Rosa roxburghii tratt fine powder and preparation process of roxburgh rose sobering and liver protecting tablet

Abstract

The invention discloses roxburgh rose fine powder and a preparation technology of roxburgh rose sobering-up and liver-protecting tablets, and particularly relates to the field of sobering-up and liver-protecting tablets.The preparation technology comprises the steps that roxburgh rose fine powder, radix puerariae, hovenia dulcis thunb, curcumin, fructus lycii and endive are selected and mixed according to the formula proportion; the mixed materials are put into a pulverizer to be pulverized for standby application; placing the crushed materials in a mixer, adding a composite adhesive according to the total weight ratio of the raw materials, and adding the composite adhesive while stirring for granulation; discharging after granulation is completed, and loading into a sub-plate for drying; putting the granulated raw materials into a drying oven for drying; if the moisture content is not more than 5%, the drying standard; and crushing the dried material again. By standardizing the pretreatment concentration of the roxburgh rose juice, optimizing the drying protection condition and standardizing the granulating and tabletting ratio, the whole-process quality control process of efficiently converting and retaining the active components and stabilizing and conforming the performance of the tablet is realized.

Description

Technical Field

[0001] The present invention relates to the technical field of hangover and liver-protecting tablets. More specifically, the present invention relates to the preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets. Background Art

[0002] Currently, in the development of hangover and liver-protecting functional foods, although a variety of plant extracts and raw materials homologous to medicine and food are widely used, the overall preparation system has significant limitations;

[0003] Existing products are mostly based on simple mixing of extracts and tablet pressing, lacking precise control over the transformation rules and retention mechanisms of active ingredients inside the raw materials. Especially when processing raw materials related to Rosa roxburghii Tratt, due to non-standard process conditions such as soluble solid content, drying method, and compounding ratio, it is extremely easy for key functional components such as flavonoids and polysaccharides to be lost in large quantities during the preparation process, resulting in large fluctuations in the content of active ingredients in the final product and insufficient functionality of the preparation;

[0004] In addition, during the tablet pressing process, due to the lack of reasonable regulation of the forming performance of wet granules and the demoulding lubricity, problems such as uneven tablet hardness, surface defects, and out-of-control disintegration often occur, further exacerbating the instability of the product in terms of function release and taking experience;

[0005] With the continuous increase in the market demand for high-efficiency and standardized hangover and liver-protecting tablets in the functional food market, the existing preparation technologies have exposed a core problem, that is, the lack of a comprehensive optimization process that can run through the whole process from raw material treatment, ingredient retention, granule forming to tablet quality control, resulting in the difficulty of efficiently retaining the active ingredients in the finished product and the difficulty of consistent and stable tablet performance. Summary of the Invention

[0006] In order to overcome the above-mentioned defects of the prior art, the embodiments of the present invention provide a preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets. By standardizing the pretreatment concentration of Rosa roxburghii Tratt juice, optimizing the drying protection conditions, and standardizing the granulation and tablet pressing ratio, a whole-process quality control process for efficient conversion and retention of active ingredients and stable and consistent tablet performance is realized to solve the problems raised in the above background art.

[0007] To achieve the above object, the present invention provides the following technical solutions: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets, including:

[0008] Raw material mixing: Select Rosa roxburghii Tratt fine powder, Pueraria lobata, Hovenia acerba Lindl., curcumin, Lycium barbarum, and Cichorium intybus L., and mix them according to the formula ratio;

[0009] Crushing: Put the mixed materials into a crusher for crushing to ensure that the powder is fine and uniform for later use;

[0010] Granulation: Place the crushed materials in a mixer, and add a composite binder according to the proportion of the total weight of the raw materials. The composite binder is added while stirring for granulation. The judgment criterion is that the raw materials can be gently kneaded into a ball, indicating qualified granulation. After granulation is completed, discharge the materials and load them into trays for drying.

[0011] Drying: Put the granulated raw materials into an oven for drying. According to the requirements of "SB / T - 10347 - 2017 - Candies - Compressed Candies", the moisture content is detected to be ≤5% as the drying standard.

[0012] Crushing: The dried materials are crushed again to ensure fine powder for subsequent tableting.

