Preparation method of giant salamander peptide eucommia male flower tablets

Abstract

The invention relates to the technical field of preparation methods of giant salamander peptide and eucommia ulmoides male flower tablets, in particular to a preparation method of giant salamander peptide and eucommia ulmoides male flower tablets. The giant salamander peptide and eucommia ulmoides male flower tablets comprise the following raw materials in parts by weight: 30-40 parts of giant salamander peptide powder, 20-25 parts of eucommia ulmoides male flowers, 10-15 parts of rape pollen, 10-15 parts of sea cucumber intestine peptide powder, 10-12 parts of a filler, 3-5 parts of an adhesive and 1-3 parts of a lubricant. According to the invention, the eucommia male flower contains geniposidic acid, chlorogenic acid, aucubin lignin, iridoid and phenylpropanoid natural active nutrient substances, flavonoid compounds, polysaccharide and other bioactive substances in the rape pollen, polysaccharide and peptide components in the sea cucumber intestine peptide powder, and the like. The andrias davidianus peptide powder is added into the andrias davidianus peptide powder, the andrias davidianus peptide powder cooperates with antioxidant peptide and immunomodulatory peptide in the andrias davidianus peptide powder to jointly form a rich bioactive substance library, and the components regulate the physiological functions of the human body from different angles, provide comprehensive nutrition support for the body and improve the fatigue resistance of the human body.

Description

Technical Field

[0001] The invention relates to the technical field of preparation methods of giant salamander peptide eucommia male flower slices, in particular to a preparation method of giant salamander peptide eucommia male flower slices. Background Art

[0002] Giant salamander, commonly known as baby fish, is an animal with high nutritional value. Its muscles are rich in protein, amino acids and trace elements. The glands of giant salamanders are also rich in peptides. The Eucommia tree is dioecious, and the flowers of the male tree are called Eucommia male flowers. Its flowering period is short and the resources are extremely scarce. Eucommia male flowers are rich in lignin, cyclopentane ether terpenes, and phenylpropanoid natural active nutrients, such as geniposide, chlorogenic acid, and aucubin. It also contains pinoresinol disaccharide glycosides, flavonoids, alkaloids, polysaccharides and mineral elements. Among them, the amino acid content reaches 21.47%, and the active ingredients are the most comprehensive and the content is higher.

[0003] Most existing health products have single ingredients and cannot meet people's needs for comprehensive health care. As for raw materials such as giant salamander peptide and Eucommia ulmoides male flowers, although they each have rich nutritional value and health benefits, the effect of using them alone is limited, and in the preparation process, the extraction efficiency of the effective ingredients of Eucommia ulmoides male flowers needs to be improved.

[0004] Based on this, the present invention provides a method for preparing giant salamander peptide ulmoides male flower slices. Summary of the Invention

[0005] The purpose of the present invention is to provide a preparation method of giant salamander peptide eucommia male flower slices. The giant salamander peptide eucommia male flower slices prepared by the present invention have good anti-fatigue properties, improve grip strength and nerve response, and effectively improve the performance of giant salamander peptide eucommia male flower slices.

[0006] To achieve the above object, the present invention provides the following technical solution: a giant salamander peptide and eucommia male flower tablet, comprising the following raw materials in parts by weight: 30-40 parts of giant salamander peptide powder, 20-25 parts of eucommia male flowers, 10-15 parts of rapeseed pollen, 10-15 parts of sea cucumber intestinal peptide powder, 10-12 parts of filler, 3-5 parts of adhesive and 1-3 parts of lubricant;

[0007] The giant salamander peptide powder and sea cucumber intestinal peptide powder are pretreated;

[0008] The rapeseed flowers are micronized;

[0009] The male flowers of Eucommia ulmoides are subjected to enzymatic hydrolysis and drying treatment.

[0010] Preferably, the sea cucumber intestinal peptide pretreatment step is: spreading high-quality sea cucumber intestinal peptide powder on a tray, placing it in a processing chamber of a plasma treatment device, setting the pressure to 50-100 Pa, and introducing nitrogen at a speed of 10-100 sccm, treating for 10-30 minutes to complete the pretreatment of the sea cucumber intestinal peptide powder.

