Traditional Chinese medicine composition for regulating spleen and stomach and preparation method thereof

Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for regulating spleen and stomach and a preparation method thereof. The traditional Chinese medicine composition for regulating the spleen and the stomach comprises the following raw materials in parts by weight: 15-25 parts of hawthorn, 35-45 parts of semen raphani, 15-25 parts of poria cocos, 4-6 parts of endothelium corneum gigeriae galli, 8-12 parts of sea-buckthorn, 8-12 parts of rhizoma polygonati, 15-25 parts of coix seeds, 15-25 parts of astragalus membranaceus, 15-25 parts of pericarpium citri reticulatae, 4-6 parts of ageratum and 2-4 parts of stachyose. According to the traditional Chinese medicine composition, hawthorn and semen raphani are used as main materials for promoting digestion and relieving stasis, poria cocos and coix seeds are used as auxiliary materials for tonifying spleen and eliminating dampness, astragalus membranaceus and rhizoma polygonati are used for tonifying qi and nourishing yin, pericarpium citri reticulatae and ageratum are used for regulating qi and resolving dampness, endothelium corneum gigeriae galli and sea-buckthorn are used for enhancing digestion and activating blood, and stachyose is used for regulating intestinal The traditional Chinese medicine composition has the multiple effects of tonifying spleen, promoting digestion, clearing damp, regulating qi, tonifying deficiency and the like, and is suitable for various symptoms such as weakness of spleen and stomach, indigestion, internal resistance of damp turbidity and the like.

Description

Technical Field

[0001] The present invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for regulating the spleen and stomach and a preparation method thereof. Background Art

[0002] Spleen and stomach dysfunction is a common health issue in modern society, manifesting primarily as indigestion, bloating, diarrhea, constipation, and loss of appetite. The fast pace of modern life, irregular diets, high-fat and high-sugar diets, and high levels of stress can increase the burden on the spleen and stomach, leading to a range of sub-health conditions and even chronic diseases. Traditional Chinese Medicine considers the spleen and stomach to be the foundation of acquired health. The strength of their function directly influences the production of Qi and blood, the transportation of food and water essences, and the rise and fall of Qi throughout the body. Therefore, regulating the spleen and stomach plays a crucial role in TCM health preservation and treatment.

[0003] At present, there are many kinds of Chinese medicine compositions for regulating the spleen and stomach on the market, but most of them have problems such as single formula, limited efficacy or rough preparation process. For example, the patent with application number CN201711092912.6 discloses a Chinese medicine composition for regulating the spleen and stomach, which only contains a few medicinal materials such as Panax notoginseng, Gastrodia elata, Poria cocos, Angelica dahurica and Gallus gallus domesticus. Although it has a certain spleen-strengthening and digestion-promoting effect, it has limited conditioning effect on complex spleen and stomach symptoms (such as spleen and stomach deficiency and cold, dampness and turbidity internal obstruction, qi stagnation and blood stasis, etc.). In addition, the preparation method of some Chinese medicine compositions in the prior art is not sophisticated enough, which may lead to loss of effective ingredients or insufficient drug stability, affecting clinical efficacy.

[0004] Therefore, there is an urgent need to develop a Chinese medicine composition with a scientific formula, comprehensive efficacy and optimized preparation process to more effectively regulate the spleen and stomach function and improve various symptoms caused by spleen and stomach disorders. Summary of the Invention

[0005] In order to solve the problems existing in the prior art, the present invention provides a traditional Chinese medicine composition for regulating the spleen and stomach, comprising the following raw materials in parts by weight: 15-25 parts of hawthorn, 35-45 parts of radish seeds, 15-25 parts of poria, 4-6 parts of chicken's gizzard lining, 8-12 parts of sea buckthorn, 8-12 parts of polygonatum, 15-25 parts of coix seed, 15-25 parts of astragalus, 15-25 parts of tangerine peel, 4-6 parts of poria and 2-4 parts of stachyose.

