Medical degumming wet tissue and preparation method thereof

Abstract

The invention discloses a medical degumming wet tissue and a preparation method thereof, and relates to the technical field of degumming. According to the technical scheme, the adhesive-removing wet tissue comprises adhesive-removing wet tissue liquid and an adhesive-removing wet tissue carrier, wherein the adhesive-removing wet tissue liquid is prepared from the following components in percentage by mass: 20 to 50 percent of terpene compound, 5 to 15 percent of amide compound, 5 to 15 percent of carbonate compound, 0.1 to 10 percent of surfactant, 0.5 to 5 percent of skin care agent and 10 to 60 percent of solvent. The medical adhesive removing wet tissue can remove adhesive stains left on the surfaces of instruments, workbenches, equipment and the like of adhesive products such as medical packaging adhesive tapes and labels, and is excellent in adhesive removing effect, convenient to use, safe, environmentally friendly and free of irritation to skin.

Description

Technical Field

[0001] The present invention relates to the technical field of glue removal, in particular to a medical glue removal wet wipe and a preparation method thereof. Background Art

[0002] With the implementation of the integrated supply concept within hospital sterilization supply centers, the cleaning quality of surgical instruments is receiving increasing attention. High-quality cleaning of surgical instruments is a prerequisite for successful instrument sterilization. In clinical hospital use, common contaminants such as blood and body fluids on the surfaces of surgical instruments can be cleaned with multi-enzyme cleaners. However, multi-enzyme cleaners are unable to remove adhesive stains left on instrument surfaces and work surfaces by adhesive products such as medical labels and tapes. Failure to thoroughly remove adhesive stains from surgical instruments can easily lead to hospital-acquired infections and spark conflicts between doctors and patients.

[0003] Traditional adhesive removers are mostly organic solvents, such as acetone and xylene. These organic solvents have strong dissolving power and can quickly break down adhesive stains, but they also have high toxicity and volatility. Chinese invention patent CN114774217B discloses a low-solubility, high-adhesion adhesive remover, its preparation method, and applications. However, the main solvent in this adhesive remover is a benzene-based solvent, such as benzene, toluene, xylene, and trimethylbenzene, which are highly harmful to humans and the environment.

[0004] Chinese invention patent CN110791389B discloses a glue remover, its preparation method, and its application. However, after spraying and dissolving the glue stains with the remover, the glue stains must be removed with a cotton cloth, scraper, or other tool, making the process cumbersome and inconvenient. Surface hygiene wipes and disinfectant wipes commonly used in hospitals primarily clean and disinfect, but have limited ability to remove glue stains. While they are effective at removing dirt and bacteria from surfaces, they often struggle to achieve the desired cleaning effect when it comes to glue stains.

[0005] Based on the above situation, it is of great significance to develop a medical adhesive removal wipe for surgical instruments that has good adhesive removal effect and is easy to use, safe, environmentally friendly, and non-irritating to the skin. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to overcome the shortcomings of the existing technology and provide a medical adhesive removal wipe and a preparation method thereof, which can remove adhesive stains left by adhesive products such as medical packaging tapes and labels on the surface of instruments, work surfaces, equipment surfaces, etc., and has excellent adhesive removal effect, is easy to use, safe and environmentally friendly, and has no irritation to the skin.

[0007] The technical solution of the present invention is: On the one hand, the present invention provides a medical adhesive removing wipe, comprising an adhesive removing wipe liquid and an adhesive removing wipe carrier, wherein the adhesive removing wipe liquid is composed of the following components in the following mass percentages: 20-50% terpene compounds, 5-15% amide compounds, 5-15% carbonate compounds, 0.1-10% surfactants, 0.5-5% skin care agents, and 10-60% solvents.

[0008] Preferably, the terpene compound is one or more of D-limonene, sweet orange oil, tangerine oil and terpinene.

[0009] Preferably, the amide compound is one or more of formamide, N,N-dimethylformamide and N,N-dimethylacetamide.

