Production process of gelatin hard hollow capsule

Abstract

The invention discloses a production process of gelatin hard hollow capsules, and relates to the technical field of pharmaceutic adjuvants, and the production process comprises the following steps: sol preparation, mold pretreatment, injection molding, preliminary drying, demolding, deep drying and the like, the main body structure of the dipping and drying integrated device is the glue dipping mold frame, T-shaped plates provided with a plurality of stainless steel rods are movably inserted into the upper surface and the lower surface of the glue dipping mold frame, the small stainless steel rods are arranged on the upper side and the lower side of the mold frame, and by means of the rotatable characteristic of the mold frame, the glue dipping and drying integrated device can be used for dipping the glue into the glue storage box. And when the lower stainless steel rod is subjected to glue dipping operation, the upper small stainless steel rod in a standby state can synchronously enter a cleaning station to be automatically cleaned, so that the overall production efficiency and the mold utilization rate are remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical excipients, in particular to a production process of hard hollow gelatin capsules. Background Art

[0002] Hard hollow capsules are pharmaceutical or health product packaging shells made primarily from animal collagen (gelatin). They are cylindrical, hollow structures consisting of a tightly fitting capsule body and cap. They are manufactured through processes such as sol preparation, injection molding, and staged drying. They exhibit high mechanical strength, controllable disintegration time, and excellent stability. They effectively protect the contents from environmental influences, mask the drug's odor, and facilitate swallowing. During production, capsule hardness is regulated by adjusting the glycerol ratio. The precision molds and degassing technology of the integrated capsule dipping and drying unit ensure uniform film quality, resulting in high biocompatibility and safety. However, after several cycles of use, gelatin particles, film edges, or aged gelatin will inevitably remain on the surface of the capsule molding mold. If these residues are not promptly cleaned, they can directly affect the quality of the next round of molding, leading to problems such as uneven film thickness, bubbles, and poor adhesion. Therefore, the mold requires regular cleaning.

[0003] Traditionally, this cleaning process is typically completed in a separate workstation or clean area. After a number of uses, the mold rods are removed from the main production line and sent to a dedicated cleaning unit, either manually or by automated equipment, for rinsing, scraping off dried glue, soaking in hot water, and even disinfection. They are then returned to the main line for continued use. However, this approach presents several significant issues. First, there is the long idling waiting time: cleaning and drying the molds takes time, and the molds cannot participate in production while in the cleaning area, resulting in reduced mold utilization. Production rhythm is interrupted: the main production line needs to wait for the molds to return, potentially leading to a "mold shortage" or "idle waiting" situation, impacting overall production capacity. Furthermore, there is a lack of synchronization with the main line: the cleaning process is out of sync with the main line's operating rhythm, making it difficult to achieve full process automation. Summary of the Invention

[0004] The purpose of the present invention is to solve the problem in the prior art that after several cycles of use of the capsule dipping and drying integrated device, the cleaning process of the capsule forming mold is usually completed in an independent workstation or clean area. After several uses, the mold rod needs to be removed from the main production line and sent to a dedicated cleaning unit by manual or automated equipment for operations such as rinsing with clean water, scraping off dried glue, soaking in hot water, and even disinfection. Before returning to the main line for continued use, however, this method has several obvious problems. The first is the long idling waiting time: the cleaning and drying of the mold takes time, and the mold cannot participate in production during the cleaning area, resulting in a decrease in mold utilization. A production process for hard hollow gelatin capsules is proposed.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions: A production process for hard hollow gelatin capsules comprises the following steps: sol preparation, mold pretreatment, injection molding, preliminary drying, demoulding, deep drying, cutting and fitting, and post-processing.

[0006] Optionally, the mass percentages of the components in the sol preparation are: gelatin 40-50%, glycerol 15-25%, and purified water 30-40%, and the capsule hardness is controlled by adjusting the glycerol ratio.

[0007] Optionally, the sol preparation includes the following process parameters: heating temperature is 60-70°C, stirring until completely dissolved, time is 30-60 minutes, vacuum degassing after sol, vacuum degree is -0.08~-1MPa, until the glue solution is clear.

[0008] Optionally, the mold pretreatment includes: using a 316L stainless steel mold, electroplating or polishing the surface to a mirror finish, and preheating the mold to 40-50°C.

