Polysaccharide nano-carrier production device

Abstract

The invention belongs to the field of biological materials and nanotechnology, and discloses a polysaccharide nano-carrier production device, which comprises a box body, which is designed to be rectangular and is internally provided with a rectangular groove I and a rectangular groove II from top to bottom in sequence; the grinding barrel is installed in the first rectangular groove in a threaded mode, a grinding groove is formed in the grinding barrel, and the section of the grinding groove is in the shape of two cones, so that the middle is thin and the two ends are thick; and the funnel is fixedly installed at the bottom of the first rectangular groove and extends into the second rectangular groove, and a discharging channel is fixedly installed at the bottom of the funnel. By arranging the grinding mechanism, the rotating column and the connecting rod are used for driving the grinding cone to conduct efficient grinding, and through rotation of the grinding cone, the contact area of materials is increased; the grinding efficiency is improved through the eccentric design, the height of the grinding barrel can be adjusted according to the properties of materials by combining the inclined design in the grinding barrel, the grinding effect can be accurately controlled, and the generation of nanoscale polysaccharide particles is ensured, so that the consistency and the quality of products are improved.

Description

Technical Field

[0001] The present invention belongs to the fields of biomaterials and nanotechnology, and specifically relates to a production device for polysaccharide nanocarriers. Background Art

[0002] The technical background of the production device for polysaccharide nanocarriers involves multiple interdisciplinary fields such as materials science, nanotechnology, and biomedical engineering. Polysaccharides are a class of high-molecular compounds formed by the connection of various monosaccharides through glycosidic bonds, widely existing in nature and having various unique physical and chemical properties. Common natural polysaccharides include chitosan, alginate, hyaluronic acid, dextran, etc. The core lies in utilizing the biocompatibility, biodegradability, and low toxicity of natural polysaccharides to develop efficient drug delivery systems.

[0003] For example, the utility model with the publication number CN211329791U discloses a crushing and screening device for the preparation of edible mushroom composite polysaccharides, including a first frame. Horizontal frames are respectively arranged on both sides of the first frame, and a number of card slots are arranged on the horizontal frames. A first screening box is arranged on one side inside the first frame. In the present utility model, through the setting of multiple screening boxes for the traditional vibrating screen, and the integration of crushing and screening, through the vertical position setting of the screening boxes, the materials that meet the requirements of the current screening box will enter the next screening box during vibration screening, and those that do not meet the requirements will enter another screening box for pre-screening before the finished product. Multi-stage screening can make the screened materials meet the requirements of the finished product. In addition, the screening boxes are in a closed environment, especially for the materials used in the preparation of edible mushroom composite polysaccharides, which provides a good screening environment and prevents the influence of external environmental pollutants during the screening process, thus controlling the quality.

[0004] The above device performs multi-stage screening by setting multiple screening boxes. Therefore, the different screening grades are determined according to the number of screening boxes. First, it increases the complexity of the equipment, making the maintenance, repair, and cleaning work of the equipment more cumbersome and time-consuming. Each screening box needs to be regularly inspected, cleaned, and maintained. Especially when dealing with viscous materials or materials with high corrosiveness, the workload of cleaning and maintenance will increase significantly, thus affecting the production efficiency. Moreover, each screening box needs to be equipped with an independent screen, transmission device, and discharge port, resulting in a complex overall equipment structure and an increase in the number of fault points. If the vibration motor of one of the screening boxes is damaged, it may affect the continuity of the entire screening process.

[0005] Therefore, a production device for polysaccharide nanocarriers is proposed to solve the problems raised in the background art. Summary of the Invention

[0006] To solve the problems raised in the above background art, the present invention provides a production device for polysaccharide nanocarriers.

