Radioactive drug split charging equipment and split charging method

Abstract

The invention discloses radiopharmaceutical split charging equipment and a split charging method. The equipment comprises an upper shell and a lower shell, a base used for containing a stock solution bottle distribution tank is arranged at the bottom of the lower shell, a cover opening mechanism used for opening a tank cover of the stock solution bottle distribution tank and a needling mechanism used for extracting stock solution in a stock solution bottle are arranged above the base, and a horizontal sliding mechanism is arranged at the bottom of the base. The driving mechanism is used for driving the base to slide to the position under the uncovering mechanism and the needling mechanism. A stock solution extracting needle is fixed to the needling mechanism and used for extracting stock solution in a stock solution bottle and then transferring the stock solution into a liquid medicine diluting bottle in the upper shell, and then split charging is achieved through a liquid medicine split charging and transferring guide pipe in the upper shell. Opening of a stock solution bottle distribution tank and extraction of stock solution in a stock solution bottle can be sequentially achieved in the lower shell through the uncovering mechanism and the needling mechanism, the stock solution distribution tank and the stock solution in the stock solution bottle can be matched with a liquid medicine subpackaging and transferring guide pipe in the upper shell, all-directional protection subpackaging is achieved, the protection effect in the whole process is good, and harm to medical staff is greatly reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of radioactive drug packaging, and in particular to radioactive drug packaging equipment and a packaging method. Background Art

[0002] Radiopharmaceuticals are specialized drugs containing radioactive nuclides for use in medical diagnosis and treatment, such as I-131 radiotherapy for hyperthyroidism patients. Radiopharmaceuticals require subpackaging for clinical use. Currently, many radiopharmaceuticals are dispensed and packaged using syringes. This process is time-consuming, difficult, and imprecise, failing to meet the precise needs of each patient and compromising treatment and examination outcomes. Furthermore, the subpackaging process exposes operators to prolonged radiation exposure, posing significant risks to medical staff.

[0003] At present, there are also packaging equipment for radioactive drugs on the market, but there are still problems such as incomplete packaging steps, poor shielding effect, residual radioactive drugs, inaccurate packaging, inconvenient operation, and difficult disassembly and assembly. This application is based on this and creates a new radioactive drug packaging equipment and packaging method, which at least overcomes one or more of the shortcomings of the above-mentioned existing packaging equipment, meets market needs, and becomes a goal that the industry urgently needs to improve. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a radioactive drug packaging equipment that can completely complete the packaging of the original liquid from the original liquid bottle to the drug dilution bottle and then to the drug receiving bottle. The entire process has good protection effect, accurate packaging, convenient operation and easy maintenance, thereby overcoming the shortcomings of existing radioactive drug packaging equipment.

[0005] In order to solve the above technical problems, the present invention provides a radiopharmaceutical packaging device, including an upper shell, wherein the upper shell is provided with a bottle protective cover for placing a liquid medicine dilution bottle, a packaging protective cover for installing a liquid medicine packaging transfer tube, and a cup holder mechanism for placing a liquid medicine receiving cup, as well as a driving mechanism for driving the syringe connected to the liquid medicine packaging transfer tube to be plugged in and out and moved, and the liquid medicine packaging transfer tube includes at least three three-way valves connected in series, the ends of the three-way valves are respectively connected to the syringe, the diluent extraction needle, the original liquid extraction needle, the drinking water extraction tube and the liquid medicine discharge tube, and further includes a syringe located below the upper shell. The lower shell body has a base for placing the stock liquid bottle delivery tank at the bottom of the lower shell body, and an opening mechanism for opening the lid of the stock liquid bottle delivery tank and a needling mechanism for extracting the stock liquid in the stock liquid bottle are provided above the base. The bottom of the base is provided with a horizontal sliding mechanism for driving the base to slide to the bottom of the opening mechanism and the needling mechanism respectively, so as to realize the opening of the lid of the stock liquid bottle delivery tank and the extraction of the stock liquid in the stock liquid bottle in turn; a stock liquid extraction needle is fixed on the needling mechanism, which is used to extract the stock liquid in the stock liquid bottle and transfer it to the drug dilution bottle through the drug liquid subpackaging transfer catheter.

[0006] Further improvement, the upper shell also includes a diaphragm pump, a solenoid valve and a ventilation needle, the air inlet end of the diaphragm pump is connected to the first port of the solenoid valve, the second port of the solenoid valve is connected to the ventilation needle, and the third port of the solenoid valve is connected to the internal space of the upper shell. When the solenoid valve is energized, its first port is communicated with the second port. The start-up of the diaphragm pump can form a negative pressure inside the medicine dilution bottle, and the original liquid in the original liquid bottle enters the medicine dilution bottle under the action of negative pressure; when the solenoid valve loses power, its third port is communicated with the second port, thereby realizing the communication between the medicine dilution bottle and the internal space of the upper shell, which is convenient for the syringe connected to the medicine liquid filling transfer catheter to extract the medicine in the medicine dilution bottle.

[0007] As a further improvement, the packaging equipment is also provided with a hanging hole for hanging a syringe for flushing medicine liquid, the syringe for flushing medicine liquid is used to be filled with flushing liquid and air, the outlet end of the syringe for flushing medicine liquid is connected to a gas-liquid introduction needle through a catheter, and the gas-liquid introduction needle is inserted into the stock liquid bottle through the acupuncture mechanism. When the diaphragm pump is started to extract the stock liquid in the stock liquid bottle, the flushing liquid and air in the syringe for flushing medicine liquid are sucked into the stock liquid bottle in turn by the negative pressure, thereby realizing the extraction of the stock liquid in the stock liquid bottle and the flushing of the stock liquid bottle at one time.

[0008] Further improvements are made in that the medicine bottle protective cover is surrounded by a top lead cover, a bottom lead seat and four side lead blocks, the inner walls of the side lead blocks are provided with activity detectors for detecting the activity of the medicine dilution bottle, the side lead blocks near the middle of the upper shell are provided with a first avoidance hole for the conduit passing through the medicine bottle protective cover, the top lead cover is opened and closed in a push-pull manner, and the upper shell is provided with a locking pin for controlling the opening and closing sliding of the top lead cover.