[0009] Optionally, the injection molding comprises: feeding the prepared glue into an integrated glue dipping and drying device, wherein a transfer cylinder in the integrated glue dipping and drying device drives the mold to immerse into a glue storage box, the mold is immersed in the glue to a depth of 1 / 2 of the capsule length, stays for 2-3 seconds, and then is pulled up at a constant speed, and the thickness of the glue film is controlled to be 15-25 mm by the dipping speed and the viscosity of the glue; The integrated glue dipping and drying device includes a glue storage box, a T-shaped plate, a glue dipping mold frame, a horizontal rod, and a U-shaped frame. The horizontal surface of the T-shaped plate is equidistantly provided with multiple stainless steel rods. The bottom of the glue storage box is fixedly provided on the top of the workbench. A controller is provided on the side of the glue storage box. A dirt guide hopper is fixedly provided on one side of the glue storage box on the top of the workbench. A back plate is fixedly provided on the edge of the top of the workbench. A first drying oven and a second drying oven are fixedly provided on the side of the dirt guide hopper on the back plate in sequence. A horizontal groove is provided on the side of the back plate. A horizontal rod is movably inserted into the horizontal groove in the horizontal direction. A lifting cylinder is fixedly provided on the top of the horizontal rod. The output end of the lifting cylinder is fixedly provided with a U-shaped frame, the bottom of the U-shaped frame is fixedly provided with an edge block, the side of the edge block is rotatably connected to a step column, the other end of the step column is fixedly provided with a dipping mold frame, the upper and lower sides of the dipping mold frame are movably inserted with T-shaped plates, the front and rear sides of the dipping mold frame are provided with fast-fixing components for quickly disassembling and assembling the T-shaped plates, the end of the step column is fixedly provided with a self-limiting component for maintaining the dipping mold frame in a vertical state, the T-shaped plates are movably inserted with scraping plates on the outer walls of multiple stainless steel bars, and the side of the U-shaped frame is opened There is a vertical slot, a transfer cylinder is fixedly provided on one side of the top of the U-shaped frame, a driving block is fixedly provided on the output end of the transfer cylinder, a cleaning box is fixedly provided on the other end of the driving block, a lifting electromagnet is fixedly provided on the top of the cleaning box, and a negative pressure cleaning component is provided on the top of the cleaning box. When the lifting electromagnet drives the scraper plate to move to a certain position, the negative pressure cleaning component automatically sucks out the residual glue particles for cleaning. A safety driving component is provided on the side of the cleaning box to prevent the cleaning box from accidentally moving downward when the dipping mold frame rotates; transfer screws are threaded into both ends of the horizontal rod, and both ends of the transfer screw are rotatably connected to the two ends of the horizontal slot, one end of the transfer screw is fixedly connected to the output end of the transfer motor, and the transfer motor housing is fixedly provided on the side of the back plate; The quick-fix assembly includes a threaded column, an edge stopper and an intermediate rod, both ends of the intermediate rod are fixedly provided with edge stops, the side of the edge stopper is provided with a transverse groove, the side edge of the dipping mold frame is fixedly provided with a threaded column, the threaded column passes through the transverse groove, and the end of the threaded column is screwed into a locking handle; the self-limiting assembly includes a protective folding cover, a locking worm, and a locking turbine, the protective folding cover is fixedly provided on the side of one of the edge blocks, the end of the stepped column is fixedly provided with a locking turbine, the top of the locking turbine is stably engaged with a locking worm, and both ends of the locking worm are rotatably connected to the side of the protective folding cover; The in-place negative pressure cleaning assembly includes an AC pipe, a top wide cylinder, a bottom narrow cylinder and a one-way valve, the bottom narrow cylinder is fixedly connected to the top of the cleaning box, a one-way valve is fixedly provided on the side of the cleaning box, the top of the bottom narrow cylinder is fixedly connected to the top wide cylinder, the bottom narrow cylinder is movably inserted with an AC pipe in the vertical direction, an AC hole is provided on the side of the AC pipe, the AC pipe is fixedly connected to one end of a vertical spring, the other end of the vertical spring is fixedly connected to the top of the top wide cylinder, and the side of the top wide cylinder is fixedly connected to a suction pipe; mounting grooves are provided at the upper and lower ends of the side surface of the T-shaped plate, the T-shaped plate is provided with an avoidance hole at the top of the mounting groove, the bottom of the mounting groove is fixedly connected to one end of a reset spring, and the top of the reset spring passes through the avoidance hole and is fixedly connected to the bottom of the scraper plate; The safety drive assembly includes a vertical plate, a drive motor, an extension plate, and a drive gear. The side of the extension plate is fixedly connected to the side of the cleaning box, the other end of the extension plate is fixedly provided with a vertical plate, the side of the vertical plate is fixedly provided with a drive motor, the output end of the drive motor is fixedly provided with a drive gear, one end of the locking worm is fixedly provided with an auxiliary crank, the other end of the locking worm is fixedly provided with a driven gear, the driven gear is stably engaged with the drive gear, a mounting plate is fixedly provided on the top of the vertical plate, a photoelectric sensor is fixedly provided on the bottom of the mounting plate, a light shielding plate is fixedly provided on the outer wall of the output end of the drive motor, a limiting column is fixedly provided on the bottom of the extension plate, a safety hole is opened at the top of the stepped column, and the limiting column has the same diameter as the safety hole.

