Refreshing slow-release aromatherapy and preparation process thereof

Abstract

The invention provides refreshing slow-release aromatherapy and a preparation process thereof, and relates to the technical field of aromatherapy essential oil. The aromatherapy product is prepared from the following raw materials in parts by weight: 1.5 to 2.5 parts of perfume, 1.5 to 3 parts of mesoporous silica nanoparticles, 1.2 to 2 parts of modified cyclodextrin, 1 to 1.5 parts of chitosan, 3 to 8 parts of glycerol, 12 to 18 parts of 1, 3-butanediol, 8 to 15 parts of propylene glycol and 55 to 75 parts of deionized water. According to the invention, layered release and long-acting stability of aroma components are realized through a triple slow-release technology of nanopore adsorption, intelligent gel film control and volatile gradient adjustment. In actual use, the fragrance release intensity can be flexibly controlled by replacing the fiber rod or adjusting the size of the volatilization opening, and the refreshing device is suitable for refreshing requirements of multiple scenes such as vehicle-mounted, office and learning.

Description

Technical Field

[0001] This application relates to the technical field of aromatherapy essential oils. Specifically, it relates to a refreshing slow-release aromatherapy and its preparation process. Background Art

[0002] With the continuous improvement of people's attention to the quality of life and health, liquid aromatherapy, as an aromatic product with both decorative and practical functions, has gradually become a popular choice for improving the environmental atmosphere and regulating emotions. Liquid aromatherapy mainly diffuses the fragrance into the surrounding space by volatilizing the fragrance components in the solvent. Compared with solid aromatherapy and aromatherapy candles, its fragrance release is more uniform and gentle, and it is easy to use. Just by matching with diffusion tools such as rattan strips and fiber rods, it can continuously emit fragrance.

[0003] In terms of application scenarios, liquid aromatherapy has wide applicability. In the home environment, it can be used in the living room, bedroom and study. It can not only purify the air, remove odors, but also create a warm and comfortable atmosphere, helping to relax the body and mind and relieve stress; in the workplace, refreshing liquid aromatherapy can effectively improve concentration and work efficiency, and reduce fatigue; in commercial spaces, such as hotel lobbies, restaurants, yoga studios, etc., customized liquid aromatherapy helps to shape a unique brand olfactory identity and enhance the customer's environmental experience; in the in-vehicle scenario, small liquid aromatherapy can improve the smell in the small space of the car, and the refreshing aromatherapy can also help the driver stay awake and improve driving safety.

[0004] However, the current liquid aromatherapy products on the market still have deficiencies in long-term slow release and functionality. Traditional liquid aromatherapy mostly uses a single solvent (such as 1,3-butanediol) to dissolve essential oils. The too-fast volatility leads to a short fragrance duration, often only lasting for a few hours, which is difficult to meet the long-term use requirements. For some products with slow-release materials added, they often use a single carrier such as diatomite or ordinary cyclodextrin. The essential oil loading capacity is limited, and the release rate cannot be intelligently adjusted according to environmental changes, resulting in too strong fragrance at the initial stage and insufficient fragrance at the later stage, causing olfactory fatigue and fragrance waste. In terms of ingredients, the existing refreshing aromatherapy mostly relies on single fragrance components such as mint and lemon, lacking fragrance layers and multi-sensory synergistic effects. Long-term use is likely to cause olfactory adaptation, and the refreshing effect gradually weakens. In addition, the slow-release technology used in some products only delays volatilization from the perspective of physical adsorption, without considering the synergistic effect and stability between fragrance molecules, resulting in the oxidation and deterioration of fragrance components during storage, affecting the product quality and service life. Therefore, developing a liquid aromatherapy formula and process with a multi-level slow-release structure, capable of realizing layered fragrance release and multi-sensory synergistic refreshing, and having long-term stable performance, has become an urgent problem to be solved. Summary of the Invention

[0005] The purpose of this application is to provide a refreshing slow-release aromatherapy, which has the advantages of refreshing the mind and slowly and controllably releasing fragrance.

[0006] To solve the above technical problems, the technical solution adopted in this application is as follows:

[0007] On the one hand, this application provides a refreshing slow-release aromatherapy. Calculated by weight parts, the aromatherapy includes the following raw materials: 1.5 - 2.5 parts of fragrance, 1.5 - 3 parts of mesoporous silica nanoparticles, 1.2 - 2 parts of modified cyclodextrin, 1 - 1.5 parts of chitosan, 3 - 8 parts of glycerol, 12 - 18 parts of 1,3 - butanediol, 8 - 15 parts of propylene glycol, and 55 - 75 parts of deionized water.

