Low-pressure high-low-oxygen animal intelligent environment simulation cabin adopting Freon for refrigeration

Abstract

The invention discloses a low-pressure high-oxygen and low-oxygen animal intelligent environment simulation cabin adopting Freon for refrigeration, and belongs to the technical field of intelligent environment simulation cabins, the low-pressure high-oxygen and low-oxygen animal intelligent environment simulation cabin comprises a storage cabin, an experiment cabin is mounted at the top end of the storage cabin and is a sealed cabin body, a sealed cabin door is rotatably arranged on one side of the experiment cabin, and sliding rails are symmetrically arranged on the inner wall of the experiment cabin; an animal carrying plate is arranged between the two sliding rails in a sliding mode, an air conditioner outdoor unit and a vacuum pump are installed in the storage cabin, an air conditioner indoor unit is installed in the experiment cabin, the air conditioner outdoor unit and the air conditioner indoor unit are connected through a pipeline to form a temperature adjusting system, the vacuum pump and the experiment cabin are connected through a pipeline to form a pressure adjusting system, and a central controller is installed in the storage cabin. And the central controller is electrically connected with the temperature regulating system and the voltage regulating system. The temperature adjusting system adopts Freon for refrigeration, compared with traditional water cooling or semiconductor refrigeration, the effect is better, the temperature in the experiment cabin can be effectively maintained at a proper level, the problem of excessive water vapor is avoided, and the accuracy of experiment data is ensured.

Description

Technical Field

[0001] The present invention belongs to the technical field of intelligent environmental simulation chambers, and particularly relates to a low-pressure high-low oxygen animal intelligent environmental simulation chamber using Freon refrigeration. Background Art

[0002] The core principle of the low-pressure high-low oxygen animal intelligent environmental simulation chamber is to simulate the staged hypoxia OSA model of the plateau or special hypoxic environment by precisely controlling the air pressure, oxygen concentration, and environmental parameters, so as to study the physiological, pathological reactions, and adaptive mechanisms of animals under hypoxic conditions.

[0003] Traditional refrigeration technologies in the low-pressure high-low oxygen animal intelligent environmental simulation chamber generally use water cooling or semiconductor refrigeration. However, the cooling capacity of water cooling or semiconductor refrigeration is often limited and difficult to meet the requirements. When there are many animals in the chamber, their respiratory metabolism will release a large amount of heat, causing the temperature in the chamber to rise. In this case, a large amount of water vapor will appear on the chamber wall, similar to the phenomenon of fogging on the indoor window in winter, which will interfere with the experiment. In order to change this situation and reduce the interference caused by the increase in water vapor and humidity, the present invention proposes a low-pressure high-low oxygen animal intelligent environmental simulation chamber using Freon refrigeration to solve the deficiencies in the prior art. Summary of the Invention

[0004] The purpose of the present invention is to provide a low-pressure high-low oxygen animal intelligent environmental simulation chamber using Freon refrigeration, which changes the traditional water cooling or semiconductor refrigeration method, greatly reduces the increase in humidity in the chamber caused by the increase in water vapor, and further reduces the interference of this situation on the experiment.

[0005] To achieve the above-mentioned invention purpose, the technical solution adopted by the present invention is as follows:

[0006] A low-pressure high-low oxygen animal intelligent environmental simulation chamber using Freon refrigeration, comprising: a storage chamber, an experimental chamber is installed at the top of the storage chamber, the experimental chamber is a sealed chamber body, a sealed chamber door is rotatably arranged on one side of the experimental chamber, slide rails are symmetrically arranged on the inner wall of the experimental chamber, an animal carrier plate is slidably arranged between the two slide rails, an air conditioner outdoor unit and a vacuum pump are installed inside the storage chamber, an air conditioner indoor unit is installed inside the experimental chamber, the air conditioner outdoor unit and the air conditioner indoor unit are connected by pipelines to form a temperature control system, the vacuum pump and the experimental chamber are connected by pipelines to form a pressure control system, a central controller is installed inside the storage chamber, and the central controller is electrically connected to the temperature control system and the pressure control system.

[0007] Further, a sensor module is installed inside the experimental chamber, the sensor module is electrically connected to the central controller, and the sensor module includes: a temperature sensor, a humidity sensor, an oxygen concentration sensor, a carbon dioxide concentration sensor, and a pressure sensor.

[0008] Further, the outdoor unit of the air conditioner includes a condenser and a compressor, and the indoor unit of the air conditioner includes an evaporator and a blower. The blower is installed on one side of the evaporator. The liquid outlet pipe of the evaporator is connected to the liquid inlet pipe of the compressor. The liquid outlet pipe of the compressor is connected to the liquid inlet pipe of the condenser. The liquid outlet pipe of the condenser is connected to the liquid inlet pipe of the evaporator to form a refrigerant circulation loop, and the refrigerant is freon.