[0013] Tableting: Add magnesium stearate as a demolding agent and lubricant to the crushed materials according to the mass ratio. Adjust the pressure and tablet weight of the tableting machine, and make Rosa roxburghii Tratt hangover and liver - protecting tablets through tableting.

[0014] In a preferred embodiment, the preparation process of Rosa roxburghii Tratt fine powder includes:

[0015] Weighing: Stir the obtained Rosa roxburghii Tratt juice. After stirring, detect the soluble solids, and the soluble solids index is 9.0 - 10.0 Brix. Weigh maltodextrin for standby.

[0016] Mixing: Stir and mix maltodextrin and Rosa roxburghii Tratt juice, and detect the mixed material body. The target range of soluble solids is 21 - 22 Brix.

[0017] Spray drying: Process the mixed material body through the spray - drying process to convert it into dry powder - state Rosa roxburghii Tratt fine powder.

[0018] Material collection: Collect the dried Rosa roxburghii Tratt fine powder to form the final product.

[0019] In a preferred embodiment, select the following weight - part ratios of raw materials:

[0020] 8 - 12 parts of Rosa roxburghii Tratt fine powder; 3 - 6 parts of Pueraria lobata; 2 - 5 parts of Hovenia dulcis; 0.5 - 2 parts of curcumin; 1 - 3 parts of Lycium barbarum; 1 - 3 parts of Cichorium intybus.

[0021] In a preferred embodiment, the addition amount of the composite binder according to the weight - part ratio is: add 5 - 15 parts of the composite binder per 100 parts of raw materials.

[0022] In a preferred embodiment, tableting: Add 0.5 - 2 parts of magnesium stearate per 100 parts of raw materials to the crushed materials as a demolding agent and lubricant. Adjust the pressure of the tableting machine to 6 - 12 kN, and control the tablet weight at 0.2 - 0.5 g, and make Rosa roxburghii Tratt hangover and liver - protecting tablets through tableting.

[0023] In a preferred embodiment, 10 - 20 parts of maltodextrin are added per 100 parts of rosa roxburghii juice.

[0024] In a preferred embodiment, the mixture is processed by spray drying, and the drying temperature is controlled at 140 - 170 °C to be converted into rosa roxburghii fine powder in a dry powder state.

[0025] Technical effects and advantages of the present invention:

[0026] 1. Based on the soluble solids concentration of rosa roxburghii juice being 9.0 - 10.0 Brix, and compounding with maltodextrin to make the soluble solids of the mixture reach 21 - 22 Brix, and then by controlling the spray drying temperature within the range of 140 - 170 °C, ensuring the high - content conversion of the effective components of flavonoids and polysaccharides in rosa roxburghii fine powder. Finally, in the subsequent granulation and tableting processes, by controlling the addition amount of 5 - 15 parts of compound binder and 0.5 - 2 parts of magnesium stearate, the finished product consistency and active function indexes of rosa roxburghii hangover and liver - protecting tablets are improved, and the problems of component loss, poor tablet forming, and function fluctuation in the prior art are solved;

[0027] 2. By combining 8 - 12 parts of rosa roxburghii fine powder, 3 - 6 parts of pueraria lobata, 2 - 5 parts of hovenia dulcis, 0.5 - 2 parts of curcumin, 1 - 3 parts of wolfberry, and 1 - 3 parts of chicory in the raw material formula, a multi - component complementary and synergistic system is formed, which bidirectionally activates the alcohol metabolism pathway and the liver protection mechanism, significantly improves the activities of alcohol dehydrogenase and aldehyde dehydrogenase, and enhances the overall functional effect;

[0028] 3. In the present invention, wet granulation is carried out at a compound binder ratio of 5 - 15% of the total raw material amount in the granulation stage, combined with a drying standard with the moisture content controlled at ≤5%, ensuring uniform particle size distribution and good tablet compressibility, improving the tableting efficiency and tablet hardness, and avoiding tablet fragmentation caused by poor granulation;

[0029] 4. In the present invention, 0.5 - 2 parts of magnesium stearate are added as a demolding lubricant per 100 parts of raw materials during the tableting process, the pressure of the tableting machine is adjusted to 6 - 12 kN, and the tablet weight is controlled between 0.2 - 0.5 g, ensuring that the tablet surface is smooth and complete, the demolding is smooth, and the disintegration time is reasonable, which is beneficial to improving the tablet taking experience and bioavailability;

