Argon-oxygen mixed plasma jet blood coagulation device

Abstract

The invention relates to the technical field of medical instruments, and provides an argon-oxygen mixed plasma jet blood coagulation device which comprises a jet reactor, a power module and a gas supply assembly, the jet reactor comprises a discharge electrode, a medium tube and an insulating shell, and the discharge electrode and the medium tube are arranged in the insulating shell; a connecting end and a jet end are formed at the two ends of the discharge electrode respectively, and the jet end penetrates through the insulating shell and is suitable for forming a plasma jet beam; an air flow channel is formed in at least one of the discharge electrode and the dielectric tube; the power module is connected with the connecting end; the gas supply assembly is connected with the gas flow channel and used for supplying argon-oxygen mixed gas with the preset proportion to the gas flow channel. According to the invention, the thermal damage of tissues can be reduced, so that normal tissues around the wound surface can be protected; in addition, the effect of the biological effect in the blood coagulation process is increased, blood coagulation is accelerated, and the blood coagulation efficiency is remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to an argon-oxygen mixed plasma jet coagulation device. Background Art

[0002] Traditional coagulation techniques primarily use electrosurgical devices (high-frequency electrosurgical units) to stop bleeding. These devices use heat generated by high-frequency current to destroy cells and blood vessels, causing coagulation. However, this method makes it difficult to control the generation and transfer of heat during the coagulation process, which can easily lead to localized overheating and thermal damage to surrounding normal tissue. Furthermore, contact between the high-frequency electrosurgical unit and tissue during coagulation produces carbonization and eschar, as well as adhesion to the blade tip. This can cause bleeding again when the blade leaves the tissue, necessitating repeated coagulation.

[0003] With the increasing demand for refined medical technology, reducing heat loss and thermal damage during coagulation has become a key requirement. Argon plasma coagulation (APC), an emerging coagulation technology, ionizes argon gas by activating electrodes to form an argon plasma, which is then transferred to the target tissue for non-contact coagulation. This solves the problem of eschar and blade adhesion caused by high-frequency electrosurgical units contacting tissue.

[0004] Although argon plasma coagulation can solve the problem of eschar and blade adhesion caused by high-frequency electrosurgery, it uses high-frequency energy (350 kHz) to ionize argon gas and transmit electrical energy to produce thermal coagulation. The high operating temperature of coagulation can cause thermal damage to normal tissues surrounding the wound, leading to complications such as tissue necrosis and inflammatory reactions, and thus affecting the wound healing process. Summary of the Invention

[0005] The present invention provides an argon-oxygen mixed plasma jet coagulation device to solve the above-mentioned technical defects in the prior art. It can not only reduce tissue thermal damage to protect normal tissue around the wound; but also increase the role of biological effects in the coagulation process, accelerate blood coagulation, and significantly improve coagulation efficiency.

[0006] The present invention provides an argon-oxygen mixed plasma jet coagulation device, comprising: A jet reactor comprises a discharge electrode, a dielectric tube, and an insulating shell. The discharge electrode and the dielectric tube are disposed inside the insulating shell. Two ends of the discharge electrode form a connection end and a jet end, respectively. The jet end is disposed through the insulating shell and is suitable for forming a plasma jet beam. An airflow channel is formed inside at least one of the discharge electrode and the dielectric tube. a power module connected to the connection end; The gas supply component is connected to the gas flow channel and is used to supply a preset ratio of argon and oxygen mixed gas to the gas flow channel.

[0007] According to the argon-oxygen mixed plasma jet coagulation device provided by the present invention, the ratio of argon to oxygen is between 9999:1 and 99:1.

[0008] According to the argon-oxygen mixed plasma jet coagulation device provided by the present invention, the dielectric tube is sleeved on the outside of the discharge electrode, and the airflow channel is formed between the dielectric tube and the discharge electrode; The side wall of the insulating shell is provided with an air inlet channel, and the side wall of the medium tube is provided with a branch channel, the branch channel is connected to the air flow channel, the branch channel extends to the position of the air inlet channel and is connected to the air inlet channel; the air inlet channel is connected to the air supply assembly.

[0009] According to the argon-oxygen mixed plasma jet coagulation device provided by the present invention, a hollow tube of a preset length is formed between the connecting end and the jet end of the discharge electrode, the side wall of the hollow tube is provided with an opening, and the air flow channel is connected to the opening.

[0010] According to the argon-oxygen mixed plasma jet coagulation device provided by the present invention, the gas supply assembly includes a first gas pipe, a second gas pipe, and gas sources connected to the first gas pipe and the second gas pipe, the first gas pipe is connected to the first air flow channel, and the second gas pipe is connected to the second air flow channel; The air supply assembly includes a first air pipe, a second air pipe, and air supply sources connected to the first air pipe and the second air pipe. The first air pipe is connected to the first air flow channel, and the second air pipe is connected to the second air flow channel.

[0011] The argon-oxygen mixed plasma jet coagulation device provided by the present invention further includes an adjusting component; The side wall of the insulating shell is provided with an adjustment groove, the adjustment component is provided in the adjustment groove and is connected to the discharge electrode, and the adjustment component is suitable for adjusting the position of the discharge electrode to be close to or away from the target tissue.

[0012] According to the argon-oxygen mixed plasma jet coagulation device provided by the present invention, the insulating shell has a first end and a second end that are oppositely arranged; The first end is provided with a lead channel, the second end is provided with a positioning hole, the connection end of the discharge electrode is passed through the lead channel and connected to the power module; the jet end of the discharge electrode is passed through the positioning hole.

[0013] The argon-oxygen mixed plasma jet coagulation device provided according to the present invention further includes a jet nozzle assembly, which is arranged at the second end of the insulating shell, and the air flow channel is connected to the jet nozzle assembly.