[0007] To achieve the above object, the present invention provides the following technical solutions: a polysaccharide nanocarrier production device, including;

[0008] A box body, designed in a rectangle, with a rectangular groove 1 and a rectangular groove 2 successively opened from top to bottom inside it;

[0009] A grinding barrel, threadedly installed inside the rectangular groove 1, with a grinding groove opened inside the grinding barrel, and the cross-section of the grinding groove is composed of two cones, being thin in the middle and thick at both ends;

[0010] A funnel, fixedly installed at the bottom of the rectangular groove 1 and extending into the rectangular groove 2, with a blanking channel fixedly installed at the bottom of the funnel, and a one-way valve arranged at the top of the blanking channel;

[0011] A rotating rod 3, rotatably installed on the inner wall of the rectangular groove 2 and with one end extending outside the box body;

[0012] A collection box, rotatably installed on the outer wall of the rotating rod 3 and fixedly connected to the box body, and the collection box is communicated with the blanking channel;

[0013] A threaded rod, rotatably installed on the inner wall of the rectangular groove 2 and perpendicularly designed and installed with the rotating rod 3, and one end of the rotating rod 3 extends outside the box body;

[0014] A motor, fixedly installed on the outer wall of the box body;

[0015] A grinding mechanism, arranged inside the grinding barrel;

[0016] An adjusting mechanism, threadedly installed on the outer wall of the threaded rod;

[0017] A screening mechanism, arranged inside the collection box.

[0018] Preferably, the grinding mechanism includes a power component and an adjusting component. The power component includes a grinding cone rotatably installed inside the grinding barrel. A connecting rod is fixedly installed at the bottom of the grinding cone. A rotating column is fixedly sleeved on the outer wall of the connecting rod. An installation block is rotatably sleeved on the outer wall of the rotating column, and the installation block is fixedly connected to the inner wall of the funnel.

[0019] Preferably, a bevel gear 1 is fixedly sleeved on the top outer wall of the rotating column. A rotating rod 2 is rotatably installed on the inner wall of the rectangular groove 2. A bevel gear 2 is fixedly sleeved on the outer wall of the rotating rod 2 near the bevel gear 1. The bevel gear 2 meshes with the bevel gear 1. The other end of the rotating rod 2 extends outside the box body and is fixedly connected to the output shaft of the motor.

[0020] Preferably, the adjusting assembly includes a plurality of teeth fixedly installed on the outer wall of the grinding barrel. The plurality of teeth are evenly distributed in a circular pattern at equal distances around the axis of the grinding barrel on the outer wall of the grinding barrel and are all located inside the first rectangular groove.

[0021] Preferably, a first rotating rod is rotatably installed inside the first rectangular groove. A tooth column is fixedly sleeved on the outer wall of the first rotating rod. The tooth column meshes with the teeth, and the height value of the tooth column is greater than the height value of the teeth.

[0022] Preferably, the adjusting mechanism includes a moving block threadedly sleeved on the outer wall of the threaded rod. A fourth rotating rod is rotatably installed on one side of the moving block.

[0023] Preferably, chain wheels are fixedly sleeved on the outer walls of the moving block, the second rotating rod, and the third rotating rod, and they are all connected by a chain drive.

[0024] Preferably, a limiting slide rod is fixedly installed on the inner wall of the second rectangular groove. The limiting slide rod penetrates through the moving block and is slidably connected to the moving block.

[0025] Preferably, the screening mechanism includes a screening barrel rotatably installed on the outer wall of the third rotating rod. An auger is fixedly installed on the outer wall of the third rotating rod. The auger is located inside the screening barrel. A discharge pipe is fixedly installed on one side of the screening barrel, and the discharge pipe is communicated with the screening barrel.

[0026] Preferably, a plurality of groups of screening grooves are formed at the bottom of the screening barrel. The opening sizes of the three groups of screening grooves are different, and the opening sizes of the screening grooves gradually increase from the side close to the third rotating rod to the discharge pipe.