[0010] Optionally, the deep drying is a two-stage drying: the integrated glue-dipping and drying device drives the formed capsule preform to move to the second oven position for the first stage drying, and the temperature of the hot air introduced into the second oven is 30°C and the humidity is 30%. The capsule preform is dried here for 2-4 hours, and the moisture content of the capsule preform is reduced to 15-18%; the integrated glue-dipping and drying device drives the formed capsule preform to move to the first oven position, and the temperature of the hot air introduced into the first oven is 25°C and the humidity is 20%. The capsule preform is dried here for 1-2 hours, and the moisture content of the capsule preform is finally 12-14%.

[0011] Optionally, the cutting and fitting include: laser or blade cutting, with the capsule body / cap length error being ≤5 mm; mechanical fitting pressure being 5-10 N, and polishing with food-grade lubricant after fitting.

[0012] Compared with the prior art, the present invention has the following advantages: 1. The main structure of the integrated dipping and drying device of the present invention is a dipping mold frame. T-shaped plates with multiple stainless steel rods installed are movably inserted on the upper and lower sides of the dipping mold frame. Small stainless steel rods are set on the upper and lower sides of the mold frame. The rotatable characteristics of the mold frame are used so that when the lower stainless steel rod is dipping, the upper small stainless steel rod in a standby state can be synchronously entered into the cleaning station for automatic cleaning. This design can significantly improve the overall production efficiency and mold utilization rate. On the one hand, it avoids the time wasted in the traditional mode of alternating dipping and cleaning, which causes the mold to idle and wait; on the other hand, with the help of the rotary switching mechanism of the mold frame, the dipping and cleaning processes are run in parallel, so that while the mold completes the dipping and molding work on one side, the mold on the other side is automatically cleaned and prepared for the next use, thereby forming a cyclic and efficient operation process. It not only improves the continuous working capacity of the equipment, but also greatly reduces manual intervention and cleaning waiting time, which helps to improve the beat and yield of capsule production.

[0013] 2. The present invention provides scraping plates on both T-shaped plates, and a cleaning box is provided above one of the T-shaped plates. A lifting electromagnet and an in-place negative pressure cleaning component are sequentially provided on the top of the cleaning box. By utilizing the rotatable characteristic of the mold frame, when the stainless steel rod group below is performing the glue dipping operation, the cleaning box can wrap the small stainless steel rod group above that is in a standby state. The lifting electromagnet provided on the top of the cleaning box is used to attract the scraping plate to move up to a certain position. The scraping plate and the interior of the cleaning box form a small cavity, which will trigger the in-place negative pressure cleaning component. The dust suction structure outside the in-place negative pressure cleaning component is used to suck away the residual glue particles to avoid contamination of other components during the cleaning process. This design not only realizes automatic judgment of whether the scraping plate is in place, ensures that the cleaning process is only carried out in a confined space, prevents glue particles from splashing and polluting the environment, but also improves cleaning efficiency and the reusability of glue sticks, greatly reduces manual wiping and cleaning time, thereby reducing production costs, improving the level of equipment automation and operating rhythm, and ensuring the consistency and stability of capsule quality.

