Boron concentration monitoring method, computer equipment and storage medium

Abstract

The invention relates to the technical field of medical imaging, and discloses a boron concentration monitoring method, computer equipment and a storage medium, and is applied to a Compton camera system. Performing first imaging on the monitored object through the first detector and the second detector to obtain first imaging data in a first direction; the first detector and the second detector are controlled to move in the first direction, and when the first detector and the second detector are away from the monitored object by a second distance, second imaging is carried out to obtain second imaging data in the first direction; finally, boron concentration monitoring is performed on the monitored object based on the first imaging data and the second imaging data. Therefore, errors existing in a single imaging method are corrected, and the monitoring precision is improved by utilizing the dynamic multi-distance information, so that the real-time performance and the accuracy of boron concentration monitoring are improved.

Description

Technical Field

[0001] This application relates to the field of medical imaging technology, and in particular, to a boron concentration monitoring method, a computer device, and a storage medium. Background Art

[0002] Boron Neutron Capture Therapy (BNCT) is a cutting-edge and efficient cancer treatment technology. Its core advantage lies in being able to accurately irradiate tumor cells, thereby effectively killing diseased cells.

[0003] However, the methods for measuring boron concentration in the BNCT process in related technologies still have limitations. There is an urgent need for a boron concentration monitoring method that can achieve dynamic high-precision spatial resolution. Summary of the Invention

[0004] This application aims to at least solve one of the technical problems in related technologies to some extent. For this purpose, this application proposes a boron concentration monitoring method, a computer device, and a storage medium. The main technical solutions adopted in this application include: In a first aspect, an embodiment of this application provides a boron concentration monitoring method, which is applied to a Compton camera system. The Compton camera system includes a first Compton camera group. The first Compton camera group includes a first detector and a second detector that are opposite and parallel to each other in a first direction. The method includes: when the first detector and the second detector are both at a first distance from the monitoring object, performing a first imaging on the monitoring object through the first detector and the second detector to obtain first imaging data in the first direction; controlling the first detector and the second detector to move respectively in the first direction. When the first detector and the second detector are both at a second distance from the monitoring object, performing a second imaging on the monitoring object through the first detector and the second detector to obtain second imaging data in the first direction; monitoring the boron concentration of the monitoring object based on the first imaging data and the second imaging data.

[0005] Optionally, controlling the first detector and the second detector to move respectively in the first direction includes: controlling the first detector and the second detector to move closer to the monitoring object in the first direction and move to a position where they are at a second distance from the monitoring object; where the second distance is less than the first distance; or controlling the first detector and the second detector to move away from the monitoring object in the first direction and move to a position where they are at a second distance from the monitoring object; where the second distance is greater than the first distance.

[0006] Optionally, boron concentration monitoring of the monitoring object based on the first imaging data and the second imaging data includes: performing imaging trend analysis based on the first imaging data and the second imaging data to obtain imaging trend data; correcting the first imaging data or the second imaging data based on the imaging trend data to obtain corrected imaging data, so as to perform boron concentration monitoring of the monitoring object using the corrected imaging data.

[0007] Optionally, the Compton camera system further includes a second Compton camera group, and the second Compton camera group includes a third detector and a fourth detector that are opposite and parallel to each other in the second direction; the first direction and the second direction tend to be perpendicular; the method further includes: during the first imaging, the third detector and the fourth detector are both at a first distance from the monitoring object, and the monitoring object is imaged through the third detector and the fourth detector to obtain third imaging data in the second direction; during the second imaging, the third detector and the fourth detector are both at a second distance from the monitoring object, and the monitoring object is imaged through the third detector and the fourth detector to obtain fourth imaging data in the second direction; correspondingly, boron concentration monitoring of the monitoring object based on the first imaging data and the second imaging data includes: performing boron concentration monitoring of the monitoring object based on the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data.

[0008] Optionally, the first Compton camera group and the second Compton camera group move closer to the monitoring object, and after moving to the allowable distance threshold, the first Compton camera group and the second Compton camera group move away from the monitoring object.

[0009] Optionally, the first detector, the second detector, the third detector, and the fourth detector move synchronously.

[0010] Optionally, while the first detector and the second detector move towards each other at a preset rate in the first direction, the third detector and the fourth detector also move towards each other at the same preset rate in the second direction; or while the first detector and the second detector move away from each other at a preset rate in the first direction, the third detector and the fourth detector also move away from each other at the same preset rate in the second direction.

[0011] Optionally, if the second distance is less than the first distance, boron concentration monitoring of the monitoring object is performed based on the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data, including: performing imaging trend analysis on the first imaging data and the second imaging data to obtain first imaging trend data; using the first imaging trend data to correct the second imaging data to obtain first corrected imaging data; performing imaging trend analysis on the third imaging data and the fourth imaging data to obtain second imaging trend data; using the second imaging trend data to correct the fourth imaging data to obtain second corrected imaging data; and performing boron concentration monitoring of the monitoring object according to the first corrected imaging data and the second corrected imaging data.

[0012] In a second aspect, an embodiment of the present application provides a boron concentration monitoring device applied to a Compton camera system. The Compton camera system includes a first Compton camera group, and the first Compton camera group includes a first detector and a second detector that are opposite and parallel to each other in a first direction. The device includes: a first imaging module configured to, when the first detector and the second detector are both at a first distance from the monitoring object, perform a first imaging of the monitoring object through the first detector and the second detector to obtain first imaging data in the first direction; a second imaging module configured to control the first detector and the second detector to move respectively in the first direction, and when the first detector and the second detector are both at a second distance from the monitoring object, perform a second imaging of the monitoring object through the first detector and the second detector to obtain second imaging data in the first direction; and a concentration monitoring module configured to perform boron concentration monitoring of the monitoring object based on the first imaging data and the second imaging data.

[0013] In a third aspect, the present application further provides a computer device including a memory and a processor. The memory stores a computer program, and when the processor executes the computer program, the steps of the method in any one of the above are implemented.

[0014] In a fourth aspect, the present application further provides a computer-readable storage medium having a computer program stored thereon. When the computer program is executed by a processor, the steps of the method in any one of the above are implemented.

[0015] In a fifth aspect, the present invention provides a computer program product including a computer program. When the computer program is executed by a processor, the steps of the method in any one of the above are implemented.

[0016] In the above embodiments, by moving the detector in the same direction and acquiring imaging data at different distances, the imaging error caused by the near-field approximation or depth resolution limitation of the Compton camera at a single fixed distance is overcome, thereby improving the reliability of the imaging data. Finally, using the dynamic distance information contained in the two imaging data, on the premise of ensuring that the detection efficiency is at a relatively good level and the spatial resolution is good, the dynamic real-time boron concentration monitoring of the monitoring object is carried out, thereby improving the monitoring accuracy and finally obtaining a high-precision boron concentration monitoring result. Description of the Drawings

[0017] In order to more clearly illustrate the specific embodiments of the present application or the technical solutions in the prior art, the following will briefly introduce the drawings required for the description of the specific embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0018] Figure 1a It is a flowchart of a boron concentration monitoring method according to an embodiment of the present application; Figure 1b It is a design diagram of a Compton camera system according to an embodiment of the present application; Figure 1c It is a structural diagram of a detector according to an embodiment of the present application; Figure 2 It is a flowchart of a boron concentration monitoring method according to another embodiment of the present application; Figure 3a It is a flowchart of a boron concentration monitoring method according to still another embodiment of the present application; Figure 3b It is a design diagram of a Compton camera system according to still another embodiment of the present application; Figure 3c It is a schematic diagram of the movement of a detector according to an embodiment of the present application; Figure 4 It is a flowchart of a boron concentration monitoring method according to another embodiment of the present application; Figure 5 It is a structural block diagram of a boron concentration monitoring device according to an embodiment of the present application; Figure 6 It is an internal structural diagram of a computer device according to an embodiment of the present application. Detailed Embodiments

[0019] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the following will clearly and completely describe the technical solutions in the embodiments of this application with reference to the accompanying drawings in the embodiments of this application. Obviously, the described embodiments are part of the embodiments of this application, rather than all of them. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of this application.