[0027] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0028] By setting the grinding mechanism, the present invention uses the rotating column and the connecting rod to drive the grinding cone for efficient grinding. The rotation of the grinding cone not only increases the contact area of the material but also improves the grinding efficiency through the eccentric design. Combined with the inclined design inside the grinding barrel, and the height of the grinding barrel can be adjusted according to the properties of the material to precisely control the grinding effect, ensuring the generation of nanoscale polysaccharide particles, thereby improving the consistency and quality of the product.

[0029] By setting the adjusting mechanism, through the cooperation of the threaded rod and the moving block, the present invention provides a flexible function for adjusting the grinding effect. Operators can, according to actual needs, adjust the tension of the threaded rod and the chain, improving the adaptability of the equipment, enabling it to meet different production requirements and ensuring the stability and high efficiency of production.

[0030] The present invention effectively classifies the ground materials by setting a screening mechanism and designing screening grooves of different sizes. The configuration of the auger ensures that the materials can pass through the screening grooves evenly, avoiding blockage problems and improving the screening efficiency. According to the different sizes of the material particles, the qualified particles are gradually screened out through the screening grooves, ensuring the quality and consistency of the final product, preventing large-particle materials from entering the final collection box, and enhancing the accuracy and efficiency of the production process. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 is a schematic diagram of the overall structure of the present invention;

[0032] Figure 2 is a schematic diagram of a partial cross-sectional structure of the box body of the present invention;

[0033] Figure 3 is a schematic diagram of the internal structure of the box body of the present invention;

[0034] Figure 4 is a schematic diagram of the structure of the screening groove of the present invention;

[0035] Figure 5 is a schematic diagram of the mating structure of the adjusting mechanism of the present invention;

[0036] Figure 6 is a schematic diagram of the front cross-sectional structure of the grinding mechanism of the present invention;

[0037] Figure 7 is a schematic diagram of the structure of the adjusting component of the present invention;

[0038] Figure 8 is a schematic diagram of the exploded structure of the grinding mechanism of the present invention.

[0039] In the figure: 1. Box body; 11. First rectangular groove; 111. First rotating rod; 1111. Tooth column; 12. Second rectangular groove; 2. Grinding barrel; 21. Teeth; 22. Grinding groove; 3. Hopper; 31. Mounting block; 311. Rotating column; 3111. First bevel gear; 312. Connecting rod; 3121. Grinding cone; 32. Feeding channel; 4. Second rotating rod; 41. Second bevel gear; 5. Third rotating rod; 51. Auger; 52. Screening barrel; 521. Screening groove; 53. Discharge pipe; 54. Collection box; 6. Threaded rod; 61. Moving block; 611. Fourth rotating rod; 62. Limit slide bar; 7. Chain; 8. Motor. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0040] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0041] As Figures 1 to 8 shown, the present invention provides a polysaccharide nanocarrier production device, including;

[0042] A box body 1, which is rectangularly designed and is internally provided with a rectangular groove 11 and a rectangular groove 12 from top to bottom in sequence;

[0043] A grinding barrel 2, which is threadedly installed inside the rectangular groove 11. A grinding groove 22 is provided inside the grinding barrel 2, and the cross-section of the grinding groove 22 is composed of two cones and is thinner in the middle and thicker at both ends;

[0044] A funnel 3, which is fixedly installed at the bottom of the rectangular groove 11 and extends into the rectangular groove 12. A blanking channel 32 is fixedly installed at the bottom of the funnel 3, and a one-way valve is arranged at the top of the blanking channel 32;

[0045] A rotating rod 5, which is rotatably installed on the inner wall of the rectangular groove 12 and one end extends outside the box body 1;

[0046] A collection box 54, which is rotatably installed on the outer wall of the rotating rod 5 and is fixedly connected to the box body 1. The collection box 54 is communicated with the blanking channel 32;

[0047] A threaded rod 6, which is rotatably installed on the inner wall of the rectangular groove 12 and is perpendicularly designed and installed with the rotating rod 5. One end of the rotating rod 5 extends outside the box body 1;