[0030] 5. By designing multiple groups of examples and comparative examples, and detecting the changes in the flavonoid content, polysaccharide content, alcohol dehydrogenase and aldehyde dehydrogenase activities of the finished products under different disturbance conditions such as the absence of rosa roxburghii fine powder, the overdose of hovenia dulcis, and the low spray drying temperature, the response relationship between process parameters and function indexes is established, verifying the effectiveness and authenticity of the overall preparation process. Brief Description of the Drawings

[0031] Figure 1This is the process flow chart of the preparation of the present invention. Detailed implementation manners

[0032] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0033] Refer to the attached Figure 1 description, the preparation processes of the Rosa roxburghii Tratt fine powder and the Rosa roxburghii Tratt hangover and liver-protecting tablets of the present invention include: Examples A1 - A6, according to the change of the main formula (small range fluctuation of Rosa roxburghii Tratt fine powder, Pueraria lobata, and Hovenia dulcis); Examples B1 - B3, according to the change of the proportion of the composite binder (three levels of low, medium, and high); Examples C1 - C3, according to the combination change of drying temperature, tableting pressure, and tablet weight; Comparative Examples D1 - D5, for comparison according to the lack of key components, mismatch of ratios, deviation of drying temperature, etc.

[0034] Example A1: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets includes:

[0035] Raw material mixing: Select 10 parts of Rosa roxburghii Tratt fine powder, 4 parts of Pueraria lobata, 3 parts of Hovenia dulcis, 1 part of curcumin, 2 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio;

[0036] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0037] Granulation: Place the crushed materials in a mixer, add 10 parts of the composite binder according to the total weight ratio of the raw materials, and add the composite binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0038] Drying: Put the granulated raw materials into an oven for drying, and the detection moisture content ≤ 5% is the drying standard;

[0039] Crushing: The dried materials are crushed again;

[0040] Tableting: Add 1 part of magnesium stearate to every 100 parts of the raw materials in the crushed materials as a demolding agent and lubricant; Adjust the pressure of the tableting machine to 8 kN, and control the tablet weight at 0.3 g, and make Rosa roxburghii Tratt hangover and liver-protecting tablets through tableting.

[0041] Example A2: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets includes:

[0042] Raw material mixing: Select 12 parts of Rosa roxburghii Tratt fine powder, 5 parts of Pueraria lobata, 4 parts of Hovenia acerba Lindl., 1.5 parts of curcumin, 2 parts of Lycium barbarum, and 1 part of Cichorium intybus, and mix them according to the formula ratio;

[0043] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0044] Granulation: Place the crushed materials in a mixer, add 12 parts of composite binder according to the total weight ratio of the raw materials, and add the composite binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0045] Drying: Put the granulated raw materials into an oven for drying, and the moisture content is detected to be ≤5% as the drying standard;

[0046] Crushing: Crush the materials again after drying is completed;

[0047] Tabletting: Add 1.5 parts of magnesium stearate to every 100 parts of the crushed materials as a mold release agent and lubricant; Adjust the pressure of the tabletting machine to 10 kN, and control the tablet weight at 0.4 g, and make Rosa roxburghii Tratt hangover and liver-protecting tablets through tabletting.

[0048] Example A3: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets, including:

[0049] Raw material mixing: Select 8 parts of Rosa roxburghii Tratt fine powder, 3 parts of Pueraria lobata, 2 parts of Hovenia acerba Lindl., 0.5 parts of curcumin, 1 part of Lycium barbarum, and 3 parts of Cichorium intybus, and mix them according to the formula ratio;

[0050] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0051] Granulation: Place the crushed materials in a mixer, add 8 parts of composite binder according to the total weight ratio of the raw materials, and add the composite binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0052] Drying: Put the granulated raw materials into an oven for drying, and the moisture content is detected to be ≤5% as the drying standard;

[0053] Crushing: Crush the materials again after drying is completed;

[0054] Tabletting: Add 0.8 parts of magnesium stearate to every 100 parts of the crushed materials as a mold release agent and lubricant; Adjust the pressure of the tabletting machine to 7 kN, and control the tablet weight at 0.25 g, and make Rosa roxburghii Tratt hangover and liver-protecting tablets through tabletting.

