Consumable for aerosolizable formulations

Abstract

The present disclosure provides a consumable for an aerosolizable formulation wherein the consumable comprises: (i) one or more sensory agents wherein at least one sensory agent is a warming agent or a hemp thorn agent; (ii) a sweetener; and (iii) at least one compound which is an emulsifier. A method of forming an aerosol, an aerosolizable formulation comprising the consumable and an aerosol supply device comprising the aerosolizable formulation are also provided.

Description

Technical Field

[0001] The present disclosure relates to a consumable product for an aerosolizable formulation, in particular an aerosolizable formulation suitable for use with an electronic aerosol delivery system such as an electronic cigarette. The present disclosure also relates to uses of the consumable product, a container containing the formulation, and a method of generating an aerosol using the formulation. Background Art

[0002] Devices have been developed that allow users to replicate some of the smoking experience without having to use traditional cigarettes. In particular, devices such as electronic cigarettes have been developed that allow users to generate an artificial aerosol that can then be inhaled to replicate the smoking experience. Aerosols are typically produced by vaporizing a liquid containing nicotine and an aerosol-forming component such as glycerol. Vaporization occurs via a heater (or other atomizing component) powered by a power source such as a battery.

[0003] Other devices are also available that attempt to replicate the smoking experience without having to use traditional cigarettes. These devices may be referred to as tobacco heating devices because they generally have the ability to heat tobacco but not burn it.

[0004] Electronic cigarettes and tobacco heating devices may be collectively referred to as aerosol delivery devices or aerosol delivery systems. However, a potential disadvantage of such devices or systems, particularly electronic cigarettes, is that they may not fully replicate the sensory experience typically associated with smoking traditional cigarettes, which users of traditional cigarettes may find less than ideal.

[0005] It is therefore desirable to provide means for improving the sensory experience delivered by an aerosol delivery device / aerosol supply system so that it more closely replicates the sensory experience of smoking a cigarette. This can be achieved by improving one or more sensory properties of the aerosolizable formulation in the device so that it replicates smoking a traditional cigarette. Summary of the Invention

[0006] The present disclosure relates to combinations of ingredients that can be used in aerosolizable formulations to improve at least one sensory property thereof. In particular, the combination of one or more sensates, a sweetener, and an emulsifier (e.g., triacetin) provides a consumable product capable of improving at least one sensory property of an aerosolizable formulation, such that the formulation more closely replicates the experience of smoking a conventional cigarette when inhaled by the user. Thus, the improvement in sensory properties can be relative to a formulation without the combination of one or more sensates, a sweetener, and an emulsifier (e.g., triacetin), where the sensory property can be selected from taste, mouthfeel, and / or smoking experience. In one embodiment, the emulsifier, as defined in claim 1, is triacetin; however, the present disclosure is not limited to triacetin.

[0007] According to some embodiments described herein, there is provided a consumable for an aerosolizable formulation, wherein the consumable comprises: (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent; (ii) a sweetener; and (iii) at least one compound that is an emulsifier and is C4 to C 38 Hydrocarbon esters, C4 to C 38 Hydrocarbyl polyol, or polyoxyalkylene fatty acid ester. In some embodiments, compound (iii) has a boiling point of at least 200° C. at atmospheric pressure (760 mmHg; 101325 Pa). In some embodiments, (ii) is different from (iii).

[0008] According to some embodiments described herein, there is provided a consumable for an aerosolizable formulation, wherein the consumable comprises: one or more sensates, wherein at least one sensate is a warming agent or a tingling agent; a sweetener; and triacetin, optionally wherein the weight ratio of the one or more sensates to the sweetener is greater than about 1:1 to about 3:1.

[0009] According to some embodiments described herein, there is provided an aerosolizable formulation for use in an aerosol supply system, comprising a consumable as defined herein, a carrier, and optionally nicotine.

[0010] According to some embodiments described herein, there is provided an aerosolizable formulation or an aerosol-generating system comprising a consumable as defined herein, an aerosol-former material, one or more binders, and optionally a plant material.

[0011] According to some embodiments described herein, there is provided an aerosolizable formulation for an aerosol supply system comprising a consumable as defined herein, wherein the formulation comprises from about 0.0001 wt % to about 5 wt % of one or more sensates, and from greater than about 1 wt % to less than about 35 wt % of an emulsifier (e.g., triacetin).

[0012] According to some embodiments described herein, there is provided an aerosolizable formulation for an aerosol supply system comprising a consumable as defined herein, wherein the formulation comprises from about 0.001 wt % to about 1 wt % of one or more sensates, and greater than about 5 wt % to less than about 20 wt % of an emulsifier (e.g., triacetin).

[0013] According to some embodiments described herein, there is provided an article comprising an aerosolizable formulation as defined herein.

[0014] According to some embodiments described herein, there is provided an aerosol supply system comprising an aerosol supply device and an article as defined herein.

[0015] According to some embodiments described herein, there is provided a method for forming an aerosol, the method comprising providing an aerosolizable formulation as defined herein and aerosolizing the formulation.

[0016] According to some embodiments described herein, there is provided a method for forming an aerosol, the method comprising providing an aerosol generating system or an aerosol supply system as defined herein, and aerosolizing a formulation and / or consumable in the system.

[0017] According to some embodiments described herein, there is provided a sealed container containing an article as defined herein, optionally wherein the container is hermetically sealed and formed from a material that inhibits or prevents the passage of ultraviolet light therethrough.

[0018] According to some embodiments described herein, there is provided the use of about 0.0001% to about 5% by weight of one or more sensates in combination with a sweetener and a compound for modulating at least one sensory characteristic of an aerosolizable formulation or an aerosol-generating system, wherein at least one sensate is a warming or tingling agent and the compound is an emulsifier, wherein the compound has a boiling point of at least 200° C. at atmospheric pressure.

[0019] According to some embodiments described herein, there is provided a use of about 0.0001% to about 5% by weight of one or more sensates in combination with a sweetener and a compound for modulating at least one sensory characteristic of an aerosolizable formulation or an aerosol generating system, wherein at least one sensate is a warming agent or a tingling agent, the compound is an emulsifier, and is C4 to C 38 Hydrocarbon esters, C4 to C 38 Hydrocarbyl polyols, or polyoxyalkylene fatty acid esters.

[0020] According to some embodiments described herein, there is provided use of about 0.001% to about 1% by weight of one or more sensates in combination with a sweetener and triacetin for improving at least one sensory characteristic of an aerosolizable formulation, wherein at least one sensate is a warming or tingling agent.

[0021] According to some embodiments, there is provided the use of an emulsifier for modifying the mouthfeel of an aerosolizable formulation or an aerosol-generating system, the emulsifier having a boiling point of at least about 200°C at atmospheric pressure, wherein the mouthfeel is modified to replicate one or more sensations of smoking a combustible tobacco product, preferably a cigarette.

[0022] According to some embodiments, there is provided a use of an emulsifier for adjusting the mouthfeel of an aerosolizable formulation or an aerosol generating system, the emulsifier being C4 to C 38 Hydrocarbon esters, C4 to C 38Hydrocarbyl polyols, or polyoxyalkylene fatty acid esters, wherein the mouthfeel is adjusted to replicate one or more sensations of smoking a combustible tobacco product, preferably a cigarette.

[0023] According to some embodiments described herein, there is provided a use of about 0.0001% to about 5% by weight of a warming or tingling agent in combination with a sweetener and a compound in a tobacco-flavored aerosolizable formulation or an aerosol-generating system for adjusting the tobacco flavor intensity of a consumable in the formulation or system, the compound being an emulsifier, wherein the emulsifier compound has a boiling point of at least about 200° C. at atmospheric pressure.

[0024] According to some embodiments described herein, there is provided the use of about 0.001% to about 0.05% by weight of a warming or tingling agent in combination with a sweetener and triacetin in a tobacco-flavored aerosolizable formulation for adjusting the tobacco flavor intensity of the formulation.

[0025] According to some embodiments described herein, there is provided a use of about 0.0001% by weight to about 5% by weight of one or more sensates in combination with a sweetener and an emulsifier in a tobacco-flavored aerosolizable formulation for adjusting the tobacco flavor intensity of the formulation, wherein at least one sensate is a warming agent or a tingling agent, wherein the emulsifier has a boiling point of at least about 200° C. at atmospheric pressure and / or is C4 to C 38 Hydrocarbon esters, C4 to C 38 Hydrocarbyl polyols, or polyoxyalkylene fatty acid esters.

[0026] According to some embodiments described herein, there is provided the use of about 0.001% to about 1% by weight of one or more sensates in combination with a sweetener and triacetin in a tobacco-flavored aerosolizable formulation for adjusting the tobacco flavor intensity of the formulation, wherein at least one sensate is a warming agent or a tingling agent.

[0027] These and other features, aspects and advantages of the present disclosure will become apparent from the following detailed description and accompanying drawings. The present invention includes any combination of two, three, four or more of the above-described embodiments and any combination of two, three, four or more features or elements shown in this disclosure, regardless of whether such features or elements are explicitly combined in the specific embodiment description herein. This disclosure is intended to be read as a whole, such that any separable features or elements of the disclosed invention in any of its various aspects and embodiments should be considered combinable unless the context clearly dictates otherwise. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Having thus described various aspects of the present disclosure in the foregoing general terms, the description will now proceed with reference to the accompanying drawings, which are not necessarily drawn to scale. The drawings are merely illustrative and are not to be construed as limiting the present disclosure.

[0029] Figure 1 Schematic diagram of an exemplary aerosol supply system.

[0030] Figure 2 Figure 3 shows the product development test results from Experiment 3.

[0031] Figure 3 Figure 3 shows the product development test results from Experiment 3. DETAILED DESCRIPTION

[0032] It should be understood that the present invention is not limited to the specific configurations, process steps, and materials disclosed herein, as these configurations, process steps, and materials may vary slightly. It should also be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting, as the scope of the present invention will be limited only by the appended claims and their equivalents.

[0033] As used in this specification and claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. References to "dry weight %" or "on a dry weight basis" refer to the weight of the dry ingredients (i.e., all ingredients excluding water or carrier). References to "wet weight" refer to the weight of the formulation or composition including water or carrier. Unless otherwise indicated, references to "weight %" of a formulation or composition reflect the total wet weight (i.e., including water / carrier) of the formulation or composition.

[0034] In this specification, unless otherwise indicated, the term "about" as used to modify the amount of an ingredient in a formulation of the invention or used in a method of the invention refers to variations in the numerical amount that may occur, for example, due to typical measurement and liquid handling procedures used to prepare concentrates or use solutions in the real world; due to inadvertent errors in these procedures; due to differences in the manufacture, source, or purity of the ingredients used to prepare the formulation or perform the method; and the like. The term "about" also encompasses amounts that differ due to different equilibrium conditions of the formulation or composition resulting from a particular initial mixture. Whether or not modified by the term "about," the claims include equivalents to the stated amounts.

[0035] As mentioned in the background above, aerosol delivery devices or systems generally allow users to replicate portions of the smoking experience without having to use traditional cigarettes. Specifically, aerosol delivery systems are designed to generate an artificial aerosol that users can inhale to replicate the smoking experience. However, the aerosol generated by such systems does not fully replicate the sensory experience typically associated with smoking traditional cigarettes.

[0036] The "sensory gap" between the use of current aerosolizable formulations and smoking conventional cigarettes includes one or more of taste, mouthfeel, and smoking experience. It has surprisingly been discovered that the combination of the compounds of the present claims, namely one or more sensates, at least one of which is a warming / tingling agent; an emulsifier as defined in claim 1 (e.g., triacetin); and a sweetener, can modulate, for example, improve, at least one of these cigarette smoking sensations and thereby reduce this "sensory gap."

[0037] As will be understood by those skilled in the art, an "aerosolizable formulation" is a formulation that is capable of generating an aerosol, for example, when energy is imparted by heating, radiation, or any other means. An "aerosolizable formulation," i.e., an aerosol-generating formulation, may, for example, be in the form of a solid, liquid, or semi-solid (such as a gel), which may or may not contain one or more active substances and / or flavoring agents. In a preferred embodiment, the aerosolizable formulation is in the form of a liquid or a gel.

[0038] Cigarettes are used herein as exemplary combustible tobacco products; those skilled in the art will appreciate that the present disclosure is not limited to replicating one or more sensations of smoking cigarettes and can be equally applicable to replicating one or more sensations of smoking other combustible tobacco products such as cigars. The sensations can include taste, mouthfeel, smoking experience, or a combination thereof.

[0039] Taste is the sensation and / or perception of flavoring, and in smoking, flavoring is primarily delivered through aroma. When a user inhales an aerosol from a tobacco-flavored formulation (e.g., tobacco-flavored e-liquid or gel), the aroma is expected to be tobacco-like and to deliver a richness and complexity comparable to smoking a cigarette.

[0040] Aerosol body and mouthfeel are the physical sensations experienced by a user in the oral cavity during and after smoking a cigarette. Cigarette smoke is often associated with a "fullness" in the mouth and leaves a perceptible coating in the mouth after use. The aftertaste of smoking a cigarette can be described as lingering or addictive. In the present disclosure, the aerosolizable formulations and aerosol-generating systems as defined herein provide an aerosol body and mouthfeel comparable to smoking a conventional cigarette. Mouthfeel can also include irritation and / or throat harshness, as well as dryness of the mouth and a mouthful of steam.

[0041] The smoking experience includes the desired nicotine sensory experience of smoke and builds up the sensory experience to the level of sensory saturation on a mouthful by mouthful basis. The nicotine sensation includes the nicotine " kick " (i.e., physiological reaction, sometimes referred to as " buzzing feeling") and impact (i.e., wherein the user experiences stimulation and taste), and is an indispensable part of the cigarette smoking experience. Sweeteners have been shown to reduce / soften the nicotine sensation in the present disclosure, while warming agents or tingling agents (such as Symheat) provide cumulative stimulation, but this is astringent and rough. On the contrary, the aerosolizable formulations of the present disclosure provide the smoking experience of replicating cigarettes. The smoking experience can also include first puff satisfaction and visible vapor.

[0042] Surprisingly, the consumables of the present disclosure improve the sensory experience of aerosolizable formulations when used in an aerosol supply device. In addition, the level of the compound in the consumable can be adjusted to customize the flavoring intensity according to the consumer's preferences. This is beneficial because it maximizes the conversion and attraction of the aerosol supply system as a substitute for cigarettes or other combustible tobacco products. Together with this range of smoking sensations, the consumables can be combined with a range of flavorings and substrates (such as e-liquids). The consumables can be used, for example, with tobacco-flavored e-liquids or similarly with mint / menthol-flavored e-liquids or any plant material, for example in the form of a gel.

[0043] For ease of reference, these and other aspects of the present invention are now discussed under appropriate section headings. However, the teachings under each section are not necessarily limited to each specific section. In other words, specific sections of the specification should not be read separately from other sections.

[0044] The ranges provided herein relate to preferred amounts of each component. Each of these ranges can be taken alone or in combination with one or more other component ranges to provide preferred embodiments of the present invention.

[0045] Consumables for aerosolizable formulations

[0046] The present invention provides a consumable for an aerosolizable formulation, i.e., a consumable suitable for use in an aerosolizable formulation. The consumable may be as defined in claim 1; the consumable comprises: (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent; (ii) a sweetener; and (iii) at least one compound which is an emulsifier and is C4 to C 38 Hydrocarbon esters, C4 to C 38 Hydrocarbyl polyol, or polyoxyalkylene fatty acid ester. Compound (iii) may have a boiling point of at least about 200° C. at atmospheric pressure, but the present disclosure is not limited in this respect.

[0047] Without being bound by theory, it is believed that the emulsifying properties of compound (iii) are important for providing one or more replications of the smoking sensation. Those of ordinary skill in the art will readily understand the term "emulsifier". It refers to a compound that stabilizes an emulsion, i.e., a compound that promotes the suspension of one liquid in another. Emulsifiers are used in many consumables, including food, cosmetics, and pharmaceuticals.

[0048] The basic structure of an emulsifier (emulsifier or emulsifying agent) includes a hydrophobic part (usually a long-chain fatty acid) and a hydrophilic part (which may be charged or uncharged). The hydrophobic part of the emulsifier dissolves in the oil phase, and the hydrophilic part dissolves in the water phase, forming a dispersion of small oil droplets. In the context of the present disclosure, the emulsifier can be C4 to C 38 Hydrocarbon esters, C4 to C 38 Hydrocarbyl polyols, or polyoxyalkylene fatty acid esters. The emulsifying properties of these compounds can contribute to the observed modulation of mouthfeel, so as to replicate one or more sensations experienced when smoking a combustible tobacco product (e.g., a cigarette). The humectant compound (iii) can, for example, be a contributor to the mouth coating and / or "fullness" (i.e., aerosol body sensation) in the mouth perceived after use, each of which is modulated to replicate smoking, for example, a traditional cigarette. The emulsifier compound (iii) can also be a contributor to the punch or throat kick of the product.

[0049] As described herein, a consumable for an aerosolizable formulation is also provided, wherein the consumable comprises: one or more sensates, wherein at least one sensate is a warming or tingling agent; a sweetener; and triacetin, optionally wherein the weight ratio of the one or more sensates to the sweetener is greater than about 1:1 to about 3:1. In some embodiments, a consumable for an aerosolizable formulation is provided, wherein the consumable comprises: one or more sensates, wherein at least one sensate is a warming or tingling agent; a sweetener; and triacetin, wherein the weight ratio of the one or more sensates to the sweetener is greater than about 1:1 to about 3:1. The aerosolizable formulation is configured for use in an aerosol delivery system. Such systems are discussed further below.

[0050] Sensate

[0051] The consumables of the present disclosure contain one or more sensates. At least one sensate is a warming agent or a tingling agent. The terms "sensate" or "sensate compound," as used interchangeably herein, refer to compounds that trigger a sensation mediated by the user's trigeminal nerve.

[0052] The use of sensate compounds is well documented in the food and pharmaceutical industries, and the sensations triggered include cooling, warming, and tingling. When used in aerosolizable formulations, such sensations should be experienced in the user's mouth, nose, and / or skin. The present disclosure is not limited in this regard, although sensations experienced in the mouth and / or nose are preferred. The terms "cooling," "warming," and "tingling" are well understood in the art.

[0053] Cooling agents, warming agents, and tingling agents are each typically small organic molecules that provide a cooling, warming, or tingling sensation to the user upon contact with the oral cavity, nasal cavity, and / or skin. This sensation falls under the umbrella of chemical sensation and is produced by the activation of certain receptors in the skin and / or mucous membranes by small organic molecules. Therefore, the experience of cooling, warming, and / or tingling sensations depends on the user's chemical perception. Chemical perception is also referred to in the art as "common chemical perception" or trigeminal chemical perception because it generally refers to sensations mediated by the trigeminal nerve and is an element of the somatosensory system, distinguishing them from smell (smell) and taste.

[0054] At least one sensate in the consumable of the present invention is a warming agent or a tingling agent. The warming agent or tingling agent can be selected from the group consisting of vanillin, sanshool, piperine, allyl isothiocyanate, cinnamylphenylpropyl compound, ethyl ester, and combinations thereof, or the warming agent or tingling agent can be an extract from at least one of the following: horseradish oil, ginger oil, black pepper, long pepper, Sichuan pepper, red pepper, Uzazi, or mustard oil.

[0055] Vanilloids are compounds with a vanillyl group, and many vanilloids bind to transient receptor potential vanilloid type 1, or TRPV1, receptors, which are ion channels that naturally respond to stimuli. TRPV1 is therefore a component of the somatosensory system of mammals. Vanilloids include capsaicin (8-methyl-N-vanillyl-6-nonenamide) and norvanillidine, as well as 3-phenylpropyl homovanillate (the main component of SymHeat PV used in the examples herein). Other vanilloids include gingerol, zingerone, and shogaol, as well as vanillyl ethyl ether, vanillyl propyl ether, vanillyl butyl ether, and vanillyl butyl ether acetate. The chemical structures of capsaicin, 3-phenylpropyl homovanillate, gingerol, [6]-shogaol, and zingerone are shown in Appendix 1 along with vanillyl butyl ether.

[0056] Sanshool is exemplified by hydroxy-α-sanshool, a compound responsible for the numbness and tingling sensations caused by consuming Sichuan peppercorns and Uzazi. The term "sanshool" comes from the Japanese word for Japanese pepper, and the suffix "ol" means "alcohol." It is an agonist of TRPV1 and TRPA1 (ion channels best known as sensors of pain, cold, and itching in humans and other mammals). Its chemical structure is shown in Appendix 1.

[0057] Cinnamylphenylpropyl compounds share the common structural characteristics of aromatically substituted primary alcohols / aldehydes / esters. They include 3-phenylpropyl cinnamate and 3-phenyl-1-propanol, each of which has a spicy and balsamic odor, and 3-phenylpropyl isobutyrate, which has a fruity and off-flavor. In some embodiments, the cinnamylphenylpropyl compound is selected from 3-phenylpropyl cinnamate, 3-phenyl-1-propanol, and combinations thereof.

[0058] In some embodiments, the warming or tingling agent is selected from the group consisting of vanilloids, sanshool, piperine, cinnamylphenylpropyl compounds, ethyl esters, and combinations thereof, or the warming or tingling agent is an extract from at least one of horseradish oil, mustard oil, ginger oil, black pepper, long pepper, Sichuan pepper, bell pepper, or Uzazi.

[0059] In some embodiments, the warming or tingling agent is selected from the group consisting of vanilloids, piperine, cinnamylphenylpropyl compounds, ethyl esters, and combinations thereof, or the warming or tingling agent is an extract from at least one of ginger oil, black pepper, piper longum, or bell pepper.

