Mouse tail pressing and auxiliary intravenous injection device
By designing mouse tail compression and auxiliary intravenous injection devices, the problems of unstable and discomfort in tail fixation in traditional devices are solved, and a stable and comfortable intravenous injection effect is achieved.
Patent Information
- Application Number
- CN202510781925.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-12
- Publication Date
- 2025-08-15
AI Technical Summary
Traditional mouse tail fixators are difficult to adjust the squeeze pressure, causing tail shaking, affecting the stability and efficiency of intravenous injection, and the compression position is unadjustable, resulting in discomfort and stress response in mice, making it difficult to clearly show the venous position.
A mouse tail compression and auxiliary intravenous injection device is designed, including a support panel, a U-shaped plate, a press block, a guide mechanism, a vertical lifting rod, an axial adjustment locking mechanism and a yellow light lighting system. By adjusting the lifting and locking mechanism of the press block, stable fixation of the tail and clear vein imaging is achieved.
The stable compression and comfort of the tail are achieved, the efficiency and accuracy of intravenous injection are improved, the discomfort reactions in mice are reduced, and the operation difficulty is simplified.
Smart Images
Figure CN120477996A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of medical devices, and in particular to a mouse tail pressing and auxiliary intravenous injection device. Background Art
[0002] Experimental tail clamping mechanisms are widely used in many scientific research sites and are suitable for medical science research institutions of all sizes, biological research centers, animal quarantine centers, and laboratories of colleges and universities.
[0003] Currently, the use of experimental mice to conduct experimental research in exploring gene functions, causes and pathogenesis is very common and has broad application prospects. Mouse tail vein injection is simple and easy to perform injections and blood collection operations; in addition, the tail vein is located superficially and fixed, which facilitates stable and accurate injections. Intravenous injection of drugs has rapid absorption and the highest utilization rate, with significant effects, and is suitable for experiments that require precise control of drug dosage and speed. Tail vein injection is widely used and is suitable for a variety of experiments, including pharmacological research and pharmacokinetic research. It can ensure rapid distribution of drugs and provide support for subsequent immune response research. Because mice are small in size, sensitive to external stimuli, timid and easily startled, and their tail veins are relatively thin, it is crucial to optimize the fixation method and device for the mouse and its tail during tail vein injection.
[0004] Traditional mouse and tail holders are cylindrical devices with a retractable opening on one end and a ventilated opening on the other. For tail vein injection, the mouse is placed inside the holder, one end is then sealed, and the opening is left open to expose the mouse's tail for easy insertion. This is especially important for tail vein injections, as the mouse and its tail must be secured to maintain stability and facilitate the procedure.
[0005] When squeezing is used to fix the mouse tail, the squeezing force cannot be adjusted, making it difficult to prevent the mouse tail from shaking and inconvenient for tail vein injection; when the squeezing force is too large, the experimental mouse will feel less comfortable and prone to stress reactions; the squeezing position of the mouse tail cannot be adjusted, making it difficult to meet the needs of tail vein injection; it is difficult to clearly show the position and distribution of the mouse tail vein, resulting in poor efficiency of tail vein injection and increasing the difficulty of operation for the experimenter. Summary of the Invention
[0006] The object of the present invention is to provide a mouse tail clamping and auxiliary intravenous injection device, which solves the problems in the prior art that when squeezing and fixing the mouse tail, the squeezing force cannot be adjusted, making it difficult to prevent the mouse tail from shaking and inconvenient for tail vein injection; when the squeezing force is too large, the experimental mouse is less comfortable and is prone to stress reactions; the squeezing position of the mouse tail cannot be adjusted, making it difficult to meet the needs of tail vein injection; it is difficult to clearly show the position and distribution of the mouse tail vein, resulting in poor tail vein injection efficiency and increased difficulty in operation for the experimenter.
[0007] To achieve the above-mentioned objectives, the present invention provides a mouse tail clamping and auxiliary intravenous injection device, including a support panel, a U-shaped plate, a pressure block, two guide mechanisms, a vertical lifting rod, a tail placement plate, an axial adjustment locking mechanism and a yellow light illumination system, the pressure block including an inverted V-shaped clamping plate and a fixed block, the fixed block has sliding grooves on both sides, the middle of the fixed block has a thread, the tail placement plate has a V-shaped groove, the axial adjustment locking mechanism is arranged at the upper end of the support panel, the tail placement plate is arranged at the upper end of the axial adjustment locking mechanism, the U-shaped plate is fixedly arranged at the upper end of the tail placement plate, the two guide mechanisms are symmetrically arranged on the U-shaped plate, the pressure block is located between the two guide mechanisms, the two guide mechanisms are slidably adapted to the corresponding sliding grooves, the vertical lifting rod passes through the U-shaped plate and is adapted to the thread.
