Semen ziziphi spinosae medicinal and edible composition for relieving anxiety, nourishing liver, soothing nerves and improving sleep and preparation method of semen ziziphi spinosae medicinal and edible composition

Abstract

The invention discloses a semen ziziphi spinosae medicinal and edible composition for relieving anxiety, nourishing the liver, soothing the nerves and improving sleep and a preparation method thereof, and relates to the field of traditional Chinese medicine, polygala tenuifolia, medlar, angelica sinensis and semen ziziphi spinosae are uniformly mixed, added with water, taken out, subjected to surface air-drying, frozen, then heated and dried to obtain a pretreated raw material, the pretreated raw material is soaked in a composite catalyst, heated and extracted, and the pretreated raw material is dried to obtain the medicinal and edible composition for relieving anxiety, nourishing the liver, soothing the nerves and improving sleep. Obtaining a traditional Chinese medicine extracting solution; continuously adding water into the traditional Chinese medicine extracting solution, the donkey-hide gelatin solution and the cane sugar solution, heating to boil, cooling, fixing the volume, and sterilizing to obtain the donkey-hide gelatin beverage. According to the processing and moistening principle of liquorice juice and ginger juice in the composite catalyst, particles sensitive to heating extraction temperature are cooperated, and sodium carbonate and sodium bicarbonate are adopted to adjust the pH value of carbon dioxide high-pressure extraction, so that the dissolution rate of active substances in raw material powder is greatly increased, and the exertion of active drugs of the product is improved; the performance of relieving anxiety, nourishing the liver, soothing the nerves and improving sleep of the product is greatly improved.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and particularly relates to a homologous composition of wild jujube seed for medicine and food with the functions of relieving anxiety, nourishing the liver and calming the mind, and improving sleep, and a preparation method thereof. Background Art

[0002] Wild jujube seed was first recorded in "Shennong Ben Cao Jing" and is a traditional Chinese medicine that is homologous for medicine and food. Wild jujube seed is the dried and mature seed of the plant Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow, which belongs to the liver, gallbladder, and heart meridians. It can nourish the heart yin, benefit the liver blood, and calm the mind, and is a medicine for nourishing the heart and calming the mind. In recent years, pharmacological studies have shown that wild jujube seed saponins, flavonoids, and alkaloids all have obvious sedative and hypnotic effects. The calming effect of wild jujube seed has been verified by clinical experiments. At the same time, due to the fast pace of modern people's lives and high pressure, people are prone to restlessness and insomnia. At the same time, in the current market, there are few health foods containing wild jujube seed. Therefore, it is necessary to conduct research and development on it. Summary of the Invention

[0003] The purpose of the present invention is to solve at least one of the technical problems existing in the prior art, and to provide a homologous composition of wild jujube seed for medicine and food with the functions of relieving anxiety, nourishing the liver and calming the mind, and improving sleep, and a preparation method thereof.

[0004] The technical solution of the present invention is as follows:

[0005] A preparation method of a homologous composition of wild jujube seed for medicine and food with the functions of relieving anxiety, nourishing the liver and calming the mind, and improving sleep, comprising the following steps:

[0006] S1: Mix polygala root, wolfberry fruit, Chinese angelica, and wild jujube seed, add water, take out, air-dry the surface, freeze, then heat up, dry to obtain a pretreated raw material, immerse the pretreated raw material in a composite catalyst, heat and extract, distill the extract under reduced pressure, precipitate with alcohol, filter, and distill the filtrate to remove alcohol and concentrate to obtain a traditional Chinese medicine extract;

[0007] S2: Add donkey-hide gelatin to purified water, heat and dissolve to obtain a donkey-hide gelatin solution;

[0008] S3: Dissolve sucrose in water to obtain a sucrose solution;

[0009] S4: Add the traditional Chinese medicine extract, donkey-hide gelatin solution, and sucrose solution, continue to add water, heat and boil for 20 - 40 min, cool, make up the volume, and sterilize to obtain the product.

[0010] The composite catalyst includes cellulase, ginger juice, licorice juice, sodium carbonate, sodium bicarbonate, and temperature-sensitive particles.