[0014] According to the argon-oxygen mixed plasma jet coagulation device provided by the present invention, the jet nozzle assembly includes: a nozzle component connected to the second end of the insulating housing; The drainage cylinder is rotatably arranged inside the nozzle component, and a through hole is provided inside the drainage cylinder, and the jet end of the discharge electrode is passed through the through hole; the outer circumferential surface of the drainage cylinder is provided with a drainage groove, and the drainage groove is spirally arranged along the axial direction of the drainage cylinder, and the drainage groove is connected to the airflow channel.

[0015] According to the argon-oxygen mixed plasma jet coagulation device provided by the present invention, the power supply module includes a power supply body and a self-calibration impedance matching system. The self-calibration impedance matching system is electrically connected to the power supply body and is used to adjust the power of the power supply body according to the impedance between the argon-oxygen mixed gas and the coagulation load.

[0016] The argon-oxygen mixed plasma jet coagulation device provided by the present invention uses low-power energy output by a power module to provide stable electrical energy for the entire argon-oxygen mixed plasma jet coagulation device. The output energy is regulated to adapt to different coagulation requirements. At the same time, the gas supply component is connected to the air flow channel and is suitable for supplying a preset proportion of argon-oxygen mixed gas to the air flow channel. This arrangement not only reduces heat loss to protect normal tissue around the wound surface, but also increases the role of biological effects in the coagulation process, accelerates blood coagulation, promotes wound healing, and significantly improves coagulation efficiency and shortens coagulation time. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the present invention or the prior art, a brief introduction will be given below to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0018] Figure 1 It is a structural schematic diagram of the argon-oxygen mixed plasma jet coagulation device provided in Example 1 of the present invention.

[0019] Figure 2 It is a structural schematic diagram of the argon-oxygen mixed plasma jet coagulation device provided in the second embodiment of the present invention.

[0020] Figure 3 yes Figure 2The schematic diagram of the structural decomposition of the jet nozzle assembly in the argon-oxygen mixed plasma jet coagulation device is shown.

[0021] Figure 4 It is a structural schematic diagram of the argon-oxygen mixed plasma jet coagulation device provided in Example 3 of the present invention.

[0022] Figure 5 yes Figure 4 The schematic diagram of the structural decomposition of the argon-oxygen mixed plasma jet coagulation device is shown.

[0023] Figure 6 yes Figure 4 An axonometric cross-sectional view of an argon-oxygen mixed plasma jet coagulation device is shown.

[0024] Figure 7 This is a schematic diagram of the use status of the argon-oxygen mixed plasma jet coagulation device provided by an embodiment of the present invention.

[0025] Figure 8 This is an equivalent circuit diagram of the argon-oxygen mixed plasma jet coagulation device provided in an embodiment of the present invention.

[0026] Figure 9 (a) shows the relative intensity of the spectrum of active particles measured by the spectrometer of the argon plasma condensation equipment.

[0027] FIG9( b ) shows the relative intensity of the spectrum of active particles measured by the spectrometer of the argon-oxygen mixed plasma jet coagulation device.

[0028] Figure 10(a) is a comparison of the coagulation rates of different devices during partial liver resection in pigs.

[0029] Figure 10(b) is a temperature comparison diagram of different devices during partial liver resection in pigs.

[0030] Figure 11 Schematic diagram comparing the processing of different devices during partial liver resection in pigs. 10. Jet reactor; 11. Discharge electrode; 111. Connecting end; 112. Jet end; 12. Dielectric tube; 121. Branch channel; 13. Insulating housing; 131. Inlet channel; 132. Positioning hole; 133. Lead channel; 134. Adjustment slot; 141. First airflow channel; 142. Second airflow channel; 20. Power module; 30. Air supply assembly; 31. First air supply pipe; 32. Second air supply pipe; 40. Adjustment components; 50. Jet nozzle assembly; 51. Nozzle component; 52. Drainage cylinder; 521. Drainage trough. DETAILED DESCRIPTION

[0031] To make the objectives, technical solutions, and advantages of the present invention more clear, the technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts shall fall within the scope of protection of the present invention.

[0032] In the description of the embodiments of this application, it should be noted that, unless otherwise specified or limited, the terms "connected" and "connection" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium. Those skilled in the art will understand the specific meanings of the above terms in the embodiments of this application based on the specific circumstances.

[0033] In the embodiments of the present application, unless otherwise expressly specified or limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Furthermore, a first feature being "above," "above," and "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below," "below," and "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0034] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the embodiments of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification and the features of different embodiments or examples, unless they are contradictory.

[0035] An embodiment of the present invention provides an argon-oxygen mixed plasma jet coagulation device, comprising a jet reactor 10 , a power module 20 and a gas supply assembly 30 .

[0036] The jet reactor 10 includes a discharge electrode 11, a dielectric tube 12, and an insulating housing 13. The discharge electrode 11 and the dielectric tube 12 are disposed within the insulating housing 13. The discharge electrode 11 has a connection end 111 and a jet end 112 at either end, respectively. The jet end 112 extends through the insulating housing 13 and is suitable for forming a plasma jet beam. An airflow channel 14 is formed within at least one of the discharge electrode 11 and the dielectric tube 12. This channel 14 can be formed in the discharge electrode 11, the dielectric tube 12, or both. The channel 14 provides a flow path for the working gas.

[0037] The power module 20 serves as the energy supply core of the argon-oxygen plasma jet coagulation device and is connected to the connection terminal 111 of the discharge electrode 11. The power module 20 provides stable power to the entire argon-oxygen plasma jet coagulation device. The output energy (30 kHz to 50 kHz) is regulated by a self-calibrating impedance matching system to adapt to different coagulation requirements.