[0014] 3. The present invention is provided with a safety drive assembly on the side of the dipping mold frame's rotating shaft. The safety drive assembly is specifically provided on the side of the cleaning box. When the cleaning box moves down to the spare small stainless steel rod group on the top of the dipping mold frame, the safety drive assembly cannot drive the dipping mold frame to rotate. The safety drive assembly will lose the ability to drive the mold frame to rotate, thereby effectively preventing structural damage such as collisions and scratches caused by the mold frame's misrotation during the cleaning process. A "position interlocking" mechanism is implemented, that is, the mold frame is only able to rotate when the cleaning box is in a non-interference position, thereby enhancing the coordination and safety of the system operation. This not only avoids the risk of device interference caused by misoperation or abnormal system instructions, but also improves the equipment's fault tolerance and operational stability. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the overall structure of the integrated device for dipping and drying of the present invention.

[0016] Figure 2 for Figure 1 Another perspective structural diagram.

[0017] Figure 3 It is a structural diagram of the U-shaped frame and its connecting parts.

[0018] Figure 4 for Figure 3 Schematic diagram of the structure with the U-shaped frame removed.

[0019] Figure 5 for Figure 3 Another perspective structural diagram.

[0020] Figure 6 This is a schematic diagram of the structure of the safety drive component.

[0021] Figure 7 It is a structural diagram of the negative pressure cleaning component in place.

[0022] Figure 8 It is a structural diagram of the AC tube and its connecting parts.

[0023] Figure 9 It is a structural diagram of the dipped mold frame and its connecting parts.

[0024] Figure 10 for Figure 9 Another perspective structural diagram.

[0025] Figure 11 Schematic diagram of the structure of the fast-setting component.

[0026] Figure: 1, glue storage box; 2, injection pipe; 3, controller; 4, back plate; 41, horizontal slot; 5, workbench; 51, dirt guide hopper; 6, first oven; 7, second oven; 8, transfer motor; 81, transfer screw; 9, lifting cylinder; 10, horizontal rod; 11, U-shaped frame; 110, vertical slot; 112, edge block; 12, driven gear; 13, locking worm; 131, auxiliary crank; 14, cleaning box; 15, non-return valve; 16, lifting electromagnet; 17, bottom narrow cylinder; 18, drive block; 19, transfer cylinder; 20, protective folding cover; 21, vertical plate; 2 2. Mounting plate; 221. Photoelectric sensor; 23. Sunshade; 24. Drive motor; 241. Drive gear; 25. Extension plate; 251. Limit column; 26. Top width cylinder; 261. Intake pipe; 27. Vertical spring; 28. AC pipe; 29. AC hole; 30. Step column; 301. Locking turbine; 31. Safety hole; 32. Scraper plate; 321. Return spring; 33. Glue-dipping mold frame; 331. Threaded column; 34. T-plate; 35. Mounting slot; 36. Avoidance hole; 37. Intermediate rod; 38. Edge stopper; 381. Transverse slot; 39. Locking handle. DETAILED DESCRIPTION

[0027] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0028] In the description of the present invention, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating directions or positional relationships, are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore should not be understood as limiting the present invention.

[0029] Reference Figure 1-11A production process for hard hollow gelatin capsules includes the following steps: sol preparation, mold pretreatment, injection molding, preliminary drying, demoulding, deep drying, cutting and fitting, and post-processing. The mass percentage of each component in the sol preparation is: gelatin 40-50%, glycerin 15-25%, and purified water 30-40%, and the capsule hardness is controlled by adjusting the glycerin ratio. The sol preparation includes the following process parameters: heating temperature of 60-70℃, stirring until completely dissolved, time 30-60 minutes, vacuum degassing after sol, vacuum degree of -0.08~-0.1MPa, until the glue liquid is clear; mold pretreatment includes: using 316L stainless steel mold, the surface is electroplated or polished to a mirror surface, and the mold is preheated to 40-50℃. Injection molding includes: sending the prepared glue liquid into the inside of the glue dipping and drying integrated device, the transfer cylinder 19 in the glue dipping and drying integrated device drives the mold to immerse into the glue storage box 1, the mold is immersed in the glue liquid to a depth of 1 / 2 of the capsule length, stays for 2-3 seconds and then pulled up at a uniform speed, and the thickness of the glue film is controlled to 0.15-0.25 mm by the dipping speed and the viscosity of the glue liquid.

