Culture device for mouse tumor cells
By designing an automated access and correction mechanism, the problems of low placement efficiency and low survival rate of mouse tumor cell culture devices in the prior art are solved, and efficient and safe cell culture effects are achieved.
Patent Information
- Application Number
- CN202510266634.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-07
- Publication Date
- 2025-07-18
- Estimated Expiration
- 2045-03-07
AI Technical Summary
In the prior art, the mouse tumor cell culture device has low efficiency in placing and adjusting spacing on multiple culture dishes, resulting in a low cell survival rate, and the culture dish has been in the external environment for too long and affects the culture effect.
A mouse tumor cell culture device was designed, including an access mechanism, a calibration mechanism and a driving mechanism to automatically place and adjust the position of the Petri dish, ensure the constant spacing and sealing of the Petri dish, and reduce the contact time of the external environment.
It improves the efficiency of the placement of the Petri dish in the device, enhances the air circulation and temperature uniformity, improves the survival rate of mouse tumor cells, and ensures the safety and sealing of the Petri dish removal process.
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Figure CN120330048A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of cell culture, and particularly relates to a culture device for mouse tumor cells. Background Art
[0002] Cell culture refers to a method of simulating the in-vivo environment in vitro to enable cells to survive, grow, reproduce, and maintain their main structures and functions. Whether for the entire bioengineering technology or one of its sub-technologies, namely bio-cloning technology, cell culture is an essential process. Cell culture itself is large-scale cloning of cells. Culturing mouse tumor cells can provide important experimental models and tools for tumor research, helping to more deeply understand the biological characteristics, growth mechanisms, and metastasis pathways of tumors, and providing scientific bases and technical supports for the diagnosis, treatment, and prevention of tumors. During the process of culturing mouse tumor cells, a culture device is needed to provide suitable temperature and humidity for cell growth.
[0003] During the use of the existing culture devices, when it is necessary to culture multiple types of mouse tumor cells, it is required to first place the multiple types of mouse tumor cells in multiple culture dishes respectively, and then manually place the multiple culture dishes neatly in the culture device in sequence, and adjust the spacing between the multiple culture dishes to make the spacing between them constant. Manually placing the multiple culture dishes in the culture device and adjusting their spacing is inefficient, and it will cause the culture dishes to be in the external environment for a long time, resulting in a lower survival rate of the mouse tumor cells inside the culture dishes during subsequent culture processes, affecting the normal culture of mouse tumor cells. Summary of the Invention
[0004] The purpose of the present invention is to solve the deficiencies existing in the prior art, and to propose a culture device for mouse tumor cells.
[0005] To achieve the above purpose, the present invention adopts the following technical solutions: A culture device for mouse tumor cells, including a device body. A sealing door is installed on the front of the device body. A plurality of placement racks are installed inside the device body. Placement grooves for temporarily placing culture dishes are opened at the tops of the plurality of placement racks. A storage and retrieval mechanism for automatically retrieving and placing culture dishes is provided inside each of the plurality of placement racks. The storage and retrieval mechanism includes a plurality of placement plates installed inside the placement racks. Each of the plurality of placement plates is divided into a plurality of placement chambers by a plurality of partition plates provided inside. A calibration mechanism for calibrating the position of the culture dish is provided inside each of the plurality of placement chambers. Driving mechanisms for driving the calibration mechanism to work are provided on the upper and lower sides of the plurality of placement racks inside the device body.
[0006] Optionally, the access mechanism further includes two rectangular strip plates disposed above the plurality of placement plates. Two sets of first electric telescopic rods are installed inside each of the plurality of placement plates, and the telescopic ends of the two sets of first electric telescopic rods are respectively connected to the rectangular strip plates adjacent thereto.
[0007] Optionally, first sliding grooves are formed on the outer walls of the adjacent sides of the two rectangular strip plates. First sliding blocks are installed inside the two first sliding grooves. One ends of the two first sliding blocks adjacent to each other are connected by a second electric telescopic rod to a clamping plate for clamping and fixing the culture dish.
[0008] Optionally, circular grooves are formed on the inner bottom surfaces of the plurality of placement chambers, and circular blocks are placed inside the plurality of circular grooves.
