Non-natural amino acid continuous synthesis reaction device and use method thereof

Abstract

The invention provides a non-natural amino acid continuous synthesis reaction device and a use method, and relates to the technical field of amino acid synthesizing.The non-natural amino acid continuous synthesis reaction device comprises a box body mechanism, a vibration mechanism is installed on the upper portion in the box body mechanism, a quantification mechanism is installed on the lower portion in the box body mechanism, and the box body mechanism comprises a reaction box; according to the technical scheme, when the amino acid needs to be subjected to the fermentation reaction, the two-way screw rod is driven to rotate through the third motor, the two-way screw rod is driven to rotate through the fourth motor, and the two-way screw rod is driven to rotate through the fourth motor; the rotation of the two-way screw rod can drive the connecting block to synchronously move in the opposite direction, so that the baffles are driven to move the two sides of the conveying hole, the conveying hole is exposed, and the amino acid falls into the reaction box, and when the amino acid needs to be subjected to fermentation reaction, the two baffles can be driven to seal the conveying hole by starting the third motor again. Quantitative amino acid can be stored at the bottom of the reaction box.

Description

Technical Field

[0001] The present invention relates to the technical field of amino acid synthesis, and in particular to a non-natural amino acid continuous synthesis reaction device and a use method. Background Art

[0002] Amino acids are organic compounds containing amino groups (-NH4Z) and carboxylic acid groups (-COOH). They are the basic units of protein and are involved in almost all aspects of life activities, including metabolism, immunity, and cell repair. They are divided into two categories: essential amino acids (which cannot be synthesized by the human body) and non-essential amino acids (which can be synthesized by the human body). During the synthesis process, amino acids need to be processed and then fermented.

[0003] Currently, in the prior art, during the fermentation synthesis reaction process of amino acids, since the amino acid raw materials are in powder form, agglomeration occurs during the addition process. On the one hand, this causes inaccurate metering of the amino acid addition, and on the other hand, the agglomerated amino acids cannot fully undergo the fermentation reaction, thereby reducing the amino acid reaction efficiency. Therefore, the present invention provides a continuous synthesis reaction device for non-natural amino acids and a method for use. Summary of the Invention

[0004] The purpose of the present invention is to solve the shortcomings of the prior art in that the amino acid raw material is in powder form and agglomerates during the feeding process, which on the one hand causes inaccurate metering of the amino acid feeding and on the other hand makes it impossible for the agglomerated amino acids to fully undergo fermentation reaction, thereby reducing the efficiency of the amino acid reaction.

[0005] In order to achieve the above-mentioned objectives, the present invention adopts the following technical scheme: a non-natural amino acid continuous synthesis reaction device, comprising a box body mechanism, a vibration mechanism is installed on the upper part of the box body mechanism, a quantitative mechanism is installed on the lower part of the box body mechanism, the box body mechanism comprises a reaction box, one side of the reaction box is connected to a fermentation box, and a humidifying device is installed on one side of the upper surface of the fermentation box; the reaction box is arranged in a trapezoidal shape, a feed inlet is provided on the upper part of the reaction box, a discharge valve is provided on the lower part of the reaction box, a fixed bracket is fixedly connected to the outer side of the reaction box, support legs are fixedly connected to the four corners of the lower surface of the fixed bracket, and a No. 1 partition is fixedly connected to the inner wall of the reaction box.

[0006] In at least some embodiments, the vibration mechanism includes an upper bracket, a lower bracket is provided below the upper bracket, a coarse filter is fixedly connected to the inner side of the upper bracket, a second partition is fixedly connected to the upper inner side of the lower bracket, and a fine filter is fixedly connected to the lower inner side of the lower bracket.

[0007] In at least some embodiments, a connecting bracket is fixedly connected to the outer side of the upper bracket, the connecting bracket is located below the lower bracket, a movable block is fixedly connected to the lower surface of the connecting bracket, an L-shaped connecting block is fixedly connected to the lower surface of the lower bracket away from the connecting bracket, main slide rails are slidably installed at the lower ends of the movable block and the L-shaped connecting block, side fixing rods are fixedly connected to both ends of the main slide rails, and one end of the side fixing rod is fixed to the inner wall of the reaction box.