[0011] Preferably, the pretreatment step of the giant salamander peptide powder is: selecting high-quality giant salamander peptide powder and sieving it through a 100-200 mesh sieve, and adding the sieved giant salamander peptide powder to a vacuum dryer, setting the temperature to 40-60°C, the vacuum degree to -0.08 to -0.1 MPa, and continuing drying for 2-4 hours.

[0012] Preferably, the rapeseed pollen micronization treatment step is: after passing the rapeseed pollen through an 80-mesh sieve, it is dried in a vacuum dryer at -20°C to a moisture content of less than or equal to 5%, the dried rapeseed pollen and liquid nitrogen are placed in a low-temperature constant temperature reaction bath and mixed and pre-cooled to -40°C for 10 minutes, the pre-cooled rapeseed pollen is put into an ultrafine grinder, and crushed at -40 to -45°C for 30 minutes, and taken out and sieved through an 800-mesh sieve to complete the rapeseed pollen micronization treatment.

[0013] Preferably, the enzymatic hydrolysis and drying treatment step of the male flowers of Eucommia ulmoides is as follows: the male flowers of Eucommia ulmoides are crushed by a hammer mill and sieved through an 80-mesh screen to obtain male pollen of Eucommia ulmoides, water, male pollen of Eucommia ulmoides, protease, cellulase and pectinase are added to a constant temperature water bath, and stirred with a stirrer, set at 180-400 r / min for 10-30 minutes, and after enzymatic hydrolysis at 45-50°C for 4 hours, the enzymatic hydrolyzate is taken out and placed in a multifunctional extraction tank, and pure water is added, and the treatment is continued at 90-95°C. 2.5h, during the treatment process, anchor stirring is used to continuously stir at 20-40rpm to complete the micro-boiling extraction, and the extract is taken out and placed in a centrifugal filter for solid-liquid separation. After 15-30min at 4000-5000r / min, the filtrate is collected and the supernatant is taken, and the supernatant is added to a spray dryer, and the inlet air temperature is set to 120-180°C, the outlet air temperature is set to 60-90°C, and the feed rate is 5-20ml / min to obtain the eucommia male flower powder, thereby completing the enzymatic hydrolysis and drying treatment of the eucommia male flower.

[0014] Preferably, the mass ratio of the water, Eucommia ulmoides male pollen, protease, cellulase and pectinase is (5-8):1:0.05:0.03:0.02, and the mass ratio of the enzymatic hydrolyzate to pure water is 6:4.

[0015] Preferably, the filler is starch or lactose.

[0016] Preferably, the binder is hydroxypropyl methylcellulose or povidone.

[0017] Preferably, the lubricant is magnesium stearate or talc.

[0018] A method for preparing giant salamander peptide eucommia male flower tablets comprises the following steps:

[0019] Step 1: Weigh the pretreated giant salamander peptide powder and sea cucumber intestinal peptide powder, micronized rapeseed pollen, enzymatically dried eucommia male flower powder, filler, lubricant and adhesive as needed, and put them into a three-dimensional motion mixture, and stir at 20-30 r / min for 30 minutes to obtain a mixed powder;

[0020] Step 2: Add the mixed powder and pure water into a mixer, wherein the mass ratio of the mixed powder to pure water is 1:(0.2-0.4), stir at 400-500 r / min for 10-15 minutes to obtain a soft material, and granulate through a 16-20 mesh sieve;

[0021] Step 3: Place the granules in a rotary tablet press, set the speed to 20-40 rpm and the pressure to 10-20 KN, and place them in a fluidized bed coater for coating to complete the preparation of giant salamander peptide Eucommia male flower tablets.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] 1. In the present invention, the male flowers of Eucommia ulmoides contain natural active nutrients such as geniposide, chlorogenic acid, aucubin lignin, iridoids, and phenylpropanoids; the flavonoids and polysaccharides in rapeseed pollen are bioactive substances; the polysaccharides and peptide components in sea cucumber intestinal peptide powder work together with the antioxidant peptides and immunomodulatory peptides in giant salamander peptide powder to form a rich library of bioactive substances. These components regulate the physiological functions of the human body from different angles, provide the body with all-round nutritional support, and enhance the body's anti-fatigue ability.