[0020] Boron Neutron Capture Therapy (BNCT) is a cutting-edge and efficient cancer treatment technology. Its core advantage lies in being able to accurately irradiate tumor cells, thereby effectively killing diseased cells. However, despite the excellent performance of BNCT in terms of treatment effects, the problem of real-time monitoring of local boron dose remains one of the key challenges restricting its further development. Currently, there are mainly seven methods for measuring boron concentration during the BNCT process, but these methods all have certain limitations. For example, Positron Emission Tomography (PET) can provide a reference value for boron concentration but cannot achieve real-time imaging; Prompt Gamma Ray Spectrometer can achieve real-time imaging but faces great difficulties in measuring uneven boron concentration. The other several methods also have their own advantages and disadvantages, but most are offline measurement means. Therefore, there is an urgent need to develop new online boron concentration monitoring technologies.

[0021] Furthermore, in BNCT, Proton-Gamma Camera Single Photon Emission Computed Tomography (PG-SPECT), as a method for online boron concentration monitoring, can reconstruct a three-dimensional image of boron dose by measuring gamma rays (γ rays) with an energy of 0.478 MeV generated by the reaction of neutrons and boron from multiple angles. However, due to the use of a heavy collimator in the PG-SPECT system, it seriously affects the detection efficiency and spatial resolution. At the same time, the PG-SPECT technology can only measure the boron dose and cannot directly obtain the boron concentration, and its reference value for the final boron concentration assessment remains to be verified. Subsequently, different from the traditional PG-SPECT detection system with a mechanical collimator, the Compton camera provides an innovative solution. Due to its characteristics of being collimatorless, having high energy resolution, and being able to achieve real-time reconstruction of single photons, it is expected to be applied to the PG-SPECT system in the future and show good application prospects. The introduction of the Compton camera may further improve the performance of the PG-SPECT system, especially in real-time monitoring and image reconstruction, providing more accurate and efficient support for BNCT treatment.

[0022] In BNCT boron concentration treatment, in order to achieve real-time monitoring and accurate measurement of boron concentration, it is required to accurately measure the source strength and the contour shape of the source. This requires a very short distance between the Compton camera and the source, which is the so-called "near-field approximation". In this approximation, although the three-dimensional position information of the radiation source can be obtained, it is difficult to express the three-dimensional coordinate position relationship of the points on the cone with an analytical expression; and the near-field approximation error will be amplified due to factors such as the three-dimensional shape and the imaging mechanism of the Compton camera.

[0023] Based on this, according to the embodiments of the present application, a boron concentration monitoring method, a computer device, and a storage medium embodiment are provided. It should be noted that the steps shown in the flowchart of the accompanying drawings can be executed in a computer system such as a set of computer-executable instructions, and although the logical order is shown in the flowchart, in some cases, the steps shown or described can be executed in a different order than here.

[0024] In this embodiment, a boron concentration monitoring method is provided, which is applied to a Compton camera system. The Compton camera system includes a first Compton camera group, and the first Compton camera group includes a first detector and a second detector that are opposite and parallel to each other in the first direction. Figure 1a It is a flowchart of the boron concentration monitoring method according to the embodiments of the present application, including the following steps: S110. When the first detector and the second detector are both at a first distance from the monitoring object, the monitoring object is imaged for the first time through the first detector and the second detector to obtain first imaging data in the first direction.

[0025] Among them, the monitoring object may refer to the target radiation source to be monitored in boron neutron capture therapy, or is called the radiation source area. Exemplarily, the monitoring object may be a boron-10-containing area to be measured. Further, as Figure 1b shown, a first Compton camera group 10 may be arranged around the monitoring object 101, which includes two Compton cameras for capturing gamma ray signals emitted by the monitoring object, namely a first detector 103 and a second detector 105.

[0026] Optionally, the structures of the first detector and the second detector may be as Figure 1cAs shown, each detector is composed of a scattering detector and an absorption detector. Among them, the material of the scattering detector can be silicon (Si), with a pixel of 10×10, the size of each pixel is 0.2 cm×0.2 cm, and the thickness is 0.2 cm. The material of the absorption detector can be cadmium zinc telluride (CdZnTe, CZT), also with 10×10 pixels, the size of each pixel is also 0.2 cm×0.2 cm, but the thickness of the absorption detector is designed to be 0.5 cm. In addition, the distance between the scattering detector and the absorption detector can be set to 5 cm. Through such a design, the detector can effectively record the Compton scattering events of gamma rays and generate corresponding imaging data.

[0027] It should be noted that since the imaging result of a single gamma ray event by the Compton camera is a reconstructed cone with a shape that is narrow at the top and wide at the bottom (the vertex of the cone is at the detector, and the opening angle is determined by the scattering angle), that is to say, when a single Compton camera detects a gamma photon event, it can only determine that its origin is at a certain point on a reconstructed cone surface, but cannot determine the specific depth position of this point on the reconstructed cone surface. This is the inherent depth uncertainty of a single Compton event, which will cause a single-point blurring error.

[0028] Based on this, please continue to refer to Figure 1b , the first detector 103 and the second detector 105 can be symmetrically arranged on both sides of the monitoring object 101 respectively, and the first detector 103 and the second detector 105 can be relatively and parallelly arranged in the first direction.

[0029] Among them, the first direction can be a reference direction determined when arranging the detectors of the first Compton camera group 10. The first direction can be a direction perpendicular to the imaging plane of the first detector 103 or the imaging plane of the second detector 105. Exemplarily, please continue to refer to Figure 1b , take the first direction as the horizontal direction, with the monitoring object as the origin, then the first detector 103 can be arranged on one side of the positive horizontal direction. Oppositely, the second detector 105 can be arranged on the negative horizontal direction side to provide detection data with an opposite viewing angle to the first detector 103.

[0030] It can be understood that by arranging two opposite detectors to simultaneously observe the same gamma photon event, each detector will generate a reconstructed cone. These two reconstructed cones will intersect in three-dimensional space, and the true origin position of the gamma photon can be determined based on the intersection position. That is to say, by using the spatial geometric constraints of multiple viewing angles, the reconstructed cone surface blurred by a single detector is "compressed" to its intersection point or line, thereby greatly improving the depth and spatial resolution to eliminate the imaging error in the depth direction.

[0031] Further, when both the first detector and the second detector are at a first distance from the monitoring object, the monitoring object is imaged for the first time by the first detector and the second detector to obtain first imaging data in a first direction.