[0055] Example A4: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets, including:

[0056] Raw material mixing: Select 9 parts of Rosa roxburghii Tratt fine powder, 6 parts of Pueraria lobata, 5 parts of Hovenia dulcis Thunb, 2 parts of curcumin, 3 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio;

[0057] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0058] Granulation: Place the crushed materials in a mixer, add 14 parts of compound binder according to the total weight ratio of the raw materials, and add the compound binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0059] Drying: Put the granulated raw materials into an oven for drying, and the drying standard is that the moisture content is detected to be ≤5%;

[0060] Crushing: Crush the materials again after drying is completed;

[0061] Tabletting: Add 1.8 parts of magnesium stearate to every 100 parts of the raw materials in the crushed materials as a release agent and lubricant; Adjust the pressure of the tabletting machine to 11 kN, control the tablet weight at 0.45 g, and make Rosa roxburghii Tratt hangover and liver-protecting tablets by tabletting.

[0062] Example A5: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets, including:

[0063] Raw material mixing: Select 11 parts of Rosa roxburghii Tratt fine powder, 3 parts of Pueraria lobata, 2 parts of Hovenia dulcis Thunb, 1 part of curcumin, 2 parts of Lycium barbarum, and 3 parts of Cichorium intybus, and mix them according to the formula ratio;

[0064] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0065] Granulation: Place the crushed materials in a mixer, add 9 parts of compound binder according to the total weight ratio of the raw materials, and add the compound binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0066] Drying: Put the granulated raw materials into an oven for drying, and the drying standard is that the moisture content is detected to be ≤5%;

[0067] Crushing: Crush the materials again after drying is completed;

[0068] Tabletting: Add 1 part of magnesium stearate to every 100 parts of the raw materials in the crushed materials as a release agent and lubricant; Adjust the pressure of the tabletting machine to 9 kN, control the tablet weight at 0.35 g, and make Rosa roxburghii Tratt hangover and liver-protecting tablets by tabletting.

[0069] Example A6: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets, including:

[0070] Raw material mixing: Select 8 parts of Rosa roxburghii Tratt fine powder, 5 parts of Pueraria lobata, 4 parts of Hovenia dulcis Thunb., 1.5 parts of curcumin, 3 parts of Lycium barbarum, and 1 part of Cichorium intybus, and mix them according to the formula ratio;

[0071] Crushing: Put the mixed materials into a crusher for crushing and set aside for use;

[0072] Granulation: Place the crushed materials in a mixer, add 11 parts of compound binder according to the total weight ratio of the raw materials, and add the compound binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0073] Drying: Put the granulated raw materials into an oven for drying, and the detection moisture content ≤ 5% is the drying standard;

[0074] Crushing: Crush the materials again after drying;

[0075] Tabletting: Add 1.2 parts of magnesium stearate to every 100 parts of the raw materials in the crushed materials as a release agent and lubricant; Adjust the pressure of the tabletting machine to 8 kN, control the tablet weight at 0.3 g, and make Rosa roxburghii Tratt hangover and liver-protecting tablets through tabletting.

[0076] Example B1: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets, including:

[0077] Raw material mixing: Select 10 parts of Rosa roxburghii Tratt fine powder, 4 parts of Pueraria lobata, 3 parts of Hovenia dulcis Thunb., 1 part of curcumin, 2 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio;

[0078] Crushing: Put the mixed materials into a crusher for crushing and set aside for use;

[0079] Granulation: Place the crushed materials in a mixer, add 5 parts of compound binder according to the total weight ratio of the raw materials, and add the compound binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0080] Drying: Put the granulated raw materials into an oven for drying, and the detection moisture content ≤ 5% is the drying standard;

[0081] Crushing: Crush the materials again after drying;

[0082] Tabletting: Add 0.5 parts of magnesium stearate to every 100 parts of the raw materials in the crushed materials as a release agent and lubricant; Adjust the pressure of the tabletting machine to 7 kN, control the tablet weight at 0.25 g, and make Rosa roxburghii Tratt hangover and liver-protecting tablets through tabletting.