[0008] In at least some embodiments, a transmission rod is rotatably mounted on one side of the movable block, and a rotating part is rotatably mounted on one end of the transmission rod. Two rotating parts are provided, one of which is rotatably mounted on an L-shaped connecting block, and a No. 1 motor is provided below the L-shaped connecting block. The No. 1 motor is fixed to the upper surface of the No. 1 partition, and the other rotating part is fixed to the output shaft of the No. 1 motor. A connecting rod is rotatably mounted on the same end of the two rotating parts.

[0009] In at least some embodiments, the quantitative mechanism includes two side slides, each of which is fixed to the inner wall of the reaction box, and a side slider is slidably installed in each side slide, one of which is engaged with a threaded rod, and one end of the threaded rod is fixed to a No. 2 motor, and the No. 2 motor is fixed to the inner wall of the reaction box, and the No. 2 motor is located below the No. 1 partition.

[0010] In at least some embodiments, a loading plate is rotatably installed between the two side sliders, a conveying hole is provided in the middle of the loading plate, and a mounting groove is provided on the lower surface of the loading plate. L-shaped limit rods are rotatably installed in the middle of both sides of the loading plate, one end of the L-shaped limit rod is rotatably installed on the inner wall of the reaction box, a transmission connecting rod is rotatably installed below the L-shaped limit rod, a connecting seat is rotatably installed at the lower end of the transmission connecting rod, a sealing partition is fixed to one side of the connecting seat, and the lower end of the sealing partition is rotatably installed at the connection between the reaction box and the fermentation box.

[0011] In at least some embodiments, baffles are provided on both sides of the mounting groove, and connecting blocks are fixed on both sides of each baffle, and each connecting block is installed with a limiting bracket, and the limiting bracket is fixed to the inner wall of the mounting groove. The same end of the two connecting blocks is meshed and connected with a bidirectional screw, and mounting seats are rotatably installed at both ends of the bidirectional screw, and the mounting seat is fixed to the mounting groove, and one end of the bidirectional screw is fixed with a No. 3 motor, and the No. 3 motor is fixed to the mounting seat, and the lower surfaces of the two baffles are fixed with slip rings.

[0012] In at least some embodiments, two sliders are installed in each of the slip rings, one end of the four sliders is rotatably installed with a rotating shaft, the lower ends of the four rotating shafts are fixedly connected to a stirring plate, and the upper ends of the four rotating shafts are fixedly connected to a driven gear, the outer side of the driven gear is meshed with a gear ring, and the gear ring is fixed to the outer wall of the slip ring, the other ends of the four sliders are rotatably installed with a push rod, one end of the push rod on the same side is rotatably installed with a mounting sleeve, the two mounting sleeves are respectively fixed to the lower surface of the baffle, and a limiting rod is slidably installed in the two mounting sleeves, and a connecting sheet metal is rotatably installed between the two limiting rods.

[0013] In at least some embodiments, a continuous unnatural amino acid synthesis reaction apparatus and method of use include the following steps: S1. First, amino acid powder is poured into the reaction box through the feed port, and then the vibration mechanism is used to break up the agglomerated powder in the amino acid, so that the amino acid is in powder form to prevent amino acid agglomeration and assist the subsequent amino acid reaction to be sufficient; S2. The dispersed amino acid powder will be stored on the loading plate. The No. 3 motor can drive the two baffles to expose or seal the delivery hole to achieve quantitative feeding of amino acids. S3. During the process of adjusting the distance between the two baffles, the rotating shaft is driven to rotate, and the stirring plate at the lower end of the rotating shaft is used to stir the amino acid powder in the reaction box, thereby accelerating the amino acid mixing efficiency and assisting the subsequent amino acid fermentation reaction; S4. Start the No. 2 motor to push the amino acids in the reaction box into the fermentation box through the threaded rod. At the same time, the L-shaped limit rod is connected to the sealing partition through the transmission connecting rod, thereby pushing the sealing partition to rotate so that the fermentation box and the interior of the reaction box are connected, thereby achieving quantitative and continuous pushing of amino acids into the fermentation box for fermentation reaction.

