A renewable cycle tourniquet and a preparation method thereof

Abstract

The application relates to a renewable and recyclable tourniquet and a preparation method thereof, and belongs to the technical field of tourniquet preparation. The tourniquet comprises the following raw materials in parts by weight: 70-95 parts of PBAT, 15-35 parts of a bio-based toughening agent, 10-20 parts of polyethylene, 5-10 parts of a modified inorganic filler, 1-3 parts of an antioxidant and 1-3 parts of a lubricant; the bio-based toughening agent is made from bio-based dibasic acid and bio-based trihydric alcohol through hyperbranched reaction. The bio-based toughening base, polyethylene and modified inorganic filler are introduced, the toughness of the PBAT base material is improved, the elastic performance of the obtained composite material is improved, and the obtained tourniquet meets the use requirements during hemostasis.

Description

Technical Field

[0001] This invention belongs to the field of tourniquet preparation technology, specifically, it relates to a regenerative and recyclable tourniquet and its preparation method. Background Technology

[0002] The tourniquet is made of medical-grade polymer material, is long and flat, and highly elastic. It is suitable for single-use use in medical institutions for routine treatment and rescue procedures such as intravenous infusion, blood drawing, and blood transfusion, or for emergency hemostasis of limb bleeding or bleeding from snake and insect bites in the wild.

[0003] Currently, the most common tourniquets on the market are rubber tourniquets. As rubber tourniquets are discarded, they become medical waste rubber. Rubber is difficult to degrade, ultimately leading to the problem of difficult disposal of medical waste rubber. Therefore, developing a recyclable tourniquet and its preparation method could solve the current problem of difficult waste tourniquet disposal. Summary of the Invention

[0004] To address the above problems, the present invention aims to provide a regenerable tourniquet and a method for preparing the same.

[0005] The first objective of this invention can be achieved through the following technical solution:

[0006] A regenerable tourniquet comprises the following raw materials in parts by weight: 70-95 parts PBAT (PBAT is the abbreviation of Poly(butylene adipate-co-terephthalate)), 15-35 parts bio-based toughening agent, 10-20 parts polyethylene, 5-10 parts modified inorganic filler, 1-3 parts antioxidant, and 1-3 parts lubricant.

[0007] The bio-based toughening agent is made from bio-based dicarboxylic acid and bio-based triol through a hyperbranching reaction.

[0008] Furthermore, the bio-based dicarboxylic acid is obtained by hydrosilylation reaction of 10-undecenoic acid and dihydro-terminated siloxane in a molar ratio of 2-3:1.

[0009] This invention uses bio-based dicarboxylic acids and bio-based triols as reaction substrates, and obtains hyperbranched polyesters through a hyperbranching reaction. These hyperbranched polyesters contain long alkyl chains (derived from castor oil derivative 10-undecenoic acid), siloxane chains, phenyl groups, and ester groups, with the long alkyl and siloxane chains serving as end-capping chains. Therefore, they can be used as toughening agents.

[0010] Further, the dihydrogen-terminated siloxane is one or a mixture of two of 1,1,3,3,5,5-hexamethyltrisiloxane and 1,1,5,5-tetramethyl-3,3-diphenyltrisiloxane in any ratio.

[0011] Furthermore, the hydrosilylation reaction is carried out in a first solvent and a first catalyst; the reaction temperature of the hydrosilylation reaction is 90-100℃, and the reaction time is 4-12h.

[0012] Furthermore, the first solvent is one of tetrahydrofuran, chloroform, benzene, and toluene; the first catalyst is one of platinum-based catalysts.

[0013] Furthermore, the bio-based triol is one or a mixture of two of resveratrol and dihydroresveratrol in any ratio.

[0014] The molecular structure of resveratrol is shown below.

[0015]

[0016] The molecular structure of the dihydroresveratrol is shown below.

[0017]

[0018] Furthermore, the molar ratio of the bio-based dicarboxylic acid to the bio-based triol is 3.5-4:2.

[0019] Furthermore, the hyperbranching reaction occurs in a second solvent and a second catalyst; the reaction temperature of the hyperbranching reaction is 90-130℃, and the reaction time is 6-12h.

[0020] Furthermore, the second solvent is one of chloroform, carbon tetrachloride, toluene, n-hexane, and cyclohexane; the second catalyst is one of concentrated sulfuric acid and p-toluenesulfonic acid.

[0021] Furthermore, the modified inorganic filler is an inorganic filler modified with a silane coupling agent. The method of modifying the inorganic filler with the silane coupling agent is common knowledge in this technical field, and will not be described in detail here. The silane coupling agent is one of the silane coupling agents well known in this technical field.

