Harness-pluggable fnirs system capable of being used in MRI (Magnetic Resonance Imaging) scene

Abstract

The invention provides an fnirs system which has a pluggable wire harness and can be used in an MRI (Magnetic Resonance Imaging) scene. The fnirs system comprises a host comprising a set of APD devices, a host processor and processing circuitry, a first fiber optic bundle interface, a second fiber optic bundle interface or a second wire interface, and a communication interface, each APD device being respectively configured to be connected to a corresponding D probe on a headgear via a first fiber optic bundle; the main processor and the processing circuit are configured to be electrically connected to a group of APD devices so as to process the electric signals to obtain fnirs detection data; the first optical fiber bundle interface is configured to be detachably plugged with a first optical fiber bundle group joint; and the second optical fiber bundle interface or the second wire interface is configured to be detachably plugged with a second optical fiber bundle group joint or a second wire bundle group joint. Therefore, the optical fiber bundle or the second electric wire can be conveniently mounted and dismounted on the host, the plugging accuracy is remarkably improved, and the accuracy of a detection result is improved.

Description

Technical Field

[0001] This application relates to the field of near-infrared brain functional imaging technology, and particularly relates to a fnirs system with pluggable wiring harness and applicable to MRI imaging scenarios. Background Art

[0002] Near-infrared brain functional imaging (fnirs) devices and magnetic resonance imaging (MRI) devices are two brain imaging technologies with different physical principles. Combining the two modalities of MRI and fnirs for diagnosis and evaluation of brain function status can simultaneously obtain the structural and functional information of the brain, clarify the anatomical structure details of the brain, understand its functional activity status, and help to more comprehensively and accurately evaluate brain function.

[0003] However, ferromagnetic materials are not allowed to be built into the MRI scanning room. Currently, it is impossible to reasonably place fnirs devices in the radiology MRI scanning room. Devices such as the main unit and the upper computer can only be placed outside the scanning room, for example, in the control room or workstation. This results in the optical fibers or wires on the headcap worn by the subject needing to pass through the waveguide holes on the wall to connect to the main unit outside the scanning room, and the length of this optical fiber or wire is 5 to 10 meters. Due to the long length of the optical fiber, it not only causes significant light attenuation, but also is prone to breakage during dragging due to its own weight. In the case where the subject needs to cooperate with the EEG (electroencephalogram) and PET (positron emission tomography) modalities, the subject may also need to remove the optical fibers or wires corresponding to each probe in the scanning room before injecting the drug, and then return to the scanning room after the injection to reinstall the optical fibers or wires on each probe one by one, and then continue to debug the probes and detect fnirs signals. During this process, the disassembly and insertion of the optical fibers or wires are inconvenient, and due to the large number of probes, it is easy to cause incorrect insertion when installing the optical fibers or wires on each probe one by one, affecting the detection results of the fnirs device. Summary of the Invention

[0004] In view of the above technical problems existing in the prior art, this application is proposed. The purpose of this application is to provide a fnirs system with pluggable wiring harness and applicable to MRI imaging scenarios, which can arrange a complete set of fnirs systems including the headcap, SD probe group, and main unit in the MRI scanning room to achieve the synchronous combination of the two modalities of MRI and fnirs, and can conveniently disassemble and insert the optical fibers or wires connected to the probes on the headcap on the main unit, facilitating the movement of the headcap wearer in and out of the scanning room, ensuring the correct rate of insertion, and improving the accuracy of the detection results.

[0005] According to a first aspect of the present application, there is provided an fnirs system with a pluggable wire harness and applicable to MRI imaging scenarios. The fnirs system includes a headcap, an SD probe set configured on the headcap, and a host. Among them, the S probe is used to transmit near-infrared light to the subject, and the D probe is used to receive near-infrared light from the subject. Neither the headcap nor the SD probe set contains ferromagnetic materials, so that they can be placed in the scanning hole of the MRI imaging system. The S probe is connected to a second fiber bundle or a second electric wire, and the D probe is connected to a first fiber bundle; the host is encapsulated in a shielding housing to be placed within a predetermined space range around the isocenter in the scanning hole of the MRI imaging system. The shielding housing is made of a first non-ferromagnetic metal; the host specifically includes a set of APD devices, a main processor and a processing circuit, a first fiber bundle interface, a second fiber bundle interface or a second electric wire interface, and a communication interface. Among them, each APD device is respectively configured to be connected to the corresponding D probe on the headcap via the first fiber bundle to receive the near-infrared light emitted from the subject's head and convert it into an electrical signal; the main processor and the processing circuit are configured to be electrically connected to the set of APD devices to process the electrical signal to obtain fnirs detection data; the first fiber bundle interface is configured to detachably plug in a first fiber bundle group joint formed by the first fiber bundles; the second fiber bundle interface or the second electric wire interface is configured to detachably plug in a second fiber bundle group joint formed by the second fiber bundles or a second electric wire bundle group joint formed by the second electric wires; and the communication interface is configured to be connected to a host computer via a communication path to transmit fnirs detection data thereto without introducing ferromagnetic materials.

[0006] Compared with the prior art, the beneficial effects of the embodiments of the present application are as follows: The wire harness provided by the embodiment of the present application is pluggable and can be used in an fnirs system under an MRI imaging scenario. Its headcap and SD probe set do not contain ferromagnetic materials, and the host is also encapsulated in a shielding housing, so that a complete set of fnirs system including the headcap, SD probe set and host is arranged in the MRI scanning room to achieve synchronous combination of the two modalities of MRI and fnirs. Placing the host in the scanning hole can shorten the length of the optical fiber or wire between the probe on the headcap worn by the subject and the host. Moreover, by setting a first optical fiber bundle interface, a second optical fiber bundle interface or a second wire interface on the host, it is convenient to plug or detach the first optical fiber bundle group connector, the second optical fiber bundle group connector or the second wire bundle group connector from the host, significantly improving the convenience of disassembly and plugging, and improving the correct rate of plugging the optical fiber or the second wire on the host, which is beneficial to improving the accuracy of the detection result. Among them, a communication interface is also set on the host, which can realize placing the host in the scanning hole and connecting it to the upper computer outside the scanning room through the communication interface on the host. In this way, the subject can conveniently move around with the first optical fiber bundle, the second optical fiber bundle or the second wire and the host. Or, the position of the host in the scanning room can be kept fixed, and by unplugging the first optical fiber bundle group connector, the second optical fiber bundle group connector or the second wire bundle group connector from the host, it is convenient for the subject to drag the shorter optical fiber or the second wire in and out of the scanning room.

[0007] The above description is only an overview of the technical solution of the present application. In order to be able to understand the technical means of the present application more clearly, it can be implemented according to the content of the specification. And in order to make the above description and other purposes, features and advantages of the present application more obvious and understandable, the following specifically gives the specific implementation manners of the present application. Brief Description of the Drawings

[0008] In the drawings that are not necessarily drawn to scale, the same reference numerals can describe similar components in different views. Similar reference numerals with alphabetic suffixes or different alphabetic suffixes can represent different examples of similar components. The drawings generally illustrate various embodiments by way of example and not limitation, and are used together with the specification and the claims to explain the disclosed embodiments. Such embodiments are illustrative and exemplary and are not intended to be an exhaustive or exclusive embodiment of the method, apparatus, system or non-transitory computer-readable medium having instructions for implementing the method.

[0009] Figure 1 Fig. shows a schematic diagram of a wire harness that is pluggable and can be used in an fnirs system under an MRI imaging scenario according to an embodiment of the present application.

[0010] Figure 2 Fig. shows a schematic structural diagram of a host according to an embodiment of the present application.

[0011] Figure 3 Shows a schematic diagram of the interfaces, the first optical fiber bundle connector, and the second wire harness group connector on the host according to an embodiment of the present application.

[0012] Figure 4 Shows a schematic diagram of the spatial variation of the gradient magnetic field in an MRI imaging system according to an embodiment of the present application.

