Local positioning hydrogel dressing and preparation method thereof

Abstract

The invention discloses a local positioning hydrogel dressing and a preparation method thereof, and relates to the technical field of dressings, the local positioning hydrogel dressing is technically characterized by comprising base cloth formed by blending lyocell fibers and viscose, a hydrogel layer formed by modified sodium polyacrylate hydrogel and an active component layer, and accurate nursing of different areas of the face can be achieved; the method has the advantages of good dry stability, low inactivation rate of active ingredients, accurate spatial positioning, high production efficiency and low environmental protection cost.

Description

Technical Field

[0001] The present invention relates to the technical field of dressings, and particularly to a local positioning hydrogel dressing and a preparation method thereof. Background Art

[0002] In the technical fields of cosmetics and medical dressings, traditional facial masks have various limitations. First of all, the entire facial mask substrate usually carries only a single active ingredient, which results in the inability of the facial mask to provide differential care for different areas of the face (such as the eye area, T-zone, nasolabial folds, etc.). This "one-size-fits-all" skin care method not only causes waste of resources, but also scatters the skin care effect and cannot meet the needs of modern consumers for precise skin care.

[0003] Secondly, the storage of hydrogels is also a difficult problem. Conventional hydrogels need to be stored in a wet state. Once the temperature exceeds 80°C, the hydrogel may melt. In order to prevent the hydrogel from deteriorating, a large amount of preservatives usually need to be added, which not only increases the cost, but also may pose a potential threat to the skin health of consumers. In addition, the transportation cost of wet hydrogels is relatively high, and the active ingredients are prone to inactivation during transportation and storage, thus affecting the skin care effect of the facial mask.

[0004] Finally, the low efficiency of the production process is also a problem faced by traditional facial masks. The coating process accuracy of multi-region composite materials is insufficient, resulting in the active ingredients being easily damaged by high temperature during the coating process. At the same time, the traditional facial mask production process requires multi-step packaging, which not only reduces the production efficiency, but also increases the production cost. Summary of the Invention

[0005] The purpose of the present invention is to provide a local positioning hydrogel dressing and a preparation method thereof, which can accurately position the face, have a long storage time, and high production efficiency.

[0006] To achieve the above purpose, the present invention provides the following technical solutions:

[0007] A local positioning hydrogel dressing, comprising:

[0008] A base cloth, which is a plant fiber hydrospun cloth made of a blend of lyocell fiber and viscose, and the water absorption rate is ≥300%:

[0009] A hydrogel layer, which is formed by a fixed-point coating process of a modified sodium polyacrylate hydrogel in a local area of the base cloth;

[0010] An active ingredient layer, which is formed by attaching the active ingredient after low-temperature freeze-drying to the surface of the hydrogel layer, has a porous structure, and the active ingredient is released when it meets water.

[0011] Preferably, the ratio of lyocell fiber to glue fiber in the base fabric is 6:4, the mesh structure of the base fabric is 40 to 70 mesh, and the gram weight is 10 to 20 g / m 2 ; the thickness of the hydrogel layer is 0.5 to 1.2 mm, and the mass of the coated modified sodium polyacrylate hydrogel is 8 to 12 times the mass of the base fabric.

[0012] Preferably, the composition of the modified sodium polyacrylate hydrogel includes:

[0013] Modified sodium polyacrylate 10wt%

[0014] PEG-400 15wt%

[0015] Tremella polysaccharide 0.05wt%

[0016] Sodium hyaluronate 0.02wt%

[0017] The balance is water.

[0018] Preferably, 0.1 to 0.5wt% of silver ion antibacterial agent or 0.1 to 0.5% of thermochromic microcapsules are added to the hydrogel layer.

[0019] Preferably, the active ingredients contained in the active ingredient layer are at least one of hexapeptide-8, acetyl octapeptide-3, cross-linked hyaluronic acid and bakuchiol.

[0020] Preferably, the dressing contains at least two functional zones corresponding to different regions of the face, and the hydrogel layers of each zone contain different combinations of active ingredients; the penetration rates of the active ingredients in each zone are different.

[0021] A preparation method of a local positioning hydrogel dressing includes the following steps:

[0022] Step 1: The base fabric is subjected to plasma treatment; the treatment power is 50 W and the treatment time is 30 s;

[0023] Step 2: The base fabric is cut into a shape adapted to facial anatomy by numerical control cutting:

[0024] Step 3: After the hydrogel layer is spot-coated by screen printing process, it is dried by hot air at 130 °C for 2 to 5 minutes to form a dry gel layer;

[0025] Step 4: The active ingredient solution is sprayed onto the gel surface by ultrasonic atomization spraying, and vacuum freeze-dried at -50 to -30 °C for 3 to 5 hours to form a porous active ingredient layer.

[0026] Preferably, in Step 3, a 300-mesh screen plate is used for coating, and the overprint accuracy is controlled within ±0.05 mm.

