Membrane ion active mesona chinensis bath concentrated solution

Abstract

Belonging to the technical field of traditional Chinese medicine bath, the invention provides an element ion active mesona chinensis bath concentrate, which is composed of a component A extract, a component B extract and a saffron crocus coating, wherein the component A comprises poria cocos, folium artemisiae argyi, lotus leaves, roses, motherwort, perilla leaves, radix angelicae, radix saposhnikoviae and fructus lycii, and the component B comprises radix puerariae, rhodiola rosea, ligusticum wallichii and caulis spatholobi. According to the invention, medicines with different compositions are specifically extracted, so that the yield of the extract is ensured, the activity of effective antibacterial components of traditional Chinese medicines can be improved, the prepared bubble bath concentrated solution has a good antibacterial effect, the effective components of saffron crocus are independently treated by shell powder and polyvinyl alcohol, the long-term coexistence of the effective components of saffron crocus and poria cocos is realized, and the preparation method is simple and convenient. The antibacterial effect of the prepared concentrated solution has relatively high long-term stability.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine bath, and specifically relates to a yuan-ion active fairy grass bath concentrate. Background Art

[0002] With the accelerating pace of life, bath, as a way of keeping in good health, can not only relieve fatigue, but also promote metabolism, protect skin and whiten skin, and is more and more favored by people.

[0003] Adding traditional Chinese medicine with special effects during the bath process can endow it with certain antibacterial and bactericidal effects, and enhance the human immunity while people relax. In the prior art, the traditional Chinese medicine bath liquid has received more and more attention due to its characteristics of convenient carrying and fast drug release speed. In the current technology, the traditional Chinese medicine bath liquid generally simply extracts the drug components uniformly. The drug components are in a liquid environment for a long time and are prone to react and deteriorate, resulting in the difficulty of maintaining the effective components of the drug for a long time and affecting the antibacterial effect.

[0004] Therefore, there is an urgent need for a bath concentrate that can maintain long-term stable antibacterial and bactericidal ability while regulating human health and realize the long-term storage of the traditional Chinese medicine bath liquid. Summary of the Invention

[0005] To solve the problems in the background art, the present invention provides a yuan-ion active fairy grass bath concentrate.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] The yuan-ion active fairy grass bath concentrate is composed of an A-component extract, a B-component extract and a saffron coating. The specific weight ratios of the raw materials used in the A-component extract and the B-component extract are as follows: the A component is 30-35 parts of Poria cocos, 18-22 parts of Artemisia argyi, 8-10 parts of lotus leaf, 2-5 parts of rose flower, 10-20 parts of Leonurus japonicus, 10-15 parts of Perilla frutescens, 3-5 parts of Angelica dahurica, 2.5-3.5 parts of Saposhnikovia divaricata and 1-2 parts of Lycium barbarum; the B component is 18-22 parts of Pueraria lobata, 20-30 parts of Rhodiola rosea, 5-7 parts of Ligusticum chuanxiong and 20-30 parts of Spatholobus suberectus.

[0008] The preparation process of the yuan-ion active fairy grass bath concentrate includes the following steps:

[0009] A1. Weigh each raw material of the A component according to parts by weight, dry and crush it, add 5-10 times the amount of ethanol solution, soak it at room temperature for 10-20 hours, carry out water bath reflux extraction 2 times at a temperature of 80-90 °C, combine the extraction solutions, and concentrate the extraction solutions to obtain the A-component extract;

[0010] A2. Weigh each raw material of component B by weight, dry and crush it, add 8 - 12 times the amount of deionized water to obtain a slurry. Add 1 - 2% of the strain activation solution to the slurry, ferment at 35 - 40 °C for 2 - 3 days to obtain a fermented material. Heat the fermented material to 95 - 100 °C, boil for 1 - 2 hours, filter, concentrate the filtrate to obtain the extract of component B.

[0011] A3. Mix the extract of component B with the extract of component A to obtain a mixed extract, then add 1.0 - 1.2% of saffron coating based on the mass of the mixed extract, stir evenly to obtain the original ionic active fairy grass bath concentrate.

[0012] Preferably, the preparation of the saffron coating includes the following steps:

[0013] S1. Add saffron to 8 - 12 times the amount of water of the medicinal materials by weight. Under closed conditions, heat to 95 - 100 °C, keep warm for extraction for 1 - 2 hours, filter to obtain filtrate A and medicinal residues. Add 8 - 12 times the amount of water to the medicinal residues, under closed conditions, heat to 95 - 100 °C again, keep warm for extraction for 1 - 2 hours, filter to obtain filtrate B and medicinal residues. Combine filtrate A and filtrate B to obtain the saffron extract.