[0013] Figure 5 Shows a schematic diagram of providing a support platform within a predetermined peripheral space range of the isocenter in the scanning hole to place related devices such as an electroencephalogram amplifier used in conjunction with an MRI system.

[0014] Figure 6 Shows a schematic diagram of the structure of the first mounting bracket inside the host according to an embodiment of the present application. Detailed implementation manners

[0015] To enable those skilled in the art to better understand the technical solutions of the present application, the present application will be described in detail below with reference to the accompanying drawings and specific implementation manners. The embodiments of the present application will be further described in detail below with reference to the accompanying drawings and specific examples, but this is not a limitation to the present application.

[0016] The "first", "second", and similar terms used in the present application do not represent any order, quantity, or importance, but are only used for distinction and convenience in expression, and do not strongly limit that "first" and "second" must be different. For example, the "first non-ferromagnetic metal", "second non-ferromagnetic metal", and "third non-ferromagnetic metal" may be the same non-ferromagnetic metal or different non-ferromagnetic metals. Among them, the "first", "second", "third", and similar terms can be replaced with each other. The terms "including" or "containing" and similar terms used in the present application mean that the elements before this word cover the elements listed after this word, and do not exclude the possibility of also covering other elements. In the present application, the arrows shown in the figures for each step are only examples of the execution order and do not limit. The technical solutions of the present application are not limited to the execution order described in the embodiments. Each step in the execution order can be executed together, can be decomposed, and can be reordered as long as it does not affect the logical relationship of the execution content.

[0017] All terms used in this application (including technical or scientific terms) have the same meaning as understood by those of ordinary skill in the art to which this application pertains, unless otherwise specifically defined. It should also be understood that terms defined in general dictionaries should be interpreted as having meanings consistent with their meanings in the context of the relevant art, and should not be interpreted in an idealized or overly formal sense, unless specifically defined as such here. Technologies and devices known to those of ordinary skill in the relevant field may not be discussed in detail, but where appropriate, such technologies and devices should be regarded as part of the specification.

[0018] An embodiment of this application provides an fnirs system with a detachable harness and applicable to the MRI imaging scenario, as Figure 1 shown. The fnirs system includes a headcap 101, an SD probe group 102 disposed on the headcap 101, and a host 103. In the SD probe group 102, the S probe (emitting probe) is used to transmit near-infrared light to the subject. The near-infrared light has a certain penetrability and can penetrate tissues such as the scalp and skull and enter the cerebral cortex to a certain depth. When the near-infrared light irradiates the brain tissue, it will interact with substances such as hemoglobin in the tissue, and its reflected light carries information such as the oxygenation state of the brain tissue. The D probe (receiving probe) is used to receive the near-infrared light from the subject. By analyzing the changes in characteristics such as the intensity and wavelength of the optical signal received by the D probe, the blood oxygen changes in the cerebral cortex under different physiological or cognitive states can be indirectly obtained, thereby reflecting the functional activity state of the brain. Combining the two modalities of MRI and fnirs can simultaneously obtain the structural and functional information of the brain, clarify the anatomical structure details of the brain, and understand its functional activity state, which helps to more comprehensively and accurately evaluate brain function.

[0019] Among them, neither the headcap 101 nor the SD probe group 102 contains ferromagnetic materials, so that they can be placed inside the scanning hole of the MRI imaging system. In scenarios such as using MRI equipment, ferromagnetic materials will be attracted or interfered by the magnetic field, which may cause the headcap 101 and the SD probe group 102 to move or deform, affecting the accuracy and stability of the detection, and even possibly causing damage to the equipment or the human body. Therefore, neither the headcap 101 nor the SD probe group 102 contains ferromagnetic materials, which is beneficial to ensuring normal operation in a magnetic field environment and being free from the adverse effects of the magnetic field.

[0020] In this embodiment, a first optical fiber bundle is connected to the corresponding D probe on the headcap 101 worn by the subject, and the corresponding S probe can adopt different designs. For example, the S probe is connected to a second optical fiber bundle or a second electric wire.

[0021] Combined with Figure 2As shown, the host 103 is encapsulated in a shielding housing 104 and placed within a predetermined space range around the isocenter inside the scanning hole of the MRI imaging system. The shielding housing 104 is made of a first non-ferromagnetic metal to protect the electronic components and circuits inside the host 103 from electromagnetic interference, and at the same time prevent the electromagnetic signals generated by the host 103 itself from leaking out and interfering with the MRI device.

[0022] Metals such as aluminum, copper, gold, and silver are all non-ferromagnetic metals. In a preferred embodiment, the first non-ferromagnetic metal is aluminum. Aluminum is inexpensive, has a small density, and is light in weight, making it convenient for installation and movement. Making the shielding housing 104 of aluminum can effectively shield the strong magnetic field generated by the MRI imaging system and the electromagnetic waves in the surrounding environment.

[0023] Among them, the host 103 is encapsulated in the shielding housing 104 and placed within a predetermined space range around the isocenter inside the scanning hole of the MRI imaging system.

[0024] Specifically, during the process of MRI image acquisition, the gradient magnetic field plays a key role in spatial positioning. By applying gradient magnetic fields in three directions (usually the x-direction (transverse), y-direction (height direction), and z-direction (longitudinal)), the signal characteristics at different positions in space are made different. For example Figure 4 , the intensity of the gradient magnetic field changes with the radial distance from the isocenter (the distance from the isocenter in the x-y cross-section). The intensity of the gradient magnetic field is the smallest at the isocenter, and the farther away from the isocenter, the more obvious the change in the gradient magnetic field. The rate of change of the magnetic field intensity is the largest at the edge of the gradient coil.

[0025] In this way, by placing the host 103 as centered as possible inside the scanning hole, the magnetic field change at the position where the host 103 is located is smoother, and the induced electromagnetic force and eddy currents are smaller. Thus, the influence of the electromagnetic force on the host 103 can be reduced, avoiding displacement or damage of the components of the host 103 due to force, and at the same time reducing the heat generated by the eddy currents and the interference with the MRI magnetic field, which is beneficial to ensuring the normal operation of the fnirs device and the quality of the MRI image.

[0026] In some embodiments, the shielding housing 104 has a first dimension with a first size, a second dimension with a second size, and a third dimension with a third size, where the first size is less than the second size, and the second size is less than the third size.

[0027] Specifically, the first dimension is along the y-axis direction, the second dimension is along the x-axis direction, and the third dimension is along the z-axis direction. By setting the first dimension to be smaller than the second dimension, the cross-section of the shielding housing 104 in the x-y plane is a flat shape, which is convenient for stacking with other associated devices such as an electroencephalogram amplifier. When the main unit 103 is stacked with other devices, it should be kept not to deviate from the isocenter in the radial direction. Further, by setting the second dimension to be smaller than the third dimension, the largest third dimension of the shielding housing 104 is along the z-axis direction (return to see Figure 4 ), and the rate of change of the gradient magnetic field is relatively low over a sufficient length in the z-axis direction. In this way, a position with a relatively low rate of change of the gradient magnetic field can be found along the z-axis direction to place the shielding housing 104.

[0028] In some embodiments, the first dimension of the shielding housing 104 in the first dimension is less than 20 cm, or less than 18 cm, or less than 17 cm, or less than 16 cm, or less than 15 cm. In this way, it is beneficial for stacking with devices such as an electroencephalogram amplifier without being too close to the scanning hole wall in the radial direction, thereby reducing the influence of electromagnetic force, rate of change of magnetic field, etc. on the detection result.

[0029] In some embodiments, a support platform may also be provided within a predetermined peripheral space range of the isocenter in the scanning hole to place related devices such as an electroencephalogram amplifier associated with the MRI system, such as Figure 5 shown, the support platform is raised from the bottom of the scanning hole, so that the electroencephalogram amplifier and the main unit 103 stacked on the support platform are closer to the center of the scanning hole.

