Heparin sodium dosage dynamic regulation type autologous blood transfusion device

Abstract

A heparin sodium dosage dynamic regulation and control type autologous blood transfusion device comprises a suction pump used for introducing external blood into the device; the impurity removing unit comprises a separating mechanism and a filtering assembly, the input end of the separating mechanism is connected with the output end of the suction pump, and the separating mechanism is used for separating impurities in the blood; the heparin sodium injection unit comprises a heparin sodium infusion linkage pump, the output end of the heparin sodium injection linkage pump is connected with the output end of the impurity removal unit, and the heparin sodium injection unit is used for adding heparin sodium into the blood which is infused back; the controller is electrically connected with the suction pump, the separation mechanism and the heparin sodium injection unit; and the flow sensors are respectively arranged at the output end of the impurity removal unit and the output end of the heparin sodium infusion linkage pump and are electrically connected with the controller. By means of the intelligent and modular design, the efficient, accurate and safe blood transfusion process is achieved. The system has the core advantages of dynamically regulating and controlling the dosage of heparin sodium, monitoring key parameters in real time and multiple safety guarantee mechanisms, and can be widely applied to the fields of operations, first aid, blood purification and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to an autologous blood transfusion device with a dynamic heparin sodium dosage control. Background Art

[0002] Autologous blood transfusion has been widely used in surgical procedures involving massive bleeding or a high risk of transfusion, such as cardiovascular surgery, spinal surgery, hepatosplenic rupture, ectopic pregnancy rupture, and neurosurgery. Commonly used methods for autologous blood transfusion in clinical practice include storage, dilution, and recovery. Studies have shown that autologous blood transfusion offers significant advantages over allogeneic blood transfusion, including a reduced transfusion rate for allogeneic blood and a reduction in adverse transfusion reactions such as fever and hemolysis. Furthermore, because autologous blood is fresh and rich in 2,3-diphosphoglycerate (2,3-DPG), the deformability and oxygen-carrying capacity of red blood cells after transfusion are superior to those of the allogeneic blood group. Furthermore, studies have shown that autologous blood transfusion has no significant effect on the body's coagulation function.

[0003] Furthermore, in heavy bleeding surgeries such as spinal fusion, where blood loss can account for 30% to 100% of the body's total blood volume, blood transfusion is crucial for the successful completion of surgery and can even directly impact the success of the surgery and the patient's prognosis. In recent years, with the widespread use of blood salvage machines and autologous blood transfusion technology, salvaged autologous blood transfusion has become a primary means of blood conservation. This technology promptly recovers the patient's lost blood during surgery, mixes it with sodium heparin, and then, after centrifugation and washing, returns it to the patient. This effectively preserves red blood cells, maintaining the patient's vital signs and the oxygen supply capacity of hemoglobin.

[0004] However, salvaged autologous blood transfusion also has certain limitations. Because it is equivalent to transfusing only red blood cells as components, it can affect coagulation function, increase the risk of perioperative bleeding, and even cause complications such as coagulopathy and postoperative hemorrhage. Furthermore, the dosage of sodium heparin depends on the anesthesiologist's subjective judgment, which can lead to inaccurate dosing. If the dose is insufficient, the transfused blood will coagulate; if the dose is excessive, the transfused blood may become heparinized, resulting in abnormal clotting times.

[0005] Therefore, in view of the shortcomings of the existing technology, it is necessary to design a heparin sodium dosage dynamically regulated autologous blood transfusion device to solve the above problems.

[0006] It should be noted that the above introduction to the technical background is only for the convenience of providing a clear and complete description of the technical solution of the present invention and facilitating the understanding of those skilled in the art. It cannot be assumed that the above contents are well known to those skilled in the art simply because they are explained in the background technology of the present invention. Summary of the Invention

[0007] To overcome the deficiencies in the prior art, the present invention aims to disclose a heparin sodium dosage dynamically regulated autologous blood transfusion device, which can accurately control the heparin sodium dosage, monitor and regulate the blood processing process in real time, and improve the safety and automation of blood transfusion.