[0014] S2. Add shell powder with a particle size range of 1000 - 1500 mesh to the saffron extract, and the mass of the shell powder is 1 - 1.5% of the mass of the saffron extract. Stir for 0.5 - 1 hour, heat to 35 - 40 °C, add 0.5 - 0.7% of polyvinyl alcohol based on the mass of the saffron extract, keep warm for 1 - 2 hours, concentrate under reduced pressure to a concentrated solution with a density of 1.12 - 1.15 g / ml, dry, and pass through a 200 - mesh sieve to obtain the saffron coating.

[0015] Preferably, in step A2, the preparation of the strain activation solution includes the following: Activate Bifidobacterium to a strain concentration of 1.5 - 2.8×10 7 CFU / mL to obtain the Bifidobacterium activation solution, activate Lactobacillus acidophilus to a strain concentration of 4.7 - 7.2×10 6 CFU / mL to obtain the Lactobacillus acidophilus activation solution, and mix the above two activation solutions according to a mass ratio of 1:1 to obtain the strain activation solution.

[0016] Preferably, in step A1, the concentration density of the extract of component A is 1.10 - 1.20 g / ml.

[0017] Preferably, in step A2, the concentration density of the extract of component B is 1.15 - 1.25 g / ml.

[0018] Preferably, in step A1, the volume fraction of the ethanol solution is 70 - 80%.

[0019] Preferably, in steps A1 and A2, the concentration process is vacuum concentration.

[0020] The present application has the following beneficial effects:

[0021] 1. The present invention provides a meta-ion active fairy grass bath concentrate. The extraction method used is different from the traditional unified extraction method. By specifically extracting drugs with different compositions, not only the yield of the extract is ensured, but also the activity of the effective antibacterial components of traditional Chinese medicine is improved. The effective components contained are derived from natural plants, are mild and have no toxic side effects, have a good antibacterial effect, and have good inhibitory effects on Staphylococcus aureus, Escherichia coli, and Candida albicans.

[0022] 2. The main active components of Poria cocos include triterpenoids, polysaccharide compounds, etc., and have effects such as anti-inflammatory and antivirus, enhancing immunity, etc. Saffron has the effects of promoting blood circulation, antibacterial and anti-inflammatory, and also has the effects of beauty and helping sleep. However, it has been found through research that Poria cocos and saffron have a strong antibacterial effect in the liquid phase environment in the short term, but the antibacterial effect is difficult to maintain for a long time, affecting the stability of the bactericidal efficacy. Shell powder is a surface porous material and also a natural beauty and skin care product, and at the same time has the effects of clearing heat and anti-inflammatory, antibacterial and anti-inflammatory, and massage. Through the adsorption of the effective components of saffron by shell powder and the coating of polyvinyl alcohol, not only the efficacy of saffron is ensured, but also the long-term coexistence of the effective components of saffron and Poria cocos is achieved, and finally the antibacterial effect of the prepared concentrate has high long-term stability. Specific embodiments

[0023] The following further elaborates on the present application with reference to embodiments.

[0024] The raw materials of the embodiments and comparative examples of the present application are all ordinary commercially available products unless otherwise specified.

[0025] Example 1

[0026] The meta-ion active fairy grass bath concentrate is composed of an A-component extract, a B-component extract, and a saffron coating. The specific weight ratios of the raw materials used in the A-component extract and the B-component extract are as follows: The A-component raw materials include 32 parts of Poria cocos, 20 parts of Artemisia argyi, 9 parts of lotus leaf, 3.5 parts of rose, 15 parts of motherwort, 12 parts of perilla leaf, 4 parts of angelica dahurica, 3 parts of ledebouriella seseloides, and 1.5 parts of wolfberry fruit. The B-component raw materials include 20 parts of kudzu root, 25 parts of rhodiola rosea, 6 parts of chuanxiong, and 25 parts of millettia reticulata.

[0027] The preparation process of the meta-ion active fairy grass bath concentrate includes the following steps:

[0028] A1. Weigh each raw material of component A by weight, dry it, crush it, sieve it through a 20-mesh sieve, add 8 times the volume of 75% ethanol solution, soak it at room temperature for 15 hours, reflux and extract it twice in a water bath at 85 °C for 2 hours each time. Combine the extraction solutions, concentrate the extraction solutions under reduced pressure until the density reaches 1.15 g / ml to obtain the extract of component A.

[0029] A2. Weigh each raw material of component B by weight, dry it, crush it, sieve it through a 20-mesh sieve, add 10 times the amount of deionized water to obtain a slurry. By mass, add 1.5% of the activated strain solution to the slurry, ferment it at 38 °C for 2 days to obtain a fermented material. Heat the fermented material to 95 °C and boil it for 2 hours, then filter. Concentrate the filtrate under reduced pressure until the density reaches 1.20 g / ml to obtain the extract of component B.