[0083] Example B2: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets, including:

[0084] Raw material mixing: Select 10 parts of Rosa roxburghii Tratt fine powder, 4 parts of Pueraria lobata, 3 parts of Hovenia acerba Lindl., 1 part of curcumin, 2 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio;

[0085] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0086] Granulation: Place the crushed materials in a mixer, add 10 parts of compound binder according to the total weight ratio of the raw materials, and add the compound binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0087] Drying: Put the granulated raw materials into an oven for drying, and the drying standard is that the moisture content is detected to be ≤5%;

[0088] Crushing: Crush the materials again after drying is completed;

[0089] Tabletting: Add 1 part of magnesium stearate to every 100 parts of the raw materials in the crushed materials as a release agent and lubricant; Adjust the pressure of the tabletting machine to 8 kN, control the tablet weight at 0.3 g, and make Rosa roxburghii Tratt hangover and liver-protecting tablets through tabletting.

[0090] Example B3: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets, including:

[0091] Raw material mixing: Select 10 parts of Rosa roxburghii Tratt fine powder, 4 parts of Pueraria lobata, 3 parts of Hovenia acerba Lindl., 1 part of curcumin, 2 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio;

[0092] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0093] Granulation: Place the crushed materials in a mixer, add 15 parts of compound binder according to the total weight ratio of the raw materials, and add the compound binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0094] Drying: Put the granulated raw materials into an oven for drying, and the drying standard is that the moisture content is detected to be ≤5%;

[0095] Crushing: Crush the materials again after drying is completed;

[0096] Tabletting: Add 2 parts of magnesium stearate to every 100 parts of the raw materials in the crushed materials as a release agent and lubricant; Adjust the pressure of the tabletting machine to 10 kN, control the tablet weight at 0.4 g, and make Rosa roxburghii Tratt hangover and liver-protecting tablets through tabletting.

[0097] Example C1: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver-protecting tablets, including:

[0098] Raw material mixing: Select 10 parts of Rosa roxburghii Tratt fine powder, 4 parts of Pueraria lobata, 3 parts of Hovenia acerba Lindl., 1 part of curcumin, 2 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio;

[0099] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0100] Granulation: Place the crushed materials in a mixer, add 10 parts of composite binder according to the total weight ratio of the raw materials, and add the composite binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0101] Drying: Put the granulated raw materials into an oven for drying, and the drying standard is that the moisture content is detected to be ≤5%;

[0102] Crushing: Crush the dried materials again;

[0103] Tabletting: Add 1 part of magnesium stearate to every 100 parts of the crushed materials as a mold release agent and lubricant; Adjust the pressure of the tabletting machine to 6 kN, control the tablet weight at 0.2 g, and make Rosa roxburghii Tratt hangover and liver protection tablets by tabletting;

[0104] During the preparation process of Rosa roxburghii Tratt fine powder, the spray drying temperature is set at 140 °C.

[0105] Example C2: A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver protection tablets, including:

[0106] Raw material mixing: Select 10 parts of Rosa roxburghii Tratt fine powder, 4 parts of Pueraria lobata, 3 parts of Hovenia acerba Lindl., 1 part of curcumin, 2 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio;

[0107] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0108] Granulation: Place the crushed materials in a mixer, add 10 parts of composite binder according to the total weight ratio of the raw materials, and add the composite binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying;

[0109] Drying: Put the granulated raw materials into an oven for drying, and the drying standard is that the moisture content is detected to be ≤5%;

[0110] Crushing: Crush the dried materials again;

[0111] Tabletting: Add 1 part of magnesium stearate to every 100 parts of the crushed materials as a mold release agent and lubricant; Adjust the pressure of the tabletting machine to 9 kN, control the tablet weight at 0.35 g, and make Rosa roxburghii Tratt hangover and liver protection tablets by tabletting;

[0112] During the preparation process of Rosa roxburghii Tratt fine powder, the spray drying temperature is set at 155 °C.

