8b) Dispense the solution in step (7b) according to a predetermined dosage, sterilize it at 120 °C for 15 minutes, and cool to obtain the composition beverage.

[0050] Specifically, the food additives may be sweeteners, flavors, spices and other food additives that comply with the regulations.

[0051] In some embodiments of the present invention, the medicine and food homology composition can be prepared into any one of decoctions, tablets, powders, powder agents, pills, granules, oral liquids, capsules or paste extracts, or prepared into health foods, beverages, etc.

[0052] The present invention can select a suitable preparation method for the above-mentioned medicine and food homology composition according to the dosage form required in practice. For example, if it is used as a traditional Chinese medicine decoction, the methods of steps (1)-(3) can be adopted, and then the supernatant liquids filtered twice in steps (2) and (3) are combined and can be directly drunk; if it is used as a paste extract dosage form, the composition extract can be obtained by adopting steps (1)-(6) and then further processed; if it is used as tablets, powders, powder agents, etc., the composition dry matter can be obtained by adopting steps (1)-(10a) and then further processed; if it is used as a beverage, the composition beverage can be obtained by adopting steps (1)-(8b) and can be directly drunk.

[0053] In the third aspect of the present invention, there is provided an application of the above-mentioned medicine and food homology composition in the preparation of a drug for treating hyperlipidemia or maintaining the healthy level of blood lipid.

[0054] According to the application of the embodiment of the present invention, it has at least the following beneficial effects: By applying the above-mentioned medicine and food homology composition to the preparation of a drug for treating hyperlipidemia or maintaining the healthy level of blood lipid, it can help maintain the healthy level of blood lipid, avoid the harm caused by increased blood lipid, and has a significant effect of reducing total cholesterol and triglyceride. This application provides a new idea for the current treatment of hyperlipidemia or maintaining the healthy level of blood lipid.

[0055] In the fourth aspect of the present invention, there is provided a traditional Chinese medicine preparation for treating hyperlipidemia or maintaining the healthy level of blood lipid, which contains the above-mentioned medicine and food homology composition.

[0056] The traditional Chinese medicine preparation according to the embodiments of the present invention has at least the following beneficial effects: The effective ingredient of the traditional Chinese medicine preparation provided by the present invention is the above-mentioned medicine and food homologous composition. Starting from the comprehensive conditioning perspectives of promoting blood circulation to remove blood stasis, clearing liver fire, strengthening the spleen and removing dampness, nourishing yin and enriching blood, etc., it can help maintain the healthy level of blood lipids, avoid the harms brought by increased blood lipids, has a significant effect on reducing total cholesterol and triglycerides, helps in the treatment of hyperlipidemia, and has remarkable effects; moreover, it has a mild action, good safety, can be taken for a long time, has a wide range of applicable populations, and has high practical application value.

[0057] In some embodiments of the present invention, the dosage forms of the traditional Chinese medicine preparation include tablets, powders, fine powders, pills, granules, oral liquids, capsules or decoction pastes.

[0058] Specifically, the preparation method of traditional Chinese medicine tablets is as follows: After obtaining the dried composition according to the foregoing steps, the above-mentioned dried composition is mixed evenly with fillers (including but not limited to starch, xylitol, maltitol), sweeteners (including but not limited to mogroside, sucralose, stevioside) and other flavoring agents, and then a wetting agent or binder is used to obtain traditional Chinese medicine granules through granulation, sizing, drying and sieving. The traditional Chinese medicine granules are mixed evenly with lubricants (including but not limited to magnesium stearate, microcrystalline silica) and pressed into tablets using a tableting machine to obtain traditional Chinese medicine tablets.

[0059] Specifically, the preparation method of traditional Chinese medicine granules is as follows: After obtaining the dried composition according to the foregoing steps, the above-mentioned dried composition is mixed evenly with fillers (including but not limited to starch, xylitol, maltitol), sweeteners (including but not limited to mogroside, sucralose, stevioside) and other flavoring agents, and then a wetting agent or binder is used to obtain traditional Chinese medicine granules through granulation, sizing, drying and sieving processes.