[0030] A3. At room temperature, mix the extract of component B with the extract of component A to obtain a mixed extract, then add 1.1% of the saffron coating material based on the mass of the mixed extract, and stir evenly to obtain the yuan ionic active fairy grass bath concentrated liquid.

[0031] In step A2, the preparation of the activated strain solution includes the following: Activate Bifidobacterium until the strain concentration reaches 2.1×10 7 CFU / mL to obtain the Bifidobacterium activated solution, activate Lactobacillus acidophilus until the strain concentration reaches 5.3×10 6 CFU / mL to obtain the Lactobacillus acidophilus activated solution. Mix the above two activated solutions in a mass ratio of 1:1 to obtain the activated strain solution.

[0032] The preparation of the saffron coating material includes the following steps:

[0033] S1. By weight, add saffron to 10 times the amount of water of the medicinal materials. Under closed conditions, heat it to 95 °C, keep it warm for extraction for 2 hours, filter to obtain filtrate A and medicinal residues. Add 10 times the amount of water based on the mass of the medicinal residues to the medicinal residues, under closed conditions, heat it to 95 °C again, keep it warm for extraction for 2 hours, filter to obtain filtrate B and medicinal residues. Combine filtrate A and filtrate B to obtain the saffron extraction solution.

[0034] S2. Add shell powder with a particle size range of 1000 meshes to the saffron extraction solution. The mass of the shell powder is 1.2% of the mass of the saffron extraction solution. Stir for 0.5 hours, heat it to 40 °C, add 0.6% of polyvinyl alcohol based on the mass of the saffron extraction solution, keep it warm for 1 hour, concentrate it under reduced pressure to a concentrated solution with a density of 1.13 g / ml, dry it, and sieve it through a 200-mesh sieve to obtain the saffron coating material.

[0035] Example 2

[0036] The original ionic active fairy herb bath concentrate is composed of the extract of component A, the extract of component B and the saffron coating. The specific weight ratios of the raw materials used in the extract of component A and the extract of component B are as follows: The raw materials of component A include 30 parts of Poria cocos, 18 parts of Artemisia argyi, 8 parts of lotus leaf, 2 parts of rose, 10 parts of Leonurus japonicus, 10 parts of Perilla frutescens, 3 parts of Angelica dahurica, 2.5 parts of Saposhnikovia divaricata and 1 part of Lycium barbarum. The raw materials of component B include 18 parts of Pueraria lobata, 20 parts of Rhodiola rosea, 5 parts of Ligusticum chuanxiong and 20 parts of Spatholobus suberectus.

[0037] The original ionic active fairy herb bath concentrate, its preparation process includes the following steps:

[0038] A1. By weight, weigh each raw material of component A, dry and crush it, pass through a 20-mesh sieve, add 5 times the volume of 70% ethanol solution, soak at room temperature for 10 hours, reflux extract in a water bath at 80 °C for 2 times, 3 hours each time, combine the extracts, and concentrate the extracts under reduced pressure until the density is 1.10 g / ml to obtain the extract of component A;

[0039] A2. By weight, weigh each raw material of component B, dry and crush it, pass through a 20-mesh sieve, add 8 times the amount of deionized water to obtain a slurry. By mass, add 1% of the strain activation solution to the slurry, ferment at 35 °C for 3 days to obtain a fermented material, heat the fermented material to 100 °C, boil for 1 hour, filter, and concentrate the filtrate under reduced pressure until the density is 1.15 g / ml to obtain the extract of component B;

[0040] A3. At room temperature, mix the extract of component B and the extract of component A to obtain a mixed extract, then add 1.0% of the saffron coating based on the mass of the mixed extract, and stir evenly to obtain the original ionic active fairy herb bath concentrate.

[0041] In step A2, the preparation of the strain activation solution includes the following content: Activate Bifidobacterium to a strain concentration of 2.1×10 7 CFU / mL to obtain the Bifidobacterium activation solution, activate Lactobacillus acidophilus to a strain concentration of 5.3×10 6 CFU / mL to obtain the Lactobacillus acidophilus activation solution, and mix the above two activation solutions according to a mass ratio of 1:1 to obtain the strain activation solution.

[0042] The preparation of the saffron coating includes the following steps:

[0043] S1. By weight, add saffron to 8 times the amount of water of the medicinal materials, heat to 95 °C under closed conditions, keep warm and extract for 2 hours, filter to obtain filtrate A and medicinal residues, add 12 times the amount of water of the medicinal residues to the medicinal residues, heat to 95 °C again under closed conditions, keep warm and extract for 2 hours, filter to obtain filtrate B and medicinal residues, and combine filtrate A and filtrate B to obtain the saffron extract;

[0044] S2. Add shell powder with a particle size range of 1000 mesh to the saffron extract. The mass of the shell powder is 1% of the mass of the saffron extract. Stir for 0.5 h, heat to 35 °C, add polyvinyl alcohol accounting for 0.5% of the mass of the saffron extract, keep warm for 2 h, concentrate under reduced pressure to a concentrated solution with a density of 1.12 g / ml, dry, and pass through a 200-mesh sieve to obtain the saffron coating.

