Delivery device, delivery system and implant system

Abstract

The invention provides a conveying device, a conveying system and an implant system, the implant system comprises an implant and the conveying system, and the conveying system comprises a micro catheter and the conveying device. The conveying device comprises a conveying guide wire and a limiting pipe. The conveying guide wire comprises a guide wire body and a conveying element; the conveying element is fixed at the far end of the guide wire body, and the implant is sleeved, pressed and held on the conveying element; the limiting tube is arranged outside at least part of the conveying guide wire in a sleeving mode, and the far end of the limiting tube is used for at least wrapping the near end of the implant so as to limit the outer diameter of the near end of the implant. The conveying guide wire of the conveying device can have good force conductivity and flexibility so as to ensure smooth implantation of the stent. Meanwhile, the assembly mode of the conveying guide wire and the stent can prevent the stent from being disengaged from the micro-catheter when the stent moves, so that the stent is smoothly released, and the success rate of an operation is ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly to a delivery device, a delivery system and an implant system. Background Art

[0002] Intracranial aneurysms are mostly abnormal bulges occurring on the intracranial arterial vessel wall and are the leading cause of subarachnoid hemorrhage. In the prior art, an operator can treat by delivering a stent or a coil to the lesion site. During actual implantation, first, a microcatheter is delivered to the lesion site, and then the operator transports the implant in the body from the introducer sheath into the microcatheter through a delivery guide wire, and releases the stent by the cooperation of the delivery guide wire and the microcatheter to block and treat the aneurysm.

[0003] Currently, the delivery method of the implant is as follows: a delivery element is cooperated with the implant, and the stent is delivered through the frictional force between the delivery element and the implant. Among them, the assembly method between the implant and the delivery element can determine whether the implant can be successfully released. During the release process of the implant, if the implant does not accurately reach the lesion site, the operator needs to perform a recovery operation and re-release after adjusting the position. At this time, if the loading method of the implant is not good, there may be a risk that the frictional force between the implant and the delivery element is small, resulting in the implant being unloaded in the microcatheter. And after the implant reaches the lesion site and is released, if the loading method of the implant is not good, there may be a risk that the implant twists or deforms, resulting in the implant being unable to separate from the delivery guide wire, so that the implant cannot be completely released. If the advancing blood vessel is tortuous, during the delivery process of the implant or when the implant is released, the operator may have difficulty in operating due to excessive pushing resistance, and the surgical effect cannot be guaranteed.

[0004] Therefore, there is an urgent need to design a delivery device that can enable the implant to have good anti-unloading and release properties and can reduce the pushing resistance during the pushing process of the implant. Summary of the Invention

[0005] The purpose of the present invention is to provide a delivery device, a delivery system and an implant system. The delivery guide wire of the delivery device can have good force conductivity and flexibility to ensure the smooth implantation of the stent. At the same time, the assembly method of the delivery guide wire and the stent can also prevent the stent from being unloaded in the microcatheter when the stent moves, thereby realizing the smooth release of the stent and ensuring the success rate of the operation.

[0006] To achieve the above object, the present invention provides a delivery device for delivering an implant to a predetermined position, comprising a delivery guide wire and a limiting tube; the delivery guide wire includes a guide wire body and a delivery element; the delivery element is fixed to the distal end of the guide wire body, and the implant is sleeved and crimped on the delivery element; the limiting tube is sleeved outside at least a part of the delivery guide wire, and the distal end of the limiting tube is used to at least cover the proximal end of the implant to define the outer diameter of the proximal end of the implant.

[0007] Optionally, the delivery guide wire is connected to the limiting tube to drive the limiting tube and the implant to move synchronously; the limiting tube is made of a degradable material so that after the limiting tube degrades, the restraint on the implant is released, and thus the implant expands.

[0008] Optionally, the degradable material includes one or a combination of sugars, polyethylene glycol, polyethylene oxide, polyvinyl alcohol, polylactic acid, polyglycolic acid, polylactic acid-glycolic acid.

[0009] Optionally, when delivering the implant, the delivery guide wire is connected to the limiting tube to drive the limiting tube and the implant to move synchronously; after the implant is delivered to the predetermined position, the delivery guide wire is separated from the limiting tube, and the delivery guide wire is further used to drive the implant to move relative to the limiting tube after separation until the implant extends out of the distal end of the limiting tube.

[0010] Optionally, the outer diameter of the delivery guide wire gradually decreases from the proximal end to the distal end in its own extension direction, and the maximum outer diameter of the delivery guide wire matches the inner diameter of the limiting tube; the delivery guide wire is connected to the limiting tube at the part with the maximum outer diameter, and the length of the connection position between the delivery guide wire and the limiting tube in the extension direction of the delivery guide wire is 1 mm to 10 mm.