[0038] The power module 20 has a voltage of 90V-110V and a pulse width of 7μs-10μs. It includes a power supply and a self-calibrating impedance matching system electrically connected to the power supply for adjusting the power of the power supply based on the impedance between the argon-oxygen mixture and the coagulation load.

[0039] The self-calibrating impedance matching system primarily consists of an impedance matching network (adjustable element) and a main control module (self-calibrating controller). The main control module provides feedback and control. The input of the impedance matching network (adjustable element) is connected to the output of the power supply, and the output of the impedance matching network (adjustable element) is connected to the load. The main control module is electrically connected to the impedance matching network (adjustable element) and measures the system's input and output power in real time, providing a reference for impedance matching. By monitoring power changes, the system can adjust matching parameters in a timely manner to ensure optimal operating conditions. In other words, the self-calibrating impedance matching system can assess coagulation effectiveness based on load impedance and proactively reduce output power when coagulation is nearly complete, minimizing thermal damage.

[0040] The main control module, serving as the system's core controller, receives signals from the power monitoring circuit, processes and analyzes the data, calculates the parameters required for optimal impedance matching, and sends these parameters to the . Based on the power information provided by the power monitoring circuit, the main control module calculates and determines the required impedance matching parameters. In other words, the main control module processes the data collected by the power monitoring circuit in real time, calculates the load impedance modulus, determines the degree of mismatch between the current load impedance and the target impedance, and then issues a signal for adjustment.

[0041] The gas supply assembly 30 is connected to the airflow channel 14 and is configured to supply a preset ratio of argon and oxygen mixed gas to the airflow channel 14. The structure of the gas supply assembly 30 corresponds to the arrangement of the airflow channel 14. For example, when the airflow channel 14 is arranged as a single channel, the gas supply assembly 30 is connected to the airflow channel 14 and is suitable for supplying a preset ratio of argon and oxygen mixed gas to the airflow channel 14. When the airflow channel 14 is arranged as a dual channel, the gas supply assembly 30 includes different gas pipes, each gas pipe being configured to supply gas to the connected airflow channel 14.

[0042] Figure 1 It is a structural schematic diagram of the argon-oxygen mixed plasma jet coagulation device provided in Example 1 of the present invention.

[0043] See Figure 1 In a first embodiment of the present invention, an argon-oxygen mixed plasma jet coagulation device is provided, wherein a jet reactor 10 includes a discharge electrode 11, a dielectric tube 12 and an insulating shell 13. The dielectric tube 12 is sleeved on the outside of the discharge electrode 11, and an air flow channel 14 is formed between the dielectric tube 12 and the discharge electrode 11.

[0044] The jet reactor 10 comprises a discharge electrode 11, a dielectric tube 12, and an insulating housing 13, nested from inside to outside. Specifically, the discharge electrode 11 is embedded within the dielectric tube 12, coaxially arranged with the dielectric tube 12. The discharge electrode 11 has a connecting end 111 and a jet end 112 at either end, respectively. The jet end 112 is adapted to form a plasma jet beam. An airflow channel 14 is formed between the dielectric tube 12 and the discharge electrode 11. The discharge electrode 11 can be tubular, needle-shaped, rod-shaped, or blade-shaped. Discharge electrodes 11 of different shapes have different discharge parameters and forms, and accordingly, different coagulation efficiencies.

[0045] An air inlet channel 131 is provided on the side wall of the insulating shell 13, and a branch channel 121 is provided on the side wall of the medium tube 12. The branch channel 121 is connected to the air flow channel 14. The branch channel 121 extends to the position of the air inlet channel 131 and is connected to the air inlet channel 131; the air inlet channel 131 is connected to the air supply component.

[0046] Equivalently, the working gas supplied by the gas supply component is input from the air inlet channel 131, and the working gas is transported along the air flow channel 14 to the jet end 112 of the discharge electrode 11, ionized to form a plasma jet beam, and transmitted to the target tissue for rapid coagulation.

[0047] The gas supply assembly is connected to the airflow channel 14 and is adapted to supply a preset ratio of argon-oxygen mixed gas to the airflow channel 14. The preset ratio of the argon-oxygen mixed gas is between 9999:1 and 99:1. This means that the oxygen content of the argon-oxygen mixed gas is between 0.01% and 1%. Preferably, the oxygen content of the argon-oxygen mixed gas is 0.05%.

[0048] Among them, the gas supply assembly includes a gas source and a corresponding gas pipe. The gas source includes argon and oxygen gas sources, such as argon cylinders and oxygen cylinders, or a gas generation system consisting of an oxygen concentrator and an argon generator to provide a stable supply of argon and oxygen.

[0049] The gas supply assembly may also include a gas mixing device. The gas mixing device adopts a high-precision gas mixer that can accurately control the flow and ratio of argon and oxygen to ensure that the output argon-oxygen mixed gas ratio meets the preset requirements.

[0050] The gas supply assembly may further include a pressure regulating device, which is equipped with a pressure sensor and a regulating valve, and automatically adjusts the gas supply pressure according to the pressure changes in the gas flow channel 14 to ensure a stable supply of gas.

[0051] The gas supply assembly may also include a flow monitoring and control device, using equipment such as a mass flow controller to monitor and control the flow of argon and oxygen in real time to ensure that the ratio and flow of the mixed gas are accurate and stable.

[0052] In an embodiment of the present invention, the power module 20 is generated by RLC resonance. When the circuit operates at the resonant frequency point, the output power is maximum. The resonant frequency point is jointly determined by the internal parameters of the power module and the load impedance parameters. The internal parameters of the power module 20 are adjusted to be able to resonate with the tissue equivalent impedance parameters in the non-coagulated state, so that the power module can output maximum power for the wound in the non-coagulated state. When the blood gradually coagulates, the tissue equivalent circuit parameters change, and the circuit operating point deviates from the resonant point. At this time, the output power decreases, reducing thermal damage to the tissue. The power change of the power module is adaptively adjusted through the change of the impedance of the power module-electrode-human biological tissue loop.