[0030] The overall layout of the MRI imaging system site mainly includes a control room where MRI professionals operate the MRI equipment (also known as the operating room), a scanning room directly opposite and connected to the control room (where the patient undergoes scanning, also known as the scanning chamber), and a machine room next to the scanning room (storing various cabinets related to MRI, including the radiofrequency transmission system, gradient transmission system, radiofrequency reception and reconstruction system, as well as the magnet refrigeration system and power supply, etc., also known as the equipment room). This site layout may also include a workstation (where doctors view and analyze MRI images) and a treatment room. Among them, in some cases, the workstation and the control room may also be integrated. When using modalities such as EEG and PET in combination with MRI, conductive gel or contrast agent is usually applied to the subject in the treatment room.

[0031] Returning to the embodiments of the present application, in combination with Figure 2, the host 103 includes a set of APD devices 105, a main processor 110, and a processing circuit 109. Among them, each APD device is configured to be connected to a corresponding D-probe on the headgear 101 via a first fiber optic bundle to receive near-infrared light emitted from the subject's head and convert it into an electrical signal. Among them, the package of each APD device is made of a non-ferromagnetic material, and the metal used for the pins or plating of each APD device is a second non-ferromagnetic metal.

[0032] The APD device, namely the avalanche photodiode, is arranged in the host 103. The APD device is connected to the corresponding D-probe on the headgear 101 through a first fiber optic bundle. The first fiber optic bundle has good light transmission characteristics and can efficiently transmit the near-infrared light emitted from the corresponding D-probe of the subject's headgear 101 to the APD device. This connection method can ensure that the near-infrared light signal collected by the D-probe is accurately transmitted to the APD device, reduce the loss and scattering of near-infrared light during the transmission process, and can accurately guide the near-infrared light to the corresponding APD device for detection, reducing the mutual interference between the wires (because it is a fiber optic bundle) exposed in the scanning hole and the magnetic field.

[0033] When the near-infrared light irradiates the APD device, the internal photoelectric effect will convert photons into electrons, thus generating an electrical signal. This process of converting the optical signal into an electrical signal is a key step in signal processing in the fnirs system. Subsequently, the host 103 can amplify, analyze, and process these electrical signals to obtain information about the functional state of the subject's brain, which is not limited here.

[0034] Among them, the package of each APD device is made of a non-ferromagnetic material to avoid interfering with the magnetic field intensity of the MRI imaging system, affecting the imaging quality, and avoiding damaging the equipment or causing harm to the subject.

[0035] The metal used for the pins or plating of each APD device is a second non-ferromagnetic metal. The pins are the key part for connecting the APD device to the external circuit and are used to transmit electrical signals. Using a non-ferromagnetic metal as the pin or plating material is also to prevent magnetic field interference in a magnetic field environment. The non-ferromagnetic metal can ensure that the pins will not be magnetized in the magnetic field, ensuring that the transmission of electrical signals is not affected by the magnetic field, so as to ensure that the APD device can stably and accurately convert the optical signal into an electrical signal and transmit the electrical signal to the subsequent circuit for processing.

[0036] In this embodiment, the main processor 110 and the processing circuit 109 are configured to be electrically connected to the set of APD devices 105, so as to obtain the electrical signals converted by the APD devices, and process the electrical signals to obtain fnirs detection data, wherein the metal used for the electrical devices and electrical connection lines is the third non-ferromagnetic metal.

[0037] In some embodiments, the second non-ferromagnetic metal and the third non-ferromagnetic metal are copper. Copper has a higher electrical conductivity, generates less eddy current and less heat under a changing magnetic field, and has a smaller magnetic permeability difference from air, which can reduce magnetic field interference, eddy current effect, heat generation and signal artifacts.

[0038] Specifically, for example, the processing circuit 109 may be responsible for the preliminary processing of the electrical signals. Since the electrical signals converted by the APD devices may be relatively weak and may contain some noise, operations such as amplification and filtering can be performed on the electrical signals to enhance the intensity of the electrical signals so that they reach a level that can be further processed by the main processor 110, and filtering can remove high-frequency noise or other interfering components in the electrical signals to improve the quality of the electrical signals.

[0039] Based on the preliminary processing of the electrical signals by the processing circuit 109, the main processor 110 can further analyze and process the electrical signals. The main processor 110 may use specific algorithms and models to perform operations such as feature extraction and data conversion on the electrical signals, and convert them into fnirs detection data that can reflect the brain function state of the subject. For example, by analyzing the changes in the electrical signals, the changes in blood oxygen concentration and hemodynamic parameters in different regions of the brain can be calculated, and the fnirs detection data can provide information about the brain function state of the subject for doctors or researchers.

[0040] In some embodiments, the processing circuit 109 further includes an electrostatic discharge protection unit, which is configured to prevent electrostatic hazards caused by, for example, the insertion and removal of the second wire bundle (it may also be the insertion and removal or movement of other optoelectronic devices such as the second optical fiber bundle). The electrostatic discharge protection unit can limit the voltage and current during electrostatic discharge by adopting a series of electrostatic protection measures, such as installing electrostatic discharge resistors, transient voltage suppression diodes (TVS) and other components. When static electricity is generated and accumulates to a certain extent, the electrostatic discharge protection unit can quickly guide the static electricity to the ground, or limit the transient high voltage generated by the electrostatic discharge within a safe range, thereby protecting electronic components from electrostatic hazards and ensuring the normal operation of the system and the stability of signal transmission.

[0041] The processing circuit 109 further includes an anti-aliasing filter configured to perform a low-pass operation with a cut-off frequency lower than the lower limit of the RF signal frequency emitted during the operation of the MRI imaging system and higher than twice the upper limit of the near-infrared brain functional imaging detection signal frequency, and the stopband attenuation is greater than a predetermined number of dB.

[0042] When the MRI imaging system operates, it emits radio frequency (RF) signals with a wide frequency range. The anti-aliasing filter is set with a cut-off frequency lower than the lower limit of the RF signal frequency emitted during the operation of the MRI imaging system to effectively prevent the RF signals of the MRI from entering the processing circuit 109 of the host 103 and avoid interfering with the near-infrared brain functional imaging detection signal.

[0043] The cut-off frequency of the anti-aliasing filter is set higher than twice the upper limit of the near-infrared brain functional imaging detection signal frequency. In this way, when sampling and processing the detection signal, it can ensure the integrity and accuracy of the signal, prevent high-frequency noise and other interference signals from passing through the filter, thereby improving the signal-to-noise ratio and resolution of the system and ensuring the quality of the near-infrared brain functional imaging detection signal. For example, the cut-off frequency of the anti-aliasing filter can be set between 100 Hz and 10 kHz, which can well filter out the RF signals of the MRI and well retain the near-infrared brain functional imaging detection signal.

[0044] The processing circuit 109 further includes an amplifier and an analog-to-digital converter. The amplifier is used to receive a differential input signal to suppress the common-mode interference brought by the MRI magnetic field. When the amplifier receives the differential input signal, it will perform a subtraction operation on the two input signals. Since the common-mode interference is basically the same in magnitude and phase on the two lines, during the subtraction process, the common-mode interference signal will be greatly weakened or even completely canceled. And the useful differential signal will be amplified normally. In this way, the amplifier effectively suppresses the common-mode interference brought by the MRI magnetic field through the processing of the differential input signal, improving the quality and stability of the signal. In this embodiment, the host 103 further includes a first fiber bundle interface 106, a second fiber bundle interface 107 or a second wire interface, and a communication interface 108. Among them, Figure 2 Only the second fiber bundle interface 107 is shown, and the second wire interface is not shown.

[0045] Among them, the first fiber bundle interface 106 is configured to detachably plug in the first fiber bundle group joint formed by the first fiber bundles, the second fiber bundle interface 107 or the second wire interface is configured to detachably plug in the second fiber bundle group joint formed by the second fiber bundles or the second wire bundle group joint formed by the second wires, and the communication interface 108 is configured to be connected to the upper computer via a communication path to transmit fnirs detection data thereto without introducing ferromagnetic materials.