[0045] Example 3

[0046] The yuan-ion active fairy grass bath concentrated solution is composed of the extract of component A, the extract of component B, and the saffron coating. The specific weight ratios of the raw materials used in the extract of component A and the extract of component B are as follows: The raw materials of component A include 35 parts of Poria cocos, 22 parts of Artemisia argyi, 8 parts of lotus leaf, 2 parts of rose, 20 parts of Leonurus japonicus, 15 parts of Perilla frutescens, 5 parts of Angelica dahurica, 2.5 parts of Saposhnikovia divaricata, and 1 part of Lycium barbarum. The raw materials of component B include 18 parts of Pueraria lobata, 20 parts of Rhodiola rosea, 7 parts of Ligusticum chuanxiong, and 30 parts of Spatholobus suberectus.

[0047] The preparation process of the yuan-ion active fairy grass bath concentrated solution includes the following steps:

[0048] A1. Weigh each raw material of component A according to parts by weight, dry and crush it, pass through a 20-mesh sieve, add 10 times the amount of an ethanol solution with a volume fraction of 80%, soak at room temperature for 20 hours, carry out water bath reflux extraction twice at 90 °C for 1 h each time, combine the extraction solutions, and concentrate the extraction solutions under reduced pressure to a density of 1.20 g / ml to obtain the extract of component A;

[0049] A2. Weigh each raw material of component B according to parts by weight, dry and crush it, pass through a 20-mesh sieve, add 12 times the amount of deionized water to obtain a slurry. According to parts by mass, add 2% of the strain activation solution to the slurry, ferment at 40 °C for 2 d to obtain a fermented material, heat the fermented material to 100 °C, boil for 1 h, filter, and concentrate the filtrate under reduced pressure to a density of 1.15 g / ml to obtain the extract of component B;

[0050] A3. At room temperature, mix the extract of component B with the extract of component A to obtain a mixed extract, and then add the saffron coating accounting for 1.0% of the mass of the mixed extract, stir evenly to obtain the yuan-ion active fairy grass bath concentrated solution.

[0051] In step A2, the preparation of the strain activation solution includes the following content: Activate Bifidobacterium to a strain concentration of 2.1×10 7 CFU / mL to obtain the Bifidobacterium activation solution, activate Lactobacillus acidophilus to a strain concentration of 5.3×10 6 CFU / mL to obtain the Lactobacillus acidophilus activation solution, and mix the above two activation solutions according to a mass ratio of 1:1 to obtain the strain activation solution.

[0052] The preparation of the saffron coating includes the following steps:

[0053] S1. By weight, add saffron to 10 times the amount of water of the medicinal materials. Under closed conditions, heat to 96 °C, keep warm and extract for 2 h, filter to obtain filtrate A and medicinal residues. Add 10 times the amount of water of the mass of the medicinal residues to the medicinal residues. Under closed conditions, heat to 96 °C again, keep warm and extract for 2 h, filter to obtain filtrate B and medicinal residues. Combine filtrate A and filtrate B to obtain the saffron extract.

[0054] S2. Add shell powder with a particle size range of 1500 mesh to the saffron extract. The mass of the shell powder is 1.5% of the mass of the saffron extract. Stir for 1 h, heat to 35 °C, add 0.5% of polyvinyl alcohol based on the mass of the saffron extract, keep warm for 2 h, concentrate under reduced pressure to a concentrated solution with a density of 1.12 g / ml, dry, and pass through a 200-mesh sieve to obtain the saffron coating.

[0055] Example 4

[0056] The yuan-ion active fairy grass bath concentrated liquid is composed of the extract of component A, the extract of component B and the saffron coating. The specific weight ratios of the raw materials used in the extract of component A and the extract of component B are as follows: The raw materials of component A include 30 parts of Poria cocos, 22 parts of Artemisia argyi, 10 parts of lotus leaf, 2 parts of rose, 20 parts of Leonurus japonicus, 10 parts of Perilla leaf, 3 parts of Angelica dahurica, 2.5 parts of Saposhnikovia divaricata and 1 part of Lycium barbarum. The raw materials of component B include 22 parts of Pueraria lobata, 20 parts of Rhodiola rosea, 5 parts of Ligusticum chuanxiong and 20 parts of Spatholobus suberectus.