[0008] The present invention discloses a heparin sodium dosage dynamically controlled autologous blood transfusion device, comprising: a suction pump for introducing external blood into the device; The impurity removal unit includes a separation mechanism and a filter assembly, wherein the input end of the separation mechanism is connected to the output end of the suction pump and is used to separate impurities in the blood; A heparin sodium injection unit, comprising a heparin sodium infusion linkage pump, the output end of which is connected to the output end of the impurity removal unit, for adding heparin sodium to the reinfused blood; A controller, electrically connected to the suction pump, the separation mechanism, and the sodium heparin injection unit, automatically controls the autologous blood transfusion device based on sensor feedback; The flow sensors are respectively arranged at the output end of the impurity removal unit and the output end of the heparin sodium infusion linkage pump and are electrically connected to the controller for monitoring the flow of blood and heparin sodium.

[0009] Preferred technical solution: The separation mechanism is a centrifuge that separates impurities from the blood through rotation. A filtration assembly is positioned on the periphery of the centrifuge and includes at least one layer of sodium heparin filter membrane. This filter removes the sodium heparin already in the blood, making subsequent high-precision mixing of sodium heparin with blood much simpler.

[0010] Preferred technical solution: The output end of the impurity removal unit is also connected to a constant temperature unit, which includes a heating mechanism for heating the returned blood to a temperature close to the patient's body temperature and a temperature sensor for detecting the temperature of the returned blood. The heating mechanism and the temperature sensor are both electrically connected to the controller.

[0011] Preferred technical solution: The output end of the impurity removal unit is also provided with a pressure sensor for detecting the pressure of the returned blood. The pressure sensor is electrically connected to the controller to ensure the safety of the blood return process.

[0012] Preferred technical solution: The controller is equipped with an AI intelligent control module that can dynamically adjust parameters such as heparin sodium dosage, blood flow rate, and temperature based on real-time monitoring data. The controller is also connected to an alarm mechanism that sounds an alarm when abnormal conditions such as excessive pressure, abnormal temperature, or excessive heparin sodium concentration are detected.

[0013] Preferred technical solution: The suction pump is a speed-adjustable pump that can adjust the blood introduction speed according to the instructions of the controller.

[0014] Preferred technical solution: The heparin sodium injection unit further includes a heparin sodium concentration detection sensor, which is electrically connected to the controller and is used to detect the heparin sodium concentration in the blood in real time and feed the data back to the controller.

[0015] Preferred technical solution: The autologous blood transfusion device is also equipped with a built-in backup power supply to provide backup power support for the device, ensuring that the device can still operate normally in the event of a power outage.

[0016] Preferred technical solution: The controller is also connected to an ACT monitoring system, which includes a micro peristaltic pump for extracting external blood. The output end of the micro peristaltic pump is connected to one end of the detection channel, and the other end of the detection channel is connected to the input end of the separation mechanism. The detection channel is provided with an electrode array for detecting changes in coagulation state, and the electrode array is connected to an impedance analysis module. The impedance analysis module is connected to a capacitive touch screen for displaying its feedback data, which is used for real-time monitoring of the coagulation state of autologous blood.

[0017] Preferred technical solution: The detection channel is also provided with an auxiliary temperature control layer, a nano-titanium dioxide photocatalytic coating for self-cleaning pipelines, and a pressure sensor for detecting blood pressure.

[0018] Due to the application of the above technical solution, the present invention has the following beneficial effects compared with the prior art: 1) The controller is equipped with an AI intelligent control module, which, through the cooperation of multiple types of sensors, can monitor heparin sodium concentration, blood flow rate, temperature, pressure and other data in real time, dynamically adjust the device operating parameters, and improve the safety and efficiency of the blood transfusion process; 2) Filtering the original heparin sodium in the blood through the heparin sodium filter membrane facilitates the subsequent precise control of blood and heparin sodium; 3) Purifying blood using centrifugation and filtration can optimize blood quality and reduce the risk of inflammation; 4) The constant temperature unit includes a heating mechanism and a temperature sensor, which can heat the returned blood to close to the patient's body temperature and monitor the temperature in real time to ensure that the returned blood temperature is appropriate and avoid fluctuations in the patient's body temperature; 5) The ACT monitoring system monitors the coagulation status of autologous blood in real time to ensure the safety of blood transfusion.