[0053] It is understood that the argon-oxygen mixed plasma jet coagulation device provided in an embodiment of the present invention uses the low-power energy output by the power module 20 to provide stable electrical energy for the entire argon-oxygen mixed plasma jet coagulation device. The output energy (30 kHz-50 kHz) is regulated by a self-calibration impedance matching system to adapt to different coagulation requirements. At the same time, the gas supply component is connected to the airflow channel 14 and is suitable for supplying a preset ratio of argon-oxygen mixed gas to the airflow channel 14. This arrangement not only reduces heat loss to protect normal tissue around the wound surface, but also increases the role of biological effects in the coagulation process, accelerates blood coagulation, promotes wound healing, and significantly improves coagulation efficiency and shortens coagulation time.

[0054] Compared to traditional argon plasma coagulation, which uses high-frequency energy (350 kHz) to ionize argon and transfer electrical energy to produce thermal coagulation, the power module 20 in this embodiment uses lower output energy to minimize thermal damage to tissue and protect normal tissue surrounding the wound. Simultaneously, an argon-oxygen mixture is added to form a plasma jet in the jet reactor 10. The presence of oxygen contributes to the production of more reactive nitrogen oxides (RONS). These RNOs have multiple biological effects, such as accelerating blood coagulation and promoting wound healing. They can significantly improve coagulation efficiency, shorten clotting time, and reduce wound bleeding.

[0055] The power module 20 is connected to the discharge electrode 11 via a self-calibrating impedance matching system. This system adaptively adjusts the output power based on changes in the wound surface (such as impedance changes during blood coagulation). As the blood gradually coagulates and the wound surface becomes solid or eschar, the impedance mismatch creates, and the system reduces the output power. This adaptive power regulation mechanism avoids excessive energy input, thereby reducing thermal damage and protecting surrounding normal tissue.

[0056] At the same time, the power module 20 provides a stable energy source for the device. Its fixed-frequency characteristic stabilizes the output frequency of the power module 20, contributing to the stable generation of the plasma jet. Compared to variable-frequency power supplies, fixed-frequency power supplies have a simpler circuit structure and higher reliability, reducing the possibility of device failures caused by power frequency fluctuations.

[0057] In some embodiments of the present invention, the tributary channel 121 is provided at a position of the medium tube 12 close to the connection end 111 , and the position of the air inlet channel 131 corresponds to the position of the tributary channel 121 .

[0058] In some embodiments of the present invention, a hollow tube of a preset length is formed between the connecting end 111 and the jet end 112 of the discharge electrode 11 . The side wall of the hollow tube is provided with an opening, and the air flow channel 14 is connected to the opening.

[0059] In other words, the discharge electrode 11 provided in this embodiment of the present invention is a hollow electrode with an opening provided on its sidewall. This opening is connected to the airflow channel 14. The working gas flows not only along the airflow channel 14 outside the discharge electrode 11 but also along the hollow cavity inside the discharge electrode 11. This combined ventilation inside and outside the discharge electrode 11 increases the working gas's active area, improves the concentration of plasma active species per unit volume, and enhances the coagulation rate.

[0060] The discharge electrode 11 may be a stainless steel hollow tube, the side of which may be opened as a gas passage, and the distance between the discharge electrode 11 and the tube opening of the dielectric tube 12 may be 13 mm.

[0061] The dielectric tube 12 may be a glass tube, and the insulating shell 13 may be made of materials such as ABS (acrylonitrile-butadiene-styrene copolymer), PC (polycarbonate), and PP (polypropylene).

[0062] Continue reading Figure 1 In some embodiments of the present invention, the insulating shell 13 has a first end and a second end that are arranged opposite to each other; the first end is provided with a lead channel 133, and the second end is provided with a positioning hole 132, the connection end 111 of the discharge electrode 11 is passed through the lead channel 133 and is connected to the self-calibration impedance matching system; at least one of the jet end 112 of the discharge electrode 11 and the dielectric tube 12 is passed through the positioning hole 132.

[0063] In the argon-oxygen plasma jet coagulation device, the arrangement of the insulating housing 13 and the discharge electrode 11 ensures precise control and safe operation of the plasma jet. By adjusting the position of the discharge electrode 11, precise control of the coagulation process can be achieved, reducing damage to surrounding tissue.

[0064] Continue reading Figure 1 In some embodiments of the present invention, the insulating shell 13 includes a first shell 135 and a second shell 136, and the first shell 135 and the second shell 136 are detachably connected; the lead channel 133 is provided at the end of the first shell 135, and the positioning hole 132 is provided at the end of the second shell 136.

[0065] Figure 2 It is a structural schematic diagram of the argon-oxygen mixed plasma jet coagulation device provided in the second embodiment of the present invention. Figure 3 yes Figure 2 The schematic diagram of the structural decomposition of the jet nozzle assembly in the argon-oxygen mixed plasma jet coagulation device is shown.

[0066] See Figure 2 and Figure 3 In some embodiments of the present invention, the argon-oxygen mixed plasma jet coagulation device further includes a jet nozzle assembly 50, which is disposed at the second end of the insulating shell 13, and the air flow channel 14 is connected to the jet nozzle assembly 50 to disperse the plasma jet beam.

[0067] By spreading the plasma jet beam and applying it more evenly to the wound, the coagulation efficiency of the wound can be improved. At the same time, the wind speed can be used to cool the wound, further reducing thermal damage.

[0068] Specifically, the jet nozzle assembly 50 includes a nozzle component 51 and a drainage cylinder 52, the nozzle component 51 is connected to the second end of the insulating shell 13; the drainage cylinder 52 is rotatably arranged inside the nozzle component 51, and a through hole is provided inside the drainage cylinder 52, and the jet end 112 of the discharge electrode 11 is passed through the through hole; the outer circumferential surface of the drainage cylinder 52 is provided with a drainage groove 521, and the drainage groove 521 is spirally arranged along the axial direction of the drainage cylinder 52, and the drainage groove 521 is connected to the airflow channel 14.