[0060] Specifically, the preparation method of traditional Chinese medicine pills is as follows: After obtaining the thick paste of the composition according to the foregoing steps, an appropriate amount of excipients (including but not limited to starch, sugar alcohol, lactose) is added to the above-mentioned thick paste of the composition and mixed to make pills with appropriate hardness and softness; then the wet granules are dried, sieved, polished and coated to obtain traditional Chinese medicine pills.

[0061] Specifically, the preparation method of the Chinese medicine oral liquid is as follows: after obtaining the composition paste according to the above steps, take a predetermined number of portions of the composition paste (calculated by the amount of crude drugs), add an appropriate amount of sweetener (including but not limited to mogroside, sucralose, stevioside), acidulant (including but not limited to citric acid, malic acid, tartaric acid) or other food additives, and then add water to dilute to a predetermined volume, and after filling and sterilization processes, obtain the Chinese medicine oral liquid. For example: if one bottle of oral liquid contains one portion of the formula crude drug, and each bottle of oral liquid is quantitatively 20ml, then take 600 portions of the composition paste (calculated by the amount of crude drugs), add water to dilute to 2000ml, and that's it.

[0062] Specifically, the preparation method of the Chinese medicine paste is as follows: after obtaining the composition paste according to the above steps, take a predetermined number of portions of the composition paste (calculated by the amount of crude drugs), add an appropriate amount of sweetener (including but not limited to honey, fructose syrup, maltitol liquid), acidulant (including but not limited to citric acid, malic acid, tartaric acid) or other food additives, and then add water to dilute to a predetermined dose (for example, 5000g), and after filling and sterilization processes, obtain the Chinese medicine paste. For example: if 1 bottle of paste contains 30 portions of formula crude drugs, and each bottle of paste has a fixed amount of 250g, then take 600 portions of the composition paste (calculated by the amount of crude drugs), and then add water to dilute to 5000g.

[0063] In some embodiments of the present invention, the traditional Chinese medicine preparation further comprises a pharmaceutically acceptable excipient.

[0064] Preferably, the auxiliary materials include at least one of fillers, lubricants, dispersants, wetting agents, adhesives, antioxidants and preservatives.

[0065] The fifth aspect of the present invention provides a product that helps maintain healthy blood lipid levels, comprising the medicine-food composition as described above.

[0066] The product according to the embodiment of the present invention has at least the following beneficial effects: the product provided by the present invention, comprising the above-mentioned medicine and food homologous composition, can help maintain the healthy level of blood lipids, avoid the harm caused by increased blood lipids, and has a significant effect of reducing total cholesterol and triglycerides; and has a mild effect, good safety, can be taken for a long time, and is suitable for a wide range of people. Not only that, its components are all materials that are medicine and food homologous, so it has a better taste, and it is also more convenient to use after being made into food, beverage or granules.

[0067] In some embodiments of the present invention, the product includes food, beverage, or medicinal granules. The present invention does not impose any restrictions on the type of the product. By way of example, the above-mentioned medicated and edible homologous composition can be ground into fine powder, mixed with sucrose, and processed into candies; or ground into fine powder and made into pastries with yam powder as the carrier; or ground into fine powder, mixed with carriers, processed by low-temperature drying, and formed into medicinal granules for daily brewing and drinking; or directly prepared into a beverage according to the foregoing description and directly consumed.

[0068] Specifically, the preparation method of the beverage is as follows: after obtaining the thick paste of the composition according to the foregoing steps, take a predetermined number of portions (calculated by the crude drug amount) of the thick paste of the above composition, add appropriate food additives (sweeteners, flavors and fragrances), food nutritional fortifiers, and new food raw materials, and then add water to dilute to a predetermined volume to prepare a solution; sub-pack the prepared solution, sterilize it at 120 °C for 15 minutes, and cool to obtain the beverage. For example: if calculated by 1 portion of the crude drug amount per bottle of beverage and the fixed quantity of each bottle of beverage is 30 ml, then take 100 portions of the thick paste of the composition (calculated by the crude drug amount), add water to dilute to 3000 ml, and sub-pack the prepared solution at 30 ml / bottle. BRIEF DESCRIPTION OF THE DRAWINGS

[0069] The present invention will be further described below with reference to the drawings and embodiments, where:

[0070] Figure 1 It is a schematic diagram of the triglyceride (TG) level in the serum of rats in each group after the administration ends provided by the embodiment of the present invention;

