A hangover-relieving and liver-protecting composition and its application

Abstract

The present invention relates to the field of Chinese medicine compositions, and in particular to a hangover-relieving and liver-protecting composition and its application. The hangover-relieving and liver-protecting composition of the present invention comprises the following raw materials: 1-4 parts of artificial bezoar, 1-4 parts of artificial bear bile, 35-55 parts of Panax notoginseng extract, 40-60 parts of Artemisia capillaris extract, 50-70 parts of Smilax glabra extract, 30-50 parts of Polygonum cuspidatum extract, 30-50 parts of white peony extract, 70-90 parts of Pueraria lobata extract, 40-60 parts of Polygonatum sibiricum extract, 40-60 parts of malt extract, and 25-35 parts of Amomum villosum extract. The hangover-relieving and liver-protecting composition of the present invention has similar effects on relieving the weight loss of rats caused by an acute drunkenness model, the sobering rate within 6 hours, liver protection, and antioxidant effects as the positive drug Neptune's Golden Bottle, and is better in terms of weight improvement effect, sobering rate, and improving the body's antioxidant capacity, and has good development and application value.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine compositions, and in particular to a hangover-relieving and liver-protecting composition and its application. Background Art

[0002] Current research focuses on accelerating alcohol metabolism by activating alcohol dehydrogenase and acetaldehyde dehydrogenase. For example, puerarin in kudzu root extract can reduce the peak blood ethanol concentration (by 40%) by delaying gastric emptying, but it cannot reduce the total alcohol intake. In addition, existing alcohol detoxification products (such as kudzu root preparations) can only delay alcohol absorption, but cannot increase the activity of acetaldehyde dehydrogenase, and have no direct intervention effect on acetaldehyde toxicity. Although some products accelerate alcohol excretion by adding diuretics, it will increase the burden on the kidneys and cause electrolyte imbalance.

[0003] Furthermore, alcohol metabolism involves damage to multiple organs, including the liver, stomach, and brain. Existing products often focus on liver protection or symptom relief, neglecting the synergistic intervention of intestinal flora imbalance (such as alcohol-induced leaky gut) and neuroinflammation. Furthermore, traditional decoctions have low concentrations of active ingredients, while novel delivery systems like nanohydrogels are still in the experimental stage, making industrial production difficult. Summary of the Invention

[0004] In view of this, the present invention discloses a hangover-relieving and liver-protecting composition, which solves the problems existing in the prior art such as insufficient metabolic efficiency, single-target limitations and side effects, lack of multi-organ synergistic protection, dosage form and bioavailability.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] The present invention discloses a composition for sobering up and protecting the liver, comprising the following raw materials:

[0007] 1-4 parts of artificial bezoar, 1-4 parts of artificial bear bile, 35-55 parts of Panax notoginseng extract, 40-60 parts of Artemisia capillaris extract, 50-70 parts of Smilax glabra extract, 30-50 parts of Polygonum cuspidatum extract, 30-50 parts of White Peony Root extract, 70-90 parts of Pueraria lobata flower extract, 40-60 parts of Polygonatum sibiricum extract, 40-60 parts of malt extract, and 25-35 parts of Amomum villosum extract.

[0008] Optionally, the alcohol-relieving and liver-protecting composition comprises the following raw materials:

[0009] 2.5 parts of artificial bezoar, 2.5 parts of artificial bear bile, 45 parts of Panax notoginseng extract, 50 parts of Artemisia capillaris extract, 60 parts of Smilax glabra extract, 40 parts of Polygonum cuspidatum extract, 40 parts of White Peony Root extract, 80 parts of Pueraria lobata extract, 50 parts of Polygonatum sibiricum extract, 50 parts of malt extract, and 30 parts of Amomum villosum extract.