[0011] Optionally, when delivering the implant, the delivery guide wire and the limiting tube are fixedly bonded with glue; after the implant is delivered to the predetermined position, a dissolving solution is used to be injected into the gap between the delivery guide wire and the limiting tube, and the dissolving solution is used to dissolve the glue so that the delivery guide wire is separated from the limiting tube.

[0012] Optionally, a stop member protruding outward is provided at the proximal end of the delivery element, the implant is used to be crimped on the distal end of the stop member, and the stop member is used to prevent the implant from moving proximally relative to the delivery element.

[0013] Optionally, the stop member is formed by protruding radially outward along the guide wire body at the proximal end of the delivery element.

[0014] Optionally, the conveying element is made of a polymer material, and the conveying element can deform and reduce its outer diameter after the implant is crimped; after the implant is crimped, it covers a part of the area of the conveying element, and the part of the area of the conveying element not crimped by the implant forms the stop.

[0015] Optionally, the proximal end of the implant and the proximal end of the conveying element are spaced a predetermined distance on the axis of the guide wire body; the predetermined distance accounts for 20% to 60% of the total length of the conveying element.

[0016] Optionally, the number of the conveying elements is multiple, and the multiple conveying elements are sequentially spaced along the extension direction of the guide wire body, and the outer diameter of each conveying element is larger than the outer diameter of the guide wire body at the adjacent position.

[0017] Optionally, the proximal end of the delivery guide wire extends out of the proximal end of the limiting tube; in the extension direction of the delivery guide wire, the length that the delivery guide wire extends out of the limiting tube is greater than the length that the limiting tube covers the implant.

[0018] Optionally, in the extension direction of the delivery guide wire, the length of the implant crimped on the conveying element accounts for 20% to 50% of the total length of the implant.

[0019] Optionally, in the extension direction of the delivery guide wire, the length of the limiting tube covering the implant accounts for 20% to 100% of the total length of the implant.

[0020] To achieve the above object, the present invention also provides a delivery system, including a microcatheter and the delivery device according to any one of the above, when delivering the implant, the microcatheter is used to sleeve the outside of the delivery device and the implant, and is used to move together with the delivery device and the implant to the predetermined position; after the implant reaches the predetermined position, it is used to move out of the distal end of the microcatheter under the drive of the delivery device.

[0021] To achieve the above object, the present invention also provides an implant system, including an implant and the delivery system, the delivery system is used to deliver the implant to a predetermined position, and is used to drive the implant to be released at the predetermined position.

[0022] The present invention provides a delivery device for delivering an implant to a predetermined position, which includes a delivery guide wire and a limiting tube; the delivery guide wire includes a guide wire body and a conveying element; the conveying element is fixed at the distal end of the guide wire body; the implant is sleeved and crimped on the conveying element; the limiting tube is sleeved outside at least part of the delivery guide wire, and the distal end of the limiting tube is used to cover at least the proximal end of the implant to define the proximal outer diameter of the implant.

[0023] With such a configuration, the conveying device can restrain the proximal end of the implant through the limiting tube, increasing the gap between the implant and the microcatheter. At the same time, it also reduces the force exerted by the self-expansion of the implant on the inner wall of the microcatheter, thereby reducing the pushing resistance of the implant relative to the microcatheter during movement.

[0024] In addition, due to the restraint of the proximal end of the implant by the limiting tube, the friction between the implant and the conveying wire after the implant is crimped on the conveying wire is increased. Therefore, the risk of the implant being unloaded from the microcatheter during movement can be reduced, the anti-unloading property and release property of the implant can be improved, and the risk of the implant deforming during conveying can also be reduced, which helps the implant to reach the lesion site smoothly and be accurately released, improving the success rate of the operation. Brief Description of the Drawings

[0025] Figure 1 It is a schematic structural diagram of the conveying wire and the implant in a preferred embodiment of the present invention, wherein the implant is crimped on the conveying element.

[0026] Figure 2 It is a schematic structural diagram of the conveying wire in a preferred embodiment of the present invention;

[0027] Figure 3 It is a schematic structural diagram of the implant and a part of the conveying system in a preferred embodiment of the present invention;

[0028] Figure 4 It is a schematic structural diagram of the implant and a part of the conveying system in another preferred embodiment of the present invention.

[0029] In the figure: implant 10; conveying wire 1; wire body 11; imaging element 111; conveying element 12; handle 13; strengthening tube 14; stop member 121; limiting tube 2; microcatheter 3; inner cavity 31. Detailed Description of the Embodiment

[0030] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. According to the following description, the advantages and features of the present invention will be clearer. It should be noted that the accompanying drawings are all in a very simplified form and use non-precise scales, only for conveniently and clearly assisting in explaining the purpose of the embodiments of the present invention.

[0031] The terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. They are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present invention.