[0027] Preferably, the atomization particle size of the active ingredient solution is 10-20 μm, and the porosity of the porous structure formed after freeze-drying is 60-80%.

[0028] Preferably, in the plasma treatment of the first step, carboxyl active groups are sprayed on the surface of the base fabric, and the carboxyl active groups and the carboxylate groups in the hydrogel layer form an ionic cross-linked structure through sodium ion bridging, and the cross-linking

[0029] The present invention has the following beneficial effects:

[0030] I. Breakthrough in dry state stability: The ratio of modified sodium polyacrylate (10%) and PEG-400 (15%), combined with the high-temperature curing process at 130 °C, forms a stable cross-linked network, enabling the hydrogel layer to be stored in a dry state for 12 months (recovery rate ≥ 95%). Compared with traditional wet hydrogels, cold chain transportation is not required, and the logistics cost can be reduced by more than 30%.

[0031] II. Protection of active ingredients: The low-temperature freeze-drying process (-50 to -30 °C) combined with the porous structure (porosity 60-80%) reduces the degradation rate of peptide active ingredients to <5% (traditional process >15%), reducing the inactivation rate of active ingredients by 2-3 times.

[0032] III. Spatial precise positioning: The multi-zone design combined with 300-mesh screen printing achieves ±0.05 mm. The oil adsorption amount of the T-zone sticker (12.3 mg / cm 2 ) is increased by 41% compared with the traditional mud mask, with the targeted advantage of a 2-3-fold increase in absorption rate.

[0033] IV. Sequential controlled release: The porous structure (porosity 60-80%) and the high water absorption rate of the base fabric (≥300%) cooperate to form a gradient penetration effect. For example, the penetration rate of caffeine at 35 °C is 2.1 times higher than that at 25 °C, achieving temperature-responsive release.

[0034] V. Improvement in production efficiency: Integrating plasma treatment (50 W / 30 s), screen printing, and freeze-drying processes, the production speed reaches 2000 pieces per hour. Compared with the traditional step-by-step process, the efficiency is increased by 4 times, and multiple processes are avoided, reducing the material loss by 10-15%.

[0035] VI. Environmental protection cost advantage: The plant fiber base fabric (lyocell ≥ 60%) has a biodegradation rate >90%, combined with plasma treatment (reducing the dosage of PEG-400 by 20%), meeting the environmental requirements of EU EC / 1223 regulations for cosmetics.

[0036] VII. Dual antibacterial ability: Silver ions (0.1 - 0.5 wt%) cooperate with tremella polysaccharide. Experimental data shows that the antibacterial zone against Staphylococcus aureus reaches 12 mm (blank control: 5 mm), forming a "dual mechanism of ionic antibacterial + flora regulation", providing technical support for the transformation of wound dressings. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the drawings required in the embodiments. It should be understood that the following drawings only show some embodiments of the present invention, and therefore should not be regarded as limiting the scope. For those of ordinary skill in the art, without creative efforts, other related drawings can also be obtained based on these drawings.

[0038] Figure 1 Schematic diagram of Embodiment 1 of the present invention.

[0039] Figure 2 Schematic diagram of Embodiment 2 of the present invention.

[0040] Figure 3 Schematic diagram of Embodiment 3 of the present invention.

[0041] Figure 4 Physical diagram of ordinary gel fabric.

[0042] Figure 5 Physical diagram of ordinary non-woven fabric (lyocell fiber).

[0043] Figure 6 Physical diagram of the dressing fabric of Embodiment 1 of the present invention.

[0044] Figure 7 Microscopic image of ordinary chemical fiber non-woven fabric.

[0045] Figure 8 Microscopic image of ordinary non-woven fabric (lyocell fiber).

[0046] Figure 9 Microscopic image of the dressing fabric of Embodiment 1 of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0047] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative efforts belong to the scope of protection of the present invention.

[0048] Embodiment 1: Eye contour anti-wrinkle care dressing (0.5 mm thick)

[0049] AsFigure 1 As shown, this embodiment is designed for fine lines and dynamic lines around the eyes, and uses an ultra-thin hydrogel layer (0.5 mm) to balance the transdermal efficiency and comfort. The base fabric is a 70-mesh lyocell / viscose blended fabric (6:4), which has excellent softness and breathability (gram weight 15 g / m 2 ), and carboxyl groups are grafted on the surface after plasma treatment (50 W / 30 s), and a strong adhesion interface is formed with the hydrogel layer through sodium ion crosslinking. The hydrogel formula contains 10% modified sodium polyacrylate as the main skeleton, introduces 15% PEG-400 to enhance flexibility, and is supplemented with 0.05% tremella polysaccharide and 0.02% sodium hyaluronate to regulate moisture retention and microenvironment. The active ingredient layer is loaded with 2% hexapeptide-8 and 1% acetyl octapeptide-3, and a porous structure (porosity 70%) is formed by ultrasonic atomization spraying. After freeze-drying, the active substances are evenly distributed in the gel network.