[0057] The preparation process of the yuan-ion active fairy grass bath concentrated liquid includes the following steps:

[0058] A1. By weight, weigh each raw material of component A, dry and crush, pass through a 20-mesh sieve, add 5 times the amount of ethanol solution with a volume fraction of 70%, soak at room temperature for 20 hours, reflux and extract 2 times in a water bath at 90 °C for 1 h each time, combine the extracts, and concentrate the extracts under reduced pressure to a density of 1.10 g / ml to obtain the extract of component A.

[0059] A2. By weight, weigh each raw material of component B, dry and crush, pass through a 20-mesh sieve, add 8 times the amount of deionized water to obtain a slurry. By mass, add 2% of the strain activation solution to the slurry, ferment at 35 °C for 3 d to obtain a fermented material, heat the fermented material to 100 °C, boil for 1 h, filter, and concentrate the filtrate under reduced pressure to a density of 1.15 g / ml to obtain the extract of component B.

[0060] A3. At room temperature, mix the extract of component B with the extract of component A to obtain a mixed extract, and then add saffron coating accounting for 1.1% of the mass of the mixed extract, and stir evenly to obtain the meta-ion active fairy grass bath concentrate.

[0061] In step A2, the preparation of the strain activation liquid includes the following: Activate the Bifidobacterium until the strain concentration reaches 2.1×10 7 CFU / mL to obtain the Bifidobacterium activation liquid, activate the Lactobacillus acidophilus strain until the strain concentration reaches 5.3×10 6 CFU / mL to obtain the Lactobacillus acidophilus activation liquid, and mix the above two activation liquids according to a mass ratio of 1:1 to obtain the strain activation liquid.

[0062] The preparation of the saffron coating includes the following steps:

[0063] S1. By weight, add saffron to 8 times the amount of water of the medicinal materials, heat to 98°C under closed conditions, keep warm for extraction for 1.5 h, filter to obtain filtrate A and medicinal residues, add 10 times the mass of the medicinal residues of water to the medicinal residues, heat to 98°C again under closed conditions, keep warm for extraction for 1.5 h, filter to obtain filtrate B and medicinal residues, and combine filtrate A and filtrate B to obtain the saffron extract;

[0064] S2. Add shell powder with a particle size range of 1200 mesh to the saffron extract, and the mass of the shell powder is 1% of the mass of the saffron extract. Stir for 1 h, heat to 40°C, add polyvinyl alcohol accounting for 0.6% of the mass of the saffron extract, keep warm for 1 h, concentrate under reduced pressure to a concentrate with a density of 1.14 g / ml, dry, and pass through a 200-mesh sieve to obtain the saffron coating.

[0065] Example 5

[0066] The meta-ion active fairy grass bath concentrate of the present invention is composed of the extract of component A, the extract of component B and the saffron coating. The specific weight ratios of the raw materials used in the extract of component A and the extract of component B are as follows: The raw materials of component A include 35 parts of Poria cocos, 18 parts of Artemisia argyi, 8 parts of lotus leaf, 4 parts of rose, 12 parts of Leonurus japonicus, 13 parts of Perilla leaf, 4 parts of Angelica dahurica, 3 parts of Saposhnikovia divaricata and 1 part of Lycium barbarum; the raw materials of component B include 22 parts of Pueraria lobata, 25 parts of Rhodiola rosea, 5 parts of Ligusticum chuanxiong and 30 parts of Spatholobus suberectus.

[0067] The preparation process of the meta-ion active fairy grass bath concentrate includes the following steps:

[0068] A1. Weigh each raw material of component A by weight, dry and crush it, pass it through a 20-mesh sieve, add 7 times the volume of 75% ethanol solution, soak it at room temperature for 10 hours, reflux and extract it twice in a water bath at 85°C for 2 hours each time. Combine the extracts, concentrate the extracts under reduced pressure until the density reaches 1.15 g / ml to obtain the extract of component A;

[0069] A2. Weigh each raw material of component B by weight, dry and crush it, pass it through a 20-mesh sieve, add 8 times the amount of deionized water to obtain a slurry. By mass, add 1.5% of the strain activation solution to the slurry, ferment it at 40°C for 2 days to obtain a fermented material. Heat the fermented material to 95°C and boil it for 2 hours, filter it, concentrate the filtrate under reduced pressure until the density reaches 1.20 g / ml to obtain the extract of component B;

[0070] A3. At room temperature, mix the extract of component B and the extract of component A evenly to obtain a mixed extract, and then add 1.2% of the saffron coating material based on the mass of the mixed extract, stir evenly to obtain the original ion-active fairy grass bath concentrate.

[0071] In step A2, the preparation of the strain activation solution includes the following: Activate Bifidobacterium until the strain concentration reaches 2.1×10 7 CFU / mL to obtain the Bifidobacterium activation solution, activate Lactobacillus acidophilus until the strain concentration reaches 5.3×10 6 CFU / mL to obtain the Lactobacillus acidophilus activation solution, and mix the above two activation solutions in a mass ratio of 1:1 to obtain the strain activation solution.

