Freeze drying device for voriconazole preparation and method thereof

Abstract

The invention relates to the technical field of freeze-drying devices, and discloses a freeze-drying device for voriconazole preparation and a method thereof.The freeze-drying device comprises a drying box internally provided with a cavity, a cabinet door is further arranged on the drying box, a plurality of movable storage plates are arranged in the cavity, mounting grooves are formed in the storage plates, and a plurality of placement grooves are formed in the lower side faces of the mounting grooves; notches are formed in the upper end faces of the storage plates, and clamping assemblies are arranged in the mounting grooves; a limiting assembly is further arranged in the mounting groove; a positioning assembly is further arranged in the mounting groove; a fixing groove is formed in the cabinet door, and a supporting assembly is arranged in the fixing groove; a drying assembly is further arranged in the cavity. By means of the structure, positioning of the positioning assembly on the storage plate is removed or removed, the storage plate can slide and ascend and descend in the cavity, the descended storage plate can bring convenience to a worker to take and place a container containing voriconazole on the storage plate, and therefore the worker can conveniently use the storage plate.

Description

Technical Field

[0001] The present invention relates to the technical field of freeze-drying devices, and more specifically, to a freeze-drying device and method for the preparation of voriconazole. Background Art

[0002] After the preparation of voriconazole, in order to improve its storage stability and extend its shelf life, voriconazole is usually placed in a freeze-drying device for freeze-drying. After voriconazole is freeze-dried by the freeze-drying device, the moisture in voriconazole will be sublimated and removed, so that voriconazole changes from a liquid to a powder, facilitating the long-term storage of voriconazole.

[0003] For example, a vacuum freeze-drying device disclosed in the patent with the publication number CN220601949U, although this vacuum freeze-drying device greatly facilitates the taking and placing of items to be dried through cooperation, is convenient for regularly cleaning the tray, improves work efficiency, and makes the vacuum freeze-drying chamber extremely convenient to use; however, when this vacuum freeze-drying device is actually used, the height of the tray cannot be adjusted. When the staff takes and places items on the high tray, it is inconvenient for the staff to take and place items on the high tray, resulting in inconvenient use of the tray by the staff. Summary of the Invention

[0004] The purpose of the present invention is to provide a freeze-drying device and method for the preparation of voriconazole to solve the problems raised in the above background art.

[0005] To achieve the above purpose, the present invention provides the following technical solutions: A freeze-drying device for the preparation of voriconazole, including a drying box with an internal cavity, and a door that can be opened and closed is also provided on the drying box. A plurality of movable placement plates are arranged in the cavity from top to bottom. Installation grooves with one side open are formed in the placement plates. A plurality of placement grooves are formed on the lower side surface of the installation grooves. A plurality of notches communicating with the placement grooves are formed on the upper end surfaces of the placement plates. Containers containing voriconazole are placed in the corresponding placement grooves through the notches. A clamping component is arranged in the installation groove, and the upward movement of the placement plate is used to drive the clamping component to clamp and fix the containers in the placement grooves; A limiting component is also arranged in the installation groove, and the clamping component is used to drive the limiting component to limit the placement plate in the cavity; A positioning component is also arranged in the installation groove, and the upward movement of the placement plate is used to drive the positioning component to position the position of the placement plate after upward movement; A fixing groove with one side open is formed on the door. A supporting component is arranged in the fixing groove, and the closing of the door is used to drive the supporting component to support one end of the placement plate; A drying component is also provided in the cavity, and the drying component is used to freeze-dry voriconazole in the container.

[0006] Preferably, first clamping plates are provided on the lower side surface of the installation groove and on one side of the placement groove. The clamping component includes a plurality of lifting plates provided in the cavity. The lifting plates are vertically movable. Clamping brackets are provided on the lifting plates, with one end of each clamping bracket extending into the corresponding installation groove and being movable. A plurality of second clamping plates are provided on the clamping brackets, and the second clamping plates are all located on the other side of the corresponding placement groove. The clamping brackets drive the plurality of second clamping plates to move towards the corresponding first clamping plates, so as to clamp and fix the containers in the placement grooves. A plurality of driving members are also provided in the cavity, and the driving members are used to drive the moving clamping brackets.

[0007] Preferably, a through groove penetrating the placement plate is formed along the length direction on one side wall of the installation groove. A through plate with one end extending out of the through groove is provided on the clamping bracket. An extrusion block is provided on the extending end of the through plate, and a first inclined surface is formed on the extrusion block. The driving members include a plurality of matching blocks provided on the side wall of the cavity. Second inclined surfaces matching the corresponding first inclined surfaces are formed on the matching blocks. When the placement plate drives the clamping bracket to move upward, the second inclined surfaces on the matching blocks extrude the first inclined surfaces, so as to realize the movement of the clamping bracket.

[0008] Preferably, a vertical plate is provided on the lifting plate. A through rod with one end penetrating the vertical plate is provided on the clamping bracket. A through ring is sleeved on the through rod, and a first spring is sleeved on the through rod between the through ring and the vertical plate. The first spring is used to push the through ring away from the vertical plate.

[0009] Preferably, a limiting plate is provided in the cavity, and a vertical limiting groove is formed on the limiting plate. The limiting component includes a limiting rod provided on the clamping bracket. When the clamping bracket moves, one end of the limiting rod is driven to penetrate the placement plate and insert into the limiting groove, so as to limit the placement plate in the cavity by the limiting rod.

[0010] Preferably, opposite inserting plates are provided in the cavity, and a plurality of inserting holes are formed on each inserting plate. The positioning component includes opposite positioning blocks provided on the lower end surface of the placement plate. The positioning blocks are movable. Telescopic inserting rods are provided on the positioning blocks. A moving member is provided on the placement plate between the two positioning blocks. The moving member is used to drive the two positioning blocks to move away from each other. When the placement plate moves upward, the inserting rods on the positioning blocks are driven to insert into the corresponding inserting holes, so as to position the placement plate after it moves upward.

[0011] Preferably, opposite first mounting plates are provided on the lower end surface of the storage plate. Moving plates are provided on the first mounting plates. Third inclined surfaces are formed on the moving plates. Opposite supports are provided on both sides of the lower end surface of the storage plate. Second mounting plates are provided on the positioning blocks. Positioning rods opposite to each other and passing through the two supports are provided on the second mounting plates. The penetrating ends of the two positioning rods are connected to the corresponding first mounting plates; The moving member includes a rotatable threaded rod provided on the lower end surface of the storage plate. A rotatable threaded block is sleeved on the threaded rod. Extrusion plates are provided on both sides of the threaded block. Fourth inclined surfaces matching the corresponding third inclined surfaces are formed at one ends of the extrusion plates. The rotation of the threaded rod drives the fourth inclined surfaces on the extrusion plates to extrude the corresponding third inclined surfaces, so as to realize the mutual separation of the two positioning blocks.

[0012] Preferably, the supporting assembly includes a plurality of round rods provided in the fixing groove. The round rods are rotatably arranged. A plurality of supporting plates are sleeved on the round rods. The rotation of the round rods drives the supporting plates to abut against the lower end surface of the corresponding storage plate, so as to realize the support of the storage plate. A rotating member is further provided in the fixing groove. The closing of the cabinet door drives the rotating member to drive the round rods to rotate.