[0009] As a further improvement, a second avoidance hole is provided on the side lead block near the outside of the upper shell for the catheter connected to the raw liquid extraction needle to pass through, and a hose protective cover is also provided on the outside of the upper shell for protecting the catheter connected to the raw liquid extraction needle before it enters the second avoidance hole.

[0010] As a further improvement, the upper shell also includes an independent three-way valve whose first port is connected to the drinking water extraction pipe, the second port of the independent three-way valve is connected to a port in the liquid medicine packaging transfer conduit, and the third port of the independent three-way valve is blocked.

[0011] Further improvement, the cup holder mechanism includes a cup holder for placing a medicine liquid receiving cup, a hose holder and a three-link rod for installing a medicine liquid discharge pipe, and a power mechanism for driving the cup holder to telescope and move. The middle part of the hose holder is rotatably fixed to the vertical plate located in the upper shell through a pin shaft, and the outer end of the hose holder is arranged into an L-shaped structure. The three-link rod includes a horizontal push block, a triangular block and a vertical rod. The outer end of the horizontal push block is abutted against the inner side of the cup holder, and the other end is hinged to the first corner end of the triangular block. The second corner end of the triangular block is rotatably connected to the vertical plate, the third triangular end of the triangular block is hinged to the bottom end of the vertical rod, the top end of the vertical rod is hinged to the inner end of the hose holder, and the inner end of the hose holder is also connected A return spring, the other end of which is connected to the bottom of the vertical plate. When the cup holder moves inward under the action of the power mechanism, it drives the horizontal push block to move inward, pushes the triangular block to rotate, and then pushes the vertical rod to move upward, prompting the inner end of the hose rack to rotate upward, and then the outer end of the hose rack to rotate downward, driving the outlet end of the liquid medicine discharge pipe close to the inner wall of the liquid medicine receiving cup to prevent splashing when the liquid medicine is discharged; when the cup holder extends outward, the return spring rebounds to prompt the inner end of the hose rack to rotate downward, and then the outer end of the hose rack to rotate upward to above the liquid medicine receiving cup, without affecting the liquid medicine receiving cup extending outward with the cup holder.

[0012] Further improved, the cover opening mechanism includes a first sliding shaft fixed to the inside of the lower shell, a sliding base that slides up and down along the first sliding shaft, a cover opening operating handle connected to the edge of the sliding base, and an opening and closing unit provided on the sliding base; the cover opening operating handle extends out of a first vertical sliding groove on the lower shell, and an open cover locking member for locking the cover opening operating handle is provided at the upper end of the first vertical sliding groove;

[0013] The opening and closing unit includes an opening and closing operating lever, an opening and closing slider, an opening and closing connecting rod and an opening and closing hook. Two pins are provided in the middle of the opening and closing operating lever, the first pin is rotatably connected to the sliding base, and the second pin is arranged in the central long hole of the opening and closing slider. The upper part of the opening and closing slider is connected to the upper part of the sliding base through a first spring, and the two sides of the lower part of the opening and closing slider are respectively connected to an opening and closing connecting rod, and the lower end of the opening and closing connecting rod is respectively connected to an opening and closing hook, and the lower end of the opening and closing hook is provided with a barb, and the upper end thereof is provided with two The outer connection point is hinged to the lower end of the opening and closing link, and the inner connection point is hinged to the sliding base. The two opening and closing hooks are arranged opposite to each other. Under the elastic force of the first spring, the opening and closing slider pushes the two lower end hooks of the opening and closing hooks to tighten, so as to grasp the tank cover of the raw liquid bottle delivery tank, lift it and clamp it, and when the opening and closing operating lever drives the opening and closing slider to move upward under the action of external force, the two opening and closing connecting rods drive the lower end hooks of the two opening and closing hooks to expand, thereby releasing the tank cover.

[0014] Further improvement, the opening and closing unit also includes a locking unit, which includes a locking plate fixed on the upper part of the first sliding shaft, and a locking block fixed on the inner end of the opening and closing operating rod, and a locking space is formed between the bottom of the locking plate and the first sliding shaft. When the opening and closing operating rod is not subject to external force, the locking block can enter the locking space with the sliding base plate to lock the opening and closing operating rod.

[0015] As a further improvement, the cover opening mechanism also includes a cover opening limit unit, which includes a cover opening limit rod fixed to the bottom of the sliding base, and a limit hole arranged on the base. When the cover opening limit rod moves downward with the sliding base, it can be inserted into the limit hole to ensure that the cover opening mechanism can achieve the opening positioning of the tank cover and the locking of the cover opening position.

[0016] Further improvement, the acupuncture mechanism includes a second sliding shaft fixed to the inside of the lower shell, an acupuncture operating handle sliding up and down along the second sliding shaft, and a needle holder base plate, the second sliding shaft is also sleeved with a second spring, the upper end of the second spring is connected to the acupuncture operating handle, the lower end of the second spring is connected to the needle holder base plate, the acupuncture operating handle extends out of the second vertical slide groove on the lower shell, and the upper end of the second vertical slide groove is provided with an acupuncture locking member for locking the acupuncture operating handle; the needle holder base plate is used to fix the stock liquid extraction needle and the gas-liquid introduction needle, and the needle ends of the stock liquid extraction needle and the gas-liquid introduction needle are both arranged vertically downward;

[0017] The acupuncture mechanism further includes a acupuncture limiting unit, which includes a acupuncture limiting rod fixed to the needle holder base plate. When the acupuncture limiting rod moves downward with the needle holder base plate, it can be inserted into the limiting hole on the base to ensure that the acupuncture mechanism can achieve acupuncture positioning of the stock solution bottle and lock the acupuncture position.

[0018] When the acupuncture mechanism is located at the bottom, the bottom end of the acupuncture limiting rod just touches the upper surface of the base, and at this time, the needle tip of the stock solution extraction needle just touches the bottom of the stock solution bottle.