[0024] 2. In the present invention, giant salamander peptide, eucommia male flower, rapeseed pollen and sea cucumber intestinal peptide powder all have certain antioxidant capacity. The antioxidant components they contain, such as superoxide dismutase, polyphenols and flavonoids, can synergistically eliminate free radicals in the body and reduce the damage of oxidative stress to the body. At the same time, these components can also promote energy metabolism, accelerate the decomposition and discharge of fatigue substances, improve muscle endurance and the body's anti-fatigue ability, and enable people to recover their physical strength faster after exercise or work.

[0025] 3. The present invention performs enzymatic hydrolysis and drying treatment on the male flowers of Eucommia ulmoides. During the process, cellulase can decompose cellulose, pectinase can degrade pectin, etc., destroying the structure of the cell wall, making it easier to expose and release the effective ingredients in the cell. At the same time, under the action of protease, cellulase and pectinase, they can specifically recognize and act on the corresponding substrates, accelerate the decomposition of cell wall components and some substances in the cell that are bound to the effective ingredients, reduce the resistance of the effective ingredients to diffuse from the cell to the outside of the cell, and thus promote the precipitation of the effective ingredients. DETAILED DESCRIPTION

[0026] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0027] It should be noted that the raw materials used in the following experiments are all commercially available raw materials.

[0028] Example 1:

[0029] A giant salamander peptide and eucommia male flower tablet comprising the following raw materials in parts by weight: 30 parts of giant salamander peptide powder, 20 parts of eucommia male flowers, 10 parts of rapeseed pollen, 10 parts of sea cucumber intestinal peptide powder, 10 parts of filler, 3 parts of adhesive and 1 part of lubricant;

[0030] Giant salamander peptide powder and sea cucumber intestinal peptide powder were pretreated;

[0031] Rapeseed flowers are micronized;

[0032] The male flowers of Eucommia ulmoides are subjected to enzymatic hydrolysis and drying treatment.

[0033] The pretreatment steps of sea cucumber intestinal peptide are as follows: spread high-quality sea cucumber intestinal peptide powder on a tray, place it in the processing chamber of the plasma treatment equipment, set the pressure to 50pa, and introduce nitrogen at a speed of 10sccm for 10 minutes to complete the pretreatment of the sea cucumber intestinal peptide powder.

[0034] The pretreatment steps of giant salamander peptide powder are as follows: select high-quality giant salamander peptide powder and sieve it with a 100-mesh sieve, and add the sieved giant salamander peptide powder to a vacuum dryer, set the temperature to 40°C, the vacuum degree to -0.08MPa, and continue drying for 2 hours.

[0035] The rapeseed pollen micronization process comprises the following steps: passing the rapeseed pollen through an 80-mesh sieve, drying the rapeseed pollen in a vacuum dryer at -20°C to a moisture content of less than or equal to 5%, mixing the dried rapeseed pollen with liquid nitrogen in a low-temperature constant-temperature reaction bath and precooling the mixture to -40°C for 10 minutes, placing the precooled rapeseed pollen in an ultrafine grinder, crushing the pollen at -40°C for 30 minutes, taking the pollen out and sieving it through an 800-mesh sieve, and completing the rapeseed pollen micronization process.

[0036] The enzymatic hydrolysis and drying treatment steps of the male flowers of Eucommia ulmoides are as follows: the male flowers of Eucommia ulmoides are crushed by a hammer mill and sieved through an 80-mesh sieve to obtain male pollen of Eucommia ulmoides, water, male pollen of Eucommia ulmoides, protease, cellulase and pectinase are added to a constant temperature water bath, and stirred with a stirrer, set at 180 r / min for 10 minutes, and after enzymatic hydrolysis at 45°C for 4 hours, the enzymatic hydrolyzate is taken out and placed in a multifunctional extraction tank, and pure water is added, and the treatment is continued at 90°C for 2.5 hours. During the treatment process, anchor stirring is used to continuously stir at 20 rpm to complete micro-boiling extraction, and the flowers are taken out and placed in a centrifugal filter for solid-liquid separation. After being continuously stirred at 4000 r / min for 15 minutes, the filtrate is collected and the supernatant is taken, and the supernatant is added to a spray dryer, the inlet air temperature is set at 120°C, the outlet air temperature is set at 60°C, and the feed rate is 5 ml / min to obtain the male flower powder of Eucommia ulmoides, thereby completing the enzymatic hydrolysis and drying treatment of the male flowers of Eucommia ulmoides.