[0010] It should be noted that the principles and effects of the technical solution of the present invention are as follows:

[0011] Main Herb (Core Medicinal Effect): Kudzu Flower Extract, a traditional alcohol detoxifier, is described in the Compendium of Materia Medica as "detoxifying alcohol, invigorating the spleen and soothing the stomach." Modern research shows it can accelerate ethanol metabolism, inhibit alcohol absorption, and reduce blood alcohol concentration. Panax Notoginseng Extract promotes blood circulation, removes blood stasis, protects the liver, and reduces enzyme levels, improving microcirculatory disorders caused by alcoholic liver damage and promoting liver cell repair. Significance of the Combination: Kudzu Flower detoxifies alcohol as a primary remedy, while Panax Notoginseng protects the liver as a primary remedy. Together, these two main herbs embody the dual "alcohol detoxification and liver protection" strategy. Secondary Herb (Synergistic Effect): Artemisia Capillaris Extract clears damp-heat in the liver and gallbladder, promotes bile excretion, accelerates the metabolism of fat-soluble toxins, and improves alcoholic jaundice. Polygonum cuspidatum Extract clears heat and detoxifies, and its resveratrol inhibits ethanol-induced oxidative stress, synergistically enhancing its detoxifying properties with Artemisia Capillaris. White Peony Root Extract softens the liver and relieves pain, alleviating liver distension and pain after alcohol consumption. The paeoniflorin it contains has anti-inflammatory and hepatoprotective properties. Compatibility: The three herbs form a synergistic chain of "clearing heat and dampness, detoxifying and combating inflammation, and softening the liver and alleviating pain." Adjuvant (auxiliary conditioning): Smilax glabra extract detoxifies and eliminates dampness, targeting the toxicity of acetaldehyde, a metabolite of alcohol, and alleviating hangover headaches. Polygonatum sibiricum extract nourishes both Qi and Yin, improving liver and kidney Yin deficiency caused by chronic alcohol consumption and regulating immune function. Artificial bezoar and artificial bear bile, combined in trace amounts, clear the heart and cool the liver, inhibiting alcohol-induced nervous excitement and hyperactive liver fire. Roasted malt extract promotes digestion and soothes the stomach, alleviating poor appetite and abdominal distension after drinking. Its amylase content promotes digestion. Special features: Combining cooling and warming effects (bezoar / bear bile combined with Polygonatum sibiricum), and combining attacking and tonifying effects (Smilax glabra combined with Polygonatum sibiricum). Guiding herb (harmony and guiding the meridians): Amomum villosum extract promotes Qi and dampness, invigorates the spleen and stimulates appetite, guiding all herbs to the middle jiao spleen and stomach, and alleviating nausea and vomiting after drinking. Key point: Amomum villosum's aromatic and penetrating properties penetrate greasy food and alcohol, enhancing the overall bioavailability of the formula.

[0012] Furthermore, the key issues and innovations of the present invention's formulation technology are as follows:

[0013] 1) Multi-target metabolic synergy

[0014] Acetaldehyde toxicity control: The formula contains kudzu flower (which promotes ADH activity) and knotweed (which contains resveratrol to inhibit oxidative stress) to accelerate the conversion of ethanol → acetaldehyde → acetic acid and reduce acetaldehyde accumulation.

[0015] Activation of multiple enzyme systems: Panax notoginseng improves liver microcirculation and enhances ALDH expression efficiency; white peony extract assists detoxification by regulating the cytochrome P450 enzyme system.

[0016] 2) Organ protection network construction

[0017] Integration of the liver-gut-brain axis: Artemisia capillaris extract promotes bile excretion and reduces intestinal toxin absorption; Polygonatum sibiricum polysaccharide regulates intestinal flora; artificial bezoar inhibits alcoholic nerve excitation and forms cross-organ protection.

[0018] Antioxidant and anti-inflammatory synergy: Polygonum cuspidatum and Smilax glabra extracts enhance antioxidant capacity through the Nrf2 / ARE pathway and reduce the apoptosis rate of hepatocytes.

[0019] 3) Dosage form and ingredient optimization

[0020] Standardization of extracts: Modern extraction technology (such as supercritical CO2 extraction) is used to increase the concentration of active ingredients such as kudzuvine root extract and notoginseng saponin, overcoming the low efficiency of traditional decoction methods.