[0019] As another improvement of the present invention, the present invention further provides a radiopharmaceutical packaging method, which uses the above-mentioned radiopharmaceutical packaging equipment and includes the following steps:

[0020] (1) Install the stock solution bottle delivery tank, the syringe for flushing the liquid, the stock solution extraction needle, the gas-liquid introduction needle, the liquid dilution bottle, the diluent extraction needle, the ventilation needle, the liquid sub-packaging transfer catheter and syringe, the drinking water bottle and the liquid receiving cup, and complete the corresponding catheter connections;

[0021] (2) The lid of the liquid dispensing bottle is opened by the lid opening mechanism, and the opened liquid dispensing bottle is moved to the bottom of the puncture mechanism by the horizontal sliding mechanism, and the liquid dispensing bottle is punctured by the puncture mechanism;

[0022] (3) Start the diaphragm pump and the solenoid valve, and transfer the stock solution in the stock solution bottle and the cleaning solution in the syringe for flushing the drug solution into the drug solution dilution bottle at one time through the negative pressure generated by the diaphragm pump. After the transfer is completed, close the diaphragm pump and the solenoid valve;

[0023] (4) Based on the patient's demand for liquid medicine and the activity value of the liquid medicine in the liquid medicine dilution bottle, the liquid medicine in the liquid medicine dilution bottle is extracted by a syringe connected to the liquid medicine dispensing transfer catheter, and the extracted liquid medicine is discharged into the liquid medicine receiving cup through the liquid medicine discharge tube;

[0024] (5) Then, the drinking water in the drinking water bottle is extracted through a syringe connected to the liquid medicine dispensing transfer catheter, and the extracted drinking water is discharged into the liquid medicine receiving cup through the liquid medicine discharge pipe;

[0025] (6) Open the door of the upper shell, and the cup holder mechanism sends the medicine liquid receiving cup out of the upper shell, completing the medicine liquid packaging for the patient to drink.

[0026] After adopting such a design, the present invention has at least the following advantages:

[0027] 1. The radiopharmaceutical dispensing equipment of the present invention is equipped with a lid opening mechanism and a puncture mechanism corresponding to the bulk liquid bottle delivery tank. This mechanism can sequentially open the bulk liquid bottle delivery tank and extract the bulk liquid from the bulk liquid bottle within the lower housing. This mechanism can then be connected to the liquid dispensing transfer conduit in the upper housing, achieving all-round protective dispensing of radiopharmaceuticals. The entire process provides excellent protection and significantly reduces hazards to medical personnel.

[0028] 2. A diaphragm pump and solenoid valve are installed in the upper housing, allowing it to automatically draw the original solution from the original solution bottle using negative pressure, while also extracting the diluted solution from the dilution bottle. This scientific and rational design allows for more precise packaging. A syringe for flushing the solution not only allows for the extraction of the original solution but also allows for a single flush of the original solution bottle and pipelines, further reducing residual radiation from radioactive drugs and providing increased safety.

[0029] 3. Improvements to the bottle shield eliminate the need for the existing perforated protective cover, preventing contamination. The top lead cover is configured as a horizontal push-pull structure, allowing operation by simply pushing and pulling it horizontally, eliminating the drawback of the existing protective cover requiring rotation and lifting. This saves time and effort, significantly improving operational convenience and safety. The hose shield further enhances protection for the conduit running between the upper and lower shells, making it safer and more reliable.

[0030] 4. The setting of an independent three-way valve facilitates disassembly, which is convenient for meeting the sub-packaging scene structure layout in existing small spaces, with flexible settings and wide adaptability.

[0031] 5. Improvements to the cup holder mechanism allow the liquid medicine receiving cup to be linked to the liquid medicine discharge tube. The discharge port of the discharge tube is designed to rest against the inner wall of the receiving cup during discharge, allowing the liquid to flow smoothly downward, effectively preventing splashing and further enhancing safety. A return spring also ensures that the hose holder automatically returns to its original position when the cup holder is extended, preventing it from interfering with the movement of the liquid medicine receiving cup.

[0032] 6. The cooperation between the lid opening operating handle and the opening and closing unit in the lid opening mechanism can realize the opening and clamping of the tank lid of the raw liquid bottle distribution tank, and the setting of the locking unit can ensure the clamping of the tank lid after opening to prevent it from falling; the setting of the lid opening limit unit can ensure the positioning of the tank lid opening position and realize the locking of the lid opening position to prevent the raw liquid bottle from shifting when opening the lid.

[0033] 7. Furthermore, the puncture mechanism incorporates a puncture handle and a needle holder baseplate, along with a second spring positioned between them. The spring's elastic force provides a buffering effect, ensuring both puncture of the soft stopper of the bottle and a buffered bottom during extraction. This ensures clean extraction while effectively preventing damage to the bottle bottom from the needle tip. The puncture limiter also ensures accurate positioning of the puncture site within the bottle and locks the puncture site.

[0034] 8. The radiopharmaceutical packaging method of the present invention utilizes a diaphragm pump to generate negative pressure to extract and transfer the stock solution in the stock solution bottle. It also utilizes a syringe for flushing the drug solution to not only extract the stock solution but also flush the stock solution bottle and pipeline at one time, thereby greatly reducing the radiation residue of the radiopharmaceutical, being safer and more scientifically configured. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The above is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0036] Figure 1 It is a right side structural perspective view of the radiopharmaceutical packaging equipment of the present invention.

[0037] Figure 2 It is a left side structural perspective view of the radiopharmaceutical packaging equipment of the present invention.

[0038] Figure 3 It is a perspective view of the rear structure of the radiopharmaceutical packaging equipment of the present invention.

[0039] Figure 4 It is a schematic diagram of the top structure of the radiopharmaceutical packaging equipment of the present invention.

[0040] Figure 5 It is a structural schematic diagram of the electromagnetic valve in the radiopharmaceutical packaging equipment of the present invention when it is energized.

[0041] Figure 6 It is a structural schematic diagram of the electromagnetic valve in the radiopharmaceutical packaging equipment of the present invention when power is lost.

[0042] Figure 7 It is a structural schematic diagram of the transfer of the stock solution in the radiopharmaceutical packaging equipment of the present invention.