[0071] Figure 2 It is a schematic diagram of the total cholesterol (TC) level in the serum of rats in each group after the administration ends provided by the embodiment of the present invention;

[0072] Figure 3 It is a schematic diagram of the low-density lipoprotein cholesterol (LDL-C) level in the serum of rats in each group after the administration ends provided by the embodiment of the present invention;

[0073] Figure 4 It is a schematic diagram of the high-density lipoprotein cholesterol (HDL-C) level in the serum of rats in each group after the administration ends provided by the embodiment of the present invention;

[0074] Among them, compared with the normal group, #P < 0.05, ##P < 0.01; compared with the model group, *P < 0.05, **P < 0.01. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0075] The concept of the present invention and the technical effects produced will be clearly and completely described below in conjunction with embodiments to fully understand the purpose, features, and effects of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without creative efforts fall within the scope of protection of the present invention.

[0076] In the description of the present invention, the descriptions referring to terms such as "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" mean that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0077] In the description of the present invention, unless otherwise specified, the numerical range "a~b" represents an abbreviated representation of any real number combination between a and b, where a and b are both real numbers. Unless otherwise specified, each reaction or operation step can be carried out in sequence or not in sequence. Preferably, the reaction method in the present invention is carried out in sequence.

[0078] In the following embodiments, if the specific technology or conditions are not specified, they shall be carried out according to the technology or conditions described in the literature in this field or according to the product specification. All reagents or instruments without indicating the manufacturer can be obtained as conventional products through commercial purchase.

[0079] Example 1 Preparation of a Traditional Chinese Medicine Composition for Maintaining a Healthy Blood Lipid Level

[0080] The weight ratio of each component in the composition of this example is as follows: 5 parts of peach kernels, 5 parts of dried tangerine peel, 2 parts of hawthorn, 2 parts of wolfberries, 1 part of gastrodia elata, 1 part of cassia seeds, 1 part of platycodon grandiflorum, 1 part of poria cocos, 1 part of roasted licorice root, 1 part of the fibrous roots of notoginseng, and 1 part of the flowers of notoginseng.

[0081] (1) Weigh the medicinal materials according to the weight ratio of each component of the composition, pour them into the extraction tank, and then add water with a weight 8 times that of the total weight of the medicinal materials, and soak for 30 minutes.

[0082] (2) Heat the soaked medicinal materials to boiling and extract for 2 hours, filter, and take the supernatant for later use.

[0083] (3) Add water with a weight 8 times that of the medicinal materials after extraction and filtration again, heat to boiling for 2 hours, filter, and take the supernatant.

[0084] (4) Combine the supernatants from the two filtrations in steps (2) and (3), transfer them to an evaporation tank, and heat and concentrate to a specific gravity of approximately 1.10 g / cm3;

[0085] (5) Filter the concentrated liquid from step (4) to remove impurities, and then filter it through a ceramic membrane to collect the filtrate;

[0086] (6) Concentrate the filtrate from step (5) to a thick paste with a specific gravity of 1.25 g / cm3, which is the thick paste of the composition.

[0087] Example 2 Preparation of a Traditional Chinese Medicine Composition for Maintaining a Healthy Blood Lipid Level

[0088] In the composition of this example, the weight ratios of the components are as follows: 36 parts of peach kernels, 40 parts of dried tangerine peel, 30 parts of hawthorn, 28 parts of wolfberries, 25 parts of gastrodia elata, 25 parts of cassia seeds, 25 parts of platycodon grandiflorum, 25 parts of poria cocos, 20 parts of roasted licorice root, 10 parts of fibrous roots of notoginseng, and 10 parts of flowers of notoginseng.

[0089] (1) Weigh the medicinal materials according to the weight ratios of the components of the composition. After pouring them into the extraction tank, add 10 times the total weight of the medicinal materials of water and soak for 60 min;

[0090] (2) Heat the soaked medicinal materials to boiling and extract for 2 hours, filter, and take the supernatant for later use;

[0091] (3) Add 10 times the weight of water to the medicinal materials after extraction and filtration, heat to boiling for 2 hours, filter, and take the supernatant;

[0092] (4) Combine the supernatants from the two filtrations in steps (2) and (3), transfer them to an evaporation tank, and heat and concentrate to a specific gravity of approximately 1.20 g / cm3;

[0093] (5) Filter the concentrated liquid from step (4) to remove impurities, and then filter it through a ceramic membrane to collect the filtrate;

[0094] (6) Concentrate the filtrate from step (5) to a thick paste with a specific gravity of 1.35 g / cm3, which is the thick paste of the composition.

