Traditional Chinese medicine decoction for improving skin sore and ulcer and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine decoction for improving skin sores and ulcers and a preparation method thereof, and provides a traditional Chinese medicine decoction for treating skin sores and ulcers, aiming at the defects that the cost is high and the traditional Chinese medicine decoction is limited by the age of a patient and the basic illness state in the current treatment of skin sores and ulcers, the traditional Chinese medicine decoction for treating skin sores and ulcers comprises the following components by mass: 15-30g of astragalus membranaceus, 5-10g of red paeony root and 5-10g of divaricate saposhnikovia root. Wherein the radix astragali has the effects of tonifying qi and deficiency, and moving the exterior to strengthen the health; the radix paeoniae rubra has the effects of cooling blood, activating blood, dispersing blood stasis and relieving pain; radix saposhnikoviae can dispel wind and strengthen qi; through compatibility of the three medicines, the qi tonifying and blood circulation promoting effects of the astragalus membranaceus are enhanced, qi is sufficient, blood is activated, stagnation can be removed, wind is dispelled, collaterals are dredged, qi movement of the whole body can be smooth, blood circulation is promoted, and blood stasis is removed, so that the skin state is improved. In addition, compared with a traditional decoction, the decoction has the advantages that the formula is simpler, the cost is lower, the three medicines are compatible, the qi tonifying and blood circulation promoting effects of the astragalus membranaceus are enhanced, qi is sufficient, blood is activated, stagnation can be removed, wind can be dispelled, collaterals can be dredged, qi movement of the whole body can be smooth, and blood circulation can be promoted to remove blood stasis. The method for treating skin ulcers is effective and economical, materials are easy to obtain, the patient acceptability is high, and the compliance is good.

Description

Technical Field

[0001] The present disclosure relates to the field of biomedical technologies, and particularly to a traditional Chinese medicine decoction for improving skin sores and its preparation method. Background Art

[0002] Some patients with skin sores are restricted from undergoing surgical treatment due to age and underlying diseases, or the cost of surgical treatment is high, and the therapeutic effects of western medicine such as drugs for nourishing nerves and dilating blood vessels are limited. Skin ulcers and bleeding caused by skin sores in patients can lead to skin necrosis, local infection, or aggravation of infection resulting in systemic infection, etc. The traditional Chinese medicine syndrome differentiation of skin sores may be wind-heat type, damp-heat type, qi stagnation and blood stasis type, blood stasis blocking collaterals type, spleen deficiency and dampness entrapment type, etc. The current western medicine clinical treatment mainly solves local problems and cannot address the fundamental factors of the patient's constitution, making it easy for local wounds not to heal or recur.

[0003] Currently, surgical treatment faces economic and psychological difficulties such as repeated dressing changes after surgery and patient pain. In addition, some drugs for local use in traditional Chinese medicine, such as frankincense and myrrh, deviate from the concept of asepsis in clinical evidence-based medicine and are difficult to use in actual medical activities.

[0004] Therefore, it is necessary to propose a herbal medicine for further improving skin sores in patients to solve the above problems. Summary of the Invention

[0005] On the one hand, the present application proposes a traditional Chinese medicine decoction for improving skin sores, and the traditional Chinese medicine decoction includes the following components in mass ratio: 15 - 30 g of astragalus membranaceus, 5 - 10 g of radix paeoniae rubra, and 5 - 10 g of ledebouriella seseloides.

[0006] A preparation method of a traditional Chinese medicine decoction for improving skin sores includes the following steps:

[0007] Weigh 15 - 30 g of astragalus membranaceus, 5 - 10 g of radix paeoniae rubra, and 5 - 10 g of ledebouriella seseloides according to the amount;

[0008] Put the weighed 15 - 30 g of astragalus membranaceus, 5 - 10 g of radix paeoniae rubra, and / or 5 - 10 g of ledebouriella seseloides into a decocting device and soak in water for 30 min - 1 h;

[0009] After soaking, bring to a boil over high heat and then turn to low heat and decoct for 10 - 20 min;

[0010] Obtain the traditional Chinese medicine decoction.

