Blocking guide wire and thrombolysis catheter device

Abstract

The embodiment of the invention provides a plugging guide wire and a thrombolysis catheter device. The plugging guide wire comprises a core wire, an identification tube body and a plugging head. The far end of the core wire is connected with a plugging head, the marking pipe body is arranged on the portion, close to the far end, of the core wire in a sleeving mode, the marking pipe body is fixedly connected with the core wire, and the axial end of the marking pipe body is provided with a first developing marking part; under the condition that the plugging guide wire penetrates through the catheter body of the thrombolysis catheter device, the inner cavity of the marking catheter body can be communicated with a liquid injection pipeline of a joint of the thrombolysis catheter device; wherein at least part of the marking tube body can cover part of the lateral drug delivery area of the catheter body, the first developing marking part is used for being matched with a second developing marking part arranged at the axial end of the lateral drug delivery area of the catheter body, and the distance between the first developing marking part and the second developing marking part is measured; the length of an uncovered lateral drug delivery area is defined.

Description

Technical Field

[0001] The embodiments of the present application relate to the field of medical device technology, and more specifically, to an occlusion guidewire and thrombolytic catheter device. Background Art

[0002] Catheter-directed thrombolysis (abbreviated as catheter-directed thrombolysis) is a method for treating intravascular thrombosis. This method uses a thrombolytic catheter to directly infuse high-concentration thrombolytic drugs around the thrombus to dissolve the thrombus and achieve the treatment purpose.

[0003] Currently, clinically used thrombolytic catheters come in a variety of effective lengths. For example, the effective length of the perfusion segment of a common side-port thrombolytic catheter is typically set between 5 cm and 50 cm, with increments of 5 cm. When performing catheter-directed thrombolysis, physicians need to select a thrombolytic catheter that matches the patient's actual intravascular clot length.

[0004] During local thrombolytic therapy, the length of thrombi within patients' blood vessels usually varies greatly from person to person. However, the drug injection length of an existing thrombolytic catheter is fixed and cannot be adjusted. When the effective length of the perfusion section of the thrombolytic catheter does not match the length of the thrombus, the drug cannot be accurately applied to the thrombus site, resulting in drug waste. At the same time, excess thrombolytic drugs will cause unnecessary drug irritation damage to blood vessels without thrombus, increasing the risk of bleeding complications in patients and posing a potential threat to their health.

[0005] In view of this, it is necessary to provide a new technical solution to solve the above technical problems. Summary of the Invention

[0006] The purpose of this application is to provide a new technical solution for an occlusion guidewire and a thrombolytic catheter device.

[0007] In a first aspect, an embodiment of the present application provides a blocking guidewire, which is applied to a thrombolytic catheter device and comprises: a core wire, a marking tube body, and a blocking head;

[0008] The distal end of the core wire is connected to the plugging head, the marking tube body is sleeved on the distal end of the core wire, and the marking tube body is fixedly connected to the core wire, and the axial end of the marking tube body is provided with a first developing marking portion;

[0009] When the blocking guidewire passes through the catheter body of the thrombolytic catheter device, the inner cavity of the marking tube body can be communicated with the injection pipe of the connector of the thrombolytic catheter device;

[0010] In which, at least part of the marking tube body can cover part of the lateral dosing area of the catheter body, and the first developing marking portion is used to cooperate with the second developing marking portion set at the axial end of the lateral dosing area of the catheter body, and the distance between the first developing marking portion and the second developing marking portion is measured to limit the length of the uncovered lateral dosing area.

[0011] Optionally, the marking tube body includes a first cavity and a second cavity located outside the first cavity, the first cavity is fixedly connected to the core wire, and the second cavity is used to communicate with the injection pipe of the connector of the thrombolytic catheter device.

[0012] Optionally, the core wire includes a core body and an elastic connecting portion, one end of the elastic connecting portion is connected to the blocking head, and the other end of the elastic connecting portion is connected to the distal end of the core wire body.

[0013] Optionally, the occlusion guidewire further includes a fixed connection portion, which is arranged at the proximal end of the core body; the fixed connection portion is configured to be connectable to an adjustment connector of the connector of the thrombolytic catheter device, and the adjustment connector is configured to drive the fixed connection portion to be displaced along the axial direction of the thrombolytic catheter device to adjust the length of the marking tube body covering the lateral drug administration area.

[0014] Optionally, when the blocking guidewire passes through the catheter body, the outer wall of the marking tube body is in contact with the inner wall of the catheter body.

[0015] Optionally, a first connecting portion and a second connecting portion are provided inside the marking tube body, and the marking tube body is fixedly connected to the core wire via the first connecting portion and the second connecting portion.

[0016] In a second aspect, an embodiment of the present application further provides a thrombolytic catheter device, wherein the thrombolytic catheter device comprises the occlusion guidewire as described in the first aspect.