[0013] Preferably, a fixing block is provided on the drying box. A fixing inclined surface is formed on the fixing block. A circular hole communicating with the fixing groove is formed on the upper end surface of the cabinet door. A circular groove is formed on the cabinet door at the position of the circular hole. Gears are sleeved on the round rods. Opposite fixing rods are provided in the fixing groove. A first fixing plate and a second fixing plate are provided in the fixing groove. Both ends of the first fixing plate and the second fixing plate are sleeved on the corresponding fixing rods. A second spring is sleeved on the fixing rod below the second fixing plate. A rack meshing with a plurality of gears is provided between the first fixing plate and the second fixing plate; The rotating member includes a connecting rod provided on the second fixing plate and having one end passing through the circular hole and the circular groove. A convex rod is provided on the protruding end of the connecting rod. An extrusion inclined surface matching the fixing inclined surface is formed on the convex rod. The closing of the cabinet door drives the fixing inclined surface to extrude the extrusion inclined surface, so as to realize the rotation of the round rod.

[0014] A voriconazole freeze-drying method uses the above-mentioned freeze-drying device for preparing voriconazole, and specifically includes the following steps: S1. First, open the cabinet door, and move the storage plate in the cavity to the lowest position. Then, pull the topmost storage plate a certain distance towards the opening of the cavity. At this time, place the container containing voriconazole on the topmost storage plate and place it in the corresponding placement groove through the notch. Then, reset the pulled storage plate; S2. After the storage board is reset, the staff needs to drive the positioning component. After the positioning component is driven, the staff moves the storage board upward. The upward movement of the storage board can drive the clamping component. At this time, the clamping component in the installation groove can clamp and fix the container in the placement groove. At the same time, the clamping component drives the limiting component to limit the storage board, so that the storage board can only move up and down in the cavity. When the storage board moves up to an appropriate height, the positioning component automatically positions the storage board. Then, the container is placed in the corresponding placement groove by performing the above operations in sequence from top to bottom, and the storage board is moved up to an appropriate height; S3. When the storage board in the cavity is moved up, when the staff closes the cavity through the cabinet door, the cabinet door can drive the support component. After the cabinet door closes the cavity, the support component can support one end of the storage board to prevent the storage board from tilting in the cavity; S4. Finally, the voriconazole in the cavity can be freeze-dried through the drying component; S5. When the voriconazole is freeze-dried, open the cabinet door. At this time, the staff needs to release the positioning of the positioning component on the lowermost storage board. Then, move the lowermost storage board down to the lowest position. At the same time, the clamping component releases the clamping of the container, and the clamping component also drives the limiting component to release the limit on the storage board. At this time, the staff can pull the lowermost storage board out of the cavity to facilitate the staff to take the container on the storage board. After taking it, reset the storage board. Then, repeat the above steps and operate from top to bottom to take the containers on other storage boards.

[0015] Compared with the prior art, the beneficial effects of the present invention are: 1. In the present invention, by releasing or removing the positioning of the positioning component on the storage board, the storage board can slide up and down in the cavity. Compared with the existing ones, when this freeze-drying device for preparing voriconazole is actually used, the lowered storage board can facilitate the staff to take and place the container containing voriconazole on the storage board, thus facilitating the staff to use the storage board.

[0016] In the present invention, after the cabinet door closes the cavity, the support component can support one end of the storage board to prevent the storage board from tilting in the cavity, making the freeze-drying effect of voriconazole on the storage board better.

[0017] In the present invention, the upward movement of the storage board can drive the clamping component. At this time, the clamping component in the installation groove can clamp and fix the container in the placement groove, thereby preventing the container containing voriconazole from shaking in the placement groove when the storage board moves up, causing voriconazole to spill out of the container. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a schematic structural diagram of a freeze-drying device for the preparation of voriconazole in the present invention.

[0019] Figure 2 This is a schematic structural diagram of the placement plate installed in the cavity in the present invention.

[0020] Figure 3 This is a schematic structural diagram of the plug-in and limit plate installed in the cavity in the present invention.

[0021] Figure 4 This is a schematic structural diagram of the placement plate, plug plate and limit plate in the present invention.

[0022] Figure 5 This is a schematic structural diagram of the placement plate in the present invention.

[0023] Figure 6 This is a schematic structural diagram of the inside of the installation groove in the present invention.

[0024] Figure 7 This is a schematic structural diagram of the lower end face of the placement plate in the present invention.

[0025] Figure 8 This is an exploded structural diagram of the positioning block in the present invention.

[0026] Figure 9 This is a partial structural diagram of the clamping frame in the present invention.

[0027] Figure 10 This is a schematic structural diagram of the cabinet door in the present invention.

[0028] Figure 11 This is a schematic structural diagram of the connecting rod and the convex rod in the present invention.

[0029] Figure 12 This is a schematic structural diagram of the round hole and the round groove in the present invention.

[0030] The meanings of the labels in the figure are as follows: 100, drying oven; 110, cabinet door; 111, locking plate; 112, bolt; 120, fixing block; 200, placement plate; 201, cavity; 210, mating block; 220, plug plate; 230, knob; 240, vertical rod; 250, mounting seat; 251, mounting rod; 300, limit plate; 301, limit groove; 400, lifting plate; 410, limit rod; 501, through groove; 510, extrusion block; 520, clamping block; 601. Installation groove; 610. First clamping plate; 620. Clamping bracket; 621. Second clamping plate; 622. Clamping groove; 630. Through rod; 631. Through ring; 700. Positioning block; 701. Insertion rod; 702. Second mounting plate; 710. Positioning rod; 720. First mounting plate; 721. Moving plate; 730. Support; 740. Threaded rod; 741. Threaded block; 742. Extrusion plate; 743. Threaded ring; 744. Threaded seat; 750. Slide block; 751. Slide groove; 760. Fourth spring; 800. Insertion ring; 810. Intercepting ring; 820. Third spring; 1000. Through plate; 1010. Vertical plate; 1020. First spring; 1031. Card slot; 1040. Lifting seat; 1050. Slide rod; 1051. Limit block; 1100. Round rod; 1101. Support plate; 1110. Gear; 1120. Fixed rod; 1121. Connecting rod; 1130. First fixing plate; 1131. Second fixing plate; 1132. Second spring; 1140. Rack; 1151. Fixed slot; 1160. Rotating seat; 1210. Convex rod; 1301. Round hole; 1302. Round groove. Detailed implementation manners

[0031] To further understand the content of the present invention, the present invention will be described in detail with reference to the accompanying drawings and embodiments. It should be understood that the embodiments are only for explaining the present invention rather than limiting it.

[0032] The following is a further detailed description of this embodiment in combination with the attached Figures 1-12 This embodiment will be further described in detail.