[0010] Preferably, the carbonate compound is one or more of dimethyl carbonate, diethyl carbonate, ethyl methyl carbonate, propylene carbonate and ethylene carbonate.

[0011] Preferably, the surfactant is one or more of sophorolipids, rhamnolipids, sodium cocoyl glycinate, sodium cocoyl glutamate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate and sodium cocoylaminopropionate.

[0012] Preferably, the skin care agent is one or more of hyaluronic acid, squalane, ceramide, asiaticoside, resveratrol and D-panthenol.

[0013] Preferably, the solvent is one or more of ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, tert-butanol, isobutanol, ethylene glycol, 1,2-propylene glycol and 1,3-propylene glycol.

[0014] Preferably, the adhesive removal wipe carrier is a spunlace non-woven fabric with a gram weight of 40-80g / m 2 .

[0015] Preferably, the mass ratio of the adhesive removal wipes liquid to the adhesive removal wipes carrier is (2-5):1.

[0016] On the other hand, the present invention provides a method for preparing the above-mentioned medical adhesive removal wipes, comprising the following steps: S1. Add the solvent, amide compound, carbonate compound and terpene compound to the preparation tank in sequence and stir to mix evenly; Add surfactant to S2 and stir until completely dissolved; S3 adds skin care agent and stirs to mix well to prepare glue removal wipes liquid; S4 sprays the adhesive removal wipes liquid evenly on the adhesive removal wipes carrier; S5 cuts the adhesive removal wet wipe carrier into individual pieces, folds them according to the packaging method, and heat-seals them in a packaging bag to obtain the medical adhesive removal wet wipes.

[0017] Compared with the prior art, the present invention has the following beneficial effects: 1. The glue removal effect of the medical glue removal wipes of the present invention is mainly based on the chemical principle of "like dissolves like". The "like dissolves like" principle means that polar molecules are easily soluble in polar solvents, and non-polar molecules are easily soluble in non-polar solvents. When the intermolecular forces of the solute and the solvent are similar, they can better mix and dissolve with each other. The terpene compounds adopted in the present invention are natural extracts. They can soften and decompose stubborn stains and remove various types of glue stains in a targeted manner through dissolution. This type of compound not only has a good glue removal effect, but also has the fresh smell of citrus fruits. When removing glue stains, it will not leave an uncomfortable taste and has the characteristics of being natural, gentle and non-irritating. The chemical structure of the amide compounds and carbonate compounds adopted in the present invention is similar to the chemical structure of glue stains. Therefore, amide compounds, carbonate compounds and terpene compounds can better play a role in synergistically dissolving glue stains. The surfactants used in the present invention are natural surfactants and amino acid surfactants. These surfactants can better reduce surface tension, allow other components to more fully contact the glue stains, and enhance the emulsification and dispersion of the glue stains. They have the characteristics of mild performance, good biodegradability, safety and environmental protection. The skin care agent used in the present invention uses natural extracts as the main active ingredients. After mixing these natural extracts with other components, they can not only play a synergistic effect in removing glue stains, but also effectively maintain skin moisture, prevent skin from drying out, and play a nursing role on the skin while removing glue. The medical glue-removing wipes of the present invention can remove glue stains left by adhesive products such as medical packaging tapes and labels on the surface of instruments, work surfaces, equipment surfaces, etc., and have excellent glue removal effect, are easy to use, safe and environmentally friendly, and have no irritation to the skin.

[0018] 2. The medical adhesive-removing wipes of the present invention are individually packaged. During use, you only need to hold the adhesive-removing wipes and wipe them gently to dissolve and remove the adhesive stains using the adhesive-removing ingredients in the wipes. No additional wiping tools or complicated operating procedures are required, thereby improving the work efficiency of medical staff. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a photo of residual glue stains left on the surface of the curved plate when preparing standard pollutants according to the present invention.

[0020] Figure 2 This is a photograph of the medical adhesive removal wipes according to Example 1 of the present invention after removing adhesive from standard adhesive stains. DETAILED DESCRIPTION

[0021] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention.