[0011] As a preferred embodiment of the present invention, the mass ratio of cellulase, ginger juice, licorice juice, sodium carbonate, sodium bicarbonate, and temperature-sensitive particles is 1:3 - 5:2 - 4:1:1:0.1 - 0.3.

[0012] As a preferred embodiment of the present invention, carbon dioxide is introduced while extraction is carried out, and pressure is applied simultaneously.

[0013] As a preferred embodiment of the present invention, the licorice juice is an extract obtained by water extraction of licorice; the ginger juice is an extract obtained by water extraction.

[0014] As a preferred embodiment of the present invention, the preparation method of the thermosensitive particles is as follows:

[0015] Add lotus root starch, poria cocos, and schisandra chinensis to water in a mass ratio of 1:10 - 20, and carry out hydrothermal reaction at 100 - 300 °C for 3 - 20 h; cool to room temperature, filter to obtain a precursor, and then obtain thermosensitive particles through freeze-drying.

[0016] As a preferred embodiment of the present invention, the mass ratio of the lotus root starch, poria cocos, and schisandra chinensis is 1:1 - 3:2 - 5.

[0017] As a preferred embodiment of the present invention, in step S1, air-dry on the surface until the water content is 5 - 10%.

[0018] As a preferred embodiment of the present invention, the mass ratio of polygala tenuifolia, wolfberry, angelica sinensis, and wild jujube seed is 7 - 8:5 - 7:4 - 6:8 - 9.

[0019] As a preferred embodiment of the present invention, the mass ratio of sucrose to water is 1:7 - 9; the mass ratio of donkey-hide gelatin to water is 1:6 - 8.

[0020] The present invention also discloses a homologous composition of wild jujube seed for medicine and food with the functions of relieving anxiety, nourishing the liver and calming the mind, and improving sleep, which is prepared by the above preparation method.

[0021] Furthermore, the finished dosage form of the above homologous composition of wild jujube seed for medicine and food can specifically be one of decoction, pill, tablet, capsule, granule, and oral liquid.

[0022] Even further, the application of the above homologous composition of wild jujube seed for medicine and food in the preparation of products for relieving anxiety, nourishing the liver and calming the mind, and improving sleep. Specifically, the products can be drugs or health products.

[0023] The beneficial effects of the present invention are as follows: By immersing the pretreated raw materials in a composite catalyst, according to the principle of stir-frying and moistening with licorice juice and ginger juice in the composite catalyst, synergistically with the temperature-sensitive particles for heating extraction, and adjusting the pH of high-pressure carbon dioxide extraction with sodium carbonate and sodium bicarbonate, it is more conducive to the enzymatic hydrolysis reaction of cellulase, greatly improving the dissolution rate of active substances in the raw materials, thereby enhancing the performance of the active drugs in the product and greatly improving the performance of the product in relieving anxiety, nourishing the liver and calming the mind, and improving sleep. Specific Embodiments

[0024] Embodiments of the present invention will be described in detail below. The embodiments described below are exemplary and are only used to explain the present invention, and should not be construed as a limitation of the present invention. For those without specific technical or conditions noted in the embodiments, the techniques or conditions described in the literature in the field or according to the product specifications are followed. For reagents or instruments without the manufacturer noted, they are all conventional products that can be obtained through commercial purchase.

[0025] The following embodiments specifically include the following raw materials in parts by weight: 80 parts of wild jujube seeds, 70 parts of polygala roots, 60 parts of Chinese angelica, 50 parts of wolfberries, 30 parts of donkey-hide gelatin, and 50 parts of sucrose.