[0006] Preferably, the Chinese medicine composition for regulating the spleen and stomach comprises the following raw materials in parts by weight: 20 parts of hawthorn, 40 parts of radish seeds, 20 parts of poria, 5 parts of chicken gizzard lining, 10 parts of sea buckthorn, 10 parts of polygonatum, 20 parts of coix seed, 20 parts of astragalus, 20 parts of tangerine peel, 5 parts of poria and 3 parts of stachyose.

[0007] For ease of understanding of the present invention, the raw materials used in the present invention are described:

[0008] Hawthorn: tastes sour, sweet, and slightly warm in nature; it enters the spleen, stomach, and liver meridians; it has the effects of helping digestion and strengthening the stomach, promoting qi and dispersing blood stasis, clearing turbidity and lowering lipids.

[0009] Radish seeds: spicy and sweet, neutral in nature; enter the lung, spleen and stomach meridians; have the effects of digesting food, relieving bloating, lowering qi and resolving phlegm.

[0010] Poria: sweet, light in taste, neutral in nature; enters the heart, lung, spleen, and kidney meridians; has the effects of promoting diuresis and eliminating dampness, strengthening the spleen, and calming the mind.

[0011] Chicken Gizzard: sweet in taste, neutral in nature; enters the spleen, stomach, small intestine, and bladder meridians; has the effects of strengthening the stomach and aiding digestion, astringing semen and stopping nocturnal emission, and relieving stranguria and dissolving stones.

[0012] Sea buckthorn: tastes sour, astringent, and warm in nature; it enters the spleen, stomach, lung, and heart meridians; it has the effects of strengthening the spleen and digestion, relieving cough and expectoration, and promoting blood circulation and dispersing blood stasis.

[0013] Polygonatum: sweet in taste, neutral in nature; enters the spleen, lung and kidney meridians; has the effects of replenishing qi and nourishing yin, strengthening the spleen, moistening the lungs and benefiting the kidneys.

[0014] Job's tears: sweet, light, and cool in nature; enters the spleen, stomach, and lung meridians; has the effects of promoting water and dampness removal, strengthening the spleen and stopping diarrhea, removing numbness, discharging pus, and detoxifying and dispersing nodules.

[0015] Astragalus: sweet in taste, slightly warm in nature; enters the spleen and lung meridians; has the effects of strengthening the spleen and replenishing the middle, raising yang and lifting the sunken, benefiting the body's defense and consolidating the exterior, promoting urination, and expelling toxins and promoting tissue regeneration.

[0016] Tangerine peel: bitter, spicy, warm in nature; enters the lung and spleen meridians; has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm.

[0017] Huoxiang: spicy and warm in nature; enters the spleen, stomach and lung meridians; has the effects of removing dampness and invigorating the spleen, dispelling filth and harmonizing the stomach, relieving heat and releasing exterior.

[0018] Based on the same technical concept, another embodiment of the present invention is to provide a method for preparing a Chinese medicine composition for regulating the spleen and stomach, the preparation method comprising the following steps:

[0019] (1) All raw materials are cleaned and dried, and then crushed to obtain Chinese medicine powder;

[0020] (2) heating the honey to remove impurities, kill bacteria, evaporate water, and increase viscosity to obtain refined honey;

[0021] (3) mixing the Chinese medicinal powder with the refined honey and then blending to obtain a mass-like mixture;

[0022] (4) rolling the dough mixture into strips and pills, and then drying and packaging to obtain a traditional Chinese medicine composition for regulating the spleen and stomach.

[0023] Preferably, in step (1):

[0024] The number of cleanings is 3 to 5 times;

[0025] And / or, the drying temperature is 40-50° C., and the drying time is 2-3 hours.

[0026] Preferably, in step (1), the Chinese medicine powder is pulverized to pass through a 100-120 mesh sieve.

[0027] Preferably, in step (2), the heating temperature is 100-120°C.

[0028] Preferably, in step (3), the weight ratio of the Chinese medicinal powder to the refined honey is 1:1.2-1.5.

[0029] Preferably, in step (4), after rolling into strips and forming into pills, the weight of the obtained honey pills is 3 to 4 g / pill.