[0008] Among them, the mouse tail clamping and auxiliary intravenous injection device also includes an L-shaped tail blocking plate, a first locking bolt and a first nut, the L-shaped tail blocking plate has a U-shaped opening, the L-shaped tail blocking plate is arranged at the upper end of the support panel, the first locking bolt passes through the support panel and the L-shaped tail blocking plate, the first nut is arranged on the first locking bolt, and the first nut is against the L-shaped tail blocking plate.
[0009] Wherein, the lower end of the inverted V-shaped clamping plate is provided with a rubber pad.
[0010] In which, the axial adjustment locking mechanism includes two L-shaped plates, two second locking bolts, and two second nuts. The support panel has two strip-shaped slots. The two L-shaped plates are respectively placed on the upper ends of the support panel. The two second locking bolts pass through the corresponding strip-shaped slots respectively. The two second nuts are respectively adapted to the corresponding second locking bolts, and the two second nuts are abutted against the corresponding L-shaped plates. The tail placement plate is fixedly arranged on the upper ends of the two L-shaped plates, and the L-shaped tail blocking plate is located between the two L-shaped plates.
[0011] Wherein, the yellow light lighting system includes a bulb and a generator switch, the bulb is arranged at the lower end of the V-shaped groove, and the generator switch is arranged at the lower end of the V-shaped groove.
[0012] The present invention provides a mouse tail clamping and auxiliary intravenous injection device. By rotating the vertical lifting rod, the lifting and rotating rod cooperates with the thread, and with the cooperation of the two guide mechanisms and the corresponding slide grooves, the pressing block is limited so that the pressing block only rises or falls but does not rotate, thereby facilitating the clamping or loosening of the mouse tail, preventing the mouse tail from shaking, facilitating subsequent experiments, and not causing discomfort to the mouse. BRIEF DESCRIPTION OF THE DRAWINGS
[0013] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art.
[0014] Figure 1 It is a schematic structural diagram of the entire invention.
[0015] Figure 2 It is a side view of the entire present invention.
[0016] Figure 3 It is a partial structural schematic diagram of the present invention.
[0017] Figure 4 It is a front view of the compact of the present invention.
[0018] Figure 5 It is a top view of the compact of the present invention.
[0019] 1-Support panel, 2-U-shaped plate, 3-Pressure block, 4-Guide mechanism, 5-Vertical lifting rod, 6-Tail placement plate, 7-Inverted V-shaped clamping plate, 8-Fixed block, 9-Slide groove, 10-Thread, 11-V-shaped groove, 12-L-shaped tail blocking plate, 13-First locking bolt, 14-First nut, 15-U-shaped opening, 16-Rubber pad, 17-L-shaped plate, 18-Second locking bolt, 19-Second nut, 20-Bar slide groove, 21-Light bulb, 22-Generator switch. DETAILED DESCRIPTION
[0020] The embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, but should not be understood as limiting the present invention.
[0021] See also Figures 1 to 5 ,in, Figure 1 It is a schematic diagram of the overall structure of the present invention, Figure 2 is a side view of the entirety of the present invention, Figure 3 It is a partial structural diagram of the present invention, Figure 4 It is a front view of the pressing block 3 of the present invention, Figure 5It is a top view of the compact 3 of the present invention.
[0022] The present invention provides a mouse tail clamping and auxiliary intravenous injection device, comprising a support panel 1, a U-shaped plate 2, a pressing block 3, two guide mechanisms 4, a vertical lifting rod 5, a tail placement plate 6, an axial adjustment locking mechanism and a yellow light illumination system, wherein the pressing block 3 comprises an inverted V-shaped clamping plate 7 and a fixed block 8, the fixed block 8 has slide grooves 9 on both sides, the fixed block 8 has a thread 10 in the middle, the tail placement plate 6 has a V-shaped groove 11, the axial adjustment locking mechanism is arranged at the upper end of the support panel 1, the tail placement plate 6 is arranged at the upper end of the axial adjustment locking mechanism, the U-shaped plate 2 is fixedly arranged at the upper end of the tail placement plate 6, the two guide mechanisms 4 are symmetrically arranged on the U-shaped plate 2, the pressing block 3 is located between the two guide mechanisms 4, the two guide mechanisms 4 are slidably adapted to the corresponding slide grooves 9, the vertical lifting rod 5 passes through the U-shaped plate 2 and is adapted to the thread 10.
[0023] In this embodiment, the vertical lifting rod 5 is rotated to cooperate with the lifting rotating rod and the thread 10, and with the cooperation of the two guide mechanisms 4 and the corresponding slide grooves 9, the pressing block 3 is limited so that the pressing block 3 only rises or falls but does not rotate, which is beneficial to the tightening or loosening of the mouse tail, preventing the mouse tail from shaking, facilitating subsequent experiments, and not making the mouse uncomfortable.