[0046] Specifically, as Figure 3 shown, the fiber optic bundle interface 301 and the second wire interface 302 can be set on the host 103 simultaneously. Among them, the fiber optic bundle interface 301 includes a first fiber optic bundle interface and a second fiber optic bundle interface. Exemplarily, the distal ends of the first fiber optic bundle converge to form a first fiber optic bundle group joint 303, or the distal ends of the second wire bundle converge to form a second wire bundle group joint 304. Among them, each joint in the fiber optic bundle interface 301 corresponds one-to-one with each joint in the first fiber optic bundle group joint 303, and each joint in the second wire interface 302 corresponds one-to-one with each joint in the second wire bundle group joint 304.

[0047] In this way, the optical fiber and the second wire can be conveniently and accurately plugged into the host 103. Among them, the "distal end" is only used to represent the direction relative to the probe position. For example, the direction close to the probe position is the proximal end, and the direction far from the probe position is the distal end. "Proximal" and "distal" can vary according to different reference positions. The first fiber optic bundle group joint 303 and the second wire bundle group joint 304 can be split or integrated into one body, and the embodiments of the present application do not make specific limitations on this.

[0048] It should be noted that Figure 3 only one implementation manner is shown. The setting manner of the second fiber optic bundle group joint can be the same as the setting manner of the first fiber optic bundle group joint 303, or the first fiber optic bundle group joint 303 and the second fiber optic bundle group joint can be integrated into the same bundled joint component.

[0049] In addition, in the case of setting multiple first fiber optic bundle group joints 303 and multiple second wire bundle group joints 304, the fiber optic bundle interface 301 on the host 103 can be correspondingly configured according to the positions and quantities of the set first fiber optic bundle group joints 303 and the multiple second wire bundle group joints 304. That is to say, the respective interfaces on the host 103 can be configured according to the connection conditions of the optical fiber or the second wire connected to the probe, and no limitations are made on this.

[0050] In some embodiments, the fiber optic bundle group joint is formed with separate branches, each branch is set corresponding to each preset brain region, and each branch has different appearance attributes to identify the corresponding preset brain region. The first fiber optic bundle interface 106 or the second fiber optic bundle interface 107 has an identifier associated with the preset brain region.

[0051] Among them, the preset brain region can be one or more of the motor area, Broca's area, Wernicke's area, parietal association area, prefrontal cortex. Only by way of example, it does not constitute a specific limitation on the preset brain region, and the preset brain region can be set according to the detection requirements.

[0052] Specifically, the fiber optic bundle group connectors (including the first fiber optic bundle group connector and the second fiber optic bundle group connector) are set as separate parts, and each part is set corresponding to each preset brain region. The preset brain region corresponding to each part can be identified through the appearance attributes of each part, so that it is convenient to flexibly select the parts according to the preset brain regions of different subjects.

[0053] The appearance attributes of the parts can be the names, colors or numbers corresponding to the preset brain regions, and there is no limitation on this.

[0054] Exemplarily, assuming that the preset brain regions are the parietal lobe, the occipital lobe and the temporal lobe, the first fiber optic bundle group connectors corresponding to the parietal lobe can be assembled into one part, the first fiber optic bundle group connectors corresponding to the occipital lobe can be assembled into one part, and the first fiber optic bundle group connectors corresponding to the left and right temporal lobes can be respectively assembled into one part. In this way, the arrangement of the first fiber optic bundle group connectors can conform to each preset brain region of the subject's head, making the arrangement more orderly and less likely to be bent when the fiber optic bundles are connected.

[0055] Moreover, the first fiber optic bundle interface 106 and the second fiber optic bundle interface 107 have identifiers associated with the preset brain regions, so as to facilitate quickly identifying the interfaces corresponding to the preset brain regions, and thus it is convenient to quickly plug and unplug the parts on the first fiber optic bundle interface 106 or the second fiber optic bundle interface 107 on the host 103.

[0056] In some embodiments, the fiber optic bundle group connectors are formed with separate parts, and the fiber optic bundle interfaces are formed with separate notch arrays. Each part and its corresponding notch array have corresponding appearance attributes, so that the notches corresponding to each part can be conveniently identified based on the appearance attributes.

[0057] Specifically, taking the appearance attribute as color as an example, it can be set that the parts and notches with the same color have a corresponding relationship. In this way, it is convenient and accurate to realize the plugging and unplugging of each part on the corresponding notch array.

[0058] In some embodiments, the first fiber optic bundle interface 106, and the second fiber optic bundle interface 107 or the second wire interface are respectively arranged on at least two surfaces of the shielding housing 104, which can not only realize the reasonable distribution of the bundle group connectors on multiple surfaces of the shielding housing 104, but also facilitate the portable plugging when there are many bundle group connectors. For example, for a headcap with at least 100 channels, there are many bundle group connectors. By arranging each interface on at least two surfaces of the shielding housing 104, each bundle group connector can be evenly plugged on at least two surfaces of the shielding housing 104.

[0059] In some embodiments, when a second wire is connected to the S probe, the second wire harness group joint formed by the convergence of the second wires is single and is connected to the second wire interface. The single second wire harness group joint includes a pin header and a screw, and the second wire interface includes a female header and a threaded hole. The pin header is inserted into the female header, and the screw is screwed into the threaded hole.

[0060] Among them, the pin header - female header can be made of non - ferromagnetic metal, and the screw can be made of high - molecular materials such as carbon fiber, PVC or nylon.

[0061] Specifically, during use, the pin header in the single second wire harness group joint can be inserted into the female header in the second wire interface, and then the screw in the single second wire harness group joint can be screwed into the threaded hole in the second wire interface, thus conveniently realizing the insertion of the second wire harness group joint on the second wire interface of the host 103.

[0062] In some embodiments, the optical fiber bundle group joint includes a second mounting bracket and a group of optical fiber structure heads integrally formed therewith; or, the optical fiber bundle group joint includes a second mounting bracket and a group of optical fiber structure heads detachably screwed to the second mounting bracket.

[0063] Specifically, as Figure 3 , taking the first optical fiber bundle group joint 303 as an example for illustration.

[0064] Among them, the second mounting bracket 306 and a group of optical fiber structure heads 305 of the first optical fiber bundle group joint 303 can be an integrally formed structure. During the processing, processing the integrally formed structure is more conducive to improving the processing accuracy. And this integrally formed structure is also conducive to reducing the optical fiber coupling difference.

[0065] Or, the second mounting bracket 306 and a group of optical fiber structure heads 305 of the first optical fiber bundle group joint 303 can be a detachable connection method. For example, each optical fiber structure head 305 can be screwed onto the second mounting bracket 306 in a spiral connection manner to facilitate the replacement of each optical fiber structure head 305. For example, during the detection process, a single damaged optical fiber or optical fiber structure head 305 can be conveniently disassembled and a new optical fiber or optical fiber structure head 305 can be replaced.

[0066] In some embodiments, an optical fiber is fixed in each optical fiber structure head, and the second mounting bracket is further provided with at least two screws. The optical fiber bundle interface is provided with a group of notch openings corresponding one - to - one to the optical fiber structure heads and at least two threaded holes. When the optical fiber structure heads are all inserted into the corresponding notch openings, the screws are screwed into the corresponding threaded holes to complete the firm insertion of the optical fiber bundle group joint and the optical fiber bundle interface.

[0067] As Figure 3, Two screws 307 are provided on the second mounting bracket 306. Correspondingly, two threaded holes 308 are provided at the positions corresponding to the screws 307 on the optical fiber bundle interface 301, and the screws 307 are adapted to the threaded holes 308. Among them, the optical fiber structure heads 305 correspond one by one to the notches on the optical fiber bundle interface 301. By inserting the optical fiber structure heads 305 into the corresponding notches, optical signals are transmitted to the APD in the host 103.