[0060] In some embodiments, the warming or tingling agent comprises a vanillin, for example, the warming or tingling agent may comprise a combination of vanillin and a cinnamylphenylpropyl compound. In some embodiments, the warming or tingling agent is a vanillin, preferably 3-phenylpropyl homovanillate.

[0061] In some embodiments, the warming or tingling agent is selected from the group consisting of vanillyl ethyl ether, vanillyl propyl ether, 3-phenylpropyl homovanillate, capsaicinoids, gingerols (e.g., [6]-gingerol, [8]-gingerol,

[10] -gingerol and / or

[12] -gingerol), vanillyl butyl ether, vanillyl butyl ether acetate, sanshool, piperine, zingerone, shogaol (e.g., (6)-shogaol), allyl isothiocyanate, and combinations thereof, or the warming or tingling agent is an extract from at least one of horseradish oil, ginger oil, black pepper, long pepper, Sichuan pepper, bell pepper, Uzazi, or mustard oil.

[0062] In some embodiments, the warming or tingling agent is selected from vanillyl ethyl ether, vanillyl propyl ether, vanillyl butyl ether, vanillyl butyl ether acetate, 3-phenylpropyl homovanillate, and combinations thereof.

[0063] In some embodiments, the warming or tingling agent is selected from the group consisting of vanilloids, gingerols (e.g., [6]-gingerol, [8]-gingerol,

[10] -gingerol and / or

[12] -gingerol), zingerone, shogaol (e.g., (6)-shogaol), and combinations thereof, or the warming or tingling agent is an extract of ginger oil.

[0064] Where appropriate, all embodiments include all enantiomers and tautomers of the compounds. One of ordinary skill in the art will recognize compounds having optical properties (one or more chiral carbon atoms) or tautomeric characteristics. The corresponding enantiomers and / or tautomers can be separated / prepared by methods known in the art.

[0065] Some compounds may also exist as stereoisomers and / or geometric isomers, e.g., they may have one or more asymmetric and / or geometric centers and, therefore, may exist as two or more stereoisomers and / or geometric forms. Where appropriate, all embodiments include the use of all individual stereoisomers and geometric isomers of those compounds, and mixtures thereof. The terms used in the claims encompass these forms. Piperine, for example, has four geometric isomers, including piperine, isopiperine, and isopiperine. As used herein, the term "piperine" refers to all individual geometric isomers and mixtures thereof.

[0066] In some embodiments, the one or more sensate agents consist of a warming agent and a tingling agent.

[0067] In some embodiments, the one or more sensate agents consists of a warming agent.

[0068] In some embodiments, the one or more sensate agents consists of a tingling agent.

[0069] The one or more defined sensates may be present in the consumable in an amount of about 0.001% to about 10% by weight, based on the total weight of the consumable. As will be understood by one of ordinary skill in the art, this concentration range applies to the total amount of sensates (e.g., warming or tingling agents and optional cooling agents). The inclusion of cooling agents is discussed further below.

[0070] A concentration range of about 0.001% to about 10% by weight also applies to the above definition of one or more sensates. For example, a consumable may contain about 0.001% to about 10% by weight of one or more sensates, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent is selected from the group consisting of vanilloids, sanshool, piperine, cinnamylphenylpropyl compounds, ethyl esters, and combinations thereof, or an extract from at least one of the following: ginger oil, black pepper, long pepper, Sichuan pepper, red pepper, or Uzazi. Preferably, the warming or tingling agent comprises a vanilloid, such as 3-phenylpropyl homovanillate.

[0071] In some embodiments, one or more sensates as defined herein are present in the consumable in an amount of from about 0.001 wt % to about 5 wt %, such as from about 0.001 wt % to about 2.5 wt %, preferably from about 0.001 wt % to about 1 wt %, more preferably from about 0.001 wt % to about 0.5 wt %, based on the total weight of the consumable. In some particularly preferred embodiments, one or more sensates as defined herein are present in the consumable in an amount of from about 0.001 wt % to about 0.25 wt %.

[0072] In some embodiments, the warming or tingling agent is present in a concentration of about 0.0001 wt % to about 5 wt % based on the total weight of the consumable, such as about 0.0001 wt % to about 3 wt %, preferably about 0.0001 wt % to about 2.5 wt % based on the total weight of the consumable.

[0073] In some embodiments, the warming or tingling agent is present in a concentration of about 0.0001% to about 5% by weight, based on the total weight of the aerosolizable formulation, such as about 0.0001% to about 3% by weight, preferably about 0.0001% to about 2.5% by weight, and more preferably about 0.0001% to about 1% by weight, based on the total weight of the aerosolizable formulation. In some embodiments, the warming or tingling agent is present in a concentration of about 0.0001% to about 0.05% by weight, based on the total weight of the aerosolizable formulation. These concentration ranges can be combined with any of the above-mentioned concentrations for the total amount of sensate.

[0074] Preferably, the warming or tingling agent is present in a concentration of about 0.0001% to about 0.025% by weight, based on the total weight of the aerosolizable formulation. More preferably, the warming or tingling agent is present in a concentration of about 0.0001% to about 0.025% by weight, based on the total weight of the aerosolizable formulation, and is selected from the group consisting of vanillin, sanshool, piperine, cinnamylphenylpropyl compounds, ethyl esters, and combinations thereof, or the warming or tingling agent is an extract from at least one of: ginger oil, black pepper, long pepper, Sichuan pepper, red pepper, or Uzazi, such as vanillin.

[0075] Alternative preferred embodiments are those wherein the warming or tingling agent is present at a concentration of about 0.0001 wt % to about 5 wt %, based on the total weight of the aerosolizable formulation, and is selected from the group consisting of vanillin, sanshool, piperine, cinnamylphenylpropyl compounds, ethyl esters, and combinations thereof, or the warming or tingling agent is an extract from at least one of ginger oil, black pepper, long pepper, Sichuan pepper, red pepper, or Uzazi, such as vanillin.

[0076] In some embodiments, the one or more sensates consist of a warming agent or a tingling agent such that the "total" concentration of the one or more sensates is from about 0.0001 wt % to about 5 wt % based on the total weight of the consumable, such as from about 0.0001 wt % to about 3 wt %, preferably from about 0.0001 wt % to about 2.5 wt %, more preferably from about 0.0001 wt % to about 1 wt % based on the total weight of the consumable.

[0077] In some embodiments, the one or more sensate agents consist of a warming agent or a tingling agent such that the "total" concentration of the one or more sensate agents is from about 0.0001 wt % to about 1 wt %, preferably from about 0.0001 wt % to about 0.5 wt %, and more preferably from about 0.0001 wt % to about 0.25 wt %, based on the total weight of the aerosolizable formulation.

[0078] In some embodiments, the one or more sensates further comprise a cooling agent. The term "cooling agent" is as defined above. It may be menthol or a cooling agent that is a compound of formula (I) or a salt and / or solvate thereof.

[0079]

[0080] wherein X is hydrogen or OR', wherein R' is an alkyl or alkenyl group which, together with R1, forms a three- to five-membered heterocyclic group, wherein the heterocyclic group is optionally substituted with one or more substituents selected from the group consisting of OH, O-alkyl, alkyl-OH, alkyl-O-alkyl, NH2, NH-alkyl, N-(alkyl)2, NO2, and CN; and wherein R1 and R2 are each independently selected from the group consisting of hydrogen, OH, OR a 、C(O)NR b R c and C(O)OR b R c ; and when a double bond is present, R2 is absent;

[0081] where R a Alkyl, alkenyl, C(O)R f group or C(O)-alkyl-C(O)R f A group wherein the alkyl and alkenyl groups are optionally substituted with one or more substituents selected from the group consisting of OH, O-alkyl, NH2, NH-alkyl, N-(alkyl)2, NO2, and CN; and wherein R f is alkyl, alkenyl, OH, O-alkyl, NH2, NH-alkyl, or N-(alkyl)2, wherein alkyl and alkenyl are optionally substituted with one or more substituents selected from the group consisting of OH, O-alkyl, NH2, NH-alkyl, N-(alkyl)2, NO2, and CN;

[0082] where R b and Rc are each independently hydrogen, alkyl, alkenyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, wherein the alkyl, alkenyl, aryl, and heteroaryl groups are optionally substituted with one or more substituents selected from the group consisting of OH, O-alkyl, NH2, NH-alkyl, N-(alkyl)2, NO2, CN, and C(O)R f .

[0083] In some embodiments, X is hydrogen.

[0084] In some embodiments, X is OR', wherein R' is an alkyl or alkenyl group that, together with R1, forms a three- to five-membered heterocyclyl group, wherein the heterocyclyl group is optionally substituted with OH, O-alkyl, or alkyl-OH. In some embodiments, X is OR', wherein R' is an alkyl group that, together with R1, forms a four- to five-membered heterocyclyl group, wherein the heterocyclyl group is optionally substituted with alkyl-OH. In some embodiments, X is OR', wherein R' is an alkyl group that, together with R1, forms a four- to five-membered heterocyclyl group, wherein the heterocyclyl group is optionally substituted with alkyl-OH, and wherein R1 is OR a , where R a is alkyl, and wherein R2 is absent or is hydrogen.

[0085] In some embodiments, R1 is selected from OH, OR a and C(O)NR b R c , and R2 is absent or selected from OH and OR a In some embodiments, R1 is OH. In some embodiments, R1 is OH, and R2 is selected from OH and OR a .

[0086] In some embodiments, X is hydrogen, and R1 is selected from OH, OR a and C(O)NR b R c R2 is absent or selected from OH and OR a In some embodiments, X is hydrogen, R1 is selected from OR a and C(O)NR b R c , and R2 is absent or selected from OH and OR a .

[0087] In some embodiments, R1 is OR a , and R a R2 may be hydrogen.

[0088] In some embodiments, R1 is OR a , and R aC(O)R f group or C(O)-alkyl-C(O)R f Group, where R f is alkyl optionally substituted with one or more OH substituents, or R f R2 may be hydrogen.

[0089] In some embodiments, R1 is C(O)NR b R c , where R b and R c Each is independently hydrogen, alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl. In some embodiments, R1 is C(O)NR b R c , and R b and R c At least one of R2 is hydrogen.

[0090] In some embodiments, R1 is C(O)NR b R c , where R b is hydrogen, and R c is selected from the group consisting of alkyl, aryl, aralkyl and heteroaralkyl. R2 may be hydrogen.

[0091] As used herein, the term "alkyl" includes saturated straight and branched chain alkyl groups, which may be substituted (single or multiple) or unsubstituted. In some embodiments, the alkyl group is C 1-10 In some embodiments, the alkyl group is C 1-8 In some embodiments, the alkyl group is C 1-6 In some embodiments, the alkyl group is C 1-3 Alkyl. In some embodiments, alkyl includes, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, and hexyl. In some embodiments, alkyl includes methyl, ethyl, propyl, or isopropyl.

[0092] As used herein, the term "alkenyl" includes unsaturated straight and branched chain alkenyl groups, which may be substituted (single or multiple) or unsubstituted. In some embodiments, alkenyl is C 2-10 In some embodiments, alkenyl is C 2-8 In some embodiments, alkenyl is C 2-6 In some embodiments, alkenyl is C 2-3 Alkenyl.

[0093] As used herein, the term "aryl" refers to a C 6-12Aryl, which may be substituted (single or multiple) or unsubstituted. Typical examples include phenyl and naphthyl. In some embodiments, aryl is phenyl.

[0094] The term "aralkyl" is used as a combination of the terms alkyl and aryl as given above. For example, an aryl group can be formed by a diradical alkylene bridge (-CH2-) n bonded to a compound of formula (I), wherein n is 1-10, and wherein "aryl" is as defined above. Alternatively, an alkyl group may be bonded to a compound of formula (I) via a diradical aryl bridge (e.g., phenyl), wherein "alkyl" is as defined above. In some embodiments, the term "aralkyl" refers to a phenyl-alkyl group, wherein the phenyl group is bonded to a compound of formula (I).

[0095] As used herein, the term "heteroaryl" refers to a monovalent aromatic group having 1 to 12 carbon atoms, which has one or more oxygen, nitrogen and sulfur heteroatoms in the ring. In some embodiments, there are 1 to 4 oxygen, nitrogen and / or sulfur heteroatoms in the ring. In some embodiments, there are 1 to 3 oxygen, nitrogen and / or sulfur heteroatoms in the ring. In some embodiments, there are 2 oxygen and / or nitrogen heteroatoms in the ring. In some embodiments, there is 1 oxygen or nitrogen heteroatom in the ring. Nitrogen and sulfur heteroatoms can be optionally oxidized. Such heteroaryl groups can have a single ring (e.g., pyridyl or furyl) or multiple condensed rings, provided that the point of attachment is through heteroaryl ring atoms.

[0096] In some embodiments, heteroaryl is selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, pyrrolyl, indolyl, quinolyl, isoquinolyl, quinazolinyl, quinoxalinyl, furyl, thienyl, furyl (furyl), pyrrolyl, imidazolyl, oxazolyl, isoxazolyl, isothiazolyl, pyrazolyl, benzofuranyl and benzothienyl. The heteroaryl ring can be unsubstituted or substituted. In some embodiments, heteroaryl is selected from pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl and pyrrolyl. In some embodiments, heteroaryl is pyridyl.

[0097] As used herein, the term "heterocyclyl" refers to a fully saturated or unsaturated monocyclic group having one or more oxygen, sulfur, or nitrogen heteroatoms in the ring. In some embodiments, the heterocyclyl has 1 to 3 heteroatoms in the ring. In some embodiments, the heterocyclyl has 1 to 3 oxygen and / or nitrogen heteroatoms in the ring. In some embodiments, the heterocyclyl has 1 to 3 oxygen heteroatoms in the ring. The nitrogen and sulfur heteroatoms may be optionally oxidized, and the nitrogen heteroatom may be optionally quaternized. The heterocyclyl may be unsubstituted or substituted.

[0098] Exemplary monocyclic heterocyclyls include, but are not limited to, pyrrolidinyl, pyrrolyl, pyrazolyl, oxiranyl, oxetanyl, pyrazolinyl, imidazolyl, imidazolinyl, imidazolidinyl, oxazolyl, oxazolidinyl, isoxazolinyl, isoxazolyl, thiazolyl, thiadiazolyl, thiazolidinyl, isothiazolyl, isothiazolidinyl, furanyl, tetrahydrofuranyl, thienyl, oxadiazolyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopyrrolidinyl, 2-oxoazepinyl, azepinyl, 4-piperidonyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, tetrahydropyranyl, morpholinyl, thiomorpholinyl, thiomorpholinyl sulfoxide, thiomorpholinyl sulfone, 1,3-dioxolane and tetrahydro-1,1-dioxothiphenyl, triazolyl and triazinyl.

[0099] In some embodiments, the heterocyclyl group is selected from the group consisting of oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, and 1,3-dioxolane. In some embodiments, the heterocyclyl group is 1,3-dioxolane.

[0100] Where appropriate, all embodiments include all enantiomers, tautomers and geometric isomers of formula (I) compounds. Those of ordinary skill in the art will identify compounds with optical properties (one or more chiral carbon atoms) or tautomeric characteristics. Corresponding enantiomers and / or tautomers can be separated / prepared by methods known in the art. Some formula (I) compounds can also exist in stereoisomer and / or geometric isomer form, for example, they can have one or more asymmetric and / or geometric centers, therefore can exist in two or more stereoisomers and / or geometric forms. Where appropriate, all embodiments include all independent stereoisomers and geometric isomers and mixtures thereof using those compounds. The terms used in the claims encompass these forms.

[0101] Suitable salts of compounds of formula (I) include suitable acid addition salts or base salts thereof. Such salts and solvates thereof are known in the art. Suitable acid addition salts include carboxylates (e.g., formate, acetate, trifluoroacetate, propionate, isobutyrate, enanthate, decanoate, caprate, caprylate, stearate, acrylate, caproate, propiolate, ascorbate, citrate, glucuronate, glutamate, glycolate, α-hydroxybutyrate, lactate, tartrate, phenylacetate, mandelate, phenylpropionate, phenylbutyrate, benzoate, chlorobenzoate, methylbenzoate, hydroxybenzoate, methoxybenzoate, dinitrobenzoate, o-acetoxybenzoate, salicylate, nicotinate, isonicotinate, or 1,5-naphthalene disulfonate), or a sulfate, pyrosulfate, bisulfate, sulfite, bisulfite, phosphate, monohydrogenphosphate, dihydrogenphosphate, metaphosphate, pyrophosphate or nitrate.

[0102] In some embodiments, the one or more sensates further comprise a cooling agent selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino)acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, isopulegol, 3-menthoxypropane-1,2-diol, and menthyl succinate.

[0103] In some embodiments, the cooling agent is selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino) acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, 3-menthoxypropane-1,2-diol, and menthyl succinate.

[0104] In some embodiments, the cooling agent is selected from the group consisting of:

[0105]

[0106] The above chemical formulas are also shown in Appendix 1 together with the trade names and chemical names.

[0107] In some embodiments, the cooling agent is WS-23, N,2-3-trimethyl-2-propan-2-ylbutanamide.

[0108] In some embodiments, the cooling agent is selected from the group consisting of: (1S,2R,5S)-N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-[[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, (1R,2S,5R)-N-(4-methoxyphenyl-p-menthanylcarboxamide, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthanylcarboxamide, (-)-menthone 1,2-glycerol ketal, (-)-menthyl lactate, (-)-isopulegol, 3-((-)-menthoxy)propane-1,2-diol, and (-)-menthyl succinate. These compounds are shown in Appendix 1.

[0109] In some embodiments, the cooling agent is selected from the group consisting of: (1S,2R,5S)-N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-[[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, (1R,2S,5R)-N-(4-methoxyphenyl-p-menthanylcarboxamide, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthanylcarboxamide, (-)-menthone 1,2-glycerol ketal, (-)-menthyl lactate, 3-((-)-menthoxy)propane-1,2-diol, and (-)-menthyl succinate.

[0110] In some embodiments, the cooling agent is selected from the group consisting of: (1S,2R,5S)-N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-[[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, (1R,2S,5R)-N-(4-methoxyphenyl-p-menthanylcarboxamide, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthanylcarboxamide, (-)-menthone 1,2-glycerol ketal, (-)-menthyl lactate, (-)-isopulegol, and 3-((-)-menthoxy)propane-1,2-diol.

[0111] In some embodiments, the cooling agent is selected from the group consisting of: (1S,2R,5S)-N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-[[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide, (-)-menthone 1,2-glycerol ketal, (-)-menthyl lactate, (-)-isopulegol, and 3-((-)-menthoxy)propane-1,2-diol.

[0112] In some embodiments, the cooling agent is selected from the group consisting of: (1S,2R,5S)-N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-[[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide, (-)-menthone 1,2-glycerol ketal, (-)-menthyl lactate, and 3-((-)-menthoxy)propane-1,2-diol.

[0113] In some embodiments, the cooling agent is (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide. In another embodiment, the cooling agent is (1S,2R,5S)-N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide.

[0114] As described above, all embodiments include all enantiomers and tautomers of the compounds, where appropriate. All embodiments include the use of all individual stereoisomers and geometric isomers of those compounds, and mixtures thereof, where appropriate. The terms used in the claims encompass these forms.

[0115] In some embodiments, the one or more sensates consist of a cooling agent and a warming agent. In some embodiments, the one or more sensates consist of a cooling agent and a tingling agent. In some embodiments, the one or more sensates consist of a cooling agent, a warming agent, and a tingling agent.

[0116] As described above, the concentration range of about 0.001 to about 10% by weight relates to the total amount of sensates (e.g., warming or tingling agents) and, optionally, cooling agents in the consumable. For example, the consumable may contain about 0.001 to about 10% by weight of one or more sensates, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent is selected from the group consisting of vanilloids, sanshool, piperine, cinnamylphenylpropyl compounds, ethyl esters, and combinations thereof, or an extract from at least one of: ginger oil, black pepper, long pepper, Sichuan peppercorns, red pepper, or Uzazi, and wherein the one or more sensates optionally further comprise a cooling agent. Preferably, the warming or tingling agent comprises a vanilloid, such as 3-phenylpropyl homovanillate. Preferably, the cooling agent is selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino) acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, isopulegol, 3-menthoxypropane-1,2-diol and menthyl succinate.

[0117] In some embodiments, one or more sensates are present in the consumable in an amount from about 0.001% to about 5% by weight, wherein at least one sensate is a warming or tingling agent and the warming or tingling agent comprises a vanillin, and wherein the one or more sensates optionally further comprise a cooling agent selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino)acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, isopulegol, 3-menthoxypropane-1,2-diol, and menthyl succinate.

[0118] In some embodiments, one or more sensates are present in the consumable in an amount from about 0.001% to about 2.5% by weight, wherein at least one sensate is a warming or tingling agent and the warming or tingling agent comprises a vanillin, and wherein the one or more sensates optionally further comprise a cooling agent selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino)acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, isopulegol, 3-menthoxypropane-1,2-diol, and menthyl succinate.

[0119] In some embodiments, one or more sensates are present in the consumable in an amount from about 0.001% to about 1% by weight, wherein at least one sensate is a warming or tingling agent and the warming or tingling agent comprises a vanillin, and wherein the one or more sensates optionally further comprise a cooling agent selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino)acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, isopulegol, 3-menthoxypropane-1,2-diol, and menthyl succinate.

[0120] As described above, the warming or tingling agent can be present in a concentration of about 0.0001% to about 5% by weight, based on the total weight of the aerosolizable formulation, and this range can be combined with the above concentrations, including the total amount of sensate present. Preferably, the warming or tingling agent is present in a concentration of about 0.0001% to about 3% by weight, more preferably about 0.0001% to about 2.5% by weight, based on the total weight of the aerosolizable formulation.