[0011] On the other hand, the present application proposes a traditional Chinese medicine decoction for improving skin sores, and the traditional Chinese medicine decoction includes the following components in mass ratio: 30 g of astragalus membranaceus, 5 g of radix paeoniae rubra, and 5 g of ledebouriella seseloides. The preparation method of this traditional Chinese medicine decoction includes the following steps:

[0012] Weigh 30 g of Astragalus membranaceus, 5 g of Paeonia lactiflora Pall., and 5 g of Saposhnikovia divaricata Turcz. according to the amount;

[0013] First, put the weighed Astragalus membranaceus into the decocting equipment and soak it in water alone for 1 h, then put Paeonia lactiflora Pall. and Saposhnikovia divaricata Turcz. into it and soak for 30 min;

[0014] After soaking, bring to a boil over high heat, then turn to low heat and decoct for 10 min;

[0015] Obtain the traditional Chinese medicine decoction;

[0016] Among them, the active ingredients in the traditional Chinese medicine decoction are as follows:

[0017] Astragaloside Ⅳ ≥ 0.85 mg / g;

[0018] Paeoniflorin ≥ 0.9 mg / g;

[0019] Prim-O-glucosylcimifugin ≥ 0.07 mg / g.

[0020] On the other hand, this application also proposes a traditional Chinese medicine decoction for improving skin sores. The traditional Chinese medicine decoction includes the following components in mass ratio: 15 g of Astragalus membranaceus, 10 g of Paeonia lactiflora Pall., and 10 g of Saposhnikovia divaricata Turcz. The preparation method of this traditional Chinese medicine decoction includes the following steps:

[0021] Weigh 15 g of Astragalus membranaceus, 10 g of Paeonia lactiflora Pall., and 10 g of Saposhnikovia divaricata Turcz. according to the amount;

[0022] First, process Paeonia lactiflora Pall. by vinegar frying, then put it together with Astragalus membranaceus and Saposhnikovia divaricata Turcz. into the decocting equipment and soak in water for 50 min;

[0023] After soaking, bring to a boil over high heat for 5 min, then turn to low heat and decoct for 15 min;

[0024] Obtain the traditional Chinese medicine decoction;

[0025] Among them, the active ingredients in the traditional Chinese medicine decoction are as follows:

[0026] Paeoniflorin ≥ 1.8 mg / g;

[0027] Astragaloside Ⅳ ≥ 0.48 mg / g;

[0028] Saposhnikovia divaricata Turcz. polysaccharide ≥ 12 mg / g.

[0029] On the other hand, this application also proposes a traditional Chinese medicine decoction for improving skin sores. The traditional Chinese medicine decoction includes the following components in mass ratio: 25 g of Astragalus membranaceus, 6 g of Paeonia lactiflora Pall., and 10 g of Saposhnikovia divaricata Turcz. The preparation method of this traditional Chinese medicine decoction includes the following steps:

[0030] Weigh 25 g of Astragalus membranaceus, 6 g of Paeonia lactiflora Pall., and 10 g of Saposhnikovia divaricata Turcz. according to the amount;

[0031] First, superfine pulverize Saposhnikovia divaricata Turcz. (particle size ≤ 50 μm) and then decoct it alone for 8 min;

[0032] Astragalus membranaceus and Paeonia lactiflora Pall. are put into a decocting device and soaked in water for 30 minutes;

[0033] After soaking, add the medicinal liquid of Saposhnikovia divaricata (Turcz.) Schischk. that has been decocted separately, and bring to a boil over high heat for 3 minutes;

[0034] Obtain a traditional Chinese medicine decoction;

[0035] Among them, the active ingredients in the traditional Chinese medicine decoction are as follows:

[0036] Hesperidin ≥ 0.15 mg / g;

[0037] Calycosin ≥ 0.3 mg / g;

[0038] Total flavonoids ≥ 4.2 mg / g.

[0039] On the other hand, this application also proposes an application of the above-mentioned traditional Chinese medicine decoction in improving skin sores.