[0068] When plugging the first optical fiber bundle group connector 303 into the host 103, insert each optical fiber structure head 305 into the corresponding notch on the optical fiber bundle interface 301, and screw the screws 307 into the corresponding threaded holes 308, thereby realizing the firm plugging of the first optical fiber bundle group connector 303 and the optical fiber bundle interface 301.

[0069] In some embodiments, the host further includes a first mounting bracket disposed in the shielding housing. The first mounting bracket is provided with a slot. The APD is embedded at one end of the slot, and a limiting thread is provided on the inner wall of the slot. The notches on the optical fiber bundle interface are provided corresponding to the APD one by one.

[0070] Exemplarily, as Figure 3 and Figure 6 , the light receiving end of the optical fiber structure head 305 can be connected to a D probe. The light emitting end of the optical fiber structure head 305 can be inserted into the slot in the first mounting bracket 601 through the notch on the optical fiber bundle interface 301 and directly connected to the APD 602. Specifically, there can be a gap between the light emitting end of the optical fiber structure head 305 and the APD 602, and a filter can be provided in the gap between the two to filter out interfering light other than near-infrared light.

[0071] The APD 602 can be stably installed through the first mounting bracket 601, so that the APD 602 and the optical fiber structure head 305 can maintain a relatively stable positional relationship.

[0072] The above-mentioned first mounting bracket 601 can be constructed in a plate shape, and the slots opened thereon can be provided corresponding to the APD 602 one by one.

[0073] Since the APD 602 generates heat during operation, and the magnetic field change in the scanning room can also cause the metal to heat up, temperature and heat itself will affect the working condition of the APD 602. The temperature sensor 603 can be used to monitor the heat generation situation of the APD 602 in real time. In some embodiments, the first mounting bracket 601 is made of a ceramic matrix composite material, polyimide or carbon fiber. These materials will not interfere with the magnetic field and will not generate artifacts during the MRI scanning process, and all have good thermal conductivity and hardness, and are suitable for use in the MRI scanning room.

[0074] In some embodiments, multiple temperature sensors 603 are embedded in the first mounting bracket 601, and each APD 602 surrounds and is adjacent to the corresponding temperature sensor 603. In this way, by using the temperature sensor 603 to monitor the temperature of the heat conductor, which is the first mounting bracket 601, that undergoes sufficient heat exchange with the APD 602, the temperature of the APD 602 can be indirectly monitored.

[0075] In some embodiments, the plate surface of the first mounting bracket 601 can be perpendicular to the axial direction of the fiber optic structure head 305.

[0076] Exemplarily, a threaded member can be sleeved on the light-emitting end of the fiber optic structure head 305, and the threaded member can be threadedly connected to the first mounting bracket 601, so that the fiber optic structure head 305 can be mounted on the first mounting bracket 601 through the threaded member.

[0077] In some embodiments, limiting threads are provided on the inner wall of the slot hole of the first mounting bracket 601. That is, after the threaded member of the fiber optic structure head 305 enters the position of the limiting threads, it cannot continue to enter inward. There is a certain gap, such as 1 mm, between the APD 602 embedded at one end of the slot hole and the limiting threads. In this way, through the positioning of the limiting threads, when the fiber optic structure head 305 is mounted on the first mounting bracket 601, the problem of crushing the APD 602 and causing it to break can be avoided, and the distance between the APD 602 and the fiber optic structure head 305 can also be limited, avoiding the influence on the optical coupling efficiency due to too far a distance.

[0078] In some embodiments, when the subject needs to cooperate with the EEG and PET modalities, the mainframe 103 can be fixedly placed in the scanning hole. Only the first fiber optic bundle group connector connected to the first fiber optic bundle interface 106 of the mainframe 103 and the second fiber optic bundle group connector connected to the second fiber optic bundle interface 107 of the mainframe 103 need to be unplugged to separate the fiber optic bundle group connectors from the mainframe 103. At this time, the subject can simply carry the first fiber optic bundle and the second fiber optic bundle to the treatment room for injection, and finally, after returning to the scanning room, the fiber optic bundle group connectors can be plugged into the mainframe 103. In this way, the operation time can be effectively reduced and the operation efficiency can be improved. At the same time, the convenience of the subject carrying the fiber optic and / or the second wire in and out of the scanning room is also improved.

[0079] In this embodiment, the communication interface 108 and the communication path can be communicatively connected to the upper computer in the control room (also called the operation room) in a wired manner without introducing ferromagnetic materials to transmit the fnirs detection data to it. For example, a communication cable can be passed through an opening (such as a reserved waveguide hole) in the wall of the scanning room.

[0080] Among them, the wired method can be an electric wire or an optical fiber. After the host 103 is placed in the scanning hole, the electric wire or optical fiber connected to the communication interface 108 passes through the hole in the wall and is connected to the upper computer in the control room. The electric wire or optical fiber for communication can be basically fixed. Once the host 103 needs to be moved, the electric wire or optical fiber for communication can be unplugged from the communication interface 108, and then inserted into the communication interface 108 again after the host 103 returns to the scanning hole and is in place. In this way, the electric wire or optical fiber for communication will not be dragged or moved, so even if it is relatively long, it will not affect the convenience of the subject's activities, nor will it affect the signal accuracy.

[0081] In addition, communication between the host 103 and the upper computer can also be carried out through a wireless transmission method. The wireless transmission method includes point-to-point communication in the 5G communication mode, Wifi direct (without a router) communication mode, etc., and there is no limitation on the wireless transmission method.

[0082] In some embodiments, the host 103 further includes a light source unit 111 that transmits near-infrared light to the corresponding S probe of the headcap 101 via a second optical fiber bundle, or a driving unit 112 that is connected to the corresponding S probe of the headcap 101 via a second electric wire to make a near-infrared LED emit near-infrared light.

[0083] Among them, the light source unit 111 can adopt a group of near-infrared LED devices. A light source driving circuit can also be accommodated in the shielding housing 104, and the light source driving circuit can drive the near-infrared LEDs to emit near-infrared light. There are no electronic devices provided in the corresponding S probe on the headcap 101 worn by the subject. In this case, the light source unit 111 emits near-infrared light, and transmits the near-infrared light to the corresponding S probe on the headcap 101 via the second optical fiber bundle.

[0084] Alternatively, near-infrared LEDs are installed in the corresponding S probe on the headcap 101 worn by the subject, and the host 103 is connected to each near-infrared LED at the corresponding S probe of the headcap 101 via a second electric wire. In this case, the driving unit 112 can transmit driving signals to each near-infrared LED at the corresponding S probe of the headcap 101 via the second electric wire, and each near-infrared LED generates near-infrared light based on the driving signals. The second electric wire can be made of copper. Copper has a higher electrical conductivity, generates less eddy current and less heat under a changing magnetic field, and has a smaller magnetic permeability difference from air, which can reduce magnetic field interference, eddy current effects, heat generation, and signal artifacts.

[0085] In some embodiments, the near-infrared LEDs are preferably made of materials that do not contain ferromagnetic materials, such as but not limited to lead-free perovskite near-infrared LEDs, organic semiconductors, and quantum dot (such as PbS quantum dots, Ag2S quantum dots) near-infrared LEDs, etc., which will not be elaborated here.

[0086] The light source unit 111 or the driving unit 112 operates under the control of the main processor 110 and the processing circuit 109, and the light source unit 111 or the driving unit 112 does not contain ferromagnetic materials.

[0087] The main processor 110 and the processing circuit 109 can generate corresponding control logics and instructions according to preset programs and algorithms, and these instructions will be transmitted to the light source unit 111 or the driving unit 112. For example, the main processor 110 and the processing circuit 109 will send instructions to the driving unit 112 according to the requirements of near-infrared detection, so that it drives the near-infrared LED to emit light at a specific frequency and intensity. Under the control of the main processor 110 and the processing circuit 109, the light source unit 111 can emit near-infrared light according to specific parameters and time sequences, such as controlling the intensity, wavelength, pulse frequency, etc. of the light, to meet the needs of the fnirs system for detecting the head of the subject. If the driving unit 112 is a component for driving the light source unit 111, it will accurately adjust parameters such as the driving current or voltage of the light source unit 111 according to the received instructions to ensure the stable and accurate operation of the light source unit 111.