[0095] Example 3 Preparation of a Traditional Chinese Medicine Composition for Maintaining a Healthy Blood Lipid Level

[0096] In the composition of this example, the weight ratios of the components are as follows: 18 parts of peach kernels, 18 parts of dried tangerine peel, 12 parts of hawthorn, 12 parts of wolfberries, 9 parts of gastrodia elata, 9 parts of cassia seeds, 9 parts of platycodon grandiflorum, 9 parts of poria cocos, 6 parts of roasted licorice root, 5 parts of fibrous roots of notoginseng, and 5 parts of flowers of notoginseng.

[0097] (1) Weigh the medicinal materials according to the weight ratios of the components of the composition. After pouring them into the extraction tank, add 9 times the total weight of the medicinal materials of water and soak for 50 min;

[0098] (2) Heat the soaked medicinal materials to boiling and extract for 2 hours, then filter and collect the supernatant for later use.

[0099] (3) Add water with a weight 9 times that of the medicinal materials after extraction and filtration, heat to boiling for 2 hours, filter, and collect the supernatant.

[0100] (4) Combine the supernatants obtained from the two filtrations in steps (2) and (3), transfer them to an evaporation tank, and heat and concentrate to a specific gravity of approximately 1.15 g / cm3.

[0101] (5) Filter the concentrated liquid from step (4) to remove impurities, then filter through a ceramic membrane, and collect the filtrate.

[0102] (6) Concentrate the filtrate from step (5) to a thick paste with a specific gravity of 1.30 g / cm3, which is the thick paste of the composition.

[0103] Example 4 Preparation of a Traditional Chinese Medicine Composition for Maintaining a Healthy Blood Lipid Level

[0104] In the composition of this example, the weight ratios of each component are as follows: 16 parts of peach kernels, 28 parts of dried tangerine peel, 10 parts of hawthorn, 10 parts of wolfberries, 5 parts of gastrodia elata, 6 parts of cassia seeds, 6 parts of platycodon grandiflorum, 5 parts of poria cocos, 7 parts of roasted licorice root, 4 parts of the fibrous roots of notoginseng, and 4 parts of the flowers of notoginseng.

[0105] The preparation method of the thick paste of the composition is the same as that in Example 3.

[0106] Example 5 Preparation of a Traditional Chinese Medicine Composition for Maintaining a Healthy Blood Lipid Level

[0107] In the composition of this example, the weight ratios of each component are as follows: 22 parts of peach kernels, 20 parts of dried tangerine peel, 15 parts of hawthorn, 15 parts of wolfberries, 12 parts of gastrodia elata, 10 parts of cassia seeds, 10 parts of platycodon grandiflorum, 12 parts of poria cocos, 8 parts of roasted licorice root, 6 parts of the fibrous roots of notoginseng, and 6 parts of the flowers of notoginseng.

[0108] The preparation method of the thick paste of the composition is the same as that in Example 3.

[0109] Example 6 Preparation of Tablets of a Traditional Chinese Medicine Composition for Maintaining a Healthy Blood Lipid Level

[0110] (1) Take the thick paste of the composition prepared in Example 1, add the filling adjuvant maltodextrin in a ratio of solid content: filling adjuvant = 1:1, mix, and place in a vacuum drying oven at 60 °C for drying.

[0111] (2) Crush the dried material and pass it through a 100-mesh sieve to obtain the dried composition material.

[0112] (3) Mix the dried composition evenly with a filler (starch) and a sweetener (mogroside), and then use a wetting agent or binder to granulate, size, dry, and screen to obtain traditional Chinese medicine granules. The traditional Chinese medicine granules are mixed evenly with a lubricant (magnesium stearate) and pressed into tablets using a tableting machine to obtain traditional Chinese medicine tablets.