[0069] The nozzle assembly 51 can be made of a high-temperature, corrosion-resistant ceramic material with excellent insulation properties and mechanical strength. The nozzle assembly 51 has an overall conical shape and can be securely connected to the second end of the insulating housing 13 via a threaded connection. The connection is sealed with sealant to prevent gas leakage. An annular groove is provided within the nozzle assembly 51 to position and secure the drainage cylinder 52.

[0070] The nozzle assembly 51 can be a single piece or comprised of multiple components. Its primary function is to connect the airflow channel 14 and the gas mixing chamber. The insulating housing 13 is a split-piece design. During assembly, the nozzle assembly 51 can be clamped between the insulating housing 13 to achieve securement. Glue or other auxiliary materials can also be used for securing.

[0071] When the argon-oxygen mixture flows from the airflow channel 14 into the drainage groove 521, the spiral airflow surrounds the jet end 112 of the discharge electrode 11. When the jet end 112 of the discharge electrode 11 generates a plasma jet, the spiral airflow constrains and guides the plasma jet, making it more concentrated and stable. At the same time, the plasma jet beam spreads out, acting more evenly on the wound surface, thereby improving the coagulation efficiency of the wound.

[0072] Figure 4 It is a structural schematic diagram of the argon-oxygen mixed plasma jet coagulation device provided in Example 3 of the present invention. Figure 5 yes Figure 4 The schematic diagram of the structural decomposition of the argon-oxygen mixed plasma jet coagulation device is shown. Figure 6 yes Figure 4 An axonometric cross-sectional view of an argon-oxygen mixed plasma jet coagulation device is shown.

[0073] See Figures 4 to 6In the argon-oxygen mixed plasma jet coagulation device provided in the third embodiment of the present invention, the jet reactor 10 includes a discharge electrode 11, a dielectric tube 12 and an insulating shell 13. The dielectric tube 12 and the discharge electrode 11 are arranged side by side inside the insulating shell 13. The interior of the dielectric tube 12 constructs a first air flow channel 141, and the interior of the discharge electrode 11 constructs a second air flow channel 142; the two ends of the discharge electrode 11 respectively form a connecting end 111 and a jet end 112, and the jet end 112 is suitable for forming a plasma jet beam.

[0074] The gas supply component 30 is respectively connected to the first air flow channel 141 and the second air flow channel 142, wherein one of the first air flow channel 141 and the second air flow channel 142 can transport argon, and the other of the first air flow channel 141 and the second air flow channel 142 can transport oxygen, which is equivalent to the first air flow channel 141 and the second air flow channel 142 can transport different gases. Of course, the first air flow channel 141 and the second air flow channel 142 can also transport the same gas.

[0075] When it is necessary to utilize the different characteristics of argon and oxygen for plasma jet coagulation, the first gas pipe 31 and the second gas pipe 32 supply different working gases. The first gas pipe 31 can supply argon, and the second gas pipe 32 supplies oxygen. For example, the first gas pipe 31 delivers argon with a purity of 99.99% to the first air flow channel 141 at a flow rate of 5 L / min through the gas supply source. The second gas pipe 32 delivers oxygen with a purity of 99.5% to the second air flow channel 142 at a flow rate of 3 L / min. The use of mixed gases, especially mixed oxygen, is mainly to achieve the production of a high concentration of reactive oxygen species at relatively low power, while reducing thermal damage without reducing the coagulation effect.

[0076] In the generating chamber of the jet reactor 10 , argon and oxygen flow in according to their respective gas flow channels, and the two gases can be fully mixed and form an argon-oxygen mixed plasma jet under the action of a high-frequency electric field.

[0077] When the argon supply needs to be increased to enhance the plasma jet, both the first gas pipe 31 and the second gas pipe 32 supply argon. For example, the first gas pipe 31 can simultaneously deliver argon at a flow rate of 6 L / min, while the second gas pipe 32 can deliver argon at a flow rate of 4 L / min. This allows more argon to enter the generator chamber of the jet reactor 10, resulting in a higher energy density in the generated argon plasma jet. This may enable more rapid denaturation and coagulation of blood proteins during the coagulation process while reducing thermal damage to surrounding tissues.

[0078] It should be noted that the gas supply assembly 30 may also include a pressure regulating device, which is equipped with a pressure sensor and a regulating valve to automatically adjust the gas supply pressure according to the pressure changes in the corresponding air flow channel to ensure a stable supply of gas.

[0079] The gas supply assembly 30 may also include a flow monitoring and control device, using a mass flow controller and other equipment to monitor and control the flow of argon and oxygen in real time to ensure that the ratio and flow of the mixed gas are accurate and stable.

[0080] It is understood that the argon-oxygen mixed plasma jet coagulation device provided in an embodiment of the present invention uses the low-power energy output by the power module 20 to provide stable electrical energy for the entire argon-oxygen mixed plasma jet coagulation device. The output energy (30 kHz-50 kHz) is regulated by a self-calibration impedance matching system to adapt to different coagulation requirements. At the same time, the gas supply component 30 is connected to the air flow channel 14 and is suitable for supplying a preset ratio of argon-oxygen mixed gas to the air flow channel 14. This arrangement not only reduces heat loss to protect normal tissue around the wound surface, but also increases the role of biological effects in the coagulation process, accelerates blood coagulation, promotes wound healing, and significantly improves coagulation efficiency and shortens coagulation time.