[0017] Optionally, the thrombolytic catheter device further comprises: a catheter body and a connector;

[0018] The proximal end of the catheter body is connected to the connector, and a plurality of side holes are opened on the side wall of the catheter body near the distal end to form the lateral drug delivery area;

[0019] When the blocking guidewire passes through the catheter body, the blocking head blocks the distal end of the catheter body, and the proximal end of the core wire passes through the connector and extends to the outside.

[0020] Optionally, the joint includes a first pipe, the injection pipe and an adjusting connector, and the injection pipe is arranged near the distal end of the first pipe and communicates with the first pipe;

[0021] The adjusting connector is sleeved on the proximal end of the first pipe and connected to the fixed connection part of the occluding guide wire. The adjusting connector can drive the fixed connection part to move along the axial direction of the thrombolytic catheter device to adjust the length of the marking tube body covering the lateral drug administration area.

[0022] Optionally, when the fixed connection portion moves toward the distal direction, the elastic connection portion of the blocking guidewire is compressed, and the elastic connection portion and the blocking head jointly block the distal end of the catheter body.

[0023] One of the technical effects of this application is:

[0024] An embodiment of the present application provides an occlusion guidewire, which includes an identification tube body. When the identification tube body is assembled, at least a portion of the identification tube body will cover a portion of the lateral drug delivery area of the catheter body. At this time, the first developing identification portion on the identification tube body will work in conjunction with the second developing identification portion provided at the axial end of the lateral drug delivery area of the catheter body. By using the spacing between the two developing identification portions, the user can accurately define the length of the lateral drug delivery area not covered by the identification tube body. This not only improves the accuracy of treatment, but also helps reduce drug stimulation and damage to non-target vascular areas, further improving the safety and effectiveness of thrombolytic therapy.

[0025] Other features and advantages of the present specification will become apparent from the following detailed description of exemplary embodiments of the present specification with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the specification and, together with the description, serve to explain the principles of the specification.

[0027] Figure 1 Shown is a schematic diagram of the connection structure of a catheter body and a connector in the prior art.

[0028] Figure 2 The figure shows the structure of the occlusion guide wire provided in the embodiment of the present application. Figure 1 .

[0029] Figure 3 The diagram shows the structure of the thrombolytic catheter device provided in the embodiment of the present application. Figure 1 .

[0030] Figure 4 The figure shows the structure of the occlusion guide wire provided in the embodiment of the present application. Figure 2 .

[0031] Figure 5 Shown Figure 4 Cross-sectional view at AA in the middle.

[0032] Figure 6 The diagram shows the structure of the thrombolytic catheter device provided in the embodiment of the present application. Figure 2 .

[0033] Description of reference numerals:

[0034] 1. Occluding guidewire; 10. Core wire; 101. Core body; 102. Elastic connecting portion; 11. Marking tube; 110. First developing marking portion; 111. First cavity; 112. Second cavity; 113. First connecting portion; 114. Second connecting portion; 12. Occluding head; 13. Fixed connecting portion;

[0035] 2. Catheter body; 20. Lateral drug delivery area; 21. Second imaging marker; 22. Catheter connection;

[0036] 3. Joint; 31. First pipeline; 32. Liquid injection pipeline; 321. Liquid injection port; 322. Liquid outlet; 33. Rotary joint; 34. Adjustable connector; 35. Sealing gasket; DETAILED DESCRIPTION

[0037] Various exemplary embodiments of the present application will now be described in detail with reference to the accompanying drawings. It should be noted that unless otherwise specifically stated, the relative arrangements of components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present application.

[0038] The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the present disclosure, its application, or uses.

[0039] Techniques and equipment known to ordinary technicians in the relevant art may not be discussed in detail, but where appropriate, the techniques and equipment should be considered part of the specification.

[0040] In all examples shown and discussed herein, any specific values should be interpreted as merely exemplary and not limiting. Therefore, other examples of the exemplary embodiments may have different values.

[0041] It should be noted that like reference numerals and letters refer to like items in the following figures, and therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

[0042] The present invention provides an occlusion guidewire 1, which is specifically used in a thrombolytic catheter device. The thrombolytic catheter device also includes a catheter body 2 and a connector 3. During use, the distal end of the occlusion guidewire 1 passes through the catheter body 2, and the proximal end of the occlusion guidewire 1 passes through the connector 3 and extends to the connector 3.

[0043] Usually, refer to Figure 1 In the thrombolytic catheter device, the proximal end of the catheter body 2 is connected to a connector 3, and the side wall of the catheter body 2 near the distal end is provided with a plurality of side holes for drug administration, which form a lateral drug administration area 20. A blocking guidewire 1 is disposed within the catheter body 2. The blocking guidewire 1 includes a core wire 10 and a blocking head 12 disposed at the distal end of the core wire 10. The blocking head 12 blocks the distal end of the catheter body 2. The proximal end of the core wire 10 passes through the connector 3, which facilitates adjustment of the telescopic position of the core wire 10 relative to the catheter body 2, thereby controlling the switching between a sealed contact state and a separated state between the blocking head 12 and the distal end of the catheter body 2.