[0032] Wherein, the first distance may refer to the initial vertical distance preset between the imaging center of the detector and the geometric center of the monitoring object. For example, the first distance can be taken as 25 cm to ensure that both the first detector and the second detector can cover the entire field of view of the monitoring object, that is, the target radiation source, and to avoid gamma-ray flux saturation caused by too close a distance or resolution degradation caused by too far a distance.

[0033] Subsequently, with the first detector and the second detector both at the first distance from the monitoring object, the first imaging is performed to obtain first imaging data. Wherein, the first imaging data may be three-dimensional imaging data including the energy, position, and intensity information of gamma-ray events at the first distance position in the first direction. Specifically, the 0.478 MeV characteristic gamma rays released after the monitoring object is irradiated by the neutron beam will be synchronously captured by the first detector and the second detector, and the corresponding Compton scattering events will be recorded. Then, the first detector and the second detector can perform event reconstruction based on the collected data, calculate the conical surface trajectory using the Compton scattering formula, and preliminarily locate the spatial distribution of the target radiation source, thereby generating the first imaging data at the first distance position in the first direction.

[0034] S120. Control the first detector and the second detector to move separately in the first direction. When both the first detector and the second detector are at a second distance from the monitoring object, the monitoring object is imaged for the second time by the first detector and the second detector to obtain second imaging data in the first direction.

[0035] Specifically, after the first imaging is completed, the Compton camera system can control the first detector and the second detector to move synchronously along the first direction until both the first detector and the second detector are at the second distance from the monitoring object. Wherein, the second distance may also refer to the vertical distance preset between the imaging center of the detector and the geometric center of the monitoring object.

[0036] It should be noted that the second distance can be greater than the first distance or less than the first distance. When the second distance is less than the first distance, the operation of controlling the first detector and the second detector to move respectively in the first direction corresponds to controlling the first detector and the second detector to approach the monitoring object in the first direction. Specifically, after the first imaging, the first detector and the second detector can be controlled to move towards each other synchronously to ensure that the vertical distances between the two detectors and the center of the monitoring object decrease equally and synchronously. Exemplarily, when the first direction is the horizontal direction and the monitoring object is taken as the coordinate origin, if the first distance is 25 cm, the first detector is controlled to move 0.1 cm inward along the negative horizontal direction and the second detector is controlled to move 0.1 cm inward along the positive horizontal direction, so that the distances between both of them and the monitoring object are shortened to 24.9 cm, and this 24.9 cm can be used as the second distance. After the movement, the first detector and the second detector will be in positions where they are both 24.9 cm (the second distance) away from the monitoring object.

[0037] Relatively, when the second distance is greater than the first distance, the operation of controlling the first detector and the second detector to move respectively in the first direction corresponds to controlling the first detector and the second detector to move away from the monitoring object in the first direction. Specifically, after the first imaging is completed, the first detector and the second detector can be controlled to move away from each other synchronously to ensure that the vertical distances between the two detectors and the center of the monitoring object increase equally and synchronously. Exemplarily, when the first direction is the horizontal direction and the monitoring object is taken as the coordinate origin, if the first distance is 24.9 cm, the first detector is controlled to move 0.1 cm outward along the positive horizontal direction and the second detector is controlled to move 0.1 cm outward along the negative horizontal direction, so that the distances between both of them and the monitoring object are increased to 25 cm, and this 25 cm can be used as the second distance. After the movement, the first detector and the second detector will eventually be in positions where they are both 25 cm (the second distance) away from the monitoring object.

[0038] Furthermore, when the first detector and the second detector are both at the second distance from the monitoring object, the monitoring object is imaged for the second time by the first detector and the second detector to obtain second imaging data in the first direction.

[0039] Similarly, the gamma rays released by the monitoring object after being irradiated by the neutron beam are synchronously captured by the first detector and the second detector, and the corresponding Compton scattering events are recorded. Subsequently, the first detector and the second detector can perform event reconstruction based on the collected data to generate second imaging data at the second distance position in the first direction. Among them, the second imaging data can be three-dimensional imaging data containing the energy, position, and intensity information of the gamma ray events at the second distance position in the first direction.

[0040] S130. Monitor the boron concentration of the monitoring object based on the first imaging data and the second imaging data.

[0041] It should be noted that based on the characteristic that the imaging of a Compton camera forms a conical surface, when gamma events at multiple different depths are imaged simultaneously, since the radius of the bottom surface of the cone generated by deep events is large and the covered spatial range is wide, while the radius of the bottom surface of the cone generated by shallow events is small and the covered spatial range is relatively concentrated, there will be a situation where the conical surfaces of multiple events cross in space. However, since the reconstruction algorithm cannot distinguish points at different depths on the conical surface and will default that the possibility of each point on the conical surface is the same, when using the reconstruction algorithm to reconstruct the imaging result, the wide cones of a large number of deep events will overlap with the narrow cones of shallow events in the area close to the detector (near the Compton camera), resulting in a false increase in the signal density. Specifically, because the algorithm wrongly believes that the signal density in this overlapping area close to the detector is extremely high, a false hot spot, that is, an artifact, is reconstructed at this position, while the position of the real target radiation source (the monitored object) may be covered or blurred instead. This is called forward shift artifact or near-field artifact.

[0042] Furthermore, to overcome the artifact problem, the first imaging data and the second imaging data obtained by imaging at different distances can be utilized to analyze the trend of signal variation with distance, distinguish the real radiation source signal and the artifact signal, monitor the boron concentration of the monitored object, and obtain a high-precision boron concentration monitoring result.

[0043] Specifically, by comparing the first imaging data with the second imaging data and performing three-dimensional reconstruction analysis, when the real monitored object is close to the detector, its three-dimensional reconstruction position will relatively stably converge to a point (with a small movement amplitude and random or irregular directions). Correspondingly, for the artifact, when the detector is close, since the originally overlapping wide cone becomes narrower and the overlapping effect weakens, the false hot spot is pushed to its more real deep position. That is, the reconstruction position of the artifact will show an obvious reverse movement trend, that is, significantly moving away from the detector and towards a deeper direction. Further, by analyzing and comparing the information contained in the first imaging data and the second imaging data, the artifact signal can be analyzed and identified, and the imaging data can be corrected inversely, thereby significantly reducing the artifact error, restoring the spatial distribution of the real depth information, and finally obtaining a high-precision boron concentration monitoring result.

[0044] In the above embodiment, by moving the detector in the same direction and acquiring imaging data at different distances, the imaging error caused by near-field approximation or depth resolution limitation of the Compton camera at a single fixed distance is overcome, thereby improving the reliability of the imaging data. Finally, using the dynamic distance information contained in the two imaging data, on the premise of ensuring that the detection efficiency is at a relatively optimal level and the spatial resolution is good, the dynamic real-time boron concentration monitoring work of the monitored object is carried out, thereby improving the monitoring accuracy and finally obtaining a high-precision boron concentration monitoring result.

[0045] In some embodiments, please refer to the attached Figure 2 , and perform boron concentration monitoring on the monitoring object based on the first imaging data and the second imaging data, including: S210. Perform imaging trend analysis based on the first imaging data and the second imaging data to obtain imaging trend data.