[0019] 6) The suction pump is an adjustable speed pump that can adjust the blood introduction speed according to the controller's instructions to meet different clinical needs; 7) Built-in backup power supply ensures that the device can still operate normally in the event of a power outage, ensuring patient safety; 8) The alarm mechanism will sound an alarm when an abnormal situation is detected, reminding medical staff to deal with it in time. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following is a brief introduction to the drawings required for use in the specific embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0021] Figure 1 The present invention is a schematic structural diagram of a heparin sodium dosage dynamically controlled autologous blood transfusion device.

[0022] In the above figures, 1. Suction pump; 2. Impurity removal unit; 21. Separation mechanism; 22. Filter assembly; 3. Sodium heparin injection unit; 4. Controller; 5. Constant temperature unit; 6. ACT monitoring system; 61. Micro peristaltic pump; 62. Detection channel; 7. Autologous blood recovery bag. DETAILED DESCRIPTION

[0023] The following describes the implementation of the present invention through specific embodiments. People skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification.

[0024] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequential order. It should be understood that the data used in this way can be interchanged where appropriate, so that the embodiments of the present application are described here. In addition, the terms "including" and "having" and their synonyms are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0025] In this application, terms such as "upper," "lower," "left," "right," "front," "back," "top," "bottom," "inner," "outer," "center," "vertical," "horizontal," "transverse," and "longitudinal" indicate positions or locations based on the positions or locations shown in the accompanying drawings. These terms are primarily intended to better describe the present invention and its embodiments and are not intended to limit the devices, elements, or components indicated to having a specific orientation, or to being constructed or operated in a specific orientation.

[0026] Furthermore, some of the above terms may be used to express other meanings besides indicating a position or location. For example, the term "on" may also be used to indicate a dependency or connection in certain circumstances. Those skilled in the art will understand the specific meanings of these terms in the present invention based on the specific circumstances.

[0027] Furthermore, the terms "installed," "disposed," "provided with," "connected," "connected," "sleeved," and "fitted" should be interpreted broadly. For example, "connected" can mean a fixed connection, a removable connection, or an integral structure; it can be a mechanical connection or an electrical connection; it can be a direct connection, an indirect connection through an intermediary, or internal communication between two devices, elements, or components. For another example, "fitted" can mean complete or partial contact. Those skilled in the art will understand the specific meanings of these terms in the present invention based on the specific circumstances.

[0028] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments in this application can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0029] Example: like Figure 1 As shown, the present invention discloses a heparin sodium dosage dynamically controlled autologous blood transfusion device, comprising a suction pump 1, an impurity removal unit 2, a heparin sodium injection unit 3, a controller 4, and a flow sensor. The main components of the present invention are described in detail below: like Figure 1 As shown, the suction pump 1 is an adjustable-speed pump that can dynamically adjust the speed of blood suction according to the amount of blood loss at the surgery or trauma site. In this embodiment, for ease of understanding, the recovered blood is represented by an autologous blood bag 7 in the figure. In actual use, the liquid inlet of the suction pump 1 can also be connected to the patient's wound through a catheter to introduce external blood into the autologous blood transfusion device.

[0030] like Figure 1 As shown, the impurity removal unit 2 includes a separation mechanism 21 and a filter assembly 22. The input end of the separation mechanism 21 is connected to the output end of the suction pump 1 to receive the blood sucked into the device by the suction pump 1; the separation mechanism 21 adopts a centrifuge design and can separate solid impurities (such as tissue fragments, blood clots, etc.) in the blood through centrifugal force; the filter assembly 22 is arranged on the periphery of the centrifuge and includes at least one layer of sodium heparin filter membrane for filtering out impurities and sodium heparin in the blood.