[0032] As used in this specification, the "distal end" generally refers to the end of the delivery device that is far from the operator; the term "proximal end" is opposite to the "distal end" and generally refers to the end of the delivery device that is close to the operator; the term "axial direction" refers to the extension direction of the axis of the implant, that is, the moving direction of the delivery guide wire.

[0033] In the present invention, unless otherwise clearly defined and limited, the terms such as "installation", "connection", "fixation", etc. should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection, an electrical connection, or communicable with each other; it can be directly connected, or connected through an intermediate medium, and can be the internal communication of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0034] The following will describe the exemplary embodiments of the present application in detail with reference to the drawings. Without conflict, the following embodiments and the features in the embodiments can be mutually supplemented or combined.

[0035] As Figure 1 and Figure 2 As shown, a preferred embodiment of the present invention provides a delivery device for delivering the implant 10 to a predetermined position. Specifically, the delivery device is used to deliver the implant 10 to the diseased part of the blood vessel, and then the delivery device is also used to assist the implant 10 to be released at the diseased part, so that the implant 10 is anchored on the inner wall of the diseased blood vessel, thereby achieving the purpose of treating diseases.

[0036] Referring to Figure 3 and Figure 4As shown in the figure, a preferred embodiment of the present invention further provides a delivery system, which includes a delivery device and a microcatheter 3. When delivering the implant 10, the microcatheter 3 is used to sleeve the outside of the delivery device and the implant 10, and the implant 10 and the delivery guide wire 1 are movably arranged inside the microcatheter 3. The microcatheter 3 is used to move together with the delivery device and the implant 10 to a predetermined position. After the implant 10 reaches the predetermined position, the delivery device is used to drive the implant 10 out of the distal end of the microcatheter 3.

[0037] It should be understood that the predetermined position refers to the diseased part of the blood vessel, and the implant 10 is used to anchor at the diseased part to achieve the purpose of treatment.

[0038] It should be noted that the delivery system needs to have good flexibility and force transmission, so that the delivery system will not bend or knot when delivering in tortuous blood vessels. The force transmission refers to the ability of the delivery system to deliver the implant 10 to the diseased part.

[0039] A preferred embodiment of the present invention further provides an implant system, which includes an implant 10 and a delivery system. The delivery system is used to deliver the implant 10 to a predetermined position and to drive the implant 10 to be released at the predetermined position.

[0040] Referring to Figures 1 to 3 As shown in the figure, the delivery device includes a delivery guide wire 1 and a limiting tube 2. The delivery guide wire includes a guide wire body 11 and a delivery element 12, and the delivery element 12 is fixed at the distal end of the guide wire body 11. Among them, the delivery element 12 can be integrally formed with the guide wire body 11, and at the same time, the delivery element 12 can also be connected after being separately formed from the guide wire body 11.

[0041] Furthermore, the implant 10 is sleeved and crimped on the delivery element 12. The limiting tube 2 is sleeved on the outside of at least part of the delivery guide wire 1, that is, the delivery guide wire 1 penetrates through the limiting tube 2. The distal end of the limiting tube 2 is used to at least cover the proximal end of the implant 10 to define the outer diameter of the proximal end of the implant 10. That is to say, the limiting tube 2 is used to at least sleeve the proximal end of the delivery element 12 on which the implant 10 has been crimped. At this time, the implant 10 is located between the limiting tube 2 and the delivery element 12.

[0042] During the actual implantation of the delivery system, first, the delivery device and the implant 10 are slidably sleeved inside an introducer sheath (not shown). The introducer sheath is docked with the microcatheter 3 during the operation. The operator pushes the delivery guide wire 1 to push the implant 10 into the microcatheter 3. The delivery guide wire 1 is delivered to the diseased part of the blood vessel (i.e., the predetermined position) through the microcatheter 3. Then, the operator drives the implant 10 to move relative to the microcatheter 3 through the delivery guide wire 1 until the implant 10 extends out of the distal end of the microcatheter 3 and is released.

[0043] As a preferred embodiment, when delivering the implant 10, the limiting tube 2 can be connected to the delivery guide wire 1 by adhesion or other means. The delivery guide wire 1 is used to drive the implant 10 and the limiting tube 2 to move synchronously. After the implant 10 is delivered to the predetermined position, the operator can push the delivery guide wire 1 in the direction from the proximal end to the distal end of the delivery guide wire 1. The delivery guide wire 1 can drive the implant 10 to move until the implant 10 extends out of the microcatheter 3, so that the implant 10 is released after being exposed at the lesion site.

[0044] It should be noted that the implant 10 refers to a component that can be implanted into the lesion site of a blood vessel to treat diseases, such as a stent or a coil. The implant 10 can have good self-expanding performance and radial supporting force. At the same time, the implant 10 can also be compressed and held on the delivery element 12 and placed in the microcatheter 3. When the microcatheter 3 moves to the lesion site, the implant 10 can extend out of the microcatheter 3 and expand (i.e., dilate) under the drive of the guide wire body 11. After the implant 10 expands, it can be anchored to the inner wall of the blood vessel to treat diseases.