[0046] Among them, the imaging trend data may refer to a convergence trend vector that quantifies the ratio of the signal depth change with the detector distance in the imaging data, that is, when the distance between the detector and the monitoring object changes, the vector of the imaging result converging to the real position. Exemplarily, the imaging trend data may include the moving direction and moving amplitude of each suspected target radiation source signal point to help distinguish the target radiation source from artifacts. Specifically, first, based on the first imaging data and the second imaging data, pair the signal points in the two sets of imaging data, that is, match the same gamma-ray event in the two sets of imaging data through energy and spatial proximity. Subsequently, calculate the depth change amount and distance change amount of each matched signal point, analyze the change law of its position, and obtain the convergence trend vector of the change direction, that is, the imaging trend data.

[0047] S220. Correct the first imaging data or the second imaging data based on the imaging trend data to obtain corrected imaging data, and use the corrected imaging data to perform boron concentration monitoring on the monitoring object.

[0048] Among them, the corrected imaging data may refer to high-precision three-dimensional imaging data obtained by performing dynamic error correction on the first imaging data or the second imaging data obtained from the original imaging. Specifically, due to the imaging characteristics of BNCT, when the detector approaches the monitoring object, its imaging accuracy will improve. Therefore, when the first distance is greater than the second distance, the accuracy of the second imaging data is usually higher than that of the first imaging data. At this time, the second imaging data can be updated and corrected based on the imaging trend data to obtain the corrected imaging data. On the contrary, when the first distance is less than the second distance, the accuracy of the first imaging data is usually higher than that of the second imaging data. At this time, the first imaging data can be updated and corrected based on the imaging trend data to obtain the corrected imaging data. Exemplarily, denote the first imaging data as I1 and the second imaging data as I2. Performing imaging trend analysis on I1 and I2 can obtain imaging trend data Q1. At this time, if the first distance is greater than the second distance, that is, the accuracy of I1 is lower than that of I2, then correct I2 using the imaging trend data Q1. On the contrary, if the first distance is less than the second distance, that is, the accuracy of I1 is higher than that of I2, then correct I1 using the imaging trend data Q1.

[0049] It should be noted that the case where the first distance is greater than the second distance is described. Since the three-dimensional reconstruction position of the real monitoring object converges to a point relatively stably (with a small movement amplitude and random or irregular direction) when the detector approaches. Correspondingly, when the detector approaches, the overlapping effect of the artifact weakens because the originally wide cone causing the overlap becomes narrower, and the false hot spot is pushed to its deeper and more real position. That is, the reconstruction position of the artifact shows an obvious reverse movement trend. Therefore, before correcting the first imaging data or the second imaging data based on the imaging trend data, the signal points included in the imaging data can be classified using the imaging trend data to determine whether it is an artifact or a target radiation source for subsequent processing.

[0050] Further, after classifying and judging the signal points in the imaging data as artifacts and target radiation sources, the original imaging data can be updated and corrected. Specifically, for the signal points determined to be artifacts, reverse displacement processing can be performed to push the mispositioned forward signal back to the depth; for the signal points determined to be target radiation sources, their original position information is retained. After finally performing the above update and correction processing on all the signal points included in the imaging data, the corrected imaging data is obtained. Further, based on the corrected imaging data, combined with the gamma ray intensity and energy information collected by each detector, the boron concentration of the monitoring object is inversely deduced to obtain a high-precision boron concentration monitoring result.

[0051] In the above embodiment, by using the first imaging data and the second imaging data for imaging trend analysis, ratio vector data including signal depth changes is generated to distinguish the real radiation source area from the artifacts. Further, the original imaging data is corrected using the imaging trend data to eliminate the interference of the artifacts and retain the original position of the target radiation source signal. Based on the corrected imaging data, the boron concentration of the monitoring object is accurately inversely deduced, thereby significantly improving the accuracy of the monitoring result. Finally, it can effectively improve the accuracy of boron concentration monitoring, reduce misjudgment caused by imaging errors, and provide reliable data support for boron neutron capture therapy.

[0052] In some embodiments, the Compton camera system further includes a second Compton camera group. The second Compton camera group includes a third detector and a fourth detector that are opposite and parallel to each other in the second direction; the first direction is perpendicular to the second direction. Please refer to the appendix Figure 3a , and the method further includes: S310. During the first imaging, both the third detector and the fourth detector are at a first distance from the monitoring object, and the monitoring object is imaged by the third detector and the fourth detector to obtain third imaging data in the second direction.

[0053] It should be understood that since the reconstructed cone obtained by Compton camera imaging is in the shape of being narrow at the top and wide at the bottom, even if one or more sets of parallel Compton cameras are set, the detection directions are single-angle, resulting in a large error in the depth direction of the obtained three-dimensional imaging. Therefore, in order to better eliminate the depth error, the Compton camera system may further include a second Compton camera group 20, such as Figure 3b As shown, the Compton camera system arranged around the monitoring object 101 further includes a second Compton camera group 20, which includes a third detector 201 and a fourth detector 203 that are opposite and parallel to each other in the second direction. Optionally, the structures of the third detector 201 and the fourth detector 203 may also be as Figure 1c shown.

[0054] Specifically, to further reduce the imaging error in the depth direction, the third detector 201 and the fourth detector 203 may also be symmetrically arranged on both sides of the monitoring object 101 respectively. However, different from the first detector 103 and the second detector 105, the third detector 201 and the fourth detector 203 are opposite and parallel to each other along the second direction. Among them, the second direction may be a reference direction determined when arranging the detectors of the second Compton camera group 20, and the first direction and the second direction may tend to be perpendicular. Exemplarily, please continue to refer to Figure 3b , taking the monitoring object as the origin, taking the first direction as the horizontal direction, the second direction may be taken as the vertical direction. At this time, the third detector 201 may be arranged on one side of the vertical positive direction; correspondingly, the fourth detector 203 may be arranged on one side of the vertical negative direction to provide detection data with an opposite viewing angle to the third detector 201.

[0055] Furthermore, during the first imaging, in addition to imaging the monitoring object through the first detector and the second detector, the third detector and the fourth detector may also be used to image the monitoring object to obtain third imaging data in the second direction.

[0056] Among them, the third imaging data can be three-dimensional imaging data including the energy, position, and intensity information of gamma-ray events at the first distance position in the second direction. Specifically, before the first imaging, the vertical distances between the imaging centers of the first Compton camera group (the first detector and the second detector) and the second Compton camera group (the third detector and the fourth detector) and the geometric center of the monitoring object can be adjusted to the first distance to ensure that the two detector groups are symmetrically arranged at equal distances in the first direction and the second direction. Subsequently, during imaging, all detectors of the first Compton camera group and the second Compton camera group are triggered simultaneously, so that the first detector, the second detector, the third detector, and the fourth detector synchronously start the data acquisition operation and perform three-dimensional imaging. Finally, not only can the first imaging data at the first distance position in the first direction be obtained, but also the third imaging data at the first distance position in the second direction can be obtained by using the two detectors of the second Compton camera group.

[0057] S320. During the second imaging, the third detector and the fourth detector are both at a second distance from the monitoring object, and the monitoring object is imaged by the third detector and the fourth detector to obtain the fourth imaging data in the second direction.

