A transparent and visual antibacterial wound dressing and its preparation method

Abstract

This invention discloses a transparent and visualized antibacterial wound dressing and its preparation method. The dressing comprises a backing layer, a high water-permeable medical pressure-sensitive adhesive layer, a water-absorbing resin layer, and a release layer stacked longitudinally. The backing layer, the high water-permeable medical pressure-sensitive adhesive layer, and the release layer all have the same area, while the area of ​​the water-absorbing resin layer is smaller than that of the high water-permeable medical pressure-sensitive adhesive layer. All three layers are transparent. Chitosan quaternary ammonium salt is bonded to the side of the water-absorbing resin layer facing the release layer using a water-soluble adhesive. This invention introduces chitosan quaternary ammonium salt onto the water-absorbing resin layer, achieving antibacterial and wound exudate absorption effects. Simultaneously, the overall transparency of the dressing facilitates observation of wound healing.

Description

Technical Field

[0001] This invention relates to the field of medical supplies, and in particular to a transparent, visual antibacterial wound dressing and its preparation method. Background Technology

[0002] When a patient has an open wound, there is usually persistent wound exudate. To keep the wound dry, absorbent materials are needed to remove the exudate. Traditionally, gauze is used to absorb wound exudate, and it is secured to the wound with medical tape. However, gauze is often made of opaque material, and when it is necessary to check the wound healing, the medical tape and gauze need to be torn apart, increasing the workload of medical staff.

[0003] With advancements in medical technology, more comfortable wound exudate-absorbing dressings have emerged on the market. For example, Chinese patent CN219148204U discloses an absorbent silicone gel dressing comprising a release layer, a composite layer, and a backing layer. The composite layer is composed of a silicone gel perforated layer with uniformly distributed textures and a hydrocolloid perforated layer. The adhesiveness and absorbency of the hydrocolloid enhance the dressing's adhesion and provide some exudate absorption. However, the aforementioned silicone gel dressing may have the following problems: 1. Neither the hydrocolloid nor the silicone gel has antibacterial properties; if not regularly disinfected and replaced, it can affect wound healing. 2. The hydrocolloid's adhesiveness and absorbency, coming into direct contact with the wound, can cause pain when the dressing is removed due to its adhesion to the wound.

[0004] In view of this, the present invention proposes a transparent and visual antibacterial wound dressing and its preparation method to solve the above problems. Summary of the Invention

[0005] To overcome the shortcomings of the above-mentioned technologies, this invention provides a transparent and visual antibacterial wound dressing. Chitosan quaternary ammonium salt is introduced into the absorbent resin layer to achieve the effects of antibacterial and wound exudate absorption. At the same time, the dressing is transparent throughout, making it easy to observe the wound healing process.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A transparent and visible antibacterial wound dressing includes a backing layer, a high water-permeable medical pressure-sensitive adhesive layer, a water-absorbing resin layer, and a release layer stacked longitudinally. The backing layer, the high water-permeable medical pressure-sensitive adhesive layer, and the release layer all have the same area, while the area of ​​the water-absorbing resin layer is smaller than that of the high water-permeable medical pressure-sensitive adhesive layer. All three layers are transparent. Chitosan quaternary ammonium salt is bonded to the side of the water-absorbing resin layer facing the release layer by a water-soluble adhesive.

[0008] Preferably, the water-soluble adhesive is a water-soluble starch adhesive.

[0009] Preferably, the thickness of the water-absorbing resin layer is 10 to 100 μm, and the water-absorbing volume of the water-absorbing resin layer is not less than 20 times its own volume.

[0010] Preferably, the amount of chitosan quaternary ammonium salt added is 5-50 g / m³. 2 .

[0011] Preferably, the thickness of the high water-permeable medical pressure-sensitive adhesive layer is 20–40 μm, and the water vapor permeability of the high water-permeable medical pressure-sensitive adhesive layer is greater than 3000 g / m² within 24 hours. 2 .

[0012] Preferably, the backing layer is a polyurethane film layer.

[0013] Preferably, the thickness of the polyurethane film layer is 10–50 μm, and the water vapor permeability of the backing layer is greater than 3000 g / m² within 24 hours. 2 .

[0014] Preferably, the water-absorbing resin layer is located at the center of the high water-permeable medical pressure-sensitive adhesive layer.