[0048] A motor 8, which is fixedly installed on the outer wall of the box body 1;

[0049] A grinding mechanism, which is arranged inside the grinding barrel 2;

[0050] An adjusting mechanism, which is threadedly installed on the outer wall of the threaded rod 6;

[0051] The screening mechanism is arranged inside the collection box 54; the grinding mechanism includes a power component and an adjustment component. The power component includes a grinding cone 3121 rotatably installed inside the grinding barrel 2. A connecting rod 312 is fixedly installed at the bottom of the grinding cone 3121. A rotating column 311 is fixedly sleeved on the outer wall of the connecting rod 312. An installation block 31 is rotatably sleeved on the outer wall of the rotating column 311. The installation block 31 is fixedly connected to the inner wall of the funnel 3; a first bevel gear 3111 is fixedly sleeved on the top outer wall of the rotating column 311. A second rotating rod 4 is rotatably installed on the inner wall of the second rectangular groove 12. A second bevel gear 41 is fixedly sleeved on the outer wall of the end of the second rotating rod 4 close to the first bevel gear 3111. The second bevel gear 41 meshes with the first bevel gear 3111. The other end of the second rotating rod 4 extends outside the box body 1 and is fixedly connected to the output shaft of the motor 8; the adjustment component includes a plurality of teeth 21 fixedly installed on the outer wall of the grinding barrel 2. The plurality of teeth 21 are circumferentially distributed at equal distances around the axis of the grinding barrel 2 on the outer wall of the grinding barrel 2 and are all located inside the first rectangular groove 11; a first rotating rod 111 is rotatably installed inside the first rectangular groove 11. A tooth column 1111 is fixedly sleeved on the outer wall of the first rotating rod 111. The tooth column 1111 meshes with the teeth 21. The height value of the tooth column 1111 is greater than the height value of the teeth 21.

[0052] Adopting the above scheme: The box body 1 is designed as a rectangular structure, in which a first rectangular groove 11 and a second rectangular groove 12 are successively provided, optimizing the utilization of space. Inside the first rectangular groove 11, the grinding barrel 2 is installed by means of threads, enabling its stable rotation and vertical movement; the funnel 3 is installed at the bottom of the first rectangular groove 11 and extends into the second rectangular groove 12. The design of the funnel 3 enables the ground material to smoothly transition to the feeding channel 32. The feeding channel 32 is equipped with a one-way valve, ensuring the one-way flow of the material, preventing the problems of backflow and blockage, and improving the stability and continuity of the production process; at the same time, the connection between the funnel 3 and the collection box 54 enables the ground material to be efficiently collected and stored, ensuring the efficiency and convenience of the production process. The rotational design of the third rotating rod 5 and the gear transmission cooperation with the second rotating rod 4 can effectively achieve the transmission of mechanical power and drive the operation of the entire system; the screening mechanism inside the collection box 54 can sort the ground and processed materials, ensuring the quality and consistency of the final product; the screening mechanism can screen out large particle substances, ensuring that the materials entering the final collection container are all fine particles meeting the requirements; through the adjustment function of the threaded rod 6, the grinding effect during the entire grinding process can be adjusted as needed; by adjusting the threaded rod 6, the contact degree between the material inside the grinding barrel 2 and the grinding cone 3121 can be finely controlled, thereby optimizing the production effect of the nano carrier; the motor 8 provides power support for the device, rotating and driving the second rotating rod 4 and the third rotating rod 5, and realizing the grinding operation under the transmission cooperation between the first bevel gear 3111 and the second bevel gear 41.

[0053] like Figures 3 to 4 As shown, the adjustment mechanism includes a moving block 61 threadedly sleeved on the outer wall of the litigation threaded rod 6, and a rotating rod four 611 is rotatably installed on one side of the moving block 61; chain wheels are fixedly sleeved on the outer walls of the moving block 61, the rotating rod two 4 and the rotating rod three 5, and are all connected by a chain 7 transmission; a limiting slide bar 62 is fixedly installed on the inner wall of the rectangular groove two 12, and the limiting slide bar 62 passes through the moving block 61 and is slidably connected to the moving block 61.