[0058] Similarly, before the second imaging, the vertical distances between the imaging centers of the first Compton camera group and the second Compton camera group and the geometric center of the monitoring object can be adjusted to the second distance to ensure that the two detector groups are symmetrically arranged at equal distances in the first direction and the second direction. Subsequently, during imaging, all detectors are triggered simultaneously to synchronously start the data acquisition operation and perform three-dimensional imaging. Finally, the second imaging data at the second distance position in the first direction and the fourth imaging data at the second distance position in the second direction can also be obtained. Among them, the fourth imaging data can be three-dimensional imaging data including the energy, position, and intensity information of gamma-ray events at the second distance position in the second direction.

[0059] Correspondingly, boron concentration monitoring of the monitoring object based on the first imaging data and the second imaging data includes: S330. Boron concentration monitoring of the monitoring object is performed based on the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data.

[0060] Specifically, based on the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data, using the geometric constraints of its two sets of orthogonal detectors, the conical surface of a single event is blurred and compressed into a spatial intersection point. Exemplarily, the first imaging data and the second imaging data obtained in the first direction can be superimposed on the third imaging data and the fourth imaging data obtained in the second direction, and the double-cone intersection point of each gamma photon event can be calculated through a three-dimensional reconstruction algorithm to identify and correct artifacts, thereby accurately positioning the specific position of the target radiation source.

[0061] In the above embodiments, by arranging two sets of Compton camera groups that tend to be orthogonal and synchronously acquiring data at different distances, complementary imaging data in multiple angles and dimensions is achieved. Three-dimensional reconstruction is performed using the first and second imaging data in the horizontal direction and the third and fourth imaging data in the vertical direction, compressing the conical surface blur of a single event into a spatial intersection point, significantly suppressing the depth error and artifacts caused by the imaging characteristics of the Compton camera. Finally, based on the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data, real-time and high-resolution monitoring of boron concentration is achieved, providing reliable online dose assessment support for BNCT treatment.

[0062] In some embodiments, the first Compton camera group and the second Compton camera group move closer to the monitoring object. After moving to the allowable distance threshold, the first Compton camera group and the second Compton camera group move away from the monitoring object.

[0063] Among them, the allowable distance threshold may refer to the minimum safe distance maintained between the detector and the monitoring object during the dynamic movement of the Compton camera system. The allowable distance threshold can be set based on the imaging accuracy requirements and physical constraints to balance imaging accuracy and equipment safety. Exemplarily, if the first distance between the detector and the monitoring object is 25 cm, the allowable distance threshold can be taken as 20 cm. That is to say, when the distance between the detector and the monitoring object gradually decreases from 25 cm (the first distance) to 20 cm (the allowable distance threshold), the system can trigger a reverse movement operation away from the monitoring object, so that the distance between the detector and the monitoring object gradually increases from 20 cm.

[0064] Optionally, when the detector moves from the allowable distance threshold to the first distance again, the above movement process can be repeated to form a cycle of "close - away - close" to continuously update the data. The trend obtained previously can also be applied to the next movement and reconstruction process, thereby providing a dynamic data chain for imaging trend analysis, better stripping the artifact signal, and meeting the requirements of real-time high-precision boron concentration monitoring.

[0065] In the above embodiments, since the conical surface reconstruction error decreases and the position of the artifact signal significantly moves backward when the detector approaches the monitoring object; by setting the allowable distance threshold and controlling the Compton camera group to move cyclically between the first distance and the threshold, dynamic data acquisition and error correction are achieved by analyzing the imaging data at different distances multiple times. Thus, while ensuring the safe distance of the equipment, the high-precision and real-time monitoring requirements of boron concentration in BNCT treatment are met.

[0066] In some embodiments, the first detector, the second detector, the third detector, and the fourth detector move synchronously.

[0067] Specifically, to ensure the high-precision requirements for boron concentration monitoring and reduce the influence of interference variables introduced by asynchronous movement of the detectors, the first to fourth detectors can be controlled to move collaboratively in the first direction and the second direction at the same time and at the same rate, so as to ensure that the distances between all detectors and the center of the monitoring object change synchronously, and to ensure that the number of particles collected each time is comparable. At the same time, it is necessary to avoid the distance difference caused by asynchronous movement, which affects the comparability of multi-angle data.

[0068] Furthermore, controlling the first detector and the second detector to move separately in the first direction, and controlling the third detector and the fourth detector to move separately in the second direction, may include: While the first detector and the second detector move towards each other at a preset rate in the first direction, the third detector and the fourth detector also move towards each other at the same preset rate in the second direction.

[0069] Among them, the preset rate can refer to the fixed speed when each detector moves. It needs to meet the continuity requirements for the acquisition of gamma-ray events by the detector during the movement, and at the same time, it is necessary to avoid the risk of mechanical vibration or collision caused by rapid movement. Exemplarily, to balance the requirements of real-time performance, accuracy and safety, the preset rate of the detector can be set to move 0.1 cm every 10 seconds.

[0070] Specifically, during imaging, all detectors of the first Compton camera group and the second Compton camera group can be triggered simultaneously, that is, the first detector and the second detector move towards each other at a preset rate in the first direction to start the data acquisition operation and perform three-dimensional imaging, while the third detector and the fourth detector also move towards each other at the same preset rate in the second direction.

[0071] Exemplarily, taking the monitoring object as the origin, the first direction is taken as the horizontal direction, the second direction is taken as the vertical direction, and the preset rate is taken as 0.1 cm / s. In the case of moving towards each other, the first detector can move gradually towards the monitoring object along the negative horizontal direction, the second detector can move gradually towards the monitoring object along the positive horizontal direction, and their moving rates are both 0.1 cm / s. At the same time, the third detector can move gradually towards the monitoring object along the negative vertical direction, and the second detector can move gradually towards the monitoring object along the positive vertical direction, and their moving rates are also both 0.1 cm / s.

[0072] Or while the first detector and the second detector move away from each other at a preset rate in the first direction, the third detector and the fourth detector also move away from each other at the same preset rate in the second direction.

[0073] Similarly, still taking the monitoring object as the origin, please refer to Figure 3c, the first direction is taken as the horizontal direction, the second direction is taken as the vertical direction, and the preset rate is taken as 0.1 cm / s. In the case of moving away from each other, the first detector can move away from the monitoring object step by step along the positive horizontal direction, the second detector can move away from the monitoring object step by step along the negative horizontal direction, and their moving rates are both 0.1 cm / s. At the same time, the third detector can move away from the monitoring object step by step along the positive vertical direction, the second detector can move away from the monitoring object step by step along the negative vertical direction, and their moving rates are also both 0.1 cm / s.

[0074] In the above embodiment, by controlling multiple detectors to move synchronously towards or away from each other in different directions at the same preset rate, it is ensured that the distances between all detectors and the monitoring object change synchronously, thereby eliminating the multi-angle data deviation caused by asynchronous movement. In addition, the synchronous movement strategy combined with real-time data acquisition significantly reduces the depth error of the Compton camera due to the conical surface imaging characteristics by dynamically adjusting the detector positions, while avoiding the risk of mechanical vibration, and finally meets the high-precision and real-time requirements of boron concentration monitoring.