[0040] Technical effects of the present invention:

[0041] Aiming at the disadvantages of high cost and being restricted by the age and underlying diseases of patients in the current treatment of skin sores, this application provides a traditional Chinese medicine decoction for treating skin sores. The mass ratio of its formula is: 15 - 30 g of Astragalus membranaceus, 5 - 10 g of Paeonia lactiflora Pall., and 5 - 10 g of Saposhnikovia divaricata (Turcz.) Schischk. Among them, Astragalus membranaceus benefits qi and tonifies deficiency, moves to the exterior and strengthens the defense; Paeonia lactiflora Pall. exerts its effects of cooling blood, promoting blood circulation, and dispelling stasis and relieving pain; Saposhnikovia divaricata (Turcz.) Schischk. can dispel wind and strengthen qi; the combination of the three herbs strengthens the effect of Astragalus membranaceus in promoting qi and activating blood circulation, making qi sufficient and blood active, capable of promoting qi movement, dispelling wind, and dredging collaterals, and can make the qi mechanism of the whole body smooth, promoting blood circulation and removing blood stasis, thereby improving the skin condition.

[0042] In addition, compared with traditional decoctions, this decoction has a simpler formula, lower cost, and can further improve the skin sores of patients, with good clinical effects. The combination of the three herbs strengthens the effect of Astragalus membranaceus in promoting qi and activating blood circulation, making qi sufficient and blood active, capable of promoting qi movement, dispelling wind, and dredging collaterals, and can make the qi mechanism of the whole body smooth and promote blood circulation and remove blood stasis. This method for treating skin sores is effective, economical, and easy to obtain materials, with high acceptance and good compliance among patients.

[0043] According to the following detailed description of exemplary embodiments with reference to the accompanying drawings, other features and aspects of the present disclosure will become clear. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] The accompanying drawings, which are included in and constitute a part of this specification, illustrate the exemplary embodiments, features, and aspects of the present disclosure together with the specification, and are used to explain the principles of the present disclosure.

[0045] Figure 1 Shows the comparative effect diagrams before and after the treatment of skin sores on the left leg of a patient. Detailed implementation mode

[0046] The special term "exemplary" here means "serving as an example, embodiment or illustration". Any embodiment described as "exemplary" here does not have to be construed as superior to or better than other embodiments.

[0047] In addition, in order to better illustrate the present disclosure, numerous specific details are given in the following detailed implementation mode. Those skilled in the art should understand that the present disclosure can also be implemented without certain specific details. In some instances, means, elements and circuits well known to those skilled in the art are not described in detail so as to highlight the gist of the present disclosure.

[0048] The equipment, conditions for decocting traditional Chinese medicine, etc. in this embodiment can be provided by the hospital. And the corresponding technical terms, etc. can refer to industry explanations or traditional Chinese medicine experience.

[0049] A traditional Chinese medicine decoction for improving skin sores. Aiming at the disadvantages of high cost and being restricted by the age and basic condition of patients in the current treatment of skin sores, a traditional Chinese medicine decoction for treating skin sores is provided. The mass ratio of its formula is: 15 - 30 g of Astragalus membranaceus, 5 - 10 g of Red Peony Root, and 5 - 10 g of Ledebouriella seseloides. Among them, Astragalus membranaceus benefits qi and tonifies deficiency, walks on the surface and strengthens the defense; Red Peony Root exerts its effects of cooling blood, promoting blood circulation, dissipating stasis and relieving pain; Ledebouriella seseloides can dispel wind and strengthen qi; the combination of the three herbs strengthens the effect of Astragalus membranaceus in promoting qi and activating blood circulation, making qi sufficient and blood active, capable of promoting qi movement, dispelling wind and dredging collaterals, and can make the qi mechanism of the whole body smooth, promoting blood circulation to remove stasis, thereby improving the skin condition.

[0050] Preparation method:

[0051] Take 15 - 30 g of Astragalus membranaceus, 5 - 10 g of Red Peony Root, and 5 - 10 g of Ledebouriella seseloides;

[0052] Soak the above three herbs (depending on different treatment methods, pretreatment can be carried out first, and reference can be made to the following embodiments) in water for 30 minutes to 1 hour (use a ceramic pot or earthenware pot, avoid using metal utensils), add water and bring to a boil. The amount of water should be 2 - 3 cm higher than the herbs. First, bring to a boil over high heat, and then turn to low heat and simmer slowly for about 15 minutes. One dose is taken in two times, warm taken between meals in the morning and afternoon.