[0021] Sustained-release delivery system: Drawing on the idea of ​​β-lactoglobulin nanogel, we explore the encapsulation technology of Amomum villosum volatile oil to prolong the duration of drug efficacy.

[0022] 4) Improved security

[0023] Control of toxic components: A small amount of artificial bear bile combined with Polygonatum sibiricum neutralizes the coldness through the "adjuvant drug" mechanism, avoiding the risk of diarrhea caused by excessive use of bezoar in traditional hangover prescriptions.

[0024] The present invention also discloses an application of the alcohol-relieving and liver-protecting composition in a pharmaceutical preparation.

[0025] Furthermore, the alcohol-detoxifying and liver-protecting composition is used in the preparation of alcohol-detoxifying and liver-protecting drugs.

[0026] Specifically, the preparation method of the alcohol-relieving and liver-protecting medicine is as follows:

[0027] Artificial bezoar and artificial bear bile were crushed for later use; 875g of Panax notoginseng was coarsely crushed and added with other eight medicinal materials (975g of Artemisia capillaris, 1170g of Smilax glabra, 780g of Polygonum cuspidatum, 780g of White Peony Root, 1560g of Pueraria lobata, 975g of Polygonatum sibiricum, 975g of scorched malt, and 585g of Amomum villosum), decocted twice with water, the first time adding 20 times the amount and decocting for 2 hours, the second time adding 20 times the amount and decocting for 1.5 hours, filtered, combined the decoctions, concentrated under reduced pressure to a clear paste with a relative density of 1.05-1.10 (60°C), centrifuged, and the centrifuge was concentrated under reduced pressure to a thick paste with a relative density of about 1.25 (60°C), and vacuum dried (60-70°C) to obtain 1.8kg of dry paste. After the dry paste is crushed, 14.82g of artificial bezoar, 14.82g of artificial bear bile, and about 770g of microcrystalline cellulose are added, mixed and granulated, the whole granules are dried, and 13g of magnesium stearate is added, mixed, tableted, and coated to make about 5000 tablets.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] The hangover-relieving and liver-protecting composition of the present invention has similar effects on alleviating the weight loss of rats caused by an acute drunkenness model, sobering up within 6 hours, protecting the liver and anti-oxidation as the positive drug Neptune Jinzun, and is better in improving the weight, sobering up and enhancing the body's antioxidant capacity, and has good development and application value. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are merely embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying any creative work.

[0031] Figure 1 is the change in body weight of rats during the experimental period.

[0032] Figure 2 It is the sobering rate of rats in each group within 6 hours after oral administration of liquor.

[0033] Figure 3 Figure 3 is the liver organ index (A) and tissue morphology (B) of rats in each group.

[0034] Figure 4 It is the ALT and AST content in rat serum.

[0035] Figure 5 It is the antioxidant index level in rat serum. DETAILED DESCRIPTION

[0036] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0037] The term "embodiment" is used herein specifically to describe any embodiment as "exemplary," and should not be construed as superior or preferable to other embodiments. Performance indicators in the embodiments of this application were tested using conventional testing methods in the art, unless otherwise specified. It should be understood that the terms used in this application are intended solely to describe specific implementations and are not intended to limit the disclosure herein.

[0038] Unless otherwise specified, the technical and scientific terms used herein have the same meanings as commonly understood by ordinary technicians in the technical field to which this application belongs; other experimental methods and technical means not specifically specified in this application refer to experimental methods and technical means commonly used by ordinary technicians in this field.

[0039] In order to better illustrate the content of this application, numerous specific details are provided in the specific examples below. It should be understood by those skilled in the art that this application can be implemented without certain specific details. In the examples, some methods, means, instruments, equipment, etc. well known to those skilled in the art are not described in detail in order to highlight the main purpose of this application.

[0040] Under the premise of no conflict, the technical features disclosed in the embodiments of this application can be combined arbitrarily, and the resulting technical solutions belong to the contents disclosed in the embodiments of this application.

