Light guide gel and preparation method thereof

Abstract

The invention provides a light guide gel and a preparation method thereof, the light guide gel comprises a light guide agent and nano zinc oxide, and the light guide agent comprises polydimethylsiloxane. Due to the addition of the polydimethylsiloxane, due to the characteristics of high transparency and low scattering of the polydimethylsiloxane, the interface reflection of the light guide gel is reduced, the light guide property is improved, and the photon treatment efficiency is further improved; due to the compounding of nano-zinc oxide and the good heat-conducting property of the nano-zinc oxide, the heat damage of the light guide gel to local skin due to efficient light guide of polydimethylsiloxane can be reduced; the bisabolol can regulate the microenvironment of the skin, and further protect the skin from high-temperature injury and improve the comfort level by matching with the moisturizing effect of the moisturizer while relieving and resisting inflammation.

Description

Technical Field

[0001] The present invention relates to the technical field of medical gels, in particular to a light-guiding gel and a preparation method thereof. Background Art

[0002] Light-guiding gel often plays a key role in photoelectric medical aesthetic treatment. It is a polymer gel product, usually composed of carbomer, glycerin and water. It is used in conjunction with phototherapy equipment and applied to the surface of the skin that needs phototherapy. It can evenly distribute the light source in the treatment area, and play a role in heat insulation and light guidance, avoiding skin burns caused by excessive temperature during laser medical aesthetic treatment, and can effectively improve the treatment effect and ensure safety during the treatment process.

[0003] Currently available light-guiding gels typically consist of carbomer, glycerin, and water, with some containing preservatives, viscosity adjusters, and odor-modifying ingredients such as ethylparaben, triethanolamine, and fragrance. Existing light-guiding gels are prone to drying out, leading to localized overheating during laser treatment and causing skin damage. Some models can even cause allergic reactions. The light-guiding gels in this invention improve their light-guiding properties and disperse localized heat from the skin.

[0004] In view of this, it is necessary to invent a light-guiding gel that combines comfort and safety while ensuring light-guiding performance. Summary of the Invention

[0005] In view of this, the present invention proposes a light-guiding gel and a preparation method thereof. The light-guiding gel is safe, comfortable and has good performance. It has good light-guiding properties and comfort, can efficiently guide light and can disperse local high temperatures of the skin.

[0006] The technical solution of the present invention is achieved as follows:

[0007] In a first aspect, the present invention provides a light-conducting gel comprising a light-conducting agent and nano zinc oxide, wherein the light-conducting agent comprises polydimethylsiloxane.

[0008] Polydimethylsiloxane has high light transmittance and can improve the transmittance of light-guiding gel, but at the same time it will also cause thermal damage due to excessive local light temperature on the skin. Nano zinc oxide has high thermal conductivity and can efficiently conduct heat and disperse local high temperature on the skin.

[0009] On the basis of the above technical solution, further, the mass fraction of the polydimethylsiloxane is 1 to 3 wt %, and the mass fraction of the nano zinc oxide is 0.01 to 0.03 wt %.

[0010] On the basis of the above technical solution, the invention further comprises a thickener, a moisturizer, a preservative, a skin conditioner, a pH regulator, ethanol and water.

[0011] On the basis of the above technical solution, further, the skin conditioning agent is bisabolol, with a mass fraction of 0.3 to 0.8 wt%.

[0012] On the basis of the above technical solution, further, the thickener includes one or more of carbomer, xanthan gum, carboxymethyl cellulose, and hydroxyethyl cellulose, and the mass fraction of the thickener is 0.3-0.5 wt%.

[0013] On the basis of the above technical solution, further, the moisturizing agent includes one or more of glycerol, propylene glycol, and 1,4-butylene glycol, and the mass fraction of the moisturizing agent is 4 to 10 wt%.

[0014] On the basis of the above technical solution, further, the preservative includes one or more of methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate and sodium benzoate, and the mass fraction of the preservative is 0.05 to 0.2 wt%.