[0113] Example 7 Preparation of a Granule of Traditional Chinese Medicine Composition for Maintaining a Healthy Blood Lipid Level

[0114] (1) Take the thick paste of the composition prepared in Example 2, add a filler adjuvant in a ratio of solid content: filler adjuvant = 1:1, mix, and place in a vacuum drying oven at 60 °C for drying;

[0115] (2) Crush the dried product and pass it through a 100-mesh sieve to obtain the dried composition;

[0116] (3) Mix the dried composition evenly with a filler (starch) and a sweetener (sucralose), and then use a wetting agent or binder to go through the processes of granulating, sizing, drying, and screening to obtain traditional Chinese medicine granules.

[0117] Example 8 Preparation of a Pill of Traditional Chinese Medicine Composition for Maintaining a Healthy Blood Lipid Level

[0118] (1) Take the thick paste of the composition prepared in Example 3 and add an appropriate amount of starch to make pills with appropriate hardness;

[0119] (2) Use a machine to extrude strips and make pills, dry the wet granules, screen, polish, and coat to obtain traditional Chinese medicine pills.

[0120] Example 9 Preparation of an Oral Liquid of Traditional Chinese Medicine for Maintaining a Healthy Blood Lipid Level

[0121] Calculated based on 1 portion of the raw drug amount of the formula per bottle of oral liquid, each bottle of oral liquid is quantitatively 20 ml. Take 100 portions (calculated based on the raw drug amount) of the thick paste of the composition prepared in Example 4, add an appropriate amount of sweetener (sucralose), acidulant (citric acid, malic acid) (the addition dosage complies with national standards), and then add water to dilute to 2000 ml, and go through the processes of filling and sterilization to obtain the oral liquid of traditional Chinese medicine.

[0122] Example 10 Preparation of a Paste of Traditional Chinese Medicine for Maintaining a Healthy Blood Lipid Level

[0123] Calculated based on 30 portions of the raw drug amount of the formula per bottle of paste, each bottle of paste is quantitatively 250 g. Take 600 portions (calculated based on the raw drug amount) of the thick paste of the composition prepared in Example 5, add an appropriate amount of sweetener (honey, high fructose syrup), acidulant (citric acid, malic acid) (the addition dosage complies with national standards), and then add water to dilute to 5000 g, and go through the processes of filling and sterilization to obtain the paste of traditional Chinese medicine.

[0124] Example 11 Preparation of Traditional Chinese Medicine Composition Beverage for Maintaining Healthy Blood Lipid Levels

[0125] (1) Based on the amount of crude drug in one formula dose per bottle of beverage, each bottle of beverage is quantitatively 30 ml. Take 100 parts of the thick paste of the composition prepared in Example 3 (calculated by the amount of crude drug), add appropriate sweeteners, flavoring agents, food nutritional fortifiers, and new food raw materials (the added dosage complies with national standards), and then add water to dilute to 3000 ml to prepare a solution;

[0126] (2) Dispense the prepared solution into bottles at 30 ml / bottle, sterilize at 120 °C for 15 minutes, and cool to obtain the composition beverage.

[0127] Example 12 Preparation of Traditional Chinese Medicine Composition Beverage for Maintaining Healthy Blood Lipid Levels

[0128] (1) Based on the amount of crude drug in 0.5 formula doses per bottle of beverage, each bottle of beverage is quantitatively 30 ml. Take 50 parts of the thick paste of the composition prepared in Example 3 (calculated by the amount of crude drug), add food additives, food nutritional fortifiers, and new food raw materials with the same added amounts as in Example 11, and then add water to dilute to 3000 ml to prepare a solution;

[0129] (2) Dispense the prepared solution into bottles at 30 ml / bottle, sterilize at 120 °C for 15 minutes, and cool to obtain the composition beverage.

[0130] Example 13 Preparation of Traditional Chinese Medicine Composition Beverage for Maintaining Healthy Blood Lipid Levels

[0131] (1) Based on the amount of crude drug in 2 formula doses per bottle of beverage, each bottle of beverage is quantitatively 30 ml. Take 200 parts of the thick paste of the composition prepared in Example 3 (calculated by the amount of crude drug), add food additives, food nutritional fortifiers, and new food raw materials with the same added amounts as in Example 11, and then add water to dilute to 3000 ml to prepare a solution;

[0132] (2) Dispense the prepared solution into bottles at 30 ml / bottle, sterilize at 120 °C for 15 minutes, and cool to obtain the composition beverage.