[0075] In some embodiments, please refer to the appendix Figure 4 , if the second distance is less than the first distance, boron concentration monitoring of the monitoring object is performed based on the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data, including: S410. Perform imaging trend analysis based on the first imaging data and the second imaging data to obtain first imaging trend data.

[0076] Among them, the first imaging trend data can be trend vector data used to quantify the ratio of signal depth to detector distance change in the imaging data in the first direction. Specifically, through imaging trend analysis, by comparing the depth changes of corresponding signal points in the imaging data at different distances (the first distance and the second distance) in the first direction, and analyzing the law of its change with the detector distance, the first imaging trend data is obtained.

[0077] S420. Use the first imaging trend data to correct the second imaging data to obtain first corrected imaging data.

[0078] It can be understood that if the second distance is less than the first distance, correspondingly, the accuracy of the second imaging data will also be higher than that of the first imaging data. Therefore, the first imaging trend data can be used to update and correct the second imaging data with relatively high accuracy. Exemplarily, first, artifact and target radiation source judgment can be performed on the signal points included in the second imaging data based on the first imaging trend data. Subsequently, reverse displacement processing can be performed on all signal points determined to be artifacts to push the misforwarded signals back to the depth, while retaining the original position information of all signal points determined to be target radiation sources, thereby obtaining the first corrected imaging data.

[0079] It should be noted that if the second distance is greater than the first distance, the first imaging data can be corrected using the first imaging trend data to obtain the first corrected imaging data.

[0080] S430. Perform imaging trend analysis based on the third imaging data and the fourth imaging data to obtain the second imaging trend data.

[0081] Among them, the second imaging trend data can be trend vector data used to quantify the ratio of signal depth change with the detector distance in the imaging data in the second direction. Specifically, through imaging trend analysis, by comparing the depth changes of corresponding signal points in the imaging data at different distances in the second direction, the law of its change with the detector distance is analyzed to obtain the second imaging trend data.

[0082] S440. Correct the fourth imaging data using the second imaging trend data to obtain the second corrected imaging data.

[0083] Similarly, if the second distance is less than the first distance, correspondingly, the accuracy of the fourth imaging data is also higher than that of the third imaging data. Therefore, the second imaging trend data can be used to update and correct the fourth imaging data with relatively high accuracy. Exemplarily, first, signal judgment is performed on the signal points included in the fourth imaging data based on the second imaging trend data, and then reverse displacement processing is performed on all signal points determined to be artifacts, while retaining the original position information of all signal points determined to be the target radiation source, thereby obtaining the second corrected imaging data.

[0084] It should be noted that if the second distance is greater than the first distance, the third imaging data can be corrected using the second imaging trend data to obtain the first corrected imaging data.

[0085] S450. Monitor the boron concentration of the monitored object based on the first corrected imaging data and the second corrected imaging data.

[0086] Due to the imaging characteristics of the Compton camera, there is a large error in the depth direction of the three-dimensional reconstruction imaging at a single angle. Therefore, two groups of Compton camera sets are arranged symmetrically along two directions. The detectors included in each group are parallel to each other within the group and perpendicular to each other between the groups. Subsequently, synchronous imaging operations are performed using these four detectors respectively, and the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data are obtained. Then, during reconstruction, imaging trend analysis and correction are performed on the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data in groups, and the first corrected imaging data and the second corrected imaging data in two directions are obtained to monitor the boron concentration of the monitoring object. Further, when monitoring the boron concentration, the corrected imaging data in two directions can be superimposed, and residual artifacts can be further excluded through spatial intersection verification. Then, based on the gamma-ray intensity and energy information collected by each detector, a high-precision boron concentration monitoring result is finally obtained.

[0087] Optionally, since the first Compton camera set and the second Compton camera set move closer to or away from the monitoring object at the same preset rate, the four detectors can perform an imaging operation every time they move a certain distance. That is to say, the two groups of detectors can first perform an imaging operation at the first distance, then move from the first distance to the second distance and perform an imaging operation again, and then move from the second distance to the third distance and can also perform an imaging operation until they move to the allowable distance threshold. Correspondingly, when monitoring the boron concentration of the monitoring object, it is not limited to the first imaging data, the third imaging data obtained from the first imaging, and the second imaging data, the fourth imaging data obtained from the second imaging, but can perform step-by-step trend analysis and imaging update correction based on multiple imaging data obtained from multiple imaging operations, and finally obtain a higher-precision boron concentration monitoring result.

[0088] It should be noted that as the detector gradually approaches the radiation source area (monitoring object) at a constant rate, the accuracy of each obtained imaging result will also gradually increase. This is because when the Compton camera is closer to the radiation source area, the radius of the bottom surface of the reconstruction cone reconstructed by each Compton event will be smaller, making the reconstruction cone closer to the ray emitted from the vertex (that is, the reconstruction cone becomes narrower and more concentrated). Therefore, every time the detector approaches the radiation source area, the reconstruction result will be closer to the position of the target radiation source.

[0089] Furthermore, a cyclic operation of moving and imaging multiple times (such as gradually approaching from 25 cm to 20 cm and then gradually moving away in the reverse direction from 20 cm back to 25 cm) can be utilized to make the reconstruction results after each approach converge further to the position of the real radiation source. Based on this dynamic process, the trend of the signal position changing with distance can be analyzed. To achieve real-time boron concentration monitoring, Compton cameras in four directions can be controlled to collect data simultaneously. To ensure the accuracy of the measurement in the radiation source area, the Compton cameras in four directions need to move and image synchronously, and ensure that the time intervals of each movement are the same to ensure that the number of particles collected each time is approximately the same. Then, an imaging trend analysis is performed on the imaging results obtained each time approaching to determine the imaging trend data. In addition, the imaging trend data from the previous time can be used to guide and optimize the movement strategy, imaging, and reconstruction operations of the detector next time. In this way, iterative accuracy improvement is continuously achieved, making the finally obtained results more and more accurate.

[0090] Exemplarily, taking the first distance as 25 cm and the preset rate as moving 0.1 cm every 10 seconds as an example, if imaging is performed once every 10 s, then the first imaging can obtain the imaging data I11 in the first direction and the imaging data I12 in the second direction at 25 cm, the second imaging can obtain the imaging data I21 in the first direction and the imaging data I22 in the second direction at 24.9 cm, and the third imaging can obtain the imaging data I31 in the first direction and the imaging data I32 in the second direction at 24.8 cm, and so on.

[0091] Furthermore, when performing boron concentration monitoring, an imaging trend analysis can be first performed on I11 and I12 at 25 cm and I21 and I22 at 24.9 cm to obtain the trend data Q1. Then, Q1 is used to correct the two imaging data at 24.9 cm to obtain I1, and the boron concentration of the monitoring object is directly monitored based on I1. It is also possible to perform an imaging trend analysis on I21 and I22 at 24.9 cm and I31 and I32 at 24.8 cm after obtaining the imaging trend data Q1 to obtain the trend data Q2, and use Q1 and Q2 together to correct the two imaging data at 24.8 cm to obtain more accurate I2, and then monitor the boron concentration of the monitoring object based on the more accurate I2.