[0044] For example, referring to Figure 2 、 Figure 3 、 Figure 4 and Figure 6 The plug 12 includes a plug body and a guide coil spring. The guide coil spring can guide the core wire 10. The plug body is disposed at the end of the guide coil spring near the distal end of the catheter body 2. The plug body can be disposed within the catheter body 2 to block the distal end of the catheter body 2 and prevent the drug solution in the catheter body 2 from flowing out of the distal end of the catheter body 2 and affecting the pressure of the drug solution in the catheter body 2.

[0045] The embodiment of the present application improves the structure of the occluding guidewire 1 so that the improved occluding guidewire 1, when used in conjunction with the catheter body 2, can change the length of the lateral drug administration area 20 of the catheter body 2, specifically shorten the length of the lateral drug administration area 20, so that the adjusted length of the lateral drug administration area 20 can match the length of the patient's thrombus, thereby achieving the purpose of spraying the drug on the thrombus in a targeted manner, avoiding drug irritation damage to the blood vessel parts without thrombus, and reducing the probability of bleeding complications.

[0046] In the examples of this application, refer to Figure 1 、 Figure 2 、 Figure 4 and Figure 6 The occluding guidewire 1 includes: a core wire 10 , a marking tube body 11 and a occluding head 12 .

[0047] The distal end of the core wire 10 is connected to the blocking head 12 , the marking tube body 11 is sleeved on the distal end of the core wire 10 , and the marking tube body 11 is fixedly connected to the core wire 10 , and the axial end of the marking tube body 11 is provided with a first developing marking portion 110 .

[0048] When the blocking guidewire 1 passes through the catheter body 2 of the thrombolytic catheter device, the inner cavity of the marking tube 11 can be communicated with the injection pipe 32 of the connector 3 of the thrombolytic catheter device.

[0049] In which, at least part of the marking tube body 11 can cover part of the lateral dosing area 20 of the catheter body 2, and the first developing marking portion 110 is used to cooperate with the second developing marking portion 21 set at the axial end of the lateral dosing area 20 of the catheter body 2, and the distance between the first developing marking portion 110 and the second developing marking portion 21 is measured to limit the length of the uncovered lateral dosing area 20.

[0050] In the examples of this application, refer to Figure 1 、 Figure 2 、 Figure 4 and Figure 6 The occluding guidewire 1 mainly consists of three parts: a core wire 10, a marking tube 11, and a occluding head 12. The distal end of the core wire 10 is tightly connected to the occluding head 12, for example, the core wire 10 and the occluding head 12 are connected by welding. Exemplarily, the core wire 10 and the occluding head 12 are connected by laser welding.

[0051] During use, the core wire 10 is used to penetrate the catheter body 2 of the thrombolytic catheter device, and the blocking head 12 is used to block the distal end of the catheter body 2 in the thrombolytic catheter device.

[0052] In this embodiment of the present application, the marker tube 11 is positioned over the distal end of the core wire 10 and is securely fastened thereto. A first imaging marker 110 is provided at the axial end of the marker tube 11 to clearly indicate its position in medical images. The marker tube 11 is a circumferentially sealed tubular structure, preventing liquid from leaking from the sidewalls of the marker tube 11 during drug delivery.

[0053] For example, referring to Figure 2 The marking tube 11 can be made of a deformable elastic tube, such as a spring tube. In actual application, when the occluding guidewire 1 penetrates the blood vessel during operation, the marking tube 11, with its excellent elasticity, can flexibly conform to the curvature of the blood vessel, always maintaining adaptability to the vascular environment, ensuring smooth and accurate operation.

[0054] For example, the marking tube body 11 has a specific preset length, which is determined in advance during the design phase. In addition, the marking tube body 11 provides a variety of different specifications and models for selection, and the marking tube bodies 11 of different specifications and models have different lengths.

[0055] During actual clinical application, users need to comprehensively consider the length of the thrombus in the patient and the original length of the lateral drug delivery region 20 in the catheter body 2. Based on this key information, users can select the appropriate marking tube 11 from a variety of specifications and models. This selection allows the effective length of the lateral drug delivery region 20 to be adjusted to match the length of the patient's thrombus. This allows the drug to be precisely sprayed onto the thrombus site during treatment, achieving targeted treatment of the thrombus and effectively preventing unnecessary irritation and damage to normal blood vessels without thrombus formation, thereby significantly reducing the risk of bleeding complications.

[0056] For example, referring to Figure 2 The marking tube body 11 can be fixedly connected to the core wire 10 by bonding or other methods.

[0057] Exemplarily, the marking tube body 11 has two axial ends, and the first developing marking portion 110 is provided at at least one of the two axial ends.

