A device and method for separating active substances from yak milk

Abstract

This invention relates to the field of yak milk processing technology, and discloses a device and method for separating active substances from yak milk, comprising: a first separation unit, a first processing unit, a pH adjustment unit, a second separation unit, and a third separation unit connected in sequence; the first separation unit is used for centrifugation of yak milk to obtain skimmed yak milk; the first processing unit is used for defoaming the skimmed yak milk; the second separation unit is used for centrifugation of the pH-adjusted skimmed yak milk to obtain supernatant and casein; the third separation unit is used for chromatographic separation of the supernatant to obtain lactoferrin and immunoglobulins. The defoaming treatment of the skimmed yak milk in the first processing unit effectively eliminates air bubbles in the skimmed milk, preventing air bubbles from occupying space and hindering the full contact between the acid solution and the skimmed yak milk, preventing local pH unevenness, improving the mixing effect of the skimmed yak milk and acid solution, increasing the casein yield, and ensuring the subsequent separation effect.

Description

Technical Field

[0001] This invention relates to the field of yak milk processing technology, and more specifically, to a device and method for separating active substances from yak milk. Background Technology

[0002] Yak milk contains abundant bioactive substances, such as casein, lactoferrin, and immunoglobulins. To separate these bioactive substances, the fat must first be removed to obtain skim yak milk. Then, casein and whey protein (the supernatant) are separated. The whey protein (supernatant) contains lactoferrin and immunoglobulins. The effectiveness of casein separation affects the yield of whey protein, which in turn affects the yield of lactoferrin and immunoglobulins.

[0003] In existing technologies, the pH value of skim yak milk is usually adjusted before centrifugation to improve the casein yield. However, when adjusting the pH value, if the skim yak milk contains a large number of air bubbles, these air bubbles occupy a certain space and hinder the full contact between the acid solution and the skim yak milk, resulting in uneven local pH values. This prevents some casein from precipitating effectively and affects the subsequent separation effect.

[0004] Therefore, it is necessary to propose a device and method for separating active substances from yak milk, so as to at least partially solve the problems existing in the prior art. Summary of the Invention

[0005] The summary section introduces a series of simplified concepts, which will be further explained in detail in the detailed description section. This summary section is not intended to limit the key features and essential technical features of the claimed technical solution, nor is it intended to determine the scope of protection of the claimed technical solution.

[0006] To at least partially solve the above problems, the present invention provides a device for separating active substances in yak milk, comprising: a first separation section, a first processing section, a pH adjustment section, a second separation section, and a third separation section connected in sequence;

[0007] The first separation section is used to centrifuge yak milk to obtain skimmed yak milk;

[0008] The first processing unit is used to defoam skimmed yak milk;

[0009] The second separation section is used to centrifuge the skimmed yak milk after pH adjustment to obtain supernatant and casein;

[0010] The third separation section is used to perform chromatographic separation on the supernatant to obtain lactoferrin and immunoglobulins.

[0011] Preferably, it further includes a second processing unit connected between the pH adjustment unit and the second separation unit, for pre-cooling the skimmed yak milk after pH adjustment.

[0012] Preferably, the first processing unit includes:

[0013] The first housing has two ends connected to the first separation part and the pH adjustment part respectively via connecting pipes, and the first housing is provided with an exhaust port;

[0014] Multiple parallel exhaust branches are disposed within the first housing. The two ends of each exhaust branch are connected to a connecting pipe. The exhaust branches are used to remove air bubbles from the skim yak milk that has passed through them.

[0015] Preferably, the exhaust branch pipe includes:

[0016] The main body of the branch pipe has multiple defoaming chambers arranged at intervals on it. The inner diameter of the defoaming chambers is larger than the inner diameter of the main body of the branch pipe. The defoaming chambers can keep the bubbles in the skim yak milk on the top surface of the defoaming chambers and prevent them from continuing to flow forward with the skim yak milk.

[0017] A breathable membrane is placed on the top surface of the defoaming chamber to allow air bubbles in skim yak milk to pass through while preventing skim yak milk from passing through.

[0018] Preferably, it also includes:

[0019] The exhaust section is connected to the exhaust port on the first housing and is used to make the pressure inside the first housing less than the pressure inside the branch pipe body.

[0020] A first pressure sensor is installed on the first housing to detect the pressure inside the first housing;

[0021] The second pressure sensor is installed on the main body of the branch pipe or the connecting pipe to detect the pressure inside the main body of the branch pipe.