[0045] In one example, the limiting tube 2 only sleeved and covered the outer surface of the proximal end of the implant 10; in another example, the limiting tube 2 sleeved and covered all the outer surfaces of the implant 10 except the distal end; in still another example, the limiting tube 2 can also sleeve and cover all the outer surfaces of the implant 10.

[0046] Furthermore, there is friction between the implant 10 and the delivery element 12. When the delivery guide wire 1 moves in the blood vessel, the delivery element 12 can drive the implant 10 to move until the implant 10 is released by relying on the friction force.

[0047] Since the self-expanding action of the implant 10 in the microcatheter 3 will squeeze the inner wall of the microcatheter 3, the pushing resistance of the implant 10 in the microcatheter 3 is increased. Designing to sleeve the limiting tube 2 on the proximal end of the implant 10 can reduce the outer diameter of the proximal end of the implant 10. In this way, the proximal end of the implant 10 can be restricted by the limiting tube 2, increasing the gap between the implant 10 and the microcatheter 3. At the same time, the force of the implant 10 squeezing the inner wall of the microcatheter 3 due to self-expanding action can also be reduced. Therefore, the pushing resistance of the implant 10 moving relative to the microcatheter 3 can be reduced.

[0048] At the same time, due to the restriction of the proximal end of the implant 10 by the limiting tube 2, the friction force between the implant 10 and the delivery guide wire 1 after the implant 10 is compressed and held on the delivery guide wire 1 is increased. The risk of the implant 10 being unloaded from the microcatheter 3 during movement can be reduced, the anti-unloading property and release property of the implant 10 can be improved, and the risk of the implant 10 deforming during delivery can also be reduced, which helps the implant 10 to reach the lesion site smoothly and be accurately released, improving the success rate of the operation.

[0049] In addition, since the implant 10 is usually set as a stent or a coil, the outer surface of the implant 10 is usually relatively rough. While the outer peripheral surface of the limiting tube 2 is usually relatively smooth, that is, the roughness is relatively low. In the present invention, the limiting tube 2 is sleeved outside the implant 10. Since the outer surface of the limiting tube 2 is usually smoother than the outer surface of the implant 10, when the implant 10 contacts the microcatheter 3 through the limiting tube 2, the implant 10 has a smaller frictional force, which helps to reduce the pushing resistance of the implant 10 when the implant 10 contacts the microcatheter 3 through the limiting tube 2 with a smooth outer surface, and improves the operability of the doctor.

[0050] This application does not limit the connection manner between the implant 10 and the delivery element 12. The delivery element 12 can be connected to the implant 10 by means such as welding or bonding.

[0051] This application does not limit the preparation material of the implant 10. The preparation materials of the implant 10 include but are not limited to nitinol and cobalt-chromium alloy, etc. The implant 10 can be prepared by means of winding, cutting or weaving, and the implant 10 itself can have a radiopaque function.

[0052] This application does not limit the preparation material of the limiting tube 2. The preparation materials of the limiting tube 2 include but are not limited to metal materials or polymer materials. Among them, the metal materials can include stainless steel and nitinol, etc., and the polymer materials can include PTFE (polytetrafluoroethylene), etc. In addition, considering the compliance of the limiting tube 2 during delivery, the hardness of the limiting tube 2 does not need to be too large.

[0053] To ensure that the delivery guide wire 1 can deliver the implant 10 in place, the proximal end of the delivery guide wire 1 extends out of the proximal end of the limiting tube 2, and in the extending direction of the delivery guide wire 1, the length that the delivery guide wire 1 extends out of the limiting tube 2 is greater than the length that the limiting tube 2 covers the implant 10. In this way, it can be ensured that the implant 10 can completely move out of the limiting tube 2 when the implant 10 moves relative to the delivery guide wire 1, so as to facilitate the complete release of the implant 10.

[0054] In a preferred embodiment, the delivery guide wire 1 is connected to the limiting tube 2 to drive the limiting tube 2 and the implant 10 to move synchronously until the implant 10 and the limiting tube 2 synchronously extend out of the microcatheter 3. The limiting tube 2 is made of a biodegradable material, so that after the limiting tube 2 degrades, the restraint on the implant 10 is released, and then the implant 10 expands. Specifically, after the implant 10 and the limiting tube 2 move and are exposed at a predetermined position, the limiting tube 2 can be degraded (that is, the limiting tube 2 can dissolve in the blood). The implant 10 is used to break away from the restraint of the limiting tube 2 and expand after the limiting tube 2 degrades. In other words, the implant 10 can be anchored in the blood vessel wall at the lesion site after the limiting tube 2 dissolves, so as to realize the release of the implant 10 at the lesion site.