[0015] On the basis of the above technical solution, further, the pH regulator includes sodium hydroxide and / or triethanolamine, and the mass fraction of the pH regulator is 0.25 to 0.65 wt%.

[0016] In a second aspect, the present invention provides a method for preparing the above-mentioned light-guiding gel, comprising the following steps: S1, sprinkling a thickener onto a water surface, allowing it to stand for natural swelling, and then heating and mixing to obtain a solution A;

[0017] S2, heating and mixing the moisturizing agent, light guiding agent, preservative and nano zinc oxide to obtain solution B;

[0018] S3. Add ethanol and skin conditioner and mix well to obtain solution C;

[0019] S4. Add the solution B and solution C to the solution A, mix well, and dropwise add a pH adjuster to adjust the pH to obtain the light-guiding gel.

[0020] On the basis of the above technical solution, preferably, the standing time is 16 to 24 hours.

[0021] Based on the above technical solution, preferably, the heating temperature in step S1 is 60-80°C.

[0022] Based on the above technical solution, preferably, the heating temperature in step S2 is less than 40°C.

[0023] On the basis of the above technical solution, preferably, the mixing method in step S4 is stirring, and the stirring time is 5 to 10 minutes.

[0024] On the basis of the above technical solution, preferably, the pH is 5.5 to 7.5.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] (1) The addition of polydimethylsiloxane, due to its high transparency and low scattering properties, reduces the interfacial reflection of the light-guiding gel and improves the light-guiding property; the compounding of nano-zinc oxide, due to its good thermal conductivity, can reduce the thermal damage to the local skin caused by the high efficiency of polydimethylsiloxane light-guiding; bisabolol can regulate the microenvironment of the skin, while soothing and anti-inflammatory, combined with the moisturizing effect of the moisturizer, further protect the skin from high temperature damage and improve comfort. DETAILED DESCRIPTION

[0027] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0028] Polydimethylsiloxane was purchased from Kangdaoning with the product number of PMX-200350cSt and a molecular weight of approximately 10,000 g / mol.

[0029] Nano zinc oxide was purchased from Sinopharm Reagent with the product number XW01131413233.

[0030] Carbomer was purchased from Sinopharm Reagent with the product number XW01900720908.

[0031] Glycerol was purchased from Sinopharm Reagent with the product number 10010618.

[0032] Propylene glycol was purchased from Sinopharm Reagent with the product number 30157018.

[0033] Ethyl p-hydroxybenzoate was purchased from Sinopharm Reagent with the product number 30086926.

[0034] Ethanol was purchased from Sinopharm Reagent with the product number 10009292.

[0035] Bisabolol was purchased from Sinopharm Reagent with the product number XW05156951.

[0036] Triethanolamine was purchased from Sinopharm Reagent with the product number 10023118.

[0037] Example 1

[0038] This embodiment provides a method for preparing a light-guiding gel, comprising the following steps:

[0039] S1. Add 89.23 mL of purified water to a reaction vessel, weigh 0.35 g of carbomer and sprinkle evenly on the liquid surface. Let it stand for 20 h to allow it to swell naturally. Then heat to 60°C and stir to mix evenly.

[0040] S2. Weigh 3 g of glycerol and 3 g of propylene glycol, add 2 g of polydimethylsiloxane, 0.1 g of ethyl paraben, and 0.02 g of nano zinc oxide, heat at 35°C with stirring, and then ultrasonicate to mix evenly.

[0041] S3. Weigh 1.5 g of ethanol, add 0.5 g of bisabolol, and stir evenly.

[0042] S4. Pour the mixed solution obtained in steps S3 and S2 into step S1, stir for 5 minutes to mix evenly, and then dropwise add 0.3 g of triethanolamine to adjust the pH to 7.0 to obtain the light-guiding gel.

[0043] Example 2

[0044] This embodiment provides a method for preparing a light-guiding gel. Compared with Example 1, the difference is that the mass of polydimethylsiloxane is 1 g, the mass of nano-zinc oxide is 0.03 g, and the volume of purified water is 90.22 mL.