[0009] Further, one end of the experimental chamber is provided with an oxygen inlet and a nitrogen inlet. The oxygen inlet and the nitrogen inlet are connected to an external gas source through an explosion-proof pipeline. Gas buffers are installed on both the oxygen inlet and the nitrogen inlet. The gas buffer is used to reduce the impact of the air flow on the animals.

[0010] Further, a fresh air circulation system is also installed inside the experimental chamber. The fresh air circulation system is electrically connected to the central controller. The fresh air circulation system is used to prevent the accumulation of carbon dioxide.

[0011] Further, an emergency exhaust valve and a leakage protector are installed on the cabin wall of the experimental chamber.

[0012] Further, a touch panel is installed on the cabin wall of the storage chamber. The touch panel is electrically connected to the central controller.

[0013] Further, casters with brakes are installed at the bottom end of the storage chamber.

[0014] Further, the experimental chamber is made of a transparent material.

[0015] A low-pressure, high-low oxygen animal intelligent environment simulation chamber using freon refrigeration provided by the present invention has the following advantages compared with the prior art:

[0016] The temperature control system of the present invention uses freon refrigeration, which has a better refrigeration effect than traditional water cooling or semiconductor refrigeration. It can effectively maintain the temperature inside the experimental chamber at an appropriate level, thereby avoiding the problem of excessive water vapor and ensuring the accuracy of experimental data. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only the embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained according to the provided drawings without creative efforts.

[0018] Figure 1 is a three-dimensional view of the present invention Figure I ;

[0019] Figure 2 is a three-dimensional view of the present inventionFigure II ;

[0020] Figure 3 This is a schematic structural diagram of the temperature control system of the present invention.

[0021] In the figure: 1 - storage cabin, 2 - experimental cabin, 3 - animal carrier plate, 4 - outdoor air conditioner unit, 5 - indoor air conditioner unit, 6 - condenser, 7 - compressor, 8 - evaporator, 9 - fan, 10 - oxygen inlet, 11 - nitrogen inlet, 12 - fresh air circulation system, 13 - emergency exhaust valve, 14 - touch panel, 15 - caster wheel brake. Specific embodiments

[0022] The technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and embodiments:

[0023] Refer to Figures 1-3 As shown, the present invention provides a low-pressure high-low oxygen animal intelligent environment simulation cabin using Freon refrigeration, including: a storage cabin 1, on the top of the storage cabin 1 is installed an experimental cabin 2, the experimental cabin 2 is a sealed cabin body, maintaining a low-pressure and low-oxygen environment through a sealed design while avoiding external interference. A sealed cabin door is rotatably arranged on one side of the experimental cabin 2, slide rails are symmetrically arranged on the inner wall of the experimental cabin 2, and an animal carrier plate 3 is slidably arranged between the two slide rails. An outdoor air conditioner unit 4 and a vacuum pump are installed inside the storage cabin 1, and an indoor air conditioner unit 5 is installed inside the experimental cabin 2. The outdoor air conditioner unit 4 and the indoor air conditioner unit 5 are connected by pipelines to form a temperature control system, and the vacuum pump and the experimental cabin 2 are connected by pipelines to form a pressure regulation system. The vacuum pump is used to reduce the pressure inside the experimental cabin 2 and cooperate with the gas source to simulate a low-pressure environment. A central controller is installed inside the storage cabin 1, and the central controller is electrically connected to the temperature control system and the pressure regulation system.

[0024] As a preferred embodiment, a sensor module is installed inside the experimental cabin 2, the sensor module is electrically connected to the central controller, and the sensor module includes: a temperature sensor, a humidity sensor, an oxygen concentration sensor, a carbon dioxide concentration sensor, and a pressure sensor. The sensor module is used to ensure the stability of environmental parameters and the accuracy of experimental data, and provide real-time curves and historical data records. The data of each sensor is transmitted to the central controller in real time, and the gas flow and pressure are adjusted through the PID algorithm to form a closed-loop control.

[0025] As a preferred embodiment, the outdoor air conditioner unit 4 includes: a condenser 6 and a compressor 7, the indoor air conditioner unit 5 includes: an evaporator 8 and a fan 9, the fan 9 is installed on one side of the evaporator 8, the liquid outlet pipe of the evaporator 8 is connected to the liquid inlet pipe of the compressor 7, the liquid outlet pipe of the compressor 7 is connected to the liquid inlet pipe of the condenser 6, and the liquid outlet pipe of the condenser 6 is connected to the liquid inlet pipe of the evaporator 8 to form a refrigerant circulation loop, and the refrigerant is Freon.

