Composition for relieving itching and diminishing swelling and ointment thereof

Abstract

The invention discloses a composition for relieving itching and diminishing swelling and an ointment thereof, the composition comprises 5-50 parts of mint, 5-50 parts of wormwood and others, the weight ratio of the mint to the wormwood is 1: 1, through reasonable raw material composition and dosage proportion, the composition can achieve the effects of quickly diminishing swelling and relieving itching on itching, red swelling and other symptoms caused by mosquito bites, and the ointment is free of toxic and side effects and free of side effects. Especially when the weight ratio of mint to wormwood is 1: 1, pruritus can be obviously relieved and the effect of fading red and swollen is obvious in most of six minutes.

Description

Technical Field

[0001] The present invention relates to the technical field of medicine, in particular to a composition for relieving itching and swelling and an ointment thereof. Background Art

[0002] When mosquitoes bite, they inject saliva containing anticoagulants into the skin. The human immune system releases substances such as histamine to combat foreign substances, causing local vasodilation and tissue fluid leakage, resulting in redness, swelling, itching, and lumps. The itching and redness caused by mosquito bites can be painful, and scratching can aggravate the inflammatory response, leading to skin damage and bacterial infection, especially in children with poor self-control. The redness, swelling, or lumps after a mosquito bite typically subside within 3-7 days, prolonging the pain. Although there are currently commercially available products to relieve itching and swelling for mosquito bites, they are slow to work and do not quickly relieve the pain. Summary of the Invention

[0003] Therefore, based on the above background, the present invention provides a composition for relieving itching and swelling and an ointment thereof, which has a quick effect, can quickly relieve itching and swelling, and is safe and non-irritating.

[0004] The technical solution provided by the present invention is:

[0005] A composition for relieving itching and reducing swelling comprises 5-50 parts of mint and 5-50 parts of wormwood by weight.

[0006] Furthermore, it also includes at least two of the following raw materials by weight:

[0007] 5-50 parts of Artemisia annua, 5-50 parts of honeysuckle, 5-20 parts of rosemary, 2-10 parts of angelica dahurica, 5-20 parts of perilla, 5-20 parts of jasmine, 5-30 parts of gynostemma pentaphyllum, and 5-20 parts of citronella.

[0008] Furthermore, it is composed of the following raw materials in parts by weight:

[0009] 5-50 parts of Artemisia argyi, 5-50 parts of honeysuckle, 5-20 parts of rosemary, 5-20 parts of honeysuckle, 2-10 parts of Angelica dahurica, 5-20 parts of Perilla frutescens, 5-20 parts of jasmine, 5-30 parts of Gynostemma pentaphyllum, 5-20 parts of citronella, 5-50 parts of mint, and 5-50 parts of wormwood.

[0010] Furthermore, it is composed of the following raw materials in parts by weight:

[0011] 5-50 parts of honeysuckle, 5-20 parts of rosemary, 5-20 parts of perilla, 2-10 parts of angelica dahurica, 5-20 parts of jasmine, 5-50 parts of mint, and 5-50 parts of wormwood.

[0012] Furthermore, the weight ratio of mint to mugwort is 1:1.

[0013] Based on the same inventive concept, the present invention also provides the use of the above-mentioned antipruritic and anti-swelling composition in the preparation of a preparation for relieving redness, swelling and itching caused by mosquito bites.

[0014] Based on the same inventive concept, the present invention also provides an antipruritic and anti-swelling ointment, which is prepared from the above-mentioned antipruritic and anti-swelling composition and a medically accepted adjuvant.

[0015] Furthermore, the preparation of the antipruritic and anti-swelling ointment of the present invention comprises the following steps:

[0016] 1) taking the raw material components of the composition in proportion, drying them, and then crushing them;

[0017] 2) adding the crushed material into base oil, the base oil at least immersing the material, and then soaking for 1-24 hours;

[0018] 3) Wrap the impregnated material with plastic wrap, steam it for 1.5-3 hours, cool it, squeeze the material, squeeze out the liquid, let it stand for 1-24 hours, and then take the upper liquid;

[0019] 4) Add beeswax and wormwood ash to the above liquid, heat the beeswax until it is completely melted, stir, and wait for it to cool and solidify into a paste.