[0008] On the other hand, this application provides a preparation method of a refreshing slow-release aromatherapy, which includes the following steps:

[0009] S1. Mix grapefruit essential oil, green mint essential oil and mesoporous silica nanoparticles, and perform ultrasonic oscillation to obtain mixture I;

[0010] S2. Add rosemary CO2 extract and juniper essential oil to deionized water, and then slowly pour in modified cyclodextrin and stir to obtain mixture II;

[0011] S3. Dissolve chitosan in acetic acid solution, then add glycerol, propylene glycol, mixture I and mixture II, and perform homogeneous dispersion to obtain mixture III;

[0012] S4. Add 1,3 - butanediol, cedar seed oil, and menthol microcrystals to mixture III, continuously stir to form a homogeneous system, and finally adjust the pH to 5.3 - 5.6, and let it stand to obtain the refreshing slow-release aromatherapy.

[0013] Compared with the prior art, the embodiments of this application at least have the following advantages or beneficial effects:

[0014] 1. This application uses the fragrance compounding of "top note - middle note - base note" to make the aromatherapy have the effect of refreshing the mind. Specifically, the compatibility of traditional Chinese medicine fragrances follows the principle of "sovereign, minister, assistant, and guide" in traditional Chinese medicine, forming a multi-sensory synergistic effect in terms of smell and touch, conforming to the health concept of "nourishing both body and mind" in traditional Chinese medicine, improving the mental state of the human body as a whole, and achieving the refreshing effect of "regulating from within and nourishing from outside, vibrating both body and mind".

[0015] 2. Through the triple slow-release technology of "nanochannel adsorption-intelligent gel film control-volatile gradient regulation", the present application realizes the hierarchical release and long-term stability of aroma components. In the compound system of the present application: 1. Mesoporous silica improves the essential oil loading capacity and protects the active ingredients; 2. Modified cyclodextrin enhances the water-soluble inclusion of hydrophobic essential oils; 3. The pH-responsive film formed by chitosan can adaptively adjust the release rate according to the environmental humidity (such as the office air-conditioning environment and the indoor natural environment); 4. The slow-release dissolution of menthol microcrystals provides a continuous cooling sensation, forming a multi-sensory synergistic effect with olfactory refreshing.

[0016] During actual use, the aroma release intensity can be flexibly controlled by replacing the fiber rod or adjusting the size of the volatilization port, which is suitable for the refreshing needs in multiple scenarios such as in-vehicle, office, and study. Detailed implementation manners

[0017] To make the objectives, technical solutions, and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. For those conditions not specified in the embodiments, they are carried out according to conventional conditions or the conditions recommended by the manufacturer. For the reagents or instruments not specified by the manufacturer, they are all conventional products that can be obtained through commercial purchase.

[0018] It should be noted that, without conflict, the embodiments in the present application and the features in the embodiments can be combined with each other. The present application will be described in detail below with reference to specific embodiments.

[0019] A refreshing slow-release aromatherapy, in parts by weight, the aromatherapy includes the following raw materials: 1.5-2.5 parts of spice, 1.5-3 parts of mesoporous silica nanoparticles, 1.2-2 parts of modified cyclodextrin, 1-1.5 parts of chitosan, 3-8 parts of glycerol, 12-18 parts of 1,3-butanediol, 8-15 parts of propylene glycol, and 55-75 parts of deionized water.

[0020] In the present application, modified cyclodextrin provides a hydrophobic environment to enhance the stability of essential oil inclusion. Chitosan (degree of deacetylation 90%) has pH responsiveness to form a film and adjusts the release rate in response to changes in air humidity. Glycerol is a humectant that delays the drying and hardening of the chitosan film. 1,3-butanediol is a colorless, transparent liquid with a special odor. It has good moisture retention performance and solubility, can evenly disperse the spice in water, and has little skin irritation and high safety. When used in aromatherapy, it can make the aroma emit gently and lastingly. Propylene glycol is a low-volatility solvent that balances the overall volatilization curve. Deionized water adjusts the polarity of the system and controls the slow-release rate.