[0022] Furthermore, the inorganic filler is one of nano-silica or calcium carbonate whiskers.

[0023] The oxidizing agent and lubricant are well known in the art, and the present invention does not impose any particular limitation.

[0024] Furthermore, the second objective of this invention can be achieved through the following technical solution:

[0025] A method for preparing a regenerable and recyclable tourniquet, comprising:

[0026] After premixing PBAT, bio-based toughening agent, polyethylene, modified inorganic filler, antioxidant and lubricant, the mixture is melt-extruded, granulated and molded to obtain a tourniquet.

[0027] Furthermore, the melt extrusion temperature is 190-240℃.

[0028] The beneficial effects of this invention are:

[0029] The regenerative tourniquet and its preparation method provided by the present invention use PBAT as the base material, introduce polyethylene and modified inorganic fillers as elastic reinforcing fillers, and introduce bio-based toughening groups to improve the blending performance of polyethylene and modified inorganic fillers with PBAT, especially to improve the compatibility of polyethylene and PBAT, thereby improving the melt processing performance of the two blends.

[0030] This invention improves the toughness of PBAT-based materials and enhances the elastic properties of the resulting composite material by introducing bio-based toughening agents, polyethylene, and modified inorganic fillers. This allows the resulting tourniquet to meet the requirements for hemostasis. Furthermore, the bio-based toughening agent is made from the hyperbranching reaction (esterification reaction) of bio-based dicarboxylic acid and bio-based triol. Both the bio-based toughening agent and PBAT can recover the corresponding acid and alcohol monomers through ester decomposition reactions. In addition, during the ester decomposition reaction of the bio-based toughening agent and PBAT, polyethylene and inorganic fillers can also be recovered. Therefore, the hemostatic agent of this invention is recyclable and regenerable. Detailed Implementation

[0031] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0032] Example 1

[0033] Preparation of bio-based toughening agents:

[0034] A1. Mix 0.22 mol 10-undecenoic acid, 0.2 mol 1,1,5,5-tetramethyl-3,3-diphenyltrisiloxane and 100 mL benzene evenly, add 10 g platinum catalyst (carbon-supported platinum), heat to 90 °C, stir for 12 h, rotary evaporate, wash, and dry to obtain bio-based dicarboxylic acid.

[0035] A2. Mix 0.35 mol of bio-based dicarboxylic acid, 0.2 mol of resveratrol, 4 g of p-toluenesulfonic acid and 150 mL of carbon tetrachloride evenly, heat to 100 °C, stir and react for 12 h, evaporate by rotary evaporation, wash and dry to obtain bio-based toughening agent.

[0036] Example 2

[0037] Preparation of bio-based toughening agents:

[0038] A1. Mix 0.3 mol 10-undecenoic acid, 0.2 mol 1,1,3,3,5,5-hexamethyltrisiloxane and 100 mL toluene evenly, add 13 g platinum catalyst (carbon-supported platinum), heat to 100 °C, stir for 4 h, rotary evaporate, wash, and dry to obtain bio-based dicarboxylic acid.

[0039] A2. Mix 0.4 mol of bio-based dicarboxylic acid, 0.2 mol of dihydroresveratrol, 5 g of p-toluenesulfonic acid and 150 mL of n-hexane evenly, heat to 130 °C, stir and react for 6 h, rotary evaporate, wash and dry to obtain bio-based toughening agent.

[0040] Example 3

[0041] Preparation of tourniquet:

[0042] Step 1: Prepare the following raw materials by weight: 95 parts PBAT, 15 parts bio-based toughening agent prepared in Example 2, 20 parts polyethylene, 10 parts modified inorganic filler (KH570 modified nano-silica), 3 parts antioxidant (antioxidant 1010), and 3 parts lubricant (polyethylene wax).

[0043] The second step involves premixing PBAT, bio-based toughening agent, polyethylene, modified inorganic filler, antioxidant, and lubricant, followed by melt extrusion, granulation, and molding to obtain a tourniquet; the melt extrusion temperature is 190-240℃.

[0044] Example 4

[0045] Preparation of tourniquet:

[0046] Step 1: Prepare the following raw materials by weight: 85 parts PBAT, 25 parts bio-based toughening agent prepared in Example 2, 15 parts polyethylene, 7 parts modified inorganic filler (KH570 modified nano silica), 2 parts antioxidant (antioxidant 1010), and 2 parts lubricant (polyethylene wax).