[0020] Furthermore, in step 4), after the beeswax is completely melted, vitamin E is added under stirring, and the paste is cooled and solidified.

[0021] Furthermore, the base oil in step 3) is selected from olive oil or camellia oil.

[0022] The beneficial effects achieved by the present invention are:

[0023] The present invention can quickly relieve swelling and itching caused by itching, redness and swelling caused by mosquito bites through a reasonable raw material composition and usage ratio. Especially when the weight ratio of mint to wormwood is 1:1, most of the time, the itching can be significantly relieved and the redness and swelling can be significantly reduced within 6 minutes.

[0024] The present invention can also be used to relieve muscle soreness and refresh the mind. DETAILED DESCRIPTION

[0025] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0026] Example 1: An antipruritic and anti-swelling ointment, which is prepared from an antipruritic and anti-swelling composition and a medically accepted adjuvant;

[0027] The antipruritic and anti-swelling composition is composed of the following raw materials in parts by weight:

[0028] 5-50 parts of Artemisia argyi, 5-50 parts of mint, 5-50 parts of honeysuckle, 5-20 parts of rosemary, 5-20 parts of honeysuckle, 2-10 parts of Angelica dahurica, 5-20 parts of Perilla frutescens, 5-20 parts of jasmine, 5-30 parts of Gynostemma pentaphyllum, 5-20 parts of citronella, 5-50 parts of mint, and 5-50 parts of wormwood.

[0029] The specific composition and dosage of the antipruritic and anti-swelling composition of this embodiment are as follows:

[0030] 20 parts of Artemisia argyi, 20 parts of honeysuckle, 15 parts of rosemary, 10 parts of honeysuckle, 8 parts of the Radix Angelicae Dahuricae, 15 parts of Perilla frutescens, 15 parts of Flos Jasminum, 15 parts of Gynostemma pentaphyllum, 10 parts of citronella, 30 parts of peppermints, 30 parts of wormwood.

[0031] Example 2: An antipruritic and anti-swelling ointment, which is prepared from an antipruritic and anti-swelling composition and a medically accepted adjuvant;

[0032] The antipruritic and anti-swelling composition is composed of the following raw materials in parts by weight:

[0033] 5-50 parts of honeysuckle, 5-20 parts of rosemary, 5-20 parts of perilla, 2-10 parts of angelica dahurica, 5-20 parts of jasmine, 5-50 parts of mint, and 5-50 parts of wormwood.

[0034] The specific composition and dosage of the antipruritic and anti-swelling composition of this embodiment are as follows:

[0035] 15 parts of honeysuckle, 15 parts of rosemary, 10 parts of perilla, 10 parts of the root of angelica dahurica, 10 parts of jasmine flowers, 30 parts of peppermints, 30 parts of wormwood.

[0036] The preparation of the antipruritic and anti-swelling ointment of Example 1 and Example 2 comprises the following steps:

[0037] 1) taking the raw material components of the composition in proportion, drying them, and then crushing them;

[0038] 2) Add the crushed material to camellia oil, at least enough to submerge the material, and then soak for 24 hours;

[0039] 3) Wrap the impregnated material with plastic wrap, steam it for 3 hours, cool it, squeeze the material, squeeze out the liquid, let it stand for 20 hours, and then take the upper liquid;

[0040] 4) beeswax (the volume of beeswax added is 1 / 5-1 / 3 of the upper liquid, and in specific applications, the amount added is 1 / 3) and wormwood ash (5-30 parts, the amount of wormwood ash added in Example 1 and Example 2 is 8 parts) are added to the upper liquid, the beeswax is heated until completely melted, and after stirring, vitamin E (5-10 parts, the amount of vitamin E added in Example 1 and Example 2 is 5 parts) is added and the paste is cooled and solidified.

[0041] Comparative Example 1: An antipruritic and anti-swelling ointment, which is prepared from an antipruritic and anti-swelling composition and a medically accepted adjuvant;

[0042] The antipruritic and anti-swelling composition is composed of the following raw materials in parts by weight:

[0043] 15 parts of Flos Honeysuckle, 15 parts of Rosemary, 10 parts of Perilla, 10 parts of the Radix Angelicae Dahuricae, 10 parts of Flos Jasminum, 40 parts of Menthol, 20 parts of Artemisia selengensis.