[0041] The invention discloses a hangover-relieving and liver-protecting composition and its application.

[0042] For a better understanding of the present invention, the present invention is further specifically described below through the following examples, but it should not be understood as limiting the present invention. Some non-essential improvements and adjustments made by those skilled in the art based on the above invention content are also considered to fall within the scope of protection of the present invention.

[0043] Example 1

[0044] A drug (Qiongjiangzunlu tablets) prepared from a hangover-relieving and liver-protecting composition, the main ingredients and contents of each tablet are:

[0045] Artificial bezoar 2.5mg, artificial bear bile 2.5mg, Panax notoginseng 45mg, Artemisia capillaris extract 50mg, Smilax glabra extract 60mg, Polygonum cuspidatum extract 40mg, White Peony root extract 40mg, Pueraria lobata flower extract 80mg, Polygonatum sibiricum extract 50mg, malt extract 50mg, Amomum villosum extract 30mg.

[0046] Preparation process: artificial bezoar and artificial bear bile are crushed for later use; 875g of Panax notoginseng is coarsely crushed and mixed with other eight medicinal materials (975g of Artemisia capillaris, 1170g of Smilax glabra, 780g of Polygonum cuspidatum, 780g of white peony root, 1560g of Pueraria lobata, 975g of Polygonatum sibiricum, 975g of scorched malt, 585g of Amomum villosum), decocted twice with water, the first time adding 20 times the amount and decocting for 2 hours, the second time adding 20 times the amount and decocting for 1.5 hours, filtered, combined the decoction, concentrated under reduced pressure to a clear paste with a relative density of 1.05-1.10 (60°C), centrifuged, and the centrifuge was concentrated under reduced pressure to a thick paste with a relative density of about 1.25 (60°C), and vacuum dried (60-70°C) to obtain 1.8kg of dry paste. After the dry paste is crushed, 14.82g of artificial bezoar, 14.82g of artificial bear bile, and about 770g of microcrystalline cellulose are added, mixed and granulated, the whole granules are dried, and 13g of magnesium stearate is added, mixed, tableted, and coated to make about 5000 tablets.

[0047] In order to further demonstrate the beneficial effects of the present invention and to better understand the present invention, the present invention aims to study the effects of the Qiongjiangzunlu tablets prepared in Example 1 on the drunken behavior and liver function of rats by applying them to a rat drunken model.

[0048] 1. Test method

[0049] Twenty-four SPF male SD rats weighing 250-270 g were used. The rats were randomly divided into 4 groups, with 6 rats in each group, and each group had 1 replicate. They were control group, model group, Qiongjiangzunlu tablet test group (500 mg / tablet) and positive drug control group (Neptune Golden Tablet (1000 mg / tablet) (Weishijianzi (2002) No. 0396)). The control group was gavaged with an equal volume of normal saline, and the other rats were gavaged with 56% liquor (Red Star 56° liquor, 1 mL / 100 g / d) every day to establish an acute drunkenness model. Liquor was gavaged 20 minutes after administration every day, and the experimental period was 14 days. The experimental groups and treatments are detailed in Table 1. The drug dosage is calculated based on the daily adult dosage and the body surface area (rat dosage = human dosage × (37 kg / m 2 ÷6kg / m 2 )).

[0050] Table 1 Experimental groups and treatments

[0051]

[0052] 2. Measurement indicators

[0053] After oral administration of liquor every day, the sobering rate (righting reflex) within 6 hours was observed and recorded to evaluate the sobering effect; body weight changes; liver organ index; liver tissue morphology; serum liver function indexes and antioxidant indexes.

[0054] 3. Test results

[0055] 1. Changes in body mass

[0056] Depend on Figure 1 It can be seen that both Qiongjiangzunlu tablets and positive drugs can effectively alleviate the weight loss of rats caused by acute drunkenness model (P < 0.05), and the Qiongjiangzunlu tablets test group is slightly better than the positive drug group (P > 0.05).