[0026] Example 1

[0027] A preparation method of a homologous medicine and food composition of wild jujube seeds for relieving anxiety, nourishing the liver and calming the mind, and improving sleep, comprising the following steps:

[0028] S1: Mix polygala roots, wolfberries, Chinese angelica, and wild jujube seeds, add water, take out, air-dry the surface until the water content is 7%, freeze, then heat up and dry to obtain pretreated raw materials. Immerse the pretreated raw materials in a composite catalyst, heat and extract, distill the extract under reduced pressure, precipitate with alcohol, filter, and distill the filtrate to remove alcohol and concentrate to obtain a traditional Chinese medicine extract;

[0029] S2: Add donkey-hide gelatin to 8 times the mass of purified water, heat and dissolve to obtain a donkey-hide gelatin solution;

[0030] S3: Dissolve sucrose in 7 times the mass of water to obtain a sucrose solution;

[0031] S4: Add the traditional Chinese medicine extract, donkey-hide gelatin solution, and sucrose solution, continue to add water, heat and boil for 20 - 40 min, cool, make up the volume, and sterilize to obtain.

[0032] The composite catalyst includes cellulase, ginger juice, licorice juice, sodium carbonate, sodium bicarbonate, and thermosensitive particles with a mass ratio of 1:3:2:1:1:0.1.

[0033] Carbon dioxide is introduced while extracting, and pressure is applied simultaneously.

[0034] The licorice juice is an extract obtained by water extraction of licorice; the ginger juice is an extract obtained by water extraction.

[0035] The preparation method of the thermosensitive particles is as follows:

[0036] Add lotus root starch, poria cocos, and schisandra chinensis with a mass ratio of 1:1:2 to water at a mass ratio of 1:12, carry out hydrothermal reaction at 200 °C for 16 h; cool to room temperature, filter to obtain a precursor, and then obtain thermosensitive particles through freeze-drying.

[0037] Example 2

[0038] A preparation method of a homologous composition of Chinese medicinal and edible materials of Semen Ziziphi Spinosae for relieving anxiety, nourishing the liver and calming the mind, and improving sleep, comprising the following steps:

[0039] S1: Mix Polygala tenuifolia, Lycium barbarum, Angelica sinensis, and Semen Ziziphi Spinosae, add water, take out, air-dry the surface until the water content is 8%, freeze, then heat up, dry to obtain a pretreated raw material, immerse the pretreated raw material in a composite catalyst, heat and extract, distill the extract under reduced pressure, precipitate with alcohol, filter, and distill the filtrate to remove alcohol and concentrate to obtain a Chinese medicine extract;

[0040] S2: Add donkey-hide gelatin to 8 times the mass of purified water, heat and dissolve to obtain a donkey-hide gelatin solution;

[0041] S3: Dissolve sucrose in 7 times the mass of water to obtain a sucrose solution;

[0042] S4: Add the Chinese medicine extract, donkey-hide gelatin solution, and sucrose solution, continue to add water, heat and boil for 20 - 40 min, cool, make up the volume, and sterilize to obtain.

[0043] The composite catalyst comprises cellulase, ginger juice, licorice juice, sodium carbonate, sodium bicarbonate, and thermosensitive particles with a mass ratio of 1:3:3:1:1:0.1.

[0044] Carbon dioxide is introduced while extracting, and pressure is applied simultaneously.

[0045] The licorice juice is an extract obtained by water-extracting licorice; the ginger juice is an extract obtained by water-extracting.

[0046] The preparation method of the thermosensitive particles is as follows:

[0047] Add lotus root starch, Poria cocos, and Schisandra chinensis with a mass ratio of 1:1:3 to water at a mass ratio of 1:15, carry out a hydrothermal reaction at 200 °C for 16 h; cool to room temperature, filter to obtain a precursor, and then obtain thermosensitive particles through freeze-drying.

[0048] Example 3

[0049] A preparation method of a homologous composition of Chinese medicinal and edible materials of Semen Ziziphi Spinosae for relieving anxiety, nourishing the liver and calming the mind, and improving sleep, comprising the following steps:

[0050] S1: Mix Polygala tenuifolia, Lycium barbarum, Angelica sinensis, and Semen Ziziphi Spinosae, add water, take out, air-dry the surface until the water content is 8%, freeze, then heat up, dry to obtain a pretreated raw material, immerse the pretreated raw material in a composite catalyst, heat and extract, distill the extract under reduced pressure, precipitate with alcohol, filter, and distill the filtrate to remove alcohol and concentrate to obtain a Chinese medicine extract;

[0051] S2: Add donkey-hide gelatin to 8 times the mass of purified water, heat and dissolve to obtain a donkey-hide gelatin solution;

[0052] S3: Dissolve sucrose in 7 times its mass of water to obtain a sucrose solution;

[0053] S4: Add the traditional Chinese medicine extract, donkey-hide gelatin solution, and sucrose solution, continue to add water, heat and boil for 20 - 40 min, cool, make up the volume, sterilize, and obtain the product.