[0044] Compared with Example 2, the total amount of mint and wormwood in this example remains unchanged, but the ratio of mint to wormwood is 2:1.

[0045] Comparative Example 2: An antipruritic and anti-swelling ointment, which is prepared from an antipruritic and anti-swelling composition and a medically accepted adjuvant;

[0046] The antipruritic and anti-swelling composition is composed of the following raw materials in parts by weight:

[0047] 15 parts of honeysuckle, 15 parts of rosemary, 10 parts of perilla, 10 parts of the root of angelica dahurica, 10 parts of jasmine flowers, 20 parts of peppermints, 40 parts of wormwood.

[0048] Compared with Example 2, the total amount of mint and wormwood in this example remains unchanged, but the ratio of mint to wormwood is 1:2.

[0049] Comparative Example 3: An antipruritic and anti-swelling ointment, which is prepared from an antipruritic and anti-swelling composition and a medically accepted adjuvant;

[0050] The antipruritic and anti-swelling composition is composed of the following raw materials in parts by weight:

[0051] 15 parts of Flos Honeysuckle, 15 parts of Rosemary, 10 parts of Perilla, 10 parts of the Radix Angelicae Dahuricae, 10 parts of Flos Jasmine, 15 parts of Peppermints, 45 parts of Artemisia selengensis.

[0052] Compared with Example 2, the total amount of mint and wormwood in this example remains unchanged, but the ratio of mint to wormwood is 1:3.

[0053] The preparation of the antipruritic and anti-swelling ointments of Comparative Examples 1 to 3 is the same as that of Examples 1 and 2.

[0054] The ointment of Example 2 was subjected to a patch test (referring to ISO 10993-10), and the result showed that the irritation was level 0, and it is suitable for infants over 6 months old and people with sensitive skin.

[0055] Animal experiments:

[0056] 60 adult Kunming mice were randomly divided into 4 groups, 15 mice in each group, namely experimental group, comparative example group 1, comparative example group 2, and comparative example group 3. The fur of each mouse near the neck was removed to expose 3*3cm 2 The skin of each group of mice was then placed in a breeding cage (a cage-type breeding cage covered with mesh), and 20-30 female mosquitoes (purchased from Rachel Testing, 24-day-old female adult Aedes albopictus mosquitoes) were released into each breeding cage. The exposed skin of the mice in the breeding cage was observed. If redness and swelling were observed and the mice showed scratching behavior, the mice were taken out and the ointment was applied. The redness and swelling subsided and the time when the mice stopped scratching their skin due to mosquito bites (the last scratching without scratching for 15 minutes was the stopping time) was observed. The time from the application of the ointment to the cessation of scratching was recorded as the itching time, and the time from the application of the ointment to the disappearance of the redness and swelling (the diameter of the local redness and swelling was measured with a ruler or compass, and the average diameter of the horizontal and vertical diameters was taken. If the diameter of the redness and swelling was reduced by 80% or more than that during the test, it was recorded as the disappearance of redness and swelling) was recorded as the swelling reduction time.

[0057] The average time for itching and redness to subside was then calculated for each group.

[0058] The mice in the experimental group were smeared with the ointment of Example 2, the mice in the comparative example 1 group were smeared with the ointment of comparative example 1, the mice in the comparative example 2 group were smeared with the ointment of comparative example 2, and the mice in the comparative example 3 group were smeared with the ointment of comparative example 3. The results are shown in Table 1 below.

[0059] Table 1:

[0060] Group Experimental group Comparative Example 1 Comparative Example 2 Comparative Example 3 Anti-itching time (min) 12.57 18.11 26.54 51.61 Swelling reduction time (h) 8.69 16.83 19.25 31.81

[0061] From this, it can be seen that when the weight ratio of mint to mugwort is 1:1, the time for reducing swelling and relieving itching is the shortest, and the effect of reducing swelling and relieving itching is the fastest.

[0062] Typical cases:

[0063] Case 1: Hu Moumou, female, 31 years old, developed a 1cm*1cm red and swollen lump on her left forearm after a mosquito bite, accompanied by itching and discomfort, no skin damage, and no pain. After applying the ointment of Example 1, the itching was significantly relieved after about 8 minutes, and the redness and swelling subsided.