[0022] Preferably, the second processing unit includes:

[0023] The second housing is connected to the pH adjustment unit and the second separation unit at both ends via connecting pipes. The second housing is provided with a cooling medium inlet and a cooling medium outlet.

[0024] The precooling pipe is installed inside the second housing, and its two ends are connected to the connecting pipe respectively.

[0025] Preferably, the precooling tube is a spiral tube.

[0026] Preferably, the precooling pipe includes a plurality of parallel precooling branch pipes;

[0027] The precooling branch pipe includes: multiple flow-disrupting bodies connected in sequence, the middle part of the flow-disrupting body is a hollow part, the cross-section of the hollow part is a regular hexagon, and there are two flow channels on both sides of the hollow part inside the flow-disrupting body;

[0028] After the pH value of the skimmed yak milk is adjusted, it enters the main body of the turbulent flow and flows through the hollowed-out part into two channels, where it merges after passing through the hollowed-out part.

[0029] A method for separating active substances from yak milk, comprising:

[0030] The yak milk after impurities have been removed is centrifuged at a speed of 3000 r / min to 8000 r / min in the first separation section to obtain skimmed yak milk;

[0031] Skim yak milk is defoamed and its pH value is adjusted to 4.6-4.8. Then, it is centrifuged in the second separation section at a speed of 8000r / min-10000r / min to obtain supernatant and casein.

[0032] The supernatant was separated by chromatography using the third separation section to obtain lactoferrin and immunoglobulins.

[0033] Preferably, the skim yak milk is defoamed, including:

[0034] The skim yak milk is diverted and transported to multiple exhaust manifolds, causing the air bubbles in the skim yak milk to remain at the top of the defoaming chamber of the exhaust manifold, instead of continuing to flow forward with the skim yak milk. The air bubbles are then discharged through the permeable membrane at the top of the defoaming chamber.

[0035] Compared with the prior art, the present invention has at least the following beneficial effects:

[0036] The active substance separation device and method for yak milk described in this invention address the issue that air may be introduced into the yak milk during transportation, forming bubbles. While some bubbles are eliminated by the separation action of the first separation unit, bubbles will still be generated if air remains trapped in the centrifuged yak milk. Therefore, the first processing unit is needed to defoam the skimmed yak milk, effectively eliminating bubbles and preventing them from occupying space and hindering the full contact between the acid solution and the skimmed yak milk. This prevents uneven local pH values, improves the mixing effect of the skimmed yak milk and acid solution, further increases the casein yield, and ensures the subsequent separation effect.

[0037] The active substance separation device and method for yak milk described in this invention, other advantages, objectives and features of this invention will be partly apparent from the following description, and partly understood by those skilled in the art through study and practice of this invention. Attached Figure Description

[0038] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used in conjunction with embodiments of the invention to explain the invention and do not constitute a limitation thereof. In the drawings:

[0039] Figure 1 This is a schematic diagram of the active substance separation device in yak milk according to the present invention;

[0040] Figure 2 This is a schematic diagram of the first processing unit in the yak milk active substance separation device of the present invention;

[0041] Figure 3 This is a schematic diagram of skimmed yak milk containing air bubbles in the main body of the branch pipe in the yak milk active substance separation device of the present invention.

[0042] Figure 4 This is a schematic diagram of bubbles entering the defoaming chamber in the yak milk active substance separation device of the present invention.

[0043] Figure 5 This is a schematic diagram of the first embodiment of the precooling tube in the active substance separation device for yak milk according to the present invention;

[0044] Figure 6 This is a schematic diagram of the second embodiment of the precooling tube in the yak milk active substance separation device of the present invention. Detailed Implementation

[0045] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments, so that those skilled in the art can implement it based on the description.

[0046] It should be understood that terms such as “having,” “comprising,” and “including” as used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0047] like Figure 1 As shown, the present invention provides a device for separating active substances in yak milk, comprising: a first separation unit 1, a first processing unit 2, a pH adjustment unit, a second separation unit 3, and a third separation unit 4 connected in sequence;

[0048] The first separation unit 1 is used to centrifuge yak milk to obtain skimmed yak milk;

[0049] The first processing unit 2 is used to defoam skimmed yak milk;

[0050] The second separation section 3 is used to centrifuge the skimmed yak milk after pH adjustment to obtain supernatant and casein;

[0051] The supernatant is whey protein.

[0052] The third separation section 4 is used to perform chromatographic separation on the supernatant to obtain lactoferrin and immunoglobulins.