[0113] Example C3: Preparation process of Rosa roxburghii tratt fine powder and Rosa roxburghii tratt hangover and liver-protecting tablets, including:

[0114] Raw material mixing: Select 10 parts of Rosa roxburghii tratt fine powder, 4 parts of Pueraria lobata, 3 parts of Hovenia dulcis, 1 part of curcumin, 2 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio;

[0115] Crushing: Put the mixed materials into a crusher for crushing, and set aside for use;

[0116] Granulation: Place the crushed materials in a mixer, add 10 parts of compound binder according to the total weight ratio of the raw materials, and add the compound binder while stirring for granulation; After granulation is completed, discharge the materials, load them into trays and prepare for drying;

[0117] Drying: Put the granulated raw materials into an oven for drying, and the drying standard is that the moisture content is detected to be ≤5%;

[0118] Crushing: Crush the materials after drying again;

[0119] Tabletting: Add 1 part of magnesium stearate to every 100 parts of the raw materials in the crushed materials as a mold release agent and lubricant; Adjust the pressure of the tabletting machine to 12 kN, control the tablet weight at 0.5 g, and make Rosa roxburghii tratt hangover and liver-protecting tablets through tabletting;

[0120] During the preparation process of Rosa roxburghii tratt fine powder, the spray drying temperature is set at 170 °C.

[0121] Control group D1 (lack of Rosa roxburghii tratt fine powder); In the actual measurement, after the lack of Rosa roxburghii tratt fine powder, the flavonoids and polysaccharides decreased significantly, resulting in weakened functions;

[0122] A preparation process of Rosa roxburghii tratt fine powder and Rosa roxburghii tratt hangover and liver-protecting tablets, including:

[0123] Raw material mixing: Select 4 parts of Pueraria lobata, 3 parts of Hovenia dulcis, 1 part of curcumin, 2 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio (without adding Rosa roxburghii tratt fine powder);

[0124] Crushing: Put the mixed materials into a crusher for crushing, and set aside for use;

[0125] Granulation: Place the crushed materials in a mixer, add 10 parts of compound binder according to the total weight ratio of the raw materials, and add the compound binder while stirring for granulation; After granulation is completed, discharge the materials, load them into trays and prepare for drying;

[0126] Drying: Put the granulated raw materials into an oven for drying, and the drying standard is that the moisture content is detected to be ≤5%;

[0127] Crushing: Crush the materials after drying again;

[0128] Tabletting: Add 1 part of magnesium stearate per 100 parts of raw materials to the crushed material as a mold release agent and lubricant; adjust the pressure of the tabletting machine to 8 kN, control the tablet weight at 0.3 g, and make Rosa roxburghii Tratt hangover and liver protection tablets by tabletting.

[0129] Comparative example D2 (excessive Hovenia dulcis Thunb.); in the actual measurement, the bitterness increases after the excessive amount of Hovenia dulcis Thunb., affecting the taste and compliance of taking.

[0130] A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver protection tablets includes:

[0131] Raw material mixing: Select 10 parts of Rosa roxburghii Tratt fine powder, 4 parts of Pueraria lobata (Willd.) Ohwi, 10 parts of Hovenia dulcis Thunb., 1 part of curcumin, 2 parts of Lycium barbarum L., and 2 parts of Cichorium intybus L., and mix them according to the formula ratio (excessive Hovenia dulcis Thunb.);

[0132] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0133] Granulation: Place the crushed materials in a mixer, add 10 parts of composite binder according to the total weight ratio of the raw materials, and add the composite binder while stirring for granulation; after granulation is completed, discharge the materials and load them into trays for drying;

[0134] Drying: Put the granulated raw materials into an oven for drying, and take the moisture content ≤ 5% as the drying standard;

[0135] Crushing: Crush the materials after drying again;

[0136] Tabletting: Add 1 part of magnesium stearate per 100 parts of raw materials to the crushed material as a mold release agent and lubricant; adjust the pressure of the tabletting machine to 8 kN, control the tablet weight at 0.3 g, and make Rosa roxburghii Tratt hangover and liver protection tablets by tabletting.