[0037] The mass ratio of water, Eucommia ulmoides male pollen, protease, cellulase and pectinase is 5:1:0.05:0.03:0.02, and the mass ratio of enzymatic hydrolysate to pure water is 6:4.

[0038] The filler is starch.

[0039] The binder is hydroxypropyl methylcellulose.

[0040] The lubricant used is magnesium stearate.

[0041] A method for preparing giant salamander peptide eucommia male flower tablets comprises the following steps:

[0042] Step 1: Weigh the pretreated giant salamander peptide powder and sea cucumber intestinal peptide powder, micronized rapeseed pollen, enzymatically dried eucommia male flower powder, filler, lubricant and adhesive as needed, and put them into a three-dimensional motion mixture, and stir at 20-30 r / min for 30 minutes to obtain a mixed powder;

[0043] Step 2: Add the mixed powder and pure water into a mixer with a mass ratio of 1:0.2, stir at 400 r / min for 10 min to obtain a soft material, and granulate through a 16-mesh sieve;

[0044] Step 3: Place the granules in a rotary tablet press, set the speed to 20 rpm and the pressure to 10 KN, and place them in a fluidized bed coater for coating treatment to complete the preparation of giant salamander peptide Eucommia male flower tablets.

[0045] Example 2:

[0046] A giant salamander peptide and eucommia male flower tablet comprising the following raw materials in parts by weight: 35 parts of giant salamander peptide powder, 22 parts of eucommia male flowers, 12 parts of rapeseed pollen, 12 parts of sea cucumber intestinal peptide powder, 11 parts of filler, 4 parts of adhesive and 2 parts of lubricant;

[0047] Giant salamander peptide powder and sea cucumber intestinal peptide powder were pretreated;

[0048] Rapeseed flowers are micronized;

[0049] The male flowers of Eucommia ulmoides are subjected to enzymatic hydrolysis and drying treatment.

[0050] The pretreatment steps of sea cucumber intestinal peptide are as follows: spread high-quality sea cucumber intestinal peptide powder on a tray, place it in the processing chamber of the plasma treatment equipment, set the pressure to 75pa, and introduce nitrogen at a speed of 50sccm for 20 minutes to complete the pretreatment of the sea cucumber intestinal peptide powder.

[0051] The pretreatment steps of giant salamander peptide powder are as follows: select high-quality giant salamander peptide powder and sieve it with a 150-mesh sieve, and add the sieved giant salamander peptide powder to a vacuum dryer, set the temperature to 50°C, the vacuum degree to -0.09MPa, and continue drying for 3 hours.

[0052] The rapeseed pollen micronization process comprises the following steps: passing the rapeseed pollen through an 80-mesh sieve, drying the rapeseed pollen in a vacuum dryer at -20°C to a moisture content of less than or equal to 5%, mixing the dried rapeseed pollen with liquid nitrogen in a low-temperature constant-temperature reaction bath and precooling the mixture to -40°C for 10 minutes, placing the precooled rapeseed pollen in an ultrafine grinder, crushing the pollen at -42°C for 30 minutes, taking the pollen out and sieving it through an 800-mesh sieve, and completing the rapeseed pollen micronization process.

[0053] The enzymatic hydrolysis and drying treatment steps of the male flowers of Eucommia ulmoides are as follows: the male flowers of Eucommia ulmoides are crushed by a hammer mill and sieved through an 80-mesh sieve to obtain male pollen of Eucommia ulmoides, water, male pollen of Eucommia ulmoides, protease, cellulase and pectinase are added to a constant temperature water bath, and stirred with a stirrer, set at 300 r / min for 20 minutes, and after enzymatic hydrolysis at 47°C for 4 hours, the enzymatic hydrolyzate is taken out and placed in a multifunctional extraction tank, and pure water is added, and the treatment is continued at 92°C for 2.5 hours. During the treatment process, anchor stirring is used to continuously stir at 30 rpm to complete micro-boiling extraction, and the extract is taken out and placed in a centrifugal filter for solid-liquid separation. After continuing at 4500 r / min for 22 minutes, the filtrate is collected and the supernatant is taken, and the supernatant is added to a spray dryer, the inlet air temperature is set at 160°C, the outlet air temperature is set at 75°C, and the feed rate is 12 ml / min to obtain the male flower powder of Eucommia ulmoides, thereby completing the enzymatic hydrolysis and drying treatment of the male flowers of Eucommia ulmoides.