[0033] As Figure 1 shown, a freeze-drying device for the preparation of voriconazole in this embodiment includes a drying box 100 with an internal cavity 201. The drying box 100 is also provided with an openable cabinet door 110. Inside the cavity 201, there are multiple movable placement plates 200 arranged from top to bottom. Each placement plate 200 is provided with an installation groove 601 with an opening on one side. Multiple placement grooves are opened on the lower side surface of the installation groove 601. Multiple notches communicating with the placement grooves are opened on the upper end surface of the placement plate 200. The container containing voriconazole is placed in the corresponding placement groove through the notch. A clamping assembly is arranged in the installation groove 601, and the upward movement of the placement plate 200 is used to drive the clamping assembly to clamp and fix the container in the placement groove; A limiting assembly is also arranged in the installation groove 601, and the clamping assembly is used to drive the limiting assembly to limit the placement plate 200 in the cavity 201; The storage board 200 is also provided with a positioning component. When the storage board 200 moves upward, it drives the positioning component to position the position of the storage board 200 after moving upward. A fixing groove 1151 with an opening on one side is formed on the cabinet door 110. A supporting component is arranged in the fixing groove 1151. When the cabinet door 110 is closed, it drives the supporting component to support one end of the storage board 200. A drying component is also arranged in the cavity 201. The drying component is used for freeze-drying voriconazole in the container.

[0034] In this embodiment, open the cabinet door 110, place the container containing voriconazole in the corresponding placement groove through the notch, and then close the opening of the cavity 201 through the cabinet door 110. At this time, the voriconazole in the container can be freeze-dried through the drying component in the cavity 201. After the voriconazole in the container is completely freeze-dried, open the cabinet door 110 and take out the container containing voriconazole in the placement groove. Among them, the drying component includes a compressor and a condenser installed in the drying box 100. A vacuum pump is also installed in the drying box 100. Through the cooperation of the compressor and the condenser, the voriconazole in the cavity 201 can be frozen. When the voriconazole in the container is completely frozen, the cavity 201 is pumped through the vacuum pump, so that the cavity 201 is in a low-pressure environment. At this time, the completely frozen voriconazole begins to sublimate, and the moisture in the voriconazole begins to be removed, realizing the freeze-drying of voriconazole. Among them, a heating plate is fixedly installed in the cavity 201. The temperature in the cavity 201 is heated through the heating plate, so that the voriconazole in the container can be heated, so that the voriconazole in the container can be further sublimated, so as to better remove the moisture in the voriconazole. The sublimated moisture can be collected by the cold trap in the cavity 201. Among them, an intake pipe communicating with the inside of the cavity 201 is installed on the drying box 100. A gas valve is installed in the intake pipe. When the voriconazole in the cavity 201 is completely freeze-dried, the gas valve needs to be opened to allow the outside air to enter the cavity, and then the vacuum pump is closed. At this time, the cabinet door 110 can be opened and the container containing voriconazole on the storage board 200 can be taken out. Among them, when the staff places the container containing voriconazole on the storage plate 200, a part of the storage plate 200 in the cavity 201 has a certain height. At this time, it is inconvenient for the staff to place the container containing voriconazole on the storage plate 200. When the staff needs to place the container containing voriconazole on the storage plate 200, the staff drives the positioning component to release the positioning of the storage plate 200, so that the storage plate 200 can be lifted and lowered in the cavity 201. When the staff lowers all the storage plates 200 in the cavity 201 to the lowest position, the downward movement of the storage plate 200 will drive the limiting component, so that the limiting component will release the limitation of the storage plate 200. At this time, the staff can pull the uppermost storage plate 200 out of the cavity 201 by a certain distance, so that the staff can place the container containing voriconazole in the corresponding placement groove through the notch. Then, the staff resets the pulled storage plate 200. After the storage plate 200 is reset, the staff needs to drive the positioning component. After the positioning component is driven, the staff raises the storage plate 200. The upward movement of the storage plate 200 can drive the clamping component. At this time, the clamping component in the installation groove 601 can clamp and fix the container in the placement groove, so as to avoid the container containing voriconazole shaking in the placement groove when the storage plate 200 moves upward, resulting in the spillage of voriconazole from the container. At the same time, the clamping component also drives the limiting component to limit the storage plate 200, so that the storage plate 200 can only be lifted and lowered in the cavity 201, thus avoiding the storage plate 200 sliding out of the cavity 201 when the storage plate 200 moves upward, which affects the actual use. When the storage plate 200 moves upward to a suitable height, the positioning component will automatically position the position of the storage plate 200. Then, repeat the above operation to place the subsequent containers in the corresponding placement grooves and move the storage plate 200 upward to a suitable height, so as to facilitate the staff to place the containers containing voriconazole on the storage plates 200 at different heights; Among them, when voriconazole is frozen on the storage plate 200, it is necessary to ensure the horizontal placement of the storage plate 200. When voriconazole is frozen on the inclined storage plate 200, it will affect the freeze-drying effect of voriconazole on the storage plate 200. When the staff closes the cavity 201 through the cabinet door 110, the cabinet door 110 can drive the support component. After the cabinet door 110 closes the cavity 201, the support component can support one end of the storage plate 200 to avoid the inclination of the storage plate 200 in the cavity 201, so that the freezing effect of voriconazole on the storage plate 200 is better; Among them, after voriconazole is freeze-dried, when the cabinet door 110 is opened, at this time, the positioning of the placement plate 200 at the bottom of the cavity 201 is released through the positioning component. Then, the bottom placement plate 200 is moved down to the lowest position. At the same time, the clamping component releases the clamping of the container, and the clamping component also drives the limiting component to release the limitation on the placement plate 200. At this time, the staff can pull the moved-down placement plate 200 out of the cavity 201, so that the staff can take the container on the placement plate 200. After the taking is completed, by repeating the above steps, the containers on other placement plates 200 can be taken; Among them, by releasing the positioning of the placement plate 200 by the positioning component or releasing the positioning, the placement plate 200 can slide up and down in the cavity 201. Compared with the existing ones, when this freeze-drying device for preparing voriconazole is actually used, the moved-down placement plate 200 can facilitate the staff to take and place the container containing voriconazole on the placement plate 200, thus facilitating the staff to use the placement plate 200; Among them, opposite mounting seats 250 are fixedly installed on the side wall of the drying box 100, and a mounting rod 251 is fixedly installed between the two mounting seats 250. A rotating seat 1160 sleeved on the mounting rod 251 is fixedly installed on one side wall of the cabinet door 110. Through the cooperation of the rotating seat 1160 and the mounting rod 251, the installation of the cabinet door 110 on the drying box 100 is realized. By driving the cabinet door 110 to rotate along the mounting rod 251, the opening and closing of the opening of the cavity 201 by the cabinet door 110 can be realized; Among them, a locking plate 111 is fixedly installed on the other side wall of the cabinet door 110, and a bolt 112 with one end threadedly penetrating through the locking plate 111 is installed on the locking plate 111. When the cabinet door 110 closes the opening of the cavity 201, one end of the bolt 112 will be threadedly inserted into the side wall of the drying box 100 to realize the continuous closing of the cabinet door 110 on the cavity 201; When it is actually used, a sealing gasket is fixedly installed on the side wall of the cabinet door 110 facing the cavity 201. When the cabinet door 110 closes the cavity 201, the cabinet door 110 abuts against the opening of the cavity 201 through the sealing gasket to realize the sealing of the opening of the cavity 201 by the cabinet door 110.