[0009] Optionally, the calibration mechanism includes moving plates disposed on the four inner walls of the placement chamber. A plurality of second sliding grooves are formed on the inner bottom surface of the placement chamber, and second sliding blocks capable of moving back and forth in the second sliding grooves are installed at the bottoms of the four moving plates.
[0010] Optionally, a plurality of rectangular grooves are further formed on the inner bottom surface of the placement chamber. Rectangular blocks capable of sliding back and forth in the rectangular grooves are installed at the bottoms of the four moving plates, and springs are installed between the four rectangular blocks and one inner wall of the rectangular grooves.
[0011] Optionally, the bottom ends of the four rectangular blocks all pass through the rectangular grooves and are rotatably installed with connecting plates. A connecting sleeve is disposed directly below the placement chamber, and one ends of the plurality of connecting plates far from the rectangular blocks are all hinged to the outer wall of the connecting sleeve.
[0012] Optionally, the driving mechanism includes a plurality of third sliding grooves formed on the inner walls on both sides of the device body. Third sliding blocks are installed inside the plurality of third sliding grooves, and one ends of the plurality of third sliding blocks far from the third sliding grooves are commonly connected to a mounting plate.
[0013] Optionally, a plurality of through grooves are formed inside the mounting plate. A plurality of rotating blocks having the same number as the placement chambers are rotatably installed inside the plurality of through grooves. Third electric telescopic rods are installed at the tops of the plurality of rotating blocks, and the diameter of the third electric telescopic rods is smaller than the inner diameter of the connecting sleeve.
[0014] Optionally, rubber blocks are installed at the telescopic ends of the plurality of third electric telescopic rods, and two telescopic limiting rods are installed inside the telescopic ends of the plurality of third electric telescopic rods.
[0015] The beneficial effects of the present invention are: 1. In this invention, when multiple culture dishes need to be placed inside the device body for culturing, the access mechanism provided inside the device body can be used to place the multiple culture dishes in sequence. There is no need for manual repetition of placing and adjusting the spacing of the multiple culture dishes, which improves the efficiency of placing the multiple culture dishes inside the device body, reduces the time of the culture dishes in the external environment, and improves the survival rate of mouse tumor cell culture.
[0016] 2. In this invention, after the culture dish is placed inside the corresponding placement chamber, the calibration mechanism provided inside the placement chamber can control the constant spacing between the culture dish inside the placement chamber and the inner wall of the placement chamber, ensuring the air circulation and uniform temperature inside the device body where the culture dish is located, and facilitating the normal growth of tumor cells inside the culture dish.
[0017] 3. In this invention, and after the culture dish is placed inside the placement chamber, with the help of the calibration mechanism to correct its position, it is also convenient for the subsequent process of taking out the culture dish. During the process that the third electric telescopic rod moving upward drives the round block to move upward together, the culture dish is located at the center position on the top of the round block, making the upward movement of the culture dish relatively safe and stable, facilitating the subsequent quick and accurate clamping and fixing of the culture dish by the two clamping plates, and improving the safety during the process of taking out the culture dish.
[0018] 4. In this invention, after the multiple culture dishes are placed in sequence inside the multiple placement chambers, the multiple rotating blocks inside the mounting plate above the placement rack can be controlled to drive the multiple third electric telescopic rods to rotate downward to a vertical state, and then control the mounting plate and the third electric telescopic rods in a vertical state below it to move downward together. Control the telescopic ends of the multiple third electric telescopic rods to extend downward, drive the multiple rubber blocks to contact the lids on the tops of the culture dishes, and press the lids of the culture dishes with the downward - moving rubber blocks, ensuring that the multiple culture dishes are in a sealed state inside the placement chambers, and avoiding the situation that the sealing between the lid and the culture dish is not tight, resulting in a low survival rate of mouse tumor cells inside the culture dish. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] For the convenience of those skilled in the art to understand, the present invention will be further described below with reference to the drawings.