[0133] Example 14 Evaluation Test Example of the Function of Traditional Chinese Medicine Composition in Helping to Maintain Healthy Blood Lipid Levels

[0134] 1. Principle: Feeding animals with a mixed high-fat diet containing cholesterol, sugar, lard, sodium cholate, etc. can form an animal model of lipid metabolism disorder (mixed hyperlipidemia animal model). Then, giving the test sample to the animals can detect the effect of the test sample on hyperlipidemia and can determine the effect of the test sample on lipid absorption, lipoprotein formation, lipid degradation, or excretion.

[0135] 2. Instruments and reagents: Triglyceride (TG) test kit, total cholesterol (T-CHO) test kit, low-density lipoprotein cholesterol (LDL-C) test kit, and high-density lipoprotein cholesterol (HDL-C) test kit, all purchased from Nanjing Jiancheng Bioengineering Institute.

[0136] BPX-52 type electrothermal constant temperature incubator, produced by Shanghai Boxun Medical Biotechnology Co., Ltd.; 5424R type high-speed refrigerated centrifuge, produced by Eppendorf; Multiskan GO Thermo continuous wavelength microplate reader, produced by Thermo Fisher Scientific, USA. JJ2000 type electronic balance, produced by Shuangjie Testing Instruments Factory in Changshu City, Jiangsu Province; ELGA LA613 ultrapure water machine, produced by ELGA Lab Water / VWS (UK) Ltd, UK.

[0137] 3. Animal selection: SPF-grade SD rats, weighing 180.0 - 220.0 g, purchased from Beijing Huafukang Biotechnology Co., Ltd.

[0138] 4. Model feed: Add 20.0% sucrose, 15.0% lard, 1.2% cholesterol, 0.2% sodium cholate, and appropriate amounts of casein, calcium hydrogen phosphate, stone powder, etc. to the maintenance feed. Except for crude fat, the moisture, crude protein, crude fiber, crude ash, calcium, phosphorus, etc. of the model feed meet the national standards of the maintenance feed. The feed is purchased from Keao Xieli (Tianjin) Feed Co., Ltd.

[0139] 5. Establish a mixed hyperlipidemia animal model

[0140] (1) Modeling period: Select 80 male SPF-grade SD rats, randomly divided into a normal group and a modeling group, with 12 and 68 rats respectively. The normal group is fed with the basal diet, and the modeling group is fed with the mixed hyperlipid diet to establish a model of mixed hyperlipidemia rats. After 14 days of feeding, blood is collected from the medial canthus without fasting, serum is separated, and the concentration of total cholesterol (TC) in the serum of the rats in the modeling group is detected. Rats with too high or too low TC concentration are excluded, and the remaining 60 rats are randomly divided into 5 groups, with 12 rats in each group, for the next experiment. The groups are the model group, the traditional Chinese medicine composition group (low-dose traditional Chinese medicine composition group, medium-dose traditional Chinese medicine composition group, high-dose traditional Chinese medicine composition group), and the atorvastatin calcium tablet group.

[0141] (2) Test period: After grouping, the normal group that was not modeled was used as the blank control and continued to be fed the basal diet, while the modeled groups (including the model group, the groups of the traditional Chinese medicine composition at various doses, and the atorvastatin calcium tablet group) continued to be fed the mixed high-fat diet. At the same time, the corresponding test samples were intragastrically administered to each group: the atorvastatin calcium tablet group was intragastrically administered atorvastatin calcium tablets (purchased commercially) at a dose of 20.0 mg / kg as the positive control; the traditional Chinese medicine composition group was intragastrically administered the traditional Chinese medicine composition obtained in Example 3 (this traditional Chinese medicine composition is denoted as Sanqi Tianma Bazhen Decoction). Among them, the low-dose traditional Chinese medicine composition group was intragastrically administered the traditional Chinese medicine composition obtained in Example 3 at a dose of 1.43 g / kg, the medium-dose traditional Chinese medicine composition group was intragastrically administered the traditional Chinese medicine composition obtained in Example 3 at a dose of 2.86 g / kg, and the high-dose traditional Chinese medicine composition group was intragastrically administered the traditional Chinese medicine composition obtained in Example 3 at a dose of 5.72 g / kg; the normal group and the model group were both intragastrically administered pure water, and the administered volume was 10.0 mL / kg. Each group was intragastrically administered once a day for 30 consecutive days.