[0050] Test items:

[0051] Transdermal absorption rate test: Using the Franz diffusion cell method, the dressing is covered on the surface of ex vivo skin and placed for 24 hours under constant temperature and humidity conditions at 37 °C. The concentration of hexapeptide-8 in the receiving pool is detected by HPLC.

[0052] Hydrogel recovery rate test: The dry dressing is weighed after absorbing water and swelling, and the volume recovery rate is calculated (formula: recovery rate = (weight after water absorption - dry weight) / dry weight × 100%).

[0053] Active ingredient release rate test: The dressing is placed in a 37 °C PBS solution, and samples are taken regularly to detect the release amount of hexapeptide-8 by HPLC.

[0054] The test data shows:

[0055] The transdermal absorption rate reaches 58.7 ± 2.9 μg / cm 2 (superior to the traditional facial mask of 22.5 μg / cm 2 ), benefiting from the thin layer with high porosity structure to accelerate the diffusion of active substances; the hydrogel recovery rate is 93.1% (volume recovery rate after dry state water absorption), indicating that the cross-linked network (cross-linking density 0.95 mmol / g) has both elasticity and stability; in the 24-hour active ingredient release rate, the release rate of hexapeptide-8 is 72.4%, and the release rate of acetyl octapeptide-3 is slightly lower, which may be due to the different diffusion rates caused by the molecular weight difference.

[0056] The image shows:

[0057] Figures 4 to 5 is a physical picture of ordinary fabric, Figures 7 to 8 is a microscopic picture of ordinary fabric, Figure 6 and Figure 9They are respectively the physical and microscopic images of the dressing fabric in this embodiment. By comparing the pictures of ordinary fabrics and the pictures of this embodiment, it can be clearly seen that in the dressing fabric of this embodiment, the gel layer adheres to the base fabric fibers more evenly.

[0058] Example 2: T-zone oil control and anti-acne dressing (0.8 mm thick)

[0059] As Figure 2 shown, this embodiment focuses on the dual needs of oil control and anti-acne for oily skin, and uses a medium-thickness hydrogel layer (0.8 mm) to carry a higher active ingredient load. The base fabric is a 60-mesh lyocell / viscose blended fabric (6:4, 12 g / m 2 ²), which forms an ionic bond with the hydrogel after plasma activation. In the hydrogel formula, 1% bakuchiol is used as a photosensitizer to inhibit sebum secretion, 0.5% cross-linked hyaluronic acid constructs a sustained-release microenvironment, and 15% PEG-400 is used to reduce the viscosity to adapt to thick-layer coating. The active ingredient layer is loaded with bakuchiol (1%) and cross-linked hyaluronic acid (0.5%), and a dense porous structure (porosity 68%) is formed by freeze-drying.

[0060] Test items:

[0061] Oil control adsorption amount test: In a constant temperature and humidity environment, the dressing is applied to the skin surface, removed and weighed after 4 hours, and the adsorbed oil amount is calculated (formula: adsorption amount = (dressing weight - initial weight) / initial weight × 100%).

[0062] High-temperature active ingredient retention rate test: Store in an environment of 40°C / 75% RH for 3 months, and detect the residual rate of bakuchiol by HPLC.

[0063] Bakuchiol thermal degradation test: Place the sample in an oven at 120°C, and take samples regularly for HPLC analysis of the degradation products.

[0064] Test data shows that:

[0065] The oil control adsorption amount reaches 12.3 mg / cm 2 (exceeding the market mud mask of 8.7 mg / cm 2 ²), attributed to the synergistic adsorption of oil by the hydrophilicity and porous structure of the hydrogel;

[0066] [[ID=z35]]In the 40°C accelerated aging test, the active ingredient retention rate is 97.3%, confirming that the plasticizing effect of PEG-400 effectively resists high-temperature degradation;

[0067] The thermal stability test of the oil control ingredient shows that the degradation rate of bakuchiol at high temperature < 5% (detected by HPLC), which is better than that of conventional lipophilic ingredients (> 20%).

[0068] Example 3: Nasolabial fold repair patch (1.2 mm thick)

[0069] As shown Figure 3 in the figure, for deep wrinkle repair, in this embodiment, the thickest hydrogel layer (1.2 mm) is used to provide continuous mechanical support and slow release of active substances. The base fabric is selected as 40-mesh lyocell / viscose blended fabric (6:4, 18 g / m 2 ²), strengthening the structural support force. The hydrogel formula takes 10% modified sodium polyacrylate as the core, and adds 0.5% cross-linked hyaluronic acid as a three-dimensional network cross-linking agent to improve the toughness of the gel. The active ingredient layer is loaded with 5% hexapeptide-8 (promoting collagen production) and 0.5% cross-linked hyaluronic acid (moisturizing and microneedle effect), and a macroporous structure (porosity 65%) is formed by freeze-drying.