[0081] Compared to traditional argon plasma coagulation, which uses high-frequency energy (350 kHz) to ionize argon and transfer electrical energy to produce thermal coagulation, the power module 20 in this embodiment uses lower output energy, minimizing thermal damage to tissue and protecting normal tissue surrounding the wound. Simultaneously, an argon-oxygen mixture is added to form a plasma jet in the jet reactor 10. The presence of oxygen contributes to the production of more reactive nitrogen oxides (RONS). These RNOs have various biological effects, such as accelerating blood coagulation and promoting wound healing. They can significantly improve coagulation efficiency, shorten clotting time, and reduce wound bleeding.

[0082] The power module 20 is connected to the discharge electrode 11 after being adjusted using a self-calibrating impedance matching system. This system adaptively adjusts the output power based on changes in the wound surface (such as impedance changes during blood coagulation). As the blood gradually coagulates and the wound surface becomes solid or eschar, the impedance mismatch creates, and the system reduces the output power. This adaptive power adjustment mechanism avoids excessive energy input, thereby reducing thermal damage and protecting surrounding normal tissue.

[0083] In some embodiments of the present invention, a hollow tube of a preset length is formed between the connection end 111 and the jet end 112 of the discharge electrode 11. This means that the discharge electrode 11 provided in the embodiment of the present invention is a hollow electrode.

[0084] The front end of the discharge electrode 11 can be solid and have a specific shape, such as a needle or knife shape. The middle and rear ends of the discharge electrode 11 can be stainless steel hollow tubes, the sides of which can be opened to serve as gas passages. The distance between the discharge electrode 11 and the opening of the dielectric tube 12 can be 13 mm.

[0085] The dielectric tube 12 may be a glass tube, and the insulating shell 13 may be made of materials such as ABS (acrylonitrile-butadiene-styrene copolymer), PC (polycarbonate), and PP (polypropylene).

[0086] Continue reading Figures 4 to 6 In some embodiments of the present invention, the air supply assembly 30 includes a first air pipe 31, a second air pipe 32, and an air supply source connected to the first air pipe 31 and the second air pipe 32, the first air pipe 31 is connected to the first air flow channel 141, and the second air pipe 32 is connected to the second air flow channel 142.

[0087] In other words, the argon-oxygen mixed plasma jet coagulation device has two air inlet pipes, namely, a first air supply pipe 31 and a first air flow channel 141 connected to the first air supply pipe 31, and a second air supply pipe 32 and a second air flow channel 142 connected to the second air supply pipe 32. The first air supply pipe 31 and the second air supply pipe 32 can supply different working gases or the same working gas.

[0088] The gas supply assembly 30 is further provided with a gas flow regulating valve and a pressure sensor. The gas flow regulating valve can control the gas flow entering the first gas pipe 31 and the second gas pipe 32. The pressure sensor is used to monitor the gas pressure in the first gas pipe 31 and the second gas pipe 32 in real time.

[0089] Continue reading Figures 4 to 6 In some embodiments of the present invention, the argon-oxygen mixed plasma jet coagulation device further includes an adjusting component 40; an adjusting groove 134 is provided on the side wall of the insulating shell 13, and the adjusting component 40 is provided in the adjusting groove 134 and connected to the discharge electrode 11. The adjusting component 40 is suitable for adjusting the position of the discharge electrode 11 to be close to or away from the target tissue.

[0090] Since different tissue depths may require different positions of the discharge electrode 11 during the coagulation operation, the discharge electrode 11 can be adjusted to a suitable position according to the depth of the tissue and the coagulation requirements by means of the adjustment component 40 to ensure the optimization of the coagulation effect.

[0091] The adjustment component 40 may consist of a slider and a connecting rod. The slider is located on the outer wall of the insulating housing 13 for easy manual operation. One end of the connecting rod is connected to the slider, while the other end of the connecting rod passes through the adjustment slot 134 and connects to the discharge electrode 11. By pushing the slider within the adjustment slot 134, the position of the discharge electrode 11 can be adjusted.

[0092] Continue reading Figures 4 to 6 In some embodiments of the present invention, the insulating shell 13 has a first end and a second end arranged opposite to each other; the first end is provided with a lead channel 133, and the second end is provided with a positioning hole 132, the connection end 111 of the discharge electrode 11 is passed through the lead channel 133 and is connected to the self-calibration impedance matching system; the jet end 112 of the discharge electrode 11 is passed through the positioning hole 132.

[0093] The lead channel 133 is a circular hole with a diameter designed according to the size of the connection end 111 of the discharge electrode 11. The inner wall of the channel is smooth to reduce wear on the discharge electrode 11. The positioning hole 132 can be a circular or square hole. The shape of the positioning hole 132 can also be other shapes, mainly determined by the shape of the jet end 112 of the discharge electrode 11. Its size is slightly larger than the diameter of the jet end 112 of the discharge electrode 11 to facilitate installation and positioning of the discharge electrode 11.

[0094] In the argon-oxygen plasma jet coagulation device, the arrangement of the insulating housing 13 and the discharge electrode 11 ensures precise control and safe operation of the plasma jet. By adjusting the position of the discharge electrode 11, precise control of the coagulation process can be achieved, reducing damage to surrounding tissue.

[0095] Continue reading Figures 4 to 6 In some embodiments of the present invention, the argon-oxygen mixed plasma jet coagulation device further includes a jet nozzle assembly 50, which is disposed at the second end of the insulating shell 13, and the air flow channel 14 is connected to the jet nozzle assembly 50 to disperse the plasma jet beam.

[0096] By dispersing the plasma jet beam and applying it more evenly to the wound, the coagulation efficiency of the wound can be improved. At the same time, the wind speed can be adjusted to cool the wound and further reduce thermal damage.