[0014] Compared with the prior art, the advantages and positive effects of the present invention are: 1. In the present invention, the side slider and the loading plate are driven to move horizontally by the No. 2 motor. When the loading plate moves following the side slider, the L-shaped limit rod limits it, so that the loading plate rotates around one end of the L-shaped limit rod, and then the loading plate pushes the amino acids in the reaction box into the fermentation box. At the same time, the L-shaped limit rod is connected to the sealing partition through a transmission connecting rod, thereby driving the sealing partition to rotate so that the fermentation box and the interior of the reaction box are connected. The mixed amino acids will be transported to the fermentation box for fermentation reaction.

[0015] 2. In the present invention, during the amino acid addition process, the movable block and the L-shaped connecting block are driven to move back and forth in the main slide rail by motor No. 1, which drives the upper bracket and the lower bracket to move back and forth in an offset direction, and then drives the coarse filter and the fine filter to move back and forth in an offset direction to achieve a vibration effect. The amino acids pass through the coarse filter, the partition and the fine filter in turn, and the agglomerated powder in the amino acids is vibrated and broken up, so that the amino acids are in powder form to prevent amino acid agglomeration, thereby assisting the subsequent amino acid fermentation reaction.

[0016] 3. In the present invention, when the fermentation reaction of amino acids is required, the two baffles can be driven by the No. 3 motor to expose or seal the delivery hole to achieve quantitative control of the amino acids. In the process of adjusting the distance between the two baffles, the rotating shaft is driven to rotate, and the stirring plate at the lower end of the rotating shaft is used to stir the amino acid powder in the reaction box, thereby accelerating the amino acid mixing efficiency and assisting the subsequent amino acid fermentation reaction. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic perspective view of the overall structure of one side of a continuous synthesis reaction device for unnatural amino acids and a method of use proposed by the present invention; Figure 2 This is a schematic perspective view of the other side of the overall structure of a continuous synthesis reaction device for unnatural amino acids and a method of use proposed by the present invention; Figure 3 A schematic perspective view of the cross-sectional structure of a reaction chamber of a continuous unnatural amino acid synthesis reaction apparatus and a method of use proposed in the present invention; Figure 4 A schematic perspective view of the overall structure of the vibration mechanism of the continuous synthesis reaction device and the method of use of non-natural amino acids proposed in the present invention; Figure 5 A schematic perspective view of the vibration mechanism of a continuous unnatural amino acid synthesis reaction device and its use method proposed in the present invention; Figure 6 A schematic three-dimensional diagram of the upper and lower support structures of a continuous synthesis reaction device for unnatural amino acids and a method of use thereof proposed in the present invention; Figure 7 A schematic perspective view of the overall structure of a quantitative mechanism for a continuous synthesis reaction device for unnatural amino acids and a method of use thereof proposed in the present invention; Figure 8 A schematic perspective view of the quantitative mechanism of a continuous synthesis reaction device for unnatural amino acids and a method of use thereof provided by the present invention; Figure 9 This is a schematic three-dimensional diagram of the loading plate structure of a continuous non-natural amino acid synthesis reaction device and its use method proposed by the present invention.

[0018] Legend: 100, box body; 200, humidification equipment; 300, fermentation box; 400, vibration mechanism; 500, quantitative mechanism; 101, fixed bracket; 102, reaction box; 103, support leg; 104, discharge valve; 105, feed port; 106, No. 1 partition; 401, upper bracket; 402, lower bracket; 403, side fixing rod; 404, connecting bracket; 405, main slide rail; 406, movable block; 407, transmission rod; 408, rotating part; 409, L-shaped connecting block; 410, No. 1 motor; 411, connecting rod; 412, coarse filter; 413, No. 2 partition; 414, fine filter; 501 , side slide rail; 502, side slider; 503, loading plate; 504, L-shaped limit rod; 505, conveying hole; 506, mounting groove; 507, No. 2 motor; 508, threaded rod; 509, transmission connecting rod; 510, connecting seat; 511, sealing partition; 512, limit bracket; 513, baffle; 514, connecting block; 515, bidirectional screw; 516, mounting seat; 517, No. 3 motor; 518, gear ring; 519, slip ring; 520, slider; 521, limit rod; 522, stirring plate; 523, driven gear; 524, connecting sheet metal; 525, mounting sleeve; 526, rotating shaft; 527, push rod. DETAILED DESCRIPTION

[0019] In order to more clearly understand the above-mentioned objects, features and advantages of the present invention, the present invention is further described below in conjunction with the accompanying drawings and embodiments. It should be noted that, in the absence of conflict, the embodiments of the present application and the features therein can be combined with each other.

