Raman system online detection device for sterile injection intermediate
By redesigning the combination of the safety tank, vacuum generator and compressed air source, the problems of U-shaped tube blockage and insufficient vacuum are solved, and effective cleaning and efficient detection of the Raman system online detection of sterile injection intermediates are achieved.
Patent Information
- Application Number
- CN202510531381.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-25
- Publication Date
- 2025-08-15
AI Technical Summary
In the existing Raman system detection device for sterile injection intermediates, the U-shaped overtracheal pipe is easily blocked by water, resulting in the inability to effectively discharge the gas, affecting the cleaning effect, and insufficient vacuum degree or excessive use of the vacuum generator will lead to insufficient sample volume or contamination.
The fuse tank, vacuum generator and compressed air source were redesigned, the U-shaped tube was cancelled, and the vacuum tank was used to ensure that the vacuum was 100%, and the gas flow was controlled through solenoid valves and pressure reducing valves to avoid the accumulation of sample liquid at the vacuum generator. A sample detection tube made of stainless steel and a circulation pump were used to improve detection accuracy.
It solves the problem of U-shaped tube blockage, ensures effective gas discharge, avoids sample contamination and insufficient quantity, and improves the accuracy and efficiency of detection.
Smart Images
Figure CN120490040A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of content detection of sterile injection intermediates, in particular to an online detection device for a Raman system of sterile injection intermediates. Background Art
[0002] As a drug that is directly infused into the human bloodstream, the safety of sterile injections is of paramount importance. During the synthesis process, injection intermediates may undergo various reactions that could affect product safety.
[0003] For the content determination of the prepared injection intermediate, Raman system detection devices are currently commonly used for detection. Existing detection devices such as Figure 1 As shown in the figure, the sample liquid to be tested is injected into a glass bottle. The glass bottle is equipped with signal detection components such as a Raman probe and pH electrode, as well as a U-shaped air passage. After the test is completed, the glass bottle needs to be cleaned by injecting water into it and then draining the water. The U-shaped air passage only allows air to pass through, not water, and is used to guide the gas in the glass bottle to the outside for easy drainage. However, if there is a large amount of water in the glass bottle, some water will enter the U-shaped air passage, causing a blockage, preventing the gas from being discharged and affecting the effective discharge of the cleaning water.
[0004] In view of this, this patent application is filed. Summary of the Invention
[0005] In view of the above content, in order to solve the problems existing in the prior art, the present invention provides an online detection device for a Raman system of a sterile injection intermediate.
[0006] The technical solution is a Raman system online detection device for sterile injection intermediates, including a sample detection tube, a vacuum generator, a compressed air source, and a safety tank. The upper end outlet of the sample detection tube is connected to the safety tank, and the safety tank is connected to the vacuum generator. The gas outlet of the compressed air source is respectively connected to the gas inlet of the vacuum generator and the gas inlet of the safety tank. The lower end of the sample detection tube is connected to a waste liquid discharge pipe.
[0007] In an optional embodiment, a solenoid valve A and a pressure reducing valve are provided on the connecting pipeline between the compressed air source and the fuse tank.
[0008] In an optional embodiment, a solenoid valve B is provided on the connecting pipeline between the sample detection tube and the safety tank, a solenoid valve C is provided on the waste liquid discharge pipe, and a solenoid valve D is provided on the connecting pipeline between the compressed air source and the vacuum generator.
[0009] In an optional embodiment, the sample detection tube is made of stainless steel.
[0010] In an optional embodiment, the sample detection tube is provided with a signal detection component, and the signal detection component includes a Raman probe, a pH electrode, and a temperature sensor, and the Raman probe, pH electrode, and temperature sensor are all installed on the sample detection tube.
[0011] In an optional embodiment, two temperature sensors are provided, located at two ends of the sample detection tube respectively.
[0012] In an optional embodiment, a circulation pump is connected in parallel to the sample detection tube.
[0013] In an optional embodiment, a detection liquid inlet is provided on the sample detection tube, and a solenoid valve E is provided on the detection liquid inlet.
[0014] In an optional embodiment, a standard liquid inlet is further included, and the standard liquid inlet is connected to the lower end of the sample detection tube.
[0015] In an optional embodiment, a ball valve is provided between the standard liquid inlet and the sample detection tube.
[0016] 1. The present invention provides an online detection device for a Raman system of sterile injection intermediates. The U-shaped tube in the existing detection device is eliminated, and the safety tank, vacuum generator and compressed air source are redesigned. The technical problem of U-shaped tube blockage is solved by the coordination of various components.