[0015] To overcome the shortcomings of the above-mentioned technologies, this invention also provides a method for preparing a transparent and visual antibacterial wound dressing, comprising the following steps:

[0016] Step 1: Coat the release layer with high water permeability medical pressure-sensitive adhesive, and dry to form a high water permeability medical pressure-sensitive adhesive layer;

[0017] Step 2: Press the backing layer onto the high water permeability medical pressure-sensitive adhesive layer;

[0018] Step 3: Coat one side of the absorbent resin layer with a starch adhesive solution, and before the starch adhesive solution dries, evenly sprinkle chitosan quaternary ammonium salt powder onto the absorbent resin layer. After drying, the chitosan quaternary ammonium salt adheres to the absorbent resin layer.

[0019] Step 4: Tear off the release layer, attach the other side of the absorbent resin layer to the center of the high water permeability medical pressure-sensitive adhesive layer, and then re-cover the release layer on top of the high water permeability medical pressure-sensitive adhesive layer and the absorbent resin layer.

[0020] Compared with the prior art, the beneficial effects of the present invention are:

[0021] 1. The absorbent resin layer of the present invention can absorb wound exudate in a timely manner, keeping the wound dry. Furthermore, the absorbent resin layer binds chitosan quaternary ammonium salt with a water-soluble adhesive. During the absorption of wound exudate, the chitosan quaternary ammonium salt dissolves, and the cations in the chitosan quaternary ammonium salt interact with the anions on the surface of microbial cells, inducing local cell wall changes, leakage of internal enzymes, and plasmolysis, thereby killing bacteria and promoting wound healing.

[0022] 2. This invention utilizes a triple transparent structure consisting of a backing layer, a highly water-permeable medical pressure-sensitive adhesive layer, and a water-absorbing resin layer to achieve full-process visual monitoring of wound healing. Medical staff can observe the wound condition without frequently removing the dressing, effectively avoiding secondary damage and infection risks caused by repeated dressing removal. Compared to traditional opaque dressings, this invention significantly improves the convenience and safety of clinical care.

[0023] 3. The area of ​​the water-absorbing resin layer is smaller than that of the high water-permeable medical pressure-sensitive adhesive layer. The water-absorbing resin layer is located in the center of the high water-permeable medical pressure-sensitive adhesive layer. The water-based resin layer contacts the wound and is not adhesive. The high water-permeable medical pressure-sensitive adhesive layer around the water-based resin layer is used to adhere to the skin, which helps the water-based resin layer adhere to the wound and avoids contact between the adhesive substrate and the wound.

[0024] 4. Both the backing layer and the high-water-permeable medical pressure-sensitive adhesive layer have high moisture permeability, reducing the overall stuffy feeling of the dressing and providing patients with a better user experience. Attached Figure Description

[0025] Figure 1 This is a schematic diagram of the structure of the transparent and visual antibacterial wound dressing of the present invention;

[0026] The implementation, functional features, and advantages of this invention will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0027] The following examples further illustrate the features and other related characteristics of the present invention in detail, to facilitate understanding by those skilled in the art:

[0028] like Figure 1 As shown, this invention provides a transparent and visible antibacterial wound dressing, comprising a backing layer 1, a high water-permeable medical pressure-sensitive adhesive layer 2, a water-absorbing resin layer 3, and a release layer 4 stacked longitudinally. The backing layer 1, the high water-permeable medical pressure-sensitive adhesive layer 2, and the release layer 4 all have the same area. The water-absorbing resin layer 3 is located at the center of the high water-permeable medical pressure-sensitive adhesive layer 2, and its area is smaller than that of the high water-permeable medical pressure-sensitive adhesive layer 2. The backing layer 1, the high water-permeable medical pressure-sensitive adhesive layer 2, and the water-absorbing resin layer 3 are all transparent. The side of the water-absorbing resin layer 3 facing the release layer 4 is bonded with chitosan quaternary ammonium salt 5 by a water-soluble adhesive.

[0029] In some embodiments, the water-soluble adhesive is a water-soluble starch adhesive, which has good biocompatibility and does not cause wound irritation.

[0030] In some embodiments, the thickness of the absorbent resin layer is 10 to 100 μm, which is thin and can fit the wound. The absorbent resin layer has a water absorption volume of not less than 20 times its own volume.

[0031] In some embodiments, the amount of chitosan quaternary ammonium salt added is 5–50 g / m³. 2 This ensures the antibacterial effect on the lower surface of the absorbent resin layer.

[0032] In some embodiments, the thickness of the high water permeability medical pressure-sensitive adhesive layer is 20-40 μm, which can ensure a firm connection between the water-absorbing resin layer and the backing layer.