[0031] like Figure 1As shown, the heparin sodium injection unit 3 includes a heparin sodium infusion linkage pump, whose output end is connected to the output end of the impurity removal unit 2. The heparin sodium infusion linkage pump dynamically adjusts the injection amount of heparin sodium according to the instruction of the controller 4.

[0032] like Figure 1 As shown, the controller 4 is equipped with an AI intelligent control module, which is electrically connected to the suction pump 1, the separation mechanism 21 and the sodium heparin injection unit 3, and performs dynamic intelligent control on the autologous blood transfusion device according to the feedback from the sensor.

[0033] like Figure 1 As shown, flow sensors are respectively arranged at the output end of the impurity removal unit 2 and the output end of the sodium heparin infusion linkage pump, and are electrically connected to the controller 4 for monitoring and feeding back monitoring data of blood flow and sodium heparin injection amount to the controller 4.

[0034] The method and principle of use of the present invention are as follows: the suction pump 1 is started, and the suction speed is adjusted according to the instructions of the controller 4. The blood in the autologous recovered blood bag 7 is introduced into the impurity removal unit 2. After the blood enters the impurity removal unit 2, it is first centrifuged by the centrifuge 21 to separate solid impurities. Subsequently, the blood passes through the filter component 22 to filter out impurities and residual sodium heparin in the blood; the filtered blood is injected with an appropriate amount of sodium heparin as an anticoagulant through the sodium heparin injection unit 3; during this process, the sodium heparin infusion linkage pump dynamically controls the injection amount of sodium heparin according to the instructions of the controller 4, and the filtered and anticoagulated blood is returned to the patient's body through the catheter. Throughout the entire process, the flow sensor monitors the return process in real time and provides real-time data feedback to the controller 4 to ensure that the ratio of sodium heparin to blood is always within the set range.

[0035] like Figure 1 As shown, the output end of the impurity removal unit 2 is also connected to a constant temperature unit 5. This constant temperature unit 5 includes a heating mechanism and a temperature sensor, both of which are electrically connected to a controller 4. This unit heats the returned blood to a temperature close to human body temperature (approximately 37°C), ensuring that the returned blood is at an appropriate temperature. The temperature sensor monitors the blood temperature in real time and feeds the data back to the controller 4.

[0036] like Figure 1 As shown, the output end of the impurity removal unit 2 is also provided with a pressure sensor for detecting the pressure of the returned blood. The pressure sensor is electrically connected to the controller 4 and is used to monitor and feed back the pressure of the returned blood to the controller 4 to prevent excessive pressure from causing harm to the patient.

[0037] like Figure 1 As shown, the controller 4 is also connected to an alarm mechanism, which will trigger an alarm to alert medical personnel when an abnormal situation is detected.

[0038] like Figure 1As shown, the heparin sodium injection unit 3 further includes a heparin sodium concentration detection sensor, which is electrically connected to the controller 4 to monitor the heparin sodium concentration in the reinfused blood in real time and feed the data back to the controller 4.

[0039] like Figure 1 As shown, the autologous blood transfusion device also has a built-in backup power supply to ensure that the device can still operate normally when the external power supply is interrupted, thereby ensuring the safety of the operation or treatment process.

[0040] like Figure 1 As shown, the controller 4 is also connected to an ACT monitoring system 6, which includes a micro peristaltic pump 61 for extracting external blood. The output end of the micro peristaltic pump 61 is connected to one end of a detection channel 62 made of PDMS material, and the other end of the detection channel 62 is connected to the input end of the separation mechanism 21. An electrode array for detecting changes in coagulation state is provided in the detection channel 62, and the electrode array consists of 64 pairs of interdigitated gold electrodes; the electrode array is connected to an impedance analysis module, which uses an ADuCM350 processor and is connected to a capacitive touch screen for displaying its feedback data, thereby realizing rapid detection of blood coagulation state; the capacitive touch screen can display the ACT trend curve in real time, perform coagulation stage warning, and provide heparin sodium dosage recommendations.