[0072] The preparation of the saffron coating material includes the following steps:

[0073] S1. By weight, add saffron to 10 times the amount of water, heat it to 95°C under closed conditions, keep it warm and extract for 2 hours, filter it to obtain filtrate A and medicinal residues. Add 12 times the amount of water based on the mass of the medicinal residues to the medicinal residues, heat it to 95°C again under closed conditions, keep it warm and extract for 2 hours, filter it to obtain filtrate B and medicinal residues. Combine filtrate A and filtrate B to obtain the saffron extract;

[0074] S2. Add shell powder with a particle size range of 1000 mesh to the saffron extract, and the mass of the shell powder is 1.25% of the mass of the saffron extract. Stir for 1 hour, heat it to 40°C, add 0.6% of polyvinyl alcohol based on the mass of the saffron extract, keep it warm for 1 hour, concentrate it under reduced pressure to a concentrated solution with a density of 1.12 g / ml, dry it, and pass it through a 200-mesh sieve to obtain the saffron coating material.

[0075] Comparative Example 1

[0076] The difference between this comparative example and the example lies only in that for the Yuan-ion active fairy grass bath concentrate, in steps A1 and A2 of its preparation process, the raw materials of component A and component B are both extracted using an ethanol solution, specifically including the following steps:

[0077] A1. Weigh the raw materials of component A and component B by weight, dry and crush them, pass through a 20-mesh sieve, add 8 times the volume of 75% ethanol solution, soak at room temperature for 15 hours, reflux extract in a water bath at 85°C for 2 times, 2 hours each time, combine the extracts, and concentrate the extracts under reduced pressure until the density is 1.15 g / ml to obtain a mixed extract;

[0078] A2. At room temperature, add saffron coating accounting for 1.1% of the mass of the mixed extract to the mixed extract and stir evenly to obtain the Yuan-ion active fairy grass bath concentrate.

[0079] Comparative Example 2

[0080] The difference between this comparative example and the example lies only in that for the Yuan-ion active fairy grass bath concentrate, in steps A1 and A2 of its preparation process, the raw materials of component A and component B are both extracted using the biological fermentation method, specifically including the following steps:

[0081] A1. Weigh the raw materials of component A and component B by weight, dry and crush them, pass through a 20-mesh sieve, add 10 times the amount of deionized water to obtain a slurry. By mass, add 1.5% of the strain activation solution to the slurry, ferment at 38°C for 2 days to obtain a fermented material, heat the fermented material to 95°C, boil for 2 hours, filter, and concentrate the filtrate under reduced pressure until the density is 1.20 g / ml to obtain a mixed extract;

[0082] A2. At room temperature, add saffron coating accounting for 1.1% of the mass of the mixed extract to the mixed extract and stir evenly to obtain the Yuan-ion active fairy grass bath concentrate.

[0083] Comparative Example 3

[0084] The difference between this comparative example and the example lies only in that in the raw materials used for the extract of component A, Poria cocos is not added, specifically as follows:

[0085] The Yuan-ion active fairy grass bath concentrate of the present invention is composed of the extract of component A, the extract of component B, and saffron coating. The specific weight ratios of the raw materials used for the extract of component A and the extract of component B are as follows: The raw materials of component A include 32 parts of Poria cocos, 20 parts of Artemisia argyi, 9 parts of lotus leaf, 3.5 parts of rose flower, 15 parts of Leonurus japonicus, 12 parts of Perilla frutescens, 4 parts of Angelica dahurica, 3 parts of Saposhnikovia divaricata, and 1.5 parts of Lycium barbarum; the raw materials of component B include 20 parts of Pueraria lobata, 25 parts of Rhodiola rosea, 6 parts of Ligusticum chuanxiong, and 25 parts of Spatholobus suberectus.

[0086] Comparative Example 4

[0087] The difference between this comparative example and the example is only that in the preparation of the Yuan-ion active fairy grass bath concentrate, saffron coating is not added, specifically as follows:

[0088] The Yuan-ion active fairy grass bath concentrate, its preparation process includes the following steps:

[0089] A1. By weight, weigh each raw material of component A, dry and crush it, pass through a 20-mesh sieve, add 8 times the volume of 75% ethanol solution, soak at room temperature for 15 hours, reflux extract twice at 85 °C in a water bath for 2 hours each time, combine the extracts, and concentrate the extracts under reduced pressure until the density is 1.15 g / ml to obtain the extract of component A;

[0090] A2. By weight, weigh each raw material of component B, dry and crush it, pass through a 20-mesh sieve, add 10 times the amount of deionized water to obtain a slurry. By mass, add 1.5% of the strain activation solution to the slurry, ferment at 38 °C for 2 days to obtain a fermented material, heat the fermented material to 95 °C, boil for 2 hours, filter, and concentrate the filtrate under reduced pressure until the density is 1.20 g / ml to obtain the extract of component B;

[0091] A3. At room temperature, mix the extract of component B with the extract of component A to obtain a mixed extract, stir evenly to obtain the Yuan-ion active fairy grass bath concentrate.