[0035] As Figures 1-9 shown, in this embodiment, first clamping plates 610 are provided on the lower side surface of the installation groove 601 and on one side of the placement groove; The clamping assembly includes a plurality of lifting plates 400 provided in the cavity 201. The lifting plates 400 are arranged to be liftable. Each lifting plate 400 is provided with a clamping bracket 620 whose one end extends into the corresponding installation groove 601 and is movable. The clamping bracket 620 is provided with a plurality of second clamping plates 621. The second clamping plates 621 are all located on the other side of the corresponding placement groove. The clamping bracket 620 drives the plurality of second clamping plates 621 to move towards the corresponding first clamping plate 610, so as to clamp and fix the container in the placement groove. A plurality of driving members are also provided in the cavity 201, and the driving members are used to drive the moving clamping bracket 620 to move upward.

[0036] In this embodiment, through the arrangement of the first clamping plate 610, the lifting plate 400, the clamping bracket 620, the second clamping plate 621 and the driving member, the first clamping plate 610 is fixedly installed on the lower side surface of the installation groove 601, and the second clamping plate 621 is fixedly installed on the clamping bracket 620. When the staff pushes the placement plate 200 to lift, the lifting of the placement plate 200 will drive the driving member. When the placement plate 200 moves upward, the driving member will drive the clamping bracket 620 to move, so that the second clamping plate 621 on the clamping bracket 620 moves towards the first clamping plate 610. At this time, the container containing voriconazole in the placement groove can be clamped and fixed by the first clamping plate 610 and the second clamping plate 621; Wherein, the side walls of the first clamping plate 610 and the second clamping plate 621 facing the placement groove are both arc-shaped, so that the first clamping plate 610 and the second clamping plate 621 can better clamp and fix the container; Wherein, opposite vertical rods 240 are fixedly installed in the cavity 201. Opposite lifting seats 1040 through which the corresponding vertical rods 240 penetrate are fixedly installed on the lifting plate 400. Through the cooperation of the lifting seats 1040 and the vertical rods 240, the lifting installation of the lifting plate 400 in the cavity 201 is realized; Wherein, a slot 1031 with a T-shaped cross-section is formed in the lifting plate 400 along its length direction. A block 520 with a T-shaped cross-section is fixedly installed on the clamping bracket 620. By clamping the block 520 into the slot 1031, the movable installation of the clamping bracket 620 on the lifting plate 400 is realized; Wherein, opposite sliders 750 are fixedly installed on the lower end surface of the placement plate 200. A sliding cavity with one side open is provided in each slider 750. Opposite sliding rods 1050 whose one ends extend into the corresponding sliding cavities are fixedly installed on the lifting plate 400. By sleeving the sliders 750 on the sliding rods 1050, the movable installation of the placement plate 200 in the cavity 201 is realized. At the same time, the placement plate 200 can slide out of the cavity 201 on the sliding rods 1050; In actual use, in order to prevent the storage plate 200 from sliding too much and causing the slider 750 to disengage from the sliding rod 1050, a sliding groove 751 communicating with the sliding cavity is formed in the side wall of the slider 750 along its length direction. A limiting block 1051 that is snapped into the corresponding sliding groove 751 is fixedly installed on the sliding rod 1050. Through the cooperation of the limiting block 1051 and the sliding groove 751, the limiting block 1051 can limit the sliding distance of the storage plate 200 on the sliding rod 1050, so as to prevent the storage plate 200 from sliding too much when sliding out of the cavity 201, resulting in the slider 750 on the storage plate 200 sliding out of the sliding rod 1050 and affecting the actual use.

[0037] As Figures 1-9 shown, in this embodiment, a through groove 501 penetrating the storage plate 200 is formed in one side wall of the installation groove 601 along its length direction. A through plate 1000 with one end extending out of the through groove 501 is provided on the clamping bracket 620. An extrusion block 510 is provided on the extending end of the through plate 1000, and a first inclined surface is formed on the extrusion block 510. The driving member includes a plurality of cooperation blocks 210 provided on the side wall of the cavity 201. Second inclined surfaces that are matched with the corresponding first inclined surfaces are formed on the cooperation blocks 210. When the storage plate 200 drives the clamping bracket 620 to move upward, the second inclined surface on the cooperation block 210 squeezes the first inclined surface, so as to realize the movement of the clamping bracket 620.

[0038] In this embodiment, through the settings of the through groove 501, the through plate 1000, the extrusion block 510, the first inclined surface, the cooperation block 210, and the second inclined surface, by fixedly installing the through plate 1000 on the clamping bracket 620, the extrusion block 510 on the through plate 1000, and the cooperation block 210 on the side wall of the cavity 201, when the storage plate 200 drives the clamping bracket 620 to move upward, the clamping bracket 620 can drive the extrusion block 510 to move upward through the through plate 1000. When the extrusion block 510 moves upward, the first inclined surface on the extrusion block 510 will pass through the second inclined surface on the cooperation block 210. When the first inclined surface passes through the second inclined surface, the second inclined surface will squeeze the first inclined surface, so that the extrusion block 510 can move towards the storage plate 200. When one end of the extrusion block 510 abuts against the side wall of the cooperation block 210 and slides, the extrusion block 510 moves to the maximum distance. At this time, the extrusion block 510 can drive the clamping bracket 620 to move through the through plate 1000, so that the second clamping plate 621 on the clamping bracket 620 moves towards the first clamping plate 610 and clamps and fixes the container in the placement groove. In actual use, the plurality of cooperation blocks 210 on the side wall of the cavity 201 are arranged along the height direction of the cavity 201, and the plurality of cooperation blocks 210 are staggered from each other.

[0039] As Figures 1-9As shown, in this embodiment, a vertical plate 1010 is provided on the lifting plate 400, a through rod 630 with one end passing through the vertical plate 1010 is provided on the clamping frame 620, a through ring 631 is sleeved on the through rod 630, and a first spring 1020 is sleeved on the through rod 630 between the through ring 631 and the vertical plate 1010. The first spring 1020 is used to push the through ring 631 away from the vertical plate 1010.

[0040] In this embodiment, through the arrangement of the vertical plate 1010, the through rod 630, the through ring 631 and the first spring 1020, by fixedly installing the vertical plate 1010 on the lifting plate 400, the through rod 630 on the clamping frame 620, and the through ring 631 on the through rod 630. When the clamping frame 620 drives the second clamping plate 621 to move towards the first clamping plate 610, the clamping frame 620 will also drive the through ring 631 to move through the through rod 630. The movement of the through ring 631 can compress the first spring 1020. When the placing plate 200 drives the clamping frame 620 to move downwards, the clamping frame 620 drives the extrusion block 510 to move downwards through the through plate 1000. When the extrusion block 510 moves downwards and the first inclined surface on the extrusion block 510 is disengaged from the second inclined surface, the first spring 1020 is released from compression. The first spring 1020 pushes the through ring 631 away from the vertical plate 1010. The movement of the through ring 631 can drive the clamping frame 620 to move through the through rod 630. The movement of the clamping frame 620 drives the second clamping plate 621 to move away from the first clamping plate 610. At this time, the clamping of the container in the placing groove by the first clamping plate 610 and the second clamping plate 621 is released. During actual use, when the second clamping plate 621 on the clamping frame 620 clamps the container with the first clamping plate 610, the clamping frame 620 can limit the placing plate 200 to a certain extent. At this time, the placing plate 200 cannot slide out of the cavity 201.