[0024] Furthermore, the mouse tail clamping and auxiliary intravenous injection device also includes an L-shaped tail blocking plate 12, a first locking bolt 13 and a first nut 14, the L-shaped tail blocking plate 12 has a U-shaped opening 15, the L-shaped tail blocking plate 12 is arranged at the upper end of the support panel 1, the first locking bolt 13 passes through the support panel 1 and the L-shaped tail blocking plate 12, the first nut 14 is arranged on the first locking bolt 13, and the first nut 14 is against the L-shaped tail blocking plate 12.
[0025] In this embodiment, when in use, the device is placed at the rear end of the cylindrical fixture, and the tail of the mouse is supported by the L-shaped tail blocking plate 12 to prevent the mouse from moving in the cylindrical fixture. After the mouse is fixed, the tail of the mouse can be pulled out of the U-shaped opening 15 and then placed on the tail placement plate 6 to facilitate intravenous injection. The L-shaped tail blocking plate 12 has an arc-shaped protrusion, which can better fix the mouse, and the L-shaped tail blocking plate 12 is fixed to the support panel 1 through the cooperation of the first locking bolt 13 and the first nut 14.
[0026] Furthermore, a rubber pad 16 is provided at the lower end of the inverted V-shaped clamping plate 7 .
[0027] In this embodiment, the provision of the rubber pad 16 prevents the inverted V-shaped clamping plate 7 from directly and rigidly contacting the mouse's tail, thereby preventing the mouse's tail from being squeezed and damaged.
[0028] Furthermore, the axial adjustment locking mechanism includes two L-shaped plates 17, two second locking bolts 18, and two second nuts 19. The support panel 1 has two strip-shaped slots 20. The two L-shaped plates 17 are respectively placed on the upper end of the support panel 1. The two second locking bolts 18 pass through the corresponding strip-shaped slots 20 respectively. The two second nuts 19 are respectively adapted to the corresponding second locking bolts 18, and the two second nuts 19 are abutted against the corresponding L-shaped plates 17. The tail placement plate 6 is fixedly arranged on the upper ends of the two L-shaped plates 17, and the L-shaped tail blocking plate 12 is located between the two L-shaped plates 17.
[0029] In this embodiment, by screwing the second nut 19 and the second locking bolt 18, the limiting fixation of the two L-shaped plates 17 can be cancelled, and axial adjustment can be performed. By changing the pressing position of the mouse tail along the axial adjustment, it is convenient to pull out the mouse tail and select the required vein position for injection.
[0030] Furthermore, the yellow light illumination system includes a bulb 21 and a generator switch 22 . The bulb 21 is disposed at the lower end of the V-shaped groove 11 , and the generator switch 22 is disposed at the lower end of the V-shaped groove 11 .
[0031] In this embodiment, after the mouse tail is fixed on the tail placement plate 6, the light bulb 21 is turned on by the generator switch 22, thereby illuminating the position where intravenous injection is required, so that the tail vein is clearly imaged, making it convenient to observe the clear vein for injection and adjust the injection position as needed. The display of the tail vein is adjusted as needed by the switch.
[0032] The beneficial effects of the present invention are as follows: the clamping position and clamping force of the device are well adjustable, which effectively ensures the stability and comfort of mice and avoids discomfort and stress reactions of mice that may be caused by traditional devices; the design of the L-shaped tail blocking plate 12 and the U-shaped opening 15 of the device ensures that the mouse tail can be easily taken out of the barrel and placed into the clamping mechanism, which improves the operating efficiency; in addition, the screw-type lifting clamping and its guide mechanism 4 are used to quickly clamp and loosen the mouse tail; the clamping position can also be quickly adjusted as needed through the axial locking mechanism, which is convenient for the operator to perform convenient injection operations; it is convenient to complete the adjustment, fixing, and loosening actions according to needs, so that the clamping of the mouse tail is more appropriate and the loosening and removal is more convenient; the designed lighting lamp makes the tail vein clearly visible, which is convenient for seeing the tail vein and speeding up the operation process; the fixing device is integrated and portable, and each component can be quickly assembled and disassembled, which is also conducive to cleaning dirt.
[0033] In summary, the present invention has a reasonable structural design, convenient adjustment, reliable compression, good comfort, easy use, and can complete the tail vein injection operation in a short time; it causes little damage to mice during compression, and the degree of compression can be adjusted as needed; the device adopts an integrated design and is portable, making it a good helper for scientific researchers; it adopts an open structure, is easy to clean, and has good practicality and adaptability.