[0030] The beneficial effects of the present invention are:

[0031] The Chinese medicine composition and preparation method provided by the present invention have the following significant advantages:

[0032] 1. Scientifically formulated, comprehensive efficacy: The combination primarily incorporates hawthorn and radish seeds to aid digestion and resolve stagnation, supplemented by poria and coix seed to invigorate the spleen and dispel dampness, astragalus and polygonatum to replenish qi and nourish yin, tangerine peel and poria cocos to regulate qi and dissipate dampness, chicken gizzard lining and sea buckthorn to enhance digestion and blood circulation, and stachyose to regulate intestinal flora. These herbs work synergistically to strengthen the spleen, aid digestion, dispel dampness, regulate qi, and tonify deficiency. It is suitable for a variety of syndromes, including spleen and stomach deficiency, indigestion, and internal dampness.

[0033] 2. Optimized preparation process and stable efficacy: By precisely controlling the process parameters of raw material cleaning, drying, crushing and refining (such as drying temperature, crushing mesh size, refining temperature, etc.), the active ingredients are retained to the maximum extent, ensuring the stability of efficacy and uniformity of the preparation.

[0034] 3. Reasonable dosage form and easy to take: It adopts honey pill dosage form, which has a suitable taste and is easy to carry and take. At the same time, the adhesive effect of refined honey helps to delay the release of the drug and enhance the long-term conditioning effect.

[0035] 4. Significant clinical validation: Typical cases have shown that the composition can effectively improve symptoms such as indigestion, abdominal distension, diarrhea, constipation, and enhance the spleen and stomach's transportation and transformation functions. Problems such as sleep quality, metabolic function, and irregular menstruation that accompany some patients are also alleviated. DETAILED DESCRIPTION

[0036] To make the objectives, technical solutions, and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. Obviously, the embodiments described are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other implementations obtained by those of ordinary skill in the art without inventive effort are within the scope of protection of the present invention.

[0037] Example 1

[0038] This embodiment provides a method for preparing a Chinese medicine composition for regulating the spleen and stomach, characterized in that the preparation method comprises the following steps:

[0039] (1) Weigh the following raw materials: 150 g of hawthorn, 350 g of radish seeds, 150 g of poria, 40 g of chicken gizzard lining, 80 g of sea buckthorn, 80 g of polygonatum, 150 g of coix seed, 150 g of astragalus, 150 g of dried tangerine peel, 40 g of poria, and 20 g of stachyose. Rinse the above raw medicinal materials under running water three times to remove surface sediment and impurities. Spread the washed medicinal materials flat on a stainless steel tray, place in an oven, and dry at a constant temperature of 40°C for 3 hours until the moisture content of the medicinal materials is less than 8%, thereby obtaining dried medicinal materials.

[0040] (2) The dried medicinal materials are put into a grinder and crushed respectively, and passed through a 100-mesh sieve to obtain uniform fine powder, and then all the medicinal powders are mixed uniformly to obtain Chinese medicinal powder.

[0041] (3) Place high-quality honey in a stainless steel pot, heat to 100°C, and stir continuously for 10 minutes to remove foam and impurities. When the color of the honey deepens and the viscosity increases (the water content of the refined honey drops below 15%), stop heating and cool to 60°C for use to obtain refined honey.

[0042] (4) The Chinese medicine powder and the refined honey are mixed in a weight ratio of 1:1.2, stirred until a uniform mass mixture is formed, and the mass is placed in a pill making machine to roll and divide the mixture into strips to make honey pills of about 3 g each.

[0043] (5) Place the honey pills in a ventilated drying oven and dry them at 30°C for 24 hours until the surface is no longer sticky. Finally, pack them in aluminum-plastic blisters, with 10 pills per plate, and seal them for storage.

[0044] Example 2

[0045] This embodiment provides a method for preparing a Chinese medicine composition for regulating the spleen and stomach, characterized in that the preparation method comprises the following steps:

[0046] (1) Weigh 250g of hawthorn, 450g of radish seeds, 250g of poria, 60g of chicken gizzard lining, 120g of sea buckthorn, 120g of polygonatum, 250g of coix seed, 250g of astragalus, 250g of dried tangerine peel, 60g of agave hopanax, and 40g of stachyose. Rinse the above medicinal materials under running water for 5 times to remove surface sediment and impurities. Spread the washed medicinal materials on a stainless steel tray, place them in an oven, and dry them at a constant temperature of 50°C for 2 hours until the moisture content of the medicinal materials is less than 8%, thereby obtaining dried medicinal materials.