[0041] As Figures 1-7 As shown, in this embodiment, a limiting plate 300 is provided in the cavity 201, and a vertical limiting groove 301 is opened on the limiting plate 300. The limiting component includes a limiting rod 410 provided on the clamping frame 620. The movement of the clamping frame 620 is used to drive one end of the limiting rod 410 to pass through the placing plate 200 and insert into the limiting groove 301, so as to limit the placing plate 200 in the cavity 201 by the limiting rod 410.

[0042] In this embodiment, when the storage plate 200 moves upward and the first clamping plate 610 and the second clamping plate 621 clamp and fix the container, the upward-moving storage plate 200 may slide out of the cavity 201. At this time, the first clamping plate 610 will exert a certain force on the container, which may cause the container to break, thus affecting the actual use. Through the settings of the limiting plate 300, the limiting groove 301 and the limiting rod 410, the limiting plate 300 is fixedly installed in the cavity 201, and the limiting rod 410 is fixedly installed on the clamping frame 620. When the clamping frame 620 moves to drive the second clamping plate 621 to move towards the first clamping plate 610, the clamping frame 620 will also drive one end of the limiting rod 410 to pass through the storage plate 200 and insert into the limiting groove 301. At this time, the storage plate 200 is limited in the cavity 201 by the limiting rod 410, so as to avoid the upward-moving storage plate 200 from sliding out of the cavity 201 and prevent the first clamping plate 610 from squeezing the container and causing it to break; Wherein, when the clamping frame 620 moves to drive the second clamping plate 621 away from the first clamping plate 610, the clamping frame 620 will also drive one end of the limiting rod 410 to retract into the installation groove 601. At this time, the storage plate 200 can slide out of the cavity 201; During its actual use, when the storage plate 200 is pulled towards the opening of the cavity 201, there is interference between the first clamping plate 610 and the clamping frame 620. To avoid interference between the first clamping plate 610 and the clamping frame 620, a plurality of clamping grooves 622 are formed on the clamping frame 620. When the storage plate 200 is pulled towards the opening of the cavity 201, the first clamping plate 610 will pass through the corresponding clamping grooves 622, so as to avoid interference between the first clamping plate 610 and the clamping frame 620; As Figures 1-8 shown, in this embodiment, opposite inserting plates 220 are provided in the cavity 201, and a plurality of inserting holes are formed on each of the inserting plates 220; The positioning assembly includes opposite positioning blocks 700 provided on the lower end surface of the storage plate 200. The positioning blocks 700 are movably arranged, and telescopic inserting rods 701 are provided on each of the positioning blocks 700. A moving member is provided on the storage plate 200 between the two positioning blocks 700. The moving member is used to drive the two positioning blocks 700 to move away from each other. When the storage plate 200 moves upward, it is used to drive the inserting rods 701 on the positioning blocks 700 to insert into the corresponding inserting holes, so as to position the position of the storage plate 200 after it moves upward.

[0043] In this embodiment, through the settings of the insertion plate 220, the jack, the positioning block 700, the insertion rod 701 and the moving member, by fixedly installing the insertion plate 220 in the cavity 201, when the storage plate 200 is located below the cavity 201 and has not been lifted, the two positioning blocks 700 are driven to move away from each other by the moving member. The movement of the positioning block 700 will drive the insertion rod 701 to move, and one end of the insertion rod 701 will be pressed against the insertion plate 220. At this time, the insertion rod 701 in the positioning block 700 is in a compressed state. When the staff drives the storage plate 200 to move up and makes the compressed insertion rod 701 move to the corresponding jack, the insertion rod 701 is released from compression, so that one end of the insertion rod 701 can be inserted into the corresponding jack, realizing the positioning of the position of the storage plate 200 after it is lifted; Wherein, a positioning groove for inserting one end of the insertion rod 701 is formed on one side wall of the positioning block 700. An insertion ring 800 is fixedly installed on the insertion rod 701 located in the positioning groove. An intercepting ring 810 for intercepting the insertion ring 800 is fixedly installed at the opening of the positioning groove. A third spring 820 is installed in the positioning groove. The third spring 820 is used to push the insertion ring 800 towards the intercepting ring 810, realizing the telescopic installation of the insertion rod 701 on the positioning block 700. When the positioning block 700 drives the insertion rod 701 to press against the insertion plate 220, the insertion rod 701 compresses the third spring 820 through the insertion ring 800. When the storage plate 200 moves up to the position of the jack, the third spring 820 is released from compression. The third spring 820 pushes the insertion ring 800 towards the intercepting ring 810, and one end of the insertion rod 701 is inserted into the corresponding jack, so as to realize the positioning of the position of the storage plate 200 after it is lifted; During its actual use, multiple jacks on the insertion plate 220 are arranged along its height direction, and the multiple jacks are staggered from each other, so as to avoid the insertion rod 701 being inserted into the wrong jack.

[0044] As Figures 1-7 shown, in this embodiment, opposite first mounting plates 720 are provided on the lower end surface of the storage plate 200. Moving plates 721 are provided on the first mounting plates 720. Third inclined surfaces are formed on the moving plates 721. Opposite supports 730 are provided on both sides of the lower end surface of the storage plate 200. Second mounting plates 702 are provided on the positioning blocks 700. Positioning rods 710 that are opposite and penetrate through the two supports 730 are provided on the second mounting plates 702. The penetrating ends of the two positioning rods 710 are connected to the corresponding first mounting plates 720; The moving member includes a rotatable threaded rod 740 provided on the lower end surface of the storage plate 200. A rotatable threaded block 741 is sleeved on the threaded rod 740. Extrusion plates 742 are provided on both sides of the threaded block 741. Fourth inclined surfaces that cooperate with the corresponding third inclined surfaces are formed at one end of each extrusion plate 742. The rotation of the threaded rod 740 drives the fourth inclined surface on the extrusion plate 742 to extrude the corresponding third inclined surface, so as to realize the mutual separation of the two positioning blocks 700.