[0088] The host 103 provided by the embodiment of the present application does not contain ferromagnetic materials, and has a small volume, and the size is suitable for being placed in the scanning hole of the MRI imaging system. The light source unit 111 or the driving unit 112 does not contain ferromagnetic materials, which can ensure stable and accurate operation in a magnetic field environment.

[0089] In some embodiments, the host is built-in with a rechargeable battery, and the rechargeable battery can provide power support for the host without external power access to ensure the normal operation of the device. Among them, the rechargeable battery can be a lead-acid battery, or a customized MRI-compatible battery, such as a nickel-metal hydride battery, a sodium battery with a non-metallic shell, a lithium-ion battery with a non-metallic shell, a solid-state battery with a non-metallic shell, etc., which is not limited herein.

[0090] Among them, Figure 5 The shown rechargeable battery can be a secondary battery 113, which is raised from the bottom of the scanning hole by a support platform, and the electroencephalogram amplifier, the host 103 and the secondary battery 113 are stacked on the support platform to be close to the center of the scanning hole.

[0091] For example, the host 103 built-in with the secondary battery 113 can be charged outside the scanning room, and can be placed in the scanning hole for use after charging is completed.

[0092] In addition, an external dedicated power supply unit can be provided to supply power to the host 103. The dedicated power supply unit has the characteristics of MRI safety and can work safely and stably in the MRI scanning environment, without generating electromagnetic interference to the MRI device, nor being affected by the strong MRI magnetic field and experiencing performance degradation or safety problems.

[0093] In some embodiments, the second wire includes a shielding layer, which can reduce the influence of external electromagnetic interference on the signals transmitted within the second wire, and at the same time prevent the signals within the second wire from radiating outwards to interfere with other devices. Exemplarily, the shielding layer can be a mesh or foil structure made of a metallic material (such as copper, aluminum, etc.), wrapped outside the insulating layer of the second wire, which can confine the external electromagnetic waves outside the shielding layer, or confine the electromagnetic waves generated inside the second wire within the shielding layer, thereby ensuring the stability and accuracy of signal transmission.

[0094] Moreover, the shielding layer is driven by a voltage follower. A voltage follower is an amplifier with a special circuit structure, whose output voltage can follow the change of the input voltage in real time and precisely, and has the characteristics of high input impedance and low output impedance. By using a voltage follower to drive the shielding layer of the second wire, the potential fluctuation on the shielding layer can be effectively reduced, and the electromagnetic interference caused by potential changes can be decreased. At the same time, the high input impedance of the voltage follower can avoid generating a loading effect on the circuit connected thereto, ensuring the stability of the reference voltage source or related potential. Driving the shielding layer of the second wire through a voltage follower in the scanning room instead of directly grounding can more effectively suppress the common-mode interference signals brought by the strong magnetic field to the second wire, ensure the transmission quality of the electrical signals, and improve the reliability and accuracy of the detection system.

[0095] In some embodiments of the present application, the fnirs detection data is transmitted to the control room via an optical fiber cable. The fnirs detection data reflects physiological information such as the blood oxygen change in the subject's brain under specific stimuli or tasks, and is an important basis for subsequent analysis and research of brain functions. There is limited space structure in the host, and it is impossible to install more processors. Merely through the main processor 110 and the processing circuit 109 in the host 103, more comprehensive detection results cannot be obtained. Therefore, it is necessary to transmit the fnirs detection data to the control room for processing.

[0096] Specifically, the fnirs detection data is transmitted in the form of optical signals in the fiber optic cable, which can ensure the accuracy and integrity of the fnirs detection data during transmission, and can achieve long-distance transmission without significant degradation of the signal quality. The fnirs detection data is transmitted to the control room via the fiber optic cable, which can be free from the influence of electromagnetic interference and can remain stable, thus avoiding artifacts introduced by electromagnetic interference. At the same time, the fiber has a high fidelity for transmitting optical signals, can accurately transmit various characteristics of the data, and reduces the possibility of artifacts caused by signal attenuation or distortion. Moreover, the fiber optic cable is relatively hard and flexible, and is not likely to generate signal changes due to slight movement, which can reduce the generation of motion artifacts to a certain extent.

[0097] In some embodiments, the probe buckle for fixing each probe on the headgear includes a lower buckle and an upper buckle. The upper buckle is provided with an optical fiber outlet, and the upper buckle is rotatable relative to the lower buckle to adjust the rotation direction according to the direction of the optical fiber.

[0098] Specifically, the lower buckle can be fixed on the headgear, and the upper buckle can be rotationally adjusted. The upper buckle can be rotated according to the arrangement and direction of the optical fiber to make the connection between the probe and the optical fiber smoother and more reasonable, ensure that the optical fiber can be naturally and conveniently connected to the probe, reduce the bending, twisting or stretching of the optical fiber, thereby avoiding adverse effects on the transmission of optical signals, ensuring that the optical signals can be efficiently and stably transmitted between the optical fiber and the probe, and at the same time preventing the optical fiber from being damaged due to large-angle bending and extending the service life of the optical fiber.

[0099] In some embodiments, the optical fiber is sleeved with a bamboo joint protective sleeve. The bamboo joint protective sleeve can be prepared from a material with a certain degree of flexibility and rigidity, and has good wear resistance, which can protect the optical fiber for a long time in various complex use environments and extend the service life of the optical fiber. Specifically, the bamboo joint protective sleeve includes separated sleeve sections, and each sleeve section can be made of a light material with appropriate flexibility and rigidity. Through the locking of the structural heads at both ends of the optical fiber, each sleeve section can be sequentially sleeved on the optical fiber with a certain clearance reserved. In this way, during the use of the optical fiber, bending will be restricted by several adjacent sleeve sections, thus avoiding large-angle bending, and ensuring the normal operation of the fnirs system and detection stability.

[0100] In some embodiments, the SD probe group includes a high SD probe group and a low SD probe group. Among them, the use of the high SD probe group or the low SD probe group is determined based on the accommodation space of the radio frequency coil in the scanning room; the probes in the high SD probe group include probe adapters equipped with springs; the probes in the low SD probe group include light transmission members that can guide the near-infrared light emitted by an external light source to the head of the subject.

[0101] Specifically, the SD probe group on the headgear is replaceable. For each probe in the high SD probe group, the probe can be relatively easily assembled onto the headgear through a probe adapter equipped with a spring inside, and can fit well onto the head of the subject to be examined. Moreover, the height is relatively high and the occupied space is relatively large.

[0102] For each probe in the low SD probe group, a relatively flat structure is adopted. Inside the probe, there is an optical transmission component (such as an optical fiber) that can guide the near-infrared light emitted by an external light source to the head of the subject to be examined, and there are no metal components. In some embodiments, the height of each probe in the low SD probe group is 6 mm - 20 mm, which is relatively lower than the height of each probe in the high SD probe group, and the occupied space is relatively small.

[0103] Therefore, it is possible to decide whether to use the high SD probe group or the low SD probe group according to the accommodation space of the RF coil in the scanning room. The spatial size of the RF coil limits the size and structure of the probe, and different probe groups need to be matched to optimize the scanning effect.

[0104] Furthermore, the headgear is a first headgear configured with a high SD probe group or a second headgear configured with a low SD probe group, wherein the use of the first headgear or the second headgear is determined based on the accommodation space of the RF coil in the scanning room. That is to say, headgears configured with probes of different heights can be set respectively. For example, each probe on the first headgear is a high probe, and each probe on the second headgear is a low probe. When the connection methods of the high SD probe group and the low SD probe group to the headgear are different, this method can be adopted.

[0105] In the scanning room, the head of the subject to be examined is in the RF coil space, and the RF coil space is limited. If the RF coil space is relatively large, the subject can wear the first headgear, while in the case of a relatively small RF coil space, the subject can wear the second headgear. In this way, the headgear can be flexibly selected according to the size of the RF coil space.