[0043] Figure 8 It is a structural schematic diagram of transferring the medicinal solution in the medicinal solution dilution bottle in the radiopharmaceutical packaging equipment of the present invention.

[0044] Figure 9 It is a structural schematic diagram of water transfer in a drinking water bottle in the radiopharmaceutical packaging equipment of the present invention.

[0045] Figure 10 It is a structural schematic diagram of the medicine bottle protective cover in the radiopharmaceutical packaging equipment of the present invention.

[0046] Figure 11 The present invention is a schematic diagram of the radiopharmaceutical packaging equipment with the protective cover of the medicine bottle in the open state.

[0047] Figure 12 This is a schematic diagram of the radiopharmaceutical packaging equipment of the present invention after the protective cover of the medicine bottle is opened.

[0048] Figure 13 It is a structural schematic diagram of the cup holder mechanism in the radiopharmaceutical packaging equipment of the present invention.

[0049] Figure 14 It is a structural schematic diagram of the cup holder mechanism in the radiopharmaceutical packaging equipment of the present invention (showing the drug solution outflow state).

[0050] Figure 15 It is a structural schematic diagram of opening the can lid by the lid opening mechanism in the radiopharmaceutical packaging equipment of the present invention.

[0051] Figure 16 It is a structural schematic diagram of the lid opening mechanism in the radiopharmaceutical packaging equipment of the present invention, which is locked after opening the lid of the can.

[0052] Figure 17 It is a structural schematic diagram of the acupuncture mechanism in the radiopharmaceutical packaging equipment of the present invention.

[0053] Figure 18 It is a structural schematic diagram of the acupuncture mechanism of the radiopharmaceutical packaging equipment of the present invention piercing into the stock solution bottle. DETAILED DESCRIPTION

[0054] Exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although exemplary embodiments of the present invention are shown in the accompanying drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided to enable a more thorough understanding of the present invention and to fully convey the scope of the present invention to those skilled in the art.

[0055] Refer to the attached Figures 1 to 4 As shown, the radiopharmaceutical packaging equipment of this embodiment includes an upper shell 1 and a lower shell 2, and a roller 3 is provided at the bottom of the lower shell 2 for easy movement.

[0056] The upper shell 1 is internally provided with a medicine bottle shield 25 for placing a medicine liquid dilution bottle 26, a sub-packaging shield 19 for mounting a medicine liquid sub-packaging transfer conduit 15, a cup holder mechanism 12 for placing a medicine liquid receiving cup 13, and a drive mechanism 17 for driving the insertion, removal, and movement of a syringe 16 connected to the medicine liquid sub-packaging transfer conduit 15. In this embodiment, the medicine liquid sub-packaging transfer conduit 15 utilizes three three-way valves connected in series and one independent three-way valve 43 connected in series. The ends of the three-way valves in series are respectively connected to the syringe 16, the diluent extraction needle 21, the stock solution extraction needle 31, the drinking water extraction tube 27, and the medicine liquid discharge pipe 14. The upper shell 1 also includes an exhaust pipe 20 with an exhaust fan 18, which is used to connect to the exhaust gas collection pipe to achieve centralized collection and treatment of polluted air inside the upper shell 1.

[0057] The upper housing 1 in this embodiment further includes a diaphragm pump 37, a solenoid valve 38 and a vent needle 23. Figure 5 and 6 As shown, the air inlet end of the diaphragm pump 37 is connected to the first port C of the solenoid valve 38, the second port A of the solenoid valve 38 is connected to the vent needle 38, and the third port B of the solenoid valve 38 is connected to the internal space of the upper shell 1. When the solenoid valve 38 is energized, its first port C is connected to the second port A, and the diaphragm pump 37 is started to form a negative pressure inside the liquid dilution bottle 26. The original liquid in the original liquid bottle 32 enters the liquid dilution bottle 26 under the action of the negative pressure. Figure 7 As shown; when the solenoid valve 38 loses power, its third port B is connected to the second port A, so that the liquid dilution bottle 26 is connected to the internal space of the upper shell 1, which facilitates the extraction of the liquid from the liquid dilution bottle 26 by the syringe 16 connected to the liquid dispensing transfer conduit 15, as shown in the attached Figure 8 In this embodiment, the diaphragm pump 37 and the electromagnetic valve 38 are arranged on the outside of the medicine bottle protective cover 25 , and the connecting conduit between the electromagnetic valve 38 and the ventilation needle 23 passes through the side wall of the medicine bottle protective cover 25 .

[0058] The bottom of the lower shell 2 is provided with a base 34 for placing the stock liquid bottle delivery tank 33, and above the base 34 are provided with a cover opening mechanism 39 for opening the stock liquid bottle delivery tank lid 40 and a needling mechanism 29 for extracting the stock liquid in the stock liquid bottle 32. The bottom of the base 34 is provided with a horizontal sliding mechanism 35, which is used to drive the base 34 to slide to the bottom of the cover opening mechanism and the needling mechanism 29 respectively, so as to realize the opening of the stock liquid bottle delivery tank lid 40 and the extraction of the stock liquid in the stock liquid bottle 32 in turn; a stock liquid extraction needle 31 is fixed on the needling mechanism 29, which is used to extract the stock liquid in the stock liquid bottle 32 and transfer it to the drug dilution bottle 26 through the drug liquid subpackaging transfer catheter 15.

[0059] Please refer to the attached Figure 3 As shown, the lower shell 2 is further provided with a hanging hole for hanging a syringe 41 for flushing a liquid medicine. The syringe 41 for flushing a liquid medicine is used to fill a flushing liquid and air. The outlet end of the syringe 41 for flushing a liquid medicine is connected to the gas-liquid introduction needle 30 through a catheter. The gas-liquid introduction needle 30 is inserted into the stock liquid bottle 32 through the acupuncture mechanism 29. When the diaphragm pump 37 is started to extract the stock liquid in the stock liquid bottle 32, the flushing liquid and air in the syringe 41 for flushing a liquid medicine are sucked into the stock liquid bottle 32 in turn by the negative pressure, thereby realizing the extraction of the stock liquid in the stock liquid bottle 32 and the flushing of the stock liquid bottle 32 at one time. As shown in the attached figure Figure 7 shown.