[0020] Figure 1 It is a schematic diagram of the overall structure of a culture device for mouse tumor cells proposed by the present invention; Figure 2 It is a schematic diagram of the internal structure of the device body in the present invention; Figure 3 It is a schematic diagram of the structure of the placement rack and the mounting plate in the present invention; Figure 4 It is a schematic diagram of the bottom structure of the placement rack in the present invention; Figure 5 The structural schematic diagram of the mounting plate in the present invention; Figure 6 The structural schematic diagram of the third electric telescopic rod in the present invention; Figure 7 The structural schematic diagram of the placing plate and the rectangular strip plate in the present invention; Figure 8 The structural schematic diagram of the separation of the rectangular strip plate and the placing plate in the present invention; Figure 9 The structural schematic diagram of the separation of multiple moving plates and the placing plate in the present invention; Figure 10 The structural schematic diagram of the calibration mechanism in the present invention.
[0021] In the figure: 1, device body; 2, sealing door; 3, placing rack; 4, mounting plate; 5, third chute; 6, third slider; 7, through groove; 8, third electric telescopic rod; 9, placing groove; 10, rectangular strip plate; 11, placing plate; 12, connecting sleeve; 13, rotating block; 14, telescopic limiting rod; 15, rubber block; 16, clamping plate; 17, round block; 18, moving plate; 19, first chute; 20, first electric telescopic rod; 21, first slider; 22, second electric telescopic rod; 23, partition board; 24, round groove; 25, rectangular groove; 26, second chute; 27, connecting plate; 28, spring; 29, second slider; 30, rectangular block. Detailed implementation manners
[0022] Next, the technical solutions of the present invention will be clearly and completely described in conjunction with the embodiments. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.
[0023] Refer to Figures 1 - 10 , a culture device for mouse tumor cells, comprising a device body 1, a sealing door 2 is installed on the front surface of the device body 1, a plurality of placing racks 3 are installed inside the device body 1, placing grooves 9 for temporarily placing culture dishes are opened at the tops of the plurality of placing racks 3, an access mechanism for automatically picking and placing the culture dishes is arranged inside the plurality of placing racks 3, the access mechanism includes a plurality of placing plates 11 installed inside the placing racks 3, the interiors of the plurality of placing plates 11 are separated into a plurality of placing chambers by a plurality of partition boards 23 arranged therein, a calibration mechanism for calibrating the position of the culture dish is arranged inside each of the plurality of placing chambers, and driving mechanisms for driving the calibration mechanism to work are arranged on the upper and lower sides of the plurality of placing racks 3 inside the device body 1.
[0024] As a technical optimization solution of the present invention, the access mechanism further includes two rectangular strip plates 10 disposed above a plurality of placement plates 11. Two sets of first electric telescopic rods 20 are installed inside each of the plurality of placement plates 11, and the telescopic ends of the two sets of first electric telescopic rods 20 are respectively connected to the rectangular strip plates 10 adjacent thereto. When the telescopic ends of the first electric telescopic rods 20 expand and contract, the rectangular strip plates 10 can be driven to move up and down on the tops of the placement plates 11, so that the height of the rectangular strip plates 10 can be adjusted.
[0025] As a technical optimization solution of the present invention, first chutes 19 are provided on the outer walls of the two rectangular strip plates 10 adjacent to each other. First sliders 21 are installed inside each of the two first chutes 19. The adjacent ends of the two first sliders 21 are both connected to clamping plates 16 for clamping and fixing culture dishes through second electric telescopic rods 22. First linear motors are pre-installed inside each of the two first chutes 19. The first linear motors can drive the first sliders 21 to move back and forth inside the first chutes 19, so as to be able to drive the second electric telescopic rods 22 and the clamping plates 16 to move accordingly.
[0026] As a technical optimization solution of the present invention, circular grooves 24 are provided on the inner bottom surfaces of a plurality of placement chambers, and circular blocks 17 are placed inside each of the plurality of circular grooves 24.
[0027] As a technical optimization solution of the present invention, the calibration mechanism includes moving plates 18 provided on the four inner walls of the placement chamber. A plurality of second chutes 26 are provided on the inner bottom surface of the placement chamber, and second sliders 29 capable of moving back and forth inside the second chutes 26 are installed at the bottoms of the four moving plates 18. The second sliders 29 provided at the bottoms of the moving plates 18 can define the moving trajectories of the moving plates 18, so that they move in a straight line state.