[0045] In this embodiment, through the settings of the first mounting plate 720, the moving plate 721, the third inclined surface, the support 730, the second mounting plate 702, the positioning rod 710, the threaded rod 740, the threaded block 741, the extrusion plate 742 and the fourth inclined surface, the moving plate 721 is fixedly installed on the first mounting plate 720, the support 730 is fixedly installed on the storage plate 200, the second mounting plate 702 is fixedly installed on the positioning block 700, one end of the positioning rod 710 is fixedly installed on the second mounting plate 702, and the other end of the positioning rod 710 passes through the two supports 730 and is connected to the corresponding first mounting plate 720, so as to realize the installation of the positioning block 700 and the first mounting plate 720 under the storage plate 200. The side wall of the threaded block 741 is in sliding fit with the side wall of the storage plate 200. When the threaded rod 740 rotates, the threaded rod 740 can drive the threaded block 741 to move. The movement of the threaded block 741 can drive the two extrusion plates 742 to move. The movement of the extrusion plates 742 can extrude the third inclined surface through the fourth inclined surface, so that the moving plate 721 can drive the first mounting plate 720 to move. The movement of the first mounting plate 720 can drive the second mounting plate 702 to move through the positioning rod 710. The movement of the second mounting plate 702 can drive the corresponding positioning block 700 to move towards the insertion plate 220; Wherein, fourth springs 760 are sleeved on the positioning rods 710 between the supports 730 and the first mounting plate 720. When the first mounting plate 720 moves towards the insertion plate 220, the first mounting plate 720 compresses the fourth springs 760. When it is necessary to slide one end of the insertion rod 701 out of the insertion hole to release the positioning of the storage plate 200, by rotating the threaded rod 740, the threaded rod 740 drives the threaded block 741 to move, so that the extrusion plate 742 on the threaded block 741 releases the extrusion of the moving plate 721. At this time, the fourth springs 760 start to reset, and the fourth springs 760 push the first mounting plate 720 to move towards the threaded rod 740. The movement of the first mounting plate 720 can drive the second mounting plate 702 to move through the positioning rod 710. The second mounting plate 702 drives the positioning block 700 to move away from the insertion plate 220 and makes the insertion rod 701 on the positioning block 700 slide out of the insertion hole, so as to release the positioning of the storage plate 200; Among them, two threaded seats 744 are installed at a certain height on the lower end surface of the storage plate 200. The two ends of the threaded rod 740 are positioned and sleeved on the corresponding threaded seats 744 through bearings, realizing the rotational installation of the threaded rod 740 below the storage plate 200. A knob 230 is fixedly installed at one end of the threaded rod 740 facing the cavity 201, and the knob 230 facilitates driving the threaded rod 740 to rotate. During actual use, a threaded ring 743 is fixedly installed on the threaded rod 740. The threaded ring 743 limits the moving distance of the threaded block 741, thereby being able to prevent the threaded block 741 from driving the pressing plate 742 to move too much, resulting in the fourth inclined surface on the pressing plate 742 being disengaged from the cooperation with the third inclined surface.

[0046] As Figures 1-10 shown, in this embodiment, the support assembly includes a plurality of round rods 1100 provided in the fixing groove 1151. The round rods 1100 are rotatably arranged, and a plurality of support plates 1101 are sleeved on each round rod 1100. The rotation of the round rods 1100 drives the support plates 1101 to abut against the lower end surface of the corresponding storage plate 200, realizing the support of the storage plate 200. A rotating member is also provided in the fixing groove 1151. When the cabinet door 110 is closed, the rotating member is driven to drive the round rods 1100 to rotate.

[0047] In this embodiment, through the arrangement of the round rods 1100, the support plates 1101 and the rotating member, the two ends of the round rods 1100 are rotatably installed in the side wall of the fixing groove 1151 through bearings, and the support plates 1101 are fixedly sleeved on the round rods 1100. When the cabinet door 110 is closed, the cabinet door 110 can drive the rotating member, and the rotating member drives a plurality of round rods 1100 to rotate synchronously, so that the support plates 1101 on the round rods 1100 also rotate. After the support plates 1101 complete the rotation, one ends of the support plates 1101 abut against the lower end surface of the corresponding storage plate 200, realizing the support of the support plates 1101 for the storage plate 200, thereby being able to prevent one end of the storage plate 200 facing the opening of the cavity 201 from tilting.

[0048] As Figures 1-12As shown in the figure, in this embodiment, a fixing block 120 is provided on the drying oven 100. A fixing inclined surface is formed on the fixing block 120. A circular hole 1301 communicating with the fixing groove 1151 is formed on the upper end surface of the cabinet door 110. A circular groove 1302 is formed on the cabinet door 110 at the position of the circular hole 1301. Gears 1110 are sleeved on the circular rods 1100. Opposite fixing rods 1120 are provided in the fixing groove 1151. A first fixing plate 1130 and a second fixing plate 1131 are provided in the fixing groove 1151. Both ends of the first fixing plate 1130 and the second fixing plate 1131 are sleeved on the corresponding fixing rods 1120. A second spring 1132 is sleeved on the fixing rod 1120 below the second fixing plate 1131. A rack 1140 meshing with a plurality of gears 1110 is provided between the first fixing plate 1130 and the second fixing plate 1131; The rotating member includes a connecting rod 1121 provided on the second fixing plate 1131 and having one end passing through the circular hole 1301 and the circular groove 1302. A convex rod 1210 is provided on the protruding end of the connecting rod 1121. An extrusion inclined surface matching with the fixing inclined surface is formed on the convex rod 1210. When the cabinet door 110 is closed, the fixing inclined surface is driven to extrude the extrusion inclined surface, so as to realize the rotation of the circular rod 1100.

[0049] In this embodiment, through the arrangements of the fixing block 120, the fixing inclined surface, the round hole 1301, the round groove 1302, the gear 1110, the fixing rod 1120, the first fixing plate 1130, the second fixing plate 1131, the second spring 1132, the rack 1140, the connecting rod 1121, the convex rod 1210 and the extrusion inclined surface, by fixedly installing the fixing block 120 on the drying oven 100, fixedly installing the gear 1110 on the round rod 1100, fixedly installing both ends of the fixing rod 1120 on the side wall of the fixing groove 1151, respectively fixedly installing and connecting both ends of the rack 1140 to the first fixing plate 1130 and the second fixing plate 1131, and sleeving both ends of the first fixing plate 1130 and the second fixing plate 1131 on the corresponding fixing rods 1120, the installation of the first fixing plate 1130, the second fixing plate 1131 and the rack 1140 in the fixing groove 1151 is realized. The connecting rod 1121 is fixedly installed on the second fixing plate 1131, and the convex rod 1210 is fixedly installed on the connecting rod 1121. When the cabinet door 110 is closed, the convex rod 1210 on the cabinet door 110 will be closed with the fixing inclined surface on the fixing block 120 through the extrusion inclined surface. When the cabinet door 110 is closed, the fixing inclined surface extrudes the extrusion inclined surface, causing the convex rod 1210 to move down into the round groove 1302. The downward movement of the convex rod 1210 can drive the first fixing plate 1130 to move down through the connecting rod 1121. The downward movement of the first fixing plate 1130 can drive the rack 1140 to move down. The downward movement of the rack 1140 can drive a plurality of gears 1110 to rotate. The rotation of the gears 1110 drives the corresponding round rods 1100 to rotate, realizing the rotation of the round rods 1100 to drive the support plate 1101 to support the lower end of the storage plate 200; Among them, when the rack 1140 moves down, the rack 1140 can drive the second fixing plate 1131 to compress the second spring 1132. When the cabinet door 110 is opened, the convex rod 1210 is disengaged from the fixing block 120. At the same time, the second spring 1132 is released from compression. The second spring 1132 pushes the second fixing plate 1131 to move up. The upward movement of the second fixing plate 1131 can drive the rack 1140 to move up. The upward movement of the rack 1140 drives a plurality of gears 1110 to rotate. The rotation of the gears 1110 drives the corresponding round rods 1100 to rotate. At this time, the rotation of the round rods 1100 drives the support plate 1101 to rotate, so that one end of the support plate 1101 rotates into the fixing groove 1151, thereby avoiding one end of the support plate 1101 protruding outside the fixing groove 1151 and easily hurting the staff. The upward movement of the rack 1140 can also drive the first fixing plate 1130 to move up. The upward movement of the first fixing plate 1130 can drive the convex rod 1210 to always maintain a state where the upper end extends outside the cabinet door 110 through the connecting rod 1121; In actual use, a sealing washer is installed on the lower end surface of the convex rod 1210. When the cabinet door 110 is closed, the lower end surface of the convex rod 1210 abuts against the lower end surface of the circular groove 1302 through the sealing washer, which can prevent external air from entering the circular hole 1301 from the circular groove 1302, then entering the fixing groove 1151 from the circular hole 1301, and then flowing into the cavity 201.