[0022] Example 1 The medical adhesive removal wipes of this embodiment include adhesive removal wipes liquid and adhesive removal wipes carrier in a mass ratio of 3:1. The adhesive removal wipes carrier adopts a gram weight of 60g / m 2 The spunlace non-woven fabric is made of the following components in percentage by weight: 35% D-limonene, 10% N,N-dimethylformamide, 10% dimethyl carbonate, 6% sophorolipids, 4% squalane, and 35% ethanol.

[0023] The preparation method of the medical adhesive removal wipes of this embodiment comprises the following steps: S1. Add ethanol, N,N-dimethylformamide, dimethyl carbonate, and D-limonene to the preparation tank in sequence and stir to mix evenly; S2 adds sophorolipid and stirs until completely dissolved; Add squalane to S3 and stir to mix well to prepare a liquid adhesive removal wipe. S4 sprays the adhesive removal wipes liquid evenly on the adhesive removal wipes carrier; S5 cuts the adhesive removal wet wipe carrier into individual pieces, folds them according to the packaging method, and heat-seals them in a packaging bag to obtain the medical adhesive removal wet wipes.

[0024] Example 2 The medical adhesive removal wipes of this embodiment include adhesive removal wipes liquid and adhesive removal wipes carrier in a mass ratio of 5:1. The adhesive removal wipes carrier adopts a 40g / m 2 The spunlace non-woven fabric is made of the following components in percentage by weight: 50% sweet orange oil, 5% N,N-dimethylacetamide, 5% ethyl methyl carbonate, 10% rhamnolipid, 2% resveratrol, and 28% isopropyl alcohol.

[0025] The preparation method of the medical adhesive removal wipes of this embodiment comprises the following steps: S1. Add isopropyl alcohol, N,N-dimethylacetamide, ethyl methyl carbonate, and sweet orange oil to the preparation tank in sequence and stir to mix evenly; S2 adds rhamnolipid and stirs until completely dissolved; S3 adds resveratrol and stirs to mix well to prepare a glue removing wipe liquid; S4 sprays the adhesive removal wipes liquid evenly on the adhesive removal wipes carrier; S5 cuts the adhesive removal wet wipe carrier into individual pieces, folds them according to the packaging method, and heat-seals them in a packaging bag to obtain the medical adhesive removal wet wipes.

[0026] Example 3 The medical adhesive removal wipes of this embodiment include adhesive removal wipes liquid and adhesive removal wipes carrier in a mass ratio of 2:1. The adhesive removal wipes carrier adopts a gram weight of 80g / m 2 The spunlace non-woven fabric is made of the following components in percentage by weight: 20% terpinene, 10% orange oil, 2% formamide, 11% N,N-dimethylformamide, 15% ethylene carbonate, 1% sodium cocoamidopropionate, 5% hyaluronic acid, and 36% 1,2-propylene glycol.

[0027] The preparation method of the medical adhesive removal wipes of this embodiment comprises the following steps: S1: Add 1,2-propylene glycol, formamide, N,N-dimethylformamide, ethylene carbonate, terpinene, and orange oil to the preparation tank in sequence and stir to mix evenly; S2 adds sodium cocoamidopropionate and stirs until completely dissolved; Add hyaluronic acid to S3 and stir to mix well to prepare a glue removing wipe liquid; S4 sprays the adhesive removal wipes liquid evenly on the adhesive removal wipes carrier; S5 cuts the adhesive removal wet wipe carrier into individual pieces, folds them according to the packaging method, and heat-seals them in a packaging bag to obtain the medical adhesive removal wet wipes.

[0028] Comparative Example 1 The medical adhesive removal wipes of Comparative Example 1 are surface hygiene wipes produced by Shandong Xinhua Saraya Biotechnology Co., Ltd.

[0029] Comparative Example 2 Comparative Example 2 uses a debonding agent disclosed in Chinese invention patent CN110791389B and its preparation method and application. The debonding agent prepared in Example 1 is specifically: An environmentally friendly adhesive remover, the raw materials of which include 65 parts of D-limonene, 35 parts of deodorized hydrocarbon solvent, 12 1 part penetrant, 7 parts surfactant, 10 parts dibasic acid ester, 60 parts water.