[0053] The following will provide the clinical medication data between the examples and the comparative examples.

[0054] In order to compare with the existing traditional Chinese medicine prescriptions for treating sores, the following "Xianfang Huomingyin" is used as a comparative example here: Xianfang Huomingyin is a classic prescription for treating the initial stage of sores and toxic swellings. It is mainly composed of drugs such as Angelica dahurica, Fritillaria thunbergii, Ledebouriella seseloides, Red Peony Root, Radix Angelicae Sinensis, Glycyrrhiza uralensis, Gleditsia sinensis, Manis pentadactyla, Trichosanthes kirilowii, Olibanum, Myrrha, Lonicera japonica, Citrus reticulata Blanco, etc.

[0055] For the determination methods of the effective components of traditional Chinese medicine, the following several methods can be adopted:

[0056] High Performance Liquid Chromatography (HPLC): This is one of the most commonly used methods. By using a C18 column and acetonitrile - 0.1% phosphoric acid solution as the mobile phase for gradient elution, the content of effective components in traditional Chinese medicines such as Myrsine africana can be determined. The specific steps include dissolving and extracting the test sample raw material, and then determining its HPLC chromatogram by high performance liquid chromatography to determine the component content.

[0057] Chemical analysis method: This method determines the content of effective components in traditional Chinese medicine through chemical reactions, with high accuracy and reliability.

[0058] Visible Ultraviolet Spectrophotometry: It uses the absorption characteristics of ultraviolet light to determine the content of effective components in traditional Chinese medicine, and is applicable to components with ultraviolet absorption characteristics.

[0059] Gas Chromatography: It is applicable to the determination of volatile components, and analyzes the content of volatile components in the sample through a gas chromatograph.

[0060] Thin Layer Chromatography: It separates and detects the components in traditional Chinese medicine on a thin layer plate. The commonly used quantitative methods include external standard method, overlay method and internal standard method.

[0061] Specifically, the user can select the corresponding determination method by themselves.

[0062] Example 1

[0063] Provide a traditional Chinese medicine decoction for improving skin sores of the "high - Astragalus membranaceus qi - tonifying type", which enhances the effect of supplementing qi and expelling toxins and promotes wound repair.

[0064] Ratio: Astragalus membranaceus 30g, Paeonia lactiflora 5g, Saposhnikovia divaricata 5g.

[0065] Preparation process:

[0066] Astragalus membranaceus is soaked alone for 1 hour (to promote the dissolution of saponins);

[0067] Paeonia lactiflora and Saposhnikovia divaricata are added later, brought to a boil over high heat and then simmered for 10 minutes (to protect volatile components);

[0068] The total decoction time is shortened to 12 minutes.

[0069] Limit of effective components:

[0070] Astragaloside Ⅳ ≥ 0.85mg / g (a 64% increase);

[0071] Paeoniflorin ≥ 0.9mg / g;

[0072] Prim-O-glucosylcimifugin ≥ 0.07mg / g.

[0073] The comparison of experimental data is shown in Table 1 below:

[0074]

[0075] Table 1

[0076] In contrast, this formula is superior to the comparative example in terms of the wound healing rate, the time for reducing exudate, and the granulation maturity score, etc., and can effectively promote the improvement of skin sores.

[0077] Example 2

[0078] Provide a traditional Chinese medicine decoction for improving skin sores of the "red peony root strengthening blood circulation type" to enhance the ability of promoting blood circulation to remove blood stasis and accelerate the shedding of necrotic tissue.

[0079] Ratio: Astragalus membranaceus 15g, red peony root 10g, ledebouriella root 10g

[0080] Preparation process:

[0081] Process the red peony root by stir-frying with vinegar (enhance the dissolution of paeoniflorin);

[0082] Soak the three herbs together for 50 minutes, then decoct with strong fire for 5 minutes → decoct with slow fire for 20 minutes (prolong the decocting time of red peony root);

[0083] Concentrate the decoction to 2 / 3 of the original volume.