[0041] like Figure 1 As shown, further, the detection channel 62 is also provided with an auxiliary temperature control layer including an integrated Pt1000 thin film sensor, a nano-titanium dioxide photocatalytic coating for self-cleaning pipelines, and a pressure sensor for detecting blood pressure.

[0042] Finally, it should be noted that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent replacements for some of the technical features therein. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A heparin sodium dosage dynamically controlled autologous blood transfusion device, characterized in that: include: A suction pump (1) for introducing external blood into the device; The impurity removal unit (2) comprises a separation mechanism (21) and a filter assembly (22), wherein the input end of the separation mechanism (21) is connected to the output end of the suction pump (1); A heparin sodium injection unit (3) comprises a heparin sodium infusion linkage pump, the output end of which is connected to the output end of the impurity removal unit (2) and is used to add heparin sodium to the reinfused blood; A controller (4) electrically connected to the suction pump (1), the separation mechanism (21) and the sodium heparin injection unit (3); Flow sensors are respectively arranged at the output end of the impurity removal unit (2) and the output end of the heparin sodium infusion linkage pump, and are electrically connected to the controller (4).

2. The heparin sodium dosage dynamically controlled autologous blood transfusion device according to claim 1, characterized in that: The separation mechanism (21) is a centrifuge; the filter assembly (22) is arranged on the periphery of the centrifuge and includes at least one layer of sodium heparin filter membrane.

3. The heparin sodium dosage dynamically controlled autologous blood transfusion device according to claim 1, characterized in that: The output end of the impurity removal unit (2) is also connected to a constant temperature unit (5), and the constant temperature unit (5) includes a heating mechanism and a temperature sensor, and both the heating mechanism and the temperature sensor are electrically connected to the controller (4).

4. The heparin sodium dosage dynamically controlled autologous blood transfusion device according to claim 1, characterized in that: The output end of the impurity removal unit (2) is also provided with a pressure sensor for detecting the pressure of the returned blood, and the pressure sensor is electrically connected to the controller (4).

5. The heparin sodium dosage dynamically controlled autologous blood transfusion device according to claim 1, characterized in that: The controller (4) is equipped with an AI intelligent control module and an alarm mechanism.

6. The heparin sodium dosage dynamically controlled autologous blood transfusion device according to claim 1, characterized in that: The suction pump (1) is a speed-adjustable pump.

7. The heparin sodium dosage dynamically controlled autologous blood transfusion device according to claim 1, characterized in that: The heparin sodium injection unit (3) further includes a heparin sodium concentration detection sensor, and the heparin sodium concentration detection sensor is electrically connected to the controller (4).

8. The heparin sodium dosage dynamically controlled autologous blood transfusion device according to claim 1, characterized in that: The autologous blood transfusion device is also provided with a built-in backup power supply.

9. The heparin sodium dosage dynamically controlled autologous blood transfusion device according to claim 1, characterized in that: The controller (4) is also connected to an ACT monitoring system (6), which includes a micro peristaltic pump (61) for extracting external blood, an output end of the micro peristaltic pump (61) is connected to one end of a detection channel (62), and the other end of the detection channel (62) is connected to the input end of the separation mechanism (21), and an electrode array for detecting changes in coagulation state is provided in the detection channel (62), and the electrode array is connected to an impedance analysis module, and the impedance analysis module is connected to a capacitive touch screen for displaying its feedback data.

10. The heparin sodium dosage dynamically controlled autologous blood transfusion device according to claim 9, characterized in that: The detection channel (62) is also provided with an auxiliary temperature control layer, a nano-titanium dioxide photocatalytic coating for self-cleaning the pipeline, and a pressure sensor for detecting blood pressure.

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