[0050] This embodiment also provides a voriconazole freeze-drying method, which uses the above-mentioned freeze-drying device for preparing voriconazole, and specifically includes the following steps: S1. First, turn the bolt 112 out of the side wall of the drying oven 100, then turn the cabinet door 110 to release the closing of the cabinet door 110 on the cavity 201. Then, turn the lowermost knob 230. The threaded rod 740 is driven to rotate by the knob 230, and the threaded rod 740 drives the threaded block 741 to move towards the knob 230. At the same time, the fourth spring 760 pushes the insertion rod 701 on the positioning block 700 out of the insertion hole, releases the positioning of the storage plate 200, and moves the released storage plate 200 to the lowest position. Repeat the above operation to move multiple storage plates 200 in the cavity 201 to the lowest position. Then, pull the uppermost storage plate 200 out of the cavity 201. At this time, the container containing voriconazole can be sequentially placed into the corresponding placement slots through the notch. After the placement of the container is completed, the placement plate pulled out of the cavity 201 can be reset. S2. After the storage plate 200 is reset, the staff rotates the uppermost knob 230, and the threaded rod 740 is driven to rotate by the knob 230, so that the threaded rod 740 drives the threaded block 741 to move. The threaded block 741 drives the two pressing plates 742 to move. The movement of the two pressing plates 742 can press the corresponding moving plate 721, so that the moving plate 721 can drive the positioning rod 710 to move through the first mounting plate 720. The positioning rod 710 drives the second mounting plate 702 to move, and the second mounting plate 702 drives the positioning block 700 to move, so that the insertion rod 701 on the positioning block 700 abuts against the insertion plate 220. At this time, the storage plate 200 can be driven to move upward. When the storage plate 200 moves upward, the matching block 210 presses the extrusion block 510, so that the first clamping plate 610 and the second clamping plate 621 can clamp and fix the container. At the same time, the limiting rod 410 on the clamping frame 620 is inserted into the limiting groove 301. When the storage plate 200 moves upward to an appropriate height, the third spring 820 pushes the insertion rod 701 to insert into the corresponding insertion hole through the insertion ring 800 to realize the positioning of the position of the storage plate 200 after moving upward. Then, place the containers in the corresponding placement slots in sequence from top to bottom through the above operations, and move the storage plate 200 to an appropriate height. S3. After the storage board 200 in the cavity 201 finishes moving upward, the staff closes the cavity 201 by rotating the cabinet door 110. When the cabinet door 110 closes the cavity 201, the fixed inclined plane squeezes the extrusion inclined plane, causing the convex rod 1210 to move downward into the circular groove 1302. The downward movement of the convex rod 1210 can drive the first fixed plate 1130 to move downward through the connecting rod 1121. The downward movement of the first fixed plate 1130 can drive the rack 1140 to move downward. The downward movement of the rack 1140 can drive a plurality of gears 1110 to rotate. The rotation of the gears 1110 drives the corresponding round rods 1100 to rotate, realizing that the rotation of the round rods 1100 drives the support plate 1101 to support the lower end of the storage board 200, so as to avoid the storage board 200 from tilting in the cavity 201. Then, turn the bolt 112 on the locking plate 111 and thread one end of the bolt 112 into the drying oven 100 to continuously close the cabinet door 110 to the cavity 201; S4. Finally, through the cooperation of the compressor and the condenser, the voriconazole in the cavity 201 can be frozen. When the voriconazole in the container is completely frozen, the cavity 201 is pumped by a vacuum pump, making the cavity 201 in a low-pressure environment. At this time, the completely frozen voriconazole begins to sublime, and the moisture in the voriconazole begins to be removed, realizing the freeze-drying of voriconazole. When the cavity 201 is in a low-pressure environment, the temperature in the cavity 201 is heated by a heating plate, so that the voriconazole in the container can be heated, so that the voriconazole in the container can be further sublimated, so as to better remove the moisture in the voriconazole. The sublimated moisture can be collected by the cold trap in the cavity 201; S5. After the voriconazole finishes freeze-drying, turn the bolt 112 out of the side wall of the drying oven 100, rotate the cabinet door 110 to release the closure of the cabinet door 110 to the cavity 201. Then, turn the lowermost knob 230. The knob 230 drives the threaded rod 740 to rotate. The threaded rod 740 drives the threaded block 741 to move towards the knob 230. At the same time, the fourth spring 760 pushes the insertion rod 701 on the positioning block 700 out of the insertion hole, releasing the positioning of the storage board 200, and moving the storage board 200 with the positioning released to the lowest position. When the storage board 200 moves downward, the matching block 210 will release the extrusion of the extrusion block 510, so that the first clamping plate 610 and the second clamping plate 621 release the clamping and fixing of the container. At the same time, the limiting rod 410 on the clamping frame 620 slides into the installation groove 601. When the storage board 200 moves down to the lowest position, pull the storage board 200 out of the cavity 201. At this time, the staff can take the container on the storage board 200. After taking it, reset the storage board 200. Then, repeat the above steps and operate from top to bottom to take the containers on other storage boards 200.

[0051] In summary, the above are only the preferred embodiments of the present invention, and all equivalent changes and modifications made according to the scope of the patent application of the present invention shall fall within the scope covered by the patent of the present invention.

Claims

1. A freeze-drying device for the preparation of voriconazole, comprising a drying box with a cavity inside, and a switchable cabinet door is also provided on the drying box, characterized in that: Inside the cavity, there are multiple movable storage plates arranged from top to bottom. An installation groove with an opening on one side is formed in each storage plate. Multiple placement grooves are formed on the lower side surface of the installation groove. Multiple notches communicating with the placement grooves are formed on the upper end surface of the storage plate. The container containing voriconazole is placed in the corresponding placement groove through the notch. A clamping component is arranged in the installation groove, and the upward movement of the storage plate is used to drive the clamping component to clamp and fix the container in the placement groove. A limiting component is also arranged in the installation groove. The clamping component is used to drive the limiting component to limit the storage plate in the cavity. A positioning component is also arranged in the installation groove. The upward movement of the storage plate is used to drive the positioning component to position the position of the storage plate after upward movement. A fixing groove with an opening on one side is formed on the cabinet door. A supporting component is arranged in the fixing groove. The closing of the cabinet door is used to drive the supporting component to support one end of the storage plate. A drying component is also arranged in the cavity. The drying component is used to freeze-dry the voriconazole in the container.