[0028] As a technical optimization solution of the present invention, a plurality of rectangular grooves 25 are further provided on the inner bottom surface of the placement chamber. Rectangular blocks 30 capable of sliding back and forth inside the rectangular grooves 25 are installed at the bottoms of the four moving plates 18, and springs 28 are installed between each of the four rectangular blocks 30 and one inner wall of the rectangular grooves 25.
[0029] As a technical optimization solution of the present invention, connecting plates 27 are rotatably installed at the bottom ends of the four rectangular blocks 30 through the rectangular slots 25. A connecting sleeve 12 is provided directly below the placement chamber. One ends of the multiple connecting plates 27 away from the rectangular blocks 30 are all hinged to the outer wall of the connecting sleeve 12. By pulling down the connecting sleeve 12, the four connecting plates 27 can be driven to rotate towards the approaching direction, so that the four rectangular blocks 30 can be driven to move towards the approaching direction inside the rectangular slots 25, and further drive the four moving plates 18 to move towards the approaching direction together, correcting the position of the culture dish placed inside the placement chamber, making the distance between the culture dish and the inner wall of the placement chamber constant, ensuring the air circulation and uniform temperature inside the device body 1, and facilitating the normal growth of mouse tumor cells.
[0030] As a technical optimization solution of the present invention, the driving mechanism includes multiple third chutes 5 opened on the inner walls of both sides of the device body 1. Multiple third sliders 6 are installed inside the multiple third chutes 5. One ends of the multiple third sliders 6 away from the third chutes 5 are jointly connected to a mounting plate 4. Multiple second linear motors are pre-installed inside the multiple third chutes 5. The multiple second linear motors can respectively drive the multiple third sliders 6 to move up and down inside the third chutes 5, so as to drive the mounting plate 4 to move up and down inside the device body 1.
[0031] As a technical optimization solution of the present invention, multiple through slots 7 are opened inside the mounting plate 4. Inside the multiple through slots 7, rotating blocks 13 with the same number as the placement chambers are rotatably installed. At the top ends of the multiple rotating blocks 13, third electric telescopic rods 8 are installed. The diameter of the third electric telescopic rods 8 is smaller than the inner diameter of the connecting sleeve 12. A driving device is pre-installed inside the mounting plate 4. The output end of the driving device is connected to the rotating part of the rotating block 13 and the through slot 7, so as to drive the rotating block 13 to rotate inside the through slot 7.
[0032] As a technical optimization solution of the present invention, rubber blocks 15 are installed at the telescopic ends of the multiple third electric telescopic rods 8. Two telescopic limiting rods 14 are installed inside the telescopic ends of the multiple third electric telescopic rods 8. The mounting plate 4 moves upward inside the device body 1, so as to drive the multiple third electric telescopic rods 8 to pass through the connecting sleeve 12 upward. Then, the telescopic ends of the two telescopic limiting rods 14 are controlled to extend. As the mounting plate 4 moves downward, the telescopic ends of the two telescopic limiting rods 14 can hinder the downward movement of the third electric telescopic rods 8 inside the connecting sleeve 12, so as to drive the connecting sleeve 12 to move downward together, achieving the effect of driving the multiple moving plates 18 to move towards the approaching direction described above.