[0092] Comparative Example 5

[0093] The difference between this comparative example and the example is only that in the preparation of the saffron coating, shell powder is not added, specifically including the following steps:

[0094] S1. By weight, add saffron to 10 times the amount of water of the medicinal materials, heat to 95 °C under closed conditions, keep warm and extract for 2 hours, filter to obtain filtrate A and medicinal residues. Add 10 times the amount of water of the medicinal residue mass to the medicinal residues, heat to 95 °C again under closed conditions, keep warm and extract for 2 hours, filter to obtain filtrate B and medicinal residues, and combine filtrate A and filtrate B to obtain the saffron extract;

[0095] S2. Stir the saffron extract for 0.5 hours, heat to 40 °C, add 0.6% of polyvinyl alcohol based on the mass of the saffron extract, keep warm for 1 hour, concentrate under reduced pressure to a concentrated solution with a density of 1.13 g / ml, dry, and pass through a 200-mesh sieve to obtain the saffron coating.

[0096] Comparative Example 6

[0097] The difference between this comparative example and the examples is only that in the preparation of the saffron coating, polyvinyl alcohol was not added, and it specifically includes the following steps:

[0098] S1. By weight, add saffron to 10 times the amount of water of the medicinal materials. Under airtight conditions, heat to 95 °C, keep warm and extract for 2 h, filter to obtain filtrate A and medicinal residues. Add 10 times the amount of water of the mass of the medicinal residues to the medicinal residues. Under airtight conditions, heat to 95 °C again, keep warm and extract for 2 h, filter to obtain filtrate B and medicinal residues. Combine filtrate A and filtrate B to obtain the saffron extract;

[0099] S2. Add shell powder with a particle size range of 1000 mesh to the saffron extract. The mass of the shell powder is 1.2% of the mass of the saffron extract. Stir for 0.5 h, heat to 40 °C, add polyvinyl alcohol accounting for 0.6% of the mass of the saffron extract, keep warm for 1 h, concentrate under reduced pressure to a concentrated solution with a density of 1.13 g / ml, dry, and pass through a 200-mesh sieve to obtain the saffron coating.

[0100] Comparative Example 7

[0101] The difference between this comparative example and the examples is only that in the preparation of the saffron coating, neither shell powder nor polyvinyl alcohol was added, and it specifically includes the following steps:

[0102] S1. By weight, add saffron to 10 times the amount of water of the medicinal materials. Under airtight conditions, heat to 95 °C, keep warm and extract for 2 h, filter to obtain filtrate A and medicinal residues. Add 10 times the amount of water of the mass of the medicinal residues to the medicinal residues. Under airtight conditions, heat to 95 °C again, keep warm and extract for 2 h, filter to obtain filtrate B and medicinal residues. Combine filtrate A and filtrate B to obtain the saffron extract;

[0103] S2. Stir the saffron extract for 0.5 h, heat to 40 °C, keep warm for 1 h, concentrate under reduced pressure to a concentrated solution with a density of 1.13 g / ml, dry, and pass through a 200-mesh sieve to obtain the saffron coating.

[0104] Effect verification

[0105] Antibacterial performance test: Use the concentrated solutions of Examples 1-5 and Comparative Examples 1-7 as samples, configure them into 3% aqueous solutions, and the test method refers to QB / T2738-2005. The test bacterial strains are Candida albicans, Escherichia coli, and Staphylococcus aureus. Among them, the storage time is the time when the total bactericidal rate of each group of concentrated solutions drops to 85% of the initial total bactericidal rate.

[0106] Table 1

[0107]

[0108]

[0109] Result Analysis

[0110] Analysis of Examples 1 - 5 and Comparative Examples 1 - 7, combined with Table 1, shows that the meta - ionic active fairy - grass bath concentrate provided by the present invention has a high sterilization rate, good antibacterial effect, and has good inhibitory effects on Staphylococcus aureus, Escherichia coli, and Candida albicans. In addition, it can maintain good long - term effectiveness in terms of sterilization efficacy and has a long - term stable antibacterial effect. The specific analysis is as follows:

[0111] It can be seen from Comparative Examples 1 - 2 that extracting different - component drugs separately has a higher sterilization rate, indicating that targeted extraction of raw materials of Component A and Component B can improve the activity of effective antibacterial components in traditional Chinese medicine and has a good antibacterial effect.