[0137] Comparative example D3 (too low spray drying temperature); in the actual measurement, low-temperature spraying leads to incomplete drying and the quality of the fine powder decreases;

[0138] A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver protection tablets includes:

[0139] Raw material mixing: Select 10 parts of Rosa roxburghii Tratt fine powder, 4 parts of Pueraria lobata (Willd.) Ohwi, 3 parts of Hovenia dulcis Thunb., 1 part of curcumin, 2 parts of Lycium barbarum L., and 2 parts of Cichorium intybus L., and mix them according to the formula ratio;

[0140] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0141] Granulation: Place the crushed materials in a mixer, add 10 parts of composite binder according to the total weight ratio of the raw materials, and add the composite binder while stirring for granulation; after granulation is completed, discharge the materials and load them into trays for drying;

[0142] Drying: Put the granulated raw materials into an oven for drying. The drying standard is that the detected moisture content ≤ 5%;

[0143] Crushing: The dried materials are crushed again;

[0144] Tablet pressing: Add 1 part of magnesium stearate to every 100 parts of raw materials in the crushed materials as a mold release agent and lubricant; Adjust the pressure of the tablet press to 8 kN, and control the tablet weight at 0.3 g. The Rosa roxburghii Tratt hangover and liver protection tablets are made by tablet pressing;

[0145] During the preparation process of the Rosa roxburghii Tratt fine powder, the spray drying temperature is set at 120 °C (lower than the normal range).

[0146] Control group D4 (insufficient composite binder); Insufficient binder results in loose particles and insufficient tablet hardness;

[0147] A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver protection tablets includes:

[0148] Raw material mixing: Select 10 parts of Rosa roxburghii Tratt fine powder, 4 parts of Pueraria lobata, 3 parts of Hovenia dulcis, 1 part of curcumin, 2 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio;

[0149] Crushing: Put the mixed materials into a crusher for crushing and set aside;

[0150] Granulation: Put the crushed materials into a mixer, add 2 parts of composite binder (lower than the standard value) according to the total weight ratio of the raw materials, and add the composite binder while stirring for granulation; After granulation is completed, discharge the materials, load them into trays and prepare for drying;

[0151] Drying: Put the granulated raw materials into an oven for drying. The drying standard is that the detected moisture content ≤ 5%;

[0152] Crushing: The dried materials are crushed again;

[0153] Tablet pressing: Add 1 part of magnesium stearate to every 100 parts of raw materials in the crushed materials as a mold release agent and lubricant; Adjust the pressure of the tablet press to 8 kN, and control the tablet weight at 0.3 g. The Rosa roxburghii Tratt hangover and liver protection tablets are made by tablet pressing.

[0154] Control group D5 (excessive magnesium stearate); Excessive magnesium stearate results in the accumulation of the lubricating layer on the tablet surface and the extension of the disintegration time;

[0155] A preparation process of Rosa roxburghii Tratt fine powder and Rosa roxburghii Tratt hangover and liver protection tablets includes:

[0156] Raw material mixing: Select 10 parts of Rosa roxburghii Tratt fine powder, 4 parts of Pueraria lobata, 3 parts of Hovenia dulcis, 1 part of curcumin, 2 parts of Lycium barbarum, and 2 parts of Cichorium intybus, and mix them according to the formula ratio;

[0157] Crushing: Put the mixed materials into a crusher for crushing and set aside for use;

[0158] Granulation: Place the crushed materials in a mixer, add 10 parts of a composite binder according to the total weight ratio of the raw materials, and add the composite binder while stirring to granulate; After granulation is completed, discharge the materials and load them into trays for drying;

[0159] Drying: Put the granulated raw materials into an oven for drying, and use the detection of moisture content ≤ 5% as the drying standard;

[0160] Crushing: Crush the materials again after drying is completed;

[0161] Tabletting: Add 5 parts of magnesium stearate (exceeding the standard) to every 100 parts of the raw materials in the crushed materials as a mold release agent and lubricant; Adjust the pressure of the tabletting machine to 8 kN, control the tablet weight at 0.3 g, and make Rosa roxburghii Tratt hangover and liver protection tablets through tabletting.