[0058] For example, the first developing marking portion 110 is provided at the proximal axial end of the marking tube body 11. Alternatively, the first developing marking portion 110 is provided at the distal axial end of the marking tube body 11. Alternatively, the first developing marking portion 110 is provided at both the proximal axial end and the distal axial end of the marking tube body 11.

[0059] Exemplarily, the first development marking portion 110 is a development ring.

[0060] In the embodiment of the present application, the marker tube 11 is sleeved over the portion of the core wire 10 near the distal end, primarily because in the catheter body 2, the region near the distal end of the catheter body 2 generally forms a lateral medication region 20. When the marker tube 11 is sleeved over the portion of the core wire 10 near the distal end, when the occluding guidewire 1 and the catheter body 2 are used in conjunction, at least a portion of the marker tube 11 can cover a portion of the lateral medication region 20, thereby varying the length of the lateral medication region 20.

[0061] In an embodiment of the present application, when the blocking guidewire 1 passes through the catheter body 2 of the thrombolytic catheter device, the internal chamber of the marking tube body 11 can be smoothly connected with the injection pipe 32 of the connector 3 of the thrombolytic catheter device, thereby ensuring that the drug solution or contrast agent can be smoothly injected.

[0062] For example, in actual clinical practice, the user would inject liquid medicine through the injection port 321 provided on the injection channel 32 of the connector 3. Once the liquid medicine enters the injection channel 32, it flows in an orderly manner along a predetermined path, passing through the catheter body 2 and the marking tube 11 in sequence, and ultimately reaching the lateral drug delivery area 20 not covered by the marking tube 11. There, the medicine is precisely sprayed to ensure that the medicine acts directly on the target thrombus site.

[0063] Alternatively, when the marker tube 11 is longer, its proximal end can fit snugly against the distal end of the connector 3, seamlessly connecting them. In this state, when the user injects liquid medicine through the injection port 321 of the injection channel 32, the liquid medicine flows smoothly along the injection channel 32, directly passing through the marker tube 11, and precisely reaching the lateral drug delivery area 20 not covered by the marker tube 11, where it is sprayed, ensuring that the medicine is precisely applied to the target thrombus location.

[0064] Therefore, in the embodiment of the present application, when the marker tube 11 is assembled, at least a portion of the marker tube 11 will cover a portion of the lateral drug delivery region 20 of the catheter body 2. At this point, the first visible marker 110 on the marker tube 11 will work in conjunction with the second visible marker 21 provided at the axial end of the lateral drug delivery region 20 of the catheter body 2. By using the spacing between these two visible markers, the user can accurately define the length of the lateral drug delivery region 20 not covered by the marker tube 11. This not only improves treatment accuracy but also helps reduce drug irritation and damage to non-target vascular areas, further enhancing the safety and effectiveness of thrombolytic therapy.

[0065] Exemplarily, the lateral administration region 20 has two axial ends, and a second development marking portion 21 is provided at any of the two axial ends. For example, the second development marking portion 21 may be a development ring.

[0066] In the specific embodiments of this application, refer to Figure 4 and Figure 5 The marking tube body 11 includes a first cavity 111 and a second cavity 112 located outside the first cavity 111. The first cavity 111 is fixedly connected to the core wire 10, and the second cavity 112 is used to communicate with the injection pipe 32 of the connector 3 of the thrombolytic catheter device.

[0067] In this embodiment, the marking tube body 11 is designed as a multi-chamber tube body, and each chamber has a different division of labor. Specifically, the marking tube body 11 includes a first cavity 111 and a second cavity 112. The first cavity 111 is the inner cavity of the marking tube body 11, and the second cavity 112 is the outer cavity of the marking tube body 11. The core wire 10 of the occluding guidewire 1 passes through the first cavity 111 and is fixedly connected to the first cavity 111. During use, the second cavity 112 is connected to the injection pipe 32 of the connector 3 of the thrombolytic catheter device, thereby providing an effective channel for the delivery of the drug solution.

[0068] In this embodiment, the core wire 10 is passed through the first lumen 111 and fixedly connected. The multi-chamber structure provides a more stable support and fixation environment for the core wire 10. Compared with a single-chamber structure, the multi-chamber structure can disperse the stress on the core wire 10, reduce the shaking and displacement of the core wire 10 when it moves or bends within the blood vessel, ensure the stability of the overall structure of the occlusion guidewire 1, and reduce the treatment risks caused by structural instability.

[0069] In the specific embodiments of this application, refer to Figure 6 The core wire 10 includes a core body 101 and an elastic connecting portion 102 , one end of the elastic connecting portion 102 is connected to the plugging head 12 , and the other end of the elastic connecting portion 102 is connected to the distal end of the core wire 10 body.