[0053] Furthermore, the pH adjustment unit includes an acid solution addition unit 5 employing a metering pump and a pH detector 6.

[0054] The first separation section 1 and the second separation section 3 can be disc separators or tubular separators, etc. When separating yak milk through the first separation section 1, the temperature is 4℃~8℃ and the rotation speed is 3000r / min~8000r / min. When separating skimmed yak milk after pH adjustment through the second separation section 3, the temperature is 4℃~8℃ and the rotation speed is 8000r / min~10000r / min.

[0055] The pH value of the skimmed yak milk is adjusted to 4.6-4.8 by the pH adjustment unit to ensure thorough mixing with the acid solution, causing casein to precipitate. The casein is then separated by centrifugation in the second separation unit 3 to obtain whey protein and casein. The acid solution can be lactic acid, citric acid, acetic acid, etc.

[0056] The third separation section 4 can use any of the existing chromatographic separation methods to separate lactoferrin and immunoglobulins, which will not be described in detail here;

[0057] Air may be introduced into yak milk during transportation, forming bubbles. The separation action of the first separation unit 1 will eliminate some of the bubbles. However, if air is trapped in the centrifuged yak milk, bubbles will still be generated. Therefore, the first processing unit 2 is needed to defoam the skimmed yak milk. This process effectively eliminates bubbles in the skimmed milk, preventing them from occupying space and hindering the full contact between the acid solution and the skimmed yak milk. This prevents uneven local pH values, improves the mixing effect of the skimmed yak milk and the acid solution, further increases the casein yield, and ensures the subsequent separation effect.

[0058] In one embodiment, it further includes a second processing unit 7 connected between the pH adjustment unit and the second separation unit 3, for pre-cooling the skimmed yak milk after pH adjustment.

[0059] Since the skimmed yak milk from the first separation section 1 still needs to pass through the first processing section 2 and the pH adjustment section (the temperature of mixing with the acid solution is not higher than 15°C to prevent protein denaturation), it will exchange heat with the external environment, resulting in a temperature increase. The temperature of the second separation section 3 during separation is 4°C to 8°C. Therefore, in order to shorten the time for the skimmed yak milk to decrease in temperature in the second separation section 3, it is pre-cooled before entering the second separation section 3. During the pre-cooling process, the acid solution can be fully mixed with the skimmed yak milk, so that the casein can be fully precipitated, thereby improving the separation effect and efficiency.

[0060] In one embodiment, the first processing unit 2 includes:

[0061] The first housing 21 is connected to the first separation part 1 and the pH adjustment part respectively through connecting pipes at both ends. The first housing 21 is provided with an exhaust port 22.

[0062] Multiple parallel exhaust branches 23 are disposed inside the first housing 21. The two ends of each exhaust branch 23 are connected to a connecting pipe. The exhaust branch 23 is used to remove air bubbles from the skim yak milk that has passed through it.

[0063] Skimmed yak milk is diverted from the connecting pipe into multiple exhaust branch pipes 23. The inner diameter of the exhaust branch pipes 23 is small, but there are many of them, so it does not affect the conveying speed of the skimmed yak milk. The sum of the cross-sectional areas of the multiple exhaust branch pipes 23 corresponds to the cross-sectional area of ​​the connecting pipe to ensure the conveying speed of the skimmed yak milk.

[0064] When skim yak milk passes through the exhaust branch pipe 23, it can expel air bubbles, and the gas is discharged to the outside from the exhaust port 22 of the first shell 21. After passing through multiple exhaust branch pipes 23, the skim yak milk flows together and flows from the connecting pipe to the pH adjustment section.

[0065] like Figure 2 As shown, the exhaust manifold 23 further includes:

[0066] The branch pipe body 231 has multiple defoaming chambers 232 arranged at intervals on it. The inner diameter of the defoaming chamber 232 is larger than the inner diameter of the branch pipe body 231. The defoaming chamber 232 can keep the bubbles in the skim yak milk on the top surface of the defoaming chamber 232 and prevent them from continuing to flow forward with the skim yak milk.

[0067] A breathable membrane 233 is disposed on the top surface of the defoaming chamber 232 to allow air bubbles in skim yak milk to pass through while preventing skim yak milk from passing through.

[0068] The top surface of the defoaming chamber 232 is set higher than the top surface of the branch pipe body 231, which makes it easier for bubbles to stay on the top surface of the defoaming chamber 232; a membrane with multiple holes can also be provided in the defoaming chamber 232, so that the bubbles are trapped above the membrane, while the skim yak milk can pass through the holes below, so as to further prevent the bubbles from continuing to flow forward with the skim milk.