[0070] Test items:

[0071] Collagen synthesis rate test (anti-wrinkle effect test): Cultivate fibroblasts in vitro, add dressing extract, and detect the amount of collagen synthesis by ELISA after 72 hours.

[0072] Tensile strength test: Use a universal material testing machine to stretch the dressing at a rate of 50 mm / min until it breaks, and record the maximum stress value.

[0073] Temperature-responsive release test: Immerse the dressing in PBS solutions at 25°C and 37°C respectively, and take samples regularly to detect the release rate of hexapeptide-8.

[0074] Test data shows that:

[0075] The anti-wrinkle effect is significant. In vitro experiments, the collagen synthesis rate of fibroblasts increased by 18.7%, which is 6.2% better than that of the control group;

[0076] In the mechanical property test of the hydrogel, the tensile strength reached 12.5 MPa (close to the standard of medical-grade dressings);

[0077] The temperature gradient release experiment found that the release rate of hexapeptide at 37°C was 40% higher than that at 25°C, matching the temperature response characteristics of human skin.

[0078] Example 4: Antibacterial medical dressing (containing silver ions)

[0079] This embodiment is extended to the medical field, and wound care is realized through a silver ion antibacterial system. The base fabric is the same as that in Example 1, and 0.1% silver nitrate (reduced to Ag+) and 0.05% tremella polysaccharide (slow release and pH value regulation) are added to the hydrogel layer. The active ingredient layer is loaded with 0.5% bakuchiol (preventing infection) and 2% chitosan (promoting wound healing), and an antibacterial porous layer (porosity 70%) is formed after freeze-drying.

[0080] Test items:

[0081] Antibacterial zone test: The dressing was applied to an agar plate inoculated with Staphylococcus aureus, and the diameter of the antibacterial zone was measured after 24 hours of incubation.

[0082] Cytotoxicity test: L929 cells were co-cultured with the dressing extract for 72 hours, and the cell viability was determined by the MTT method.

[0083] Silver ion sustained-release rate test: The dressing was immersed in PBS solution, and the silver ion release amount was detected by ICP-MS at regular intervals.

[0084] Test data showed that:

[0085] The diameter of the antibacterial zone reached 13.2 ± 0.9 mm (against Staphylococcus aureus), and silver ions played a role by destroying the bacterial cell membrane and DNA;

[0086] The cytocompatibility test showed that the viability of L929 cells > 95%, and the biotoxicity risk was extremely low;

[0087] The 24-hour silver ion sustained-release rate was 35% (detected by ICP-MS), and the continuous release inhibited bacterial regeneration.

[0088] Example 5: Dual-zone composite dressing (nasal wing oil control + jaw anti-wrinkle)

[0089] In this example, a differential functional area was constructed on the same base fabric through a two-color screen printing process, and independent active systems were designed for the nasal wing area (high oil secretion) and the jaw area (prone to wrinkles) respectively.

[0090] Oil control area (nasal wing, accounting for 20% of the area):

[0091] The hydrogel layer contains 0.8% bakuchiol (inhibiting sebaceous gland activity) and 0.2% silver nitrate (reduced to Ag+ antibacterial agent), and the porosity is controlled at 66% by adjusting the addition amount of tremella polysaccharide (0.1 wt%). The base fabric uses 60-mesh lyocell / viscose blended fabric (gram weight 18 g / m 2 ), and after plasma treatment, a cross-linking density of 0.8 mmol / g is formed with the hydrogel layer.

[0092] Anti-wrinkle area (jaw, accounting for 80% of the area):

[0093] The hydrogel layer is loaded with 3% hexapeptide-8 (1.5%) and 1.5% acetyl octapeptide-3 (synergistically inhibiting neurotransmitter release), and 0.05% sodium hyaluronate is added to improve the moisturizing property. After freeze-drying, the porosity reaches 72% to accelerate penetration.

[0094] Test items:

[0095] Regional penetration difference test: Using rhodamine B (oil-control area) and sodium fluorescein (anti-wrinkle area) as tracers, the penetration depth of active ingredients in ex vivo skin within 24 hours was observed by confocal microscopy, and the penetration amount per unit area (μg / cm 2 ) was calculated.

[0096] Oil-control and antibacterial synergistic effect test: In an in vitro sebum gland model, the dressing was attached to a simulated sebum secretion device (37°C, RH 65%), and after 4 hours, the following were detected:

[0097] Oil adsorption amount (gravimetric method)

[0098] Survival rate of Staphylococcus aureus (ATP bioluminescence method)

[0099] Dipeptide synergistic anti-wrinkle test:

[0100] Using a 3D culture model of human dermal fibroblasts (HDF), the following were added respectively:

[0101] Single group: 1.5% hexapeptide-8

[0102] Single group: 1.5% acetyl octapeptide-3

[0103] Compound group: 1.5% hexapeptide-8 + 1.5% acetyl octapeptide-3

[0104] After 72 hours, the expression level of COL1A1 gene was detected by qPCR, and the secretion amount of type I collagen was detected by ELISA.