[0054] The above scheme is adopted: through the existence of the moving block 61 and its rotational connection with the rotating rod four 611, the adjustment mechanism can provide a flexible adjustment range in actual operation; the rotating rod four 611 drives the moving block 61 to move axially along the threaded rod 6, thereby adjusting the contact strength between the grinding barrel 2 and the grinding cone 3121; the grinding process is more controllable, and the grinding accuracy can be adjusted in real time according to different material properties and production requirements, thereby improving the yield and consistency of the nanocarrier; the chain wheels fixed on the outer walls of the moving block 61, the rotating rod two 4 and the rotating rod three 5 are connected through the chain 7 transmission, The synchronous and coordinated work of multiple transmission components is realized, and the transmission mode of the chain 7 enables it to move in parallel at the same time, ensuring the movement accuracy and synchronization of each part, avoiding the deviation caused by the inconsistent movement of different parts, and ensuring the consistency and stability of the production process; through the fixed installation of the limit slide 62, not only a stable track is provided for the sliding of the moving block 61, avoiding the excessive movement or deviation of the moving block 61 from the normal track, but also plays an effective limiting role; through the guiding role of the limit slide 62, it is ensured that the moving block 61 is within the predetermined range during the entire adjustment process.

[0055] like Figures 4 to 5 As shown, the screening mechanism includes a screening barrel 52 rotatably mounted on the outer wall of the rotating rod three 5, an auger 51 is fixedly mounted on the outer wall of the rotating rod three 5, the auger 51 is located inside the screening barrel 52, a discharge pipe 53 is fixedly mounted on one side of the screening barrel 52, and the discharge pipe 53 is connected to the screening barrel 52; a plurality of groups of screening slots 521 are provided at the bottom of the screening barrel 52, and the opening sizes of the three groups of screening slots 521 are different, and the opening sizes of the screening slots 521 increase successively from the side close to the rotating rod three 5 to the discharge pipe 53.

[0056] Adopting the above solution: The screening of materials is realized by rotating the screening barrel 52 installed on the outer wall of the third rotating rod 5; a auger 51 is arranged inside the screening barrel 52, and the auger 51 pushes the materials to flow forward and performs grading screening through the screening slots 521; during the screening process, according to the different particle sizes of the materials, the materials are divided into different particle levels through the screening slots 521 of different sizes, achieving the effects of sorting and removing impurities; the auger 51 effectively drives the materials to move forward through its spiral structure, avoiding the problem of uneven screening caused by the deposition or accumulation of materials in the screening barrel 52; the configuration of the auger 51 enables the materials to evenly pass through the screening slots 521, and during the material conveying process, the auger 51 can effectively break up the possible agglomerated materials to ensure the smoothness of the materials passing through the screening slots 521; according to the different opening sizes of the screening slots 521, designed to gradually increase from the side close to the third rotating rod 5 to the side of the discharge pipe 53, the materials can be gradually screened in the order of increasing particle size from small to large; this not only helps to improve the screening accuracy but also avoids large particle materials getting stuck in the screening slots 521, resulting in blockage or reduced efficiency during the screening process; due to the gradually sized design of the screening slots 521, after the materials pass through the screening slots 521 with different screen sizes, materials of different particle sizes can be separated, effectively realizing the classification treatment of particles; the discharge pipe 53 is connected to the screening barrel 52 and is used to discharge the screened materials from the screening barrel 52; through the setting of the discharge pipe 53, the different screened materials can flow out quickly and smoothly, avoiding the retention or accumulation of materials during the screening process, thereby improving the screening efficiency; the reasonable design of the position and angle of the discharge pipe 53 also helps to ensure the smooth discharge of materials, reduce blockage phenomena, optimize the production process, and the efficient operation of the screening mechanism can ensure the consistency and stability of the particle size of the materials in the same batch of production, thus ensuring the quality consistency of the final product.