[0070] In this embodiment, the core wire 10 consists of a core body 101 and an elastic connector 102. The elastic connector 102 exhibits excellent elastic deformation and connection properties. Specifically, one end of the elastic connector 102 can be securely welded to the plug 12, while the other end can be reliably welded to the distal end of the core body 101. Alternatively, the elastic connector 102 and the core body 101 can be manufactured using an integral molding process, ensuring a tight connection and structural stability.

[0071] For example, the elastic connection portion 102 may be designed as a spring connection segment. This structural form can give it good elastic deformation capability.

[0072] In actual application scenarios, the proximal end of the core body 101 can smoothly pass through the connector 3 of the thrombolytic catheter device and extend to the outside of the connector 3, so that the user can perform related operations. Since the core body 101 is connected to the elastic connecting portion 102, when the user moves the core wire 10 along the axial direction of the thrombolytic catheter device, the elastic connecting portion 102 will undergo elastic deformation. In this process, the position of the marking tube body 11 relative to the lateral drug administration area 20 of the catheter body 2 will be dynamically adjusted with the help of the deformation of the elastic connecting portion 102. By continuously moving the core wire 10 in the axial direction, the user can accurately and precisely control the relative position of the marking tube body 11 and the lateral drug administration area 20 in real time, and then flexibly adjust the length of the lateral drug administration area 20 not covered by the marking tube body 11, so that the length of the adjusted lateral drug administration area 20 can match the length of the patient's thrombus, thereby achieving the purpose of spraying the thrombus in a targeted manner, avoiding drug irritation damage to the vascular area without thrombus, and reducing the probability of bleeding complications.

[0073] When the user moves the core wire 10 along the axial direction of the thrombolytic catheter device, the elastic connecting portion 102 will be deformed and stretched. In this case, the position of the marking tube body 11 will change with the help of the deformation of the elastic connecting portion 102. If the marking tube body 11 is arranged closer to the proximal end of the lateral drug administration area 20, the lateral drug administration area 20 not covered by the marking tube body 11 will be longer. This structural layout can well adapt to longer thrombi, ensuring that the drug solution can be accurately and fully sprayed on the longer thrombus area, meeting the drug solution delivery requirements for thrombolytic treatment of long thrombi.

[0074] Conversely, when the user moves the core wire 10 along the axial direction of the thrombolytic catheter device, the elastic connector 102 is compressed, and the marker tube 11, due to the deformation of the elastic connector 102, is positioned closer to the distal end of the lateral drug delivery region 20. At this point, the lateral drug delivery region 20 not covered by the marker tube 11 is shorter. This structural layout precisely matches shorter thrombi, allowing the drug solution to act concentratedly and efficiently on the short thrombus site, achieving precise thrombolytic therapy for short thrombi.

[0075] In this embodiment, it should also be emphasized that the elastic connecting portion 102 is provided at the distal end of the core body 101, so that the elastic connecting portion 102 can be directly connected to the blocking head 12. In use, the blocking head body of the blocking head 12 can be located outside or inside the catheter body 2 in the thrombolytic catheter device to achieve the purpose of blocking the distal end of the catheter body 2. At the same time, the elastic connecting portion 102 is located inside the catheter body 2. When the elastic connecting portion 102 is in a compressed state, the compression force generated by the compression will directly act on the distal end of the catheter body 2, thereby cooperating with the blocking head body of the blocking head 12, effectively enhancing the sealing performance of the end, preventing leakage of the drug solution, and ensuring the smooth progress of thrombolytic therapy.

[0076] In the specific embodiments of this application, refer to Figure 6 , the occluding guidewire 1 further includes a fixed connection portion 13, and the fixed connection portion 13 is provided at the proximal end of the core body 101;

[0077] The fixed connection portion 13 is configured to be connectable to the adjustment connection head 34 of the connector 3 of the thrombolytic catheter device, and the adjustment connection head 34 is configured to drive the fixed connection portion 13 to move along the axial direction of the thrombolytic catheter device to adjust the length of the marking tube body 11 covering the lateral medication area 20.

[0078] In this embodiment, the occluding guidewire 1 further includes a fixed connection portion 13. In actual clinical application scenarios, the fixed connection portion 13 is used to connect to the adjustment connector 34 at the joint 3 of the thrombolytic catheter device. When the thrombolytic catheter device drives the fixed connection portion 13 to move along the axial direction of the thrombolytic catheter device with the adjustment connector 34, the user can accurately control the core wire 10 to move along the axial direction of the thrombolytic catheter device. When the core wire 10 moves axially, with the aid of the elastic connection portion 102, the core wire 10 will drive the position of the marker tube body 11 connected thereto to change, and then adjust the area range of the marker tube body 11 covering the lateral drug administration area 20 in real time. As the coverage area of the marker tube body 11 changes dynamically, the length of the uncovered lateral drug administration area 20 will also change accordingly. This flexible length adjustment scheme can fully meet the thrombolytic treatment needs of thrombi of different lengths, and ensure that the drug solution can accurately and effectively act on the target thrombus site.