[0105] The test data showed that:

[0106] Penetration difference: The penetration amount in the anti-wrinkle area reached 91.2 ± 4.3 μg / cm after 24 hours 2 , which was 108% higher than that in the oil-control area (43.7 ± 2.1 μg / cm 2 ), benefiting from the high porosity (72% vs 66%) and the diffusion advantage of small peptide molecules.

[0107] Oil-control and antibacterial synergy: Bakuchiol reduced the sebum secretion amount by 42.3% (vs the control group), and the Ag+ antibacterial agent reduced the bacterial survival rate to 6.2%. The synergistic antibacterial rate of the two increased by 37% (p<0.01).

[0108] Dipeptide synergistic effect: The expression level of COL1A1 gene in the compound group was 1.8 times higher than that in the single group, and the secretion amount of type I collagen reached 21.3 ± 1.2 ng / mL (the average value of the single group was 12.4 ng / mL), confirming that the dipeptide produced a synergistic effect through the activation of the TGF-β / Smad and MAPK dual pathways.

[0109] Example 6: Full-face multi-region intelligent responsive dressing (including thermosensitive color-changing indication)

[0110] Based on the dual - zone design of Example 5, this embodiment adds a temperature - responsive color - changing layer (tip area) to form a multi - zone collaborative care system:

[0111] Thermosensitive color - changing area (tip of the nose, accounting for 5% of the area)

[0112] Add 0.1% thermochromic microcapsules (containing crystal violet lactone / bisphenol A complex, color - changing threshold 35°C) to the hydrogel formula

[0113] Active ingredient: 1% menthol (cooling agent)

[0114] Function verification: Through monitoring with an infrared thermal imager, when the skin temperature > 35°C, the color - changing area changes from white to blue, indicating that the user can remove the dressing.

[0115] Table 1: Summary table of data for individual test items

[0116]

[0117]

[0118]

[0119]

[0120] As shown in Table 1, the test data of each Example 1 is analyzed as follows:

[0121] Example 1: Eye - contour anti - wrinkle care dressing

[0122] 1. The transdermal absorption rate is increased by 160%

[0123] Test data: 58.7 ± 2.9 μg / cm 2 (This invention) compared with 22.5 μg / cm 2 (Traditional facial mask)

[0124] In this embodiment, through the composite design of an ultra - thin hydrogel layer (0.5 mm) and a high porosity (70%), the diffusion rate of the active ingredient is significantly increased.

[0125] In traditional cognition, a thin - layer hydrogel may affect the loading capacity due to insufficient mechanical strength. However, by grafting carboxyl groups on the base fabric through plasma treatment (50 W / 30 s) to form sodium - ion bridging cross - linking (cross - linking density 0.95 mmol / g), both the interfacial adhesion force is enhanced and the integrity of the pore structure is maintained, breaking through the compatibility contradiction between thin - layer and high permeability.

[0126] 2. The hydrogel recovery rate is increased by 28%

[0127] Test data: 93.1% (this invention) compared with 65 - 75% (ordinary hydrogel)

[0128] The dry - state stability of this embodiment is significantly better than that of conventional hydrogels.

[0129] Working principle: Modified sodium polyacrylate (10%) and PEG - 400 (15%) cooperate to construct a double - crosslinked network (chemical crosslinking + hydrogen - bond physical crosslinking). After curing by hot - air drying at 130°C, a stable three - dimensional network is formed. When absorbing water and swelling, the network recovery rate reaches more than 93%, overcoming the defect that traditional hydrogels are prone to brittle fracture in the dry state.

[0130] Example 2: T - zone oil - control and anti - acne dressing

[0131] 1. The oil - control adsorption amount is increased by 41%

[0132] Test data: 12.3 mg / cm 2 (this invention) compared with 8.7 mg / cm 2 (market mud mask)

[0133] The hydrophilicity of the hydrogel and the porous structure (porosity 68%) of this embodiment cooperate to achieve a significant oil - adsorption effect.

[0134] Traditional oil - control materials (such as kaolin) rely on physical adsorption, while this invention realizes a "adsorption + inhibition" dual oil - control mechanism by inhibiting the activity of sebaceous glands with bakuchiol (1%) and constructing a slow - release micro - environment with cross - linked hyaluronic acid (0.5%), breaking through the limitations of a single action mode.

[0135] 2. The high - temperature activity retention rate is increased by 21%

[0136] Test data: 97.3% (this invention) compared with 80 - 85% (conventional process)

[0137] The plasticizing effect of PEG - 400 in this embodiment significantly reduces the risk of thermal degradation.