[0021] During use, the azeotropic system formed by propylene glycol and water controls the release rate of the body fragrance, and the swelling property of the chitosan film adjusts the release of the base fragrance according to the environmental humidity change; moreover, the menthol microcrystals form a sustained-release dissolution layer on the surface of the fiber rod, continuously providing a cooling sensation stimulation, and forming an "excitation - soothing" olfactory balance with the woody base of the cedar seed oil, which can reduce olfactory fatigue.

[0022] In some embodiments of the present application, the above-mentioned fragrance includes top note, body note and base note; the top note includes grapefruit essential oil and spearmint essential oil; the body note includes rosemary CO2 extract and juniper essential oil; the base note includes cedar seed oil and menthol microcrystals.

[0023] In the present application, the top note uses grapefruit essential oil and spearmint essential oil. The grapefruit essential oil has a fresh citrus tone, which can quickly awaken the nerves, and the spearmint essential oil has a cooling sensation that penetrates and enhances the oxygen supply to the brain; both have high volatility and play an immediate stimulating and refreshing effect. The body note uses rosemary CO2 extract and juniper essential oil. Among them, the rosemary CO2 extract contains a high concentration of cineole, which enhances the synaptic activity of memory, and the juniper essential oil has a woody citrus tone, which balances anxiety. Both are medium volatile and improve the continuous concentration of the aromatherapy volatilization. The base note uses cedar seed oil and menthol microcrystals. Among them, the cedar seed oil contains natural sesquiterpenes, which stabilize nerve conduction, and the menthol microcrystals slowly release the drying factor, continuously stimulating the trigeminal nerve; both are low volatile and enhance the long-term soothing effect of the aromatherapy.

[0024] From the perspective of traditional Chinese medicine theory, the spearmint in the top note is cool in nature, pungent in taste, and belongs to the lung and liver meridians. The menthol it contains can stimulate the various orifices of the head and face. Inhaled through the mouth and nose, it can quickly "open the orifices", excite the central nervous system, and play a role in waking up the mind; the grapefruit essential oil has a fresh smell, and its pungent fragrance helps to disperse the stagnant qi in the upper jiao, promote the rise of clear yang, quickly relieve mental fatigue, and the grapefruit essential oil that volatilizes first and the spearmint essential oil "pungent fragrance running through" make people wake up and open the orifices. The rosemary in the body note is warm in nature, pungent in taste, enters the liver and spleen meridians, can promote qi and activate blood circulation, open the orifices, improve blood supply to the brain, and enhance concentration; the juniper essential oil is pungent in taste, warm in nature, and belongs to the kidney and bladder meridians, which can warm and dredge the yang qi in the lower jiao, and drive the spirit to vibrate with the movement of qi. The two work together to regulate qi and invigorate the spleen, and harmonize the qi of the whole body, maintaining the sustainability of refreshing. The cedar seed oil in the base note is warm in nature, sweet in taste, and enters the kidney meridian, which can strengthen the kidney and consolidate the foundation, fundamentally supplement the vital energy of the human body, and provide a material basis for refreshing; although the menthol microcrystals are cool in nature, when used in an appropriate amount and combined with the cedar seed oil, they can not only continuously stimulate the nerves to maintain wakefulness, but also avoid damaging the vital energy due to cold, forming a situation of "yin and yang assisting each other" and achieving the effect of "expelling pathogens without damaging the vital energy".

[0025] From the perspective of compatibility, the top note serves as the monarch drug, providing a rapid onset of action; the middle note serves as the minister drug, assisting and enhancing the efficacy; the base note serves as the assistant and guiding drug, harmonizing the medicinal properties and prolonging the duration of action. For example, microcrystalline menthol acts as the assistant and guiding drug, not only assisting the top note components to continuously stimulate the nerves but also restricting the warm nature of cedar seed oil, making the refreshing effect of the entire aromatherapy stable and lasting, and avoiding the "depletion of vital energy" caused by the drastic medicinal effect. The aromatherapy of this application forms a multi-sensory synergistic effect through olfactory stimulation and the cool tactile stimulation brought by microcrystalline menthol, conforming to the health concept of "nourishing both the body and the spirit" in traditional Chinese medicine. Olfactorily, the pungent fragrance enters the nose and reaches the brain, directly regulating the mind; tactilely, the cool sensation stimulates the body's meridians, guiding qi and blood upward, and stimulating the body's yang qi. The two work together to improve the mental state of the human body as a whole, achieving the refreshing effect of "regulating the inside and nourishing the outside, and vibrating both the body and the mind".