[0047] (2) The dried medicinal materials are put into a grinder and crushed respectively, and passed through a 120-mesh sieve to obtain uniform fine powder, and then all the medicinal powders are mixed uniformly to obtain Chinese medicinal powder.

[0048] (3) Place high-quality honey in a stainless steel pot, heat to 120°C, and stir continuously for 10 minutes to remove foam and impurities. When the color of the honey deepens and the viscosity increases (the water content of the refined honey drops below 15%), stop heating and cool to 60°C for later use to obtain the refined honey.

[0049] (4) The Chinese medicine powder and the refined honey are mixed in a weight ratio of 1:1.5, stirred until a uniform mass mixture is formed, and the mass is placed in a pill making machine to roll and split into strips to make honey pills of about 4 g each.

[0050] (5) Place the honey pills in a ventilated drying oven and dry them at 30°C for 24 hours until the surface is no longer sticky. Finally, pack them in aluminum-plastic blisters, with 10 pills per plate, and seal them for storage.

[0051] Example 3

[0052] This embodiment provides a method for preparing a Chinese medicine composition for regulating the spleen and stomach, characterized in that the preparation method comprises the following steps:

[0053] (1) Weigh the following raw materials: 200g hawthorn, 400g radish seeds, 200g poria, 50g chicken gizzard lining, 100g sea buckthorn, 100g polygonatum, 200g coix seed, 200g astragalus, 200g tangerine peel, 50g agave wormwood, and 30g stachyose. Rinse the above raw medicinal materials under running water three times to remove surface sediment and impurities. Spread the washed medicinal materials flat on a stainless steel tray, place in an oven, and dry at a constant temperature of 45°C for 2.5 hours until the moisture content of the medicinal materials is less than 8%, thereby obtaining dried medicinal materials.

[0054] (2) The dried medicinal materials are put into a grinder and crushed respectively, and passed through a 110-mesh sieve to obtain uniform fine powder, and then all the medicinal powders are mixed uniformly to obtain Chinese medicinal powder.

[0055] (3) Place high-quality honey in a stainless steel pot, heat to 110°C, and stir continuously for 10 minutes to remove foam and impurities. When the color of the honey deepens and the viscosity increases (the water content of the refined honey drops below 15%), stop heating and cool to 60°C for later use to obtain the refined honey.

[0056] (4) The Chinese medicine powder and the refined honey are mixed in a weight ratio of 1:1.3, stirred until a uniform mass mixture is formed, and the mass is placed in a pill making machine to roll and divide the mixture into strips to make honey pills of about 3 g each.

[0057] (5) Place the honey pills in a ventilated drying oven and dry them at 30°C for 24 hours until the surface is no longer sticky. Finally, pack them in aluminum-plastic blisters, with 10 pills per plate, and seal them for storage.

[0058] Typical Cases

[0059] In order to better understand the effect of the Chinese medicine composition for regulating the spleen and stomach of the present invention, the present invention selects the following typical cases for illustration (to protect privacy, the names are hidden and replaced with code names):

[0060] Case 1:

[0061] Name: Patient 1; Gender: Male; Age: 35 years old.

[0062] Chief Complaint: The patient previously weighed 69 kg and presented with symptoms of spleen and stomach deficiency and coldness, manifested by a greasy, white tongue coating, particularly worse in the mornings; a low abdominal temperature; cool lower extremities without sweating; a distended abdomen with bloating; general fatigue; and a lack of energy. Sleep was interrupted 1-2 times at night; stools were sticky, with a feeling of incomplete defecation and dark, clumpy stools. He also experienced occasional diarrhea after eating and recurrent lower back discomfort, accompanied by oral ulcers, susceptibility to inflammation, and dry mouth in the mornings.