[0020] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0021] Embodiment, according to Figures 1-9 An embodiment of the present invention provides a non-natural amino acid continuous synthesis reaction device and a method for use, comprising a housing 100, wherein a vibration mechanism 400 is installed at the upper portion of the housing 100, and a quantitative mechanism 500 is installed at the lower portion of the housing 100. The housing 100 comprises a reaction box 102, one side of the reaction box 102 is connected to a fermentation box 300, and a humidifier 200 is installed on one side of the upper surface of the fermentation box 300. When the amino acid is delivered to the fermentation box 300 through the quantitative mechanism 500, the humidifier 200 can maintain the humidity in the fermentation box 300, which is conducive to a sufficient fermentation reaction of the amino acid; Figure 3-Figure 4As shown, the reaction box 102 is arranged in a trapezoidal shape, a feed port 105 is arranged above the reaction box 102, a discharge valve 104 is arranged below the reaction box 102, a fixed bracket 101 is fixedly connected to the outside of the reaction box 102, support legs 103 are fixedly connected to the four corners of the lower surface of the fixed bracket 101, and a partition No. 1 106 is fixedly connected to the inner wall of the reaction box 102. Amino acids are poured into the reaction box 102 through the feed port 105, and the discharge valve 104 below the reaction box 102 is manually opened. By switching the discharge valve 104, the amino acids can be exposed from the discharge valve 104 to achieve discharge.

[0022] like Figure 5-Figure 7 As shown, the vibration mechanism 400 includes an upper bracket 401, a lower bracket 402 is further provided below the upper bracket 401, a coarse filter 412 is fixedly connected to the inner side of the upper bracket 401, a second partition 413 is fixedly connected to the upper inner side of the lower bracket 402, and a fine filter 414 is fixedly connected to the lower inner side of the lower bracket 402. The amino acids pass through the coarse filter 412, the second partition 413 and the fine filter 414 in sequence, so as to vibrate and break up the agglomerated powder in the amino acids, make the amino acids powdery, prevent the amino acids from agglomerating, and assist the subsequent fermentation reaction of the amino acids. The outer side of the upper bracket 401 is fixedly connected to a connecting bracket 404, and the connecting bracket 404 is located below the lower bracket 402. A movable block 406 is fixedly connected to the lower surface of the connecting bracket 404. An L-shaped connecting block 409 is fixedly connected to the lower surface of the lower bracket 402 away from the connecting bracket 404. The lower ends of the movable block 406 and the L-shaped connecting block 409 are slidably installed with a main slide rail 405. The two ends of the main slide rail 405 are fixedly connected to a side fixing rod 403. One end of the side fixing rod 403 is fixedly connected to the inner wall of the reaction box 102. One side of the movable block 406 is rotatably installed. Transmission rod 407, one end of the transmission rod 407 is rotatably mounted with a rotating member 408, two rotating members 408 are provided, one of the rotating members 408 is rotatably mounted on an L-shaped connecting block 409, a No. 1 motor 410 is provided below the L-shaped connecting block 409, the No. 1 motor 410 is fixedly connected to the upper surface of the No. 1 partition 106, and the other rotating member 408 is fixedly connected to the output shaft of the No. 1 motor 410. The same end of the two rotating members 408 is rotatably mounted with a connecting rod 411, and starting the No. 1 motor 410 drives one of the rotating members 408 to rotate , and one end of the two rotating parts 408 is connected together by a connecting rod 411, which can drive the two rotating parts 408 to rotate synchronously. When the rotating part 408 on the other side rotates, it is rotated and connected between the movable block 406 and the L-shaped connecting block 409 through the transmission rod 407, thereby adjusting the distance between the two, and then driving the movable block 406 and the L-shaped connecting block 409 to move back and forth in the main slide rail 405, which also drives the upper bracket 401 and the lower bracket 402 to move back and forth in the wrong direction, and then drives the coarse filter 412 and the fine filter 414 to move back and forth in the wrong direction to achieve a vibration effect.