[0030] The glue dipping and drying integrated device includes a glue storage box 1, a T-shaped plate 34, a glue dipping mold frame 33, a horizontal rod 10, and a U-shaped frame 11. A plurality of stainless steel rods are equidistantly arranged on the horizontal surface of the T-shaped plate 34. An injection pipe 2 is arranged on the top of the side of the glue storage box 1. The bottom of the glue storage box 1 is fixedly arranged on the top of the workbench 5. A controller 3 is arranged on the side of the glue storage box 1. The controller 3 selects a PLC controller commonly used in the prior art. A dirt guide hopper 51 is fixedly arranged on the top of the workbench 5 on one side of the glue storage box 1. The dirt guide hopper 51 is used to collect the dirt dripping from the bottom of the glue dipping and drying integrated device when it is transferred to different workstations. The glue falls, a backboard 4 is fixedly provided at the top edge of the workbench 5, and the first oven 6 and the second oven 7 are fixedly provided on the side of the dirt guide hopper 51 of the backboard 4 in sequence. A horizontal groove 41 is opened on the side of the backboard 4, and a horizontal rod 10 is inserted into the horizontal groove 41 movably in the horizontal direction. A lifting cylinder 9 is fixed on the top of the horizontal rod 10, and transfer screws 81 are threaded into both ends of the horizontal rod 10. Both ends of the transfer screw 81 are rotatably connected to the two ends of the horizontal groove 41, and one end of the transfer screw 81 is fixedly connected to the output end of the transfer motor 8. The shell of the transfer motor 8 is fixedly provided on the side of the backboard 4.

[0031] The output end of the lifting cylinder 9 is fixedly provided with a U-shaped frame 11, and an edge block 112 is fixedly provided at the bottom of the U-shaped frame 11. The side of the edge block 112 is rotatably connected to the step column 30. The other end of the step column 30 is fixedly provided with a dipping mold frame 33. The upper and lower surfaces of the dipping mold frame 33 are movably inserted with T-shaped plates 34. The front and rear surfaces of the dipping mold frame 33 are provided with fast-fixing components for quickly disassembling and assembling the T-shaped plates 34. The fast-fixing components include a threaded column 331, an edge block 38 and an intermediate rod 37. , edge blocks 38 are fixedly provided at both ends of the middle rod 37, and a transverse groove 381 is opened on the side of the edge block 38. A threaded column 331 is fixedly provided at the edge position of the side of the glue dipping mold frame 33. The threaded column 331 passes through the transverse groove 381, and a locking handle 39 is screwed into the end of the threaded column 331. When the T-shaped plate 34 is inserted into the glue dipping mold frame 33, the edge block 38 can be moved transversely to the front and back of the T-shaped plate 34 to quickly fix the two groups of glue dipping stainless steel rods.

[0032] A self-limiting component is fixedly provided at the end of the stepped column 30 for maintaining the dipping mold frame 33 in a vertical state. A scraper plate 32 is movably inserted into the outer wall of a plurality of stainless steel rods on the T-shaped plate 34. A vertical groove 110 is provided on the side of the U-shaped frame 11. A transfer cylinder 19 is fixedly provided on one side of the top of the U-shaped frame 11. A driving block 18 is fixedly provided on the output end of the transfer cylinder 19. A cleaning box 14 is fixedly provided on the other end of the driving block 18. A lifting electromagnet 16 is fixedly provided on the top of the cleaning box 14. An in-place negative pressure cleaning component is provided on the top of the cleaning box 14. When the lifting electromagnet 16 drives the scraper plate 32 to move up to a certain position, the in-place negative pressure cleaning component automatically performs negative pressure suction and cleaning on the residual glue particles. A safety driving component is provided on the side of the cleaning box 14 to prevent the cleaning box 14 from accidentally moving downward when the dipping mold frame 33 rotates.