[0033] In some embodiments, the high water permeability medical pressure-sensitive adhesive layer can be a water-based polyacrylate pressure-sensitive adhesive or a water-based polyurethane pressure-sensitive adhesive.

[0034] In some embodiments, the backing layer is a polyurethane film layer, which has good breathability, optical transparency, and can withstand high water pressure, making the dressing surface waterproof.

[0035] In some embodiments, the polyurethane film layer has a thickness of 10–50 μm and provides mechanical support as a dressing substrate.

[0036] In some embodiments, the water vapor permeability of both the high water-permeable medical pressure-sensitive adhesive layer and the polyurethane film layer is greater than 3000 g / m² within 24 hours. 2 Water vapor between the skin and the polyurethane film layer can be expelled in time, preventing the accumulation of sweat and thus avoiding adverse allergic reactions such as itching and eczema.

[0037] In some embodiments, the release layer has a basis weight of 80–150 g / m². 2 Single-sided coated release paper or release film with a thickness of 50-100μm.

[0038] This invention provides a method for preparing a transparent and visible antibacterial wound dressing, comprising the following steps:

[0039] Step 1: Coat the release layer with high water permeability medical pressure-sensitive adhesive, and dry to form a high water permeability medical pressure-sensitive adhesive layer;

[0040] Step 2: Press the backing layer onto the high water permeability medical pressure-sensitive adhesive layer;

[0041] Step 3: Coat one side of the absorbent resin layer with a starch adhesive solution, and before the starch adhesive solution dries, evenly sprinkle chitosan quaternary ammonium salt powder onto the absorbent resin layer. After drying, the chitosan quaternary ammonium salt adheres to the absorbent resin layer.

[0042] Step 4: Tear off the release layer, attach the other side of the absorbent resin layer to the center of the high water permeability medical pressure-sensitive adhesive layer, and then re-cover the high water permeability medical pressure-sensitive adhesive layer and the absorbent resin layer with the release layer.

[0043] In some embodiments, in step two, the polyurethane film is aligned with the high water permeability medical pressure-sensitive adhesive layer, and then pressed together by a composite pressure roller.

[0044] Example 1

[0045] A dressing is prepared by the following steps:

[0046] Step 1: Select an A4-sized sheet of 100g / m 2 The single-sided coated release paper is coated with water-based medical pressure-sensitive adhesive and then placed in a 100℃ oven for drying. After drying, a high water-permeable medical pressure-sensitive adhesive layer with a thickness of 25μm is formed.

[0047] Step 2: Select a thickness of 30μm, with a water vapor permeability of 4000g / m² over 24 hours. 2 The polyurethane film is cut into A4 size. Then, the polyurethane film is aligned with the high water-permeable medical pressure-sensitive adhesive layer, bonded together, and then pressed into one piece by a composite pressure roller to make a polyurethane film adhesive patch.

[0048] Step 3: Select a sodium polyacrylate membrane with a diameter of 3 cm × 3 cm × 20 μm. The water absorption volume of the sodium polyacrylate membrane is 28 times its own volume. Coat one side of the sodium polyacrylate membrane with a starch adhesive solution. Before the starch adhesive solution dries, evenly sprinkle chitosan quaternary ammonium salt powder onto the water-absorbing resin layer. Dry the membrane. The amount of chitosan quaternary ammonium salt added is 10 g / m². 2 .

[0049] Step 4: Peel off the release paper of the polyurethane film adhesive and attach the sodium polyacrylate film to the center of the polyurethane film. Then, re-cover the release layer on top of the high water-permeable medical pressure-sensitive adhesive layer and the water-absorbing resin layer. Next, trim off the excess polyurethane film tape at the edges, ensuring the sodium polyacrylate film is centered. Cut the entire dressing to a 7cm x 7cm size to create a wound dressing sample.

[0050] Example 2

[0051] Example 2 provides a dressing in which the amount of chitosan quaternary ammonium salt added is 40 g / m 2 Its preparation method is the same as that in Example 1.

[0052] Comparative Example 1

[0053] Comparative Example 1 provides a dressing without the addition of chitosan quaternary ammonium salt, and its preparation method is the same as that of Example 1.

[0054] Performance testing

[0055] Staphylococcus aureus commonly resides on human skin and in wounds. Using an inoculation loop, gently scrape a loopful of Staphylococcus aureus colonies and inoculate it into 100 mL of nutrient broth. Incubate at 37°C on a shaker at 150 rpm for 24 hours. Dilute the bacterial suspension to 3.0 × 10⁻⁶ with physiological saline. 6 CFU / ml, for antibacterial testing.