[0023] like Figure 8 As shown, the quantitative mechanism 500 includes two side slide rails 501, each of which is fixed to the inner wall of the reaction box 102, and a side slider 502 is slidably installed in each side slide rail 501, one of the side sliders 502 is engaged with a threaded rod 508, and one end of the threaded rod 508 is fixed to a second motor 507, the second motor 507 is fixed to the inner wall of the reaction box 102, the second motor 507 is located below the first partition 106, and the two side sliders 50 2 is rotatably mounted between the loading plate 503, a delivery hole 505 is provided in the middle of the loading plate 503, a mounting groove 506 is provided on the lower surface of the loading plate 503, an L-shaped limiting rod 504 is rotatably mounted in the middle of both sides of the loading plate 503, one end of the L-shaped limiting rod 504 is rotatably mounted on the inner wall of the reaction box 102, a transmission connecting rod 509 is rotatably mounted below the L-shaped limiting rod 504, and a connecting seat 510 is rotatably mounted at the lower end of the transmission connecting rod 509. One side of the connecting seat 510 is fixed A sealing partition 511 is connected, and the lower end of the sealing partition 511 is rotatably installed at the connection between the reaction box 102 and the fermentation box 300. The second motor 507 drives the threaded rod 508 to rotate. The rotation of the threaded rod 508 can drive the side slider 502 to move horizontally along it. A loading plate 503 is rotatably installed between the side sliders 502. The two sides of the loading plate 503 are connected to the inner wall of the reaction box 102 by L-shaped limiting rods 504, which can limit the loading plate 503. When the loading plate 503 follows the side slider 5 02 moves, the L-shaped limiting rod 504 limits it, so that the loading plate 503 rotates around one end of the L-shaped limiting rod 504, and then the loading plate 503 pushes the amino acids in the reaction box 102 into the fermentation box 300. At the same time, the L-shaped limiting rod 504 is connected to the sealing partition 511 through the transmission connecting rod 509, thereby pushing the sealing partition 511 to rotate so that the fermentation box 300 and the interior of the reaction box 102 are connected, thereby achieving quantitative and continuous pushing of amino acids into the fermentation box 300 for fermentation reaction.

[0024] like Figure 8As shown, baffles 513 are provided on both sides of the mounting groove 506, and connecting blocks 514 are fixed on both sides of each baffle 513. Each connecting block 514 is installed with a limiting bracket 512, and the limiting bracket 512 is fixed to the inner wall of the mounting groove 506. The two connecting blocks 514 are meshed and connected with a bidirectional screw 515 at the same end. The two ends of the bidirectional screw 515 are rotatably installed with a mounting seat 516, and the mounting seat 516 is fixed to the mounting groove 506. One end of the bidirectional screw 515 is fixedly connected to a No. 3 motor 517, and the No. 3 motor 517 is fixed to the mounting seat 516. The No. 3 motor 517 drives the bidirectional screw 515 to rotate. The rotation of the bidirectional screw 515 can drive the connecting block 514 to move synchronously in the opposite direction or inward, thereby driving the baffles 513 to merge and realize the sealing of the conveying hole 505.

[0025] like Figure 9 As shown, two sliders 520 are installed in each of the slip rings 519, and one end of the four sliders 520 is rotatably installed with a rotating shaft 526, the lower ends of the four rotating shafts 526 are fixedly connected to a stirring plate 522, and the upper ends of the four rotating shafts 526 are fixedly connected to a driven gear 523, and the outer side of the driven gear 523 is meshed with a gear ring 518, and the gear ring 518 is fixed to the outer wall of the slip ring 519, and the other ends of the four sliders 520 are rotatably installed with a push rod 527, and one end of the push rod 527 on the same side is rotatably installed with a mounting sleeve 525, and the two mounting sleeves 525 are respectively fixed to the lower surface of the baffle 513, and the two Limit rods 521 are slidably installed in the mounting sleeves 525, and a connecting sheet metal 524 is rotatably installed between the two limit rods 521. During the process of adjusting the distance between the two baffles 513, the mounting sleeve 525 on its lower surface will move horizontally along the limit rods 521. The mounting sleeve 525 drives the slider 520 to move along the slip ring 519 through the push rod 527. During the movement, the driven gear 523 and the gear ring 518 on the surface of the rotating shaft 526 engage with each other, which can drive the rotating shaft 526 to rotate, and stir the amino acid powder in the reaction box 102 through the stirring plate 522 at the lower end of the rotating shaft 526, thereby accelerating the amino acid mixing efficiency and assisting the subsequent amino acid fermentation reaction.