[0055] Preferably, the degradable material can be set as a polymer shell or film, specifically including one or a combination of sugars, polyethylene glycol, polyethylene oxide, polyvinyl alcohol, polylactic acid, polyglycolic acid, polylactic acid-glycolic acid, etc. The limiting tube 2 arranged in this way can be gradually dissolved when exposed to the inside of the blood vessel.

[0056] Since it takes a certain amount of time for the limiting tube 2 to dissolve in the blood, after the limiting tube 2 and the implant 10 are removed from the microcatheter 3, if the positioning of the implant 10 is inaccurate, the implant 10 can still be retrieved into the microcatheter 3 and released after repositioning.

[0057] In another preferred embodiment, when delivering the implant 10, the delivery guide wire 1 is connected to the limiting tube 2 to drive the limiting tube 2 and the implant 10 to move synchronously. After the implant 10 is delivered to the predetermined position, the delivery guide wire 1 is separated from the limiting tube 2, and the delivery guide wire 1 is also used to drive the implant 10 to move relative to the limiting tube 2 after separation until the implant 10 extends out of the distal end of the limiting tube 2. After the implant 10 moves to the diseased part and is released, the operator can withdraw the microcatheter 3, the delivery guide wire 1 and the limiting tube 2 together out of the body, and only retain the implant 10 in the blood vessel for the treatment of the disease.

[0058] Return to reference Figure 1 and Figure 2 As shown in the figure, in a schematic embodiment, the outer diameter of the delivery guide wire 1 gradually decreases from the proximal end to the distal end in its own extension direction, and the maximum outer diameter of the delivery guide wire 1 matches the inner diameter of the limiting tube 2.

[0059] It should be explained that the part with the maximum outer diameter of the delivery guide wire 1 is preferably distributed in the proximal region of the delivery guide wire 1. In this case, since the outer diameter of the distal end of the delivery guide wire 1 is relatively small, there is a certain gap between the distal end of the delivery guide wire 1 and the distal end of the limiting tube 2, and the size of this gap should be larger than the wall thickness of the implant 10 so as to press the proximal end of the implant 10 between the delivery guide wire 1 and the limiting tube 2.

[0060] Preferably, the delivery guide wire 1 is connected to the limiting tube 2 at the part with the maximum outer diameter, and the connection position of the delivery guide wire 1 and the limiting tube 2 has a length of 1 mm to 10 mm in the extension direction of the delivery guide wire 1. The connection position of the delivery guide wire 1 and the limiting tube 2 can be set at the proximal end, middle or distal end of the part with the maximum outer diameter of the delivery guide wire.

[0061] This application does not limit the fixing method of the delivery guide wire 1 and the limiting tube 2. For example, when delivering the implant 10, the delivery guide wire 1 and the limiting tube 2 can be fixedly bonded with glue, that is, the limiting tube 2 is bonded to the delivery guide wire 1 so that there is no relative movement between the delivery guide wire 1 and the limiting tube 2. After the implant 10 is delivered to the predetermined position, a dissolving solution is injected into the gap between the delivery guide wire 1 and the limiting tube 2, and the dissolving solution is used to dissolve the glue so that the delivery guide wire 1 and the limiting tube 2 are separated, realizing the movement of the delivery guide wire 1 relative to the limiting tube 2.

[0062] In a specific embodiment, a Luer connector is provided at the proximal end of the limiting tube 2, and the delivery guide wire 1 is inserted through the Luer connector. After the implant 10 reaches the lesion site, the operator can inject normal saline (i.e., the dissolving solution) into the gap between the delivery guide wire 1 and the limiting tube 2 through the Luer connector, so that the glue between the delivery guide wire 1 and the limiting tube 2 is dissolved, and the delivery guide wire 1 and the limiting tube 2 are separated. Then, the operator can fix the position of the limiting tube 2 and at the same time push the delivery guide wire 1 in the direction from the proximal end to the distal end to push the implant 10 out of the microcatheter 3 for release. Further, in the extending direction of the delivery guide wire 1, the length of the limiting tube 2 covering the implant 10 accounts for 20% - 100% of the total length of the implant 10 to meet the requirement that the limiting tube 2 can fully limit the proximal outer diameter of the implant 10. Preferably, the length of the limiting tube 2 covering the implant 10 accounts for a proportion close to 100% of the total length of the implant 10, further reducing the pushing resistance of the implant 100.

[0063] Refer to Figure 3 As shown, in an alternative example, after the implant 10 is crimped on the delivery element 12, the proximal end of the delivery element 12 is aligned with the proximal end of the implant 10 in the radial direction of the delivery guide wire 1, and the distal end of the delivery element 12 is located inside the implant 10. At this time, the delivery guide wire 1 drives the implant 10 to move only through the frictional force between the delivery element 12 and the implant 10.