[0045] Example 3

[0046] This embodiment provides a method for preparing a light-guiding gel. Compared with Example 1, the difference is that the mass of polydimethylsiloxane is 3 g, the mass of nano-zinc oxide is 0.01 g, and the volume of purified water is 88.24 mL.

[0047] Example 4

[0048] This embodiment provides a method for preparing a light-guiding gel. Compared with Example 1, the differences are: the mass of carbomer is 0.3 g, the mass of glycerin is 2 g, the mass of propylene glycol is 2 g, the mass of ethyl parahydroxybenzoate is 0.05 g, the mass of bisabolol is 0.3 g, the mass of triethanolamine is 0.25 g, and the volume of purified water is 91.58 mL.

[0049] Example 5

[0050] This embodiment provides a method for preparing a light-guiding gel. Compared with Example 1, the differences are: the mass of carbomer is 0.5 g, the mass of glycerin is 5 g, the mass of propylene glycol is 5 g, the mass of ethyl parahydroxybenzoate is 0.2 g, the mass of bisabolol is 0.8 g, the mass of triethanolamine is 0.65 g, and the volume of purified water is 84.33 mL.

[0051] Comparative Example 1

[0052] This comparative example provides a method for preparing a light-guiding gel. Compared with Example 1, the difference is that: polydimethylsiloxane is not contained, and the volume of purified water is 91.23 mL.

[0053] Comparative Example 2

[0054] This comparative example provides a method for preparing a light-guiding gel. Compared with Example 1, the difference is that: no nano zinc oxide is included, and the volume of purified water is 89.25 mL.

[0055] Comparative Example 3

[0056] This comparative example provides a method for preparing a light-guiding gel. Compared with Example 1, the difference is that no bisabolol is contained and the volume of purified water is 89.73 mL.

[0057] Comparative Example 4

[0058] This comparative example provides a method for preparing a light-guiding gel. Compared with Example 1, the differences are: the mass of polydimethylsiloxane is 0.5 g, the mass of nano-zinc oxide is 0.02 g, and the volume of purified water is 90.73 mL.

[0059] Comparative Example 5

[0060] This comparative example provides a method for preparing a light-guiding gel. Compared with Example 1, the differences are: the mass of polydimethylsiloxane is 10 g, the mass of nano-zinc oxide is 0.02 g, and the volume of purified water is 81.23 mL.

[0061] Performance Testing

[0062] Performance tests were performed on Examples 1 to 3 and the comparative example. The differences between the components in the examples and the comparative example are shown in Table 1 below.

[0063] Table 1 Differences between the components in Examples 1 to 3 and Comparative Examples 1 to 5

[0064]

[0065]

[0066] Skin sensitization test: Take the test solution and perform skin test according to the method specified in GB / T 16886.10.

[0067] Transmittance measurement: Cut the light-conducting gel into small pieces measuring 20 mm x 10 mm x 5 mm, place them in a 40 mm x 10 mm x 5 mm cuvette, and then pour distilled water into the cuvette. Measure the transmittance of the gel at 500 nm using a 721B visible spectrophotometer.

[0068] Thermal conductivity test: The thermal conductivity of the light-conducting gel was measured using a TC3000 thermal conductivity meter.

[0069] Comfort test: 10 volunteers aged 25 to 50 were selected and the gels prepared in Examples 1 to 3 and the comparative example were used respectively. The room temperature was controlled at 25°C and used in conjunction with the photon therapy device. The user's experience after use was recorded and the comfort was scored on a scale of 1 to 10. The larger the number, the higher the comfort.

[0070] The performance test results are shown in Table 2 below.