[0054] The mass ratio of water, Eucommia ulmoides male pollen, protease, cellulase and pectinase is 6.5:1:0.05:0.03:0.02, and the mass ratio of enzymatic hydrolysate to pure water is 6:4.

[0055] The filler is lactose.

[0056] The adhesive is povidone.

[0057] The lubricant is talcum powder.

[0058] A method for preparing giant salamander peptide eucommia male flower tablets comprises the following steps:

[0059] Step 1: Weigh the pretreated giant salamander peptide powder and sea cucumber intestinal peptide powder, micronized rapeseed pollen, enzymatically dried eucommia male flower powder, filler, lubricant and adhesive as needed, and put them into a three-dimensional motion mixture, and stir at 20-30 r / min for 30 minutes to obtain a mixed powder;

[0060] Step 2: Add the mixed powder and pure water into a mixer with a mass ratio of 1:0.3, stir at 450 r / min for 12 min to obtain a soft material, and granulate through an 18-mesh sieve;

[0061] Step 3: Place the granules in a rotary tablet press, set the speed to 30 rpm and the pressure to 15 KN, and place them in a fluidized bed coater for coating treatment to complete the preparation of giant salamander peptide Eucommia male flower tablets.

[0062] Example 3:

[0063] A giant salamander peptide and eucommia male flower tablet comprising the following raw materials in parts by weight: 40 parts of giant salamander peptide powder, 25 parts of eucommia male flowers, 15 parts of rapeseed pollen, 15 parts of sea cucumber intestinal peptide powder, 12 parts of filler, 5 parts of adhesive and 3 parts of lubricant;

[0064] Giant salamander peptide powder and sea cucumber intestinal peptide powder were pretreated;

[0065] Rapeseed flowers are micronized;

[0066] The male flowers of Eucommia ulmoides are subjected to enzymatic hydrolysis and drying treatment.

[0067] The pretreatment steps of sea cucumber intestinal peptide are as follows: spread high-quality sea cucumber intestinal peptide powder on a tray, place it in the processing chamber of the plasma treatment equipment, set the pressure to 100pa, and introduce nitrogen at a speed of 100sccm for 30 minutes to complete the pretreatment of the sea cucumber intestinal peptide powder.

[0068] The pretreatment steps of giant salamander peptide powder are as follows: select high-quality giant salamander peptide powder and sieve it with a 200-mesh sieve, and add the sieved giant salamander peptide powder to a vacuum dryer, set the temperature to 60°C, the vacuum degree to -0.1MPa, and continue drying for 4 hours.

[0069] The rapeseed pollen micronization process comprises the following steps: passing the rapeseed pollen through an 80-mesh sieve, drying the rapeseed pollen in a vacuum dryer at -20°C to a moisture content of less than or equal to 5%, mixing the dried rapeseed pollen with liquid nitrogen in a low-temperature constant-temperature reaction bath and precooling the mixture to -40°C for 10 minutes, placing the precooled rapeseed pollen in an ultrafine grinder, and crushing the mixture at -45°C for 30 minutes, taking the rapeseed pollen out and sieving it through an 800-mesh sieve, thereby completing the rapeseed pollen micronization process.

[0070] The enzymatic hydrolysis and drying treatment steps of the eucommia male flower are as follows: the eucommia male flower is crushed by a hammer mill and sieved through an 80-mesh sieve to obtain eucommia male pollen, water, eucommia male pollen, protease, cellulase and pectinase are added to a constant temperature water bath, and stirred with a stirrer, set at 400 r / min for 30 minutes, and after enzymatic hydrolysis at 50°C for 4 hours, the enzymatic hydrolyzate is taken out and placed in a multi-functional extraction tank, and pure water is added, and the treatment is continued at 95°C for 2.5 hours. During the treatment process, anchor stirring is used to continuously stir at 40 rpm to complete micro-boiling extraction, and the eucommia male flower is taken out and placed in a centrifugal filter for solid-liquid separation. After continuing at 5000 r / min for 30 minutes, the filtrate is collected and the supernatant is taken, and the supernatant is added to a spray dryer, the inlet air temperature is set at 180°C, the outlet air temperature is set at 90°C, and the feed rate is 20 ml / min to obtain eucommia male flower powder, thereby completing the enzymatic hydrolysis and drying treatment of the eucommia male flower.