[0092] Similarly, by performing step-by-step trend analysis and imaging update correction according to the above scheme, corrected imaging data with relatively high accuracy can ultimately be obtained to perform real-time and high-precision boron concentration monitoring on the monitoring object. In the above embodiment, by analyzing the trend of the signal position changing with distance through imaging data at different distances and performing correction processing on it, the depth error is significantly reduced. And multi-dimensional verification of data in the horizontal and vertical directions is adopted to further eliminate residual artifacts and improve the spatial resolution of three-dimensional imaging. Finally, by using the cyclic movement strategy and the step-by-step correction algorithm, through the cyclic movement strategy of synchronous movement of two orthogonally arranged Compton cameras and the step-by-step correction algorithm for collecting multi-distance imaging data for dynamic trend analysis, the high-precision imaging data is continuously updated to meet the on-line real-time monitoring requirements of boron concentration in BNCT treatment, and real-time and high-precision boron concentration monitoring is performed on the monitoring object.

[0093] The embodiment of this specification also provides a boron concentration monitoring device 500, as Figure 5 shown, including a first imaging module 510, a second imaging module 520, and a concentration monitoring module 530, where: The first imaging module 510 is configured to, when the first detector and the second detector are both at a first distance from the monitoring object, perform a first imaging on the monitoring object through the first detector and the second detector to obtain first imaging data in a first direction.

[0094] The second imaging module 520 is configured to control the first detector and the second detector to move respectively in the first direction. When the first detector and the second detector are both at a second distance from the monitoring object, perform a second imaging on the monitoring object through the first detector and the second detector to obtain second imaging data in the first direction.

[0095] The concentration monitoring module 530 is configured to perform boron concentration monitoring on the monitoring object based on the first imaging data and the second imaging data.

[0096] In some embodiments, the second imaging module 520 is further configured to control the first detector and the second detector to move respectively in the first direction, including: controlling the first detector and the second detector to approach the monitoring object in the first direction and move to a position at a second distance from the monitoring object; where the second distance is less than the first distance; or controlling the first detector and the second detector to move away from the monitoring object in the first direction and move to a position at a second distance from the monitoring object; where the second distance is greater than the first distance.

[0097] In some embodiments, the concentration monitoring module 530 is further configured to perform boron concentration monitoring on the monitoring object based on the first imaging data and the second imaging data, including: performing imaging trend analysis based on the first imaging data and the second imaging data to obtain imaging trend data; correcting the first imaging data or the second imaging data based on the imaging trend data to obtain corrected imaging data, so as to perform boron concentration monitoring on the monitoring object by using the corrected imaging data.

[0098] In some embodiments, the Compton camera system further includes a second Compton camera group, and the second Compton camera group includes a third detector and a fourth detector that are opposite and parallel to each other in the second direction; the first direction and the second direction tend to be perpendicular; a boron concentration monitoring device 500 further includes a multiple imaging module, configured to, when performing the first imaging, control the third detector and the fourth detector to be both at a first distance from the monitoring object, and image the monitoring object through the third detector and the fourth detector to obtain third imaging data in the second direction; when performing the second imaging, the third detector and the fourth detector are both at a second distance from the monitoring object, and image the monitoring object through the third detector and the fourth detector to obtain fourth imaging data in the second direction; correspondingly, performing boron concentration monitoring on the monitoring object based on the first imaging data and the second imaging data includes: performing boron concentration monitoring on the monitoring object based on the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data.

[0099] In some embodiments, the multiple imaging module is further configured to control the first Compton camera group and the second Compton camera group to move closer to the monitoring object, and after moving to the allowable distance threshold, control the first Compton camera group and the second Compton camera group to move away from the monitoring object.

[0100] In some embodiments, the multiple imaging module is further configured to control the first detector, the second detector, the third detector, and the fourth detector to move synchronously.

[0101] In some embodiments, the multiple imaging module is further configured to control the first detector and the second detector to move towards each other at a preset rate in the first direction, and at the same time, the third detector and the fourth detector move towards each other at the same preset rate in the second direction; or control the first detector and the second detector to move away from each other at a preset rate in the first direction, and at the same time, the third detector and the fourth detector move away from each other at the same preset rate in the second direction.

[0102] In some embodiments, if the second distance is less than the first distance, the concentration monitoring module 530 is further configured to monitor the boron concentration of the monitoring object based on the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data, including: performing imaging trend analysis based on the first imaging data and the second imaging data to obtain first imaging trend data; using the first imaging trend data to correct the second imaging data to obtain first corrected imaging data; performing imaging trend analysis based on the third imaging data and the fourth imaging data to obtain second imaging trend data; using the second imaging trend data to correct the fourth imaging data to obtain second corrected imaging data; and monitoring the boron concentration of the monitoring object according to the first corrected imaging data and the second corrected imaging data.

[0103] For the specific limitations of a boron concentration monitoring device, reference may be made to the limitations of a boron concentration monitoring method described above, which will not be elaborated here. Each module in the above boron concentration monitoring device can be implemented in whole or in part by software, hardware, and their combination. Each of the above modules can be embedded in or independent of a processor in a computer device in the form of hardware, or stored in a memory in the computer device in the form of software, so that the processor can call and execute the operations corresponding to the above modules.

[0104] The boron concentration monitoring device in this embodiment is presented in the form of functional units. Here, the unit refers to an ASIC (Application Specific Integrated Circuit) circuit, a processor and a memory that execute one or more software or fixed programs, and / or other devices that can provide the above functions.

[0105] The embodiment of the present application further provides a computer device, which may be a terminal, and its internal structure diagram may be as Figure 6As shown in the figure. The computer device includes a processor, a memory, a communication interface, a display screen, and an input device connected through a system bus. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and computer programs. The internal memory provides an environment for the operation of the operating system and computer programs in the non-volatile storage medium. The communication interface of the computer device is used to communicate with external terminals in a wired or wireless manner, and the wireless manner can be achieved through WIFI, mobile cellular networks, NFC (Near Field Communication), or other technologies. When the computer program is executed by the processor, it implements a boron concentration monitoring method. The display screen of the computer device can be a liquid crystal display screen or an electronic ink display screen, and the input device of the computer device can be a touch layer covering the display screen, or a button, trackball, or touchpad provided on the housing of the computer device, or an external keyboard, touchpad, or mouse, etc.

[0106] Those skilled in the art can understand that Figure 6 the structure shown in the figure is only a block diagram of some structures related to the solution of this application, and does not constitute a limitation on the computer device to which the solution of this application is applied. The specific computer device may include more or fewer components than those shown in the figure, or combine some components, or have different component arrangements.

[0107] The embodiment of this application also provides a computer-readable storage medium. The method according to the embodiment of this application can be implemented in hardware, firmware, or be implemented as computer code that can be recorded on a storage medium, or be implemented as computer code that is originally stored in a remote storage medium or a non-transitory machine-readable storage medium and downloaded through a network and will be stored in a local storage medium, so that the method described herein can be processed by such software stored on a storage medium using a general-purpose computer, a dedicated processor, or programmable or dedicated hardware. Among them, the storage medium can be a magnetic disk, an optical disk, a read-only memory, a random access memory, a flash memory, a hard disk, or a solid-state drive, etc.; further, the storage medium can also include a combination of the above types of memories. It can be understood that a computer, a processor, a microprocessor controller, or programmable hardware includes a storage component that can store or receive software or computer code. When the software or computer code is accessed and executed by the computer, the processor, or the hardware, the method shown in the above embodiment is implemented.