[0017] 2. The present invention provides an online detection device for a Raman system of sterile injection intermediates. By designing a safety tank, the vacuum generation degree can be guaranteed to be around 100%, so as to ensure that the sample liquid level can be sucked into the sample detector to meet the sample volume requirement. It can also avoid the accumulation of sample liquid at the vacuum generator when the liquid volume exceeds the maximum volume of the sample detector, thereby avoiding sample contamination. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] Figure 1 This is a schematic diagram of the structure of the existing sterile injection intermediate Raman system detection device;
[0019] Figure 2 This is a structural schematic diagram of a Raman system online detection device for sterile injection intermediates provided by the present invention.
[0020] In the picture:
[0021] 1-sample test tube, 2-vacuum generator, 3-compressed air source, 4-safety tank, 5-Raman probe, 6-pH electrode, 7-temperature sensor, 8-circulation pump, 9-test liquid inlet, 10-standard liquid inlet, 11-waste liquid discharge pipe, 12-solenoid valve A, 13-solenoid valve B, 14-solenoid valve C, 15-solenoid valve D, 16-solenoid valve E, 17-ball valve, 18-pressure reducing valve. DETAILED DESCRIPTION
[0022] The following will clearly and completely describe the technical solutions of various embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention. In the description of the present invention, it should be noted that the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicate directions or positional relationships based on the directions or positional relationships shown in the accompanying drawings, which are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present invention.
[0023] In addition, the terms "first," "second," and "third" are used for descriptive purposes only and should not be understood as indicating or implying relative importance. In the description of the present invention, it should be noted that, unless otherwise expressly specified or limited, the terms "installed," "connected," and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; and they can refer to internal connections between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention according to specific circumstances.
[0024] The present invention will be further described in detail below through specific implementation examples in conjunction with the accompanying drawings.
[0025] Example 1:
[0026] like Figure 2 As shown in the figure, a Raman system online detection device for sterile injection intermediates includes a sample detection tube 1, a vacuum generator 2, a compressed air source 3, and a safety tank 4.
[0027] The sample test tube 1 is used to hold a liquid sample of the injectable intermediate to be tested. The upper outlet of the sample test tube 1 is connected to a safety canister 4. The safety canister 4 is hollow and can hold a portion of the test sample, as well as air. The safety canister 4 is connected to a vacuum generator 2. The gas outlet of a compressed air source 3 is connected to the gas inlets on the vacuum generator 2 and the safety canister 4, respectively, allowing compressed gas to enter the vacuum generator 2 and the safety canister 4. A waste liquid discharge pipe is connected to the lower end of the sample test tube 1.
[0028] During testing, compressed gas is turned on and enters the vacuum generator 2 to generate negative pressure, thereby drawing out the gas in the sample test tube 1 and the safety tank 4, allowing the sample liquid to be tested to smoothly enter the sample test tube 1. When the sample test tube 1 needs to be cleaned, clean water is entered into the sample test tube 1 for cleaning. After the cleaning is completed, compressed gas enters the safety tank 4, applying pressure to the gas in the safety tank 4, thereby squeezing the gas in the safety tank 4 and the gas in the connecting pipe between the sample test tube 1 and the safety tank 4 to apply pressure to the interior of the sample test tube 1, forcing the cleaning waste liquid to flow downward and be discharged from the waste liquid discharge pipe.
[0029] In this embodiment, the U-shaped tube in the existing detection device is eliminated, and the safety tank 4, vacuum generator 2 and compressed air source 3 are redesigned. The technical problem of the U-shaped tube being blocked is solved by the cooperation of various components.
[0030] In this embodiment, since the sample detector is fully enclosed, a vacuum generator 2 is added above it to displace the air in the sample detector. However, in actual use, the vacuum generator 2 only achieves a vacuum level of approximately 85%, which can result in insufficient sample volume being introduced into the sample detector, affecting test accuracy. Furthermore, if the vacuum generator 2 were activated a second time, excessive sample volume could enter the upper airway from above the sample detector, potentially leading to sample contamination. Therefore, a safety canister 4 is provided in this embodiment to maintain a vacuum level of approximately 100%, ensuring that the sample liquid level can be drawn into the sample detector at this vacuum level, meeting the sample volume requirement. If the vacuum generator 2 draws liquid and the liquid volume exceeds the maximum capacity of the sample detector, the safety canister 4 effectively prevents the liquid from entering the airway, preventing accumulation of the sample solution at the vacuum generator 2 and potentially causing sample contamination.
[0031] Preferably, a solenoid valve A12 and a pressure reducing valve 18 are provided on the connecting pipeline between the compressed air source 3 and the safety tank 4. The solenoid valve A12 controls whether the compressed gas enters or not, while the pressure reducing valve 18 reduces the impact caused by the gas entering the safety tank 4.