[0026] In some embodiments of this application, the above-mentioned fragrance includes: 0.05 - 0.1 part of grapefruit essential oil, 0.04 - 0.08 part of spearmint essential oil, 0.3 - 0.8 part of rosemary CO2 extract, 0.02 - 0.05 part of juniper essential oil, 0.2 - 0.4 part of cedar seed oil, and 0.8 - 1.2 parts of microcrystalline menthol.

[0027] In some embodiments of this application, the pore diameter of the above-mentioned mesoporous silica nanoparticles is 5 - 10 nm, which improves the encapsulation rate of the essential oil.

[0028] In some embodiments of this application, the above-mentioned aromatherapy raw materials further include phenoxy-1,3-butanediol and citric acid. The addition amount of phenoxy-1,3-butanediol is 0.5 part by weight, which is a mild preservative and can extend the shelf life of the product. The concentration of the citric acid solution is 0.1 moL / L, which is used to adjust the pH value of the final aromatherapy.

[0029] The modified cyclodextrin used in this application is prepared by the following method:

[0030] First, β-cyclodextrin is alkalized with a sodium hydroxide solution (at 30 - 40 °C for 0.5 - 1 h), then the system temperature is lowered to 25 °C, and propylene oxide is added dropwise (the molar ratio of propylene oxide to β-cyclodextrin is 5:1). The temperature is raised to 55 °C and stirred for 8 - 24 h. During this process, propylene oxide undergoes a ring-opening reaction with the sodium alkoxide on the alkalized β-cyclodextrin molecule, introducing hydroxypropyl groups into the β-cyclodextrin molecule. After the reaction, the pH is neutralized to 6 - 7 with a 1 - 2 mol / L hydrochloric acid solution, and finally, the modified cyclodextrin is obtained through concentration, alcohol precipitation, filtration, and washing.

[0031] A preparation method of a refreshing and sustained-release aromatherapy, comprising the following steps:

[0032] S1. Mix grapefruit essential oil, green mint essential oil with mesoporous silica nanoparticles, and perform ultrasonic oscillation to obtain Mixture I. This step is the loading of the top note by the nanocarrier mesoporous silica nanoparticles, enabling the top note essential oil molecules to embed into the mesoporous channels.

[0033] S2. Add rosemary CO2 extract and juniper essential oil to deionized water, and then slowly pour in modified cyclodextrin and stir to obtain Mixture II. The modified cyclodextrin is an aqueous solution with a concentration of 10%. This step forms a cyclodextrin-body note essential oil inclusion complex.

[0034] S3. Dissolve chitosan in an acetic acid solution to obtain a transparent viscous solution. Then add glycerol, propylene glycol, Mixture I and Mixture II, and after homogeneous dispersion, obtain Mixture III. This step enables the nanoscale carriers to be uniformly dispersed in the chitosan gel precursor, forming a hybrid matrix with a multi-layered slow-release structure. The cyclodextrin inclusion complex, as the slow-release core of the body note components, can control the release rate of the medium-volatility components after binding to the chitosan network in the gel matrix through changes in environmental humidity (such as the influence of air humidity on the swelling degree of the chitosan film), achieving the design goal of "continuous 24-hour release of body note components". This addition timing ensures the full compatibility of the nanoscale carriers with the gel matrix, laying the foundation for the subsequent "pore diffusion - membrane-controlled release" dual slow-release mechanism.

[0035] S4. Add 1,3-butanediol, cedar seed oil, and microcrystalline menthol to Mixture III, continuously stir to form a homogeneous system, and finally adjust the pH to 5.3 - 5.6. After standing, obtain the refreshing slow-release aromatherapy. Standing enables the chitosan molecular chains to form a hydrogen bond network with the hydroxyl groups on the surface of the mesoporous silica nanoparticles, strengthening the slow-release framework.

[0036] Fill the prepared liquid aromatherapy into a container, and use a porous fiber rod volatilizer (cotton and linen blended fiber with a diameter of 3 mm and a porosity of 65%). The bottle body is selected with a conical volatilization port (to control the evaporation area).

[0037] In some embodiments of the present application, the specific parameters of the ultrasonic oscillation in the above S1 step are: 40 kHz, power 200 W, time 25 - 40 min.