2. The freeze-drying device for preparing voriconazole according to claim 1, wherein: First clamping plates are arranged on the lower side surface of the installation groove and on one side of the placement groove. The clamping component includes multiple lifting plates arranged in the cavity. The lifting plates are arranged to be liftable. One end of a clamping frame that can move is arranged on each lifting plate and extends into the corresponding installation groove. Multiple second clamping plates are arranged on the clamping frame. The second clamping plates are all located on the other side of the corresponding placement groove. The clamping frame drives the multiple second clamping plates to move towards the corresponding first clamping plates to clamp and fix the container in the placement groove. Multiple driving components are also arranged in the cavity. The driving components are used to drive the upward-moving clamping frame to move.

3. A freeze-drying device for preparing voriconazole according to claim 2, characterized in that: A through groove penetrating the storage plate is formed on one side wall of the installation groove along its length direction. A through plate with one end extending out of the through groove is arranged on the clamping frame. An extrusion block is arranged on the extending end of the through plate. A first inclined surface is formed on the extrusion block. The driving component includes multiple matching blocks arranged on the side wall of the cavity. A second inclined surface matching with the corresponding first inclined surface is formed on each matching block. When the storage plate drives the clamping frame to move upward, the second inclined surface on the matching block extrudes the first inclined surface to realize the movement of the clamping frame.

4. A freeze-drying device for the preparation of voriconazole according to claim 3, characterized in that: A vertical plate is arranged on the lifting plate. A through rod with one end penetrating the vertical plate is arranged on the clamping frame. A through ring is sleeved on the through rod. A first spring is sleeved on the through rod between the through ring and the vertical plate. The first spring is used to push the through ring away from the vertical plate.

5. A freeze-drying device for preparing voriconazole according to claim 4, characterized in that: A limiting plate is arranged in the cavity. A vertical limiting groove is formed on the limiting plate. The limiting component includes a limiting rod arranged on the clamping frame. The movement of the clamping frame is used to drive one end of the limiting rod to penetrate the storage plate and insert into the limiting groove to realize that the limiting rod limits the storage plate in the cavity.

6. A freeze-drying device for preparing voriconazole according to claim 5, characterized in that: Opposite inserting plates are arranged in the cavity. Multiple inserting holes are formed on each inserting plate. The positioning component includes opposite positioning blocks arranged on the lower end surface of the storage plate. The positioning blocks are arranged to be movable. Telescopic inserting rods are arranged on each positioning block. A moving component is arranged on the storage plate between the two positioning blocks. The moving component is used to drive the two positioning blocks to move away from each other. The upward movement of the storage plate is used to drive the inserting rods on the positioning blocks to insert into the corresponding inserting holes to realize the positioning of the position of the storage plate after upward movement.

7. A freeze-drying device for preparing voriconazole according to claim 6, characterized in that: On the lower end surface of the storage plate, there are opposite first mounting plates. Moving plates are provided on the first mounting plates. Third inclined surfaces are formed on the moving plates. On the lower end surface of the storage plate and on both sides, there are opposite supports. Second mounting plates are provided on the positioning blocks. Positioning rods that are opposite and penetrate through the two supports are provided on the second mounting plates. The penetrating ends of the two positioning rods are connected to the corresponding first mounting plates; The moving member includes a rotatable threaded rod provided on the lower end surface of the storage plate. A rotatable threaded block is sleeved on the threaded rod. Extrusion plates are provided on both sides of the threaded block. Fourth inclined surfaces that cooperate with the corresponding third inclined surfaces are formed at one end of each extrusion plate. When the threaded rod rotates, it drives the fourth inclined surfaces on the extrusion plates to extrude the corresponding third inclined surfaces, so as to realize the mutual separation of the two positioning blocks.

8. A freeze-drying device for preparing voriconazole according to claim 7, characterized in that: The support assembly includes a plurality of round rods provided in the fixed groove. The round rods are rotatably arranged. A plurality of support plates are sleeved on the round rods. When the round rods rotate, the support plates are driven to abut against the lower end surface of the corresponding storage plate, so as to realize the support of the storage plate. A rotating member is also provided in the fixed groove. When the cabinet door is closed, the rotating member drives the round rods to rotate.

9. A freeze-drying device for preparing voriconazole according to claim 8, characterized in that: There is a fixed block on the drying box. A fixed inclined surface is formed on the fixed block. A round hole communicating with the fixed groove is formed on the upper end surface of the cabinet door. A circular groove is formed on the cabinet door at the position of the round hole. Gears are sleeved on the round rods. Opposite fixed rods are provided in the fixed groove. A first fixing plate and a second fixing plate are provided in the fixed groove. Both ends of the first fixing plate and the second fixing plate are sleeved on the corresponding fixed rods. A second spring is sleeved on the fixed rod below the second fixing plate. A rack that meshes with a plurality of gears is provided between the first fixing plate and the second fixing plate; The rotating member includes a connecting rod provided on the second fixing plate and having one end passing through the round hole and the circular groove. A convex rod is provided at the protruding end of the connecting rod. An extrusion inclined surface that cooperates with the fixed inclined surface is formed on the convex rod. When the cabinet door is closed, the fixed inclined surface is driven to extrude the extrusion inclined surface, so as to realize the rotation of the round rod.

10. A voriconazole freeze-drying method, characterized in that: Adopt a freeze-drying device for preparing voriconazole according to any one of claims 1-9, which specifically includes the following steps: S1. First, open the cabinet door, and move the storage plate in the cavity to the lowest position. Then, pull the uppermost storage plate a certain distance towards the opening of the cavity. At this time, place the container containing voriconazole on the uppermost storage plate and place it in the corresponding placement groove through the notch. Then, reset the pulled storage plate; After the storage plate is reset, the staff needs to drive the positioning assembly. After the positioning assembly is driven, the staff moves the storage plate upward. When the storage plate moves upward, it can drive the clamping assembly. At this time, the clamping assembly in the installation groove can clamp and fix the container in the placement groove. At the same time, the clamping assembly drives the limiting assembly to limit the storage plate, so that the storage plate can only move up and down in the cavity. When the storage plate moves up to an appropriate height, the positioning assembly automatically positions the position of the storage plate. Then, place the containers in the corresponding placement grooves in sequence from top to bottom through the above steps, and move the storage plate up to an appropriate height; S3. After the storage board in the cavity has moved upward, when the staff closes the cavity through the cabinet door, the cabinet door can drive the support assembly. After the cabinet door closes the cavity, the support assembly can support one end of the storage board to prevent the storage board from tilting in the cavity; S4. Finally, the voriconazole in the cavity can be freeze-dried through the drying assembly; S5. After the voriconazole has been freeze-dried, open the cabinet door. At this time, the staff needs to release the positioning of the lowermost storage board by the positioning assembly. Then, move the lowermost storage board down to the lowest position. At the same time, the clamping assembly releases the clamping of the container, and the clamping assembly also drives the limiting assembly to release the limitation of the storage board. At this time, the staff can pull the lowermost storage board out of the cavity so that the staff can take the container on the storage board. After taking it, reset the storage board. Then, repeat the above steps and operate from top to bottom to take the containers on other storage boards.

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