[0026] like Figures 1-9 As shown, a non-natural amino acid continuous synthesis reaction device and a method of use, the specific method of use comprises the following steps: S1. First, amino acid powder is poured into the reaction box 102 through the feed port 105. Then, the vibration mechanism 400 vibrates and breaks up the agglomerated powder in the amino acid, so that the amino acid is in powder form and prevents amino acid agglomeration, thereby assisting the subsequent amino acid reaction. S2. The dispersed amino acid powder is stored on the loading plate 503. The third motor 517 drives the two baffles 513 to expose or seal the delivery hole 505, thereby achieving quantitative feeding of the amino acids. S3. During the process of adjusting the distance between the two baffles 513, the rotating shaft 526 is driven to rotate, and the stirring plate 522 at the lower end of the rotating shaft 526 is used to stir the amino acid powder in the reaction box 102, thereby accelerating the amino acid mixing efficiency and assisting the subsequent amino acid fermentation reaction; S4. Start the second motor 507 to push the amino acids in the reaction box 102 into the fermentation box 300 through the threaded rod 508. At the same time, the L-shaped limiting rod 504 is connected to the sealing partition 511 through the transmission connecting rod 509, thereby pushing the sealing partition 511 to rotate so that the fermentation box 300 and the interior of the reaction box 102 are connected, thereby achieving quantitative and continuous pushing of amino acids into the fermentation box 300 for fermentation reaction.

[0027] The working principle of the present invention is as follows: first, the amino acid powder is poured into the reaction box 102 through the feed port 105. During the process of adding amino acids, the No. 1 motor 410 is started to drive one of the rotating parts 408 to rotate, and one end of the two rotating parts 408 is connected together by a connecting rod 411, which can drive the two rotating parts 408 to rotate synchronously. When the rotating part 408 on the other side rotates, it is rotated and connected between the movable block 406 and the L-shaped connecting block 409 through the transmission rod 407, thereby adjusting the distance between the two, and then driving the movable block 406 and the L-shaped connecting block 409 to move back and forth in the main slide rail 405, which also drives the upper bracket 401 and the lower bracket 402 to move back and forth in the wrong direction, and then drives the coarse filter 412 and the fine filter 414 to move back and forth. The compound staggered motion achieves the effect of vibration. The amino acids pass through the coarse filter 412, the second partition 413 and the fine filter 414 in turn, so as to achieve the vibration and break up of the agglomerated powder in the amino acids, making the amino acids powdery to prevent amino acids from agglomerating, and assisting the subsequent amino acids in fermentation reaction. The third motor 517 drives the bidirectional screw 515 to rotate. The rotation of the bidirectional screw 515 can drive the connecting block 514 to move synchronously in the opposite direction, thereby driving the baffle 513 to move the two sides of the conveying hole 505 to expose the conveying hole 505, and then the amino acids will fall into the reaction box 102. When the amino acids need to be fermented, the third motor 517 can be started again to drive the two baffles 513 to seal the conveying hole 505, and a quantitative amount of amino acids can be obtained. The acid will be stored at the bottom of the reaction box 102. During the process of adjusting the distance between the two baffles 513, the mounting sleeve 525 on its lower surface will move horizontally along the limiting rod 521. The mounting sleeve 525 drives the slider 520 to move along the slip ring 519 through the push rod 527. During the movement, the driven gear 523 on the surface of the rotating shaft 526 and the gear ring 518 are engaged, which can drive the rotating shaft 526 to rotate, and the stirring plate 522 at the lower end of the rotating shaft 526 is used to stir the amino acid powder in the reaction box 102, thereby accelerating the amino acid mixing efficiency and assisting the subsequent amino acid fermentation reaction. At this time, the second motor 507 is started to drive the threaded rod 508 to rotate. The rotation of the threaded rod 508 can drive the side slider 502 to move horizontally along it. A loading plate 503 is rotatably installed between the side sliders 502. Both sides of the loading plate 503 are connected to the inner wall of the reaction box 102 by L-shaped limiting rods 504, which can limit the loading plate 503. When the loading plate 503 moves with the side sliders 502, the L-shaped limiting rods 504 limit it, so that the loading plate 503 rotates with one end of the L-shaped limiting rod 504 as the center, and then the loading plate 503 pushes the amino acids in the reaction box 102 into the fermentation box 300. At the same time, the L-shaped limiting rod 504 is connected to the sealing partition 511 through the transmission connecting rod 509, thereby pushing the sealing partition 511 to rotate so that the fermentation box 300 and the interior of the reaction box 102 are connected, and the mixed amino acids will be transported to the fermentation box 300 for fermentation reaction.