[0097] Specifically, the jet nozzle assembly 50 includes a nozzle component 51 and a drainage cylinder 52, the nozzle component 51 is connected to the second end of the insulating shell 13; the drainage cylinder 52 is rotatably arranged inside the nozzle component 51, and a through hole is provided inside the drainage cylinder 52, and the jet end 112 of the discharge electrode 11 is passed through the through hole; the outer circumferential surface of the drainage cylinder 52 is provided with a drainage groove 521, and the drainage groove 521 is spirally arranged along the axial direction of the drainage cylinder 52, and the drainage groove 521 is connected to the airflow channel 14.

[0098] The nozzle component 51 can be made of a ceramic material that is resistant to high temperatures and corrosion, and has good insulation performance and mechanical strength. The overall shape of the nozzle component 51 is conical, and it can be firmly connected to the second end of the insulating housing 13 by means of threaded connection or other connection methods. A sealant is used at the connection to prevent gas leakage. An annular card slot is provided inside the nozzle component 51, and the annular card slot is used to position and fix the drainage cylinder 52.

[0099] The nozzle component 51 can be an integral structure or composed of multiple components. The main function of the nozzle component 51 is to connect the air flow channel 14 and the gas mixing chamber. The insulating housing 13 is a split design. During the assembly process, the nozzle component 51 can be clamped between the insulating housing 13 to achieve fixation, and glue and the like can also be used for assistance in fixation.

[0100] When the argon-oxygen mixed gas flows from the air flow channel 14 into the drainage groove 521, the spiral air flow will surround the jet end 112 of the discharge electrode 11. When the jet end 112 of the discharge electrode 11 generates a plasma jet, the spiral air flow will have a constraining and guiding effect on the plasma jet, making the plasma jet more concentrated and stable; at the same time, the plasma jet beam spreads out and acts on the wound surface more evenly, which can improve the blood coagulation efficiency of the wound surface.

[0101] Figure 7 is a schematic diagram of the usage state of the argon-oxygen mixed plasma jet blood coagulation device provided by an embodiment of the present invention. Figure 8 is an equivalent circuit diagram in the argon-oxygen mixed plasma jet blood coagulation device provided by an embodiment of the present invention.

[0102] Refer to Figure 7 , the argon-oxygen mixed plasma jet blood coagulation device provided by an embodiment of the present invention has an adaptive blood coagulation function for the blood coagulation part, which is based on the impedance self-matching principle between the argon-oxygen mixed gas jet of the argon-oxygen mixed plasma jet blood coagulation device and the blood coagulation load.

[0103] Among them, the plasma generated by the argon-oxygen mixed gas jet contacts the blood coagulation site, and the blood at the blood coagulation site is quickly oxidized and coagulated to form a blood film substance with a slightly darker color, and the equivalent impedance parameter presented is Rh2. The equivalent impedance of the tissue at the non-blood coagulation site is Rh1, and there is Rh1 < Rh2. The equivalent current path is as Figure 8 shown. Even under the condition that the jet treatment position remains unchanged, due to the smaller Rh1 impedance, it will automatically share more of the current component of the Ar jet, thereby promoting the rapid blood coagulation and oxidation of the non-blood coagulation position to form a blood film and increasing the impedance value of Rh1 until the Rh1 and Rh2 impedances are approximately equal, completing the blood coagulation function of the entire blood coagulation site.

[0104] Continue to refer to Figure 7During plasma argon-oxygen jet treatment, the degree of coagulation changes with increasing treatment time. The degree of coagulation is intuitively reflected by the color of the blood, and this change in state can be manifested as a difference in impedance (Rh1, Rh2). Specifically, as treatment time increases, the darker the blood color (higher the degree of coagulation), the greater the impedance. When the resistance of Rh2 (blood color) increases, the plasma current path adaptively adjusts, creating a diversion. This allows the plasma jet to automatically optimize energy distribution based on real-time impedance changes, thereby achieving continuous control of the coagulation process.

[0105] In an embodiment of the present invention, the power module 20 is generated by RLC resonance. When the circuit operates at the resonant frequency point, the output power is maximum. The resonant frequency point is jointly determined by the internal parameters of the power module and the load impedance parameters. The internal parameters of the power module 20 are adjusted to be able to resonate with the tissue equivalent impedance parameters in the non-coagulated state, so that the power module 20 can output the maximum power for the wound in the non-coagulated state. When the blood gradually coagulates, the tissue equivalent circuit parameters change, and the circuit operating point deviates from the resonant point. At this time, the output power decreases, reducing thermal damage to the tissue. The power change of the power module 20 is adaptively adjusted by changing the impedance of the power supply-electrode-human biological tissue loop.

[0106] Figure 9(a) shows the relative intensity of the spectrum of active particles measured by the spectrometer of the argon plasma coagulation device. Figure 9(b) shows the relative intensity of the spectrum of active particles measured by the spectrometer of the argon-oxygen mixed plasma jet coagulation device.

[0107] In the embodiment of the present invention, a pig in vivo partial liver resection model is used to simulate clinical partial liver resection, and conventional argon plasma coagulation equipment and argon-oxygen mixed plasma jet device are used to treat the bleeding section of the liver.

[0108] During the test, the coagulation rate and the maximum working temperature were recorded.

[0109] Referring to Figures 9(a) and 9(b), the relative intensity of the spectra of active particles was measured by a spectrometer. The results show that the spectral emission intensity of the reactive nitrogen oxides (RONS) species, i.e., [OH(AX)], [O](777), etc., produced by the argon plasma condensation device is lower than that of the RONS species produced by the argon-oxygen mixed plasma jet device.

[0110] Figure 10(a) is a graph comparing the coagulation rates of different devices during partial liver resection in pigs. Figure 10(b) is a graph comparing the temperatures of different devices during partial liver resection in pigs.

[0111] Refer to Figure 10(a), during the partial liver resection in pigs, the average coagulation rate of the argon-oxygen mixed plasma jet device was 0.078s / cm 2 The average coagulation rate of the argon plasma coagulation equipment is 0.096s / cm 2 .