[0034] When using the mouse tail compression and auxiliary intravenous injection device of the present invention, the mouse tail is first removed from the barrel through the U-shaped opening 15 on the L-shaped tail blocking plate 12. The axial position of the axial adjustment locking mechanism is determined according to the appropriate tail intravenous injection position, and locked using two second locking bolts 18 and two second nuts 19. Then, the vertical lifting rod 5 rotates and, under the guidance of the guide mechanism 4, drives the pressing block 3 to descend but not rotate, thereby comfortably compressing the mouse tail. Secondly, after soaking the mouse's tail in hot water, turn on the light to clearly show the distribution of the mouse's tail veins and prepare for injection; then, place the mouse in a lateral position, and under the illumination of yellow light, the tail vein will be clearly presented; generally, find the lateral tail vein first, and if the lateral tail vein is not clear, then find the dorsal tail vein; after finding the puncture point, use alcohol to disinfect the injection site, lock the axial position of the clamping mechanism, and press down the clamp to further expand the blood vessels; then, pinch the tip of the mouse's tail with one hand to prevent it from swinging due to the mouse's struggle during the injection process; hold the syringe with the other hand so that the needle tip is facing upwards, and the entire The needle is placed against the tail, along the direction of the tail vein, and slowly inserted parallel to it. Generally, the tail vein can be punctured when the needle is about 1-1.5mm deep. After successful puncture, a push injection can be performed. If the injection volume is less than 100μL, it can be injected quickly to prevent the mouse from struggling and getting rid of the needle. If the injection volume is large, the flow rate must be controlled and not too fast. After the push injection is completed, it is necessary to wait a few seconds before withdrawing the needle. Withdraw the needle quickly and then immediately use a hemostatic clamp or other method to stop bleeding. After the injection is completed, turn off the lights, loosen the tail clamping mechanism, remove the two opening locking mechanisms and the axial clamping screw, remove the mouse, and complete the entire mouse intravenous injection. After the injection is completed, turn off the lights, loosen the tail clamping mechanism, and then complete the entire mouse tail intravenous injection.
[0035] The above disclosure is merely one or more preferred embodiments of the present application and is not intended to limit the scope of the present application. A person skilled in the art will understand that all or part of the processes of the above embodiments and equivalent changes made in accordance with the claims of the present application are still within the scope of the present application.
Claims
1. A mouse tail clamping and auxiliary intravenous injection device, characterized in that: It includes a support panel, a U-shaped plate, a pressure block, two guide mechanisms, a vertical lifting rod, a tail placement plate, an axial adjustment locking mechanism and a yellow light lighting system; The pressing block includes an inverted V-shaped clamping plate and a fixed block, the fixed block has sliding grooves on both sides, the middle of the fixed block has a thread, the tail placement plate has a V-shaped groove, the axial adjustment locking mechanism is arranged at the upper end of the support panel, the tail placement plate is arranged at the upper end of the axial adjustment locking mechanism, the U-shaped plate is fixedly arranged at the upper end of the tail placement plate, the two guide mechanisms are symmetrically arranged on the U-shaped plate, the pressing block is located between the two guide mechanisms, the two guide mechanisms are slidably adapted to the corresponding sliding grooves, the vertical lifting rod passes through the U-shaped plate and is adapted to the thread.
2. The mouse tail compression and auxiliary intravenous injection device according to claim 1, characterized in that: The mouse tail clamping and auxiliary intravenous injection device also includes an L-shaped tail blocking plate, a first locking bolt and a first nut. The L-shaped tail blocking plate has a U-shaped opening. The L-shaped tail blocking plate is arranged at the upper end of the support panel. The first locking bolt passes through the support panel and the L-shaped tail blocking plate. The first nut is arranged on the first locking bolt, and the first nut is abutted against the L-shaped tail blocking plate.
3. The mouse tail compression and auxiliary intravenous injection device according to claim 2, characterized in that: The lower end of the inverted V-shaped clamping plate is provided with a rubber pad.
4. The mouse tail compression and auxiliary intravenous injection device according to claim 3, characterized in that: The axial adjustment locking mechanism includes two L-shaped plates, two second locking bolts, and two second nuts. The support panel has two strip-shaped slots. The two L-shaped plates are respectively placed on the upper ends of the support panel. The two second locking bolts pass through the corresponding strip-shaped slots respectively. The two second nuts are respectively adapted to the corresponding second locking bolts, and the two second nuts are abutted against the corresponding L-shaped plates. The tail placement plate is fixedly arranged on the upper ends of the two L-shaped plates, and the L-shaped tail blocking plate is located between the two L-shaped plates.
5. The mouse tail compression and auxiliary intravenous injection device according to claim 4, characterized in that: The yellow light illumination system includes a bulb and a generator switch. The bulb is arranged at the lower end of the V-shaped groove, and the generator switch is arranged at the lower end of the V-shaped groove.