[0054] The composite catalyst includes cellulase, ginger juice, licorice juice, sodium carbonate, sodium bicarbonate, and thermosensitive particles with a mass ratio of 1:5:4:1:1:0.2.

[0055] While adding the extract, carbon dioxide is introduced and pressure is applied simultaneously.

[0056] The licorice juice is an extract obtained by extracting licorice with water; the ginger juice is an extract obtained by extracting ginger with water.

[0057] The preparation method of the thermosensitive particles is as follows:

[0058] Add lotus root starch, poria cocos, and schisandra chinensis with a mass ratio of 1:2:5 to water at a mass ratio of 1:18, carry out hydrothermal reaction at 200 °C for 18 h; cool to room temperature, filter to obtain a precursor, and then obtain the thermosensitive particles through freeze-drying.

[0059] Example 4

[0060] A preparation method of a homologous composition of wild jujube seeds for relieving anxiety, nourishing the liver and calming the mind, and improving sleep, comprising the following steps:

[0061] S1: Mix polygala tenuifolia, wolfberry, angelica sinensis, and wild jujube seeds, add water, take out, air-dry the surface until the water content is 9%, freeze, then heat up, dry to obtain a pretreated raw material, immerse the pretreated raw material in the composite catalyst, heat and extract, distill the extract under reduced pressure, carry out alcohol precipitation, filter, and distill off the alcohol and concentrate the filtrate to obtain a traditional Chinese medicine extract;

[0062] S2: Add donkey-hide gelatin to 8 times its mass of purified water, heat and dissolve to obtain a donkey-hide gelatin solution;

[0063] S3: Dissolve sucrose in 7 times its mass of water to obtain a sucrose solution;

[0064] S4: Add the traditional Chinese medicine extract, donkey-hide gelatin solution, and sucrose solution, continue to add water, heat and boil for 20 - 40 min, cool, make up the volume, sterilize, and obtain the product.

[0065] The composite catalyst includes cellulase, ginger juice, licorice juice, sodium carbonate, sodium bicarbonate, and thermosensitive particles with a mass ratio of 1:5:2:1:1:0.3.

[0066] While adding the extract, carbon dioxide is introduced and pressure is applied simultaneously.

[0067] The licorice juice is an extract obtained by extracting licorice with water; the ginger juice is an extract obtained by extracting with water.

[0068] The preparation method of the temperature-sensitive particles is as follows:

[0069] Add lotus root starch, Poria cocos, and Schisandra chinensis with a mass ratio of 1:3:5 to water at a mass ratio of 1:20, and carry out hydrothermal reaction at 200 °C for 17 h; cool to room temperature, filter to obtain a precursor, and then obtain temperature-sensitive particles through freeze-drying.

[0070] Example 5

[0071] A preparation method of a homologous composition of Chinese herbal medicines and foods with sour jujube seeds for relieving anxiety, nourishing the liver and calming the mind, and improving sleep includes the following steps:

[0072] S1: Mix polygala root, wolfberry, angelica, and sour jujube seeds, add water, take out, air-dry the surface until the water content is 10%, freeze, then heat up, dry to obtain a pretreated raw material, immerse the pretreated raw material in a composite catalyst, heat and extract, subject the extract to vacuum distillation, alcohol precipitation, filtration, and distill off the alcohol and concentrate the filtrate to obtain a Chinese herbal medicine extract;

[0073] S2: Add donkey-hide gelatin to 8 times the mass of purified water, heat and dissolve to obtain a donkey-hide gelatin solution;

[0074] S3: Dissolve sucrose in 7 times the mass of water to obtain a sucrose solution;

[0075] S4: Add the Chinese herbal medicine extract, donkey-hide gelatin solution, and sucrose solution, continue to add water, heat and boil for 20 - 40 min, cool, make up the volume, and sterilize to prepare.