[0063] Intervention measures: Oral administration of the Chinese medicine composition for regulating the spleen and stomach obtained in Example 3, for a course of 3 months, twice a day, one pill each time.

[0064] Efficacy observation:

[0065] 1. Improved intestinal function: bowel sounds become active, defecation time is shortened to 1-2 minutes, stool turns golden yellow and has a regular shape, and defecation is smooth.

[0066] 2. Abdominal symptoms are relieved: abdominal temperature rises, abdominal softness increases, the cold feeling in the lower limbs disappears, and blood circulation improves.

[0067] 3. Improved sleep quality: continuous sleep at night, dark circles fade, daytime fatigue disappears, and energy is abundant.

[0068] 4. Changes in weight and tongue: The weight dropped to 63kg, the tongue coating turned red, and the sticky feeling disappeared.

[0069] 5. Increased appetite: Appetite is significantly improved, the pleasure of eating increases, and weight does not rebound.

[0070] Case 2:

[0071] Name: Patient 2; Gender: Female; Age: 45 years old.

[0072] Chief complaint: Past history of food accumulation and bloating, especially after ingesting greasy food, accompanied by delayed gastric emptying and malabsorption, and limited food intake.

[0073] Intervention measures: Oral administration of the Chinese medicine composition for regulating the spleen and stomach obtained in Example 3, for a course of one month, twice a day, one pill each time.

[0074] Efficacy observation:

[0075] 1. Gastric motility is enhanced, and acid reflux symptoms basically disappear without relying on other methods for relief.

[0076] 2. Digestive efficiency is improved, and taking honey pills after occasionally eating difficult-to-digest food can quickly relieve the symptoms.

[0077] 3. The frequency of diarrhea is significantly reduced and the stool formation rate is increased.

[0078] Case 3:

[0079] Name: Patient 3; Gender: Female; Age: 36 years old.

[0080] Chief complaint: Previously diagnosed as gastroesophageal reflux, accompanied by belching, abdominal distension and a feeling of incomplete defecation.

[0081] Intervention measures: Oral administration of the Chinese medicine composition for regulating the spleen and stomach obtained in Example 3, for a course of 2 months, twice a day, one pill each time.

[0082] Efficacy observation:

[0083] 1. The frequency of bowel movements stabilizes to once a day, and the frequency of reflux attacks decreases from 2-3 times a week to once a month.

[0084] 2. Abdominal distension and belching symptoms are completely relieved.

[0085] 3. Smooth bowel movements and improved metabolic function.

[0086] Case 4:

[0087] Name: Patient 4; Gender: Female; Age: 28

[0088] Chief complaint: Recurrent attacks of seasonal gastritis, weak spleen and stomach, abdominal distension after meals, constipation with sticky and unformed stools.

[0089] Intervention measures: Oral administration of the Chinese medicine composition for regulating the spleen and stomach obtained in Example 3, for a course of 15 days, twice a day, one pill each time.

[0090] Efficacy observation:

[0091] 1. Improved gastrointestinal function: In the first week, flatulence increases and constipation is relieved; in the second week, stool becomes formed and the sticky feeling disappears.

[0092] 2. Reduce abdominal distension: No auxiliary measures are needed to promote digestion after meals.

[0093] 3. Gastritis has not recurred: the tolerance of the gastric mucosa has increased.

[0094] 4. Improved sleep quality.

[0095] Case 5:

[0096] Name: Patient 5; Gender: Female; Age: 44 years old.

[0097] Main complaints: constipation, stomachache, spleen and stomach weakness and irregular menstruation (small menstrual volume, dark color, blood clots and dysmenorrhea).

[0098] Intervention measures: Oral administration of the Chinese medicine composition for regulating the spleen and stomach obtained in Example 3, for a course of one month, twice a day, one pill each time.

[0099] Efficacy observation:

[0100] 1. The frequency of bowel movements improves to once a day, and the stool becomes formed.

[0101] 2. Symptoms of stomach pain, bloating and acid reflux have not recurred.

[0102] 3. The color of menstruation becomes lighter and the amount of blood clots decreases.