[0026] As a preferred embodiment, an oxygen inlet 10 and a nitrogen inlet 11 are provided at one end of the experimental chamber 2. The oxygen inlet 10 and the nitrogen inlet 11 are connected to an external gas source through explosion-proof pipelines. Gas buffers are installed on both the oxygen inlet 10 and the nitrogen inlet 11. The gas buffers are used to reduce the impact of air flow on animals. The oxygen concentration and pressure in the experimental chamber 2 are adjusted through the oxygen inlet 10 and the nitrogen inlet 11 to simulate a low-pressure and low-oxygen environment at different altitudes (up to 12,000 meters).

[0027] As a preferred embodiment, a fresh air circulation system 12 is further installed inside the experimental chamber 2. The fresh air circulation system 12 is electrically connected to the central controller. The fresh air circulation system 12 is used to prevent the accumulation of carbon dioxide.

[0028] As a preferred embodiment, an emergency exhaust valve 13 and a leakage protector are installed on the wall of the experimental chamber 2. The emergency exhaust valve 13 is activated in case of an abnormality (such as excessive oxygen concentration or abnormal pressure) to quickly restore normal pressure. The leakage protector is used to ensure the safety of experimental personnel and animals and prevent equipment damage or experiment interruption.

[0029] As a preferred embodiment, a touch panel 14 is installed on the wall of the storage chamber 1. The touch panel 14 is electrically connected to the central controller.

[0030] As a preferred embodiment, a caster brake 15 is installed at the bottom end of the storage chamber 1.

[0031] As a preferred embodiment, the experimental chamber 2 is made of a transparent material, such as acrylic. It is convenient to observe experimental animals. The size of the experimental chamber 2 is generally 600L (such as 1300mm×680mm×680mm), and it can accommodate 4 rat cages or 8 mouse cages.

[0032] The working principle of the present invention is as follows: 1. Synergistic control of air pressure and oxygen concentration Low-pressure simulation: The air pressure in the experimental chamber 2 is reduced by a vacuum pump to simulate a low-pressure environment at different altitudes (such as 70 kPa corresponding to an altitude of 3000 meters). The air pressure control needs to be synchronized with the oxygen concentration adjustment to avoid the imbalance of oxygen partial pressure caused by simple pressure reduction.

[0033] Formula: PO2 = Ptotal × FO2 (Oxygen partial pressure = total air pressure × volume fraction of oxygen gas) High and low oxygen adjustment: Low-oxygen mode: Inject nitrogen (N2) to dilute oxygen and reduce the oxygen concentration (such as 10% - 16%) to simulate low oxygen in the plateau.

[0034] High-oxygen mode (optional): Supplement pure oxygen (O2) to increase the oxygen concentration for comparative experiments or special research.

[0035] Dynamic adjustment: Through the oxygen inlet 10, nitrogen inlet 11, oxygen concentration sensor and central controller, the O2 / N2 ratio is adjusted in real time to maintain the stability of the target oxygen concentration.

[0036] 2. Maintenance of environmental parameter stability Temperature and humidity control: Use a temperature control system and a humidification / dehumidification device to maintain the temperature (20 - 25 °C) and humidity (40 - 60%) inside the chamber to avoid environmental fluctuations interfering with the experimental results.

[0037] CO2 removal: The carbon dioxide produced by animal respiration is removed through the fresh air circulation system 12 to prevent the accumulation of CO2 from affecting the calculation of oxygen partial pressure.

[0038] Airflow circulation: An internal fan or a flow guiding design is used to ensure uniform distribution of the gas inside the chamber and avoid local oxygen concentration differences.

[0039] 3. Intelligent monitoring and feedback system Sensor module: Real-time monitoring of parameters such as air pressure, oxygen concentration, temperature and humidity, CO2 concentration, etc., and the data is synchronously transmitted to the central controller.

[0040] Closed-loop feedback mechanism: Automatically adjust the gas input, vacuum pump power and environmental control equipment according to the sensor data to achieve dynamic balance.

[0041] Animal physiological monitoring (optional): Integrate biological signal acquisition modules such as heart rate, blood oxygen saturation, activity level, etc., and analyze the animal adaptation mechanism in association with environmental parameters.

[0042] 4. Principle of the combination of physiology and engineering Hypoxic stress response: The low-pressure and low-oxygen environment will activate the animal's hypoxia-inducible factor (HIF-1α), triggering compensatory responses such as polycythemia and angiogenesis. The experimental chamber 2 studies these mechanisms by precisely controlling the oxygen partial pressure.

[0043] Stepwise adaptation design: To avoid acute mountain sickness, the air pressure and oxygen concentration need to be gradually adjusted according to the experimental requirements (such as reducing the oxygen concentration by 5% per day), simulating the natural altitude increase process.