[0106] It can be understood that the above SD probe group includes a high SD probe group and a low SD probe group, which can be realized only by replacing the probe group on the headgear, or by replacing the headgear. Here, there is no specific limitation on how to specifically use the high SD probe group and the low SD probe group.

[0107] In some embodiments, the high SD probe group is configured to be used in cooperation with EEG electrodes to achieve triple-modal detection of MRI, fnirs, and EEG.

[0108] Specifically, in the case where the subject needs to cooperate with the EEG (electroencephalogram) modality, in order to meet the requirements of EEG testing, the SD probe group on the headgear worn by the subject needs to be replaced with a high-SD probe group. The probes in the high-SD probe group include probe adapters equipped with springs, and the elasticity of the springs can buffer the contact pressure between each probe and the subject's head, ensuring that the probes closely fit the head surface, especially suitable for the case of an irregular head shape. During the scanning process, the springs can adapt to the slight movement of the head and maintain stable signal acquisition (such as the scenario of slight head shaking in functional magnetic resonance imaging fMRI).

[0109] Meanwhile, in order to achieve triple-modal detection of MRI, fnirs, and EEG, generally, electrode seats for EEG testing are configured on the headgear, and conductive paste needs to be applied to the subject's head. By replacing the SD probe group worn on the headgear with a high-SD probe group, the subject can not only meet the requirement of applying conductive paste but also make the probes closer to the scalp through the springs, thereby accurately collecting electroencephalogram signals. It can be understood that the use of the high-SD probe group for the SD probe group can be achieved by simply replacing the probe group on the headgear or by directly replacing the headgear. The specific replacement method is not limited here.

[0110] In some embodiments, the fnirs system includes at least a first set of headgear and an SD probe group configured on the first set of headgear, a second set of headgear, and an SD probe group configured on the second set of headgear. That is to say, at least two sets of headgear can be provided for the subject, and the models of these two sets of headgear can be exactly the same or different, which is not limited here.

[0111] The host includes a test host set in the scanning room and a debugging host set in the target area outside the scanning room. Among them, the models of the test host and the debugging host are exactly the same. The target area can be, for example, a control room, a treatment room outside the control room, etc., which is not limited here.

[0112] Among them, the first set of headgear and the SD probe group configured on the first set of headgear are configured to be plugged into the debugging host through a fiber optic bundle group connector or a second wire bundle group connector in the target area for preliminary debugging, and then pulled out by the debugging host after the preliminary debugging is completed; after entering the scanning room, it is plugged into the test host through the fiber optic bundle group connector or the second wire bundle group connector on the first set of headgear to finely adjust the fit between each probe on the first set of headgear and the scalp, and a complete detection is carried out after the fine adjustment is completed.

[0113] Specifically, when the target area is a control room, and the subjects include a first subject wearing a first headgear and a second subject wearing a second headgear, in the control room, the second optical fiber bundle group connector or the second wire bundle group connector on the first headgear worn by the first subject is plugged into the debugging host in the control room. After the first optical fiber bundle group connector on the first headgear is plugged into the debugging host, fnirs detection is performed, and based on the fnirs detection results, the fitting degree of each probe on the first headgear to the scalp is preliminarily debugged.

[0114] After the preliminary debugging based on the first headgear and the SD probe group configured on the headgear is completed, the optical fiber bundle group connector or the second wire connector is unplugged from the debugging host. The first subject wears the first headgear and enters the scanning room. Then, the optical fiber bundle group connector or the second wire bundle group connector on the first headgear is plugged into the test host in the scanning room, fnirs detection is performed, and then according to the fnirs detection results, the fitting degree of each probe on the first headgear to the scalp is finely debugged. After the fine debugging is completed, a complete detection (including at least MRI scanning and fnirs detection) is performed.

[0115] Among them, after unplugging the optical fiber bundle group connector or the second wire bundle group connector on the first headgear worn by the first subject in the control room from the debugging host, the debugging host is released, so that the debugging host is in an idle state. At this time, it is allowed for the second subject to wear the second headgear to debug the SD probe group on the second headgear. The optical fiber bundle group connector or the second wire bundle group connector on the second headgear is plugged into the debugging host for fnirs detection to preliminarily debug the fitting degree of each probe on the second headgear to the scalp.

[0116] Exemplarily, during the process of the second subject performing preliminary debugging in the control room, the first subject can wear the first headgear and enter the scanning room. After finely adjusting the fitting degree of each probe on the first headgear to the scalp, a complete detection can be performed, greatly improving the debugging efficiency.

[0117] Moreover, after the first subject completes the entire detection in the scanning room, the second subject wears the second headgear and enters the scanning room, and plugs the optical fiber bundle group connector or the second wire bundle group connector on the second headgear into the test host, then the individual probes on the second headgear can be finely adjusted, and after the fine adjustment is completed, a complete detection can be performed.

[0118] In this way, the time when the subject waits in the control room for the previous subject to complete the entire detection can be fully utilized, greatly improving the debugging efficiency, thereby further shortening the detection time and increasing the utilization rate of the MRI system.

[0119] That is to say, the second headgear and the SD probe group configured on the second headgear are configured to: after the fiber optic cable group connector or the second wire harness group connector on the first headgear is pulled out by the debugging host, use the second headgear and the SD probe group configured on the second headgear, and insert them into the debugging host through the fiber optic cable group connector or the second wire harness group connector on the second headgear in the target area for preliminary debugging. After the preliminary debugging is completed, it is pulled out by the debugging host; and after the complete detection performed based on the first headgear and the SD probe group configured on the headgear is completed, enter the scanning room, and insert them into the test host through the fiber optic cable group connector or the second wire harness group connector for fine debugging. After the fine debugging is completed, a complete detection is carried out.

[0120] Throughout this entire process, the subject can carry the cable and move conveniently, and can easily plug the cable into the host or disassemble it from the host. Moreover, generally speaking, when there are a large number of subjects waiting for debugging, queuing is often required. Based on the fnirs system provided by the embodiments of the present application, the subject can be debugged during the waiting period of the previous person's detection, and only fine-tuning is required after entering the scanning room later, which greatly shortens the detection time, improves the utilization rate of the MRI system, and overall improves the debugging efficiency and debugging accuracy. The present application describes various operations or functions, which can be implemented as software code or instructions or be defined as software code or instructions. Such content can be source code that can be directly executed or differential code ("incremental" or "patch" code) ("object" or "executable" form). The software code or instructions can be stored in a computer-readable storage medium, and when executed, can cause a machine to execute the described functions or operations, and include any mechanism for storing information in a form accessible by a machine (e.g., a computing device, an electronic system, etc.), such as a recordable or non-recordable medium (e.g., read-only memory (ROM), random access memory (RAM), magnetic disk storage medium, optical storage medium, flash device, etc.).

[0121] In addition, although exemplary embodiments have been described herein, the scope includes any and all embodiments based on the present application having equivalent elements, modifications, omissions, combinations (e.g., solutions that cross various embodiments), adaptations, or changes. The elements in the claims will be broadly interpreted based on the language used in the claims and are not limited to the examples described in this specification or during the implementation of the present application, and the examples will be interpreted as non-exclusive. Therefore, this specification and the examples are intended to be considered only as examples, and the true scope and spirit are indicated by the following claims and the entire scope of their equivalents.

[0122] The foregoing description is intended to be illustrative and not restrictive. For example, the above examples (or one or more aspects thereof) may be used in combination with each other. For example, other embodiments may be used by those of ordinary skill in the art upon reading the above description. Additionally, in the above detailed description, various features may be grouped together to simplify the present application. This should not be construed as an intention that any non-claimed disclosed feature is necessary for any claim. On the contrary, the subject matter of the present application may be less than all the features of a particular disclosed embodiment. Thus, the claims are hereby incorporated into the detailed description by way of example or embodiment, where each claim stands on its own as a separate embodiment, and it is contemplated that these embodiments may be combined with each other in various combinations or permutations. The scope of the present application shall be determined with reference to the appended claims and the full scope of equivalents to which such claims are entitled.