[0069] The sum of the cross-sectional areas of the multiple branch pipe bodies 231 corresponds to the cross-sectional area of ​​the connecting pipe. The inner diameter of the defoaming chamber 232 is larger than the inner diameter of the branch pipe bodies 231, such as... Figure 3 As shown, when there are air bubbles in the skim yak milk being transported within the main body 231 of the branch pipe, the air bubbles enter the defoaming chamber 232. Since the air bubbles are lighter than the skim yak milk, they... Figure 4 As shown, the bubbles will come into contact with the top surface of the defoaming chamber 232. The top surface of the defoaming chamber 232 is provided with a breathable membrane 233. Under the squeezing action of the flow of skim yak milk on the bubbles, the gas inside the bubbles will be discharged from the breathable membrane 233, thus achieving the purpose of defoaming.

[0070] like Figure 2 As shown, in one embodiment, it further includes:

[0071] The air extraction section is connected to the exhaust port 22 on the first housing 21 and is used to make the pressure inside the first housing 21 less than the pressure inside the branch pipe body 231.

[0072] A first pressure sensor is installed on the first housing 21 to detect the pressure inside the first housing 21;

[0073] The second pressure sensor is installed on the branch pipe body 231 or the connecting pipe to detect the pressure inside the branch pipe body 231.

[0074] Based on the aforementioned embodiments, this embodiment adds an air extraction section to make the pressure inside the first housing 21 less than the pressure inside the branch pipe body 231, thereby causing bubbles to be discharged from the breathable membrane 233 and improving defoaming efficiency. The first pressure sensor and the second pressure sensor can monitor the pressure changes inside the first housing 21 and the branch pipe body 231 in real time, thereby controlling the operation of the air extraction section, that is, to extract air from the first housing 21 so that the pressure inside it is less than the pressure inside the branch pipe body 231. In this way, the bubbles in the defoaming chamber 232 can be discharged from the breathable membrane 233 under the squeezing action of the flowing skim yak milk.

[0075] In this embodiment, the air extraction unit does not need to work continuously. As long as the pressure inside the first housing 21 is less than the pressure inside the branch pipe body 231, air extraction is not required.

[0076] like Figure 5 and Figure 6 As shown, in one embodiment, the second processing unit 7 includes:

[0077] The second housing 71 is connected to the pH adjustment part and the second separation part 3 respectively through connecting pipes at both ends. The second housing 71 is provided with a cooling medium inlet 72 and a cooling medium outlet 73.

[0078] The precooling pipe is installed inside the second housing 71, and its two ends are connected to the connecting pipe respectively.

[0079] The cooling medium inlet 72 and the cooling medium outlet 73 are connected to the cooling medium circulation section, which is used for the circulation and heat exchange of the cooling medium to ensure that the cooling medium entering the second shell 71 can exchange heat with the pre-cooling pipe, thereby ensuring that the temperature of the skimmed yak milk inside the pre-cooling pipe is maintained at a set temperature (e.g., 4℃~8℃). The skimmed yak milk with added acid solution enters the pre-cooling pipe through the connecting pipe, exchanges heat with the cooling medium in the second shell 71 while flowing in the pre-cooling pipe, and then is discharged from the pre-cooling pipe.

[0080] like Figure 5 As shown, in one embodiment, the precooling tube is a spiral tube 74.

[0081] This embodiment is the first design of the precooling tube. The precooling tube is spiral-shaped, which can increase the contact time between skim yak milk and the cooling medium. At the same time, the skim yak milk can also be fully mixed with the acid solution in the precooling tube to promote casein precipitation.

[0082] like Figure 6 As shown, in one embodiment, the precooling pipe includes a plurality of parallel precooling branch pipes 75;

[0083] The precooling branch pipe 75 includes: a plurality of sequentially connected flow-disrupting bodies 751, the middle part of which is a hollow part 752, the cross-section of which is a regular hexagon, and two flow channels located on both sides of the hollow part 752 inside the flow-disrupting body 751.

[0084] After the pH value of the skimmed yak milk is adjusted, it enters the turbulence body 751 and is diverted into two channels by the hollow part 752, and then converges after passing through the hollow part 752.

[0085] This embodiment is the second scheme of the precooling pipe. The precooling pipe consists of multiple precooling branch pipes 75. By utilizing the hollow part 752 of the turbulence body 751, the skim yak milk with added acid solution is diverted into two flow channels and then merged before entering the next turbulence body 751. This process of diversion and merging multiple times can promote the full mixing of acid solution and skim yak milk. In addition, the air bubbles in the skim yak milk have been removed, and the air bubbles will not occupy space and affect the contact between acid solution and skim yak milk.