[0084] Limit of active ingredients:

[0085] Paeoniflorin ≥ 1.8mg / g (increase by 64%);

[0086] Astragaloside IV ≥ 0.48mg / g;

[0087] Ledebouriella root polysaccharide ≥ 12mg / g (increase by 33%).

[0088] The comparison of experimental data is shown in Table 2 below:

[0089]

[0090]

[0091] Table 2

[0092] Example 3

[0093] Provide a traditional Chinese medicine decoction for improving skin sores of the "wind synergistic anti-inflammatory type" to strengthen anti-inflammatory and antibacterial effects and control wound infection.

[0094] Ratio: Astragalus membranaceus 25g, red peony root 6g, ledebouriella root 10g

[0095] Preparation process:

[0096] Ledebouriella seseloides is ultramicronized (particle size ≤ 50 μm) and decocted alone for 8 minutes;

[0097] Astragalus membranaceus and Paeonia lactiflora are decocted conventionally for 15 minutes;

[0098] After combining the medicinal liquids, boil for 3 minutes for sterilization.

[0099] Active ingredient limitation:

[0100] Hesperidin ≥ 0.15 mg / g (an increase of 87%);

[0101] Calycosin ≥ 0.3 mg / g (a secondary metabolite of Astragalus membranaceus);

[0102] Total flavonoids ≥ 4.2 mg / g.

[0103] For comparison of experimental data, see Table 3 below:

[0104]

[0105] Table 3

[0106] In the above embodiments, wound surface evaluation is performed using a skin imaging analysis system. The granulation maturity score is graded according to the "Evaluation Criteria for the Efficacy of Traditional Chinese Surgery", and the capillary density is measured by CD34 immunohistochemical staining.

[0107] Example 4

[0108] The following is a clinical case: Zhou XX, female, 89 years old, with darkening and skin breakage of both lower extremities for 5 years (as Figure 1 shown, the left side is the symptom picture before treatment and the right side is the symptom picture after treatment). The symptoms recur, and she has been taking drugs for improving blood circulation and changing dressings for symptomatic treatment all year round, but the skin improvement is not obvious. Traditional Chinese medicine considers it skin sores and ulcers. After taking this prescription for 3 months, the skin sores and ulcers have improved, mainly manifested in the wound surface shrinking and converging, the skin color improving, gradually changing from the original pitch-black to ruddy, and the dullness of skin touch being reduced.

[0109] Dosage and administration: One dose is taken in two times;

[0110] Taking time: Warmly taken between meals in the morning and afternoon, 2 times a day;

[0111] Adverse reactions: No obvious adverse reactions.

[0112] Therefore, the effects of this application are as follows: The compatibility of the three herbs strengthens the effect of Astragalus membranaceus in replenishing qi and promoting blood circulation, enabling sufficient qi and active blood, promoting qi movement, dispelling wind, and dredging collaterals, and can make the qi mechanism of the whole body smooth and promote blood circulation to remove blood stasis. This method for treating skin sores and ulcers is effective, economical, easy to obtain materials, and has a high acceptance and good compliance among patients.

[0113] It should be noted that although the above has been introduced as an example, those skilled in the art can understand that the present disclosure should not be limited thereto. In fact, users can flexibly set the preprocessing or proportioning conditions according to the actual application scenarios, as long as the technical functions of the present application can be achieved according to the above technologies.

[0114] The embodiments of the present disclosure have been described above. The above description is exemplary and not exhaustive, and is also not limited to the disclosed embodiments. Many modifications and variations are obvious to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The choice of terms used herein is intended to best explain the principles of the embodiments, the practical application, or the technical improvements to the technologies in the market, or to enable other ordinary skilled persons in the art to understand the embodiments disclosed herein.

Claims

1. A traditional Chinese medicine decoction for improving skin sores, characterized in that, The traditional Chinese medicine decoction comprises the following components in the following mass ratio: 15 - 30 g of Astragalus membranaceus, 5 - 10 g of Paeonia lactiflora, and 5 - 10 g of Saposhnikovia divaricata.