[0064] Refer to Figure 4 As shown, a stop member 121 protruding outward is preferably provided at the proximal end of the delivery element 12, and the implant 10 is used to be crimped at the distal end of the stop member 121, that is, the implant 10 is crimped in the distal region of the stop member 121 in the delivery element 12. Among them, the stop member 121 can be integrally formed with the delivery element 12 or can be connected after being separately formed from the delivery element 12. The stop member 121 is used to prevent the implant 10 from moving proximally relative to the delivery element 12 to prevent the implant 10 from being unloaded during pushing. It should be understood that the direction of the delivery element 12 facing outward refers to the direction from the inside of the delivery element 12 towards the direction away from the delivery element.

[0065] In a preferred case, the stopper 121 is in contact with the implant 10. At this time, the stopper 121 is also used to push the implant 10, and the implant 10 can move relative to the microcatheter 3 under the combined action of the frictional force between the implant 10 and the delivery element 12 and the pushing force of the stopper 121.

[0066] This application does not limit the preparation material of the delivery element 12. The delivery element 12 can be set as a hard material or a soft material. Among them, the hard materials include but are not limited to metal materials or high-molecular materials with a relatively high hardness, and the soft materials include but are not limited to high-molecular materials with a relatively low hardness.

[0067] As Figure 4 shown, in some embodiments, the proximal end of the delivery element 12 protrudes radially outward along the guide wire body 11 to form a stopper 121. At this time, the stopper 121 is integrally formed with the delivery element 12, and the outer peripheral surface of the stopper 121 protrudes radially along the delivery element 12 beyond the outer peripheral surface of the delivery element 12. In this case, the delivery element 12 can be made of a hard material or a soft material.

[0068] In other embodiments, the delivery element 12 can be made of a high-molecular material. The delivery element 12 can deform and reduce its outer diameter after the implant 10 is crimped. For example, the delivery element 12 can be made of a soft and easily deformable material. After the implant 10 is crimped, it covers a part of the area of the delivery element 12, and the part of the area of the delivery element 12 that is not crimped by the implant 10 forms a stopper 121.

[0069] More specifically, the proximal end of the implant 10 and the proximal end of the delivery element 12 can be spaced a predetermined distance on the axis of the guide wire body 11, and the proximal end of the implant 10 is located on the outer peripheral surface of the delivery element 12. At this time, after the implant 10 is crimped on the delivery element 12, since the part of the delivery element 12 that is crimped by the implant 10 deforms and reduces its outer diameter, the outer diameter of the part of the proximal end of the delivery element 12 that is not crimped by the implant 10 is greater than the outer diameter of the part of the delivery element 12 that is compressed by the implant 10. At this time, the part of the proximal end of the delivery element 12 that is not crimped by the implant 10 forms a stopper 121, thereby assisting in pushing the implant 10 to a predetermined position and preventing the implant 10 from being unloaded during pushing.

[0070] Preferably, the predetermined distance between the implant 10 and the delivery element 12 accounts for 20% - 60% of the total length of the delivery element 12 (that is, the length of the delivery element 12 in the extending direction of the guide wire body 11). That is to say, the implant 10 is only compressed on the 40% - 80% area at the distal end of the delivery element 12. This can ensure that the implant 10 and the delivery element 12 have a sufficient contact area, so that there is an appropriate frictional force between the delivery element 12 and the implant 10.

[0071] Further, in the extending direction of the delivery guide wire 1, the length of the implant 10 pressed and held on the delivery element 12 accounts for 20% to 50% of the total length of the implant 10. In this way, not only can there be sufficient frictional force between the delivery element 12 and the implant 10, but also the distal end of the implant 10 can be prevented from contacting the delivery element 12 to facilitate the expansion of the implant 10.

[0072] In a preferred case, the number of delivery elements 12 is multiple. The multiple delivery elements 12 are arranged at intervals in the extending direction of the guide wire body 11. The outer diameter of each delivery element 12 is greater than the outer diameter of the guide wire body 11 at the adjacent position, that is, the outer peripheral surface of the delivery element 12 protrudes radially from the outer peripheral surface of the guide wire body 11, so as to ensure that the implant 10 does not interfere with the guide wire body 11 after being pressed and held on the delivery element 12.

[0073] Preferably, the implant 10 can be pressed and held on the area of the proximal-most delivery element 12 except the proximal end. In this way, a stop 121 can be provided at the proximal end of the proximal-most delivery element 12 to prevent the implant 10 from being unloaded.