[0060] Refer to the attached Figure 10 As shown, the medicine bottle protective cover 25 in this embodiment is surrounded by a top lead cover 22, a bottom lead seat 251 and four side lead blocks 252, and the thickness of the lead blocks is 60 mm. An activity detector 42 for detecting the activity of the medicine liquid in the medicine dilution bottle 26 is provided on the inner wall of the side lead block 252, and a first avoidance hole 253 for the conduit passing through the medicine bottle protective cover 25 is provided on the side lead block 252 near the middle of the upper shell 1. The top lead cover 22 is opened and closed by a push-pull method, and a locking pin 24, such as an elastic locking pin, is provided on the upper shell 1 for controlling the opening and closing sliding of the top lead cover 22. As shown in the attached Figure 11 and 12 As shown, when the medicine bottle protective cover 25 needs to be opened, it is only necessary to pull out the locking pin 24 and the top lead cover 22 can be easily pulled by the handle 221, which overcomes the disadvantage that the existing top lead cover needs to be lifted, and because the top lead cover is very heavy, it is easy to hit the upper shell when buckled, causing damage to the upper shell or a safety hazard.

[0061] In addition, a second avoidance hole is provided on the side lead block 252 near the outside of the upper shell 1 for the catheter connected to the stock solution extraction needle 31 to pass through, and a hose protective cover 28 is also provided on the outside of the upper shell 1. Figure 1 and 4 As shown, it is used to protect the catheter connected to the raw liquid extraction needle 31 before entering the second avoidance hole. The hose protective cover 28 can be rotated to open, which is convenient for the installation of the catheter.

[0062] In this embodiment, the independent three-way valve 43 can be omitted, and the water bottle extraction tube 27 can be directly connected to one port of the three three-way valves connected in series, thereby still achieving water extraction from the water bottle. The independent three-way valve 43 is easily disassembled because it is separately provided, which facilitates the structural arrangement for existing small space packaging scenarios, and has flexible configuration and wide adaptability.

[0063] Refer to the attached Figure 13 and 14As shown, the cup holder mechanism 12 in this embodiment includes a cup holder 121 for placing the liquid medicine receiving cup 13, a hose holder 122 for mounting the liquid medicine discharge pipe 14, a three-link mechanism, and a power mechanism for driving the extension and retraction of the cup holder 121. This power mechanism can employ a rack and pinion transmission mechanism to drive the extension and retraction of the cup holder 121. The central portion of the hose holder 122 is pivotally fixed to a vertical plate 123 located within the upper housing 1 via a pin, and the outer end of the hose holder 122 is configured in an L-shaped structure. The three-link mechanism includes a horizontal push block 124, a triangular block 125, and a vertical rod 126. One end of the horizontal push block 124 abuts the inner side of the cup holder 121, and the other end is hinged to the first corner of the triangular block 125. The second corner of the triangular block 125 is rotatably connected to the vertical plate 123. The third triangular end of the triangular block 125 is hinged to the bottom end of the vertical rod 126. The top end of the vertical rod 126 is hinged to the inner end of the hose rack 122. A return spring 127 is also connected to the inner end of the hose rack 122, and the other end of the return spring 127 is connected to the bottom of the vertical plate 123. When the cup holder 121 moves inward under the action of the power mechanism, it drives the horizontal push block 124 inward, pushing the triangular block 125 to rotate, which in turn pushes the vertical rod 126 upward, causing the inner end of the hose rack 122 to rotate upward, and then the outer end of the hose rack 122 to rotate downward, driving the outlet end of the liquid medicine discharge pipe 14 close to the inner wall of the liquid medicine receiving cup 13 to prevent splashing of the liquid medicine during discharge. When the cup holder 121 extends outward under the action of the power mechanism, the return spring 127 rebounds to cause the inner end of the hose holder 122 to rotate downward, thereby causing the outer end of the hose holder 122 to rotate upward to above the liquid medicine receiving cup 13, so that its L-shaped end does not affect the liquid medicine receiving cup 13 from extending outward with the cup holder 121.

[0064] For example, Figure 1 As shown, the upper shell 1 is provided with an automatic opening and closing door 11 corresponding to the cup holder mechanism 12. The power mechanism drives the cup holder 121 and the medicine receiving cup 13 to extend from the outer shell 1 from the opening of the automatic opening and closing door 11 for direct use by the patient.

[0065] Refer to the attached Figure 15 and 16As shown, the cover opening mechanism 39 includes a first sliding shaft 391 fixed to the interior of the lower housing 2, a sliding base plate 392 that slides up and down along the first sliding shaft 391, a cover opening operating handle 393 connected to the edge of the sliding base plate 392, and an opening and closing unit provided on the sliding base plate 392. The cover opening operating handle 393 extends out of a first vertical sliding groove on the lower housing 2, and a cover opening locking member 394 is provided at the upper end of the first vertical sliding groove for locking the cover opening operating handle 393. The cover opening locking member 394 can adopt any existing locking structure.

[0066] The opening and closing unit includes an opening and closing operating rod 395, an opening and closing slider 396, an opening and closing connecting rod 397 and an opening and closing hook 398. Two pins are provided in the middle of the opening and closing operating rod 395. The first pin is rotatably connected to the sliding base plate 392, and the second pin is set in the central long hole of the opening and closing slider 396. The upper part of the opening and closing slider 396 is connected to the upper part of the sliding base plate 392 through a first spring 399. The two sides of the lower part of the opening and closing slider 396 are respectively connected to an opening and closing connecting rod 397, and the lower end of the opening and closing connecting rod 397 is respectively connected to an opening and closing hook Hook 398, the lower end of the opening and closing hook 398 is provided with a barb 3981, and the upper end is provided with two connection points, the outer connection point is hinged to the lower end of the opening and closing link 397, and the inner connection point is hinged to the sliding base 392. The two opening and closing hooks 398 are arranged opposite each other. Under the elastic force of the first spring 399, the opening and closing slider 396 pushes the barbs 3981 at the lower ends of the two opening and closing hooks 398 to tighten, thereby grasping the tank cover 40 of the raw liquid bottle delivery tank 33. Lifting the lid opening handle 393 upward can lift and clamp the tank cover 40. When the opening and closing operating lever 395 drives the opening and closing slider 396 upward under the action of external force, the two opening and closing links 397 drive the lower end barbs of the two opening and closing hooks 398 to expand, thereby releasing the tank cover 40.