2. The preparation method of a traditional Chinese medicine decoction for improving skin sores as described in claim 1, characterized in that, It includes the following steps: Weigh 15 - 30 g of Astragalus membranaceus, 5 - 10 g of Paeonia lactiflora, and 5 - 10 g of Saposhnikovia divaricata according to the amount; Put the weighed 15 - 30 g of Astragalus membranaceus, 5 - 10 g of Paeonia lactiflora, and / or 5 - 10 g of Saposhnikovia divaricata into a decocting device and soak in water for 30 min - 1 h; After soaking, bring to a boil over high heat, then turn to low heat and decoct for 10 - 20 min; Obtain the traditional Chinese medicine decoction.

3. A traditional Chinese medicine decoction for improving skin sores, characterized in that, The traditional Chinese medicine decoction comprises the following components in the following mass ratio: 30 g of Astragalus membranaceus, 5 g of Paeonia lactiflora, and 5 g of Saposhnikovia divaricata.

4. The preparation method of a traditional Chinese medicine decoction for improving skin sores as described in claim 3, characterized in that, It includes the following steps: Weigh 30 g of Astragalus membranaceus, 5 g of Paeonia lactiflora, and 5 g of Saposhnikovia divaricata according to the amount; First, put the weighed Astragalus membranaceus into a decocting device and soak it alone in water for 1 h, then put Paeonia lactiflora and Saposhnikovia divaricata into it and soak for 30 min; After soaking, bring to a boil over high heat, then turn to low heat and decoct for 10 min; Obtain the traditional Chinese medicine decoction; Among them, the active ingredients in the traditional Chinese medicine decoction are as follows: Astragaloside Ⅳ ≥ 0.85 mg / g; Paeoniflorin ≥ 0.9 mg / g; Prim-O-glucosylcimifugin ≥ 0.07 mg / g.

5. A traditional Chinese medicine decoction for improving skin sores, characterized in that, The traditional Chinese medicine decoction comprises the following components in the following mass ratio: 15 g of Astragalus membranaceus, 10 g of Paeonia lactiflora, and 10 g of Saposhnikovia divaricata.

6. The preparation method of a traditional Chinese medicine decoction for improving skin sores as claimed in claim 5, characterized in that, It includes the following steps: Weigh 15 g of Astragalus membranaceus, 10 g of Paeonia lactiflora, and 10 g of Saposhnikovia divaricata according to the amount; First, process Paeonia lactiflora by stir-frying with vinegar, then put it together with Astragalus membranaceus and Saposhnikovia divaricata into a decocting device and soak in water for 50 min; After soaking, bring to a boil over high heat for 5 min, then turn to low heat and decoct for 15 min; Obtain the traditional Chinese medicine decoction; Among them, the active ingredients in the traditional Chinese medicine decoction are as follows: Paeoniflorin ≥ 1.8 mg / g; Astragaloside Ⅳ ≥ 0.48 mg / g; Saposhnikovia divaricata polysaccharide ≥ 12 mg / g.

7. A traditional Chinese medicine decoction for improving skin sores, characterized in that, The traditional Chinese medicine decoction comprises the following components in the following mass ratio: 25 g of Astragalus membranaceus, 6 g of Paeonia lactiflora, and 10 g of Saposhnikovia divaricata.

8. The preparation method of a traditional Chinese medicine decoction for improving skin sores as claimed in claim 7, characterized in that, It includes the following steps: Weigh 25 g of Astragalus membranaceus, 6 g of Paeonia lactiflora, and 10 g of Saposhnikovia divaricata according to the amount; First, superfine powder Saposhnikovia divaricata (particle size ≤ 50 μm) and decoct it alone for 8 min; Put Astragalus membranaceus and Paeonia lactiflora together into a decocting device and soak in water for 30 min; After soaking, add the decocted liquid of Saposhnikovia divaricata that was decocted alone, and bring to a boil over high heat for 3 min; Obtain the traditional Chinese medicine decoction; Among them, the active ingredients in the traditional Chinese medicine decoction are as follows: Prim-O-glucosylcimifugin ≥ 0.15 mg / g; Calycosin ≥ 0.3 mg / g; Total flavonoids ≥ 4.2 mg / g.

9. Use of the traditional Chinese medicine decoction according to any one of claims 1 - 8 in improving skin sores.

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