[0057] Table 2 Changes in body weight of rats (g)

[0058]

[0059]

[0060] *For the same experiment data, different letters indicate significant differences between the groups (P<0.05), while the same or no letters indicate no significant differences between the groups (P>0.05).

[0061] 2. Sobering rate of rats within 6 hours after oral administration of liquor

[0062] Depend on Figure 2 It can be seen that the sobering rates of rats in the Qiongjiangzunlu tablets test group and the positive drug group within 6 hours after oral administration of white wine were significantly higher than those in the model group (P < 0.05), and the Qiongjiangzunlu tablets test group was better than the positive drug group (P < 0.05).

[0063] Table 3 Sobering rate of rats within 6 hours after oral administration of liquor (%)

[0064]

[0065] 3. Liver Organ Index and Tissue Morphology

[0066] Depend on Figure 3 It can be seen that the liver organ indexes of rats in the control group, Qiongjiangzunlu tablets test group and positive drug group were significantly lower than those in the model group (P < 0.05); through liver tissue sections, it can be seen that a large number of vacuoles and structural abnormalities appeared in the liver cells of the model group, which were significantly alleviated in the Qiongjiangzunlu tablets test group and positive drug group.

[0067] Table 4 Rat liver organ index %

[0068]

[0069] 4. Serum biochemical and antioxidant indicators

[0070] Depend on Figure 4 It can be seen that the serum alanine aminotransferase (ALT) level of rats in the Qiongjiangzunlu Tablets test group and the positive drug group was significantly lower than that in the model group (P < 0.05), and the serum aspartate aminotransferase (AST) level of rats in the Qiongjiangzunlu Tablets test group was significantly lower than that in the model group and the positive drug group (P < 0.05). Figure 5 It can be seen that the total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) levels of the serum of rats in the Qiongjiangzunlu tablets test group and the positive drug group were significantly higher than those in the model group (P < 0.05), and the GSH-Px level in the serum of rats in the Qiongjiangzunlu tablets test group was significantly higher than that in the positive drug group (P < 0.05); the malondialdehyde (MDA) content in the serum of rats in the Qiongjiangzunlu tablets test group was significantly lower than that in the model group (P < 0.05).

[0071] Table 5 Biochemical and antioxidant indicators in rat serum

[0072]

[0073] Based on the above analysis, it can be seen that the effects of Qiongjiangzunlu tablets on alleviating the weight loss of rats caused by acute drunkenness model, sobering rate within 6 hours, liver protection and antioxidant are similar to those of the positive drug Haiwang Jinzun, and are better in improving body weight, sobering rate and enhancing the body's antioxidant capacity, and have good development and application value.

[0074] The above description of the disclosed embodiments is intended to enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A traditional Chinese medicine composition for relieving alcohol and protecting the liver, characterized in that: Made from the following raw materials in parts by mass: 1-4 parts of artificial bezoar, 1-4 parts of artificial bear bile, 35-55 parts of Panax notoginseng extract, 40-60 parts of Artemisia capillaris extract, 50-70 parts of Smilax glabra extract, 30-50 parts of Polygonum cuspidatum extract, 30-50 parts of White Peony Root extract, 70-90 parts of Pueraria lobata flower extract, 40-60 parts of Polygonatum sibiricum extract, 40-60 parts of malt extract, and 25-35 parts of Amomum villosum extract.

2. The alcohol-relieving and liver-protecting Chinese medicine composition according to claim 1, characterized in that: Made from the following raw materials in parts by mass: 2.5 parts of artificial bezoar, 2.5 parts of artificial bear bile, 45 parts of Panax notoginseng extract, 50 parts of Artemisia capillaris extract, 60 parts of Smilax glabra extract, 40 parts of Polygonum cuspidatum extract, 40 parts of White Peony Root extract, 80 parts of Pueraria lobata extract, 50 parts of Polygonatum sibiricum extract, 50 parts of malt extract, and 30 parts of Amomum villosum extract.

3. Use of the traditional Chinese medicine composition according to claim 1 or 2 in the preparation of alcohol-relieving and liver-protecting drugs.

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