[0057] The working principle and usage process of the present invention:

[0058] First, adjust the grinding mechanism according to the required particle size. The operator rotates the first rotating rod 111 to drive the tooth column 1111 to rotate. Through the meshing of the tooth column 1111 and the tooth teeth 21, the tooth teeth 21 are driven to rotate. Due to the threaded connection between the grinding barrel 2 and the box body 1, the grinding barrel 2 can move vertically along the axis of the box body 1. Since the inner wall of the grinding barrel 2 is inclined, by changing the vertical height of the grinding barrel 2, the contact distance between the grinding barrel 2 and the grinding cone 3121 is changed, thereby changing the size of the ground polysaccharide particles:

[0059] Then, adjust the tension and alignment of the chain 7. The operator can rotate the threaded rod 6. Through the threaded connection between the threaded rod 6 and the moving block 61, the moving block 61 can convert the rotation of the threaded rod 6 into a force for horizontal movement along the axis of the threaded rod 6. By changing the horizontal position of the threaded rod 6, the slack of the chain 7 is absorbed, so that the chain 7 wound around the outer walls of the second rotating rod 4, the third rotating rod 5, and the fourth rotating rod 611 maintains a constant tension.

[0060] Then, put the polysaccharide raw material to be ground into the grinding barrel 2, start the motor 8, drive the second rotating rod 4 to rotate through the output shaft of the motor 8, and drive the third rotating rod 5 and the fourth rotating rod 611 to rotate together through the transmission of the chain 7.

[0061] Drive the second bevel gear 41 to rotate through the second rotating rod 4. Through the meshing of the second bevel gear 41 and the first bevel gear 3111, drive the first bevel gear 3111 to rotate. Drive the rotating column 311 and the connecting rod 312 to rotate through the first bevel gear 3111. Drive the grinding cone 3121 to rotate through the connecting rod 312. Due to the eccentric design of the rotating column 311 and the connecting rod 312, the inner wall of the grinding barrel 2 and the grinding cone 3121 grind the polysaccharide raw material during rotation. After grinding, open the valve at the top of the blanking channel 32, so that the raw material enters the screening barrel 52 through the funnel 3 and the blanking channel 32. Drive the auger 51 to rotate through the rotation of the third rotating rod 5. Through the rotation of the auger 51, move the raw material located in the screening barrel 52 towards the discharge pipe 53. Since different-sized screening slots 521 are provided at the bottom of the screening barrel 52, the raw material can fall into the collection box 54 through the screening slots 521 during the movement of the raw material. If the ground raw material particles are too large, they will enter the discharge pipe 53 for collection and then be put into the grinding barrel 2 for secondary grinding.

[0062] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device.

[0063] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A polysaccharide nanocarrier production device, characterized in that, including; a box body (1), which is rectangular in design and is internally provided with a rectangular groove one (11) and a rectangular groove two (12) in sequence from top to bottom; a grinding barrel (2), which is threadedly installed inside the rectangular groove one (11), and a grinding groove (22) is provided inside the grinding barrel (2), and the cross-section of the grinding groove (22) is composed of two cones and is thin in the middle and thick at both ends; a funnel (3), which is fixedly installed at the bottom of the rectangular groove one (11) and extends into the rectangular groove two (12), and a blanking channel (32) is fixedly installed at the bottom of the funnel (3), and a one-way valve is arranged at the top of the blanking channel (32); a third rotating rod (5), which is rotatably installed on the inner wall of the rectangular groove two (12) and one end extends outside the box body (1); a collection box (54), which is rotatably installed on the outer wall of the third rotating rod (5) and is fixedly connected to the box body (1), and the collection box (54) is communicated with the blanking channel (32); a threaded rod (6), which is rotatably installed on the inner wall of the rectangular groove two (12) and is perpendicularly designed and installed with the third rotating rod (5), and one end of the third rotating rod (5) extends outside the box body (1); a motor (8), which is fixedly installed on the outer wall of the box body (1); a grinding mechanism, which is arranged inside the grinding barrel (2); an adjusting mechanism, which is threadedly installed on the outer wall of the threaded rod (6); a screening mechanism, which is arranged inside the collection box (54).

