Preparation method of aminopyralid soluble liquid

By combining the modified chloropyrimidinic acid prodrug with carboxymethyl-β-cyclodextrin and guar gum, a stable inclusion compound is formed, which solves the storage stability and soil permeation and absorption of chloropyrimidinic acid soluble liquid, and achieves the controlled release performance and drug efficacy improvement under different pH environments.

CN120345580APending Publication Date: 2025-07-22SHOUJIAN TECH CO LTD
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Patent Information

Application Number
CN202510411519.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-02
Publication Date
2025-07-22

AI Technical Summary

Technical Problem

The existing chloropyrilyl acid-soluble liquid agents have shortcomings in storage stability and soil permeability, and have poor controlled release performance.

Method used

The chloropyrimidinic acid prodrug and carboxymethyl-β-cyclodextrin are formed, and the active ester intermediate is formed by chemical activation of N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarboimide, and covalently coated on the surface of the drug molecule with guar gum to form a modified chloropyrimidinic acid prodrug, and the addition of surfactants, dyes, antifreeze and preservatives are added to improve the wetting, permeability and stability of the solution.

Benefits of technology

The storage stability and soil permeability absorption performance of chloropyrilytic acid-soluble liquid agent are improved, the efficacy utilization rate is enhanced, and controlled release performance is achieved under different pH environments.

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Abstract

The invention discloses a preparation method of aminopyralid soluble liquid, and mainly relates to the technical field of herbicides. Compared with the prior art, the aminopyralid soluble liquid has the advantages that water-insoluble aminopyralid raw medicine is prepared into the soluble liquid, and the soluble liquid is in a molecular / ionic form in the solution after being diluted with water during use, so that medicine components have high penetrability and permeability, and the efficacy utilization rate is increased. Moreover, the problem of insufficient storage stability of aminopyralid is solved, and the aminopyralid dispersible tablet has good wetting and dispersing effects and permeation and absorption performance and has the characteristics of convenience in storage and use at an application end. Furthermore, aminopyralid is modified, and the storage stability, the soil permeation and absorption performance and the controlled release performance of the aminopyralid soluble liquid in practical application are improved at the same time.
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