[0079] Specifically, during actual operation, the adjusting connector 34 can be moved along the axial direction of the thrombolytic catheter device by sliding or rotating. For example, the adjusting connector 34 is provided with a thread, and the fixed connection part 13 is connected to the adjusting connector 34 by a threaded manner. By rotating the adjusting connector 34 of the joint 33, the adjusting connector 34 drives the fixed connection part 13 to move along the axial direction of the thrombolytic catheter device. With the help of the elastic connection part 102, the movement of the fixed connection part 13 causes the core wire 10 to be displaced as a whole along the axial direction of the thrombolytic catheter device. This displacement will drive the corresponding position change of the marker tube body 11 relative to the lateral drug administration area 20, and then accurately adjust the area of the marker tube body 11 covering the lateral drug administration area 20. As the coverage area of the marker tube body 11 changes, the length of the uncovered lateral drug administration area 20 will also change accordingly, thereby meeting the demand for precise control of the length of the drug injection area under different treatment scenarios.

[0080] In the specific embodiments of this application, refer to Figure 3 and Figure 6 When the blocking guidewire 1 passes through the catheter body 2 , the outer wall of the marking tube 11 fits with the inner wall of the catheter body 2 .

[0081] In this embodiment, during operation of the thrombolytic catheter device, the drug solution needs to be delivered to the target thrombus location through the catheter body 2 and the marker tube 11. When the outer wall of the marker tube 11 is in contact with the inner wall of the catheter body 2, there is almost no gap between them, forming an effective sealing barrier. This prevents the drug solution from leaking from the contact area between the marker tube 11 and the catheter body 2 during delivery. This ensures that the drug solution can reach the thrombus location along the preset path, improves the utilization rate of the drug solution, and avoids drug waste and the adverse effects that drug leakage may cause on surrounding normal tissues.

[0082] In the specific embodiments of this application, refer to Figure 2 The marking tube body 11 is internally provided with a first connecting portion 113 and a second connecting portion 114 , and the marking tube body 11 is fixedly connected to the core wire 10 via the first connecting portion 113 and the second connecting portion 114 .

[0083] For example, the first connecting portion 113 and the second connecting portion 114 may be adhesive portions. The marking tube body 11 is fixedly connected to the core wire 10 by adhesive bonding.

[0084] For example, the first connection portion 113 and the second connection portion 114 may be welding portions. The marking tube body 11 is fixedly connected to the core wire 10 by welding.

[0085] The present application also provides a thrombolytic catheter device. Figure 3 and Figure 6 The thrombolytic catheter device includes the occlusion guidewire 1 as described above.

[0086] In an embodiment of the present application, a thrombolytic catheter device is provided, which implements catheter-directed thrombolysis. The occlusion guidewire 1 provided in the embodiment of the present application is applied to the thrombolytic catheter device. The length of the lateral drug delivery region 20 of the catheter body 2 in the thrombolytic catheter device can be adjusted, thereby ensuring more precise and efficient thrombolytic therapy and meeting diverse clinical treatment needs to the greatest extent possible.

[0087] In the specific embodiments of this application, refer to Figure 3 and Figure 6 , the thrombolytic catheter device further comprises: a catheter body 2 and a connector 3;

[0088] The proximal end of the catheter body 2 is connected to the connector 3, and a plurality of side holes are opened on the side wall of the catheter body 2 near the distal end to form the lateral drug delivery area 20;

[0089] When the blocking guidewire 1 passes through the catheter body 2 , the blocking head 12 blocks the distal end of the catheter body 2 , and the proximal end of the core wire 10 passes through the connector 3 and extends to the outside.

[0090] In this embodiment, the thrombolytic catheter device further comprises a catheter body 2 and a connector 3. The catheter body 2 is made of a polymer material. The connector 3 may be a Y-shaped valve.

[0091] The catheter body 2 is provided with a plurality of side holes near the distal end to form a lateral drug administration region 20. The proximal end of the catheter body 2 is connected to the connector 3, specifically, the proximal end of the catheter body 2 is connected to the connector 3 via a catheter connector 22.

[0092] During use, the blocking head 12 of the blocking guidewire 1 blocks the distal end of the catheter body 2 to prevent liquid medicine from leaking from the distal end of the catheter body 2. The proximal end of the core wire 10 passes through the connector 3 and extends to the outside, making it easy for the user to operate the core wire 10.

[0093] Usually, refer to Figure 1 The connector 3 may include a first pipe 31, an injection pipe 32 arranged near the distal end of the first pipe 31, and a rotary joint 33 arranged at the proximal end of the first pipe 31. The core wire 10 passes through the first pipe 31 and the rotary joint 33 and extends to the outside of the connector 3. The injection pipe 32 includes an injection port 321 and a liquid outlet 322, and the injection port 321 is connected to an external device to achieve injection. During use, the drug solution passes through the injection pipe 32, the first pipe 31, the catheter body 2 and the marking tube 11 to reach the lateral drug delivery area 20 not covered by the marking tube 11, thereby spraying the drug to the target thrombus.