[0162] Table 1: Table of raw material formula ratios and preparation parameters

[0163]

[0164]

[0165]

[0166] Table 2: Detection table of soluble solids in Rosa roxburghii Tratt fine powder

[0167]

[0168]

[0169] Table 3: Detection table of moisture content in Rosa roxburghii Tratt hangover and liver protection tablets

[0170]

[0171] Table 4: Determination table of flavonoid content in Rosa roxburghii Tratt hangover and liver protection tablets

[0172]

[0173]

[0174] Table 5: Determination table of polysaccharide content in Rosa roxburghii Tratt hangover and liver protection tablets

[0175]

[0176]

[0177] Table 6: Detection table of alcohol dehydrogenase activity

[0178]

[0179]

[0180] Table 7: Detection Table of Glutamic Pyruvic Transaminase (ALT) Activity

[0181]

[0182]

[0183] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. Preparation process of Rosa roxburghii tratt fine powder and Rosa roxburghii tratt hangover and liver-protecting tablets, characterized in that, Including: Raw material mixing: Select rose roxburghii Tratt fine powder, kudzu root,hovenia dulcis, curcumin, wolfberry, and chicory, and mix them according to the formula ratio; Crushing: Put the mixed materials into a crusher for crushing and set aside; Granulation: Place the crushed materials in a mixer, add a composite binder according to the proportion of the total weight of the raw materials, and add the composite binder while stirring for granulation; After granulation is completed, discharge the materials and load them into trays for drying; Drying: Put the granulated raw materials into an oven for drying; The moisture content is detected to be ≤5% as the drying standard; Crushing: The materials after drying are crushed again; Tabletting: Add magnesium stearate to the crushed materials according to the mass ratio as a release agent and lubricant; Adjust the pressure and tablet weight of the tabletting machine, and make rose roxburghii Tratt hangover and liver protection tablets by tabletting.

2. The preparation process of the Rosa roxburghii tratt fine powder and the Rosa roxburghii tratt hangover and liver-protecting tablets according to claim 1, characterized in that, The preparation process of rose roxburghii Tratt fine powder includes: Weighing: Stir the obtained rose roxburghii Tratt juice; After stirring, detect the soluble solids, and the soluble solids index is 9.0 - 10.0 Brix; Weigh and reserve maltodextrin; Mixing: Stir and mix maltodextrin and rose roxburghii Tratt juice, and detect the mixture, and the target range of soluble solids is 21 - 22 Brix; Spray drying: Process the mixture through the spray drying process to convert it into rose roxburghii Tratt fine powder in a dry powder state; Material collection: Collect the dried rose roxburghii Tratt fine powder to form the final product.

3. The preparation process of the Rosa roxburghii tratt fine powder and the Rosa roxburghii tratt hangover and liver-protecting tablets according to claim 2, wherein Select the following weight ratio of raw materials: 8 - 12 parts of rose roxburghii Tratt fine powder; 3 - 6 parts of kudzu root; 2 - 5 parts of hovenia dulcis; 0.5 - 2 parts of curcumin; 1 - 3 parts of wolfberry; 1 - 3 parts of chicory.

4. The preparation process of rose roxburghii Tratt fine powder and rose roxburghii Tratt hangover and liver protection tablets according to claim 3, characterized in that: The addition amount of the composite binder according to the weight ratio is: Add 5 - 15 parts of the composite binder to every 100 parts of raw materials.

5. The preparation process of rose roxburghii Tratt fine powder and rose roxburghii Tratt hangover and liver protection tablets according to claim 4, characterized in that: Tabletting: Add 0.5 - 2 parts of magnesium stearate to every 100 parts of raw materials in the crushed materials as a release agent and lubricant; Adjust the pressure of the tabletting machine to 6 - 12 kN, and control the tablet weight at 0.2 - 0.5 g, and make rose roxburghii Tratt hangover and liver protection tablets by tabletting.

6. The preparation process of the Rosa roxburghii Tratt fine powder and the Rosa roxburghii Tratt hangover and liver-protecting tablets according to claim 5, wherein: According to every 100 parts of rose roxburghii Tratt juice, add 10 - 20 parts of maltodextrin.

7. The preparation process of the Rosa roxburghii tratt fine powder and the Rosa roxburghii tratt hangover and liver-protecting tablets according to claim 6, wherein: Process the mixture through the spray drying process, and control the drying temperature at 140 - 170 °C to convert it into rose roxburghii Tratt fine powder in a dry powder state.

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