[0067] The opening and closing unit also includes a locking unit, which includes a locking plate 400 fixed on the upper part of the first sliding shaft 391, and a locking block 3951 fixed on the inner end of the opening and closing operating rod 395. A locking space is formed between the bottom of the locking plate 400 and the first sliding shaft 391. When the opening and closing operating rod 395 is not subjected to external force, the locking block 3951 can enter the locking space with the sliding base plate 391, that is, the locking plate 400 is tightly fitted with the locking block 3951, preventing the locking block 3951 from rotating, and then preventing the opening and closing operating rod 395 from rotating, thereby locking the opening and closing operating rod 395 to prevent the tank cover 40 from falling.

[0068] The lid opening mechanism 39 also includes a lid opening limit unit, which includes a lid opening limit rod 3921 fixed to the bottom of the sliding base plate 392, and a limit hole 341 arranged on the base 34. When the lid opening limit rod 3921 moves downward with the sliding base plate 392, it can be inserted into the limit hole 341 to ensure that the lid opening mechanism 39 can achieve the opening positioning of the tank cover 40 and the locking of the lid opening position.

[0069] The outer end of each lid opening handle 393 is provided with a telescopic handle sleeve 3931. The telescopic handle sleeve 3931 is retracted in its natural state and cooperates with the lid opening locking member 394 to secure the lid opening handle 393. When the telescopic handle sleeve 3931 is pulled out under the action of an external force, it can be separated from the lid opening locking member 394, driving the lid opening handle 393 to slide up and down. The telescopic handle sleeve 3931 can adopt an existing elastic telescopic structure and can be kept retracted in its natural state.

[0070] A horizontal sliding mechanism 35 is provided at the bottom of the base 34 for moving the base 34 from the cover opening position of the cover opening mechanism 39 to the acupuncture position directly below the acupuncture mechanism 29 .

[0071] In addition, in this embodiment, a horizontal sliding mechanism 36 is further provided at the bottom of the horizontal sliding mechanism 35. The sliding direction of the horizontal sliding mechanism 36 is perpendicular to the sliding direction of the horizontal sliding mechanism 35, and is used to drive the base 34 to extend out of the lower shell 2 to facilitate the installation of the raw liquid bottle delivery tank 33.

[0072] Refer to the attached Figure 17 and 18 As shown, the acupuncture mechanism 29 includes a second sliding shaft 291 fixed to the interior of the lower housing 2, a puncture operating handle 292 that slides up and down along the second sliding shaft 291, and a needle holder base plate 293. A second spring 294 is also sleeved on the second sliding shaft 291. The upper end of the second spring 294 is connected to the puncture operating handle 292, and the lower end of the second spring 294 is connected to the needle holder base plate 293. The puncture operating handle 292 extends through a second vertical slot in the lower housing 1. The upper end of the second vertical slot is provided with a puncture locking member 295 for locking the puncture operating handle 292. The puncture locking member 295 can adopt any existing locking structure. The needle holder base plate 293 is used to secure the stock solution extraction needle 31 and the gas-liquid introduction needle 30. The needle tips of the stock solution extraction needle 31 and the gas-liquid introduction needle 30 are both positioned vertically downward to puncture the soft stopper of the stock solution bottle 32.

[0073] The acupuncture mechanism 29 also includes a acupuncture limiting unit, which includes a acupuncture limiting rod 296 fixed on the needle holder base plate 293. When the acupuncture limiting rod 296 moves downward with the needle holder base plate 293, it can be inserted into the limiting hole 341 on the base 34 to ensure that the acupuncture mechanism 29 can achieve acupuncture positioning of the raw liquid bottle 32 and lock the acupuncture position.

[0074] That is, when the puncture mechanism 29 is at its lowest position, the bottom end of the puncture limiting rod 296 just touches the upper surface of the base 34, and the needle tip of the stock solution extraction needle 31 just touches the bottom of the stock solution bottle 32. The second spring 294 can act as a buffer to prevent the needle tip from damaging the stock solution bottle 32.

[0075] The outer end of each acupuncture operating handle 292 is provided with a telescopic handle sleeve 2921. The telescopic handle sleeve 2921 is retracted in a natural state and cooperates with the acupuncture locking member 295 to secure the acupuncture operating handle 292. When the telescopic handle sleeve 2921 is pulled out under the action of an external force, it can be separated from the acupuncture locking member 295, driving the acupuncture operating handle 292 to slide up and down. The telescopic handle sleeve 2921 can adopt an existing elastic telescopic structure and can remain in a retracted state in a natural state.

[0076] The radiopharmaceutical packaging equipment mentioned above includes the following steps when implementing radiopharmaceutical packaging:

[0077] (1) Install the stock solution bottle delivery tank 33, the liquid flushing syringe 41, the stock solution extraction needle 31, the gas-liquid introduction needle 30, the liquid dilution bottle 26, the diluent extraction needle 21, the ventilation needle 23, the liquid sub-packaging transfer catheter 15 and the syringe 16, the independent three-way valve 43, the drinking water bottle and the liquid receiving cup 13, and complete the connection of the corresponding catheters;

[0078] (2) The lid 40 of the liquid dispensing tank 33 is opened by the lid opening mechanism 39, and the opened liquid dispensing tank 33 is moved to the bottom of the puncture mechanism 29 by the horizontal sliding mechanism 35, and the puncture mechanism 29 punctures the liquid dispensing tank 32;

[0079] (3) Start the diaphragm pump 37 and the electromagnetic valve 38, and transfer the stock solution in the stock solution bottle 32 and the cleaning solution in the liquid flushing syringe 41 to the liquid dilution bottle 26 at one time through the negative pressure generated by the diaphragm pump 37. Figure 7 As shown, after the transfer is completed, the diaphragm pump 37 and the solenoid valve 38 are closed;