[0094] For example, during clinical operation, after the user adjusts the relative position of the marker tube 11 to the lateral drug administration area 20 to the ideal state, the core wire 10 can be locked and fixed by the rotary joint 33. This design can effectively prevent the core wire 10 from shifting during subsequent operations, ensuring that the relative position between the marker tube 11 and the lateral drug administration area 20 remains stable, providing a strong guarantee for the accuracy and reliability of thrombolytic therapy.

[0095] In addition, the connector 3 may further include a sealing gasket 35, which is provided at the proximal end of the first pipe 31. The sealing gasket 35 effectively seals the proximal end of the connector 3 to prevent the thrombolytic drug from flowing out of the proximal end of the connector 3. For example, the sealing gasket 35 may be a silicone gasket.

[0096] It should be noted that Figure 1 The functions and component characteristics of the illustrated connector 3 are well known to those skilled in the medical device field. Specifically, connector 3 features a liquid injection function, enabling smooth liquid injection; it provides a reliable connection with catheter body 2, ensuring overall structural stability; and it also locks core wire 10, ensuring precise positioning of core wire 10 during operation. Furthermore, connector 3 includes key components such as a sealing gasket 35. These design features are conventional in the medical device field and will not be further elaborated upon here.

[0097] In the specific embodiments of this application, refer to Figure 6 This embodiment improves the traditional connector structure so that the connector can cooperate with the core wire 10 to adjust the axial displacement of the core wire 10.

[0098] Specifically, refer to Figure 6The joint 3 includes a first pipe 31, an injection pipe 32 and an adjusting connector 34. The injection pipe 32 is provided near the distal end of the first pipe 31 and communicates with the first pipe 31.

[0099] The adjusting connector 34 is sleeved on the proximal end of the first pipe 31 and connected to the fixed connection part 13 of the occluding guide wire 1. The adjusting connector 34 can drive the fixed connection part 13 to move along the axial direction of the thrombolytic catheter device to adjust the length of the marking tube body covering the lateral drug administration area 20.

[0100] In this embodiment, some components of the connector 3 are improved. For example, the rotary connector 33 in the conventional connector 3 can be improved to an adjustable connector 34, which is connected to the fixed connector 13 located at the proximal end of the core wire 10. For example, the fixed connector 13 is disposed within the first conduit 31, and a notch is provided in the first conduit 31 along its radial direction to expose at least a portion of the fixed connector 13. The exposed fixed connector 13 is connected to the adjustable connector 34.

[0101] In this embodiment, the adjustable connector 34 drives the connected fixed connection portion 13 to move axially along the thrombolytic catheter device. This displacement adjustment design allows precise adjustment of the length of the marker tube covering the lateral medication area 20, thereby meeting the treatment requirements for clots of varying lengths and ensuring the accuracy and effectiveness of thrombolytic therapy.

[0102] For example, referring to Figure 6 The adjustable connector 34 is mounted on the rear (proximal) end of the connector 3. Adjustment threads are located above and below the fixed connector 13. These threads extend through the recess (notch) at the rear end of the first pipe 31 and threadably engage the inner wall of the adjustable connector 34. Rotating the adjustable connector 34 allows the fixed connector 13 to move forward and backward.

[0103] Or illustratively, the adjusting connector 34 is fastened to the fixed connection part 13 by bonding or welding, and the adjusting connector 34 can slide relative to the first pipe 31. When the adjusting connector 34 slides relative to the first pipe 31, the adjusting connector 34 drives the fixed connection part 13 to move forward and backward.

[0104] It should be noted that in the scheme where the adjustable connector 34 can slide relative to the first tube 31, the handle of the thrombolytic catheter device will become longer or shorter, which may affect the user's operating experience. Preferably, the front and rear movement of the fixed connection part 13 is achieved by rotating the adjustable connector 34.

[0105] In the specific embodiments of this application, refer to Figure 6When the fixed connection part 13 moves toward the distal direction, the elastic connection part 102 of the blocking guidewire 1 is compressed, and the elastic connection part 102 and the blocking head 12 jointly block the distal end of the catheter body 2.

[0106] In this embodiment, when the fixed connection part 13 moves toward the distal direction, the elastic connection part 102 of the occluding guide wire 1 will be compressed by the axial force. This compression state is not a simple deformation, but a dynamic adjustment based on the elastic characteristics of the elastic connection part 102 itself.

[0107] During compression, the elastic connector 102 and the plugging head 12 work closely together to seal the distal end of the catheter body 2. This sealing method is not a single physical barrier, but rather forms a stable and reliable sealing structure through the elastic deformation of the elastic connector 102 and its cooperation with the plugging head 12. It can further effectively prevent the leakage of liquid medicine from the distal end of the catheter body 2, ensuring the accuracy and safety of the thrombolytic catheter device during operation.