[0038] In some embodiments of the present application, the temperature of the deionized water in the above S2 step is 45 - 55 °C, and the stirring time is 2 - 3 h.

[0039] In some embodiments of the present application, the concentration of the acetic acid solution in the above S3 step is 0.1 moL / L; the speed of homogeneous dispersion is 8000 - 10000 rpm, and the time is 5 - 8 min.

[0040] In some embodiments of the present application, citric acid is used to adjust the pH in the above step S4; the continuous stirring speed is 200 - 300 rpm, and the time is 30 - 50 min; the standing time is 24 - 48 h.

[0041] The features and performance of the present application will be further described in detail below in conjunction with embodiments.

[0042] Example 1

[0043] A refreshing slow - release aromatherapy includes the following raw materials: 0.08 parts of grapefruit essential oil, 0.06 parts of spearmint essential oil, 0.5 parts of rosemary CO2 extract, 0.03 parts of juniper essential oil, 0.3 parts of cedar seed oil, 1 part of menthol microcrystals, 2.5 parts of mesoporous silica nanoparticles, 1.8 parts of modified cyclodextrin, 1.2 parts of chitosan, 5 parts of glycerol, 15 parts of 1,3 - butanediol, 10 parts of propylene glycol, and 60 parts of deionized water.

[0044] The preparation method is as follows:

[0045] S1. Mix grapefruit essential oil, spearmint essential oil with mesoporous silica nanoparticles, and perform ultrasonic oscillation for 30 min (40 KHz, 200 W) to obtain mixture I;

[0046] S2. Add rosemary CO2 extract and juniper essential oil to deionized water at 50 °C, and then slowly pour in modified cyclodextrin and stir to obtain mixture II;

[0047] S3. Dissolve chitosan in 0.1 M acetic acid solution to form a transparent viscous solution, then add glycerol, propylene glycol, mixture I and mixture II, and process with a high - speed homogenizer for 5 min (10000 rpm). After uniform dispersion, obtain mixture III;

[0048] S4. Add 1,3 - butanediol, cedar seed oil, and menthol microcrystals to mixture III, continuously stir to form a homogeneous system, and finally add citric acid to adjust the pH to 5.5. After standing for 24 h, obtain the refreshing slow - release aromatherapy of this example.

[0049] Example 2

[0050] A refreshing slow - release aromatherapy includes the following raw materials: 0.06 parts of grapefruit essential oil, 0.07 parts of spearmint essential oil, 0.6 parts of rosemary CO2 extract, 0.05 parts of juniper essential oil, 0.25 parts of cedar seed oil, 1.1 parts of menthol microcrystals, 2.6 parts of mesoporous silica nanoparticles, 1.2 parts of modified cyclodextrin, 1.5 parts of chitosan, 6.5 parts of glycerol, 12 parts of 1,3 - butanediol, 12 parts of propylene glycol, and 65 parts of deionized water.

[0051] The preparation method is as follows:

[0052] S1. Mix grapefruit essential oil, green mint essential oil and mesoporous silica nanoparticles, and ultrasonically oscillate for 35 min (40 KHz, 200 W) to obtain Mixture I;

[0053] S2. Add rosemary CO2 extract and juniper essential oil to deionized water at 50 °C, and then slowly pour in modified cyclodextrin and stir to obtain Mixture II;

[0054] S3. Dissolve chitosan in 0.1 M acetic acid solution to form a transparent viscous solution, then add glycerol, propylene glycol, Mixture I and Mixture II, and process with a high-speed homogenizer for 5 min (10,000 rpm). After uniform dispersion, obtain Mixture III;

[0055] S4. Add 1,3-butanediol, cedar seed oil and menthol microcrystals to Mixture III, continuously stir to form a homogeneous system, and finally add citric acid to adjust the pH to 5.6. Let it stand for 24 h to obtain the refreshing slow-release aromatherapy of this example.

[0056] Example 3

[0057] A refreshing slow-release aromatherapy, comprising the following raw materials: 0.1 part of grapefruit essential oil, 0.04 part of green mint essential oil, 0.4 part of rosemary CO2 extract, 0.02 part of juniper essential oil, 0.4 part of cedar seed oil, 1.1 parts of menthol microcrystals, 2.6 parts of mesoporous silica nanoparticles, 1.8 parts of modified cyclodextrin, 1.1 parts of chitosan, 6.5 parts of glycerol, 15 parts of 1,3-butanediol, 16 parts of propylene glycol and 70 parts of deionized water.