[0121] In some embodiments, one or more sensates and their concentrations are selected based on their solubility in the emulsifier compound (iii). For example, the consumable may include an amount of one or more sensates in the emulsifier compound (iii), wherein the emulsifier compound (iii) is present in an amount of 50% or greater by weight of the consumable, such as 60% or greater by weight of the consumable, preferably 70% or greater by weight. Compound (iii) is as defined below.

[0122] In some embodiments, the emulsifier compound (iii) comprises triacetin, and the one or more sensates and their concentrations are selected based on their solubility in triacetin. For example, the consumable may comprise an amount of one or more sensates in triacetin, wherein the triacetin is present at 50% or greater by weight of the consumable, such as 60% or greater by weight of the consumable, and preferably 70% or greater by weight of the consumable. However, as will be apparent from the preceding paragraph, these concentrations apply not only to triacetin as compound (iii), but also to other emulsifiers defined in the appended claims and herein. In particularly preferred embodiments, the emulsifier compound (iii) is present at 80% or greater by weight of the consumable.

[0123] Thus, the present disclosure provides a consumable for an aerosolizable formulation, wherein the consumable comprises:

[0124] (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or the tingling agent is present in a concentration of at least about 0.0001% to about 5% by weight, based on the total weight of the consumable;

[0125] (ii) sweeteners; and

[0126] (iii) at least one compound which is an emulsifier and is C4 to C 38 Hydrocarbon esters, C4 to C 38 At least one of the hydrocarbon polyols or polyoxyalkylene fatty acid esters is present in 50% by weight or greater of the consumable.

[0127] In some embodiments, the consumable comprises:

[0128] (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or the tingling agent is present in a concentration of at least about 0.0001% to about 3% by weight, based on the total weight of the consumable;

[0129] (ii) sweeteners; and

[0130] (iii) at least one compound which is an emulsifier and is C4 to C 38 Hydrocarbon esters, C4 to C 38 At least one of the hydrocarbon polyols or polyoxyalkylene fatty acid esters is present in 60% by weight or greater of the consumable.

[0131] In some embodiments, the consumable comprises:

[0132] (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or the tingling agent is present in a concentration of at least about 0.0001% to about 2.5% by weight, based on the total weight of the consumable;

[0133] (ii) sweeteners; and

[0134] (iii) at least one compound which is an emulsifier and is C4 to C 38 Hydrocarbon esters, C4 to C 38 At least one of the hydrocarbon polyols or polyoxyalkylene fatty acid esters is present in 70% by weight or greater of the consumable.

[0135] In some embodiments, the consumable comprises:

[0136] (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or the tingling agent is present in a concentration of at least about 0.0001% to about 1% by weight, based on the total weight of the consumable;

[0137] (ii) sweeteners; and

[0138] (iii) at least one compound which is an emulsifier and is C4 to C 38 Hydrocarbon esters, C4 to C 38 At least one of the hydrocarbon polyols or polyoxyalkylene fatty acid esters is present in 80% by weight or greater of the consumable.

[0139] In each of these embodiments, the warming or tingling agent, sweetener and / or emulsifier compound is as defined herein. For example, at least one compound (iii) may be selected from C4 to C 16 Glycerides, C4 to C 16 Lactone, C8 to C 38 Hydrocarbyl maleate, C8 to C 38 Hydrocarbyl fumarate, C4 to C 38 Hydrocarbon polyols, and polyoxyethylene fatty acid esters; the sweetener may be a compound combining T1R2 and / or T1R3, or a compound selected from the following: oxadiazine sweetener, aspartame sweetener, sulfamate, calcium cyclamate, sugar alcohol, naturally occurring sweetener, saccharin, sucralose, gluconic acid and mixtures thereof; and the warming agent or tingling agent is selected from vanillin, sanshool, piperine, allyl isothiocyanate, cinnamyl phenylpropyl compound, ethyl ester and combinations thereof.

[0140] sweeteners

[0141] The consumables of the present disclosure include sweeteners. The term "sweetener" refers to a substance that is used to make food or beverage taste sweeter, which is used instead of sugar (sucrose), i.e., a sugar substitute. Sweeteners are easily identified in the art, and the term will be well understood by those of ordinary skill in the art. Sweeteners can be any sweetener or a combination of sweeteners, in natural or artificial form, or in a combination of natural and artificial sweeteners. Examples of natural sweeteners include fructose, glucose, maltose, mannose, galactose, lactose, stevia, etc. Examples of artificial sweeteners include sucralose, isomaltulose, maltodextrin, saccharin, aspartame, acesulfame K, neotame, etc.

[0142] Sweeteners can be defined as compounds that bind to T1R2 and / or T1R3. Those skilled in the art will understand that the phrase "binds to T1R2 and / or T1R3" means that the compound binds to the T1R2 receptor and / or the T1R3 receptor. T1R2 is also known as "taste receptor type 1, member 2," which is a human protein encoded by the TAS1R2 gene. Similarly, T1R3 is also known as "taste receptor type 1, member 3," which is a human protein encoded by the TAS1R3 gene. Sweet taste receptors in the human body are primarily formed as dimers of T1R2 and T1R3. However, natural sweeteners are understood to interact with the orthosteric binding pocket of T1R2 or T1R3.

[0143] The binding of sweet substances to sweet taste receptors activates one or more trimeric G proteins and produces second messengers in taste cells. Both cyclic AMP and calcium can act as second messengers. Sweeteners and one or more receptors involve several molecular interactions (e.g., van der Waals forces, electrostatics, hydrogen bonds, hydrophobicity, etc.) and physicochemical complementarity between one or more receptors and the sweetener. Protein structure files (one or more receptors) can be retrieved from the protein database and have been described using x-ray diffraction. Details are as follows:

[0144] T1R2 / T1R3:PDB:5X2P, https: / / www.rcsb.org / structure / 5X2P ,DOI:10.2210 / pdb5X2P / pdb

[0145] The active site pocket of the protein molecule is the site where the sweetener binds to the protein. A skilled artisan will understand how to determine whether a compound binds to the active site pocket of T1R2 and / or T1R3. These experiments can, for example, involve using a calcium fluorescence imaging assay based on HEK (human embryonic kidney 293) cells, as described and employed in Winnig et al., BMC Structural Biology 2007, 7:66, for neohesperidin dihydrochalcone.

[0146] In some embodiments, the sweetener can be selected from any suitable compound that binds to T1R2 and / or T1R3.

[0147] In some embodiments, the sweetener is selected from oxathiazine sweetener, aspartame sweetener, sulfamate, cyclamates (such as sodium or calcium), sugar alcohol, naturally occurring sweetener, saccharin, sucralose, gluconic acid and mixtures thereof. Sugar alcohol can include erythritol, arabitol, ribitol, isomalt, maltitol, galactitol, iditol, mannitol, xylitol, lactitol, sorbitol or a combination thereof. Technicians will understand that when sugar alcohol is included in the consumable, it can be used as a sweetener or an emulsifier. In some embodiments, (ii) is different from (iii). Erythritol is, for example, a C4 to C50 having a boiling point of at least 200° C. and used as an emulsifier. 18 Hydrocarbon polyols. When the emulsifier is sugar alcohol (i.e. 18 In some embodiments, additional sweeteners may be added to the consumable.

[0148] In some embodiments, the sweetener is selected from acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, calcium cyclamate, erythritol, xylitol, maltitol, mannitol, sorbitol, isomalt, tagatose, xylose, glycyrrhizin, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof.

[0149] In some embodiments, the sweetener comprises at least one selected from the group consisting of aspartame, stevioside, monk fruit extract, glycyrrhizin, perilla sugar, naringin dihydrochalcone, neohesperidin dihydrochalcone, mogroside V, rubusoside, Rubus officinalis extract, rebaudioside A, saccharin, sucralose, and sodium cyclamate. In some embodiments, the sweetener comprises at least one selected from the group consisting of aspartame, stevioside, saccharin, sucralose, and sodium cyclamate. Preferably, the sweetener comprises at least one selected from the group consisting of acesulfame-K, aspartame, neotame, saccharin, sucralose, and sodium cyclamate. More preferably, the sweetener is neotame or aspartame, such as neotame.

[0150] Those skilled in the art will appreciate that any of the above sweeteners can be used in combination to provide a "sweetener" in a defined consumable. In this regard, blending of sweeteners is well known in the art. For example, it can advantageously produce a synergistic sweetness effect, an improved taste profile, or an improved temporal profile. For example, aspartame is known to have a synergistic effect with acesulfame K, saccharin, and cyclamate. Sucralose has a moderate synergistic effect with other nutritive and non-nutritive sweeteners.

[0151] The absolute concentration of the sweetener is not critical to the present disclosure. In some embodiments, the sweetener and its concentration are selected based on its solubility in the emulsifier compound (iii). In some embodiments, the emulsifier compound (iii) comprises triacetin, and the sweetener and its concentration are selected based on its solubility in triacetin.

[0152] In some embodiments, the concentration of the sweetener can be defined by the concentration of one or more sensates, specifically by the weight ratio of the sensate to the sweetener. As described above, among the one or more sensates, at least one sensate is a warming agent or a tingling agent. Without wishing to be bound by theory, it is believed that the level of the sweetener can depend on the level of the one or more sensates because the sweetener can balance any irritation or aftertaste caused by the warming agent / tingling agent. In some embodiments, the weight ratio of the one or more sensates to the sweetener is greater than about 1:1 to about 3:1, such as greater than about 1:1 to about 2:1, preferably wherein the weight ratio of the one or more sensates to the sweetener is about 2:1.

[0153] In some embodiments, the weight ratio of one or more sensates to the sweetener can be adjusted to account for the potency of the sweetener. Sweet potency is defined as the number of times a sweetener is sweeter than sucrose. Sucrose can be assigned a value of 1 (for a 10% sucrose solution; see, e.g., Godshall MA., Sugar J. 2007; 69: 12-20), and a sweet potency greater than 1 is "more potent" than sucrose, while a sweet potency less than 1 is "less potent" than sucrose.

[0154] Neotame is the sweetener used in the examples herein. As reported in Godshall MA, 2007, neotame is 7000 to 13000 times sweeter than sucrose (a 10% sucrose solution by weight used as a reference), with an average value of 8000 times sweeter than sucrose. When the weight ratios defined above are defined using neotame as the sweetener, they can therefore be adjusted accordingly for sweeteners with greater or lesser potency. Sucralose (for example) is 600 times sweeter than sucrose and is 13.33 times less sweet than the average value of 8000 for neotame. Therefore, based on neotame, a weight ratio of one or more sensates to sweeteners greater than about 1:1 to about 3:1 becomes greater than about 1:13 to about 3:13 for sucralose. Similarly, a weight ratio of one or more sensates to sweeteners greater than about 1:1 to about 2:1 becomes greater than about 1:13 to about 2:13 for sucralose based on neotame.

[0155] For sweetness potency, the adjustment of the weight ratio from "greater than about 1:1 to about 3:1" can be represented by the following expression (1):

[0156] One or more sensates:sweetener = greater than about 1:(8000 / z) to about 3:(8000 / z)

[0157] Where z = sweetness potency of the sweetener relative to a 10 wt% sucrose solution

[0158] Expression (1)

[0159] For sweetness potency, the adjustment of the weight ratio from "greater than about 1:1 to about 2:1" can be represented by the following expression (2):

[0160] One or more sensates: sweetener = greater than about 1:(8000 / z) to about 2:(8000 / z)

[0161] Where z = sweetness potency of the sweetener relative to a 10 wt% sucrose solution

[0162] Expression (2)

[0163] One skilled in the art will understand that when the sweeteners are a combination, the average potency of the combination should be calculated based on the respective amounts of the sweeteners in the combination.

[0164] Sweeteners are defined as described above. Similarly, one or more sensates (including warming agents or tingling agents) are defined as described above. For example, the weight ratio of one or more sensates to sweeteners is greater than about 1:1 to about 3:1, wherein the warming agent or tingling agent comprises vanillin, and the sweetener is selected from acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, calcium cyclamate, erythritol, xylitol, maltitol, mannitol, sorbitol, isomalt, tagatose, xylose, glycyrrhizin, stevia, saccharin, sucralose, gluconic acid and mixtures thereof. The weight ratio can be adjusted according to the above expression (1).

[0165] In some embodiments, the weight ratio of one or more sensates to the sweetener is greater than 1:1 to about 3:1, wherein the warming agent or tingling agent is selected from the group consisting of vanillin, sanshool, piperine, cinnamylphenylpropyl compound, ethyl ester and combinations thereof, or the warming agent or tingling agent is an extract from at least one of: ginger oil, black pepper, long pepper, Sichuan pepper, red pepper or Uzazi, such as vanillin, and the sweetener is selected from acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, calcium cyclamate, erythritol, xylitol, maltitol, mannitol, sorbitol, isomalt, tagatose, xylose, glycyrrhizin, stevia, saccharin, sucralose, gluconic acid and mixtures thereof. The weight ratio can be adjusted according to the above expression (1).

[0166] In some embodiments, the weight ratio of the one or more sensates to the sweetener is greater than 1:1 to about 3:1, wherein the warming or tingling agent comprises vanillin, and wherein the sweetener is selected from the group consisting of acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to the above expression (1).

[0167] In some embodiments, the weight ratio of the one or more sensates to the sweetener is greater than 1:1 to about 3:1, wherein the warming or tingling agent comprises vanillin, and wherein the sweetener is selected from the group consisting of aspartame, neotame, stevia, saccharin, sucralose, and mixtures thereof. The weight ratio can be adjusted according to expression (1) above.

[0168] In some embodiments, the weight ratio of the one or more sensates to the sweetener is greater than 1:1 to about 3:1, wherein the warming or tingling agent comprises vanillin, and wherein the sweetener is selected from aspartame, neotame, and mixtures thereof. The weight ratio can be adjusted according to expression (1) above.

[0169] In some embodiments, the weight ratio of one or more sensates to the sweetener is greater than 1:1 to about 3:1, wherein the warming or tingling agent comprises a vanillin (e.g., 3-phenylpropyl homovanillate) and the sweetener is selected from aspartame, neotame, or a mixture thereof (e.g., neotame). The weight ratio can be adjusted according to the above expression (1).

[0170] In some embodiments, the weight ratio of one or more sensates to the sweetener is greater than 1:1 to about 2:1, wherein the warming or tingling agent comprises a vanillin (e.g., 3-phenylpropyl homovanillate) and the sweetener is selected from aspartame, neotame, or a mixture thereof (e.g., neotame). The weight ratio can be adjusted according to expression (2) above.

[0171] In some preferred embodiments, the weight ratio of one or more sensates to the sweetener is about 2:1, wherein the warming or tingling agent comprises a vanillin (e.g., 3-phenylpropyl homovanillate) and the sweetener is selected from aspartame, neotame, or a mixture thereof (e.g., neotame). The weight ratio can be adjusted according to the above expression (2).

[0172] As mentioned above, the concentration of sweetener is not critical for present disclosure.Preferably, alternatively according to the weight ratio defined above for one or more sensate balance sweeteners.But sweetener can be with about 0.0001 % by weight to about 5 % by weight, such as about 0.0001 % by weight to about 1 % by weight, preferably about 0.0001 % by weight to about 0.5 % by weight, more preferably about 0.0001 % by weight to about 0.25 % by weight amount exists.In particularly preferred embodiments, in the gross weight of consumables, sweetener can be with about 0.0001 to 0.1 % by weight amount exists.

[0173] In aerosolizable formulations, the sweetener may be present in an amount of about 0.0001 wt % to about 5 wt %, such as about 0.0001 wt % to about 3 wt %, preferably about 0.0001 wt % to about 2.5 wt %, more preferably about 0.0001 wt % to about 1 wt %.

[0174] In the same manner as the weight ratios of one or more sensates to sweeteners described above, skilled artisans will understand that these sweetener concentrations can be defined relative to neotame and adjusted based on the sweetness potency of the sweetener used in the consumable (if not neotame). As described above, sucralose has a sweetness potency that is about 13.3 times lower than neotame; therefore, for sucralose, a neotame concentration of about 0.0001% by weight to about 1% by weight would become about 0.0013% by weight to about 13.3% by weight based on the total weight of the aerosolizable formulation.

[0175] The following expressions can be defined:

[0176] About x wt % to about y wt % for neotame = about (8000 / z) x wt % to about (8000 / z) y wt % for alternative sweeteners

[0177] Where z = the sweetness potency of the alternative sweetener relative to a 10 wt% sucrose solution Expression (3)

[0178] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001% to about 10% by weight, based on the total weight of the consumable, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001% to about 5% by weight; a sweetener in an amount of about 0.0001% to about 5% by weight; and at least one compound (iii) (e.g., triacetin), wherein the weight ratio of the one or more sensates to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, warming agent / tingling agent, and sweetener are defined according to the above embodiments, and the emulsifier compound is defined according to the following embodiments. For example, the warming agent or tingling agent comprises vanillin (e.g., 3-phenylpropyl homovanillate), and wherein the sweetener is selected from acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratios can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0179] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001% to about 5% by weight, based on the total weight of the aerosolizable formulation, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001% to about 3% by weight; a sweetener in an amount of about 0.0001% to about 3% by weight; and at least one compound (iii), wherein the weight ratio of the one or more sensates to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, warming agent / tingling agent, and sweetener being defined according to the above embodiments, and the emulsifier compound being defined according to the following embodiments. For example, the warming agent or tingling agent comprises vanillin (e.g., 3-phenylpropyl homovanillate), and wherein the sweetener is selected from acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratios can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0180] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001% to about 5% by weight, based on the total weight of the consumable, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.001% to about 2.5% by weight; a sweetener in an amount of about 0.0001% to about 2.5% by weight; and at least one compound (iii), wherein the weight ratio of the one or more sensates to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, the warming agent / tingling agent, and the sweetener are defined according to the above embodiments, and the emulsifier compound is defined according to the following embodiments. For example, the warming agent or tingling agent comprises vanillin (e.g., 3-phenylpropyl homovanillate), and wherein the sweetener is selected from acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0181] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001% to about 2.5% by weight, based on the total weight of the aerosolizable formulation, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001% to about 2.5% by weight; a sweetener in an amount of about 0.0001% to about 2.5% by weight; and at least one compound (iii), wherein the weight ratio of the one or more sensates to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, warming agent / tingling agent, and sweetener are defined according to the above embodiments, and the emulsifier compound is defined according to the following embodiments. For example, the warming agent or tingling agent comprises vanillin (e.g., 3-phenylpropyl homovanillate), and wherein the sweetener is selected from acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0182] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001% to about 2.5% by weight, based on the total weight of the consumable, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001% to about 1% by weight; a sweetener in an amount of about 0.0001% to about 1% by weight; and at least one compound (iii), wherein the weight ratio of the one or more sensates to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, the warming agent / tingling agent, and the sweetener are defined according to the above embodiments, and the emulsifier compound is defined according to the following embodiments. For example, the warming agent or tingling agent comprises vanillin (e.g., 3-phenylpropyl homovanillate), and wherein the sweetener is selected from acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0183] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001% to about 1% by weight, based on the total weight of the consumable, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001% to about 1% by weight; a sweetener in an amount of about 0.0001% to about 1% by weight; and at least one compound (iii), wherein the weight ratio of the one or more sensates to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, the warming agent / tingling agent, and the sweetener are defined according to the above embodiments, and the emulsifier compound is defined according to the following embodiments. For example, the warming agent or tingling agent comprises vanillin (e.g., 3-phenylpropyl homovanillate), and wherein the sweetener is selected from acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0184] Compound (iii)

[0185] The consumable product comprises at least one compound (iii) which is an emulsifier. It has been unexpectedly discovered that the compound modulates the mouthfeel of an aerosol produced by an aerosolizable formulation or an aerosol generating system, wherein the mouthfeel is modulated to replicate one or more sensations of smoking a combustible tobacco product. For example, the modulated sensation may be taste, mouthfeel, and / or smoking experience, and as shown in the Examples herein, such sensations include impact, stimulation, aerosol body sensation, and / or mouth coating.

[0186] The term "emulsifier" is defined above and according to the commonly known meaning of the term. A skilled person will be able to readily determine whether a compound is an emulsifier since it is a well-known class of compounds. Examples of suitable compounds are also listed below.

[0187] In addition to being an emulsifier, at least one compound (iii) may have a boiling point of at least about 200° C. at atmospheric pressure. The term "atmospheric pressure" refers to 101325 Pa, equivalent to 760 mmHg. Boiling is the formation of vapor bubbles below the surface of a liquid and occurs when the equilibrium vapor pressure of the compound is greater than or equal to the ambient pressure. The temperature at which boiling occurs is the boiling temperature or boiling point. The boiling points of individual compounds at atmospheric pressure are reported in the literature and will be readily identified by one of ordinary skill in the art. Examples of boiling points of suitable emulsifier compounds are also listed below.

[0188] In some embodiments, the boiling point of the emulsifier compound has a lower limit of about 200 ° C at atmospheric pressure. This meets the requirements that the consumable is suitable for use in aerosolizable formulations or aerosol generating systems, such as formulations for non-flammable aerosol supply devices. As described above, the humectant compound (iii) can be a contributing factor to the "satisfaction" (i.e., aerosol body sensation) and aerosol impact of the oral coating and / or oral cavity perceived after use, each of which is adjusted to replicate smoking, such as traditional cigarettes. Therefore, compound (iii) may be at least partially present in the aerosol generated by the aerosolizable formulation of the consumable comprising the present disclosure. The compound itself can be aerosolized, or it can be carried in the aerosol by other components, such as aerosol forming agent materials or carriers defined herein. The present disclosure is not limited in this respect.