[0047] The second step involves premixing PBAT, bio-based toughening agent, polyethylene, modified inorganic filler, antioxidant, and lubricant, followed by melt extrusion, granulation, and molding to obtain a tourniquet; the melt extrusion temperature is 190-240℃.

[0048] Example 5

[0049] Preparation of tourniquet:

[0050] Step 1: Prepare the following raw materials by weight: 70 parts PBAT, 35 parts bio-based toughening agent prepared in Example 1, 10 parts polyethylene, 5 parts modified inorganic filler (KH570 modified nano silica), 1 part antioxidant (antioxidant 1010), and 1 part lubricant (polyethylene wax).

[0051] The second step involves premixing PBAT, bio-based toughening agent, polyethylene, modified inorganic filler, antioxidant, and lubricant, followed by melt extrusion, granulation, and molding to obtain a tourniquet; the melt extrusion temperature is 190-240℃.

[0052] Comparative Example 1

[0053] Preparation of tourniquet:

[0054] Compared to Example 3, the bio-based toughening agent in the raw materials was removed, but the rest were the same.

[0055] Comparative Example 2

[0056] Preparation of tourniquet:

[0057] Compared to Example 3, polyethylene was removed from the raw materials, but the rest were the same.

[0058] Comparative Example 3

[0059] Preparation of tourniquet:

[0060] Compared to Example 3, the inorganic filler in the raw materials was removed, but the rest were the same.

[0061] The granules obtained in Examples 3-5 and Comparative Examples 1-3 were prepared into samples and subjected to the following physical property tests. The test results are shown in Table 1.

[0062] Table 1

[0063] Serial Number Tensile strength Elongation at break Test Standards GB / T 1040 GB / T 1040 unit MPa ％ Example 3 23.1 328 Example 4 25.6 345 Example 5 16.8 362 Comparative Example 1 16.3 184 Comparative Example 2 20.7 236 Comparative Example 3 22.2 268

[0064] As can be seen from the data in Table 1, the tourniquet granules obtained in Examples 3-5 have good elastic properties.

[0065] In the description of this specification, the references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0066] The above description is merely an example and illustration of the present invention. Those skilled in the art can make various modifications or additions to the specific embodiments described, or use similar methods to replace them, as long as they do not deviate from the invention or exceed the scope defined in the claims, all of which should fall within the protection scope of the present invention.

Claims

1. A regenerative and reusable tourniquet, characterized in that, The raw materials include the following parts by weight: 70-95 parts PBAT, 15-35 parts bio-based toughening agent, 10-20 parts polyethylene, 5-10 parts modified inorganic filler, 1-3 parts antioxidant, and 1-3 parts lubricant. The bio-based toughening agent is prepared by hyperbranching of bio-based dicarboxylic acid and bio-based triol. The bio-based dicarboxylic acid is obtained by hydrosilylation reaction of 10-undecenoic acid and dihydroterminated siloxane in a molar ratio of 2-3:

1. The dihydrogen-terminated siloxane is one or a mixture of two of 1,1,3,3,5,5-hexamethyltrisiloxane and 1,1,5,5-tetramethyl-3,3-diphenyltrisiloxane in any ratio. The bio-based triol is one or a mixture of two of resveratrol and dihydroresveratrol in any ratio; The molar ratio of the bio-based dicarboxylic acid to the bio-based triol is 3.5-4:

2.

2. The regenerable tourniquet according to claim 1, characterized in that, The hydrosilylation reaction is carried out in a first solvent and a first catalyst; the reaction temperature of the hydrosilylation reaction is 90-100℃ and the reaction time is 4-12h.

3. The regenerable tourniquet according to claim 2, characterized in that, The first solvent is one of tetrahydrofuran, chloroform, benzene, and toluene; the first catalyst is one of platinum group catalysts.

4. The regenerable tourniquet according to claim 1, characterized in that, The hyperbranching reaction occurs in a second solvent and a second catalyst; the reaction temperature is 90-130℃ and the reaction time is 6-12h.

5. A regenerative and reusable tourniquet according to claim 4, characterized in that, The second solvent is one of chloroform, carbon tetrachloride, toluene, n-hexane, and cyclohexane; the second catalyst is one of concentrated sulfuric acid and p-toluenesulfonic acid.

6. The method for preparing a regenerable and recyclable tourniquet according to claim 1, characterized in that, include: After premixing PBAT, bio-based toughening agent, polyethylene, modified inorganic filler, antioxidant and lubricant, the mixture is melt-extruded, granulated and molded to obtain a tourniquet.

Images