2. The polysaccharide nanocarrier production device according to claim 1, characterized in that: The grinding mechanism includes a power component and an adjusting component. The power component includes a grinding cone (3121) rotatably installed inside the grinding barrel (2). A connecting rod (312) is fixedly installed at the bottom of the grinding cone (3121). A rotating column (311) is fixedly sleeved on the outer wall of the connecting rod (312). An installation block (31) is rotatably sleeved on the outer wall of the rotating column (311), and the installation block (31) is fixedly connected to the inner wall of the funnel (3).

3. The polysaccharide nanocarrier production device according to claim 2, wherein: A first bevel gear (3111) is fixedly sleeved on the top outer wall of the rotating column (311). A second rotating rod (4) is rotatably installed on the inner wall of the rectangular groove two (12). A second bevel gear (41) is fixedly sleeved on the outer wall of one end of the second rotating rod (4) close to the first bevel gear (3111). The second bevel gear (41) meshes with the first bevel gear (3111). The other end of the second rotating rod (4) extends outside the box body (1) and is fixedly connected to the output shaft of the motor (8).

4. The polysaccharide nanocarrier production device according to claim 1, characterized in that: The adjusting component includes a plurality of teeth (21) fixedly installed on the outer wall of the grinding barrel (2). The plurality of teeth (21) are circumferentially distributed at equal distances around the axis of the grinding barrel (2) on the outer wall of the grinding barrel (2) and are all located inside the rectangular groove one (11).

5. The polysaccharide nanocarrier production device according to claim 4, wherein: A first rotating rod (111) is rotatably installed inside the rectangular groove one (11). A tooth column (1111) is fixedly sleeved on the outer wall of the first rotating rod (111). The tooth column (1111) meshes with the teeth (21), and the height value of the tooth column (1111) is greater than the height value of the teeth (21).

6. The polysaccharide nanocarrier production device according to claim 1, characterized in that: The adjustment mechanism comprises a moving block (61) threadedly sleeved on the outer wall of the litigation threaded rod (6), and a rotating rod four (611) is rotatably mounted on one side of the moving block (61).

7. The polysaccharide nanocarrier production device according to claim 6, wherein: Chain wheels are fixedly sleeved on the outer walls of the moving block (61), the second rotating rod (4) and the third rotating rod (5), and are all connected by a chain (7).

8. The polysaccharide nanocarrier production device according to claim 6, characterized in that: A limiting slide bar (62) is fixedly mounted on the inner wall of the second rectangular groove (12), and the limiting slide bar (62) passes through the moving block (61) and is slidably connected to the moving block (61).

9. The polysaccharide nanocarrier production device according to claim 1, characterized in that: The screening mechanism comprises a screening barrel (52) rotatably mounted on the outer wall of the rotating rod three (5); an auger (51) is fixedly mounted on the outer wall of the rotating rod three (5); the auger (51) is located inside the screening barrel (52); a discharge pipe (53) is fixedly mounted on one side of the screening barrel (52); the discharge pipe (53) is communicated with the screening barrel (52).

10. The polysaccharide nanocarrier production device according to claim 9, characterized in that; The bottom of the screening barrel (52) is provided with a plurality of groups of screening slots (521), and the opening sizes of the three groups of screening slots (521) are different, and the opening sizes of the screening slots (521) increase from the side close to the rotating rod three (5) to the discharge pipe (53).

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