[0189] In some embodiments, the humectant compound has a boiling point of at least about 250° C. at atmospheric pressure. In some embodiments, the humectant compound has a boiling point of at least about 280° C. In some embodiments, the humectant compound has a boiling point of at least about 300° C.

[0190] When defining boiling point, the upper limit of the boiling point of at least one compound (iii) is not limited. However, when the boiling point range has an upper limit, the upper limit is not applicable to polyoxyalkylene fatty acid esters. In some embodiments, the boiling point of at least one compound (iii) at atmospheric pressure is at least about 200 ° C to about 400 ° C. In some embodiments, the boiling point of at least one compound (iii) at atmospheric pressure is at least about 250 ° C to about 400 ° C. In some embodiments, the boiling point of at least one compound (iii) at atmospheric pressure is at least about 280 ° C to about 400 ° C. In some embodiments, the boiling point of at least one compound (iii) at atmospheric pressure is at least about 300 ° C to about 400 ° C.

[0191] In other embodiments, at least one compound (iii) has a boiling point at atmospheric pressure of at least about 200° C. to about 350° C. In some embodiments, at least one compound (iii) has a boiling point at atmospheric pressure of at least about 200° C. to about 325° C. In some embodiments, at least one compound (iii) has a boiling point at atmospheric pressure of at least about 200° C. to about 300° C.

[0192] The following table lists some boiling points of exemplary compounds; however, the present disclosure is not limited to the compounds listed.

[0193] Compound Boiling point at atmospheric pressure (℃) Triacetin 258 Diethyl maleate 226 butyl-caprolactone 213

[0194] In some embodiments, compound (iii) is not propylene glycol or glycerol.

[0195] In some embodiments, at least one compound (iii) is C4 to C 38 Hydrocarbon esters, C4 to C 38 Hydrocarbyl polyols, or polyoxyalkylene fatty acid esters. The term "hydrocarbyl" refers to a monovalent group formed by removing a hydrogen atom from a hydrocarbon, which may be an alkyl, alkenyl, alkynyl, aryl, or aralkyl group. The alkyl, alkenyl, alkynyl, aryl, or aralkyl group may be optionally substituted. In some embodiments, the hydrocarbon (alkyl, alkenyl, alkynyl, aryl, aralkyl group) may be unsubstituted.

[0196] As used herein for emulsifiers, the term "alkyl" includes saturated straight and branched chain alkyl groups, which may be substituted (single or multiple) or unsubstituted. In some embodiments, the alkyl group is C 4-38 In some embodiments, the alkyl group is C 8-38 In some embodiments, the alkyl group is C 12-34 alkyl.

[0197] In other embodiments, the alkyl group is C 4-18 In some embodiments, the alkyl group is C 4-16 In some embodiments, the alkyl group is C 4-12 alkyl.

[0198] In other embodiments, the alkyl group is C 5-18 In some embodiments, the alkyl group is C 6-18 In some embodiments, the alkyl group is C 6-16 alkyl.

[0199] As used herein for emulsifiers, the term "alkenyl" includes unsaturated straight and branched chain alkenyl groups, which may be substituted (single or multiple) or unsubstituted. In some embodiments, alkenyl is C 4-38 In some embodiments, alkenyl is C 8-38 In some embodiments, alkenyl is C 12-34 Alkenyl.

[0200] In other embodiments, alkenyl is C 4-18 In some embodiments, the alkyl group is C 4-16 In some embodiments, alkenyl is C 4-12 Alkenyl.

[0201] In other embodiments, alkenyl is C 5-18 In some embodiments, alkenyl is C 6-18 In some embodiments, alkenyl is C 6-16 Alkenyl.

[0202] As used herein for the emulsifier, the term "alkynyl" includes unsaturated straight and branched chain alkenyl groups, which may be substituted (single or multiple) or unsubstituted. In some embodiments, the alkyl group is C 4-38 In some embodiments, the alkynyl group is C 8-38 In some embodiments, the alkynyl group is C 12-34 Alkynyl.

[0203] In other embodiments, the alkynyl group is C 4-18 In some embodiments, the alkynyl group is C 4-16 In some embodiments, the alkynyl group is C 4-12 Alkynyl.

[0204] As used herein for emulsifiers, the term "aryl" refers to a C 6-18 Aryl, which may be substituted (single or multiple) or unsubstituted. In some embodiments, aryl is C 6-12 Typical examples include phenyl and naphthyl. In some embodiments, the aryl group is phenyl.

[0205] The term "aralkyl" is used as a combination of the terms alkyl and aryl as given above.

[0206] If the hydrocarbon is a branched structure having one or more substituents thereon, the substitution may be on the hydrocarbon backbone or on the side chain. Alternatively, the one or more substitutions may be on the hydrocarbon backbone and the side chain. Examples of suitable substitutions include hydroxyl and alkoxy.

[0207] Where appropriate, all embodiments include all enantiomers, tautomers and geometric isomers of emulsifier compound (iii). Those of ordinary skill in the art will identify compounds with optical properties (one or more chiral carbon atoms) or tautomeric characteristics. Corresponding enantiomers and / or tautomers can be separated / prepared by methods known in the art. Some emulsifier compounds (iii) can also exist in stereoisomer and / or geometric isomer form, for example, they can have one or more asymmetric and / or geometric centers, therefore can exist in two or more stereoisomers and / or geometric forms. Where appropriate, all embodiments include all independent stereoisomers and geometric isomers and mixtures thereof using those compounds. The terms used in the claims encompass these forms.

[0208] In some embodiments, C4 to C 38 Hydrocarbyl esters are C4 to C 38 Alkyl ester or alkenyl ester.

[0209] The term "ester" refers to a compound derived from an acid in which the hydrogen atom of at least one of the acidic hydroxyl groups (-OH) of the acid is replaced by an organic group (-R). 38 Hydrocarbyl esters will have the hydrogen of at least one acidic hydroxyl group replaced by an organic group (-R), provided that the sum of carbon atoms in the compound is 4 to 38. Suitable organic groups are known in the art. Therefore, the term "ester" includes partial esters, i.e. compounds that simultaneously include one or more-OH groups and one or more-OR groups.

[0210] In some embodiments, C4 to C 38 Hydrocarbyl esters are C4 to C 38 Hydrocarbon monoester or diester. In some embodiments, C4 to C 38 Hydrocarbon monoesters or diesters are C4 to C 38 Alkyl or alkenyl monoester or diester, preferably C8 to C 38 Alkyl or alkenyl monoesters or diesters. Examples include monoalkyl fumarate or dialkyl esters and monoalkyl maleate or dialkyl esters, and lactones as defined below. In some embodiments, C8 to C 38 Hydrocarbon monoester or diester is C 12 to C 34 Alkyl or alkenyl monoesters or diesters. Examples include mono- or dioctyl, mono- or didodecyl, and mono- or didodecyl fumarate, and mono- or dioctyl, mono- or didodecyl, and mono- or didodecyl maleate.

[0211] The term "ester" also includes glycerides, i.e., esters formed from glycerol and fatty acids. Thus, in some embodiments, C4 to C 38 Hydrocarbyl esters are glycerides. Glycerol has three hydroxyl functional groups that can be esterified with one, two, or three fatty acids to form monoglycerides, diglycerides, and triglycerides. The fatty acid alkyl groups of these structures are different because they can contain different carbon numbers, different degrees of unsaturation, and different olefin configurations and positions. However, they are connected to a chemical core structure (i.e., glycerol).

[0212] In some embodiments, C4 to C 38 The hydrocarbon ester is a monoglyceride, a diglyceride or a triglyceride, preferably a diglyceride or a triglyceride, such as a C4 to C 18 A diglyceride or triglyceride, exemplified by diacetin or triacetin. Particularly preferred embodiments are those in which the glyceride is a triglyceride, such as a C4 to C 16 Triglycerides are exemplified herein by triacetin.

[0213] Triacetin is an organic compound having the chemical formula shown in Appendix 1. It is classified as a triglyceride, i.e., a three-ester of glycerol, and is a common food additive, for example, as a solvent in flavorings and for its emulsifying or moisturizing properties. It is available from various commercial sources. In some embodiments, a consumable may include an amount of one or more sensates in triacetin, wherein the triacetin is present in an amount of 50% or greater by weight of the consumable, such as 60% or greater by weight of the consumable, and preferably 70% or greater by weight.

[0214] In some embodiments, C4 to C 38 Hydrocarbyl esters are lactones, i.e., cyclic carboxylic acid esters containing a 1-oxacycloalkane-2-one structure (-C(=O)-O=). Lactones are known in the art as condensation products; they are formed by the intramolecular esterification of the corresponding hydroxycarboxylic acids, which occurs spontaneously when the ring formed is a five-membered or six-membered ring. In some embodiments, C4 to C 38 Hydrocarbyl esters are C5 to C 38 Lactone, preferably C6 to C 38 lactone, more preferably C6 to C 18 Lactone.

[0215] In some embodiments, the lactone is a compound of formula (II):

[0216]

[0217] wherein R1, R2 and L are each independently an alkyl or alkenyl group, or wherein R1 and R2 are each independently an alkyl or alkenyl group, and L is a carbon-carbon bond between R1 and R2, wherein the alkyl or alkenyl group is optionally substituted with an alkyl or alkenyl group, with the proviso that the sum of carbon atoms in the compound of formula (II) is 4 to 38, preferably 5 to 38 and more preferably 6 to 38.

[0218] In some embodiments, R1 is unsubstituted alkyl or alkenyl, and R2 is optionally substituted alkyl or alkenyl.

[0219] In some embodiments, R1 is unsubstituted alkyl or alkenyl, and R2 is substituted alkyl or alkenyl.

[0220] In some embodiments, the compound of formula (I) is selected from δ-decalactone, γ-decalactone, δ-dodecalactone, γ-dodecalactone, γ-heptadecalactone, ω-6-hexadecene lactone, δ-caprolactone, γ-caprolactone, δ-nonalactone, γ-nonalactone, δ-octalactone, γ-octalactone, ω-pentadecalactone, δ-undecalactone and γ-undecalactone.

[0221] In some embodiments, C4 to C 38 The hydrocarbon polyol has at least three hydroxyl groups. 38The hydrocarbon polyol is a C4 to C 38 Alkyl or alkenyl polyols, preferably C4 to C 38 In some embodiments, C4 to C 38 The hydrocarbon polyol is a C4 to C 18 Alkyl polyols, preferably C4 to C 16 Alkyl polyols.

[0222] In some embodiments, C4 to C 38 Hydrocarbyl polyols are C4 to C 38 Alkyl or alkenyl polyols, preferably C4 to C5 having up to six hydroxyl groups 38 In some embodiments, C4 to C 38 Hydrocarbyl polyols are C4 to C 18 Alkyl polyols, preferably C4 to C 16 Alkyl polyols.

[0223] In some embodiments, C4 to C 38 The hydrocarbon polyol has three to six hydroxyl groups. 38 Hydrocarbyl polyols are C4 to C6 polyols having three to six hydroxyl groups. 38 Alkyl or alkenyl polyols, preferably C4 to C5 having three to six hydroxyl groups 38 In some embodiments, C4 to C 38 Hydrocarbyl polyols are C4 to C6 polyols having three to six hydroxyl groups. 18 Alkyl polyols, preferably C4 to C5 having three to six hydroxyl groups 16 Alkyl polyols.

[0224] In some embodiments, the polyoxyalkylene fatty acid ester is a polyoxyethylene fatty acid ester, a polyoxypropylene fatty acid ester, or a polyoxybutylene fatty acid ester. In some embodiments, the polyoxyalkylene fatty acid ester is a polyoxyethylene fatty acid ester, preferably a polyoxyethylene sorbitan fatty acid ester. Polyoxyethylene sorbitan fatty acid esters are also referred to as polysorbates in the art.

[0225] In some embodiments, at least one compound (iii) is selected from C4 to C 38 Alkyl or alkenyl esters, C4 to C 38 Alkyl or alkenyl polyols (the polyol optionally having at least three hydroxyl groups), and polyoxyalkylene fatty acid esters.

[0226] In some embodiments, at least one compound (iii) is selected from C4 to C 38Alkyl or alkenyl monoester or diester, C4 to C 18 Glycerides, C4 to C 38 Alkyl or alkenyl polyols (the polyol optionally having at least three hydroxyl groups), and polyoxyalkylene fatty acid esters.

[0227] In some embodiments, at least one compound (iii) is selected from C8 to C 38 Alkyl or alkenyl diesters, C4 to C 18 Glycerides, C4 to C 38 Lactone, C4 to C 38 Alkyl or alkenyl polyols (the polyol optionally having at least three hydroxyl groups), and polyoxyalkylene fatty acid esters.

[0228] In some embodiments, at least one compound (iii) is selected from C4 to C 38 Hydrocarbyl maleate or fumarate, preferably C8 to C 38 Alkyl maleate or fumarate, C4 to C 18 Glycerides, C5 to C 18 lactone (preferably represented by the compound of formula (II)), C4 to C 38 Hydrocarbyl (preferably alkyl) polyols (the polyol optionally having at least three hydroxyl groups), and polyoxyalkylene fatty acid esters.

[0229] In some embodiments, at least one compound (iii) is selected from C4 to C 38 Hydrocarbyl maleate or fumarate, preferably C8 to C 38 Alkyl maleate or fumarate, C4 to C 18 Glycerides, C5 to C 18 lactone (preferably represented by the compound of formula (II)), C4 to C 18 Hydrocarbyl (preferably alkyl) polyols (the polyol optionally having at least three hydroxyl groups), and polyoxyethylene fatty acid esters.

[0230] In some embodiments, at least one compound (iii) is selected from C8 to C 38 Hydrocarbyl maleate or fumarate, preferably C 12 to C 34 Alkyl maleate or fumarate, C4 to C 18 Glycerides, C6 to C 16 lactone (preferably represented by the compound of formula (II)), C4 to C 18 Hydrocarbyl (preferably alkyl) polyols (the polyol optionally having at least three hydroxyl groups), and polyoxyethylene sorbitan fatty acid esters.

[0231] In some embodiments, at least one compound (iii) is selected from C4 to C 18Glycerides, C5 to C 16 lactone (preferably represented by the compound of formula (II)), C4 to C 18 Hydrocarbyl (preferably alkyl) polyols (the polyol optionally having at least three hydroxyl groups), and polyoxyethylene sorbitan fatty acid esters.

[0232] In some embodiments, at least one compound (iii) is selected from C4 to C 16 Glycerides, C6 to C 16 lactone (preferably represented by the compound of formula (II)), C4 to C 18 Hydrocarbyl groups (preferably alkyl groups), polyols (the polyols optionally have at least three hydroxyl groups), and polyoxyethylene sorbitan fatty acid esters.

[0233] In some embodiments, at least one compound (iii) is selected from C4 to C 12 Glycerides, C6 to C 16 lactone (preferably represented by the compound of formula (II)), C4 to C 18 Alkyl polyol (the polyol optionally having at least three hydroxyl groups), and polyoxyethylene sorbitan fatty acid ester.

[0234] Thus, the present disclosure provides a consumable for an aerosolizable formulation, wherein the consumable comprises:

[0235] (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or the tingling agent is present in a concentration of at least about 0.0001% to about 5% by weight, based on the total weight of the consumable;

[0236] (ii) sweeteners; and

[0237] (iii) at least one compound which is an emulsifier and is selected from C4 to C 38 Alkyl or alkenyl monoester or diester, C4 to C 18 Glycerides, C4 to C 38 An alkyl or alkenyl polyol (the polyol optionally having at least three hydroxyl groups), and a polyoxyalkylene fatty acid ester, at least one compound being present in 50% by weight or greater of the consumable.

[0238] In some embodiments, the consumable comprises:

[0239] (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or the tingling agent is present in a concentration of at least about 0.0001% to about 3% by weight, based on the total weight of the consumable;

[0240] (ii) sweeteners; and

[0241] (iii) at least one compound which is an emulsifier and is selected from C4 to C 38 Hydrocarbyl maleate or fumarate (preferably C4 to C 38 Alkyl maleate or fumarate), C4 to C 18 Glycerides, C4 to C 38 lactone (preferably represented by the compound of formula (II)), C4 to C 38 A hydrocarbyl (preferably alkyl) polyol (the polyol optionally having at least three hydroxyl groups), and a polyoxyalkylene fatty acid ester, at least one compound being present in 60% by weight or greater of the consumable.

[0242] In some embodiments, the consumable comprises:

[0243] (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or the tingling agent is present in a concentration of at least about 0.0001% to about 2.5% by weight, based on the total weight of the consumable;

[0244] (ii) sweeteners; and

[0245] (iii) at least one compound which is an emulsifier and is selected from C4 to C 38 Hydrocarbyl maleate or fumarate (preferably C8 to C 38 Alkyl maleate or fumarate), C4 to C 16 Glycerides, C5 to C 18 lactone (preferably represented by the compound of formula (II)), C4 to C 18 A hydrocarbyl (preferably alkyl) polyol (the polyol optionally having at least three hydroxyl groups), and a polyoxyethylene sorbitan fatty acid ester, at least one compound being present in 70% by weight or greater of the consumable.

[0246] In some embodiments, the consumable comprises:

[0247] (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or the tingling agent is present in a concentration of at least about 0.0001% to about 1% by weight, based on the total weight of the consumable;

[0248] (ii) sweeteners; and

[0249] (iii) at least one compound which is an emulsifier and is selected from C4 to C 12 Glycerides, C6 to C 16 lactone (preferably represented by the compound of formula (II)), C4 to C 18A hydrocarbyl (preferably alkyl) polyol (the polyol optionally having at least three hydroxyl groups), and a polyoxyethylene sorbitan fatty acid ester, at least one compound being present in 80% by weight or greater of the consumable.

[0250] Additional ingredients

[0251] In addition to the above-mentioned sensory agents, sweeteners and emulsifiers (such as triacetin), consumables may include one or more other ingredients. The concentration of one or more other ingredients is not limited, and in some embodiments may be about 0.001% by weight to about 10% by weight of the consumables. In some embodiments, the consumables further include one or more compounds selected from the group consisting of 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furfurylthiol, sotolon, 2,4-lutidine, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanol, β-damascone, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide, 3-methylbutanal, acetic acid, 2-methylbutyric acid, 3-methylbutyric acid, 3-methylvaleric acid, butyric acid, β-damascone, β-ionone, α-ionone, α-ionol, β-cyclocitral, safranal, Maltol, ethyl maltol, 2-methoxyphenol, 4-methyl-2-methoxyphenol, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, phenylacetic acid, methylcyclopentenolone, ethylmethylcyclopentenolone, coronol, mesifurane, maplefuranone, benzaldehyde, 4-propyl-2-methoxyphenol, 4-allyl-2,6-dimethoxyphenol, 3-methyl-2,4-nonanedione, 5,6,7-trimethylocta-2,5-dien-4-one, or a combination thereof. The above concentration range applies to the inclusion of one or more of these compounds.

[0252] In some embodiments, the one or more compounds include at least one compound selected from 4-propylphenol, 4-ethyl-2-methoxyphenol, 3-ethylphenol, 2,6-dimethoxyphenol, sotolon, and / or 2,4-lutidine.

[0253] In some embodiments, the one or more compounds are selected from the group consisting of: 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furfurylthiol, sotolon, 2,4-lutidine, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanol, β-damascone, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide, 3-methylbutanal, or a combination thereof. In a preferred embodiment, the consumable comprises four or five compounds selected from the group consisting of: 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furfurylthiol, sotolon, 2,4-lutidine, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanol, β-damascone, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide, and 3-methylbutanal.

[0254] Particularly preferred are:

[0255] (i) 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furfurylthiolsotolan;

[0256] (ii) 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, sotolon;

[0257] (iii) 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2,4-dimethylpyridine, 2-ethyl-3,5-dimethylpyrazine;

[0258] (iv) Sotolon, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanol;

[0259] (v) 2-furfurylthiol, 2,4-lutidine, 3-ethylphenol, β-damascena;

[0260] (vi) 2-ethyl-3,5-dimethylpyrazine, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide;

[0261] (vii) 2-furfurylthiol, sotolon, 2,4-lutidine, 3-ethylphenol, dimethyl trisulfide; or

[0262] (viii) 2-furfurylthiol, 2,4-dimethylpyridine, 2-ethyl-3,5-dimethylpyrazine, furanol, and 3-methylbutanal.

[0263] In some embodiments, at least one compound is selected from Compounds A, B, C, D, E, and combinations thereof. Each of Compounds A, B, C, D, and E is defined below.

[0264] Compound A

[0265] In some embodiments, A is at least one compound selected from the group consisting of acetic acid, 2-methylbutanoic acid, 3-methylbutanoic acid, 3-methylvaleric acid, and butanoic acid. In some embodiments, compound A is 3-methylbutanoic acid, also known as isovaleric acid. In some embodiments, compound A is acetic acid. In some embodiments, compound A is 3-methylpentanoic acid, also known as 3-methylvaleric acid. In some embodiments, compound A is 2-methylbutanoic acid. In some embodiments, compound A is butyric acid, also known as butanoic acid. In some embodiments, A is at least acetic acid and 2-methylbutanoic acid. Preferably, A is at least one compound selected from the group consisting of acetic acid, 3-methylbutanoic acid, and 3-methylvaleric acid.

[0266] Compound B

[0267] In some embodiments, B is at least one compound selected from the group consisting of β-damascone, β-damascenone, β-ionone, α-ionone, α-ionol, β-cyclocitral, and safranal. In some embodiments, B is at least two compounds selected from the group consisting of β-damascone, β-damascenone, and β-ionone, α-ionone, α-ionol, β-cyclocitral, and safranal. In some embodiments, B is at least β-damascone, β-damascenone, and β-ionone. Preferably, B is at least one compound selected from the group consisting of β-damascone, β-damascenone, and β-ionone.