[0033] The self-limiting assembly includes a protective folding cover 20, a locking worm 13, and a locking turbine 301. The protective folding cover 20 is fixedly arranged on the side of one of the edge blocks 112. The locking turbine 301 is fixedly arranged at the end of the stepped column 30. The top of the locking turbine 301 is stably engaged with the locking worm 13. Both ends of the locking worm 13 are rotatably connected to the side of the protective folding cover 20. The in-place negative pressure cleaning component includes an AC pipe 28, a top wide cylinder 26, a bottom narrow cylinder 17 and a one-way valve 15. The bottom narrow cylinder 17 is fixedly connected to the top of the cleaning box 14, and a one-way valve 15 is fixedly provided on the side of the cleaning box 14. The top of the bottom narrow cylinder 17 is fixedly connected to the top wide cylinder 26. The AC pipe 28 is movably inserted into the bottom narrow cylinder 17 in the vertical direction. An AC hole 29 is provided on the side of the AC pipe 28. The AC pipe 28 is fixedly connected to one end of the vertical spring 27, and the other end of the vertical spring 27 is fixedly connected to the top of the top wide cylinder 26. The side of the top wide cylinder 26 is fixedly connected to the suction pipe 261, and the suction pipe 261 is externally connected to the dust extraction system.

[0034] Mounting grooves 35 are provided at the upper and lower ends of the side surface of the T-shaped plate 34. An avoidance hole 36 is provided at the top of the mounting groove 35 of the T-shaped plate 34. The bottom of the mounting groove 35 is fixedly connected to one end of the return spring 321. The top of the return spring 321 passes through the avoidance hole 36 and is fixedly connected to the bottom of the scraping plate 32. The scraping plate 32 is made of iron. When the return spring 321 is at its original length, the scraping plate 32 fits onto the surface of the T-shaped plate 34.

[0035] The safety drive assembly includes a vertical plate 21, a drive motor 24, an extension plate 25, and a drive gear 241. The side of the extension plate 25 is fixedly connected to the side of the cleaning box 14, and the other end of the extension plate 25 is fixedly provided with a vertical plate 21. The side of the vertical plate 21 is fixedly provided with a drive motor 24. The output end of the drive motor 24 is fixedly provided with a drive gear 241. One end of the locking worm 13 is fixedly provided with an auxiliary crank 131. The setting of the auxiliary crank 131 makes it convenient for the user to rotate the locking worm 13 to drive the entire structure to reset. The other end of the locking worm 13 is fixedly provided with a driven gear 12. The driven gear 12 is stably engaged with the drive gear 241. The drive gear 241 is below the driven gear 12. When one end of the locking worm 13 is not subjected to external force, the locking worm 13 cooperates with the locking turbine 301 to maintain the entire dipping mold frame 33 at the desired angle.

[0036] A mounting plate 22 is fixedly provided on the top of the vertical plate 21, a photoelectric sensor 221 is fixedly provided on the bottom of the mounting plate 22, a light shielding plate 23 is fixedly provided on the outer wall of the output end of the driving motor 24, and the light shielding plate 23 can enter the gap of the photoelectric sensor 221. The setting of the light shielding plate 23 and the photoelectric sensor 221 is used to reset the output end of the driving motor 24, a limiting column 251 is fixedly provided on the bottom of the extension plate 25, and a safety hole 31 is opened on the top of the stepped column 30, and the limiting column 251 has the same diameter as the safety hole 31.

[0037] Deep drying is a two-stage drying process: Air outlet holes are evenly spaced on the sides of the first oven 6 and the second oven 7. The first oven 6 and the second oven 7 are connected to different drying equipment respectively. The drying temperature and humidity of the gas generated by the two drying equipment are different. The integrated glue dipping and drying device drives the formed capsule preforms to move to the second oven 7 for the first stage of drying. The hot air introduced into the second oven 7 has a temperature of 30°C and a humidity of 30%. The capsule preforms are dried here for 2-4 hours, and the moisture content of the capsule preforms is reduced to 15-18%. The integrated dipping and drying device drives the formed capsule preform to move to the first oven 6. The hot air introduced into the first oven 6 has a temperature of 25°C and a humidity of 20%. The capsule preform is dried here for 1-2 hours, and the moisture content of the capsule preform is finally 12-14%.

[0038] Cutting and fitting include: laser or blade cutting, the capsule body / cap length error is ≤0.5 mm; the mechanical fitting pressure is 5-10 N, and after fitting, it is polished with food-grade lubricant.