[0142] (3) Observation indicators: After the test ended, all rats were sacrificed by abdominal aortic blood collection without fasting, and the serum was separated to detect the levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in the serum of each group.

[0143] (4) Effects on rats with mixed hyperlipidemia model

[0144] The data were processed using SPSS 20.0 statistical software. Measurement data were expressed as mean ± standard deviation (±s). One-way ANOVA was used for comparison among multiple groups, and LSD test was used for pairwise comparison among multiple groups. A P value < 0.05 was considered statistically significant.

[0145] The results are shown in Table 1 and Figures 1-4 as follows, where "Sanqi Tianma Bazhen Decoction" refers to each group intragastrically administered the traditional Chinese medicine composition obtained in Example 3.

[0146]

[0147] Note: Compared with the normal group, #P < 0.05, ##P < 0.01; compared with the model group, *P < 0.05, **P < 0.01.

[0148] The results showed that, compared with the normal group, after SPF-grade SD male rats were fed with the mixed high-fat diet, the TC concentration in the rats increased significantly and was suitable for the experiment (P<0.01). After the experiment, compared with the normal group, the concentrations of TC, TG, LDL-C and HDL-C in the model group changed significantly (P<0.05 or 0.01); compared with the model group, the TG concentrations in each dose group administered with the traditional Chinese medicine composition in Example 3 of the present invention decreased significantly, and the HDL-C concentration increased significantly (P<0.05 or 0.01), showing a dose-dependence, and the TC and LDL-C concentrations did not change significantly (P>0.05).

[0149] In summary, the composition of the present invention has the effect of improving the blood lipid level of rats in the animal model of mixed hyperlipidemia, indicating that the composition of the present invention helps to maintain the healthy level of blood lipids (cholesterol / triglyceride).

[0150] Example 15 Human trial example of the composition beverage for helping to maintain the healthy level of blood lipids

[0151] In this example, a human trial of the composition beverage was carried out, and the process of the trial obtained the informed consent of the subjects and complied with the relevant regulations. The test method is as follows:

[0152] 1. Subject selection: The subjects were of either sex, were simple dyslipidemic people, 10 in number, and maintained a normal diet.

[0153] 2. Test method: The test group took the composition beverage obtained in Example 11 of the present invention. The taking method was 2 times a day, 1 bottle each time, and it was taken continuously for 2 phases (28 days, 14 days for each phase). The blood biochemical indexes were detected on the last day of each phase. During the test, the original living and eating habits were not changed, and a normal diet was maintained.

[0154] 3. Observation indexes

[0155] (1) General situation inquiry: The mental state, sleep and diet of the test subjects before and after the trial were inquired. It was found that the general situation of the test subjects was good before and after the trial, and there were no obvious abnormalities in the mental state, sleep and diet.

[0156] (2) Determination of biochemical indexes: The contents of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were detected on the last day of each phase. The results are shown in Table 2.

[0157]

[0158] Among them, the normal reference values of the four blood lipid indicators are as follows: TC: 0 - 5.60 mmol / L; TG: 0 - 2.30 mmol / L; LDL-C: 0 - 4.11 mmol / L; HDL-C, for men > 0.9 mmol / L, for women > 1.15 mmol / L.

[0159] As can be seen from Table 2, for serum total cholesterol (TC): the number of abnormal people before the trial diet was 9, the number of abnormal people after the first-stage trial diet was 5, and the number of abnormal people after the second-stage trial diet was 3.

[0160] For triglyceride (TG): the number of abnormal people before the trial diet was 6, the number of abnormal people after the first-stage trial diet was 0, and the number of abnormal people after the second-stage trial diet was 0.

[0161] For low-density lipoprotein cholesterol (LDL-C): the number of abnormal people before the trial diet was 2, the number of abnormal people after the first-stage trial diet was 3, and the number of abnormal people after the second-stage trial diet was 1.

[0162] For high-density lipoprotein cholesterol (HDL-C): the number of abnormal people before the trial diet was 2, the number of abnormal people after the first-stage trial diet was 3, and the number of abnormal people after the second-stage trial diet was 2.