[0071] The mass ratio of water, Eucommia ulmoides male pollen, protease, cellulase and pectinase is 8:1:0.05:0.03:0.02, and the mass ratio of enzymatic hydrolysate to pure water is 6:4.

[0072] The filler is lactose.

[0073] The binder is hydroxypropyl methylcellulose.

[0074] The lubricant used is magnesium stearate.

[0075] A method for preparing giant salamander peptide eucommia male flower tablets comprises the following steps:

[0076] Step 1: weighing pretreated giant salamander peptide powder and sea cucumber intestinal peptide powder, micronized rapeseed pollen, enzymatically dried eucommia male flower powder, filler, lubricant and adhesive as needed, and putting them into a three-dimensional motion mixture, stirring at 30 r / min for 30 minutes to obtain a mixed powder;

[0077] Step 2: Add the mixed powder and pure water into a mixer with a mass ratio of 1:0.4, stir at 500 r / min for 15 minutes to obtain a soft material, and granulate through a 20-mesh sieve;

[0078] Step 3: Place the granules in a rotary tablet press, set the speed to 40 rpm and the pressure to 20 KN, and place them in a fluidized bed coater for coating treatment to complete the preparation of giant salamander peptide Eucommia male flower tablets.

[0079] Comparative Example 1: The difference between this comparative example and Experiment 1 is that the male flowers of Eucommia ulmoides were not subjected to enzymatic hydrolysis and drying treatment in this comparative example.

[0080] Comparative Example 2: The difference between this comparative example and Experiment 1 is that no sea cucumber intestinal peptide powder is added in this comparative example.

[0081] Comparative Example 3: This comparative example is different from Experiment 1 in that no eucommia male flowers are added in this comparative example.

[0082] Comparative Example 4: The difference between this comparative example and Experiment 1 is that the rapeseed pollen was not micronized in this comparative example.

[0083] Performance test: The performance test was conducted on the giant salamander peptide Eucommia ulmoides male flower slices prepared in Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, Comparative Example 3 and Comparative Example 4.

[0084] Test items include fatigue resistance test, grip strength test and reaction test;

[0085] Among them, the fatigue resistance test, grip strength test, and reaction time test recruited 30 healthy middle-aged men for the test, who took giant salamander peptide Eucommia ulmoides male flower tablets daily for 8 weeks. The control group consisted of 15 people. The fatigue resistance test was conducted by testing the endurance on a treadmill, the grip strength test was conducted by using a handgrip strength machine, and the reaction test was conducted by the subjects pressing buttons to respond to the green light spots that appeared randomly on the screen, and the average reaction time was recorded.

[0086] The obtained test data are recorded in the following table:

[0087]

[0088] By comparing and analyzing the relevant data in the table, it can be seen that the preparation method of the present invention for the preparation of the giant salamander peptide Eucommia male flower slices not only has good anti-fatigue properties, but also improves grip strength and nerve response. This shows that the preparation method of the giant salamander peptide Eucommia male flower slices provided by the present invention has a broader market prospect and is more suitable for promotion.

[0089] Throughout this specification, references to terms such as "one embodiment," "example," and "specific example" indicate that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of these terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0090] The preferred embodiments of the present invention disclosed above are intended only to help illustrate the present invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the present invention to the specific embodiments described. Obviously, many modifications and variations are possible based on the content of this specification. These embodiments are selected and described in detail in this specification to better explain the principles and practical applications of the present invention, thereby enabling those skilled in the art to better understand and utilize the present invention. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A giant salamander peptide Eucommia ulmoides male flower tablet, characterized by: The method comprises the following raw materials in parts by weight: 30-40 parts of giant salamander peptide powder, 20-25 parts of eucommia male flowers, 10-15 parts of rapeseed flower pollen, 10-15 parts of sea cucumber intestinal peptide powder, 10-12 parts of filler, 3-5 parts of adhesive and 1-3 parts of lubricant; The giant salamander peptide powder and sea cucumber intestinal peptide powder are pretreated; The rapeseed flowers are micronized; The male flowers of Eucommia ulmoides are subjected to enzymatic hydrolysis and drying treatment.