[0076] The composite catalyst includes cellulase, ginger juice, licorice juice, sodium carbonate, sodium bicarbonate, and temperature-sensitive particles with a mass ratio of 1:5:4:1:1:0.2.

[0077] While adding the extract, introduce carbon dioxide and apply pressure at the same time.

[0078] The licorice juice is an extract obtained by extracting licorice with water; the ginger juice is an extract obtained by extracting with water.

[0079] The preparation method of the temperature-sensitive particles is as follows:

[0080] Add lotus root starch, Poria cocos, and Schisandra chinensis with a mass ratio of 1:3:2 to water at a mass ratio of 1:10, and carry out hydrothermal reaction at 200 °C for 10 h; cool to room temperature, filter to obtain a precursor, and then obtain temperature-sensitive particles through freeze-drying.

[0081] Blank example

[0082] Different from Example 2, the composite catalyst is water.

[0083] Comparative Example 1

[0084] Different from Example 2, the composite catalyst is ginger juice and licorice juice with a mass ratio of 1:1.

[0085] Comparative Example 2

[0086] Different from Example 2, the composite catalyst is cellulase.

[0087] Comparative Example 3

[0088] Different from Example 2, the composite catalyst is cellulase, ginger juice, licorice juice, sodium carbonate, and sodium bicarbonate in a ratio of 1:3:3:1:1.

[0089] Comparative Example 4

[0090] Different from Example 2, carbon dioxide was not simultaneously introduced during the extraction.

[0091] Performance tests were conducted on the above examples and comparative examples, and the test methods are as follows;

[0092] 1. Test the total saponin content of the samples in the above examples and comparative examples, and calculate the change rate compared with the content of the blank example. The test results are shown in Table 1.

[0093] Table 1 Performance test results of examples and comparative examples

[0094] Specimen Total saponin change rate (%) Example 1 40.5 Example 2 41.2 Example 3 40.8 Example 4 40.6 Example 5 40.1 Control Example 1 23.1 Control Example 2 18.4 Control Example 3 30.5 Control Example 4 34.2

[0095] As can be seen from the above table, the performance of the examples is better than that of the comparative examples. The main reasons may be as follows: In the examples, by impregnating the pretreated raw materials in the composite catalyst, according to the principle of stir-frying and moistening with licorice juice and ginger juice in the composite catalyst, synergistically with the sensitive particles to the heating extraction temperature, and using sodium carbonate and sodium bicarbonate to adjust the pH of the high-pressure carbon dioxide extraction, it is also more conducive to the enzymatic hydrolysis reaction of cellulase, greatly improving the dissolution rate of the active substances in the raw materials, thereby improving the performance of the active drugs in the product and greatly enhancing the performance of the product in relieving anxiety, nourishing the liver and calming the mind, and improving sleep.

[0096] 2. Sleep improvement experiment:

[0097] The sample of Example 2 above was made into oral liquid, and the recommended human dose is: 0.333 ml / kg·bw.

[0098] Experimental animals: 120 healthy male Kunming mice provided by the Experimental Animal Farm of the College of Animal Science and Technology, Hunan Agricultural University, with a body weight of 18g - 22g, and the experimental animal production license number is SCXK(Xiang)2003 - 0003.

[0099] Experimental environmental conditions: temperature 21°C - 24°C, humidity 56% - 58%. The license number for the use of experimental animals is SYXK(Xiang)2003 - 0002.