[0103] 4. Symptoms of dizziness and fatigue are alleviated.

[0104] Case 6:

[0105] Name: Patient 6; Gender: Female; Age: 54 years old.

[0106] Chief complaint: chronic acid reflux, belching, bloating and indigestion for 3 years, and occasional difficulty in defecation.

[0107] Intervention measures: Oral administration of the Chinese medicine composition for regulating the spleen and stomach obtained in Example 3, for a course of 15 days, twice a day, one pill each time.

[0108] Efficacy observation:

[0109] 1. Stomach bloating is reduced and food tolerance is improved.

[0110] 2. Symptoms of acid reflux and belching disappear, and appetite increases.

[0111] 3. Bowel movements are smooth and there is no digestive discomfort during the Spring Festival.

[0112] Case 7

[0113] Name: Patient 7; Gender: Male; Age: 21 years old.

[0114] Chief complaint: frequent diarrhea after eating, low weight due to malabsorption, and bad breath.

[0115] Intervention measures: Oral administration of the Chinese medicine composition for regulating the spleen and stomach obtained in Example 3, for a course of 10 days, twice a day, one pill each time.

[0116] Efficacy observation:

[0117] 1. Bad breath is significantly reduced.

[0118] 2. The frequency of diarrhea is reduced.

[0119] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any modifications or substitutions that can be easily conceived by a person skilled in the art within the technical scope disclosed in the present invention should be included in the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be based on the scope of protection of the claims.

Claims

1. A Chinese medicine composition for regulating the spleen and stomach, characterized in that: The invention comprises the following raw materials in parts by weight: 15-25 parts of hawthorn, 35-45 parts of radish seeds, 15-25 parts of poria, 4-6 parts of chicken's gizzard lining, 8-12 parts of sea buckthorn, 8-12 parts of polygonatum, 15-25 parts of coix seeds, 15-25 parts of astragalus, 15-25 parts of tangerine peel, 4-6 parts of poria and 2-4 parts of stachyose.

2. The Chinese medicine composition for regulating the spleen and stomach according to claim 1, wherein The invention comprises the following raw materials in parts by weight: 20 parts of hawthorn, 40 parts of radish seeds, 20 parts of poria, 5 parts of chicken's gizzard lining, 10 parts of seabuckthorn, 10 parts of polygonatum, 20 parts of coix seeds, 20 parts of astragalus, 20 parts of tangerine peel, 5 parts of poria and 3 parts of stachyose.

3. The method for preparing the Chinese medicine composition for regulating the spleen and stomach according to claim 1 or 2, characterized in that: The preparation method comprises the following steps: (1) All raw materials are cleaned and dried, and then crushed to obtain Chinese medicine powder; (2) heating the honey to remove impurities, kill bacteria, evaporate water, and increase viscosity to obtain refined honey; (3) mixing the Chinese medicinal powder with the refined honey and then blending to obtain a mass-like mixture; (4) rolling the dough mixture into strips and pills, and then drying and packaging to obtain a traditional Chinese medicine composition for regulating the spleen and stomach.

4. The method for preparing the Chinese medicine composition for regulating the spleen and stomach according to claim 3, wherein: In step (1): The number of cleanings is 3 to 5 times; And / or, the drying temperature is 40-50° C., and the drying time is 2-3 hours.

5. The method for preparing the Chinese medicine composition for regulating the spleen and stomach according to claim 3, wherein: In step (1), the Chinese medicine powder is pulverized and passed through a 100-120 mesh sieve.

6. The method for preparing the Chinese medicine composition for regulating the spleen and stomach according to claim 3, wherein: In step (2), the heating temperature is 100-120°C.

7. The method for preparing the Chinese medicine composition for regulating the spleen and stomach according to claim 3, wherein: In step (3), the weight ratio of the Chinese medicinal powder to the refined honey is 1:1.2-1.

5.

8. The method for preparing the Chinese medicine composition for regulating the spleen and stomach according to claim 3, wherein: In step (4), after rolling into strips and forming into pills, the weight of the obtained honey pills is 3 to 4 g / pill.