[0033] In the present invention, when the user uses the device and needs to place a culture dish containing mouse tumor cells inside the device body 1 for culturing, after opening the sealing door 2 provided on the front of the device body 1, place the culture dish inside the corresponding placement groove 9 at the top of the placement rack 3. Control the telescopic ends of two corresponding second electric telescopic rods 22 to extend, driving two clamping plates 16 to move towards each other, clamping and fixing the culture dish inside the placement groove 9. Then, control two corresponding first sliders 21 to move inside the first chute 19, driving the clamped and fixed culture dish to move directly above the corresponding placement chamber. Control a plurality of third sliders 6 to move upward together inside the third chute 5, driving the mounting plate 4 and the corresponding third electric telescopic rod 8 at its top to move upward, so that the corresponding third electric telescopic rod 8 passes through the connecting sleeve 12 below the placement chamber and abuts against the bottom end of the round block 17. Control the telescopic end of the third electric telescopic rod 8 to extend, and the rubber block 15 that extends and contracts thereof pushes the round block 17 to move upward inside the placement chamber and contact the bottom end of the culture dish. Finally, control the telescopic ends of the two second electric telescopic rods 22 to drive the clamping plates 16 to retract and reset, so that the culture dish is placed on the top of the round block 17, and as the telescopic end of the third electric telescopic rod 8 contracts and resets downward, it drives the round block 17 to reset together, so that the culture dish is stably placed inside the placement chamber, achieving the effect of automatically placing the culture dish inside the device body 1; when multiple culture dishes need to be placed inside the device body 1 for culturing, the above steps can be repeated to place multiple culture dishes in sequence, without manually repeating the placement of multiple culture dishes, improving the efficiency of placing the culture dish inside the device body 1 and reducing the time of the culture dish in the external environment.
[0034] And when the culture dish inside the device body 1 needs to be taken out, the above steps can be repeated. With the telescopic end of the third electric telescopic rod 8 extending, the round block 17 and the culture dish are pushed to move upward inside the placement chamber to a specified height. Then, with the help of two first sliders 21, the clamping plates 16 are driven to move to both sides of the culture dish. After the two clamping plates 16 clamp and fix the culture dish, it is driven by the two first sliders 21 to move inside the placement groove 9 for placement. The staff can quickly take out the culture dish by opening the sealing door 2, reducing the contact time between the device body 1 and the external environment, thereby facilitating the culturing of mouse tumor cells by the device body 1 and improving the survival rate of mouse tumor cells.
[0035] At the same time, after the above-mentioned storage and retrieval mechanism places the culture dish inside the corresponding placement chamber, the telescopic end of the third electric telescopic rod 8 can be controlled to retract, but the third electric telescopic rod 8 is still located inside the connecting sleeve 12, and the two telescopic limit rods 14 at the telescopic end of the third electric telescopic rod 8 can be controlled to extend. In the process of the mounting plate 4 moving downward and resetting, the telescopic ends of the two telescopic limit rods 14 are both in contact with the top of the connecting sleeve 12, so that the third electric telescopic rod 8 cannot move downward smoothly inside the connecting sleeve 12, and can only drive the connecting sleeve 12 to move downward together. As the connecting sleeve 12 moves downward, the four connecting plates 27 are driven to rotate in the direction of approaching each other, so that the four rectangular blocks 30 can be driven in the rectangular groove. The inside of the plurality of electric telescopic rods 25 moves toward the approaching direction, driving the four movable plates 18 to move together in the approaching direction inside the placement chamber, correcting the position of the culture dish placed inside the placement chamber, and after the position of the culture dish is corrected, controlling the telescopic ends of the two telescopic limit rods 14 to retract, so that the connecting sleeve 12 is no longer controlled by the downward pulling force from the third electric telescopic rod 8, and driving the plurality of movable plates 18 to move and reset in the placement chamber by means of the elastic reset of the plurality of springs 28, avoiding the plurality of movable plates 18 from affecting the placement of the culture dish, making the distance between the culture dish and the inner wall of the placement chamber constant, ensuring the air circulation and uniform temperature of the culture dish inside the device body 1, and facilitating the normal growth of tumor cells inside the culture dish.
[0036] After the culture dish is placed inside the placement chamber, its position is corrected with the help of the correction mechanism, which can also facilitate the subsequent process of taking out the culture dish. In the process of the third electric telescopic rod 8 moving upward pushing the round block 17 to move upward together, the culture dish is located in the center of the top of the round block 17, so that the process of moving the culture dish upward is safer and more stable, which is convenient for the subsequent two clamps 16 to clamp and fix the culture dish quickly and accurately, thereby improving the safety of the process of taking out the culture dish.