[0138] The addition of 15% PEG - 400 reduces the molecular - chain rigidity of modified sodium polyacrylate, forms a dynamic hydrogen - bond network under the conditions of 40°C / 75% RH, inhibits the molecular movement of bakuchiol, and its thermal degradation rate < 5% (control group > 20%), breaking the traditional understanding that fat - soluble components are unstable at high temperatures.

[0139] Example 3: Nasolabial fold repair patch

[0140] 1. The collagen synthesis rate is increased by 300%

[0141] Test data: 18.7% (this invention) compared with 6.2% (traditional anti - wrinkle patch)

[0142] In Example 6, the synergistic effect of hexapeptide-8 and cross-linked hyaluronic acid significantly promotes collagen production.

[0143] Mechanism of action: 5% hexapeptide-8 activates the TGF-β / Smad pathway, while 0.5% cross-linked hyaluronic acid enhances the transdermal efficiency through the microneedle effect. The two work together to increase the collagen secretion level to 21.3 ng / mL (12.4 ng / mL in the single peptide group), demonstrating the synergistic effect of multi-target intervention.

[0144] 2. The temperature-responsive release rate is increased by 40%

[0145] Test data: The release rate at 37°C is 40% higher than that at 25°C (no change in the control group)

[0146] By regulating the porosity (65%) and cross-linking density (1.2 mmol / g), the hydrogel network undergoes a swelling phase change at body temperature, and the pore size expands to accelerate the diffusion of the active substance, achieving intelligent temperature-controlled release and breaking through the passive release mode of traditional patches.

[0147] Example 4: Antibacterial medical dressing

[0148] 1. The diameter of the inhibition zone is increased by 164%

[0149] Test data: 13.2 ± 0.9 mm (in this invention) compared with 5 - 7 mm (ordinary antibacterial dressing)

[0150] In this example, silver ions (0.1%) and tremella polysaccharide (0.05%) synergistically form a dual antibacterial mechanism.

[0151] Silver ions damage the bacterial cell membrane, and tremella polysaccharide regulates the microenvironment pH to inhibit biofilm formation. The two work together to increase the antibacterial rate by 37% (p < 0.01), breaking through the limitation that single antibacterial agents are prone to drug resistance.

[0152] 2. The cytotoxicity is reduced by 30%

[0153] Test data: The cell survival rate > 95% (in this invention) compared with 70 - 85% (silver-containing dressings)

[0154] Principle of operation: The silver ions are slowly released through the freeze-dried porous structure (porosity 70%), and combined with chitosan (2%) to form a positive charge barrier, reducing the direct contact of silver ions with cells and solving the problem of poor cell compatibility of traditional silver dressings.

[0155] Example 5: Dual-zone composite dressing

[0156] 1. The regional penetration difference reaches 108%

[0157] Test data: In the anti-wrinkle area, it is 91.2 μg / cm 2 compared with 43.7 μg / cm in the oil-control area2

[0158] In this embodiment, precise osmotic control is achieved through zonal porosity regulation (72% compared to 66%).

[0159] Using a 300-mesh screen printing process (overprinting accuracy ±0.05 mm), hydrogel layers with different crosslinking densities are constructed on the same base fabric. The high-porosity in the anti-wrinkle area accelerates the diffusion of small molecule peptides, and the dense structure in the oil-control area prolongs the action time of bakuchiol, solving the technical problem that traditional facial masks cannot provide zonal care.

[0160] Example 6: Intelligent thermosensitive dressing

[0161] 1. Precise control of the temperature-responsive color change threshold

[0162] Test data: Color change (white and blue) is triggered at 35°C

[0163] Thermochromic microcapsules (crystal violet lactone / bisphenol A complex) are integrated into the hydrogel network, and the color change temperature is controlled by the wall thickness of the microcapsules (±1°C accuracy), providing a visual usage indication and breaking through the defect that traditional dressings lack real-time feedback.

[0164] In addition to the above separately compared test items, it is also necessary to verify the common advantages of Examples 1 to 6.

[0165] Test items:

[0166] Production efficiency: By integrating plasma treatment (50 W / 30 s) and 300-mesh screen printing process, a continuous production line is constructed, and the number of complete dressings produced per unit time (hour) is recorded.

[0167] Dry-state storage time: After the hydrogel dressing is sealed and packaged, it is placed in an incubator at 25°C, and samples are taken monthly to detect the content of active ingredients (such as HPLC analysis) and the growth of microorganisms (such as colony counting).

[0168] Hydrogel recovery rate: The dry hydrogel is immersed in deionized water (25°C), and the volume change is measured at regular intervals until swelling equilibrium (stable volume) is reached, and the recovery rate is calculated.

[0169] High-temperature retention rate of active ingredients: The dressing containing active ingredients is placed in an incubator at 40°C for accelerated aging, and samples are taken at regular intervals to detect the concentration of active substances (such as ultraviolet spectrophotometry or mass spectrometry).

[0170] Reduction rate of transportation cost: Simulating the logistics environment (vibration, stacking, temperature and humidity cycling), comparing the packaging volume, weight and cold chain requirements of dry and wet dressings, and calculating the difference in comprehensive transportation cost.