[0123] The above embodiments are only exemplary embodiments of the present application and are not used to limit the present application. The protection scope of the present application is defined by the claims. Those skilled in the art can make various modifications or equivalent replacements within the essence and protection scope of the present application, and such modifications or equivalent replacements should also be regarded as falling within the protection scope of the present application.

Claims

1. A wire harness that is pluggable and can be used in an fnirs system for MRI imaging scenarios, where The fnirs system includes: A headcap and an SD probe group disposed on the headcap. The S probe is used to transmit near-infrared light to the subject, and the D probe is used to receive the near-infrared light from the subject. Neither the headcap nor the SD probe group contains ferromagnetic materials so that they can be placed inside the scanning hole of the MRI imaging system. The S probe is connected to a second fiber bundle or a second electric wire, and the D probe is connected to a first fiber bundle; and A mainframe, which is encapsulated in a shielding housing to be placed within a predetermined space range around the isocenter inside the scanning hole of the MRI imaging system. The shielding housing is made of a first non-ferromagnetic metal. The mainframe includes: A group of APD devices, each of which is respectively configured to be connected to a corresponding D probe on the headcap via the first fiber bundle to receive the near-infrared light emitted from the subject's head and convert it into an electrical signal; A main processor and a processing circuit, which are configured to be electrically connected to the group of APD devices to process the electrical signal to obtain fnirs detection data; A first fiber bundle interface, which is configured to detachably plug in a first fiber bundle group connector formed by the convergence of the first fiber bundles; A second fiber bundle interface or a second electric wire interface, which is configured to detachably plug in a second fiber bundle group connector formed by the convergence of the second fiber bundles or a second electric wire group connector formed by the convergence of the second electric wires; and A communication interface, which is configured to be connected to a host computer via a communication path to transmit fnirs detection data thereto without introducing ferromagnetic materials.

2. The fnirs system according to claim 1, wherein The fiber bundle group connector is formed with separated segments, each segment is set corresponding to each preset brain region, and each segment has different appearance attributes to identify the corresponding preset brain region. The first fiber bundle interface or the second fiber bundle interface has an identifier associated with the preset brain region.

3. The fnirs system according to claim 1, characterized in that, The fiber bundle group connector is formed with separated segments, and the fiber bundle interface is formed with a separated notch array. Each segment and its corresponding notch array have corresponding appearance attributes.

4. The fnirs system according to claim 1, characterized in that, The first fiber bundle interface, and the second fiber bundle interface or the second electric wire interface are respectively disposed on at least two surfaces of the shielding housing.

5. The fnirs system according to claim 1, characterized in that, When the S probe is connected to a second electric wire, the second electric wire group connector formed by the convergence of the second electric wires is single and is connected to the second electric wire interface. The single second electric wire group connector includes a pin header and a screw, and the second electric wire interface includes a female header and a threaded hole. The pin header is plugged into the female header, and the screw is screwed into the threaded hole.

6. The fnirs system according to claim 1, characterized in that, The mainframe further includes a first mounting bracket disposed inside the shielding housing. The first mounting bracket is provided with a slot hole. The APD is embedded at one end of the slot hole. The inner wall of the slot hole is provided with a limiting thread. A plurality of notches are formed on the fiber bundle interface, and each notch is set corresponding to each APD.

7. The fnirs system according to any one of claims 1-6, characterized in that, The fiber optic bundle group connector includes a second mounting bracket and a set of fiber optic structure heads integrally formed therewith. Optical fibers are fixed in each of the fiber optic structure heads. The second mounting bracket is further provided with at least two screws. The fiber optic bundle interface is provided with a set of notches corresponding to the fiber optic structure heads one by one and at least two threaded holes. When the fiber optic structure heads are all inserted into the corresponding notches, the screws are screwed into the corresponding threaded holes to complete the firm plugging of the fiber optic bundle group connector and the fiber optic bundle interface.

8. The fnirs system according to any one of claims 1-6, characterized in that, The fiber optic bundle group connector includes a second mounting bracket and a set of fiber optic structure heads detachably screwed onto the second mounting bracket. Optical fibers are fixed in each of the fiber optic structure heads. The second mounting bracket is further provided with at least two screws. The fiber optic bundle interface is provided with a set of notches corresponding to the fiber optic structure heads one by one and at least two threaded holes. When the fiber optic structure heads are all inserted into the corresponding notches, the screws are screwed into the corresponding threaded holes to complete the firm plugging of the fiber optic bundle group connector and the fiber optic bundle interface.

9. The fnirs system according to claim 6, wherein The first mounting bracket is made of ceramic matrix composite material, polyimide or carbon fiber. A plurality of temperature sensors are embedded in the first mounting bracket, and each APD surrounds and is adjacent to the corresponding temperature sensor.

10. The fnirs system according to any one of claims 1-6, characterized in that, The second wire includes a shielding layer, and the shielding layer is driven by a voltage follower.

11. The fnirs system according to any one of claims 1-6, characterized in that, The processing circuit further includes: An electrostatic discharge protection unit configured to prevent electrostatic hazards caused by the plugging and unplugging of the second wire bundle; An anti-aliasing filter configured to perform a low-pass operation with a cut-off frequency lower than the lower limit of the RF signal frequency emitted when the MRI imaging system operates and higher than twice the upper limit of the near-infrared brain function imaging detection signal frequency, and the stopband attenuation is greater than a predetermined dB number; An amplifier and an analog-to-digital converter, where the amplifier is used to receive a differential input signal to suppress the common-mode interference brought by the MRI magnetic field.

12. The fnirs system according to any one of claims 1-6, characterized in that, The probe fastener for fixing each probe on the headcap includes a lower fastener and an upper fastener. The upper fastener is provided with an optical fiber outlet, and the upper fastener is rotatable relative to the lower fastener to adjust the rotation direction according to the direction of the optical fiber.

13. The fnirs system according to any one of claims 1-6, characterized in that, The SD probe group includes a high SD probe group and a low SD probe group. Among them, the use of the high SD probe group or the low SD probe group is determined based on the accommodation space of the RF coil in the scanning room; The probes in the high SD probe group include probe adapters equipped with springs; The probes in the low SD probe group include light transmission members capable of guiding the near-infrared light emitted by an external light source to the head of the subject to be examined.

14. The fnirs system according to claim 13, wherein The high SD probe group is configured to be used in cooperation with EEG electrodes to achieve triple-modal detection of MRI, fnirs, and EEG.

15. The fnirs system according to claim 1, wherein The fnirs system includes at least a first headcap and an SD probe group configured on the first headcap, a second headcap and an SD probe group configured on the second headcap. The host includes a test host arranged in the scanning room and a debugging host arranged in the target area outside the scanning room; The first headgear and the SD probe group configured on the first headgear are configured to: perform preliminary debugging in the target area by plugging into the debugging host through the fiber optic bundle group connector or the second wire harness group connector, and be pulled out by the debugging host after the preliminary debugging is completed; after entering the scanning room, plug into the test host through the fiber optic bundle group connector or the second wire harness group connector on the first headgear to perform fine debugging on the fit of each probe on the first headgear to the scalp, and perform a complete detection after the fine debugging is completed; The second headgear and the SD probe group configured on the second headgear are configured to: after the fiber optic bundle group connector or the second wire harness group connector on the first headgear is pulled out by the debugging host, use the second headgear and the SD probe group configured on the second headgear to perform preliminary debugging in the target area by plugging into the debugging host through the fiber optic bundle group connector or the second wire harness group connector on the second headgear, and be pulled out by the debugging host after the preliminary debugging is completed; and after the complete detection performed based on the first headgear and the SD probe group configured on the first headgear is completed, enter the scanning room, plug into the test host through the fiber optic bundle group connector or the second wire harness group connector to perform fine debugging, and perform a complete detection after the fine debugging is completed.

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