[0100] Dose selection: The experimental animals were divided into three experimental groups, denoted as Group 1 (experiment on prolonging pentobarbital sodium sleep time), Group II (pentobarbital sodium subthreshold dose hypnosis experiment), and Group III (barbital sodium sleep latency experiment). Each experimental group was randomly divided into four groups according to the animal body weight, with 10 animals in each group. According to the recommended human dose, the low, medium, and high dose groups of the test substance were set at 1.67 mL / kg·bw, 3.33 mL / kg·bw, and 10.00 mL / kg·bw respectively, approximately equivalent to 5, 10, and 30 times the recommended human dose. 16.7 mL, 33.3 mL, and 100.0 mL of the sample were taken respectively and made up to 200 mL with distilled water to prepare the required concentration. The control group was given distilled water. It was administered by gavage once a day, with a gavage volume of 0.2 mL / 10g·bw for 30 consecutive days. During the experiment, the animals were allowed to freely eat and drink water. The activities and growth of the animals were observed every day.

[0101] (1) Direct sleep experiment

[0102] Observe whether sleep occurs in the animals after administering three doses of the test sample, and the control group is given the same volume of solvent. Sleep is judged by the disappearance of the righting reflex. When the mouse is placed in the dorsal recumbent position, it can immediately right itself. If it cannot right itself within 30 - 60 seconds, it is considered that the righting reflex has disappeared and the animal has entered sleep. The recovery of the righting reflex means the animal wakes up. The time from the disappearance to the recovery of the righting reflex is the sleep time of the animal. Record the number of animals that fall asleep and the sleep time in the solvent control group and the test sample group.

[0103] (2) Experiment on prolonging pentobarbital sodium sleep time

[0104] 15 minutes after the animals were finally given the test substance, pentobarbital sodium was intraperitoneally injected into each group of animals at a dose of 42 mg / kg·bw, with an injection volume of 0.1 mL / 10g·bw. Using the disappearance of the mouse's righting reflex as the sleep index, observe the effect of the test substance on prolonging the pentobarbital sodium sleep time.

[0105] (3) Pentobarbital sodium subthreshold dose hypnosis experiment

[0106] 15 minutes after the animals were finally given the test substance, pentobarbital sodium was intraperitoneally injected into each group of animals at a dose of 30 mg / kg·bw, with an injection volume of 0.1 mL / 10g·bw. Using the disappearance of the mouse's righting reflex for more than 1 minute as the criterion for falling asleep, observe the number of animals that fall asleep within 30 minutes after giving pentobarbital sodium in each group.

[0107] (4) Fifteen minutes after the last administration of the test substance to the animals, sodium barbital was intraperitoneally injected into each group of animals at a dose of 296 mg / kg·bw, and the injection volume was 0.1 mL / 10 g. Using the disappearance of the righting reflex as an index, the effect of the test sample on the sleep latency of sodium barbital was observed.

[0108] (5) Statistical analysis and processing:

[0109] The experimental data were analyzed by variance analysis, pairwise comparison (Tukey HSD, Dunnett's T3 method) or x 2 test using Excel and SPSS 11.0 software.

[0110] 3. Test results

[0111] (1) Effect on animal body weight

[0112] Table 2 Effect of the sleep improvement (I) group on the body weight of mice

[0113] Dose group Number of animals (pcs) Initial body weight (g) Mid-term body weight (g) Final body weight (g) Control group 10 20.15±1.14 31.36±2.04 37.89±2.78 Low-dose group 10 20.15±1.10 31.44±1.91 38.17±2.51 Medium-dose group 10 20.15±0.98 30.96±1.78 37.75±2.34 High-dose group 10 20.15±1.11 31.14±1.89 38.66±2.90

[0114] Table 3 Effect of the sleep improvement (II) group on the body weight of mice

[0115] Dose group Number of animals (pcs) Initial body weight (g) Mid-term body weight (g) Final body weight (g) Control group 10 19.71±1.07 30.34±2.04 37.54±2.04 Low-dose group 10 19.69±1.01 30.22±1.83 36.80±2.34 Medium-dose group 10 19.69±0.90 31.06±2.59 38.25±3.00 High-dose group 10 19.77±1.02 30.97±1.47 38.03±2.38

[0116] Table 4 Effect of the sleep improvement (III) group on the body weight of mice

[0117] Dose group Number of animals (pcs) Initial body weight (g) Mid-term body weight (g) Final body weight (g) Control group 10 19.97±1.13 31.07±2.08 37.47±2.67 Low-dose group 10 19.95±1.12 30.30±2.37 37.45±2.49 Medium-dose group 10 20.00±0.90 30.94±1.60 36.82±2.35 High-dose group 10 20.10±1.02 31.34±1.48 38.19±2.22

[0118] As can be seen from Tables 1 - 3, there was no significant difference in body weight between the animals in the dose groups and the control group (p > 0.05); the animals grew well and no obvious abnormal reactions were observed, indicating that the present invention has the effects of relieving anxiety, nourishing the liver and calming the mind, and improving sleep.