[0080] (4) Based on the patient's demand for liquid medicine and the activity value of the liquid medicine in the liquid medicine dilution bottle 26, the liquid medicine in the liquid medicine dilution bottle 26 is extracted by the syringe 16 connected to the liquid medicine dispensing transfer catheter 15, as shown in the attached Figure 8 As shown, the extracted liquid medicine is discharged into the liquid medicine receiving cup 13 through the liquid medicine discharge pipe 14;

[0081] (5) Then, the drinking water in the drinking water bottle is extracted through the syringe 16 connected to the liquid medicine dispensing transfer catheter 15, as shown in the attached Figure 9 As shown, the extracted drinking water is discharged into the liquid medicine receiving cup 13 through the liquid medicine discharge pipe 14;

[0082] (6) Open the door 11 of the upper shell 1, and the cup holder mechanism 12 sends the liquid medicine receiving cup 13 out of the upper shell 1, completing the liquid medicine packaging for the patient to drink.

[0083] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Those skilled in the art can make some simple modifications, equivalent changes or modifications based on the technical content disclosed above, which all fall within the scope of protection of the present invention.

Claims

1. A radiopharmaceutical dispensing device, comprising an upper shell, wherein the upper shell is provided with a medicine bottle protective cover for placing a medicine liquid dilution bottle, a dispensing protective cover for installing a medicine liquid dispensing transfer tube, a cup holder mechanism for placing a medicine liquid receiving cup, and a driving mechanism for driving a syringe connected to the medicine liquid dispensing transfer tube to be inserted, pulled out and moved, and the medicine liquid dispensing transfer tube includes at least three three-way valves connected in series, the ends of the three-way valves being respectively connected to a syringe, a diluent extraction needle, a stock solution extraction needle, a drinking water extraction tube and a medicine liquid discharge tube, characterized in that: It also includes a lower shell body located below the upper shell body, and the bottom of the lower shell body is provided with a base for placing the stock liquid bottle delivery tank, and the top of the base is provided with a cover opening mechanism for opening the lid of the stock liquid bottle delivery tank and a needling mechanism for extracting the stock liquid in the stock liquid bottle. The bottom of the base is provided with a horizontal sliding mechanism for driving the base to slide to the bottom of the cover opening mechanism and the needling mechanism respectively, so as to realize the opening of the lid of the stock liquid bottle delivery tank and the extraction of the stock liquid in the stock liquid bottle in turn; a stock liquid extraction needle is fixed on the needling mechanism, which is used to extract the stock liquid in the stock liquid bottle and transfer it to the drug dilution bottle through the drug liquid subpackaging transfer catheter.

2. The radiopharmaceutical packaging equipment according to claim 1, characterized in that: The upper shell also includes a diaphragm pump, a solenoid valve and a ventilation needle. The air inlet end of the diaphragm pump is connected to the first port of the solenoid valve, the second port of the solenoid valve is connected to the ventilation needle, and the third port of the solenoid valve is connected to the internal space of the upper shell. When the solenoid valve is energized, its first port is communicated with the second port. When the diaphragm pump is started, a negative pressure is formed inside the medicine dilution bottle, and the original liquid in the original liquid bottle enters the medicine dilution bottle under the action of the negative pressure; when the solenoid valve loses power, its third port is communicated with the second port, thereby realizing the communication between the medicine dilution bottle and the internal space of the upper shell, which is convenient for the syringe connected to the medicine liquid filling transfer catheter to extract the medicine from the medicine dilution bottle.

3. The radiopharmaceutical packaging equipment according to claim 2, characterized in that: The packaging equipment is also provided with a hanging hole for hanging a syringe for flushing the liquid medicine. The syringe for flushing the liquid medicine is used to be filled with flushing liquid and air. The outlet end of the syringe for flushing the liquid medicine is connected to a gas-liquid introduction needle through a catheter. The gas-liquid introduction needle is inserted into the stock liquid bottle through the acupuncture mechanism. When the diaphragm pump is started to extract the stock liquid in the stock liquid bottle, the flushing liquid and air in the syringe for flushing the liquid medicine are sucked into the stock liquid bottle in turn by the negative pressure, thereby realizing the extraction of the stock liquid in the stock liquid bottle and the flushing of the stock liquid bottle at one time.

4. The radiopharmaceutical packaging equipment according to claim 1, characterized in that: The medicine bottle protective cover is composed of a top lead cover, a bottom lead seat and four side lead blocks. An activity detector for detecting the activity of the medicine dilution bottle is provided on the inner wall of the side lead block. A first avoidance hole for the conduit passing through the medicine bottle protective cover is provided on the side lead block near the middle of the upper shell. The top lead cover is opened and closed in a push-pull manner, and a locking pin for controlling the opening and closing sliding of the top lead cover is provided on the upper shell.

5. The radiopharmaceutical packaging equipment according to claim 4, characterized in that: A second avoidance hole is provided on the side lead block near the outside of the upper shell for the catheter connected to the raw liquid extraction needle to pass through. A hose protective cover is also provided on the outside of the upper shell for protecting the catheter connected to the raw liquid extraction needle before it enters the second avoidance hole.

6. The radiopharmaceutical packaging equipment according to claim 1, characterized in that: The cup holder mechanism includes a cup holder for placing a medicine liquid receiving cup, a hose holder and a three-link rod for installing a medicine liquid discharge pipe, as well as a power mechanism for driving the cup holder to telescope and move. The middle part of the hose holder is rotatably fixed to the vertical plate located in the upper shell by a pin shaft, and the outer end of the hose holder is arranged into an L-shaped structure. The three-link rod includes a horizontal push block, a triangular block and a vertical rod. The outer end of the horizontal push block is abutted against the inner side of the cup holder, and the other end is hinged to the first corner end of the triangular block. The second corner end of the triangular block is rotatably connected to the vertical plate, the third triangular end of the triangular block is hinged to the bottom end of the vertical rod, the top end of the vertical rod is hinged to the inner end of the hose holder, and the inner end of the hose holder is also connected to a return The cam is pressed against the bottom of the cup holder and the cup holder is pressed against the bottom of the cup holder, and the cam is pressed against the bottom of the cup holder, so that the cup holder is pressed against the bottom of the cup holder and the cup holder is pressed against the bottom of the cup holder. The cam is pressed against the bottom of the cup holder and the cup holder is pressed against the bottom of the cup holder. The cam is pressed against the bottom of the cup holder and the cup holder is pressed against the bottom of the cup holder.