[0268] Compound C

[0269] In some embodiments, C is at least one compound selected from the group consisting of maltol, ethyl maltol, and sotolon. In some embodiments, C is at least two compounds selected from the group consisting of maltol, ethyl maltol, and sotolon. Preferably, C is at least one compound selected from the group consisting of maltol and sotolon.

[0270] Compound D

[0271] In some embodiments, D is at least one compound selected from the group consisting of 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-dimethoxyphenol, phenylacetic acid, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, methylcyclopentenolone, ethylmethylcyclopentenolone, crotonol, methyfuran, furanone, 4-propyl-2-methoxyphenol, benzaldehyde, and 4-allyl-2,6-dimethoxyphenol. Preferably, D is at least one compound selected from the group consisting of 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-dimethoxyphenol, and phenylacetic acid.

[0272] Compound E

[0273] In some embodiments, E is at least one compound selected from the group consisting of 3-methyl-2,4-nonanedione and 5,6,7-trimethylocta-2,5-dien-4-one. Preferably, E is 3-methyl-2,4-nonanedione.

[0274] In some embodiments, the consumable comprises three or more compounds selected from compounds A, B, C, D, and E, wherein each of A, B, C, D, and E is as defined herein. In some embodiments, the consumable comprises four or more compounds selected from compounds A, B, C, D, and E, wherein each of A, B, C, D, and E is as defined herein. In some embodiments, the consumable comprises at least compounds A, B, C, and D, wherein each of A, B, C, and D is as defined herein. In some embodiments, the consumable comprises a compound from each of compounds A, B, C, D, and E, wherein each of A, B, C, D, and E is as defined herein.

[0275] In some embodiments, when two or more different A compounds are present, they may be selected from two or more of the group consisting of acetic acid, 3-methylbutanoic acid, 3-methylpentanoic acid, 2-methylbutanoic acid, and butanoic acid. In some embodiments, when two or more different A compounds are present, they are at least butanoic acid and 3-methylbutanoic acid.

[0276] In addition to compounds A, B, C and D, the consumable of the present invention may also contain one or more of the following compounds belonging to component E: 3-methyl-2,4-nonanedione and 5,6,7-trimethylocta-2,5-dien-4-one.

[0277] When present, compounds A, C, and D may be present in the following weight ratios relative to compound B (total B components): A:B from 5 to 10:1; C:B from 5 to 10:1; and D:B from 10 to 15:1. In one embodiment, compounds A, C, and D may be present in the following weight ratios relative to compound B (total B compounds): A:B from 1 to 5:1; C:B from 1 to 5:1; and D:B from 5 to 10:1. In one embodiment, compounds A, C, and D may be present in the following weight ratios relative to compound B (total B compounds): A:B from 5 to 10:1; C:B from 15 to 25:1; and D:B from 5 to 10:1.

[0278] Aerosolizable formulation or aerosol generating system

[0279] In some embodiments, an aerosolizable formulation for an aerosol delivery system is provided, comprising a consumable as defined herein, a carrier, and optionally nicotine. In some embodiments, the formulation comprises a consumable as defined herein, a carrier, and nicotine. In some embodiments, the formulation comprises the consumable in an amount of at least about 1% by weight, such as at least about 5% by weight, and preferably at least about 10% by weight. The consumable may be present in the formulation in an amount of no more than about 25% by weight, such as no more than about 20% by weight, and preferably no more than about 15% by weight.

[0280] In some embodiments, the consumables may be present in the formulation in an amount of about 1 wt% to about 25 wt%, such as about 5 wt% to about 20 wt%, preferably about 10 wt% to about 15 wt%.

[0281] The aerosolizable formulation can be in various forms, including gel, liquid, or solid. In some preferred embodiments, the aerosolizable formulation is a liquid. In other preferred embodiments, the aerosolizable formulation is a gel. In some embodiments, the consumable is in liquid or gel form.

[0282] carrier

[0283] When the aerosolizable formulation is a liquid, the carrier of the formulation can be any suitable solvent so that the formulation can be evaporated for use. In some embodiments, the solvent is selected from glycerol, propylene glycol, water, and mixtures thereof. In some embodiments, the solvent is selected from glycerol, propylene glycol, and mixtures thereof. In some embodiments, the solvent is at least glycerol. In some embodiments, the solvent consists essentially of glycerol. In some embodiments, the solvent consists of glycerol. In some embodiments, the solvent is at least propylene glycol. In some embodiments, the solvent consists essentially of propylene glycol. In some embodiments, the solvent consists of propylene glycol. In some embodiments, the solvent is a mixture of at least propylene glycol and glycerol. In some embodiments, the solvent consists essentially of a mixture of propylene glycol and glycerol. In some embodiments, the solvent consists of a mixture of propylene glycol and glycerol.

[0284] The carrier of the formulation can be present in any suitable amount. In some embodiments, the carrier is present in an amount of about 50% by weight or greater, preferably about 70% by weight or greater, based on the total weight of the formulation. In some embodiments, the carrier is present in an amount of about 50 to about 99% by weight based on the total weight of the formulation, such as about 60 to about 98% by weight based on the formulation, and preferably about 70 to about 95% by weight based on the formulation.

[0285] In some embodiments, the formulation is a liquid and comprises from about 1% to about 25% by weight of the consumable, from about 50% to about 99% by weight of the carrier, and optionally nicotine, such as from about 5% to about 20% by weight of the consumable, from about 60% to about 98% by weight of the carrier, and optionally nicotine, preferably from about 10% to about 15% by weight of the consumable, from about 70% to about 95% by weight of the carrier, and optionally nicotine.

[0286] Nicotine

[0287] Nicotine can be provided in any suitable amount, depending on the desired dose when the formulation is aerosolized and inhaled by the user. In some embodiments, nicotine is present in an amount of no more than about 6% by weight, based on the total weight of the formulation. In some embodiments, nicotine is present in an amount of about 0.1 to about 6% by weight, based on the total weight of the formulation, such as about 0.5 to about 6% by weight, based on the total weight of the formulation, and preferably about 0.5 to about 5% by weight, based on the total weight of the formulation.

[0288] In some embodiments, the aerosolizable formulation is a liquid and may comprise from about 1% to about 25% by weight of a consumable, wherein the consumable is defined according to the embodiments above; from about 50% to about 99% by weight of a carrier; and from about 0.1% to about 6% by weight of nicotine.

[0289] In some embodiments, the aerosolizable formulation is a liquid and may comprise from about 5% to about 20% by weight of a consumable, wherein the consumable is defined according to the embodiments above; from about 60 to about 98% by weight of a carrier; and from about 0.5 to about 6% by weight of nicotine.

[0290] In some preferred embodiments, the aerosolizable formulation is a liquid and may comprise from about 10% to about 15% by weight of a consumable, wherein the consumable is defined according to the above embodiments; from about 70% to about 95% by weight of a carrier; and from about 0.5% to about 5% by weight of nicotine.

[0291] In some embodiments, the preparation may contain one or more acids other than nicotine (as an active agent). In some embodiments, the one or more acids may be one or more organic acids. In some embodiments, the one or more acids may be one or more organic acids selected from the group consisting of: benzoic acid, levulinic acid, malic acid, maleic acid, fumaric acid, citric acid, lactic acid, acetic acid, succinic acid, and mixtures thereof. When included in a preparation in combination with nicotine, the one or more acids may provide a preparation in which the nicotine is at least partially in a protonated (such as monoprotonated and / or diprotonated) form. In some preferred embodiments, the one or more acids include benzoic acid and / or levulinic acid. In some preferred embodiments, the one or more acids include benzoic acid.

[0292] Adhesives

[0293] In some embodiments, an aerosolizable formulation or an aerosol generating system is provided, comprising a consumable as defined herein, an aerosol former material, one or more binders and optionally a plant material. In a preferred embodiment, the binder consists of one or more gelling agents.

[0294] Suitably, the aerosolizable formulation or aerosol-generating system comprises from about 2% to about 80% by weight of one or more binders, for example from about 5%, 7%, 10%, 15%, 17%, 20% or 25% to about 70%, 60%, 50%, 45%, 40%, 35% or 30% by weight of one or more binders (all calculated on a dry weight basis). For example, the aerosolizable formulation or aerosol-generating system may comprise from about 5% to 70%, 7% to 60%, 10% to 50%, 15% to 45%, 17% to 40%, 20% to 35% or 25% to 30% by weight of one or more binders.

[0295] In some embodiments, the one or more adhesives comprise one or more gelling agents. In some embodiments, the one or more adhesives consist of one or more gelling agents. In some embodiments, the gelling agent comprises a hydrocolloid.

[0296] In some embodiments, the one or more binders comprise (or are) one or more compounds selected from the group consisting of: polysaccharide gelling agents such as alginates, pectins, starches or derivatives thereof, cellulose or derivatives thereof, pullulan, carrageenan, agar, and agarose; gelatin; gums such as tannin, guar gum, and gum arabic; silicon dioxide or silicone compounds such as PDMS and sodium silicate; clays such as kaolin; and polyvinyl alcohol.

[0297] In some embodiments, the one or more adhesives comprise (or are) one or more polysaccharide gelling agents. In some embodiments, the polysaccharide gelling agent is selected from alginate, pectin, starch or a derivative thereof, or cellulose or a derivative thereof. In some embodiments, the polysaccharide gelling agent is selected from alginate and a cellulose derivative.

[0298] In some embodiments, the one or more binders are polysaccharide gelling agents, optionally wherein the polysaccharide gelling agent is selected from alginates and cellulose derivatives. In some embodiments, the polysaccharide gelling agent is alginate. In some embodiments, the alginate is sodium alginate.

[0299] In some embodiments, the polysaccharide gelling agent is a cellulose derivative. Without wishing to be bound by theory, it is believed that such gelling agents do not react with calcium ions to form crosslinks. In some embodiments, the binder is not crosslinked. The absence of crosslinks in the gelling agent can promote faster delivery of the consumable (and any optional additional active substances and / or flavorings) from the aerosolizable formulation or aerosol generating system.

[0300] Examples of cellulose binders (also referred to herein as cellulose gelling agents or cellulose derivatives) include, but are not limited to, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose (CMC), hydroxypropyl methyl cellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP). In some embodiments, the cellulose or its derivative is selected from hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose (CMC), hydroxypropyl methyl cellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP). In some embodiments, the cellulose derivative is CMC. For example, in some embodiments, the binder comprises (or is) one or more of alginate, pectin, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, pullulan, tannin gum, guar gum, carrageenan, agarose, gum arabic, fumed silica, PDMS, sodium silicate, kaolin, and polyvinyl alcohol.

[0301] In some embodiments, the binder comprises (or is) one or more of hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, guar gum, gum arabic, alginate, and / or pectin.

[0302] In some cases, the binder comprises (or is) alginate and / or pectin and can be combined with a setting agent (such as a calcium source) during formation of the aerosolizable formulation or aerosol-generating system. In some cases, the binder can comprise calcium-crosslinked alginate and / or calcium-crosslinked pectin.

[0303] In some embodiments, the binder comprises (or is) alginate, optionally wherein the alginate is present in the aerosolizable formulation in an amount of about 5-70%, 7-60%, 10-50% or 15-45% by weight of the aerosolizable formulation or aerosol generating system (calculated on a dry weight basis).

[0304] In some embodiments, alginate is the only adhesive present in aerosolizable formulation / aerosol generating system. In other embodiments, adhesive comprises alginate and at least one other adhesive, such as pectin. In particular embodiments, adhesive is carboxymethyl cellulose, optionally wherein carboxymethyl cellulose (CMC) is with about 2 to 80 weight %, for example, about 5-70 weight %, 10-60 weight %, 15-50 weight %, 17-45 weight %, 20-40 weight % or about 30 weight % amount exists. In some embodiments, CMC is the only adhesive present in aerosolizable formulation / aerosol generating system.

[0305] filler

[0306] The aerosolizable formulation or aerosol-generating system may further comprise a filler. For example, if a high content of aerosol-forming material is present, the use of a filler can help reduce the viscosity of the aerosolizable formulation / aerosol-generating system. Suitably, the aerosolizable formulation / aerosol-generating system comprises from about 2% to about 60% by weight of a binder and any optional filler.

[0307] In some embodiments, the filler is present in an amount of less than about 50% by weight filler, such as from about 1% to 50% by weight, or from 5% to 40% by weight, or from 5% to 30% by weight, or from 10% to 20% by weight. In other embodiments, the filler is present in an amount of less than 20% by weight, suitably less than 10% by weight or less than 5% by weight. In some cases, the aerosolizable formulation / aerosol-generating system comprises less than 1% by weight filler, and in some cases, comprises no filler.

[0308] The filler, if present, may comprise one or more inorganic filler materials such as calcium carbonate, perlite, vermiculite, diatomaceous earth, colloidal silica, magnesium oxide, magnesium sulfate, magnesium carbonate, and suitable inorganic adsorbents such as molecular sieves. The filler may comprise one or more organic filler materials such as wood pulp; tobacco pulp; hemp fiber; starch and starch derivatives such as maltodextrin; chitosan; and cellulose and cellulose derivatives such as ground cellulose, microcrystalline cellulose, and nanocrystalline cellulose. In certain instances, the aerosolizable formulation does not comprise calcium carbonate, such as chalk.

[0309] In certain embodiments that include a filler, the filler is fibrous. For example, the filler can be a fibrous organic filler material, such as wood pulp, tobacco pulp, hemp fiber, cellulose, or a cellulose derivative. In some embodiments, the fibrous organic filler material can be wood pulp, hemp fiber, cellulose, or a cellulose derivative. In some embodiments, the fibrous filler is wood pulp. Without wishing to be bound by theory, it is believed that including a fibrous filler in an aerosolizable formulation can increase the tensile strength of the material. This can be particularly advantageous in instances where the aerosolizable formulation or aerosol generating system is provided as a sheet, such as when the sheet surrounds a rod of an aerosolizable or aerosol generating material.

[0310] Plant materials

[0311] In some embodiments, the aerosolizable formulation or aerosol-generating system comprises plant material.

[0312] As used herein, the term "plant material" includes any material derived from a plant, including, but not limited to, extracts, leaves, bark, fibers, stems, roots, seeds, flowers, fruits, pollen, rinds, shells, and the like. Alternatively, the material may contain active compounds naturally present in the plant material or obtained synthetically. The material may be in the form of a liquid, gas, solid, powder, dust, pulverized particles, granules, pellets, chips, strips, flakes, and the like.

[0313] Exemplary plant materials are tobacco, eucalyptus, star anise, hemp, cocoa, fennel, lemongrass, peppermint, spearmint, rooibos, chamomile, flax, ginger, ginkgo, hazelnut, hibiscus, bay, licorice, matcha, mate, orange peel, papaya, rose, sage, tea (such as green or black tea), thyme, cloves, cinnamon, coffee, anise seed (anise), basil, bay leaf, cardamom, coriander, cumin, nutmeg, oregano, paprika, rosemary , saffron, lavender, lemon peel, mint, juniper, elderflower, vanilla, wintergreen, basil, turmeric (curcuma or turmeric), sandalwood, cilantro, bergamot, orange blossom, myrtle, black currant, valerian, pimento, mace, damian, marjoram, olive, lemon balm, lemon basil, chives, coriander, verbena, tarragon, geranium, mulberry, ginseng, theanine, theophylline, maca, ashwagandha, damiana, guarana, chlorophyll, baobab, or any combination thereof. The mint may be selected from the following mint varieties: wild mint (Mentha arvensis), mint cultivars (Mentha cv), Egyptian mint (Menthaniliaca), peppermint (Mentha piperita), lemon peppermint cultivars (Mentha piperita citratac.v.), peppermint cultivars (Mentha piperita cv), Moroccan mint (Mentha spicata crispa), heart mint (Mentha cordifolia), horse mint (Mentha longifolia), pineapple mint (Mentha suaveolens variegata), spearmint cultivars (Mentha spicata cv) and apple mint (Mentha suaveolens).

[0314] In some embodiments, the plant material is tobacco. In some embodiments, the plant material is selected from eucalyptus, star anise, cocoa, and hemp. In some embodiments, the plant material is selected from rooibos and fennel.

[0315] Aerosol-forming material

[0316] Aerosol-forming agent material can include one or more components that can form aerosol. Suitably, the aerosolizable formulation or aerosol generating system can include an aerosol-forming agent material (calculated by dry weight) of about 5 wt % to about 30 wt %, for example, about 7 wt %, 10 wt % or 12 wt % to about 15 wt %, 17 wt %, 20 wt % or 25 wt %. In some embodiments, the aerosolizable formulation or aerosol generating system can include about 5 to 25 wt % aerosol-forming agent material. In some embodiments, the aerosolizable formulation or aerosol generating system can include about 5 to 20 wt %, such as about 5 to 15 wt % aerosol-forming agent material. In some embodiments, the aerosolizable formulation or aerosol generating system can include about 10 to 20 wt % aerosol-forming agent material.

[0317] In some embodiments, the aerosol-forming material may comprise one or more of the following: glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, ethyl vanillate, ethyl laurate, diethyl suberate, benzyl benzoate, benzyl phenylacetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.

[0318] In some embodiments, the aerosol-forming material can comprise one or more of propylene glycol or glycerol. In some cases, the aerosol-forming material comprises, consists essentially of, or consists of glycerol or a mixture of glycerol and propylene glycol.

[0319] In some embodiments, the aerosol-former material comprises a mixture of glycerol and propylene glycol, with a weight ratio of glycerol to propylene glycol of about 3:1 to 1:3, about 2:1 to 1:2, about 1.5:1 to 1:1.5, about 55:45 to 45:55, or about 45:55.

[0320] The aerosol-forming material can act as a plasticizer. If the plasticizer content is too high, the aerosolizable formulation can absorb water, resulting in a material that does not produce an appropriate consumer experience during use. If the plasticizer content is too low, the aerosolizable formulation can be brittle and easily break. The plasticizer content specified herein provides aerosolizable formulation flexibility, which allows sheets of the aerosolizable formulation or aerosol-generating composition to be wound onto a spool, which is useful in the manufacture of aerosol-generating articles.

[0321] Other ingredients

[0322] The aerosolizable formulation or aerosol generating system may include one or more additional ingredients. In particular, one or more additional ingredients may be selected from one or more active agents and / or one or more functional ingredients. In some embodiments, the active agent is a physiologically active agent and may be selected from nicotine, nicotine salts (e.g., nicotine tartrate / nicotine bitartrate), nicotine-free tobacco substitutes, other alkaloids (such as caffeine) or mixtures thereof. In other embodiments, the aerosolizable formulation or aerosol generating system is nicotine-free, which means that nicotine is not included in the aerosolizable formulation or aerosol generating system.

[0323] "Active agent" refers to an agent that has a biological effect (such as a sensory and / or physiological effect) on a subject when the aerosol is inhaled. In one aspect, "active agent" refers to an agent that has a physiological effect on a subject when the aerosol is inhaled. In some cases, the active agent may be a flavoring. The active agent may also be selected from a nutrient, a nootropic, a psychotropic, and a sensory agent, wherein the sensory agent is a sensory agent other than one or more sensory agents present in the consumable. In some embodiments, the active agent is selected from a nutrient, a nootropic, and a psychotropic. The active substance may be naturally occurring or obtained synthetically.

[0324] The activating agent can comprise, for example, nicotine, caffeine, taurine, theophylline, vitamins (such as B6 or B12 or C), melatonin, or a component, derivative, or combination thereof. The activating agent can comprise one or more components, derivatives, or extracts of tobacco or another plant material. In some embodiments, the activating agent comprises caffeine, melatonin, or vitamin B12. The one or more activating agents can be selected from nicotine, plant material, and mixtures thereof. The one or more activating agents can be synthetic or naturally derived. The activating agent can be from plant material, such as from an extract of a Nicotiana plant as discussed above. In one aspect, the activating agent is at least nicotine. In one aspect, the activating agent is composed of nicotine and / or its salt as discussed above.

[0325] As described herein, the active agent may comprise or be derived from one or more plant materials or components, derivatives or extracts thereof. In some embodiments, the active agent comprises or is derived from one or more plant materials or components, derivatives or extracts thereof, and the plant material is tobacco. In some embodiments, the active agent comprises or is derived from one or more plant materials or components, derivatives or extracts thereof, and the plant material is selected from eucalyptus, star anise, cocoa and hemp. In some embodiments, the active agent comprises or is derived from one or more plant materials or components, derivatives or extracts thereof, and the plant material is selected from rooibos and fennel.

[0326] When nicotine is present in the formulation, it may be present in protonated and / or unprotonated form. In some embodiments, the formulation comprises nicotine in an unprotonated form and nicotine in a monoprotonated form. Small amounts of diprotonated nicotine may also be present. In one aspect, the formulation comprises nicotine in an unprotonated form, nicotine in a monoprotonated form, and nicotine in a diprotonated form.

[0327] As discussed herein, the formulation may additionally comprise nicotine in an unprotonated form and nicotine in a protonated form. As will be appreciated by one of ordinary skill in the art, the protonated form of nicotine can be prepared by reacting unprotonated nicotine with an acid. The one or more acids are one or more suitable acids, such as organic acids. In some embodiments, the acid is a carboxylic acid. The carboxylic acid may be any suitable carboxylic acid. In some embodiments, the acid is a monocarboxylic acid. In some embodiments, the acid is selected from the group consisting of acetic acid, benzoic acid, levulinic acid, lactic acid, formic acid, citric acid, pyruvic acid, succinic acid, tartaric acid, oleic acid, sorbic acid, propionic acid, phenylacetic acid, and mixtures thereof. In some embodiments, the acid is benzoic acid and / or levulinic acid. In some embodiments, the acid is benzoic acid.