[0074] This application does not limit the number of delivery elements 12. The number of delivery elements 12 can be set to one or more. For example, the delivery element 12 can be set to Figure 3 3 in

[0075] This application also does not limit the shape of the delivery element 12. Referring to Figure 2 As shown, in one example, the delivery element 12 is a cylindrical structure, and the outer diameter of the delivery element 12 is preferably slightly greater than the outer diameter of the guide wire body 11 at the adjacent position. In another example, the delivery element 12 is a frustum-shaped structure, and the outer diameter of the proximal end of the delivery element 12 is greater than the outer diameter of the distal end of the delivery element 12. The outer diameter of the proximal end or the distal end of the delivery element 12 is preferably slightly greater than the outer diameter of the guide wire body 11 at the adjacent position.

[0076] More specifically, the microcatheter 3 has a lumen 31 (refer to Figure 3 ), and the delivery device for loading the implant 10 can be movably placed in the lumen 31. The delivery device is used to drive the implant 10 to extend out of the lumen 31 of the microcatheter 3 for release.

[0077] In a preferred solution, the microcatheter 3 includes an inner layer, an outer layer, a diffusion stress tube and a connection port. Among them, the outer layer is placed outside the inner layer. Both the inner layer and the outer layer can be set as a single-layer structure or a multi-layer structure, and the inner layer has a lumen 31. At least one imaging ring is sleeved on the distal end of the inner layer. It should be known that the preparation materials of the imaging ring include but are not limited to platinum, iridium, tantalum and noble metal alloys, etc.

[0078] In a specific example, a radiopaque ring is sleeved at the distal end of the inner layer, and at least one radiopaque ring can be sleeved at other positions of the inner layer except the distal position.

[0079] It should be noted that the materials for preparing the inner layer and the outer layer of the microcatheter 3 can include one or a combination of several materials such as nylon elastomer Pebax, nylon, polyurethane PU, polytetrafluoroethylene PTFE, high-density polyethylene HDPE, Pebax mixed with additives for reducing the friction coefficient, or polyolefin elastomer, etc., but should not be limited thereto. The inner layer and the outer layer of the microcatheter 3 can further include a hollow structure prepared by materials such as stainless steel, nitinol alloy, cobalt-chromium alloy, or polymer filaments through weaving, spiraling, or cutting, etc.

[0080] Returning to the reference Figure 1 , the delivery guide wire 1 further includes a handle 13. The handle 13 is connected to the guide wire body 11 at the proximal end of the guide wire body 11. The operator controls the movement of the guide wire body 11 in the blood vessel by operating the handle 13. Since the distal end of the guide wire body 11 often needs to have a certain strength and hardness to improve the force conductivity of the delivery guide wire 1 and ensure that the operating handle 13 can smoothly deliver the guide wire body 11 to the predetermined position.

[0081] Continuing to refer to Figure 1 , in a schematic embodiment, the delivery guide wire 1 further includes a reinforcing tube 14. The reinforcing tube 14 is sleeved outside the guide wire body 11 and is located in the region between the delivery element 12 and the handle 13. The reinforcing tube 14 includes but is not limited to a cut hypotube and a stepped spring. The materials for preparing the reinforcing tube 14 include but are not limited to stainless steel and nitinol alloy, etc. At the same time, the fixing method of the reinforcing tube 14 to the guide wire body 11 can be set as glue bonding, laser welding, resistance welding, or pulse welding, etc.

[0082] Since the distal end of the delivery system should have flexibility and radiopacity, it can avoid damaging the patient's blood vessels during the process of delivering the implant 10, and at the same time, it can also facilitate the doctor to timely know the specific position of the delivery system during delivery for the next operation.

[0083] In an example, a radiopaque member 111 (not shown) can be installed at the position corresponding to the middle part of the implant 10 of the delivery element 12, and another radiopaque member 111 can be installed at the position corresponding to the proximal end of the implant 10 of the delivery element 12 (refer to Figure 1 ). The materials for preparing the radiopaque member 111 include but are not limited to platinum, iridium noble metal alloys, etc.

[0084] In summary, the present invention provides a delivery device, a delivery system and an implant system. The delivery device can restrain the proximal end of the implant 10 through the limiting tube 2, increasing the gap between the implant 10 and the microcatheter 3. At the same time, it also reduces the force exerted by the self-expansion of the implant 10 on the inner wall of the microcatheter 3, thereby reducing the pushing resistance of the implant 10 relative to the microcatheter 3 during movement.

[0085] In addition, due to the restraint of the proximal end of the implant 10 by the limiting tube 2, the friction between the implant 10 and the delivery guide wire 1 is increased after the implant 10 is crimped on the delivery guide wire 1. Therefore, the risk of the implant 10 being unloaded from the microcatheter 3 during movement can be reduced, the anti-unloading property and release property of the implant 10 can be improved, and the risk of deformation of the implant 10 during delivery can also be reduced, which helps the smooth release and accurate positioning of the implant 10 and improves the success rate of the operation.