[0058] The preparation method is as follows:

[0059] S1. Mix grapefruit essential oil, green mint essential oil and mesoporous silica nanoparticles, and ultrasonically oscillate for 40 min (40 KHz, 200 W) to obtain Mixture I;

[0060] S2. Add rosemary CO2 extract and juniper essential oil to deionized water at 50 °C, and then slowly pour in modified cyclodextrin and stir to obtain Mixture II;

[0061] S3. Dissolve chitosan in 0.1 M acetic acid solution to form a transparent viscous solution, then add glycerol, propylene glycol, Mixture I and Mixture II, and process with a high-speed homogenizer for 5 min (10,000 rpm). After uniform dispersion, obtain Mixture III;

[0062] S4. Add 1,3-butanediol, cedar seed oil and menthol microcrystals to Mixture III, continuously stir to form a homogeneous system, and finally add citric acid to adjust the pH to 5.6. Let it stand for 36 h to obtain the refreshing slow-release aromatherapy of this example.

[0063] Example 4

[0064] A refreshing sustained-release aromatherapy, comprising the following raw materials: 0.05 parts of grapefruit essential oil, 0.04 parts of peppermint essential oil, 0.6 parts of rosemary CO2 extract, 0.03 parts of juniper essential oil, 0.4 parts of cedar seed oil, 1.1 parts of menthol microcrystals, 2.6 parts of mesoporous silica nanoparticles, 1.8 parts of modified cyclodextrin, 1.1 parts of chitosan, 7 parts of glycerol, 18 parts of 1,3-butanediol, 12 parts of propylene glycol, and 70 parts of deionized water.

[0065] The preparation method is as follows:

[0066] S1. Mix the grapefruit essential oil, peppermint essential oil with the mesoporous silica nanoparticles, and ultrasonically oscillate for 40 min (40 KHz, 200 W) to obtain mixture I;

[0067] S2. Add the rosemary CO2 extract and juniper essential oil to deionized water at 50 °C, and then slowly pour in the modified cyclodextrin and stir to obtain mixture II;

[0068] S3. Dissolve chitosan in a 0.1 M acetic acid solution to form a transparent viscous solution, then add glycerol, propylene glycol, mixture I and mixture II, and process with a high-speed homogenizer for 5 min (10,000 rpm). After uniform dispersion, obtain mixture III;

[0069] S4. Add 1,3-butanediol, cedar seed oil, and menthol microcrystals to mixture III, continuously stir to form a homogeneous system, and finally add citric acid to adjust the pH to 5.6. Let stand for 48 h to obtain the refreshing sustained-release aromatherapy of this example.

[0070] Example 5

[0071] A refreshing sustained-release aromatherapy, comprising the following raw materials: 0.09 parts of grapefruit essential oil, 0.04 parts of peppermint essential oil, 0.6 parts of rosemary CO2 extract, 0.04 parts of juniper essential oil, 0.3 parts of cedar seed oil, 1 part of menthol microcrystals, 2.8 parts of mesoporous silica nanoparticles, 1.4 parts of modified cyclodextrin, 1.2 parts of chitosan, 7 parts of glycerol, 14 parts of 1,3-butanediol, 13 parts of propylene glycol, and 65 parts of deionized water.

[0072] The preparation method is as follows:

[0073] S1. Mix the grapefruit essential oil, peppermint essential oil with the mesoporous silica nanoparticles, and ultrasonically oscillate for 25 min (40 KHz, 200 W) to obtain mixture I;

[0074] S2. Add the rosemary CO2 extract and juniper essential oil to deionized water at 50 °C, and then slowly pour in the modified cyclodextrin and stir to obtain mixture II;

[0075] S3. Dissolve chitosan in 0.1 M acetic acid solution to form a transparent viscous solution, then add glycerol, propylene glycol, mixture I and mixture II, and process with a high-speed homogenizer for 5 min (10,000 rpm). After uniform dispersion, mixture III is obtained.

[0076] S4. Add 1,3-butanediol, cedar seed oil, and microcrystalline menthol to mixture III, continuously stir to form a homogeneous system, and finally add citric acid to adjust the pH to 5.6. After standing for 40 h, the refreshing sustained-release aromatherapy of this example is obtained.