[0044] 5. Safety and redundancy design Emergency exhaust valve 13: When the oxygen concentration or air pressure exceeds the safety threshold, the emergency exhaust valve 13 is automatically opened to restore normal pressure.

[0045] Physical isolation and sealing: The experimental module 2 is made of pressure-resistant materials (such as aviation aluminum or reinforced glass), and the sealed design prevents gas leakage to ensure that the experimental environment is independent and controllable.

[0046] In the description of the present application, it should be noted that the orientation or positional relationship indicated by terms such as "upper" and "lower" is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation to the present application. Unless otherwise clearly specified and defined, the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0047] It should be noted that in the present application, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "including a..." does not exclude the existence of additional identical elements in the process, method, article or device including the said element.

[0048] The above is only the specific implementation manner of the present application, enabling those skilled in the art to understand or implement the present application. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to these embodiments shown herein, but will conform to the broadest scope consistent with the principles and novel features claimed herein.

Claims

1. A low-pressure high-low oxygen animal intelligent environment simulation chamber using Freon refrigeration, characterized in that, Including: A storage compartment (1), at the top of the storage compartment (1) is installed an experimental compartment (2), the experimental compartment (2) is a sealed cabin body, on one side of the experimental compartment (2) is rotatably provided with a sealed cabin door, on the inner wall of the experimental compartment (2) are symmetrically provided with slide rails, between the two slide rails is slidably provided an animal carrier plate (3), inside the storage compartment (1) are installed an air conditioner outdoor unit (4) and a vacuum pump, inside the experimental compartment (2) is installed an air conditioner indoor unit (5), the air conditioner outdoor unit (4) and the air conditioner indoor unit (5) are connected by pipelines to form a temperature control system, the vacuum pump and the experimental compartment (2) are connected by pipelines to form a pressure regulation system, inside the storage compartment (1) is installed a central controller, and the central controller is electrically connected to the temperature control system and the pressure regulation system.

2. An intelligent environmental simulation chamber for low-pressure and high-low oxygen animals using Freon refrigeration according to claim 1, characterized in that, Inside the experimental compartment (2) is installed a sensor module, the sensor module is electrically connected to the central controller, and the sensor module includes: a temperature sensor, a humidity sensor, an oxygen concentration sensor, a carbon dioxide concentration sensor, and a pressure sensor.

3. An intelligent environmental simulation chamber for low-pressure and high-low oxygen animals using Freon refrigeration according to claim 1, characterized in that, The air conditioner outdoor unit (4) includes: a condenser (6) and a compressor (7), the air conditioner indoor unit (5) includes: an evaporator (8) and a blower (9), the blower (9) is installed on one side of the evaporator (), the liquid outlet pipe of the evaporator (8) is connected to the liquid inlet pipe of the compressor (7), the liquid outlet pipe of the compressor (7) is connected to the liquid inlet pipe of the condenser (6), and the liquid outlet pipe of the condenser (6) is connected to the liquid inlet pipe of the evaporator (8) to form a refrigerant circulation loop, and the refrigerant is Freon.

4. An intelligent environmental simulation chamber for low-pressure and high-low oxygen animals using Freon refrigeration according to claim 1, characterized in that, At one end of the experimental compartment (2) are provided an oxygen inlet (10) and a nitrogen inlet (11), the oxygen inlet (10) and the nitrogen inlet (11) are connected to an external gas source through explosion-proof pipelines, and gas buffers are installed on both the oxygen inlet (10) and the nitrogen inlet (11), and the gas buffers are used to reduce the impact of the airflow on the animals.

5. An intelligent environmental simulation chamber for low-pressure and high-low oxygen animals using Freon refrigeration according to claim 1, characterized in that, Inside the experimental compartment (2) is also installed a fresh air circulation system (12), the fresh air circulation system (12) is electrically connected to the central controller, and the fresh air circulation system (12) is used to prevent carbon dioxide accumulation.

6. An intelligent environmental simulation chamber for low-pressure and high-low oxygen animals using Freon refrigeration according to claim 1, characterized in that, An emergency exhaust valve (13) and a leakage protector are installed on the cabin wall of the experimental compartment (2).

7. An intelligent environmental simulation chamber for low-pressure and high-low oxygen animals using Freon refrigeration according to claim 1, characterized in that A touch panel (14) is installed on the cabin wall of the storage compartment (1), and the touch panel (14) is electrically connected to the central controller.

8. An intelligent environmental simulation chamber for low-pressure and high-low oxygen animals using Freon refrigeration according to claim 1, characterized in that, Foot wheel brakes (15) are installed at the bottom of the storage compartment (1).

9. An intelligent environmental simulation chamber for low-pressure and high-low oxygen animals using Freon refrigeration according to claim 1, characterized in that, The experimental compartment (2) is made of a transparent material.

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