[0328] In alternative embodiments, the aerosolizable formulation may be free of organic or inorganic acids and their corresponding salts. For example, the aerosolizable formulation may be free of carboxylic acids and free of phosphoric acid.

[0329] In the case of existence, the amount of organic acid can vary. Based on the gross weight of the preparation, the preparation can include an organic acid of approximately 0.01 % by weight to approximately 10 % by weight, which exists as one or more organic acids. In some embodiments, based on the gross weight of the preparation, the preparation includes at least about 0.01 % by weight, at least about 0.1 % by weight, about 0.2 % by weight, about 0.3 % by weight, about 0.4 % by weight, about 0.5 % by weight, about 0.6 % by weight, about 0.7 % by weight, about 0.8 % by weight, about 0.9 % by weight, about 1 % by weight, about 2 % by weight, about 3 % by weight, about 4 % by weight, about 5 % by weight, about 6 % by weight, about 7 % by weight, about 8 % by weight, about 9 % by weight or at least about 10 % by weight of organic acid. In some preferred embodiments, the preparation includes an organic acid of approximately 0.01 % by weight to approximately 5 % by weight. For example, the formulation comprises an organic acid in an amount of about 0.1 wt % to about 2.5 wt % based on the weight of the formulation. In the case of adding a salt of an organic acid (e.g., anhydrous citric acid), the weight percentage is calculated based on the weight of the free acid, excluding any counterions that may be present.

[0330] In some embodiments, the additional ingredients are selected from "flavorings" and / or "flavorants," which, where permitted by local regulations, may be used to create a desired taste or aroma in products for adult consumers. One of ordinary skill in the art will recognize that, in the context of the present disclosure, flavorings or flavorants are not sensate compounds as defined herein. In some cases, the flavoring or flavoring agent may include one or more extracts, for example, licorice, hydrangea, Japanese magnolia leaves, chamomile, fenugreek, cloves, Japanese mint, anise seeds, cinnamon, herbs, wintergreen, cherry, berry, peach, apple, Dolin brand liqueur, bourbon, Scotch whisky, whiskey, spearmint, peppermint, lavender, cardamom, celery, cardamom, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, cinnamon, caraway, cognac, jasmine, ylang-ylang, sage, fennel, bell pepper, anise, coriander, coffee and other additives, such as charcoal, chlorophyll, minerals or plant materials. They can be imitations, synthetic or natural ingredients or blends thereof. They can be in any suitable form, such as oil, liquid or powder.

[0331] The flavoring agent may be added to the aerosolizable formulation as part of a so-called "flavoring agent block," wherein one or more flavoring agents are blended together and then added to the aerosolizable material. The "flavoring agent block" may optionally include one or more of the sensate compounds defined herein.

[0332] Where present, the flavoring agent may be included in the formulation in an amount of up to about 10% by weight, such as up to about 5% by weight, such as up to about 1% by weight, based on the weight of the formulation. In some embodiments, the flavoring agent is present in an amount of from about 0.01% to about 5% by weight, preferably from about 0.1% to about 2.5% by weight, and more preferably from about 0.25% to about 1% by weight, based on the weight of the formulation.

[0333] The one or more other functional ingredients can comprise one or more in coloring agent, preservative, adhesive and / or filler.For example, filler can realize multiple functions, such as enhancing some organoleptic properties (such as texture and mouthfeel), enhancing the cohesiveness or the compressibility etc. of the product. The above text sets forth more details. In certain embodiments, adhesive (or the combination of adhesives) can be enough to provide the amount of the physical attribute of expectation and physical integrity to the product for the product. The above text sets forth more details. Coloring agent can be enough to provide the amount of the physical attribute of expectation to the product and use.

[0334] In some embodiments, the aerosolizable material comprises less than 12% w / w water. In some embodiments, the aerosolizable material comprises less than 11% w / w water. In some embodiments, the aerosolizable material comprises less than 10% w / w water. In some embodiments, the aerosolizable material comprises less than 5% w / w water. In some embodiments, the aerosolizable material comprises less than 1% w / w water. In some embodiments, the aerosolizable material comprises less than 0.5% w / w water. In some embodiments, the aerosolizable material is substantially free of water.

[0335] Concentration and weight ratio

[0336] In some embodiments, the aerosolizable formulation or aerosol-generating system comprises a consumable as defined herein, wherein the formulation or system comprises from about 0.0001 wt % to about 5 wt % of the one or more sensates, wherein at least one sensate is a warming agent or a tingling agent; a sweetener; and from greater than about 1 wt % to less than about 35 wt % of at least one compound (iii), the wt % values being based on the total weight of the formulation or system, optionally wherein the weight ratio of the one or more sensates to the sweetener is from greater than about 1:1 to about 3:1. The weight ratios can be adjusted according to expression (1) above, i.e., for sweetness potency.

[0337] In some embodiments, the aerosolizable formulation or aerosol-generating system comprises a consumable as defined herein, wherein the formulation or system comprises from about 0.0001 wt % to about 4 wt % of the one or more sensates, wherein at least one sensate is a warming agent or a tingling agent; a sweetener; and from greater than about 1 wt % to less than about 30 wt % of at least one compound (iii), the wt % values being based on the total weight of the formulation or system, optionally wherein the weight ratio of the one or more sensates to the sweetener is from greater than about 1:1 to about 3:1. The weight ratios can be adjusted according to expression (1) above, i.e., for sweetness potency.

[0338] In some embodiments, the aerosolizable formulation or aerosol-generating system comprises a consumable as defined herein, wherein the formulation or system comprises from about 0.0001 wt % to about 2.5 wt % of the one or more sensates, wherein at least one sensate is a warming agent or a tingling agent; a sweetener; and from greater than about 1 wt % to less than about 20 wt % of at least one compound (iii), the wt % values being based on the total weight of the formulation or system, optionally wherein the weight ratio of the one or more sensates to the sweetener is from greater than about 1:1 to about 3:1. The weight ratios may be adjusted according to expression (1) above, i.e., for sweetness potency.

[0339] According to the above embodiments, such embodiments may also be defined by the concentration of consumables, carriers and / or nicotine. It should be understood that for the sake of brevity, such features will not be repeated here.

[0340] Since the aerosolizable formulation and aerosol-generating system embodiments include consumables as defined herein, it should be understood that the components of the consumables, such as the sensate, including the warming agent, tingling agent, and optional cooling agent; the sweetener; the at least one compound (iii); and any other ingredients are as defined above. For the sake of brevity, this definition will not be repeated here, but it applies equally to the description of the aerosolizable formulation and the aerosol-generating system.

[0341] The one or more sensates defined herein may be present in the formulation in an amount of from about 0.0001% to about 5% by weight, based on the total weight of the formulation. As will be understood by one of ordinary skill in the art, this concentration range applies to the total amount of sensates (e.g., warming or tingling agents and optional cooling agents). A concentration range of from about 0.0001% to about 5% by weight also applies to the above definition of the one or more sensates. For example, the consumable may contain from about 0.0001% to about 5% by weight of one or more sensates, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent is selected from the group consisting of vanilloids, sanshool, piperine, cinnamylphenylpropyl compounds, ethyl esters, and combinations thereof, or an extract from at least one of the following: ginger oil, black pepper, long pepper, Sichuan pepper, red pepper, or Uzazi. Preferably, the warming or tingling agent comprises a vanilloid, such as 3-phenylpropyl homovanillate.

[0342] In some embodiments, one or more sensates as defined herein are present in the consumable in an amount of about 0.0001 wt % to about 3 wt %, such as about 0.0001 wt % to about 2.5 wt %, preferably about 0.0001 wt % to about 1 wt %, based on the total weight of the aerosolizable formulation.

[0343] In some embodiments, the one or more sensates are present in the aerosolizable formulation in an amount of from about 0.0001% to about 5% by weight, based on the total weight of the aerosolizable formulation, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent comprises a vanillin. In some embodiments, the one or more sensates as defined herein are present in the aerosolizable formulation in an amount of from about 0.0001% to about 3% by weight, based on the total weight of the aerosolizable formulation, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent comprises a vanillin. In some embodiments, the one or more sensates as defined herein are present in the formulation in an amount of from about 0.0001% to about 2.5% by weight, based on the total weight of the aerosolizable formulation, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent comprises a vanillin. In some embodiments, one or more sensates as defined herein are present in the aerosolizable formulation in an amount of about 0.0001% to about 1% by weight, based on the total weight of the formulation, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent comprises a vanillin. In some embodiments, one or more sensates as defined herein are present in the formulation in an amount of about 0.0001% to about 0.1% by weight, based on the total weight of the aerosolizable formulation, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent comprises a vanillin.

[0344] In some embodiments, the warming or tingling agent is present at a concentration of about 0.0001% to about 0.005% by weight, based on the total weight of the aerosolizable formulation. A concentration range of about 0.0001% to about 0.005% by weight can be combined with any of the above concentrations of the total amount of sensate.

[0345] In some embodiments, the one or more sensates consist of a warming agent or a tingling agent such that the "total" concentration of the one or more sensates is from about 0.0001 wt % to about 5 wt %, preferably from about 0.0001 wt % to about 3 wt %, based on the total weight of the aerosolizable formulation.

[0346] For each concentration range, the warming or tingling agent may be defined as described above. For example, the warming or tingling agent may comprise a vanillin.

[0347] The absolute concentration of the sweetener is not critical for the present disclosure. In some embodiments, the weight ratio of one or more sensory agents to the sweetener is greater than about 1: 1 to about 3: 1, such as greater than about 1: 1 to about 2: 1, preferably wherein the weight ratio of one or more sensory agents to the sweetener is about 2: 1. When the sweetener is not neotame, the weight ratio can be adjusted according to the above-mentioned expression (1) or (2). However, the sweetener can be present in an amount of about 0.0001 weight % to about 5 weight %, such as about 0.0001 weight % to about 3 weight %, preferably about 0.0001 weight % to about 2.55 weight %, more preferably about 0.0001 weight % to about 1 weight %. In a particularly preferred embodiment, based on the gross weight of the formulation, the sweetener can be present in an amount of about 0.0001 to 0.1 weight %. When the sweetener is not neotame, the sweetener concentration can be adjusted according to the above-mentioned expression (3). In some embodiments, the formulation comprises one or more sensates in an amount of about 0.0001% to about 5% by weight, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001% to about 5% by weight; a sweetener in an amount of about 0.0001% to about 5% by weight; and an emulsifier compound (iii) in an amount of greater than about 1% to less than about 35% by weight, wherein the sensate, warming agent / tingling agent, sweetener, and emulsifier compound (iii) are defined according to the above embodiments, and the weight % values are based on the total weight of the aerosolizable formulation. When the sweetener is not neotame, the sweetener concentration can be adjusted according to the above expression (3).

[0348] In some embodiments, the formulation comprises one or more sensates in an amount of about 0.0001% to about 3% by weight, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001% to about 3% by weight; a sweetener in an amount of about 0.0001% to about 3% by weight; and an emulsifier compound (iii) in an amount of greater than about 1% to less than about 30% by weight, wherein the sensate, warming agent / tingling agent, sweetener, and emulsifier compound (iii) are defined according to the above embodiments, and the weight % values are based on the total weight of the aerosolizable formulation. When the sweetener is not neotame, the sweetener concentration can be adjusted according to the above expression (3).

[0349] In some embodiments, the formulation comprises one or more sensates in an amount of about 0.0001% to about 2.5% by weight, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001% to about 2.5% by weight; a sweetener in an amount of about 0.0001% to about 2.5% by weight; and an emulsifier compound (iii) in an amount of greater than about 1% to less than about 20% by weight, wherein the sensate, warming agent / tingling agent, sweetener, and emulsifier compound (iii) are defined according to the above embodiments, and the weight % values are based on the total weight of the aerosolizable formulation. When the sweetener is not neotame, the sweetener concentration can be adjusted according to the above expression (3).

[0350] In any of the above embodiments, the warming or tingling agent may comprise a vanillin (e.g., 3-phenylpropyl homovanillate), and the sweetener may be selected from compounds that bind T1R2 and / or T1R3, acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. Furthermore, the weight ratio of the one or more sensates to the sweetener may be greater than about 1:1 to about 3:1 (optionally adjusted according to expression (1) above).

[0351] In any of the above embodiments, the at least one compound (iii) may be selected from C4 to C 38 Hydrocarbyl maleate or fumarate, preferably C4 to C 38 Alkyl maleate or fumarate, C4 to C 18 Glycerides, C4 to C 38 lactone (preferably represented by the compound of formula (II)), C4 to C 38 Hydrocarbyl (preferably alkyl) polyols (the polyols optionally having at least three hydroxyl groups), and polyoxyethylene sorbitan fatty acid esters.

[0352] In some embodiments, the at least one compound (iii) is selected from C4 to C 16 Glycerides, C5 to C 38 lactone (preferably represented by the compound of formula (II)), C4 to C 18 Hydrocarbyl (preferably alkyl) polyols (the polyols optionally having at least three hydroxyl groups), and polyoxyethylene sorbitan fatty acid esters.

[0353] In some embodiments, the at least one compound (iii) is selected from C4 to C 12 Glycerides, C6 to C 16 lactone (preferably represented by the compound of formula (II)), C4 to C 16A hydrocarbon group (preferably an alkyl group), a polyol (the polyol optionally having at least three hydroxyl groups), and a polyoxyethylene sorbitan fatty acid ester.

[0354] In some embodiments, the at least one compound (iii) is selected from C4 to C 12 Glycerides, C6 to C 16 lactone (preferably represented by the compound of formula (II)), C4 to C 16 an alkyl polyol, the polyol optionally having at least three hydroxyl groups, and a polyoxyethylene sorbitan fatty acid ester.

[0355] The at least one compound (iii) may be present in an amount of about 1% to less than about 35% by weight of the aerosolizable formulation. In some embodiments, the at least one compound (iii) may be present in an amount of about 1% to less than about 30% by weight of the aerosolizable formulation.

[0356] In some embodiments, the aerosolizable formulations of the present disclosure include greater than about 5% to less than about 20% by weight of triacetin. Triacetin is an organic compound having the chemical formula shown in Appendix 1. It is classified as a triglyceride, i.e., a triester of glycerol, and is a common food additive, for example, as a solvent in flavorings and for its emulsifying or moisturizing properties. It is available from various commercial sources.

[0357] Based on the total weight of the aerosolizable formulation, triacetin may be present in an amount of greater than about 8 wt% to less than about 20 wt%, such as greater than about 8 wt% to less than about 18 wt%, preferably greater than about 10 wt% to less than about 18 wt%, and more preferably greater than about 10 wt% to less than about 14 wt%.

[0358] In some embodiments, the formulation comprises one or more sensates in an amount from about 0.001% to about 1% by weight, wherein at least one sensate is a warming or tingling agent and the warming or tingling agent is present at a concentration from about 0.001% to about 0.05% by weight; a sweetener in an amount from about 0.001% to about 0.5% by weight; and from greater than about 8% to less than about 20% by weight of triacetin, the sensates, warming / tingling agents, and sweetener being defined according to the above embodiments.

[0359] In some embodiments, the formulation comprises one or more sensates in an amount from about 0.001% to about 0.5% by weight, wherein at least one sensate is a warming or tingling agent and the warming or tingling agent is present at a concentration from about 0.001% to about 0.05% by weight; a sweetener in an amount from about 0.001% to about 0.1% by weight; and greater than about 8% to less than about 18% by weight of triacetin, the sensates, warming / tingling agents, and sweetener being defined according to the above embodiments.

[0360] In some embodiments, the formulation comprises one or more sensates in an amount from about 0.001% to about 0.25% by weight, wherein at least one sensate is a warming or tingling agent and the warming or tingling agent is present at a concentration from about 0.001% to about 0.05% by weight; a sweetener in an amount from about 0.001% to about 0.05% by weight; and greater than about 10% to less than about 18% by weight of triacetin, the sensates, warming / tingling agents, and sweetener being defined according to the embodiments above.

[0361] In some embodiments, the formulation comprises one or more sensates in an amount from about 0.001% to about 0.1% by weight, wherein at least one sensate is a warming or tingling agent and the warming or tingling agent is present at a concentration from about 0.001% to about 0.005% by weight; a sweetener in an amount from about 0.001% to about 0.025% by weight; and greater than about 10% to less than about 14% by weight of triacetin, the sensates, warming / tingling agents, and sweetener being defined according to the above embodiments.

[0362] In any of the above embodiments, the warming or tingling agent may comprise a vanillin (e.g., 3-phenylpropyl homovanillate), and the sweetener may be selected from compounds that bind T1R2 and / or T1R3, acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. Furthermore, the weight ratio of the one or more sensates to the sweetener may be greater than about 1:1 to about 3:1 (optionally adjusted according to expression (1) above).

[0363] The present inventors have discovered that the amounts of one or more sensates, sweeteners, and emulsifiers (e.g., triacetin) as described above provide a beneficial effect of modulating or improving at least one sensory characteristic of the aerosolizable formulation. The sensory characteristic may be selected from taste, mouthfeel, smoking experience, or a combination thereof, in order to replicate smoking a cigarette while ensuring consumer safety.

[0364] Products, aerosol delivery systems and containers

[0365] In another aspect, an article is provided, comprising an aerosolizable formulation as defined herein. The article may be a container, such as a bottle, or an assembly that can be used with an aerosol supply device. For example, the article may comprise an area for receiving an aerosolizable formulation as defined herein (a reservoir), an aerosol-generating assembly, an aerosol-generating region, and optionally a mouthpiece.

[0366] In some embodiments, there is provided an article for use with an aerosol supply system, the article comprising a reservoir containing an aerosolizable formulation as defined herein, an aerosol-generating component (such as a heater), an aerosol-generating region, a delivery element, and a mouthpiece.

[0367] The aerosolizable material (aerosolizable formulation) can be transferred from the reservoir for receiving the aerosolizable material to the aerosol-generating assembly via a delivery element (such as a wick, a pump, etc.). A skilled person will be able to select a suitable delivery element depending on the type of aerosolizable material to be delivered and the rate at which it must be delivered. In particular, delivery elements, such as wicks, formed from fibrous materials, foamed materials, sintered materials, woven materials, and non-woven materials are mentioned.

[0368] The airflow path typically extends through the article (optionally through the device) to the outlet. The path is oriented so that the generated aerosol is entrained in the airflow so that it can be delivered to the outlet for inhalation by the user.

[0369] In some embodiments, the aerosol-generating component is a heater.

[0370] Typically, the area for receiving the aerosolizable material will allow the article to be refilled with aerosolizable material if said aerosolizable material is depleted during use.

[0371] In another aspect, there is provided an aerosol supply system comprising an aerosol supply device and an article as defined herein.The aerosol supply system is preferably non-flammable. Non-flammable aerosol supply system is System for releasing compounds from an aerosol-generating material without burning the aerosol-generating material , such as electronic cigarettes, tobacco heating products, and hybrid systems, to generate aerosols using a combination of aerosol-generating materials. According to the present disclosure, a "non-combustible" aerosol supply system is an aerosol supply system in which the component aerosol-generating materials of the aerosol supply system (or its components) are not burned or ignited in order to deliver at least one substance to the user. The system can heat the aerosol-generating material / system or the aerosolizable formulation or the consumables / formulations of the system to a temperature of at least about 200°C, preferably at least about 250°C. In some embodiments, the aerosol supply system generates the aerosol by heating to a temperature of about 250°C to about 400°C.

[0372] The aerosol supply system may also be referred to herein as an aerosol delivery system. In some embodiments, the delivery system is a non-combustible aerosol supply system, such as an electrically powered non-combustible aerosol supply system. In some embodiments, the non-combustible aerosol supply system is an electronic cigarette, also known as an inhalation device or an electronic nicotine delivery system (END), but it should be noted that nicotine is not required to be present in the aerosol-generating material.

[0373] In some embodiments, the non-combustible aerosol supply system is an aerosol generating material heating system, also known as a heat-not-burn system. An example of such a system is a tobacco heating system.

[0374] In some embodiments, the non-combustible aerosol delivery system is a hybrid system that uses a combination of aerosol-generating materials to generate an aerosol, one or more of which may be heated. Each of the aerosol-generating materials may be, for example, in the form of a solid, liquid, or gel, and may or may not contain nicotine. In some embodiments, the hybrid system comprises a liquid or gel aerosol-generating material and a solid aerosol-generating material. The solid aerosol-generating material may comprise, for example, a tobacco or non-tobacco product.

[0375] Typically, the non-flammable aerosol supply system may include a non-flammable aerosol supply device and consumables for use with the non-flammable aerosol supply device. The consumables are as defined herein.

[0376] In some embodiments, the non-flammable aerosol supply system, such as a non-flammable aerosol supply device thereof, may include a power source and a controller. The power source may be, for example, an electrical power source or an exothermic power source. In some embodiments, the exothermic power source comprises a carbon matrix that can be energized to distribute electricity in the form of heat to the aerosol-generating material or a heat transfer material adjacent to the exothermic power source.

[0377] Figure 1 A highly schematic diagram (not to scale) of an exemplary aerosol delivery system, such as an electronic cigarette 10, to which embodiments may be applied, but not limited, is shown. The electronic cigarette has a generally cylindrical shape extending along a longitudinal axis indicated by a dashed line (although aspects of the present invention are applicable to electronic cigarettes constructed in other shapes and configurations), and includes two primary components, an aerosol delivery device 20 and an article 30.