7. The radiopharmaceutical packaging equipment according to any one of claims 1 to 6, characterized in that: The cover opening mechanism includes a first sliding shaft fixed to the interior of the lower housing, a sliding base that slides up and down along the first sliding shaft, a cover opening operating handle connected to the edge of the sliding base, and an opening and closing unit provided on the sliding base; the cover opening operating handle extends out of a first vertical sliding groove on the lower housing, and an open cover locking member is provided at the upper end of the first vertical sliding groove for locking the cover opening operating handle; The opening and closing unit includes an opening and closing operating lever, an opening and closing slider, an opening and closing connecting rod and an opening and closing hook. Two pins are provided in the middle of the opening and closing operating lever, the first pin is rotatably connected to the sliding base, and the second pin is arranged in the central long hole of the opening and closing slider. The upper part of the opening and closing slider is connected to the upper part of the sliding base through a first spring, and the two sides of the lower part of the opening and closing slider are respectively connected to an opening and closing connecting rod, and the lower end of the opening and closing connecting rod is respectively connected to an opening and closing hook, and the lower end of the opening and closing hook is provided with a barb, and the upper end thereof is provided with two The outer connection point is hinged to the lower end of the opening and closing link, and the inner connection point is hinged to the sliding base. The two opening and closing hooks are arranged opposite to each other. Under the elastic force of the first spring, the opening and closing slider pushes the two lower end hooks of the opening and closing hooks to tighten, so as to grasp the tank cover of the raw liquid bottle delivery tank, lift it and clamp it, and when the opening and closing operating lever drives the opening and closing slider to move upward under the action of external force, the two opening and closing connecting rods drive the lower end hooks of the two opening and closing hooks to expand, thereby releasing the tank cover.

8. The radiopharmaceutical packaging equipment according to claim 7, characterized in that: The opening and closing unit further includes a locking unit, which includes a locking plate fixed to the upper portion of the first sliding shaft, and a locking block fixed to the inner end of the opening and closing operating rod, wherein a locking space is formed between the bottom of the locking plate and the first sliding shaft, and when the opening and closing operating rod is not subjected to an external force, the locking block can enter the locking space along with the sliding base plate to lock the opening and closing operating rod; The lid opening mechanism also includes a lid opening limiting unit, which includes a lid opening limiting rod fixed to the bottom of the sliding base and a limiting hole provided on the base. When the lid opening limiting rod moves downward with the sliding base, it can be inserted into the limiting hole to ensure that the lid opening mechanism can position the can lid for opening and lock the lid opening position.

9. The radiopharmaceutical packaging equipment according to claim 8, characterized in that: The acupuncture mechanism includes a second sliding shaft fixed to the interior of the lower housing, an acupuncture operating handle sliding up and down along the second sliding shaft, and a needle holder base plate, the second sliding shaft is further sleeved with a second spring, the upper end of the second spring is connected to the acupuncture operating handle, and the lower end of the second spring is connected to the needle holder base plate, the acupuncture operating handle extends out of the second vertical slide groove on the lower housing, and the upper end of the second vertical slide groove is provided with an acupuncture locking member for locking the acupuncture operating handle; the needle holder base plate is used to fix the stock liquid extraction needle and the gas-liquid introduction needle, and the needle tips of the stock liquid extraction needle and the gas-liquid introduction needle are both arranged vertically downward; The acupuncture mechanism further includes a acupuncture limiting unit, which includes a acupuncture limiting rod fixed to the needle holder base plate. When the acupuncture limiting rod moves downward with the needle holder base plate, it can be inserted into the limiting hole on the base to ensure that the acupuncture mechanism can achieve acupuncture positioning of the stock solution bottle and lock the acupuncture position. When the acupuncture mechanism is located at the bottom, the bottom end of the acupuncture limiting rod just touches the upper surface of the base, and at this time, the needle tip of the stock solution extraction needle just touches the bottom of the stock solution bottle.

10. A method for packaging radioactive drugs, characterized in that: The packaging method uses the radiopharmaceutical packaging equipment according to claim 3, comprising the following steps: (1) Install the stock solution bottle delivery tank, the syringe for flushing the liquid, the stock solution extraction needle, the gas-liquid introduction needle, the liquid dilution bottle, the diluent extraction needle, the ventilation needle, the liquid sub-packaging transfer catheter and syringe, the drinking water bottle and the liquid receiving cup, and complete the corresponding catheter connections; (2) The lid of the liquid dispensing bottle is opened by the lid opening mechanism, and the opened liquid dispensing bottle is moved to the bottom of the puncture mechanism by the horizontal sliding mechanism, and the liquid dispensing bottle is punctured by the puncture mechanism; (3) Start the diaphragm pump and the solenoid valve, and transfer the stock solution in the stock solution bottle and the cleaning solution in the syringe for flushing the drug solution into the drug solution dilution bottle at one time through the negative pressure generated by the diaphragm pump. After the transfer is completed, close the diaphragm pump and the solenoid valve; (4) Based on the patient's demand for liquid medicine and the activity value of the liquid medicine in the liquid medicine dilution bottle, the liquid medicine in the liquid medicine dilution bottle is extracted by a syringe connected to the liquid medicine dispensing transfer catheter, and the extracted liquid medicine is discharged into the liquid medicine receiving cup through the liquid medicine discharge tube; (5) Then, the drinking water in the drinking water bottle is extracted through a syringe connected to the liquid medicine dispensing transfer catheter, and the extracted drinking water is discharged into the liquid medicine receiving cup through the liquid medicine discharge pipe; (6) Open the door of the upper shell, and the cup holder mechanism sends the medicine liquid receiving cup out of the upper shell, completing the medicine liquid packaging for the patient to drink.

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