2. The Eucommia ulmoides male flower slice according to claim 1, characterized in that: The sea cucumber intestinal peptide pretreatment steps are: spreading high-quality sea cucumber intestinal peptide powder on a tray, placing it in a processing chamber of a plasma treatment device, setting the pressure to 50-100 Pa, and introducing nitrogen at a speed of 10-100 sccm, treating for 10-30 minutes to complete the pretreatment of the sea cucumber intestinal peptide powder.

3. The Eucommia ulmoides male flower slice according to claim 1, characterized in that: The pretreatment step of the giant salamander peptide powder is as follows: selecting high-quality giant salamander peptide powder and sieving it through a 100-200 mesh sieve, and adding the sieved giant salamander peptide powder into a vacuum dryer, setting the temperature to 40-60° C., the vacuum degree to -0.08 to -0.1 MPa, and continuing drying for 2-4 hours.

4. The Eucommia ulmoides male flower slice according to claim 1, characterized in that: The rapeseed flower micronization treatment steps include: passing the rapeseed pollen through an 80-mesh sieve, drying it in a vacuum dryer at -20°C until the moisture content is less than or equal to 5%, placing the dried rapeseed pollen and liquid nitrogen in a low-temperature constant-temperature reaction bath, mixing and precooling to -40°C for 10 minutes, adding the precooled rapeseed pollen into an ultrafine grinder, crushing it at -40 to -45°C for 30 minutes, taking it out and sieving it through an 800-mesh sieve, thereby completing the rapeseed pollen micronization treatment.

5. The Eucommia ulmoides male flower slice according to claim 1, characterized in that: The enzymatic hydrolysis and drying treatment of the male flowers of Eucommia ulmoides comprises the following steps: crushing the male flowers of Eucommia ulmoides with a hammer mill and sieving them through an 80-mesh screen to obtain male pollen of Eucommia ulmoides; adding water, male pollen of Eucommia ulmoides, protease, cellulase and pectinase into a constant temperature water bath; stirring with a stirrer at 180-400 r / min for 10-30 minutes; performing enzymatic hydrolysis at 45-50° C. for 4 hours; taking out the enzymatic hydrolyzate and placing it in a multifunctional extraction tank; adding pure water; and continuously treating at 90-95° C. for 2 hours. 5h, during the treatment process, anchor stirring is used to continuously stir at 20-40rpm to complete the micro-boiling extraction, and the extract is taken out and placed in a centrifugal filter for solid-liquid separation. After 15-30min at 4000-5000r / min, the filtrate is collected and the supernatant is taken, and the supernatant is added to a spray dryer, and the inlet air temperature is set to 120-180°C, the outlet air temperature is set to 60-90°C, and the feed rate is set to 5-20ml / min to obtain the Eucommia male flower powder, thereby completing the enzymatic hydrolysis and drying treatment of the Eucommia male flower.

6. The Eucommia ulmoides male flower slices according to claim 5, characterized in that: The mass ratio of the water, eucommia male pollen, protease, cellulase and pectinase is (5-8):1:0.05:0.03:0.02, and the mass ratio of the enzymatic hydrolyzate to pure water is 6:

4.

7. The Eucommia ulmoides male flower slices according to claim 1, characterized in that: The filler is starch or lactose.

8. The Eucommia ulmoides male flower slices according to claim 1, characterized in that: The adhesive is hydroxypropyl methylcellulose or povidone.

9. The Eucommia ulmoides male flower slices according to claim 1, characterized in that: The lubricant is magnesium stearate or talc.

10. A method for preparing the Eucommia ulmoides male flower slices according to any one of claims 1 to 9, characterized in that: The following steps are involved: Step 1: Weigh the pretreated giant salamander peptide powder and sea cucumber intestinal peptide powder, micronized rapeseed pollen, enzymatically dried eucommia male flower powder, filler, lubricant and adhesive as needed, and put them into a three-dimensional motion mixture, and stir at 20-30 r / min for 30 minutes to obtain a mixed powder; Step 2: Add the mixed powder and pure water into a mixer, wherein the mass ratio of the mixed powder to pure water is 1:(0.2-0.4), stir at 400-500 r / min for 10-15 minutes to obtain a soft material, and granulate through a 16-20 mesh sieve; Step 3: Place the granules in a rotary tablet press, set the speed to 20-40 rpm and the pressure to 10-20 KN, and place them in a fluidized bed coater for coating to complete the preparation of giant salamander peptide Eucommia male flower tablets.

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