[0056] Take dressing samples from Examples 1-2 and Comparative Example 1, peel off the release layer, and then take 10 ml of the above bacterial suspension from each sample and drop it onto the sodium polyacrylate sheet in the middle of the three wound dressing samples, and let it stand at 37°C for 2 hours.

[0057] Next, the dressing sample was cut into small pieces, 100 ml was placed in physiological saline, and then incubated in a constant temperature shaker at 37°C and 150 r / min for 24 h.

[0058] Finally, take 1 ml of the solution for viable cell count, place it on a regular nutrient agar plate and spread it evenly, observe the bacterial growth of each sample, count the average colony count (CFU), and calculate the sterilization rate R = 100% * (AB) / A. A is the average colony count of Comparative Example 1, and B is the average colony count of Examples 1-2 and Comparative Example 1.

[0059] Table 1 compares the sterilization rates of Examples 1-2 and Comparative Example 1.

[0060] sample Example 1 Example 2 Comparative Example Sterilization rate R (%) 91 97 0

[0061] As shown in Table 1, under the initial condition of a large number of live Staphylococcus aureus, the bactericidal rate of Example 1 was 91%, the bactericidal rate of Example 2 was 97%, while the bactericidal rate of Comparative Example 1 was 0% due to the lack of chitosan quaternary ammonium salt. This indicates that introducing chitosan quaternary ammonium salt into the dressing can provide a good antibacterial effect, and the higher the amount of chitosan quaternary ammonium salt added, the better its antibacterial effect.

[0062] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made based on the description and drawings of the present invention, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of the present invention.

Claims

1. A transparent, visually-oriented antibacterial wound dressing, characterized in that, The device comprises a backing layer (1), a high water-permeable medical pressure-sensitive adhesive layer (2), a water-absorbing resin layer (3), and a release layer (4) stacked longitudinally. The backing layer (1), the high water-permeable medical pressure-sensitive adhesive layer (2), and the release layer (4) have the same area, while the area of ​​the water-absorbing resin layer (3) is smaller than that of the high water-permeable medical pressure-sensitive adhesive layer (2). All three layers are transparent. The side of the water-absorbing resin layer (3) facing the release layer (4) is bonded with chitosan quaternary ammonium salt (5) using a water-soluble adhesive. The water-soluble adhesive is a water-soluble starch adhesive. The thickness of the high water-permeable medical pressure-sensitive adhesive layer (2) is 20-40 μm, and its water vapor permeability is greater than 3000 g / m² within 24 hours. 2 The amount of chitosan quaternary ammonium salt added is 5~50 g / m³. 2 .

2. The transparent and visual antibacterial wound dressing according to claim 1, characterized in that, The thickness of the water-absorbing resin layer (3) is 10~100μm, and the water absorption volume of the water-absorbing resin layer (3) is not less than 20 times its own volume.

3. The transparent and visual antibacterial wound dressing according to claim 2, characterized in that, The absorbent resin layer (3) is a sodium polyacrylate resin layer.

4. The transparent and visual antibacterial wound dressing according to claim 1, characterized in that, The backing layer (1) is a polyurethane film layer.

5. The transparent and visual antibacterial wound dressing according to claim 4, characterized in that, The thickness of the polyurethane film layer is 10~50μm, and the water vapor permeability of the backing layer (1) is greater than 3000g / m² within 24 hours. 2 .

6. The transparent and visual antibacterial wound dressing according to claim 1, characterized in that, The water-absorbing resin layer is located at the center of the high water-permeable medical pressure-sensitive adhesive layer.

7. A method for preparing a transparent, visual, antibacterial wound dressing as described in any one of claims 1 to 6, characterized in that, Includes the following steps: Step 1: Coat the release layer (4) with high water permeability medical pressure-sensitive adhesive and dry it to form a high water permeability medical pressure-sensitive adhesive layer (2). Step 2: Press the backing layer (1) onto the high water permeability medical pressure-sensitive adhesive layer (2); Step 3: Apply starch glue solution to one side of the water-absorbing resin layer (3), and before the starch glue solution dries, evenly sprinkle chitosan quaternary ammonium salt powder on the water-absorbing resin layer (3), dry, and the chitosan quaternary ammonium salt adheres to the water-absorbing resin layer (3). Step 4: Tear off the release layer (4), attach the other side of the absorbent resin layer (3) to the center of the high water permeability medical pressure-sensitive adhesive layer (2), and then re-cover the release layer (4) on the high water permeability medical pressure-sensitive adhesive layer (2) and the absorbent resin layer (3).

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