[0028] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention in any other form. Any person skilled in the art may use the technical contents disclosed above to change or modify them into equivalent embodiments with equivalent changes for application in other fields. However, any simple modification, equivalent change and modification of the above embodiments made in accordance with the technical essence of the present invention without departing from the technical solution of the present invention shall still fall within the scope of protection of the technical solution of the present invention.

Claims

1. A non-natural amino acid continuous synthesis reaction device, comprising a box structure (100), characterized in that: A vibration mechanism (400) is installed on the upper portion of the box mechanism (100), a quantitative mechanism (500) is installed on the lower portion of the box mechanism (100), the box mechanism (100) comprises a reaction box (102), one side of the reaction box (102) is connected to a fermentation box (300), and a humidifying device (200) is installed on one side of the upper surface of the fermentation box (300); The reaction box (102) is arranged in a trapezoidal shape, a feed port (105) is arranged above the reaction box (102), a discharge valve (104) is arranged below the reaction box (102), a fixed bracket (101) is fixedly connected to the outside of the reaction box (102), support legs (103) are fixedly connected at the four corners of the lower surface of the fixed bracket (101), and a partition plate (106) is fixedly connected to the inner wall of the reaction box (102).

2. The non-natural amino acid continuous synthesis reaction device according to claim 1, wherein: The vibration mechanism (400) comprises an upper bracket (401), a lower bracket (402) is further provided below the upper bracket (401), a coarse filter (412) is fixedly connected to the inner side of the upper bracket (401), a second partition (413) is fixedly connected to the upper inner side of the lower bracket (402), and a fine filter (414) is fixedly connected to the lower inner side of the lower bracket (402).

3. The non-natural amino acid continuous synthesis reaction device according to claim 2, wherein: The outer side of the upper bracket (401) is fixedly connected to a connecting bracket (404), and the connecting bracket (404) is located below the lower bracket (402). The lower surface of the connecting bracket (404) is fixedly connected to a movable block (406). The lower surface of the lower bracket (402) is fixedly connected to an L-shaped connecting block (409) on the side away from the connecting bracket (404). The lower ends of the movable block (406) and the L-shaped connecting block (409) are slidably mounted with a main slide rail (405). Both ends of the main slide rail (405) are fixedly connected to a side fixing rod (403), and one end of the side fixing rod (403) is fixedly connected to the inner wall of the reaction box (102).

4. The unnatural amino acid continuous synthesis reaction device according to claim 3, wherein: A transmission rod (407) is rotatably mounted on one side of the movable block (406), and a rotating member (408) is rotatably mounted on one end of the transmission rod (407). Two rotating members (408) are provided, one of which is rotatably mounted on an L-shaped connecting block (409). A No. 1 motor (410) is provided below the L-shaped connecting block (409), and the No. 1 motor (410) is fixedly connected to the upper surface of the No. 1 partition (106). The other rotating member (408) is fixedly connected to the output shaft of the No. 1 motor (410). A connecting rod (411) is rotatably mounted on the same end of the two rotating members (408).

5. The non-natural amino acid continuous synthesis reaction device according to claim 1, characterized in that: The quantitative mechanism (500) includes two side slide rails (501), each of the side slide rails (501) is fixed to the inner wall of the reaction box (102), and a side slider (502) is slidably installed in each side slide rail (501), one of the side sliders (502) is engaged with a threaded rod (508), one end of the threaded rod (508) is fixed to a second motor (507), the second motor (507) is fixed to the inner wall of the reaction box (102), and the second motor (507) is located below the first partition (106).