[0032] To better control the flow of liquid in the device's pipelines, a solenoid valve B13 is installed on the pipeline connecting the sample detection tube 1 and the fuse tank 4, a solenoid valve C14 is installed on the waste liquid discharge pipe, and a solenoid valve D15 is installed on the pipeline connecting the compressed air source 3 and the vacuum generator 2. The opening and closing of each valve and the degree of opening control the flow of liquid.
[0033] Since the sample detection tube 1 needs to be sterilized after cleaning, and the life of the glass bottle in the existing device will be significantly shortened after long-term high-temperature baking, the sample detection tube 1 in this embodiment is made of stainless steel, such as 316 material, which can better withstand high-temperature environments.
[0034] In this embodiment, a signal detection assembly is provided on the sample detection tube 1. The signal detection assembly includes a Raman probe 5, a pH electrode 6, and a temperature sensor 7. These components are all mounted on the sample detection tube 1. Preferably, two temperature sensors 7 are provided, one at each end of the sample detection tube 1. Of course, more temperature sensors 7 may be provided. This arrangement allows for detecting the temperature of the sample liquid at various locations within the sample detection tube 1, enabling temperature compensation and improving the accuracy of the detection results.
[0035] In order to further improve the accuracy of the sample concentration test, a circulation pump 8 is connected in parallel to the sample detection tube 1. Figure 2 As shown in the figure, the upper and lower ends of the sample detection tube 1 are respectively connected to the liquid flow ports of the circulation pump 8. The purpose is to circulate the liquid in the sample detection tube 1 through the circulation pump 8 during the detection process to make the liquid temperature more uniform.
[0036] The sample test tube 1 is provided with a test liquid inlet 9, through which the sample liquid to be tested enters. This inlet is equipped with a solenoid valve E16. It also includes a standard liquid inlet 10, which connects to the lower end of the sample test tube 1. A ball valve 17 is installed between the standard liquid inlet 10 and the sample test tube 1. The valve controls the flow of liquid. The standard liquid inlet 10 is designed for use in calibrating the pH electrode 6.
[0037] The present invention has been described in detail above by way of specific embodiments and examples, but these do not constitute limitations of the present invention. Without departing from the principles of the present invention, those skilled in the art may make many variations and improvements, which should also be considered within the scope of protection of the present invention.
Claims
1. A Raman system online detection device for sterile injection intermediates, characterized in that: The invention comprises a sample detection tube (1), a vacuum generator (2), a compressed air source (3), and a safety tank (4); the upper end outlet of the sample detection tube (1) is connected to the safety tank (4), the safety tank (4) is connected to the vacuum generator (2), the gas outlet of the compressed air source (3) is connected to the gas inlet of the vacuum generator (2) and the gas inlet of the safety tank (4), respectively, and the lower end of the sample detection tube (1) is connected to a waste liquid discharge pipe.
2. The Raman system online detection device for sterile injection intermediates according to claim 1, characterized in that: A solenoid valve A (12) and a pressure reducing valve (18) are provided on the connecting pipeline between the compressed air source (3) and the safety tank (4).
3. The Raman system online detection device for sterile injection intermediates according to claim 1, characterized in that: A solenoid valve B (13) is provided on the connecting pipeline between the sample detection tube (1) and the safety tank (4), a solenoid valve C (14) is provided on the waste liquid discharge pipe, and a solenoid valve D (15) is provided on the connecting pipeline between the compressed air source (3) and the vacuum generator (2).
4. The Raman system online detection device for sterile injection intermediates according to claim 1, characterized in that: The sample detection tube (1) is made of stainless steel.
5. The Raman system online detection device for sterile injection intermediates according to claim 1, characterized in that: The sample detection tube (1) is provided with a signal detection component, which includes a Raman probe (5), a pH electrode (6), and a temperature sensor (7); the Raman probe (5), the pH electrode (6), and the temperature sensor (7) are all installed on the sample detection tube (1).
6. The Raman system online detection device for sterile injection intermediates according to claim 5, characterized in that: Two temperature sensors (7) are provided, and are respectively located at the two ends of the sample detection tube (1).
7. The Raman system online detection device for sterile injection intermediates according to claim 1, characterized in that: A circulation pump (8) is connected in parallel to the sample detection tube (1).
8. The Raman system online detection device for sterile injection intermediates according to claim 1, characterized in that: The sample detection tube (1) is provided with a detection liquid inlet (9), and the detection liquid inlet (9) is provided with a solenoid valve E (16).
9. The Raman system online detection device for sterile injection intermediates according to claim 1, characterized in that: It also includes a standard liquid inlet (10), and the standard liquid inlet (10) is connected to the lower end of the sample detection tube (1).
10. The Raman system online detection device for sterile injection intermediates according to claim 9, characterized in that: A ball valve (17) is provided between the standard liquid inlet (10) and the sample detection tube (1).