[0086] Since the middle part of the turbulence-disrupting body 751 is a hollow part 752, and multiple pre-cooling branch pipes 75 are arranged in parallel at intervals, the cooling medium in the second shell 71 can flow between adjacent pre-cooling branch pipes 75 and at the hollow part 752, and fully exchange heat with the pre-cooling branch pipes 75, thereby improving the heat exchange efficiency.

[0087] The precooling pipe is preferably installed vertically. If the precooling pipe is installed horizontally, the precooling pipe and the connecting pipe can be sealed and rotated. The rotational connection position of the two is outside the second housing 71. The rotation of the precooling pipe is controlled by the drive unit to prevent casein deposition at the bottom of the horizontally installed precooling pipe and prevent blockage.

[0088] This invention also provides a method for separating active substances from yak milk, comprising:

[0089] The yak milk after impurities have been removed is centrifuged at a speed of 3000 r / min to 8000 r / min in the first separation section 1 to obtain skimmed yak milk.

[0090] Skim yak milk is defoamed and its pH value is adjusted to 4.6-4.8. Then, it is centrifuged in the second separation section 3 at a speed of 8000r / min-10000r / min to obtain supernatant and casein.

[0091] The supernatant was separated by chromatography using the third separation section 4 to obtain lactoferrin and immunoglobulins.

[0092] The first separation section 1 and the second separation section 3 can be disc separators or tubular separators, etc. When separating yak milk through the first separation section 1, the temperature is 4℃~8℃ and the rotation speed is 3000r / min~8000r / min. When separating skimmed yak milk after pH adjustment through the second separation section 3, the temperature is 4℃~8℃ and the rotation speed is 8000r / min~10000r / min.

[0093] The pH value of the skimmed yak milk is adjusted to 4.6-4.8 by the pH adjustment unit to ensure thorough mixing with the acid solution, causing casein to precipitate. The casein is then separated by centrifugation in the second separation unit 3 to obtain whey protein and casein. The acid solution can be lactic acid, citric acid, acetic acid, etc.

[0094] Air may be introduced into yak milk during transportation, forming bubbles. The separation action of the first separation section 1 will eliminate some of these bubbles. However, if air is trapped in the centrifuged yak milk, bubbles will still be generated. Therefore, defoaming treatment of skim yak milk is necessary. This effectively eliminates bubbles in skim yak milk, preventing them from occupying space and hindering the full contact between the acid solution and the skim yak milk. This prevents uneven local pH values, improves the mixing effect of skim yak milk and acid solution, further increases the casein yield, and ensures the subsequent separation effect.

[0095] In one embodiment, defoaming treatment of skim yak milk includes:

[0096] The skim yak milk is diverted and transported to multiple exhaust branches 23, so that the air bubbles in the skim yak milk remain at the top of the defoaming chamber 232 of the exhaust branch 23 and do not continue to flow forward with the skim yak milk. The air bubbles are discharged through the breathable membrane 233 at the top of the defoaming chamber 232.

[0097] Skimmed yak milk is diverted from the connecting pipe into multiple exhaust branch pipes 23. The inner diameter of the exhaust branch pipes 23 is small, but there are many of them, so it does not affect the conveying speed of the skimmed yak milk. The sum of the cross-sectional areas of the multiple exhaust branch pipes 23 corresponds to the cross-sectional area of ​​the connecting pipe to ensure the conveying speed of the skimmed yak milk.

[0098] When there are air bubbles in the skim yak milk being transported, the air bubbles enter the defoaming chamber 232. Because the air bubbles are lighter than the skim yak milk, ... Figure 4 As shown, the bubbles will come into contact with the top surface of the defoaming chamber 232. The top surface of the defoaming chamber 232 is provided with a breathable membrane 233. Under the squeezing action of the flow of skim yak milk on the bubbles, the gas inside the bubbles will be discharged from the breathable membrane 233, thus achieving the purpose of defoaming.

[0099] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this invention and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0100] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between them; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0101] Although the embodiments of the present invention have been disclosed above, they are not limited to the applications listed in the specification and embodiments. They can be applied to various fields suitable for the present invention. For those skilled in the art, other modifications can be easily made. Therefore, without departing from the general concept defined by the present invention, the present invention is not limited to the specific details and illustrations shown and described herein.