[0108] The embodiment of this application provides a computer program product. The computer program product includes computer instructions, and the computer instructions are stored in a computer-readable storage medium. The processor of the computer device reads the computer instructions from the computer-readable storage medium, and the processor executes the computer instructions, so that the computer device executes the method of any embodiment of this application.

[0109] Those skilled in the art should understand that the embodiments of the present application can be provided as a method, a system, or a computer program product. Therefore, the present application can take the form of a completely hardware embodiment, a completely software embodiment, or an embodiment combining software and hardware aspects. Moreover, the present application can take the form of a computer program product implemented on one or more computer-usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) that contain computer-usable program code.

[0110] The present application is described with reference to the flowcharts and / or block diagrams of methods, apparatuses (systems), and computer program products according to the embodiments of the present application. It should be understood that each flow and / or block in the flowchart and / or block diagram, and the combination of flows and / or blocks in the flowchart and / or block diagram, can be realized by computer program instructions. These computer program instructions can be provided to the processor of a general-purpose computer, a special-purpose computer, an embedded processor, or other programmable data processing devices to generate a machine, such that the instructions executed by the processor of the computer or other programmable data processing devices produce a device for realizing the functions specified in one or more flows in the flowchart and / or one or more blocks in the block diagram.

[0111] These computer program instructions can also be stored in a computer-readable memory that can direct a computer or other programmable data processing device to work in a specific manner, such that the instructions stored in the computer-readable memory produce a manufactured article including an instruction device that realizes the functions specified in one or more flows in the flowchart and / or one or more blocks in the block diagram.

[0112] These computer program instructions can also be loaded onto a computer or other programmable data processing device, such that a series of operation steps are executed on the computer or other programmable device to produce a computer-implemented process, so that the instructions executed on the computer or other programmable device provide steps for realizing the functions specified in one or more flows in the flowchart and / or one or more blocks in the block diagram.

[0113] In the description of this specification, the descriptions referring to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples", etc. mean that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0114] In addition, the terms "first" and "second" are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In the description of this application, "a plurality of" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0115] It should also be noted that the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, such that a process, method, commodity or device comprising a series of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, commodity or device. Without further limitation, an element defined by the statement "comprising an..." does not exclude the presence of additional identical elements in the process, method, commodity or device comprising the element.

[0116] Each embodiment in this specification is described in a progressive manner. For the same or similar parts among the embodiments, reference can be made to each other. Each embodiment focuses on the differences from other embodiments. Since it is basically similar to the method embodiment, the description is relatively simple, and for the relevant parts, reference can be made to the description of the method embodiment.

[0117] The above description is only for the embodiments of this application and is not intended to limit this application. For those skilled in the art, various changes and modifications can be made to this application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of this application shall be included within the scope of the claims of this application.

[0118] Although the embodiments of this application are described in conjunction with the accompanying drawings, those skilled in the art can make various modifications and variations without departing from the spirit and scope of this application, and such modifications and variations fall within the scope defined by the appended claims.

Claims

1. A method for monitoring boron concentration, characterized in that, Applied to a Compton camera system, the Compton camera system includes a first Compton camera group, and the first Compton camera group includes a first detector and a second detector that are opposite and parallel to each other in a first direction; the method includes: When the first detector and the second detector are both at a first distance from the monitoring object, the first detector and the second detector are used to perform a first imaging on the monitoring object to obtain first imaging data in the first direction; Control the first detector and the second detector to move respectively in the first direction. When the first detector and the second detector are both at a second distance from the monitoring object, the first detector and the second detector are used to perform a second imaging on the monitoring object to obtain second imaging data in the first direction; Based on the first imaging data and the second imaging data, perform boron concentration monitoring on the monitoring object.

2. The method according to claim 1, characterized in that, The controlling the first detector and the second detector to move respectively in the first direction includes: Control the first detector and the second detector to approach the monitoring object in the first direction and move to a position where they are both at the second distance from the monitoring object; wherein, the second distance is less than the first distance; or Control the first detector and the second detector to move away from the monitoring object in the first direction and move to a position where they are both at the second distance from the monitoring object; wherein, the second distance is greater than the first distance.

3. The method according to claim 1, characterized in that The performing boron concentration monitoring on the monitoring object based on the first imaging data and the second imaging data includes: Perform imaging trend analysis based on the first imaging data and the second imaging data to obtain imaging trend data; Based on the imaging trend data, correct the first imaging data or the second imaging data to obtain corrected imaging data, so as to perform boron concentration monitoring on the monitoring object by using the corrected imaging data.

4. The method according to claim 1 or 2, characterized in that, The Compton camera system further includes a second Compton camera group, and the second Compton camera group includes a third detector and a fourth detector that are opposite and parallel to each other in a second direction; The first direction and the second direction tend to be perpendicular; the method further includes: During the first imaging, the third detector and the fourth detector are both at the first distance from the monitoring object, and the third detector and the fourth detector are used to perform imaging on the monitoring object to obtain third imaging data in the second direction; During the second imaging, the third detector and the fourth detector are both at the second distance from the monitoring object, and the third detector and the fourth detector are used to perform imaging on the monitoring object to obtain fourth imaging data in the second direction; Correspondingly, the performing boron concentration monitoring on the monitoring object based on the first imaging data and the second imaging data includes: Perform boron concentration monitoring on the monitoring object based on the first imaging data, the second imaging data, the third imaging data and the fourth imaging data.

5. The method according to claim 4, characterized in that, The first Compton camera group and the second Compton camera group move closer to the monitoring object. After moving to a permitted distance threshold, the first Compton camera group and the second Compton camera group move away from the monitoring object.

6. The method according to claim 5, characterized in that, The first detector, the second detector, the third detector, and the fourth detector move synchronously.

7. The method according to claim 6, wherein While the first detector and the second detector move towards each other at a preset rate in the first direction, the third detector and the fourth detector also move towards each other at the preset rate in the second direction; Or While the first detector and the second detector move away from each other at a preset rate in the first direction, the third detector and the fourth detector also move away from each other at the preset rate in the second direction.

8. The method according to claim 4, wherein If the second distance is less than the first distance, the boron concentration monitoring of the monitoring object based on the first imaging data, the second imaging data, the third imaging data, and the fourth imaging data includes: Performing imaging trend analysis based on the first imaging data and the second imaging data to obtain first imaging trend data; Using the first imaging trend data to correct the second imaging data to obtain first corrected imaging data; Performing imaging trend analysis based on the third imaging data and the fourth imaging data to obtain second imaging trend data; Using the second imaging trend data to correct the fourth imaging data to obtain second corrected imaging data; Performing boron concentration monitoring of the monitoring object according to the first corrected imaging data and the second corrected imaging data.

9. A computer device, characterized in that, Including: A memory and a processor, which are communicatively connected to each other. The memory stores computer instructions, and the processor executes the computer instructions to execute the method according to any one of claims 1 to 8.

10. A computer-readable storage medium, characterized in that, Computer instructions are stored on the computer-readable storage medium, and the computer instructions are used to cause a computer to execute the method according to any one of claims 1 to 8.

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