Preparation of nano composite hydrogel and application of nano composite hydrogel in acceleration of healing of diabetic wounds

By constructing nanocomposite hydrogels of oxidized hyaluronic acid, phenylboric acid grafted ε-polylysine and ZIF-8, the problem of insufficient adhesion and mechanical properties of traditional hydrogels in diabetic wounds is solved, and effective response and antioxidant stress in a low pH and high ROS environment is achieved, and wound healing is promoted.

CN120346364APending Publication Date: 2025-07-22INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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Patent Information

Application Number
CN202410056950.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-01-15
Publication Date
2025-07-22

AI Technical Summary

Technical Problem

Traditional hydrogels lack tissue adhesion, poor mechanical properties and lack self-healing ability in biomedical applications, and frequent dressing replacement may lead to wound irritation and infection risks. The existing stimulus-responsive hydrogels have limited effect at diabetic wounds.

Method used

A nanocomposite hydrogel is developed, consisting of oxidized hyaluronic acid, phenylboronic acid-grafted ε-polylysine and ZIF-8. It responds to a low pH and high ROS environment through dynamic Schiff base, borate ester bonds and coordination bonds, releases zinc ions and chlorogenic acid, regulates macrophage phenotype, relieves oxidative stress, promotes cell proliferation and angiogenesis.

Benefits of technology

The injectable, adhesion, self-healing and excellent mechanical properties of the hydrogel are achieved, which can effectively respond to and relieve oxidative stress at diabetic wounds, accelerate wound healing, regulate macrophage phenotype through the NF-κB/JAK-STAT signaling pathway, and promote tissue repair.

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses a preparation method of nano composite hydrogel and application of the nano composite hydrogel in acceleration of healing of diabetic wounds. The invention constructs the hydrogel based on the epsilon-polylysine grafted by the oxidized hyaluronic acid and the phenylboronic acid and the ZIF-8. Due to the existence of the dynamic Schiff base, the boric acid ester bond and the coordination bond, the hydrogel has ideal mechanical property, strong viscosity, injectability, self-healing property and pH / ROS responsiveness. Due to the existence of chlorogenic acid and zinc ions, the hydrogel regulates macrophage phenotypes, relieves oxidative stress and accelerates healing of diabetic wounds through an NF-kappa B / JAK-STAT signal channel.
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