[0071] Table 2 Performance test results

[0072] Skin sensitization test Light transmittance Thermal conductivity (W / (m·K)) Comfort Example 1 ≤Level 1 92.4％ 0.732 8.3 Example 2 ≤Level 1 90.8％ 0.711 8.2 Example 3 ≤Level 1 93.8％ 0.687 7.9 Comparative Example 1 ≤Level 1 86.7％ 0.705 8.6 Comparative Example 2 ≤Level 1 93.3％ 0.659 6.4 Comparative Example 3 ≤Level 1 92.1％ 0.701 7.5 Comparative Example 4 ≤Level 1 88.6％ 0.704 8.3 Comparative Example 5 ≤Level 1 95.7％ 0.708 5.1

[0073] As can be seen from Table 2 above, the Examples and Comparative Examples have no skin sensitization, indicating that the ingredients and compatibility used are safe;

[0074] By comparing the performance test results of Example 1 with Example 2, Example 3, Comparative Example 1, and Comparative Examples 4 to 5, it can be seen that polydimethylsiloxane can improve the transmittance of the prepared light-guiding gel due to its high light transmittance and low scattering properties, but adding too much polydimethylsiloxane will lead to an increase in light transmittance, which may cause local skin temperature to rise, burn the skin, and affect comfort; adding too little polydimethylsiloxane will lead to a decrease in light transmittance.

[0075] By comparing the performance test results of Example 1 with Example 2, Example 3 and Comparative Example 2, it can be seen that the uniform dispersion of nano zinc oxide forms a heat-conducting network, which can improve the thermal conductivity efficiency of the light-conducting gel and avoid the local skin temperature increase caused by the improvement of light-conducting performance, causing discomfort.

[0076] Comparing Example 1 with Comparative Example 3, bisabolol inhibits the release of neuropeptides during photon therapy, reduces the stinging sensation when the photon probe contacts the skin, and improves comfort. At the same time, by inhibiting the release of leukotrienes and interleukin-1, it reduces the inflammatory response caused by photon therapy and relieves skin redness, swelling, and burning sensation.

[0077] In summary, the light-guiding gel provided by the present invention has safe ingredients, reasonable compatibility, can efficiently guide light and disperse local high temperature of the skin.

[0078] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A light-guiding gel, characterized in that: The invention comprises a light guiding agent and nano zinc oxide, wherein the light guiding agent comprises polydimethylsiloxane.

2. The light-guiding gel according to claim 1, wherein: The mass fraction of the polydimethylsiloxane is 1 to 3 wt %, and the mass fraction of the nano zinc oxide is 0.01 to 0.03 wt %.

3. The light-guiding gel according to claim 1, wherein: Also included are thickeners, humectants, preservatives, skin conditioners, pH adjusters, ethanol, and water.

4. The light-guiding gel according to claim 3, wherein: The skin conditioning agent is bisabolol, with a mass fraction of 0.3-0.8 wt%.

5. The light-guiding gel according to claim 3, wherein: The thickener comprises one or more of carbomer, xanthan gum, carboxymethyl cellulose, and hydroxyethyl cellulose, and the mass fraction of the thickener is 0.3-0.5 wt %.

6. The light-guiding gel according to claim 3, wherein: The moisturizing agent comprises one or more of glycerol, propylene glycol, and 1,4-butylene glycol, and the mass fraction of the moisturizing agent is 4-10 wt%.

7. The light-guiding gel according to claim 3, wherein: The preservative includes one or more of methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate and sodium benzoate, and the mass fraction of the preservative is 0.05 to 0.2 wt%.

8. The light-guiding gel according to claim 3, wherein: The pH regulator includes sodium hydroxide and / or triethanolamine, and the mass fraction of the pH regulator is 0.25-0.65 wt%.

9. The method for preparing the light-guiding gel according to any one of claims 1 to 8, wherein: The following steps are involved: S1. Sprinkle the thickener onto the water surface, let it stand until it swells naturally, and then heat and mix to obtain solution A; S2, heating and mixing the moisturizing agent, light guiding agent, preservative and nano zinc oxide to obtain solution B; S3. Add ethanol and skin conditioner and mix well to obtain solution C; S4. Add the solution B and solution C to the solution A, mix well, and dropwise add a pH adjuster to adjust the pH to obtain the light-guiding gel.

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