Device and method for gradually adjusting glucose concentration of in-vitro embryo culture solution

Through the device of the micro storage chamber and sustained release channel, combined with sensors and control units, the phased automatic adjustment of glucose concentration is achieved, solving the accuracy and non-destructive problems of glucose concentration regulation in in vitro embryo culture, and improving the quality and success rate of embryo culture.

CN120399883APending Publication Date: 2025-08-01TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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Patent Information

Application Number
CN202510908701.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-02
Publication Date
2025-08-01

AI Technical Summary

Technical Problem

In the prior art, it is difficult to achieve accurate and non-destructive regulation of glucose concentration during in vitro embryo culture, resulting in mechanical and environmental stress responses, affecting embryo quality and culture success rate.

Method used

A device with multiple micro liquid storage chambers and sustained release channels is used, combined with sensors and control units, to achieve phased and automated regulation of glucose concentration, avoiding concentration mutations, and meeting the needs of different stages of embryo development.

Benefits of technology

Significantly improve the quality and success rate of embryo culture, and through multi-stage micro-sugar control, reduce mechanical stress response, improve blastocyst formation rate and subsequent implantation rate, and reduce the frequency of artificial intervention.

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Abstract

The invention belongs to the technical field of assisted reproduction, and particularly relates to a device and a method for gradually adjusting the glucose concentration of an in-vitro embryo culture solution. The device comprises at least two miniature liquid storage bins, wherein each miniature liquid storage bin is filled with a high-concentration glucose solution in advance; the slow release channel is respectively connected with each micro liquid storage bin and the culture solution main container; the culture solution main container is used for accommodating an embryo and a basal culture medium; the control unit is used for sequentially opening the release ports of the miniature liquid storage bins, so that the high-concentration glucose solution sequentially flows into the culture solution main container through the slow release channels. The technical means of staged closed-loop micro sugar control is introduced into the structure and the using method of the device, so that the accurate adjustment of the sugar concentration of the in-vitro embryo culture solution is realized, the requirements of embryos in different development stages can be effectively met, and the embryo culture quality and the subsequent development potential are remarkably improved.
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