[0086] The above description is only a description of the preferred embodiments of the present invention and does not limit the scope of the present invention in any way. Any changes and modifications made by those of ordinary skill in the art of the present invention based on the above disclosure shall fall within the protection scope of the present invention.

Claims

1. A delivery device for delivering an implant to a predetermined position, characterized in that, It includes a delivery guide wire and a limiting tube; the delivery guide wire includes a guide wire body and a delivery element; the delivery element is fixed at the distal end of the guide wire body, and the implant is sleeved and crimped on the delivery element; the limiting tube is sleeved outside at least part of the delivery guide wire, and the distal end of the limiting tube is used to at least cover the proximal end of the implant to define the proximal outer diameter of the implant.

2. The conveying device according to claim 1, characterized in that, The delivery guide wire is connected to the limiting tube to drive the limiting tube and the implant to move synchronously; the limiting tube is made of a degradable material so that after the limiting tube degrades, the restraint on the implant is released, and then the implant expands.

3. The conveying device according to claim 2, characterized in that, The degradable material includes one or a combination of sugars, polyethylene glycol, polyethylene oxide, polyvinyl alcohol, polylactic acid, polyglycolic acid, polylactic acid-glycolic acid, etc.

4. The conveying device according to claim 1, characterized in that, When delivering the implant, the delivery guide wire is connected to the limiting tube to drive the limiting tube and the implant to move synchronously; after the implant is delivered to the predetermined position, the delivery guide wire is separated from the limiting tube, and the delivery guide wire is also used to drive the implant to move relative to the limiting tube after separation until the implant extends out of the distal end of the limiting tube.

5. The conveying device according to claim 2 or 4, characterized in that, The outer diameter of the delivery guide wire gradually decreases from the proximal end to the distal end in its own extension direction, and the maximum outer diameter of the delivery guide wire matches the inner diameter of the limiting tube; the delivery guide wire is connected to the limiting tube at the part with the maximum outer diameter, and the length of the connection position between the delivery guide wire and the limiting tube in the extension direction of the delivery guide wire is 1 mm to 10 mm.

6. The conveying device according to claim 2 or 4, characterized in that, When delivering the implant, the delivery guide wire and the limiting tube are fixedly bonded with glue; after the implant is delivered to the predetermined position, a dissolving solution is used to be injected into the gap between the delivery guide wire and the limiting tube, and the dissolving solution is used to dissolve the glue so that the delivery guide wire is separated from the limiting tube.

7. The conveying device according to any one of claims 1-4, characterized in that, A stop member protruding outward is provided at the proximal end of the delivery element, the implant is used to be crimped at the distal end of the stop member, and the stop member is used to prevent the implant from moving proximally relative to the delivery element.

8. The conveying device according to claim 7, wherein The proximal end of the delivery element protrudes radially outward along the guide wire body to form the stop member.

9. The conveying device according to claim 7, wherein, The delivery element is made of a polymer material, and the delivery element can deform and reduce its outer diameter after the implant is crimped; after the implant is crimped, it covers a part of the area of the delivery element, and the part of the area of the delivery element not covered by the implant forms the stop member.

10. The conveying device according to claim 9, characterized in that, The proximal end of the implant and the proximal end of the delivery element are spaced a predetermined distance on the axis of the guide wire body; the predetermined distance accounts for 20% to 60% of the total length of the delivery element.

11. The conveying device according to any one of claims 1 to 4, characterized in that, The number of the delivery elements is multiple, and the multiple delivery elements are sequentially spaced along the extension direction of the guide wire body, and the outer diameter of each delivery element is larger than the outer diameter of the adjacent guide wire body.

12. The conveying device according to any one of claims 1-4, characterized in that, The proximal end of the delivery guide wire extends out of the proximal end of the limiting tube; in the extension direction of the delivery guide wire, the length that the delivery guide wire extends out of the limiting tube is greater than the length that the limiting tube covers the implant.

13. The conveying device according to any one of claims 1-4, characterized in that, In the extending direction of the delivery guide wire, the length of the implant compressed and held on the delivery element accounts for 20% to 50% of the total length of the implant.

14. The conveying device according to any one of claims 1-4, characterized in that, In the extending direction of the delivery guide wire, the length of the limiting tube covering the implant accounts for 20% to 100% of the total length of the implant.

15. A conveying system, characterized in that, Comprising a microcatheter and the delivery device according to any one of claims 1-14, during the delivery of the implant, the microcatheter is used to sleeved outside the delivery device and the implant, and is used to move together with the delivery device and the implant to the predetermined position; after the implant reaches the predetermined position, the delivery device is used to drive the implant out of the distal end of the microcatheter.

16. An implant system, characterized in that, Comprising an implant and the delivery system according to claim 15, the delivery system is used to deliver the implant to a predetermined position and to drive the implant to be released at the predetermined position.

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