[0171] Biodegradation rate: In vitro experiments, the dressing was immersed in PBS (pH 7.4, 37 °C) or buffer containing hyaluronidase, taken out regularly, freeze-dried and weighed, and the mass loss rate was calculated.

[0172] Table 2: Comparison of common properties between Examples 1-6 and the control group

[0173]

[0174]

[0175] It can be analyzed from the test or verification data in Table 2 that:

[0176] 1. Production efficiency (pieces / hour)

[0177] Working principle: The present invention integrates plasma treatment (50W / 30s) with 300-mesh screen printing process to form a continuous production line. Plasma treatment bombards the surface of the base fabric with high-energy particles to remove organic pollutants and activate polar groups (such as hydroxyl and carboxyl groups), increasing the ink adhesion by more than 40%, and at the same time reducing the base fabric transfer and drying links in the traditional step-by-step process. Combining with ultrasonic atomization freeze-drying technology, the active ingredient forms a porous structure (porosity 60-80%) through low-temperature atomization (particle size 10-20μm), avoiding the inactivation of heat-sensitive components caused by high temperature.

[0178] Effect verification: The production speed of the double-zone dressing in Example 5 reaches 2000 pieces / hour, and the material loss is reduced by 10-15%. Compared with the traditional step-by-step process, the overprint accuracy (±0.05mm) of plasma treatment and screen printing can reduce the calibration time, and the single-line production capacity is increased by 4 times.

[0179] 2. Dry storage time (months)

[0180] Technical principle: A double cross-linked network is constructed by using modified sodium polyacrylate (10wt%) and PEG-400. Sodium polyacrylate forms a chemical cross-linking through sodium ion bridging (cross-linking density 0.5-1.2 mmol / g), while PEG-400 enhances the physical cross-linking strength through hydrogen bonds, inhibiting the growth of microorganisms. After curing by hot air drying at 130 °C, the molecular chains form a stable ionic bond and hydrogen bond network, avoiding the microbial reproduction caused by the penetration of water molecules.

[0181] Effect verification: After storing Examples 1-6 at room temperature for 12 months, the inactivation rate of the active ingredient <5% (the control group needs cold chain storage and the inactivation rate >15%). Detection by Fourier transform infrared spectroscopy (FTIR) shows that there is no degradation peak in the cross-linked network during the storage period, proving the structural stability.

[0182] 3. Hydrogel recovery rate (%)

[0183] Technical principle: The recovery ability of the hydrogel depends on the sodium ion bridging crosslinking density and the integrity of the porous network structure. Sodium ions stabilize the polyacrylic acid chains through electrostatic interactions, and the porous structure formed by freeze-drying (pore size 25 - 70 μm) rapidly swells after absorbing water, with a volume recovery rate of 93.1 - 95%. The base fabric is made of lyocell fiber (≥60%) to enhance the water absorption rate (≥300%), and scanning electron microscopy (SEM) observation shows that uniform pores are formed on the fiber surface.

[0184] Effect verification: In Example 3, the diffusion rate of the active substance of the hydrogel at 37°C is 2.1 times higher than that at 25°C (caffeine model), indicating that the porosity and temperature-responsive release have a synergistic effect.

[0185] 4. High-temperature retention rate of active ingredient (%)

[0186] Technical principle: Reduce heat exposure through low-temperature ultrasonic atomization technology, and combine with a porous freeze-dried layer (porosity 60 - 80%) to reduce the oxidation risk. During the freeze-drying process, the active ingredient is encapsulated in the nanopores. When accelerating aging at 40°C, the pore structure restricts the diffusion of oxygen and delays oxidative degradation. X-ray photoelectron spectroscopy (XPS) shows that the carbon-oxygen ratio (C / O) of the active ingredient in Example 2 only decreases by 2.3% after aging, indicating a very low degree of oxidation.

[0187] Effect verification: The high-temperature retention rate of the active ingredient in Example 2 reaches 97.3%, which is significantly better than the traditional freeze-drying process (80 - 85%). DSC thermal analysis shows that the glass transition temperature (Tg) of the freeze-dried layer is increased to 120°C, proving enhanced thermal stability.

[0188] 5. Reduction rate of transportation cost (%)

[0189] Technical principle: Dry-state lightweight design (basis weight of the base fabric 10 - 20 g / m 2 ) reduces the volume by 50% and eliminates the need for cold-chain transportation. The mechanical strength of the lyocell fiber base fabric (tensile strength 1.98 MPa) ensures compressive resistance during transportation, while plasma treatment reduces the PEG-400 dosage by 20% and avoids microplastic pollution.

[0190] Effect verification: Compared with traditional wet dressings, the transportation cost is reduced by 30%. Through logistics simulation experiments, it shows that the stacking height of dry-state packaging is increased by 2 times, and the utilization rate of storage space is increased by 45%.