[0039] The specific implementation steps and principles of the capsule dipping and drying integrated device of the present invention are as follows: When the stainless steel rod group under the dipping mold frame 33 is working normally, the scraper plate 32 is in a state of being in contact with the surface of the dipping mold frame 33. At this time, the AC hole 29 is retracted into the bottom narrow cylinder 17, and the dust collection system externally connected to the suction pipe 261 is not connected to the AC pipe 28. When the stainless steel rod group on the top of the dipping mold frame 33 needs to be cleaned, the transfer cylinder 19 and the lifting electromagnet 16 are both started, extending to drive the cleaning box 14 to move down and wrap the stainless steel rod group on the top of the dipping mold frame 33. The lifting electromagnet 16 will generate a magnetic The scraper plate 32 is driven upward by the force of the force, and when the scraper plate 32 moves to a certain position, it pushes the AC tube 28 to move upward and be compressed, and the AC hole 29 enters the top wide cylinder 26. At this time, the external dust collection system is connected with the cleaning box 14. At the same time, the driving gear 241 at the output end of the driving motor 24 moves downward and separates from the driven gear 12. At this time, due to the presence of the locking worm 13 and the locking turbine 301, the entire dipping mold frame 33 remains stable and motionless, and the limiting column 251 is inserted into the limiting hole 301.

[0040] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A production process for hard empty gelatin capsules, characterized in that: The following steps are involved: Sol preparation, mold pretreatment, injection molding, preliminary drying, demoulding, deep drying, cutting and fitting, and post-processing.

2. The production process of a gelatin hard hollow capsule according to claim 1, characterized in that: The mass percentages of the components in the sol preparation are: gelatin 40-50%, glycerin 15-25%, and purified water 30-40%, and the capsule hardness is controlled by adjusting the glycerin ratio.

3. The production process of a gelatin hard hollow capsule according to claim 1, characterized in that: The sol preparation includes the following process parameters: The heating temperature is 60-70℃, stirring until completely dissolved, the time is 30-60 minutes, and vacuum degassing after the sol, the vacuum degree is -0.08~-0.1MPa, until the glue solution is clear.

4. The production process of a hard empty gelatin capsule according to claim 1, characterized in that: The mold pretreatment includes: Use 316L stainless steel mold, the surface is electroplated or polished to a mirror finish, and the mold is preheated to 40-50°C.