[0108] The above embodiments focus on the differences between the various embodiments. As long as the different optimization features between the various embodiments are not contradictory, they can be combined to form a better embodiment. Considering the simplicity of the text, they will not be repeated here.

[0109] Although some specific embodiments of the present application have been described in detail by way of example, it should be understood by those skilled in the art that the above examples are for illustration only and are not intended to limit the scope of the present application. It should be understood by those skilled in the art that the above examples may be modified without departing from the scope and spirit of the present application. The scope of the present application is defined by the appended claims.

Claims

1. A occlusion guidewire, characterized in that: Applicable to a thrombolytic catheter device, the blocking guidewire comprises: a core wire (10), a marking tube body (11) and a blocking head (12); The distal end of the core wire (10) is connected to the plugging head (12), the marking tube (11) is sleeved on the distal end of the core wire (10), and the marking tube (11) is fixedly connected to the core wire (10), and the axial end of the marking tube (11) is provided with a first developing marking portion (110); When the blocking guide wire passes through the catheter body (2) of the thrombolytic catheter device, the internal cavity of the marking tube (11) can be communicated with the injection pipe (32) of the connector (3) of the thrombolytic catheter device; Wherein, at least a portion of the marking tube body (11) is capable of covering a portion of the lateral drug administration area (20) of the catheter body (2); the first developing marking portion (110) is used to cooperate with the second developing marking portion (21) provided at the axial end of the lateral drug administration area (20) of the catheter body (2); and the length of the uncovered lateral drug administration area (20) is limited by measuring the distance between the first developing marking portion (110) and the second developing marking portion (21).

2. The occlusion guidewire according to claim 1, characterized in that: The marking tube body (11) includes a first cavity (111) and a second cavity (112) located on the periphery of the first cavity (111), the first cavity (111) is fixedly connected to the core wire (10), and the second cavity (112) is used to communicate with the injection pipe (32) of the connector (3) of the thrombolytic catheter device.

3. The occlusion guidewire according to claim 1 or 2, characterized in that: The core wire (10) comprises a core body (101) and an elastic connecting portion (102), one end of the elastic connecting portion (102) is connected to the plugging head (12), and the other end of the elastic connecting portion (102) is connected to the distal end of the core wire (10) body.

4. The occlusion guidewire according to claim 3, characterized in that: The occluding guidewire further comprises a fixed connection portion (13), and the fixed connection portion (13) is arranged at the proximal end of the core body (101); The fixed connection portion (13) is configured to be connected to the adjustment connection head (34) of the joint (3) of the thrombolytic catheter device, and the adjustment connection head (34) is configured to drive the fixed connection portion (13) to move along the axial direction of the thrombolytic catheter device to adjust the length of the marking tube body (11) covering the lateral drug administration area (20).

5. The occlusion guidewire according to claim 1, characterized in that: When the blocking guidewire passes through the catheter body (2), the outer wall of the marking tube body (11) fits into the inner wall of the catheter body (2).

6. The occlusion guidewire according to claim 1, characterized in that: A first connecting portion (113) and a second connecting portion (114) are provided at intervals inside the marking tube body (11), and the marking tube body (11) is fixedly connected to the core wire (10) via the first connecting portion (113) and the second connecting portion (114).

7. A thrombolytic catheter device, characterized in that: The thrombolytic catheter device comprises an occlusion guidewire (1) according to any one of claims 1 to 6.

8. The thrombolytic catheter device according to claim 7, characterized in that: The thrombolytic catheter device further comprises: a catheter body (2) and a connector (3); The proximal end of the catheter body (2) is connected to the connector (3), and a plurality of side holes are opened on the side wall of the catheter body (2) near the distal end to form the lateral drug delivery area (20); When the blocking guidewire passes through the catheter body (2), the blocking head (12) blocks the distal end of the catheter body (2), and the proximal end of the core wire (10) passes through the connector (3) and extends to the outside.

9. The thrombolytic catheter device according to claim 8, characterized in that: The joint (3) comprises a first pipe (31), the injection pipe (32) and an adjusting connector (34); the injection pipe (32) is arranged near the distal end of the first pipe (31) and communicates with the first pipe (31); The adjusting connector (34) is sleeved on the proximal end of the first pipe (31) and connected to the fixed connection portion (13) of the blocking guide wire. The adjusting connector (34) can drive the fixed connection portion (13) to move along the axial direction of the thrombolytic catheter device to adjust the length of the marking tube body (11) covering the lateral drug administration area (20).

10. The thrombolytic catheter device according to claim 9, characterized in that: When the fixed connection part (13) moves toward the distal end, the elastic connection part (102) of the blocking guidewire is compressed, and the elastic connection part (102) and the blocking head (12) jointly block the distal end of the catheter body (2).

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