[0037] After placing the multiple culture dishes in the multiple placement chambers in sequence, the multiple rotating blocks 13 inside the mounting plate 4 above the placement rack 3 can be controlled to rotate downward 180 degrees inside the through groove 7, driving the multiple third electric telescopic rods 8 to rotate downward to a vertical state, and then the multiple third sliding blocks 6 can be controlled to move downward together inside the third slide groove 5, driving the mounting plate 4 and the third electric telescopic rod 8 in a vertical state thereunder to move downward together, until the mounting plate 4 moves to a position close to the placement rack 3, and then the telescopic ends of the multiple third electric telescopic rods 8 are controlled to extend downward, driving the multiple rubber blocks 15 to contact the lid on the top of the culture dish, and the lid of the culture dish is pressed with the help of the downward moving rubber block 15 to ensure that the multiple culture dishes are in a sealed state in the placement chamber, avoiding the situation where the culture dish lid and the culture dish are not sealed tightly, resulting in a low survival rate of mouse tumor cells inside the culture dish.
[0038] Moreover, when multiple culture dishes are placed inside the device body 1 for culturing mouse tumor cells, the culture dishes are placed statically inside the device body 1. Prolonged stillness can cause the culture medium inside the culture dishes to precipitate or solidify, affecting the normal culture of mouse tumor cells. When it is found that the culture medium inside the culture dish shows precipitation, the mounting plate 4 under the multiple placement racks 3 can be controlled to move upward, driving the multiple third electric telescopic rods 8 to move upward and pass through the corresponding connecting sleeves 12. The telescopic ends of the third electric telescopic rods 8 located under the culture dish with precipitation are controlled to extend and retract upward, pushing the round block 17 and the culture dish on its top to move up and down inside the placement chamber, shaking the culture medium inside the culture dish, avoiding precipitation or solidification of the culture medium due to long-term static placement, and reducing the impact on the culture of mouse tumor cells.
[0039] If it is found that the growth of mouse tumor cells inside some culture dishes shows abnormal conditions, such as a large number of cell deaths or the growth of other bacteria inside the culture dishes, the above steps of taking out the culture dishes from the placement chamber can be repeated, and the culture dishes are placed inside the placement groove 9 for storage. After the staff opens the sealing door 2, the culture dishes with abnormal conditions can be observed in the first time and quickly taken out from the inside of the device body 1, improving the efficiency of dealing with the culture dishes with abnormal conditions; if there are a large number of culture dishes with abnormal conditions, after the first culture dish is placed inside the placement groove 9, after the two clamping plates 16 take out the subsequent culture dishes from the placement chamber, the telescopic ends of the two groups of corresponding first electric telescopic rods 20 can be controlled to extend upward, driving the two rectangular strip plates 10 and the clamping plates 16 to move upward together, so that the height of the culture dish clamped and fixed by the two clamping plates 16 at this time increases. As the two first sliders 21 drive the clamped culture dish to move towards the placement groove 9 inside the first chute 19, the subsequent culture dishes can move to the upper part of the first culture dish smoothly, and by controlling the telescopic ends of the two groups of first electric telescopic rods 20 to retract downward, the subsequent culture dishes are driven to be stacked on the upper part of the first culture dish, and the subsequent other culture dishes with abnormal conditions can be stacked and stored upward in turn.
[0040] After stacking multiple culture dishes with abnormal conditions above the placement rack 3, in order to prevent the stacked culture dishes from tilting and falling downward when the staff opens the sealing door 2, after stacking multiple culture dishes on the top of the placement rack 3, the mounting plate 4 located above the placement rack 3 can be controlled to move downward until the bottom end of the mounting plate 4 abuts against the top of the uppermost culture dish, so that the upper mounting plate 4 can press and fix the stacked culture dishes accordingly, avoiding the problem that the stacked culture dishes are easily damaged and improving the safety of the subsequent staff when taking the culture dishes with abnormal conditions.
[0041] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific embodiments described. Obviously, many modifications and variations can be made according to the content of this specification. These embodiments are selected and specifically described in this specification to better explain the principle and practical application of the present invention, so that those skilled in the art can understand and utilize the present invention well. The present invention is only limited by the claims and their full scope and equivalents.