Claims

1. A device for separating active substances from yak milk, characterized in that, include: The first separation unit (1), the first processing unit (2), the pH adjustment unit, the second separation unit (3), and the third separation unit (4) are connected in sequence. The first separation section (1) is used to centrifuge yak milk to obtain skimmed yak milk; The first processing unit (2) is used to defoam skimmed yak milk; The second separation section (3) is used to centrifuge the skimmed yak milk after pH adjustment to obtain supernatant and casein; The third separation section (4) is used to perform chromatographic separation of the supernatant to obtain lactoferrin and immunoglobulins; The first processing unit (2) includes: The first housing (21) is connected to the first separation part (1) and the pH adjustment part respectively through connecting pipes at both ends. The first housing (21) is provided with an exhaust port (22). Multiple parallel exhaust branch pipes (23) are disposed inside the first housing (21). The two ends of the exhaust branch pipes (23) are respectively connected to the connecting pipes. The exhaust branch pipes (23) are used to remove air bubbles from the skim yak milk that has passed through. The exhaust branch pipe (23) includes: The main body of the branch pipe (231) has multiple defoaming cavities (232) arranged at intervals on it. The inner diameter of the defoaming cavity (232) is larger than the inner diameter of the main body of the branch pipe (231). The defoaming cavity (232) can keep the bubbles in the skim yak milk on the top surface of the defoaming cavity (232) and prevent them from continuing to flow forward with the skim yak milk. A breathable membrane (233) is disposed on the top surface of the defoaming chamber (232) to allow air bubbles in skim yak milk to pass through and to prevent skim yak milk from passing through.

2. The device for separating active substances in yak milk according to claim 1, characterized in that, Also includes: The second processing unit (7), connected between the pH adjustment unit and the second separation unit (3), is used to pre-cool the skimmed yak milk after pH adjustment.

3. The device for separating active substances in yak milk according to claim 1, characterized in that, Also includes: The air extraction section is connected to the exhaust port (22) on the first housing (21) and is used to make the pressure inside the first housing (21) less than the pressure inside the branch pipe body (231); A first pressure sensor is disposed on the first housing (21) for detecting the pressure inside the first housing (21); The second pressure sensor is installed on the branch pipe body (231) or the connecting pipe to detect the pressure inside the branch pipe body (231).

4. The device for separating active substances in yak milk according to claim 2, characterized in that, The second processing unit (7) includes: The second housing (71) is connected to the pH adjustment unit and the second separation unit (3) at both ends by connecting pipes. The second housing (71) is provided with a cooling medium inlet (72) and a cooling medium outlet (73). The precooling pipe is installed in the second housing (71), and its two ends are connected to the connecting pipe respectively.

5. The device for separating active substances in yak milk according to claim 4, characterized in that, The precooling tube is a spiral tube (74).

6. The device for separating active substances in yak milk according to claim 4, characterized in that, The precooling pipe includes multiple parallel precooling branch pipes (75); The precooling branch pipe (75) includes: a plurality of sequentially connected turbulence-disrupting bodies (751), the middle part of the turbulence-disrupting body (751) is a hollow part (752), the cross-section of the hollow part (752) is a regular hexagon, and there are two flow channels inside the turbulence-disrupting body (751) located on both sides of the hollow part (752); After the pH value is adjusted, the skimmed yak milk enters the turbulence body (751) and is diverted to two channels by the hollow part (752), and then merges after passing through the hollow part (752).

7. A method for separating active substances from yak milk, comprising using the yak milk active substance separation device according to any one of claims 1-6, characterized in that, include: The yak milk after removing impurities is centrifuged at a speed of 3000 r / min to 8000 r / min using the first separation section (1) to obtain skimmed yak milk; The skimmed yak milk was defoamed and its pH was adjusted to 4.6-4.

8. Then, it was centrifuged in the second separation section (3) at a speed of 8000r / min-10000r / min to obtain the supernatant and casein. The supernatant was separated by chromatography using the third separation section (4) to obtain lactoferrin and immunoglobulins.

8. The method for separating active substances from yak milk according to claim 7, characterized in that, Defoaming treatment of skim yak milk includes: The skimmed yak milk is diverted and transported to multiple exhaust branches (23), so that the bubbles in the skimmed yak milk remain at the top of the defoaming chamber (232) of the exhaust branch (23) and do not continue to flow forward with the skimmed yak milk. The bubbles are discharged through the breathable membrane (233) at the top of the defoaming chamber (232).

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