[0119] On the premise of no conflict, those skilled in the art can freely combine and superimpose the above-mentioned additional technical features.

[0120] The above-described embodiments only represent the preferred embodiments of the present invention, and their descriptions are relatively specific and detailed, but should not be construed as limiting the scope of the patent of the present invention. It should be noted that for those of ordinary skill in the art, according to the technical solutions and concepts described above, various other corresponding changes and deformations can also be made, and all of these changes and deformations should fall within the protection scope of the claims of the present invention.

Claims

1. A preparation method of a homologous composition of Chinese wild jujube seeds for relieving anxiety, nourishing the liver and calming the mind, and improving sleep, characterized in that, It includes the following steps: S1: Mix polygala root, wolfberry fruit, angelica sinensis, and wild jujube seed, add water, take out, air-dry the surface, freeze, then heat up, dry to obtain a pretreated raw material. Immerse the pretreated raw material in a composite catalyst, heat and extract, subject the extract to vacuum distillation, alcohol precipitation, filtration, distill off the alcohol from the filtrate, and concentrate to obtain a traditional Chinese medicine extract; S2: Add donkey-hide gelatin to purified water, heat and dissolve to obtain a donkey-hide gelatin solution; S3: Dissolve sucrose in water to obtain a sucrose solution; S4: Add the traditional Chinese medicine extract, donkey-hide gelatin solution, and sucrose solution, continue to add water, heat and boil for 20 - 40 min, cool, make up the volume, sterilize to obtain; The composite catalyst includes cellulase, ginger juice, licorice juice, sodium carbonate, sodium bicarbonate, and thermosensitive particles.

2. The preparation method according to claim 1, characterized in that, The mass ratio of the cellulase, ginger juice, licorice juice, sodium carbonate, sodium bicarbonate, and thermosensitive particles is 1:3 - 5:2 - 4:1:1:0.1 - 0.

3.

3. The preparation method according to claim 1, characterized in that, Carbon dioxide is introduced while extracting, and pressure is applied simultaneously.

4. The preparation method according to claim 1, characterized in that, The licorice juice is an extract obtained by extracting licorice with water; the ginger juice is an extract obtained by extracting ginger with water.

5. The preparation method according to claim 1, characterized in that, The preparation method of the thermosensitive particles is as follows: Add lotus root starch, poria cocos, and schisandra chinensis to water in a mass ratio of 1:10 - 20, carry out hydrothermal reaction at 100 - 300 °C for 3 - 20 h; cool to room temperature, filter to obtain a precursor, and then obtain thermosensitive particles through freeze-drying.

6. The preparation method according to claim 4, wherein The mass ratio of the lotus root starch, poria cocos, and schisandra chinensis is 1:1 - 3:2 - 5.

7. The preparation method according to claim 1, wherein, In step S1, air-dry the surface until the water content is 5 - 10%.

8. The preparation method according to claim 1, wherein, The mass ratio of the polygala root, wolfberry fruit, angelica sinensis, and wild jujube seed is 7 - 8:5 - 7:4 - 6:8 - 9.

9. The preparation method according to claim 1, characterized in that, The mass ratio of sucrose to water is 1:7 - 9; the mass ratio of donkey-hide gelatin to water is 1:6 - 8.

10. A homologous composition of Chinese yam and medicine for sour jujube seeds to relieve anxiety, soothe the liver and calm the mind, and improve sleep, characterized in that, It is prepared by using the preparation method described in any one of claims 1 - 9.