Claims
1. A culture device for mouse tumor cells, comprising a device body (1), characterized in that, A sealing door (2) is installed on the front of the device body (1). A plurality of placement racks (3) are installed inside the device body (1). Placement grooves (9) for temporarily placing culture dishes are opened at the tops of the plurality of placement racks (3). An access mechanism for automatically picking up and placing culture dishes is provided inside each of the plurality of placement racks (3). The access mechanism includes a plurality of placement plates (11) installed inside the placement rack (3). Each of the plurality of placement plates (11) is divided into a plurality of placement chambers by a plurality of partition plates (23) provided therein. A calibration mechanism for calibrating the position of the culture dish is provided inside each of the plurality of placement chambers. Driving mechanisms for driving the calibration mechanism to work are provided on both the upper and lower sides of the plurality of placement racks (3) inside the device body (1).
2. The culture device for mouse tumor cells according to claim 1, wherein The access mechanism further includes two rectangular strip plates (10) provided above the plurality of placement plates (11). Two groups of first electric telescopic rods (20) are installed inside each of the plurality of placement plates (11). The telescopic ends of the two groups of first electric telescopic rods (20) are respectively connected to the rectangular strip plate (10) adjacent thereto.
3. The culture device for mouse tumor cells according to claim 2, characterized in that, First sliding grooves (19) are opened on the outer walls of the sides of the two rectangular strip plates (10) close to each other. First sliding blocks (21) are installed inside the two first sliding grooves (19). The ends of the two first sliding blocks (21) close to each other are both connected with clamping plates (16) for clamping and fixing the culture dish through second electric telescopic rods (22).
4. The culture device for mouse tumor cells according to claim 1, characterized in that, Circular grooves (24) are opened on the inner bottom surfaces of the plurality of placement chambers. Circular blocks (17) are placed inside the plurality of circular grooves (24).
5. The culture device for mouse tumor cells according to claim 1, wherein The calibration mechanism includes moving plates (18) provided on the four inner walls of the placement chamber. A plurality of second sliding grooves (26) are opened on the inner bottom surface of the placement chamber. Second sliding blocks (29) capable of moving back and forth in the second sliding grooves (26) are installed at the bottoms of the four moving plates (18).
6. The culture device for mouse tumor cells according to claim 5, characterized in that, A plurality of rectangular grooves (25) are further opened on the inner bottom surface of the placement chamber. Rectangular blocks (30) capable of sliding back and forth in the rectangular grooves (25) are installed at the bottoms of the four moving plates (18). Springs (28) are installed between the four rectangular blocks (30) and one inner wall of the rectangular grooves (25).
7. The culture device for mouse tumor cells according to claim 6, wherein, The bottoms of the four rectangular blocks (30) all pass through the rectangular grooves (25) and are rotatably installed with connecting plates (27). A connecting sleeve (12) is provided directly below the placement chamber. One ends of the plurality of connecting plates (27) far from the rectangular blocks (30) are all hinged to the outer wall of the connecting sleeve (12).
8. The culture device for mouse tumor cells according to claim 1, wherein The driving mechanism includes a plurality of third sliding grooves (5) opened on the inner walls of both sides of the device body (1). Third sliding blocks (6) are installed inside the plurality of third sliding grooves (5). One ends of the plurality of third sliding blocks (6) far from the third sliding grooves (5) are jointly connected with a mounting plate (4).
9. The culture device for mouse tumor cells according to claim 8, wherein, A plurality of through grooves (7) are opened inside the mounting plate (4). Rotating blocks (13) with the same number as the placement chambers are rotatably installed inside the plurality of through grooves (7). Third electric telescopic rods (8) are installed at the tops of the plurality of rotating blocks (13). The diameter of the third electric telescopic rod (8) is smaller than the inner diameter of the connecting sleeve (12).
10. The culture device for mouse tumor cells according to claim 9, characterized in that, Rubber blocks (15) are installed at the telescopic ends of multiple third electric telescopic rods (8), and two telescopic limit rods (14) are installed inside the telescopic ends of multiple third electric telescopic rods (8).
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