[0191] 6. Biodegradation rate (%)

[0192] Technical principle: Lyocell fiber (plant-based) and the design without PEG residue comply with the EC / 1223 regulation. Cellulose nanofibrils (QCNF) show a degradation rate >90% after 28 days through enzymatic hydrolysis experiments, and plasma treatment does not introduce non-degradable chemical residues.

[0193] Effect verification: The soil burial experiment shows that the base fabrics of Examples 1-6 are completely degraded within 60 days, while the residual rate of the synthetic fiber base fabric is >50%. Through gel permeation chromatography (GPC) detection, the molecular weight of the degradation product is <1000 Da, proving no ecological toxicity.

[0194] Through material modification (sodium polyacrylate / PEG-400 crosslinking), process innovation (plasma + screen printing integration), and structural design (porous freeze-dried layer + partition coating), the present invention systematically solves the problems of poor dry-state stability, easy inactivation of active ingredients, and low production efficiency of traditional dressings. Common test data show that the present invention is significantly superior to traditional processes in terms of storage time (12 months), production efficiency (2000 pieces / hour), and environmental friendliness (biodegradation rate >90%). At the same time, precise care is achieved through partition design (such as Example 5), and the technical advantages cover both the cosmetics and medical dressing fields.

[0195] The above are only specific embodiments of the present invention, but the technical features of the present invention are not limited thereto. Any simple changes, equivalent replacements, or modifications made based on the present invention to solve substantially the same technical problems and achieve substantially the same technical effects are all covered by the protection scope of the present invention.

Claims

1. A local positioning hydrogel dressing, characterized in that: Comprising: A base fabric, a plant fiber spunlace fabric made of a blend of lyocell fiber and viscose, with a water absorption rate ≥ 300%: A hydrogel layer, formed by locally coating a modified sodium polyacrylate hydrogel on the base fabric through a fixed-point coating process; An active ingredient layer, formed by attaching the active ingredient after low-temperature freeze-drying to the surface of the hydrogel layer, having a porous structure, and the active ingredient releases upon contact with water.

2. The partial positioning hydrogel dressing according to claim 1, characterized in that: The ratio of lyocell fiber to glue fiber in the base fabric is 6:

4. The mesh structure of the base fabric is 40 to 70 meshes, and the gram weight is 10 to 20 g / m 2 ; the thickness of the hydrogel layer is 0.5 to 1.2 mm, and the mass of the coated modified sodium polyacrylate hydrogel is 8 to 12 times that of the base fabric.

3. The partial positioning hydrogel dressing according to claim 3, characterized in that: The composition of the modified sodium polyacrylate hydrogel includes: Modified sodium polyacrylate 10wt% PEG-400 15wt% Tremella polysaccharide 0.05wt% Sodium hyaluronate 0.02wt% The balance is water.

4. The partial positioning hydrogel dressing according to claim 3, wherein: 0.1 to 0.5wt% of silver ion antibacterial agent is added to the hydrogel layer or 0.1 to 0.5% of thermochromic microcapsules is added.

5. The local positioning hydrogel dressing according to claim 3, wherein: The active ingredient contained in the active ingredient layer is at least one of hexapeptide-8, acetyl octapeptide-3, cross-linked hyaluronic acid, and bakuchiol.

6. The local positioning hydrogel dressing according to claim 5, characterized in that: The dressing comprises at least two functional zones, corresponding to different regions of the face respectively, and the hydrogel layers of each zone contain different combinations of active ingredients; the penetration rates of the active ingredients in each zone are different.

7. A method for preparing the hydrogel dressing according to any one of claims 1 to 6, characterized in that: Including the following steps: Step 1, plasma treatment of the base fabric; the treatment power is 50W and the treatment time is 30s; Step 2, numerically controlled cutting the base fabric into a shape adapted to the facial anatomy: Step 3, after fixed-point coating of the hydrogel layer by screen printing process, drying it with hot air at 130°C for 2 to 5 minutes to form a dry gel layer; Step 4, spraying the active ingredient solution onto the gel surface by ultrasonic atomization spraying, and freeze-drying it under vacuum at -50 to -30°C for 3 to 5 hours to form a porous active ingredient layer.

8. The preparation method according to claim 7, characterized in that: In Step 3, a 300-mesh screen plate is used for coating, and the overprint accuracy is controlled within ±0.05mm.

9. The preparation method according to claim 8, characterized in that: The atomization particle size of the active ingredient solution is 10 - 20μm, and the porosity of the porous structure formed after freeze-drying is 60 - 80%.

10. The preparation method according to claim 9, wherein: In the plasma treatment of Step 1, carboxyl active groups are sprayed on the surface of the base fabric, and the carboxyl active groups and the carboxylate groups in the hydrogel layer are bridged by sodium ions to form an ionic cross-linked structure, and the cross-linking density is 0.5 - 1.2mmol / g.

Images