[0064] Case 2: Lu, a female, developed multiple red spots all over her body after being bitten by mosquitoes, accompanied by itching and discomfort, no skin damage, and no pain. After applying the ointment of Example 2, the itching was significantly relieved after about 6 minutes, and the redness and swelling subsided compared to before.

[0065] Case 3: Huo, a female, developed a large red patch of skin, approximately 5cm x 5cm, on her left upper arm after being bitten by a mosquito. It was accompanied by itching and discomfort, but scratching did not cause any damage. After applying the ointment of Example 2, the itching disappeared within about 8 minutes, and the redness and swelling subsided.

[0066] Case 4: Xiang, male, 8 years old, had a red spot on his left forehead after being bitten by a mosquito, about 1cm*1cm in size, accompanied by itching but no redness. After applying the ointment of Example 2, the itching disappeared after 6 minutes.

[0067] The present invention and its embodiments are described above. Such description is not restrictive. The embodiment shown in the embodiment is only one embodiment of the present invention, and the actual structure is not limited thereto. In short, if a person skilled in the art is inspired by the above, and does not deviate from the purpose of the invention, without creatively designing a structure and embodiment similar to the technical solution, they shall fall within the scope of protection of the present invention.

Claims

1. A composition for relieving itching and swelling, characterized in that: The invention comprises 5-50 parts of mint and 5-50 parts of wormwood by weight.

2. The composition for relieving itching and swelling according to claim 1, characterized in that: It also includes at least two of the following ingredients by weight: 5-50 parts of Artemisia annua, 5-50 parts of honeysuckle, 5-20 parts of rosemary, 2-10 parts of angelica dahurica, 5-20 parts of perilla, 5-20 parts of jasmine, 5-30 parts of gynostemma pentaphyllum, and 5-20 parts of citronella.

3. The composition for relieving itching and swelling according to claim 2, characterized in that: By weight, it is composed of the following raw materials in parts by weight: 5-50 parts of Artemisia argyi, 5-50 parts of honeysuckle, 5-20 parts of rosemary, 5-20 parts of honeysuckle, 2-10 parts of Angelica dahurica, 5-20 parts of Perilla frutescens, 5-20 parts of jasmine, 5-30 parts of Gynostemma pentaphyllum, 5-20 parts of citronella, 5-50 parts of mint, and 5-50 parts of wormwood.

4. The composition for relieving itching and swelling according to claim 2, characterized in that: By weight, it is composed of the following raw materials in parts by weight: 5-50 parts of honeysuckle, 5-20 parts of rosemary, 5-20 parts of perilla, 2-10 parts of angelica dahurica, 5-20 parts of jasmine, 5-50 parts of mint, and 5-50 parts of wormwood.

5. The composition for relieving itching and swelling according to claim 3 or 4, characterized in that: The weight ratio of mint to mugwort is 1:

1.

6. Use of the antipruritic and anti-swelling composition according to any one of claims 1 to 5 in the preparation of a preparation for relieving redness, swelling and itching caused by mosquito bites.

7. An antipruritic and anti-swelling ointment, characterized in that: The composition is prepared from the antipruritic and detumescent composition according to any one of claims 1 to 5 and a medically acceptable adjuvant.

8. The antipruritic and detumescent ointment according to claim 7, characterized in that: Its preparation comprises the following steps: 1) taking the raw material components of the composition in proportion, drying them, and then crushing them; 2) adding the crushed material into base oil, the base oil at least immersing the material, and then soaking for 1-24 hours; 3) Wrap the impregnated material with plastic wrap, steam it for 1.5-3 hours, cool it, squeeze the material, squeeze out the liquid, let it stand for 1-24 hours, and then take the upper liquid; 4) Add beeswax and wormwood ash to the above liquid, heat the beeswax until it is completely melted, stir, and wait for it to cool and solidify into a paste.

9. The antipruritic and detumescent ointment according to claim 8, characterized in that: In step 4), after the beeswax is completely melted, vitamin E is added under stirring, and the paste is cooled and solidified.

10. The antipruritic and detumescent ointment according to claim 8, characterized in that: The base oil in step 3) is selected from olive oil or camellia oil.