[0163] As can be seen from the above, during the continuous administration of the composition beverage of the present invention by the subjects, there were no obvious changes in spirit, sleep, and diet, and no other adverse reactions were observed. It shows that this product has no adverse effects on the health of the subjects during the trial diet. After four weeks of the volunteer trial diet, the number of subjects with abnormal total cholesterol (TC) index decreased from 9 to 3, all 6 subjects with abnormal triglyceride (TG) index returned to normal, and the number of subjects with abnormal low-density lipoprotein cholesterol (LDL-C) decreased from 2 to 1.

[0164] In summary, the composition beverage of the present invention helps to maintain the healthy level of blood lipids (total cholesterol / triglyceride), and the present invention has a reasonable compatibility. It is a raw material of medicine and food homology, has no adverse reactions, and can be used for a long time.

[0165] The above-described embodiments only represent several implementation manners of the present invention. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the patent of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several deformations and improvements can still be made, and these all belong to the protection scope of the present invention.

Claims

1. A medicine and food homology composition, characterized in that, Comprising the following components in parts by weight: 5 - 36 parts of peach kernels, 5 - 40 parts of dried tangerine peel, 2 - 30 parts of hawthorn, 2 - 28 parts of wolfberry fruits, 1 - 25 parts of gastrodia elata, 1 - 25 parts of cassia seeds, 1 - 25 parts of platycodon grandiflorum, 1 - 25 parts of poria cocos, 1 - 20 parts of roasted licorice root, 1 - 10 parts of fibrous roots of notoginseng, 1 - 10 parts of flowers of notoginseng.

2. The homologous medicine and food composition according to claim 1, wherein The medicated and edible homologous composition comprises the following components in parts by weight: 18 - 36 parts of peach kernels, 18 - 40 parts of dried tangerine peel, 12 - 30 parts of hawthorn, 12 - 28 parts of wolfberry fruits, 9 - 25 parts of gastrodia elata, 9 - 25 parts of cassia seeds, 9 - 25 parts of platycodon grandiflorum, 9 - 25 parts of poria cocos, 6 - 20 parts of roasted licorice root, 5 - 10 parts of fibrous roots of notoginseng, 5 - 10 parts of flowers of notoginseng.

3. The homologous medicine and food composition according to claim 2, characterized in that, The medicated and edible homologous composition comprises the following components in parts by weight: 18 parts of peach kernels, 18 parts of dried tangerine peel, 12 parts of hawthorn, 12 parts of wolfberry fruits, 9 parts of gastrodia elata, 9 parts of cassia seeds, 9 parts of platycodon grandiflorum, 9 parts of poria cocos, 6 parts of roasted licorice root, 5 parts of fibrous roots of notoginseng, 5 parts of flowers of notoginseng.

4. A preparation method of the medicine and food homologous composition according to any one of claims 1-3, characterized in that, Including the steps: weighing the medicinal materials of each component according to the weight ratio, soaking in water for 30 - 60 min, decocting 2 - 3 times, combining the medicinal liquids obtained from multiple decoctions, and concentrating the medicinal liquid to obtain a thick paste of the composition.

5. The preparation method according to claim 4, characterized in that, After obtaining the thick paste of the composition, it further includes the steps: detecting the solid content of the thick paste of the composition, adding the same weight of filling adjuvants according to its solid content for mixing, and subjecting the obtained mixture to vacuum drying to obtain a dried product of the composition.

6. Use of the medicated and edible homologous composition according to any one of claims 1 - 3 in the preparation of a drug for treating hyperlipidemia or maintaining the healthy level of blood lipid.

7. A traditional Chinese medicine preparation for treating hyperlipidemia or maintaining a healthy blood lipid level, characterized in that, The traditional Chinese medicine preparation contains the medicated and edible homologous composition according to any one of claims 1 - 3.

8. The traditional Chinese medicine preparation according to claim 7, characterized in that, The dosage form of the traditional Chinese medicine preparation includes decoction, tablets, powder, powder, pills, granules, oral liquid, capsules or paste.

9. A product that helps maintain a healthy level of blood lipids, characterized in that, The product contains the medicated and edible homologous composition according to any one of claims 1 - 3.

10. The product according to claim 9, wherein, The product includes food, beverage, or instant powder.

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