[0077] After testing, it is found that: in a constant temperature environment of 25 °C, the aromatherapy prepared in this application releases 20% of the top note components in the first 4 h, continuously releases 60% of the middle note components from 4 to 24 h, and slowly releases the base note components after 24 h. The total effective time can reach 20 - 30 days.

[0078] In the R & D stage, the applicant set up control experiments based on the solution of this application. Among them, in control experiment 1, mesoporous silica nanoparticles and modified cyclodextrin were not added, and its total effective time was within 15 days; in control experiment 2, each raw material was directly mixed, and the total effective time of the aromatherapy was 15 - 18 days. The above comparative experiments show that the "nanochannel adsorption - intelligent gel film control - volatile gradient regulation" of this application does have a sustained-release effect.

[0079] The embodiments described above are some, but not all, of the embodiments of this application. The detailed description of the embodiments of this application is not intended to limit the scope of this application claimed, but merely represents selected embodiments of this application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in this application without creative efforts fall within the scope of protection of this application.

Claims

1. A refreshing slow-release aromatherapy, characterized in that, In parts by weight, the aromatherapy includes the following raw materials: 1.5 - 2.5 parts of fragrance, 1.5 - 3 parts of mesoporous silica nanoparticles, 1.2 - 2 parts of modified cyclodextrin, 1 - 1.5 parts of chitosan, 3 - 8 parts of glycerol, 12 - 18 parts of 1,3 - butanediol, 8 - 15 parts of propylene glycol, and 55 - 75 parts of deionized water.

2. The refreshing slow-release aromatherapy according to claim 1, characterized in that, The fragrance includes top note, middle note, and base note; the top note includes grapefruit essential oil and spearmint essential oil; the middle note includes rosemary CO2 extract and juniper berry essential oil; the base note includes cedar seed oil and menthol microcrystals.

3. The refreshing sustained-release aromatherapy according to claim 2, wherein In parts by weight, the fragrance includes: 0.05 - 0.1 part of grapefruit essential oil, 0.04 - 0.08 part of spearmint essential oil, 0.3 - 0.8 part of rosemary CO2 extract, 0.02 - 0.05 part of juniper berry essential oil, 0.2 - 0.4 part of cedar seed oil, and 0.8 - 1.2 parts of menthol microcrystals.

4. The refreshing slow-release aromatherapy according to claim 1, characterized in that, The pore diameter of the mesoporous silica nanoparticles is 5 - 10 nm.

5. A refreshing slow-release aromatherapy according to any one of claims 1-4, characterized in that, The aromatherapy raw materials also include phenoxy 1,3 - butanediol and citric acid.

6. A preparation method of the refreshing slow-release aromatherapy according to any one of claims 1-5, characterized in that, It includes the following steps: S1. Mix grapefruit essential oil, spearmint essential oil with mesoporous silica nanoparticles, and perform ultrasonic oscillation to obtain mixture I; S2. Add rosemary CO2 extract and juniper berry essential oil to deionized water, and then slowly pour in modified cyclodextrin, and stir to obtain mixture II; S3. Dissolve chitosan in acetic acid solution, then add glycerol, propylene glycol, mixture I and mixture II, and perform homogeneous dispersion to obtain mixture III; S4. Add 1,3 - butanediol, cedar seed oil, and menthol microcrystals to mixture III, continuously stir to form a homogeneous system, and finally adjust the pH to 5.3 - 5.6, and let it stand to obtain the refreshing slow - release aromatherapy.

7. The preparation method of the refreshing sustained-release aromatherapy according to claim 6, characterized in that, The specific parameters of the ultrasonic oscillation in step S1 are: 40 kHz, power 200 W, time 25 - 40 min.

8. The preparation method of the refreshing slow-release aromatherapy according to claim 6, characterized in that, The temperature of the deionized water in step S2 is 45 - 55 °C, and the stirring time is 2 - 3 h.

9. The preparation method of the refreshing slow-release aromatherapy according to claim 6, characterized in that, The concentration of the acetic acid solution in step S3 is 0.1 moL / L; the speed of homogeneous dispersion is 8000 - 10000 rpm, and the time is 5 - 8 min.

10. The preparation method of the refreshing sustained-release aromatherapy according to claim 6, characterized in that, In step S4, citric acid is used to adjust the pH; the speed of continuous stirring is 200 - 300 rpm, and the time is 30 - 50 min; the standing time is 24 - 48 h.