[0378] The article 30 includes a reservoir 38 of aerosolizable material (source liquid) containing the aerosolizable material (source liquid) that generates the aerosol. The article 30 further includes an aerosol-generating component (heating element or heater) 36 for heating the aerosolizable material to generate the aerosol. A transport element or wicking element or core 37 is provided to deliver the aerosolizable material from the reservoir 38 to the heating element 36. A portion or portions of the core 37 are in fluid communication with the aerosolizable material in the reservoir 38, and the aerosolizable material is drawn along or through the core 37 by wicking or capillary action to one or more portions of the core 37 that are in contact with the heater 36.

[0379] The aerosol is generated by applying heat energy to the aerosolizable material to cause evaporation, thereby vaporizing the aerosolizable material at the interface between the wick 37 and the heater 36. The aerosolizable material, the wick 37, and the heater 36 may be collectively referred to as an aerosol or vapor source. The wick 37 and the heater 36 may be collectively referred to as a vaporizer or atomizer 15.

[0380] Typically, there will be a single core, but it is envisaged that there may be more than one core, for example two, three, four or five cores.

[0381] As described above, the core may be formed of a sintered material. The sintered material may comprise sintered ceramic, sintered metal fiber / powder, or a combination of the two. A resistive heater may be deposited on / embedded in the sintered core (or at least one / all of the sintered cores). Such a heater may be formed of a thermally conductive alloy (such as a NiCr alloy). Alternatively, the sintered material may have electrical properties that heat it when an electric current passes through it. Therefore, the aerosol generating component and the core may be considered to be integrated. In some embodiments, the aerosol generating component and the core are formed of the same material and form a single component.

[0382] In some embodiments, the core is formed of a sintered metal material and is typically in the form of a planar sheet. Thus, the core element can have a substantially thin, flat shape. For example, it can be considered a sheet, layer, film, matrix, etc. By this, it is meant that the thickness of the core is less than or significantly less than at least one of the length and width of the core. Thus, the core thickness (its smallest dimension) is less than or significantly less than its longest dimension.

[0383] The core may be made of one or more homogeneous, granular, fibrous or flocculent sintered metals to form the capillary structure. The core element may be made of a conductive material, which is a non-woven sintered porous mesh structure containing metal fibers (such as stainless steel fibers). For example, the stainless steel may be American Iron and Steel Institute (AISI) 316L (corresponding to European Standard 1.4404). The weight of the material may be between 100 and 300 g / m 2 within the range.

[0384] Where the core is generally planar, the core thickness may be in the range of 75-250 μm. A typical fiber diameter may be about 12 μm, and a typical average pore size (the size of the spaces between the fibers) may be about 32 μm. An example of this type of material is Bekipor (RTM) ST porous metal fiber media manufactured by NV Bekaert SA of Belgium, which is a series of porous nonwoven fiber matrix materials made by sintering stainless steel fibers.

[0385] It should also be noted that while the material is described as planar, this refers to the relative dimensions of the sheet material and the core (thickness being many times smaller than length and / or width), but does not necessarily indicate flatness, particularly the flatness of the final core made from the material. The core may be flat, but alternatively may be formed from the sheet material into non-flat shapes, such as curved, undulating, corrugated, ridged, formed into a tube, or otherwise made concave and / or convex.

[0386] The core element can have a variety of properties. The core element is formed of a porous material to achieve the desired wicking or capillary action so that the source liquid is drawn from the reservoir of aerosolizable material (when the core meets the aerosolizable material at the reservoir contact site) to the vaporization interface. Porosity is typically provided by a plurality of interconnected or partially interconnected pores (holes or gaps) throughout the material and is open to the outer surface of the material. Any level of porosity can be adopted depending on the material, pore size and desired wicking rate. For example, a porosity between 30% and 85% can be selected, such as between 40% and 70%, between 50% and 80%, between 35% and 75%, or between 40% and 75%. This can be an average porosity value for the entire core element because the porosity can be uniform or not uniform across the core. For example, the pore size at the reservoir contact site can be different from the pore size closer to the heater.

[0387] It is useful for the core to have sufficient hardness to necessarily support itself within the article. For example, it may be mounted at or near one or both edges and needs to substantially maintain its position without flexing, bending or sagging. As an example, porous sintered ceramic is a useful material for use as a core element. Any ceramic with a suitable porosity can be used. If a porous ceramic is selected as the porous core material, it can be used as a powder that can be formed into a solid by sintering (heating to cause agglomeration, possibly under applied pressure). The ceramic is then sintered to solidify to produce a porous core.

[0388] The article 30 further comprises a mouthpiece 35 having an opening through which a user can inhale the aerosol generated by the vaporizer 15. The aerosol for inhalation can be described as an aerosol stream or an inhalable gas stream.

[0389] The aerosol delivery device 20 includes a power source (rechargeable battery or battery 14, hereinafter referred to as a battery) to power the electronic cigarette 10, and a controller (printed circuit board (PCB)) 28 and / or other electronic components for generally controlling the electronic cigarette 10. Therefore, the aerosol delivery device can also be considered a battery section, or a control unit or section.

[0390] During device operation, the controller will determine that the user has initiated a request to generate an aerosol. This can be accomplished via a button on the device, which signals the controller to supply power to the aerosol generator. Alternatively, a sensor located in or near the airflow path can detect the airflow through the airflow path and transmit this information to the controller. In addition to the presence of a button, a sensor may also be present, as it can be used to determine certain usage characteristics, such as airflow, the timing of aerosol generation, etc.

[0391] For example, in use, as controlled by the circuit board 28, possibly in response to pressure changes detected by an air pressure sensor (not shown), when the heater 36 receives power from the battery 14, the heater 36 vaporizes the aerosolizable material delivered by the wick 37 to produce the aerosol, and the user then inhales the aerosol stream through the opening in the mouthpiece 35. When the user inhales on the mouthpiece, the aerosol is moved along the air passage ( Figure 1 The aerosol (not shown) is carried from the aerosol source to the mouthpiece 35.

[0392] In this particular instance, Figure 1As shown, the device 20 and article 30 are detachable from each other by separation in a direction parallel to the longitudinal axis, but when the system 10 is in use, they are engaged together by cooperating engagement elements 21, 31 (e.g., screws, magnetic or bayonet fittings) to provide mechanical and electrical connections between the device 20 and article 30, and in particular to connect the heater 36 to the battery 14. The battery can be recharged as known to those skilled in the art.

[0393] In some embodiments, the article comprises / forms a sealed container. For example, the sealed container can be hermetically sealed. The hermetically sealed container can comprise a blister pack having one or more hermetically sealed compartments for storing one or more articles comprising the aerosolizable formulations described herein.

[0394] In some embodiments, the article comprises a shell in which the aerosolizable formulation is contained. The shell may be transparent so that the aerosolizable formulation can be observed from the outside of the shell. The shell may also have a certain degree of opacity so as to limit light from passing through the shell. This may be important in order to prevent light (such as ultraviolet light) from entering the shell and damaging the stability of the aerosolizable material. In some embodiments, the shell is formed by a material that suppresses / prevents ultraviolet light from passing therethrough. In some embodiments, the sealed container may be formed by a material with a certain degree of opacity so as to limit light from passing through the sealed container. In addition, the sealed container may be formed by a material that suppresses / prevents ultraviolet light from passing therethrough. This may be in addition to the sealed container being hermetically sealed and / or comprising a blister package with one or more hermetically sealed compartments for storing one or more articles comprising the aerosolizable material described herein.

[0395] Methods and uses

[0396] In some embodiments described herein, a method for forming an aerosol is provided, the method comprising providing an aerosolizable formulation as defined herein and aerosolizing the formulation. The method may alternatively comprise providing an aerosol generating system as defined herein or an aerosol supply system as defined herein, and aerosolizing the formulation or consumable in the system.

[0397] According to some embodiments, there is provided a use of about 0.0001% by weight to about 5% by weight of one or more sensates in combination with a sweetener and a compound in an aerosolizable formulation for adjusting at least one organoleptic characteristic of the formulation, wherein at least one sensate is a warming agent or a tingling agent, and the compound is an emulsifier, wherein the compound has a boiling point of at least about 200° C. at atmospheric pressure. The aerosolizable formulation may be characterized by any of the features defined and discussed herein. The emulsifier function and boiling point of the compound correspond to those discussed above for “compound (iii)” of the consumable. However, the use is not necessarily limited to esters, polyols, or fatty acid esters as defined above.

[0398] According to other embodiments, there is provided the use of about 0.0001% to about 5% by weight of one or more sensates in an aerosolizable formulation in combination with a sweetener and a compound for modifying at least one sensory characteristic of the formulation, wherein at least one sensate is a warming agent or a tingling agent, the compound is an emulsifier, and is C4 to C 38 Hydrocarbon esters, C4 to C 38 Hydrocarbyl polyols, or polyoxyalkylene fatty acid esters. The aerosolizable formulation may be characterized by any of the features defined and discussed herein. The emulsifier function and chemical properties of the compound correspond to those discussed above for "compound (iii)" of the consumable. However, the use is not necessarily limited to a boiling point of at least about 200°C as defined above.

[0399] According to some embodiments described herein, there is provided the use of about 0.0001% to about 1% by weight of one or more sensates in combination with a sweetener and triacetin in an aerosolizable formulation for improving at least one sensory characteristic of the formulation, wherein at least one sensate is a warming or tingling agent. The aerosolizable formulation can be characterized by any of the characteristics defined and discussed herein.

[0400] In some embodiments, the use comprises modulating or improving at least one sensory characteristic selected from the group consisting of taste, mouthfeel, smoking experience, and combinations thereof. The mouthfeel and / or smoking experience may include saturation, aftertaste, impact, and nicotine kick to replicate smoking a cigarette. The modulation or improvement may be relative to the aerosolized formulation without the combination of one or more sensates, the sweetener, and the emulsifier (e.g., triacetin) compound, wherein at least one sensate is a warming agent or a tingling agent.

[0401] In some embodiments, the use comprises adjusting or improving the flavor of the formulation to replicate smoking a cigarette. In some embodiments, the use comprises adjusting or improving the mouthfeel of the formulation to replicate smoking a cigarette. In some embodiments, the use comprises adjusting or improving saturation to replicate smoking a cigarette. In some embodiments, the use comprises adjusting or improving the aftertaste to replicate smoking a cigarette. In some embodiments, the use comprises adjusting or improving the nicotine kick to replicate smoking a cigarette. In some embodiments, the use comprises adjusting or improving the impact to replicate smoking a cigarette. In some embodiments, the use comprises adjusting or improving the smoking experience to replicate smoking a cigarette. In some embodiments, the use comprises improving the nicotine sensation to replicate smoking a cigarette.

[0402] According to some embodiments, there is provided the use of an emulsifier for adjusting the mouthfeel of an aerosolizable formulation or an aerosol-generating system, the emulsifier having a boiling point of at least about 200° C. at atmospheric pressure, wherein the mouthfeel is adjusted to replicate one or more sensations of smoking a combustible tobacco product, preferably a cigarette. The aerosolizable formulation or aerosol-generating system may be characterized by any of the features defined and discussed herein. The emulsifier function and boiling point of the compound correspond to those discussed above for “compound (iii)” of the consumable. However, the use is not necessarily limited to esters, polyols, or fatty acid esters as defined herein.

[0403] According to some embodiments, there is provided a use of an emulsifier for adjusting the mouthfeel of an aerosolizable formulation or an aerosol generating system, the emulsifier being C4 to C 38 Hydrocarbon esters, C4 to C 38 Hydrocarbyl polyols, or polyoxyalkylene fatty acid esters, wherein the mouthfeel is adjusted to replicate one or more sensations of smoking a combustible tobacco product, preferably a cigarette. The aerosolizable formulation or aerosol generating system may be characterized by any of the features defined and discussed herein. The emulsifier function and chemical properties of the compound correspond to those discussed above for "compound (iii)" of the consumable. However, the use is not necessarily limited to a boiling point of at least about 200°C as defined above.

[0404] These organoleptic properties are defined herein and measured by a trained sensory panel. A trained sensory panel is a group of trained assessors who define the sensory attributes (here, for example, taste, mouthfeel, and / or smoking experience) that best describe the product being evaluated. The trained sensory panel is composed of smokers and / or dual-sample users (i.e., users of cigarettes and electronic cigarettes).

[0405] According to some embodiments, there is provided a use of about 0.0001 to about 5 weight percent of a warming or tingling agent in combination with a sweetener and an emulsifier in a tobacco-flavored aerosolizable formulation or an aerosol-generating system for adjusting the tobacco flavor intensity of a consumable in the formulation or system, wherein the emulsifier compound has a boiling point of at least about 200° C. at atmospheric pressure and / or is C4 to C 38 Hydrocarbon esters, C4 to C 38 Hydrocarbyl polyols, or polyoxyalkylene fatty acid esters. In each of these uses, the aerosolizable formulation or aerosol-generating system may be characterized according to the features defined herein.

[0406] According to some embodiments, there is provided a use of about 0.0001 to about 0.05 weight percent of a warming or tingling agent in combination with a sweetener and triacetin in a tobacco-flavored aerosolizable formulation for adjusting the tobacco flavor intensity of the formulation. According to some embodiments, there is provided a use of about 0.0001 to about 1 weight percent of one or more sensates in combination with a sweetener and triacetin in a tobacco-flavored aerosolizable formulation for adjusting the tobacco flavor intensity of the formulation, wherein at least one sensate is a warming or tingling agent. In each of these uses, the aerosolizable formulation can be characterized according to the features defined herein.

[0407] The invention will now be described with reference to the following non-limiting examples.

[0408] Example

[0409] An investigation was conducted to address the sensory gap between the use of aerosol delivery devices (ie, e-cigarette products) and smoking traditional cigarettes. A baseline aerosolizable formulation was used for comparison and was chosen because of its popularity among smokers in the UK market.

[0410] The sensory focus areas are: flavor, aerosol body / mouthfeel, and smoking experience including sensory saturation, aftertaste, and / or nicotine “hit.” These areas represent consumer-specified differences between aerosol delivery devices and traditional cigarettes.

[0411] The investigation involved the use of sweeteners, flavorings, cooling agents (eg, WS-23), warming / tingling agents, natural oils, menthol, increased water content, and reduced acid content.

[0412] The materials used to prepare the aerosolizable formulations are given in Table 1 below.

[0413] Table 1 - Materials used in aerosolizable formulations

[0414]

[0415] Experiment 1

[0416] Consumables containing the compounds described in Table 1 were prepared in ethanol. In particular, stock solutions of each compound were prepared in ethanol. For the final formulation, certain aliquots of each stock solution were combined and made up to a defined volume to achieve the target concentration. Various formulations were prepared as detailed in Table 2.

[0417] A sensory analysis was then conducted by a trained sensory panel of 10 cigarette users and / or dual users. The panel was selected for their expertise and knowledge of the design and sensory performance of conventional cigarettes. Samples of each formulation were prepared according to the details in Table 2, and the panelists compared the sensory experience of each formulation with that of a tobacco-flavored e-liquid in an aerosol delivery device. The feedback from the trained sensory panel is summarized in Table 2. Weight % values are relative to the total weight of the formulation.

[0418] Table 2

[0419]

[0420]

[0421]

[0422]

[0423] Comparative Examples 1a, 1b, 2a, 2b, and 4 demonstrate how single compounds do not alter a single sensory factor. In contrast, when triacetin and Symheat were independently added to tobacco-flavored e-liquids, multifactorial modulation was observed. Triacetin was unexpectedly found to alter mouthfeel and aerosol body, but without achieving the desired impact or irritation. Symheat (3-phenylpropyl homovanillate) was surprisingly found to alter impact, but undesirably increased aerosol harshness and irritation. Symheat was also reported to alter the location of impact.

[0424] The combination of Symheat and triacetin (Comparative Example 3) is advantageous in some respects, as it increases mouth coating and mouthfeel, and is long-lasting. However, this combination can be problematic for users due to irritation and impact. Panelists reported additional irritation that was "stinging" and left an undesirable "spicy" sensation on the tongue. The combination of neotame and Symheat (Comparative Example 5) made the irritation from Symheat alone more palatable, but the e-liquid left a residual taste.

[0425] Comparative Example 6 investigated the addition of water to tobacco flavored e-liquid, but this resulted in lower flavor intensity and mouthfeel.

[0426] Only the triple combination of triacetin, Symheat, and neotame in Examples 7, 8, 9, and 10 resulted in panelists reporting an "FMC-like" experience. The triple combination was also noteworthy for reported increases in mouthfeel and mouthfullness, as well as a nicotine sensation that lasted long enough to provide the desired aftertaste. Examples 7, 8, 9, and 10 also included feedback that replicated the higher impact and stimulation of smoking a cigarette.

[0427] Experiment 2

[0428] Aerosolizable formulations containing the compounds described in Table 1 were prepared in ethanol in the same manner as in Experiment 1. Specifically, stock solutions of each compound were prepared in ethanol. For the final formulation, aliquots of each stock solution were combined and made up to a defined volume to achieve the target concentration. Various formulations were prepared as detailed in Table 3. Tobacco Flavor 1 and Tobacco Flavor 2 were commercially available e-liquids from Nicoventures Retail (UK) Ltd. Weight % values are relative to the total weight of the formulation.

[0429] Table 3

[0430]

[0431]

[0432] Sensory analysis was conducted by a trained sensory panel of 10 cigarette users and / or dual users (ie, consumers of cigarettes and aerosol delivery devices).

[0433] The panelists compared the sensory experience of each formulation in a VuseGo device, available from Nicoventures Retail (UK) Ltd., with each tobacco-flavored e-liquid alone. These e-liquids were chosen as the benchmark due to consumer preferences in the UK market. Comments from the panelists are shown in Table 4 below.

[0434] Table 4

[0435]

[0436]

[0437] When added to Tobacco Flavor 1, Examples 11, 13, and 15 have different tobacco flavor intensity reports. Example 11 is described as "similar to FMC in terms of feel during puffing," with increased impact and a low "head buzzing" sensation, while Example 13 provides a "medium intensity," and Example 15 has a "light tobacco taste." This varying intensity is advantageous because it allows the formulation to be manipulated according to the desired level of sensation, and smoking product users increasingly desire the ability to customize and control sensations.

[0438] When added to Tobacco Flavor 2, Examples 12, 14, and 16 similarly produced varying tobacco flavor intensities. Example 12 was "close to a Virginia blend cigarette flavor," while Example 14 was "very aromatic" and had a "mild cigarette-like flavor," and Example 16 had a "complex flavor" mixed with a "no smoky or burnt" cigarette flavor. As with Tobacco Flavor 1, this is advantageous because it provides flexibility to formulators and choice to consumers.

[0439] Experiment 3

[0440] To investigate the use of the consumables in aerosolizable formulations in gel form, the gels detailed in Table 5 below were prepared, formed into sticks, and subjected to a product developer test (PDT) in a non-flammable aerosol delivery system to sensory evaluation. All concentrations are in weight percent based on the total weight of the formulation.

[0441] In order to prepare the preparation, the glycerine and adhesive are put into a blender and premixed, and the filler is mixed to form a slurry. The tobacco extract and triacetin (if present) are slowly added to the slurry, and the premix of glycerine and adhesive is added subsequently. The mixture of combination is blended, and the neotame and Symheat solution are added to the final slurry (if present). The preparation is cast in a metal plate and dried to form a gel-like sheet.

[0442] The PDT was performed using an ordinal single-item scale (1-7) to evaluate the sensory performance of the formulations in Table 5 compared to the FMC-like experience. To this end, five participants were asked to evaluate the level of heat puff, immediate smoking satisfaction, off-flavor level, aerosol consistency, overall flavor amplitude, draw force, aerosol body sensation, visible aerosol, irritation level, and impact level of the provided products. The five participants were regular smokers.

[0443] The same apparatus was used for each formulation. The apparatus was a non-flammable aerosol delivery system. Identical instructions were provided to all participants. The only difference between the tests was the formulation tested, and these formulations differed in that they contained consumables according to the present disclosure (and the corresponding filler balance), as shown in Table 5. Formulation 2 included 0.01 wt% neotame and 0.01 wt% Symheat, based on the total weight of the formulation.

[0444] Table 5

[0445]

[0446] The results are shown in Figure 2 and Figure 3 In. Figure 2 In the figure, preparation 1 is the inner picture and preparation 2 is the outer picture. Figure 3 In the figure, preparation 1 is the lower figure and preparation 2 is the upper figure.

[0447] from Figure 2 It can be seen how consumables containing the present disclosure modulate the sensory experience of the aerosolizable formulation, bringing it closer to the FMC experience. In particular, Formulation 2 received higher ratings for immediate puff sensation, aerosol consistency, overall flavor amplitude, aerosol body sensation, visible aerosol, stimulation level, and impact level. The changes in stimulation, impact, and aerosol body are significant and highly beneficial in terms of replicating the FMC experience.

[0448] Figure 3 Shows the Figure 2 The same results, but with absolute values. Once again, it can be seen that formulation 2 has higher ratings in immediate smoking sensation, aerosol consistency, overall flavor amplitude, aerosol body sensation, visible aerosol, irritation level, and impact level. Notably, the impact level increased from 5.8 to 7, the irritation level increased from 5.2 to 7, and the aerosol body increased from 5 to 5.8. These factors are particularly beneficial when attempting to replicate the puffing of a combustible tobacco product such as a cigarette. The present invention will be described in further detail in the following numbered embodiments.

[0449] 1. A consumable product for an aerosolizable formulation, wherein the consumable product comprises:

[0450] one or more sensates, wherein at least one sensate is a warming or tingling agent; a sweetener; and

[0451] Triacetin, optionally wherein the weight ratio of one or more sensates to sweetener is greater than about 1:1 to about 3:1.