6. The unnatural amino acid continuous synthesis reaction device according to claim 5, characterized in that: A loading plate (503) is rotatably mounted between the two side sliders (502), a conveying hole (505) is provided in the middle of the loading plate (503), and a mounting groove (506) is provided on the lower surface of the loading plate (503). L-shaped limiting rods (504) are rotatably mounted in the middle of both sides of the loading plate (503), one end of the L-shaped limiting rod (504) is rotatably mounted on the inner wall of the reaction box (102), a transmission connecting rod (509) is rotatably mounted below the L-shaped limiting rod (504), a connecting seat (510) is rotatably mounted at the lower end of the transmission connecting rod (509), a sealing partition (511) is fixedly connected to one side of the connecting seat (510), and the lower end of the sealing partition (511) is rotatably mounted at the connection between the reaction box (102) and the fermentation box (300).

7. The unnatural amino acid continuous synthesis reaction device according to claim 6, characterized in that: Baffles (513) are provided on both sides of the installation groove (506), and connecting blocks (514) are fixed on both sides of each baffle (513). A limiting bracket (512) is installed on each connecting block (514), and the limiting bracket (512) is fixed to the inner wall of the installation groove (506). The same end of the two connecting blocks (514) is meshedly connected with a bidirectional screw (515), and both ends of the bidirectional screw (515) are rotatably installed with a mounting seat (516), and the mounting seat (516) is fixed to the installation groove (506). One end of the bidirectional screw (515) is fixed with a No. 3 motor (517), and the No. 3 motor (517) is fixed to the mounting seat (516). The lower surfaces of the two baffles (513) are fixed with a slip ring (519).

8. The unnatural amino acid continuous synthesis reaction device according to claim 7, characterized in that: Two sliders (520) are installed in each of the slip rings (519), and one end of each of the four sliders (520) is rotatably installed with a rotating shaft (526), the lower ends of the four rotating shafts (526) are fixedly connected to a stirring plate (522), and the upper ends of the four rotating shafts (526) are fixedly connected to a driven gear (523), the outer side of the driven gear (523) is meshed with a gear ring (518), and the gear ring (518) is fixed to the outer wall of the slip ring (519), and the other ends of the four sliders (520) are rotatably installed with a push rod (527), and one end of the push rod (527) on the same side is rotatably installed with a mounting sleeve (525), and the two mounting sleeves (525) are respectively fixed to the lower surface of the baffle (513), and a limiting rod (521) is slidably installed in the two mounting sleeves (525), and a connecting sheet metal (524) is rotatably installed between the two limiting rods (521).

9. A method for using a non-natural amino acid continuous synthesis reaction device, characterized in that: The method of using the non-natural amino acid continuous synthesis reaction device according to any one of claims 1 to 8 comprises the following steps: S1. First, amino acid powder is poured into the reaction box (102) through the feed port (105), and then the vibration mechanism (400) vibrates and breaks up the agglomerated powder in the amino acid, so that the amino acid is in powder form, the amino acid is prevented from agglomerating, and the subsequent amino acid reaction is fully assisted; S2. The dispersed amino acid powder is stored on the loading plate (503). The third motor (517) drives the two baffles (513) to expose or seal the delivery hole (505), thereby achieving quantitative delivery of amino acids. S3. During the process of adjusting the distance between the two baffles (513), the rotating shaft (526) is driven to rotate, and the stirring plate (522) at the lower end of the rotating shaft (526) is used to stir the amino acid powder in the reaction box (102), thereby accelerating the amino acid mixing efficiency and assisting the subsequent amino acid fermentation reaction; S4. Start the second motor (507) to push the amino acids in the reaction box (102) into the fermentation box (300) through the threaded rod (508). At the same time, the L-shaped limiting rod (504) is connected to the sealing partition (511) through the transmission connecting rod (509), thereby pushing the sealing partition (511) to rotate so that the fermentation box (300) and the interior of the reaction box (102) are connected, thereby achieving quantitative and continuous pushing of amino acids into the fermentation box (300) for fermentation reaction.

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