[0112] Referring to Figure 10(b), during the partial liver resection in a pig, the maximum operating temperature of the argon-oxygen mixed plasma jet device during the coagulation process was 91.3°C; the maximum operating temperature of the argon plasma coagulation device during the coagulation process was 117.3°C.

[0113] Figure 11 Schematic diagram comparing the processing of different devices during partial liver resection in pigs.

[0114] See Figure 11 The degree of thermal injury was assessed by hematoxylin-eosin staining after single-point treatment 1 cm from the liver surface for 5s, 10s, and 20s using an argon-oxygen mixed plasma jet device and an argon plasma coagulation device.

[0115] The liver's thermal damage area showed three distinct boundaries: the carbonization zone, the cavitation zone, and the sub-boiling zone. Compared with argon plasma coagulation equipment, the argon-oxygen plasma jet device showed a smaller total area of liver thermal damage and smaller areas in the three zones, resulting in a lower degree of thermal damage.

[0116] Therefore, the argon-oxygen mixed plasma jet coagulation device provided in the embodiment of the present invention adopts a fixed-frequency modulated power supply to reduce power, and applies a self-calibration impedance matching system to adaptively adjust the output power as the coagulation wound changes, which can reduce heat loss to protect the normal tissue around the wound. At the same time, the biochemical effect and thermal effect generated by the low-temperature plasma jet are combined with coagulation, and oxygen is added to the argon gas. The argon-oxygen mixed gas can produce more active particles after plasma formation. The active particles activate platelets to accelerate coagulation, denature proteins, accelerate fibrinogen aggregation, etc., thereby promoting coagulation. The coagulation effect generated by the biochemical mechanism can reduce the heat required for partial coagulation. Experiments have shown that it can reduce the working temperature during coagulation, reduce the production of tissue carbonization eschar, and reduce the scope of thermal damage to surrounding normal tissues.

[0117] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. An argon-oxygen mixed plasma jet coagulation device, characterized in that: include: A jet reactor comprises a discharge electrode, a dielectric tube, and an insulating shell. The discharge electrode and the dielectric tube are disposed inside the insulating shell. Two ends of the discharge electrode form a connection end and a jet end, respectively. The jet end is disposed through the insulating shell and is suitable for forming a plasma jet beam. An airflow channel is formed inside at least one of the discharge electrode and the dielectric tube. a power module connected to the connection end; The gas supply component is connected to the gas flow channel and is used to supply a preset ratio of argon and oxygen mixed gas to the gas flow channel.

2. The argon-oxygen mixed plasma jet coagulation device according to claim 1, characterized in that: The ratio of argon to oxygen is between 9999:1 and 99:

1.

3. The argon-oxygen mixed plasma jet coagulation device according to claim 1, characterized in that: The dielectric tube is sleeved on the outer side of the discharge electrode, and the air flow channel is formed between the dielectric tube and the discharge electrode; The side wall of the insulating shell is provided with an air inlet channel, and the side wall of the medium tube is provided with a branch channel, the branch channel is connected to the air flow channel, the branch channel extends to the position of the air inlet channel and is connected to the air inlet channel; the air inlet channel is connected to the air supply assembly.

4. The argon-oxygen mixed plasma jet coagulation device according to claim 3, characterized in that: A hollow tube of a preset length is formed between the connecting end and the jet end of the discharge electrode. A side wall of the hollow tube is provided with an opening, and the air flow channel is communicated with the opening.

5. The argon-oxygen mixed plasma jet coagulation device according to claim 1, characterized in that: The dielectric tube and the discharge electrode are arranged in parallel inside the insulating shell, the dielectric tube forms a first airflow channel inside, and the discharge electrode forms a second airflow channel inside. The air supply assembly includes a first air pipe, a second air pipe, and air supply sources connected to the first air pipe and the second air pipe. The first air pipe is connected to the first air flow channel, and the second air pipe is connected to the second air flow channel.

6. The argon-oxygen mixed plasma jet coagulation device according to claim 5, characterized in that: Also included are adjustment components; The side wall of the insulating shell is provided with an adjustment groove, the adjustment component is provided in the adjustment groove and is connected to the discharge electrode, and the adjustment component is suitable for adjusting the position of the discharge electrode to be close to or away from the target tissue.

7. The argon-oxygen mixed plasma jet coagulation device according to any one of claims 1 to 6, characterized in that: The insulating housing has a first end and a second end that are oppositely disposed; The first end is provided with a lead channel, the second end is provided with a positioning hole, the connection end of the discharge electrode is passed through the lead channel and connected to the power module; the jet end of the discharge electrode is passed through the positioning hole.

8. The argon-oxygen mixed plasma jet coagulation device according to claim 7, characterized in that: It also includes a jet nozzle assembly, which is arranged at the second end of the insulating shell, and the air flow channel is connected to the jet nozzle assembly.

9. The argon-oxygen mixed plasma jet coagulation device according to claim 8, characterized in that: The jet nozzle assembly comprises: a nozzle component connected to the second end of the insulating housing; The drainage cylinder is rotatably arranged inside the nozzle component, and a through hole is provided inside the drainage cylinder, and the jet end of the discharge electrode is passed through the through hole; the outer circumferential surface of the drainage cylinder is provided with a drainage groove, and the drainage groove is spirally arranged along the axial direction of the drainage cylinder, and the drainage groove is connected to the airflow channel.

10. The argon-oxygen mixed plasma jet coagulation device according to any one of claims 1 to 6, characterized in that: The power supply module includes a power supply body and a self-calibration impedance matching system. The self-calibration impedance matching system is electrically connected to the power supply body and is used to adjust the power of the power supply body according to the impedance between the argon-oxygen mixed gas and the coagulation load.

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