[0452] 2. The consumable product of clause 1, wherein the sweetener is selected from the group consisting of oxadiazine sweeteners, aspartame sweeteners, sulfamate, calcium cyclamate, sugar alcohols, naturally occurring sweeteners, saccharin, sucralose, gluconic acid, and mixtures thereof.

[0453] 3. A consumable according to clause 1 or clause 2, wherein the sweetener comprises at least one selected from the group consisting of aspartame sweetener, stevioside, monk fruit extract, glycyrrhizin, perilla sugar, naringin dihydrochalcone, neohesperidin dihydrochalcone, mogroside V, rubusoside, raspberry extract, rebaudioside A, saccharin, sucralose and sodium cyclamate, preferably wherein the sweetener comprises at least one selected from the group consisting of acesulfame-K, aspartame, neotame, saccharin, sucralose or sodium cyclamate, preferably wherein the sweetener is neotame or aspartame.

[0454] 4. The consumable according to any one of clauses 1 to 3, wherein the weight ratio of one or more sensates to sweetener is greater than about 1:1 to about 2:1, preferably wherein the weight ratio is about 2:1.

[0455] 5. A consumable according to any one of clauses 1 to 4, wherein the one or more sensates further comprise a cooling agent, preferably wherein the cooling agent is selected from menthol, N,2,3-trimethyl-2-propan-2-ylbutanamide, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-[(5-methyl-2-propan-2-ylcyclohexanecarbonyl)amino]acetate, N-(4-methoxyphenyl-p-menthanecarboxamide, N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide, menthone 1,2-glycerol ketal, menthyl lactate, 3-(menthoxy)propane-1,2-diol and menthyl succinate.

[0456] 6. The consumable product of any one of clauses 1 to 5, wherein the warming agent or the tingling agent is selected from the group consisting of vanillin, sanshool, piperine, allyl isothiocyanate, cinnamylphenylpropyl compound, ethyl ester, and combinations thereof.

[0457] 7. The consumable product according to clause 6, wherein the warming agent or the tingling agent is a vanillin, preferably 3-phenylpropyl homovanillate.

[0458] 8. The consumable according to any one of clauses 1 to 7, wherein the consumable further comprises one or more compounds selected from the group consisting of 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furfurylthiol, sotolon, 2,4-lutidine, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanol, β-damascone, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide, 3-methylbutanal, acetic acid, 2-methylbutyric acid, 3-methylbutyric acid. Acid, 3-methylvaleric acid, butyric acid, β-damascenone, β-ionone, α-ionone, α-ionol, β-cyclocitral, safranal, maltol, ethyl maltol, 2-methoxyphenol, 4-methyl-2-methoxyphenol, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, phenylacetic acid, methylcyclopentenolone, ethylmethylcyclopentenolone, coronol, mesifurane, maple furanone, benzaldehyde, 4-propyl-2-methoxyphenol, 4-allyl-2,6-dimethoxyphenol, 3-methyl-2,4-nonanedione, 5,6,7-trimethylocta-2,5-dien-4-one, or a combination thereof.

[0459] 9. The consumable product according to clause 8, wherein the at least one compound is selected from the group consisting of compounds A, B, C, D, E and combinations thereof,

[0460] wherein A is at least one compound selected from the group consisting of acetic acid, 2-methylbutyric acid, 3-methylbutyric acid, 3-methylpentanoic acid, and butyric acid, preferably, A is at least one compound selected from the group consisting of acetic acid, 3-methylbutyric acid, and 3-methylpentanoic acid;

[0461] B is at least one compound selected from the group consisting of β-damascone, β-damascenone, β-ionone, α-ionone, α-ionol, β-cyclocitral and safranal. Preferably, B is at least one compound selected from the group consisting of β-damascone, β-damascenone and β-ionone.

[0462] C is at least one compound selected from the group consisting of maltol, ethyl maltol and sotolon, preferably, C is at least one compound selected from the group consisting of maltol and sotolon;

[0463] D is at least one compound selected from the group consisting of 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-dimethoxyphenol, phenylacetic acid, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, methylcyclopentenolone, ethylmethylcyclopentenolone, crotonol, methyfuran, maple furanone, 4-propyl-2-methoxyphenol, benzaldehyde and 4-allyl-2,6-dimethoxyphenol, preferably, D is at least one compound selected from the group consisting of 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-dimethoxyphenol and phenylacetic acid; and

[0464] E is at least one compound selected from the group consisting of 3-methyl-2,4-nonanedione and 5,6,7-trimethylocta-2,5-dien-4-one. Preferably, E is 3-methyl-2,4-nonanedione.

[0465] 10. An aerosolizable formulation for use in an aerosol delivery system, the aerosolizable formulation comprising the consumable product according to any one of clauses 1 to 9, a carrier and optionally nicotine.

[0466] 11. An aerosolizable formulation for an aerosol supply system comprising a consumable according to any one of clauses 1 to 10, wherein the formulation comprises from about 0.001 wt % to about 1 wt % of the one or more sensates, and greater than about 5 wt % to less than about 20 wt % of triacetin.

[0467] 12. An aerosolizable formulation according to clause 12, wherein the formulation comprises a carrier and optionally an active agent, preferably wherein the active agent is nicotine.

[0468] 13. An aerosolizable formulation according to any one of clauses 11 to 13, wherein the carrier is present at about 50 wt% or greater based on the total weight of the formulation, preferably wherein the carrier is present at about 70 wt% or greater based on the total weight of the formulation, preferably wherein the carrier comprises propylene glycol and / or glycerol.

[0469] 14. An aerosolizable formulation according to any one of clauses 11 to 13, wherein the triacetin is present in a concentration of greater than about 10 wt% up to about 18 wt%, preferably greater than about 10 wt% to about 14 wt%.

[0470] 15. An aerosolizable formulation according to any one of clauses 11 to 14, wherein the one or more sensates are present in a concentration of about 0.001 wt% to about 0.5 wt%, about 0.001 wt% to about 0.1 wt%, or about 0.001 wt% to about 0.05 wt%.

[0471] 16. An aerosolizable formulation according to clause 16, wherein the warming or tingling agent is present in a concentration of about 0.001 wt% to about 0.005 wt%, preferably about 0.001 wt% to about 0.0025 wt%.

[0472] 17. An article comprising the aerosolizable formulation according to any one of clauses 11 to 16.

[0473] 18. An article according to clause 17, comprising a reservoir for receiving an aerosolizable formulation according to any one of clauses 11 to 16, an aerosol generating component, an aerosol generating region, a delivery element, and optionally a mouthpiece, preferably wherein the aerosol generating component comprises a heater and / or wherein the delivery element is a wick.

[0474] 19. An aerosol supply system comprising an aerosol supply device and the article according to clause 18.

[0475] 20. A method for forming an aerosol, the method comprising providing an aerosolizable formulation as defined in any one of clauses 11 to 16 and aerosolizing the formulation.

[0476] 21. A sealed container containing the article according to Clause 18, optionally wherein the container is hermetically sealed and formed from a material that inhibits or prevents the passage of ultraviolet light therethrough.

[0477] 22. Use of about 0.001% to about 1% by weight of one or more sensates in combination with a sweetener and triacetin for modifying at least one sensory property of an aerosolizable formulation, wherein at least one sensate is a warming or tingling agent, preferably wherein the aerosolizable formulation is characterized according to the features of any one of clauses 1 to 16.

[0478] 23. The use according to clause 22, wherein the organoleptic properties are selected from taste, mouthfeel and smoking experience and are improved relative to the aerosolizable formulation without the combination of one or more sensates, sweetener and triacetin to replicate smoking a cigarette, at least one sensate being a warming agent or a tingling agent.

[0479] 24. Use of from about 0.001 to about 0.05 weight percent of a warming or tingling agent in combination with a sweetener and triacetin in a tobacco-flavored aerosolizable formulation to adjust the tobacco flavor intensity of the formulation.

[0480] 25. The use according to clause 24, wherein the aerosolizable formulation is characterized according to the features of any one of clauses 1 to 16.

[0481] The various embodiments described herein are only used to help understand and teach the claimed features. These embodiments are provided only as representative samples of embodiments and are not exhaustive and / or exclusive. It should be understood that the advantages, embodiments, examples, functions, features, structures and / or other aspects described herein should not be considered as limitations on the scope of the invention defined by the claims or limitations on the equivalents of the claims, and other embodiments can be used and can be modified without departing from the scope of the claimed invention. The various embodiments of the present invention may suitably include, consist of or essentially consist of the following: appropriate combinations of disclosed elements, components, features, parts, steps, devices, etc., rather than those specifically described herein. In addition, the present disclosure may include other inventions that are not currently claimed but may be claimed in the future.

[0482] Appendix 1

[0483]

[0484]

[0485]

[0486]

Claims

1. A consumable product for an aerosolizable formulation, wherein the consumable product comprises: (i) one or more sensates, wherein at least one sensate is a warming or tingling agent; (ii) sweeteners; and (iii) at least one compound which is an emulsifier and is C4 to C 38 Hydrocarbon esters, C4 to C 38 Hydrocarbyl polyols, or polyoxyalkylene fatty acid esters.

2. The consumable product of claim 1, wherein the at least one compound (iii) has a boiling point of at least about 200°C at atmospheric pressure.

3. The consumable product according to claim 2, wherein the at least one compound (iii) is C4 to C 38 Hydrocarbon ester or C4 to C 38 a hydrocarbon polyol and having a boiling point at atmospheric pressure of at least about 200°C to about 400°C, or wherein the at least one compound (iii) is a polyoxyalkylene fatty acid ester.

4. The consumable product according to any one of the preceding claims, wherein the C4 to C 38 The hydrocarbyl ester is a glyceride.

5. The consumable product according to claim 4, wherein the glyceride is a diglyceride or a triglyceride, preferably a C4 to C 18 diglycerides or triglycerides.

6. The consumable product according to claim 5, wherein the glyceride is a triglyceride, preferably wherein the glyceride is a C4 to C 16 Triglycerides. The consumable product according to claim 6 , wherein the triglyceride is triacetin.

8. The consumable product according to any one of claims 1 to 3, wherein the C4 to C 38 The hydrocarbyl ester is a lactone, preferably a lactone selected from the group consisting of δ-decalactone, γ-decalactone, δ-dodecalactone, γ-dodecalactone, γ-heptadecalactone, ω-6-hexadecene lactone, δ-caprolactone, γ-caprolactone, δ-nonalactone, γ-nonalactone, δ-octalactone, γ-octalactone, ω-pentadecalactone, δ-undecalactone and γ-undecalactone.

9. The consumable product according to any one of claims 1 to 3, wherein the C4 to C 38 Hydrocarbyl esters are C4 to C 38 Hydrocarbyl monoesters or diesters.

10. The consumable product according to claim 10, wherein the C4 to C 38 Hydrocarbon monoesters or diesters are C4 to C 38 Alkyl or alkenyl monoesters or diesters, preferably monoalkyl maleate or dialkyl maleate or monoalkyl fumarate or dialkyl fumarate.

11. The consumable product according to any one of claims 1 to 3, wherein the polyoxyalkylene fatty acid ester is polyoxyethylene sorbitan fatty acid ester.

12. The consumable product according to any one of the preceding claims, wherein the at least one compound (iii) is selected from C4 to C 16 Glycerides, C4 to C 16 Lactone, C8 to C 38 Hydrocarbyl maleate, C8 to C 38 Hydrocarbyl fumarate, C4 to C 38 Hydrocarbyl polyols, and polyoxyethylene fatty acid esters.

13. The consumable product according to claim 13, wherein the at least one compound (iii) is selected from C4 to C 12 Triglycerides, C4 to C 16 Lactone, C 12 to C 34 Hydrocarbyl maleate, C 12 to C 34 Hydrocarbyl fumarate, C4 to C 12 Hydrocarbyl polyols, and polyoxyethylene sorbitan fatty acid esters.

14. A consumable according to any one of the preceding claims, wherein the sweetener is a compound that binds to T1R2 and / or T1R3, or is a compound selected from the group consisting of oxadiazine sweeteners, aspartame sweeteners, sulfamate, calcium cyclamate, sugar alcohols, naturally occurring sweeteners, saccharin, sucralose, gluconic acid, and mixtures thereof.

15. The consumable product of any one of the preceding claims, wherein the sweetener comprises at least one selected from the group consisting of aspartame sweetener, stevioside, monk fruit extract, glycyrrhizin, perilla sugar, naringin dihydrochalcone, neohesperidin dihydrochalcone, mogroside V, rubusoside, Rubus officinalis extract, rebaudioside A, saccharin, sucralose, and sodium cyclamate, preferably wherein the sweetener comprises at least one selected from the group consisting of acesulfame K, aspartame, neotame, saccharin, sucralose, and sodium cyclamate.

16. The consumable product of any preceding claim, wherein the weight ratio of one or more sensates to sweetener is greater than about 1:1 to about 3:1, preferably wherein the weight ratio is greater than about 1:1 to about 2:

1.

17. A consumable according to any one of the preceding claims, wherein the one or more sensates further comprise a cooling agent, preferably wherein the cooling agent is selected from menthol, N,2,3-trimethyl-2-propan-2-ylbutanamide, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-[(5-methyl-2-propan-2-ylcyclohexanecarbonyl)amino]acetate, N-(4-methoxyphenyl-p-menthanecarboxamide, N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide, menthone 1,2-glycerol ketal, menthyl lactate, 3-(menthoxy)propane-1,2-diol and menthyl succinate.

18. The consumable product of any one of the preceding claims, wherein the warming agent or the tingling agent is selected from the group consisting of vanilloids, sanshool, piperine, allyl isothiocyanate, cinnamylphenylpropyl compounds, ethyl esters, and combinations thereof.

19. The consumable product according to claim 18, wherein the warming agent or the tingling agent is a vanillin, preferably 3-phenylpropyl homovanillate, or a combination thereof.

20. The consumable according to any one of the preceding claims, wherein the consumable further comprises one or more compounds (iv) selected from the group consisting of 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furfurylthiol, sotolon, 2,4-lutidine, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanol, β-damascone, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide, 3-methylbutanal, acetic acid, 2-methylbutyric acid, 3- methylbutyric acid, 3-methylvaleric acid, butyric acid, β-damascenone, β-ionone, α-ionone, α-ionol, β-cyclocitral, safranal, maltol, ethyl maltol, 2-methoxyphenol, 4-methyl-2-methoxyphenol, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, phenylacetic acid, methylcyclopentenolone, ethylmethylcyclopentenolone, coronol, mesifurane, maple furanone, benzaldehyde, 4-propyl-2-methoxyphenol, 4-allyl-2,6-dimethoxyphenol, 3-methyl-2,4-nonanedione, 5,6,7-trimethylocta-2,5-dien-4-one, or a combination thereof.

21. The consumable product according to claim 20, wherein the at least one compound (iv) is selected from the group consisting of compounds A, B, C, D, E and combinations thereof, wherein A is at least one compound selected from the group consisting of acetic acid, 2-methylbutyric acid, 3-methylbutyric acid, 3-methylpentanoic acid, and butyric acid, preferably, A is at least one compound selected from the group consisting of acetic acid, 3-methylbutyric acid, and 3-methylpentanoic acid; B is at least one compound selected from the group consisting of β-damascone, β-damascenone, β-ionone, α-ionone, α-ionol, β-cyclocitral and safranal. Preferably, B is at least one compound selected from the group consisting of β-damascone, β-damascenone and β-ionone. C is at least one compound selected from the group consisting of maltol, ethyl maltol and sotolon, preferably, C is at least one compound selected from the group consisting of maltol and sotolon; D is at least one compound selected from the group consisting of 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-dimethoxyphenol, phenylacetic acid, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, methylcyclopentenolone, ethylmethylcyclopentenolone, crotonol, methyfuran, maple furanone, 4-propyl-2-methoxyphenol, benzaldehyde and 4-allyl-2,6-dimethoxyphenol, preferably, D is at least one compound selected from the group consisting of 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-dimethoxyphenol and phenylacetic acid; and E is at least one compound selected from the group consisting of 3-methyl-2,4-nonanedione and 5,6,7-trimethylocta-2,5-dien-4-one. Preferably, E is 3-methyl-2,4-nonanedione.

22. An aerosolizable formulation for use in an aerosol delivery system, the aerosolizable formulation comprising a consumable product according to any preceding claim, a carrier and optionally nicotine.

23. The aerosolizable formulation of claim 22, wherein the carrier is present at about 50 wt% or greater based on the total weight of the formulation, preferably wherein the carrier is present at about 70 wt% or greater based on the total weight of the formulation.

24. An aerosolizable formulation according to claim 22 or claim 23, wherein the carrier comprises propylene glycol, glycerol, water or a combination thereof.

25. An aerosolizable formulation or an aerosol generating system comprising a consumable according to any one of claims 1 to 21, an aerosol former material, one or more binders, and optionally a plant material, preferably wherein the one or more binders consist of one or more gelling agents.

26. An aerosolizable formulation according to any one of claims 22 to 25 or an aerosol generating system according to claim 25, comprising from about 0.0001 wt % to about 5 wt % of the one or more sensates and from about 1 wt % to less than about 35 wt % of the at least one compound (iii), preferably from about 0.0001 wt % to about 3 wt % of the one or more sensates and from about 1 wt % to less than about 30 wt % of the at least one compound (iii).

27. An aerosolizable formulation according to any one of claims 22 to 26 or an aerosol-generating system according to claim 25 or claim 26, wherein the one or more sensates are present in a concentration of about 0.0001 wt% to about 2.5 wt%, about 0.0001 wt% to about 1 wt%.

28. An aerosolizable formulation according to any one of claims 22 to 27 or an aerosol-generating system according to any one of claims 25 to 27, wherein the formulation or system is in the form of a liquid or a gel.

29. An article comprising the aerosolizable formulation according to any one of claims 22 to 28.

30. An article according to claim 29, comprising a reservoir for receiving the aerosolizable formulation according to any one of claims 22 to 28, an aerosol-generating component, an aerosol-generating region, a delivery element, and optionally a mouthpiece, preferably wherein the aerosol-generating component comprises a heater and / or wherein the delivery element is a wick.

31. An aerosol supply system comprising an aerosol supply device and an article according to claim 29 or claim 30, preferably wherein the aerosol supply device is non-flammable.

32. A method for forming an aerosol, the method comprising providing an aerosolizable formulation according to any one of claims 22 to 28, an aerosol generating system according to any one of claims 25 to 28 or an aerosol supply system according to claim 31, and aerosolizing the formulation or consumable in the system.

33. Use of from about 0.0001% to about 5% by weight of one or more sensates in combination with a sweetener and a compound for modulating at least one sensory property of an aerosolizable formulation or an aerosol-generating system, wherein at least one sensate is a warming or tingling agent and the compound is an emulsifier, wherein the compound has a boiling point of at least about 200°C at atmospheric pressure, preferably wherein the aerosolizable formulation is characterized by the features of any one of claims 22 to 28, or wherein the aerosol-generating system is characterized by the features of any one of claims 25 to 28.

34. Use of from about 0.0001% to about 5% by weight of one or more sensates in combination with a sweetener and a compound for modulating at least one sensory characteristic of an aerosolizable formulation or an aerosol generating system, wherein at least one sensate is a warming or tingling agent and the compound is an emulsifier, wherein the compound is C4 to C 38 Hydrocarbon esters, C4 to C 38 A hydrocarbon polyol, or a polyoxyalkylene fatty acid ester, preferably wherein the aerosolizable formulation is characterized by the features of any one of claims 22 to 28, or wherein the aerosol-generating system is characterized by the features of any one of claims 25 to 28.

35. The use of claim 33 or claim 34, wherein the sensory properties are selected from taste, mouthfeel, smoking experience, and combinations thereof, and wherein the sensory properties are altered relative to the aerosolized formulation or the aerosol-generating system without the combination of one or more sensates, the sweetener, and the emulsifier compound, at least one sensate being a warming agent or a tingling agent.

36. The use according to claim 35, wherein the modification of the organoleptic properties provides an aerosolized formulation or an aerosol-generating system that replicates smoking of a combustible tobacco product, preferably a cigarette.

37. Use of an emulsifier having a boiling point of at least about 200°C at atmospheric pressure for modifying the mouthfeel of an aerosolizable formulation or an aerosol-generating system, wherein the mouthfeel is modified to replicate one or more sensations of smoking a combustible tobacco product, preferably a cigarette.

38. Use of an emulsifier for adjusting the mouthfeel of an aerosolizable formulation or an aerosol generating system, the emulsifier being C4 to C 38 Hydrocarbon esters, C4 to C 38 A hydrocarbyl polyol, or a polyoxyalkylene fatty acid ester, wherein the mouthfeel is adjusted to replicate one or more sensations of smoking a combustible tobacco product, preferably a cigarette.

39. Use according to claim 37 or claim 38, wherein the aerosolizable formulation or the aerosol-generating system further comprises at least one sensate and / or sweetener, the at least one sensate being a warming or tingling agent.

40. Use of from about 0.0001 to about 5 weight percent of a warming or tingling agent in combination with a sweetener and a compound in a tobacco flavored aerosolizable formulation or an aerosol generating system for adjusting the tobacco flavor intensity of the formulation or the system, wherein the compound is an emulsifier, wherein the emulsifier compound has a boiling point of at least about 200° C. at atmospheric pressure and / or is C4 to C 38 Hydrocarbon ester or C4 to C 38 A hydrocarbyl polyol, or wherein the emulsifier compound is a polyoxyalkylene fatty acid ester.

41. Use according to any one of claims 37 to 40, wherein the aerosolizable formulation is characterized by the features of any one of claims 22 to 28, or wherein the aerosol-generating system is characterized by the features of any one of claims 25 to 28.

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