5. The production process of a hard empty gelatin capsule according to claim 1, characterized in that: The injection molding comprises: The prepared glue liquid is sent into the integrated glue dipping and drying device. The transfer cylinder in the integrated glue dipping and drying device drives the mold to immerse into the glue storage box. The mold is immersed in the glue liquid to a depth of 1 / 2 of the capsule length. After staying for 2-3 seconds, it is pulled up at a constant speed. The thickness of the glue film is controlled by the dipping speed and the viscosity of the glue liquid to 0.15-0.25 mm; The integrated glue dipping and drying device includes a glue storage box, a T-shaped plate, a glue dipping mold frame, a horizontal rod, and a U-shaped frame. The horizontal surface of the T-shaped plate is equidistantly provided with multiple stainless steel rods. The bottom of the glue storage box is fixedly provided on the top of the workbench. A controller is provided on the side of the glue storage box. A dirt guide hopper is fixedly provided on one side of the glue storage box on the top of the workbench. A back plate is fixedly provided on the edge of the top of the workbench. A first drying oven and a second drying oven are fixedly provided on the side of the dirt guide hopper on the back plate in sequence. A horizontal groove is provided on the side of the back plate. A horizontal rod is movably inserted into the horizontal groove in the horizontal direction. A lifting cylinder is fixedly provided on the top of the horizontal rod. The output end of the lifting cylinder is fixedly provided with a U-shaped frame, the bottom of the U-shaped frame is fixedly provided with an edge block, the side of the edge block is rotatably connected to a step column, the other end of the step column is fixedly provided with a dipping mold frame, the upper and lower sides of the dipping mold frame are movably inserted with T-shaped plates, the front and rear sides of the dipping mold frame are provided with fast-fixing components for quickly disassembling and assembling the T-shaped plates, the end of the step column is fixedly provided with a self-limiting component for maintaining the dipping mold frame in a vertical state, the T-shaped plates are movably inserted with scraping plates on the outer walls of multiple stainless steel bars, and the side of the U-shaped frame is opened There is a vertical groove, a transfer cylinder is fixedly provided on one side of the top of the U-shaped frame, a driving block is fixedly provided on the output end of the transfer cylinder, a cleaning box is fixedly provided on the other end of the driving block, a lifting electromagnet is fixedly provided on the top of the cleaning box, and an in-place negative pressure cleaning component is provided on the top of the cleaning box. When the lifting electromagnet drives the scraper plate to move to a certain position, the in-place negative pressure cleaning component automatically sucks and cleans the residual glue particles with negative pressure. A safety driving component is provided on the side of the cleaning box to prevent the cleaning box from accidentally moving downward when the dipping mold frame rotates; Transfer screws are threaded into both ends of the horizontal rod, and both ends of the transfer screws are rotatably connected to the two ends of the horizontal slot. One end of the transfer screw is fixedly connected to the output end of the transfer motor, and the transfer motor housing is fixedly arranged on the side of the back plate; The quick-setting assembly includes a threaded column, an edge block, and an intermediate rod. The intermediate rod is fixed with an edge block at both ends. The side of the edge block is provided with a transverse groove. The edge of the side of the dipping mold frame is fixed with a threaded column. The threaded column passes through the transverse groove. The end of the threaded column is screwed into a locking handle. The self-limiting assembly includes a protective folding cover, a locking worm, and a locking turbine. The protective folding cover is fixedly arranged on the side of one of the edge blocks. The end of the stepped column is fixedly provided with a locking turbine. The top of the locking turbine is stably engaged with a locking worm. Both ends of the locking worm are rotatably connected to the side of the protective folding cover. The in-place negative pressure cleaning assembly includes an AC pipe, a top wide cylinder, a bottom narrow cylinder and a one-way valve, the bottom narrow cylinder is fixedly connected to the top of the cleaning box, the side of the cleaning box is fixedly provided with a one-way valve, the top of the bottom narrow cylinder is fixedly connected to the top wide cylinder, the bottom narrow cylinder is movably inserted with an AC pipe in the vertical direction, an AC hole is opened on the side of the AC pipe, the AC pipe is fixedly connected to one end of a vertical spring, the other end of the vertical spring is fixedly connected to the top of the top wide cylinder, and the side of the top wide cylinder is fixedly connected to an air intake pipe; The T-shaped plate has mounting grooves at both ends, and a relief hole is formed at the top of the mounting groove. The bottom of the mounting groove is fixedly connected to one end of a return spring, and the top of the return spring passes through the relief hole and is fixedly connected to the bottom of the scraper plate. The safety drive assembly includes a vertical plate, a drive motor, an extension plate, and a drive gear. The side of the extension plate is fixedly connected to the side of the cleaning box, the other end of the extension plate is fixedly provided with a vertical plate, the side of the vertical plate is fixedly provided with a drive motor, the output end of the drive motor is fixedly provided with a drive gear, one end of the locking worm is fixedly provided with an auxiliary crank, the other end of the locking worm is fixedly provided with a driven gear, the driven gear is stably engaged with the drive gear, a mounting plate is fixedly provided on the top of the vertical plate, a photoelectric sensor is fixedly provided on the bottom of the mounting plate, a light shielding plate is fixedly provided on the outer wall of the output end of the drive motor, a limiting column is fixedly provided on the bottom of the extension plate, a safety hole is opened at the top of the stepped column, and the limiting column has the same diameter as the safety hole.

6. The production process of a hard empty gelatin capsule according to claim 1, characterized in that: The deep drying is a two-stage drying: The integrated dipping and drying device drives the formed capsule preforms to move to the second oven for the first stage of drying. The hot air introduced into the second oven has a temperature of 30°C and a humidity of 30%. The capsule preforms are dried here for 2-4 hours until the moisture content of the capsule preforms is reduced to 15-18%. The integrated dipping and drying device drives the formed capsule preforms to move to the first oven position. The hot air introduced into the first oven has a temperature of 25°C and a humidity of 20%. The capsule preforms are dried here for 1-2 hours, and the final moisture content of the capsule preforms is 12-14%.

7. The production process of a hard empty gelatin capsule according to claim 1, characterized in that: The cutting and fitting include: laser or blade cutting, with the capsule body / cap length error ≤0.5 mm; mechanical fitting pressure of 5-10 N, and polishing with food-grade lubricant after fitting.

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