[0112] It can be seen from Comparative Examples 3 - 7 that through the adsorption of the effective components of saffron by shell powder and the coating of polyvinyl alcohol, the prepared concentrate has a longer storage time, indicating that the addition of shell powder and polyvinyl alcohol can improve the long - term effectiveness of the drug's sterilization components, contribute to the long - term co - existence of the effective components of saffron and poria cocos, and finally make the prepared concentrate show a long - term stable antibacterial effect. In addition, shell powder and polyvinyl alcohol can have a synergistic effect, significantly improving the storage time of the prepared concentrate.

[0113] In addition, it should be noted that among the various specific technical features described in the above - mentioned specific embodiments, they can be combined in any suitable way without contradiction. To avoid unnecessary repetition, the present invention will not separately describe various possible combination methods.

[0114] In addition, any combination can be made among various different embodiments of the present invention, as long as it does not violate the idea of the present invention, it should also be regarded as the content disclosed by the present invention.

Claims

1. A meta-ion active fairy grass bath concentrate, characterized in that, The described meta-ion active fairy grass bath concentrate is composed of component A extract, component B extract and saffron coating. The specific weight ratios of the raw materials used in component A extract and component B extract are as follows: Component A is 30-35 parts of Poria cocos, 18-22 parts of Artemisia argyi, 8-10 parts of lotus leaf, 2-5 parts of rose, 10-20 parts of Leonurus japonicus, 10-15 parts of Perilla frutescens, 3-5 parts of Angelica dahurica, 2.5-3.5 parts of Saposhnikovia divaricata and 1-2 parts of Lycium barbarum; Component B is 18-22 parts of Pueraria lobata, 20-30 parts of Rhodiola rosea, 5-7 parts of Ligusticum chuanxiong and 20-30 parts of Millettia reticulata.

2. The concentrated liquid for fairy grass bath with meta-ion activity according to claim 1, wherein The preparation process of the described meta-ion active fairy grass bath concentrate includes the following steps: A1. By weight, weigh each raw material of component A, dry and crush it, add 5-10 times the amount of ethanol solution, soak it at room temperature for 10-20 hours, reflux and extract it twice in a water bath at 80-90 °C, combine the extracts, and concentrate the extracts to obtain component A extract; A2. By weight, weigh each raw material of component B, dry and crush it, add 8-12 times the amount of deionized water to obtain a slurry, add 1-2% of the strain activation solution to the slurry, ferment it at 35-40 °C for 2-3 days to obtain a fermented material, heat the fermented material to 95-100 °C, boil it for 1-2 hours, filter, and concentrate the filtrate to obtain component B extract; A3. Mix component B extract and component A extract to obtain a mixed extract, then add 1.0-1.2% of saffron coating based on the mass of the mixed extract, stir evenly to obtain the described meta-ion active fairy grass bath concentrate.

3. The meta-ion active fairy grass bath concentrate according to claim 1 or 2, characterized in that The preparation of the described saffron coating includes the following steps: S1. By weight, add saffron to 8-12 times the amount of water of the medicinal materials, heat it to 95-100 °C under closed conditions, keep it warm and extract for 1-2 hours, filter to obtain filtrate A and medicinal residues, add 8-12 times the amount of water to the medicinal residues, heat it to 95-100 °C again under closed conditions, keep it warm and extract for 1-2 hours, filter to obtain filtrate B and medicinal residues, and combine filtrate A and filtrate B to obtain saffron extract; S2. Add shell powder with a particle size range of 1000-1500 meshes to the saffron extract, the mass of the shell powder is 1-1.5% of the mass of the saffron extract, stir for 0.5-1 hour, heat it to 35-40 °C, add 0.5-0.7% of polyvinyl alcohol based on the mass of the saffron extract, keep it warm for 1-2 hours, concentrate it under reduced pressure to a concentrated solution with a density of 1.12-1.15 g / ml, dry it, and pass through a 200-mesh sieve to obtain the saffron coating.

4. A kind of elemental ion active fairy grass bath concentrate according to claim 2, characterized in that, In step A2, the preparation of the strain activation solution includes the following: Activate Bifidobacterium to obtain Bifidobacterium activation solution, activate Lactobacillus acidophilus strain to obtain Lactobacillus acidophilus activation solution, and mix the above two activation solutions to obtain the strain activation solution.

5. The concentrated liquid for fairy grass bath with meta-ion activity according to claim 2, wherein, In step A1, the concentration density of component A extract is 1.10-1.20 g / ml.

6. The concentrated liquid for medicated bath of active fairy grass with meta-ions according to claim 2, characterized in that In step A2, the concentration density of component B extract is 1.15-1.25 g / ml.

7. A meta-ion active fairy grass bath concentrate according to claim 2, characterized in that, In steps A1 and A2, the concentration process is concentration under reduced pressure.

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