[0030] The deodorized hydrocarbon solvent is D110 solvent, which was purchased from Shanghai Huishuo Chemical Co., Ltd.

[0031] The penetrant is ethylene glycol methyl ether.

[0032] The surfactant is selected from coconut oil glycol amide.

[0033] The dibasic acid methyl ester monomer is selected from the combination of dimethyl succinate, dimethyl glutarate, and dimethyl adipate, and the ratio of dimethyl succinate, dimethyl glutarate, and dimethyl adipate is 1:0.8:0.25.

[0034] The raw materials also include a polyether derivative containing an amino group; the amount of the polyether derivative containing an amino group is 12% of the mass of the limonene, and the polyether derivative containing an amino group is 4-aminobutyraldehyde diethyl acetal and ethylene glycol di(3-aminopropyl) ether. The weight ratio of the 4-aminobutyraldehyde diethyl acetal to ethylene glycol di(3-aminopropyl) ether is 1:0.8.

[0035] The preparation method of the environmentally friendly adhesive remover comprises the following steps: (1) Add limonene, penetrant, and deodorized hydrocarbon solvent into a reactor and stir. Raise the temperature to 65°C while stirring, and then keep stirring for 45 minutes. (2) Add the remaining raw materials in sequence and continue stirring for 30 minutes; (3) After stirring, let it stand for 8.5 hours to defoam, and then filter to obtain the product.

[0036] Comparative Example 3 The difference from Example 1 is that the adhesive removal wipes liquid is composed of the following components in percentage by mass: 35% D-limonene, 6% sophorolipids, 4% squalane, and 55% ethanol.

[0037] Comparative Example 4 Comparative Example 4 uses a low-solubility, high-adhesion adhesive remover disclosed in Chinese invention patent CN114774217B, and its preparation method and application. The adhesive remover prepared in Example 1 is specifically: The adhesive remover comprises the following components:

[0038] The preparation method is as follows: According to the formula, weigh the above components and mix them evenly.

[0039] The preparation method of the glycerol gel comprises the following steps: mixing polyvinyl alcohol and glycerol in a mass ratio of 1:90 and heating them to form a viscous liquid, thereby obtaining the glycerol gel.

[0040] Comparative Example 5 The difference from Example 1 is that the adhesive removal wipes liquid is composed of the following components in percentage by mass: 35% D-limonene, 10% dimethyl carbonate, 6% sophorolipids, 4% squalane, and 45% ethanol.

[0041] Comparative Example 6 The difference from Example 1 is that the adhesive removal wipes liquid is composed of the following components in percentage by mass: 35% D-limonene, 10% N,N-dimethylformamide, 6% sophorolipids, 4% squalane, and 45% ethanol.

[0042] The medical adhesive removal wipes or adhesive removers of Examples 1-3 and Comparative Examples 1-6 were tested for adhesive removal performance. The test method is as follows: 1) Preparation of standard pollutants Paste a medical label (length × width: 60mm × 33mm) on the surface of the curved plate and place it in a 120℃ oven. After 30 minutes, take it out and quickly tear off the label paper. There will be residual glue stains on the surface of the curved plate (such as Figure 1 as shown), prepared as standard pollutants.

[0043] 2) How to remove glue stains The glue stains on the surface of the curved plate were wiped with the glue removal wipes of Examples 1-3 and Comparative Examples 1, 3, 5-6, respectively. The wiping time was 10 seconds. The removal effect of the glue stains on the surface of the curved plate was observed and the glue removal rate was calculated.

[0044] The glue removers of Comparative Examples 2 and 4 were sprayed onto the glue stains on the surface of the curved plate and completely covered, and immediately wiped with cotton cloth for 10 seconds. The removal effect of the glue stains on the curved plate surface was observed and the glue removal rate was calculated.

[0045] 3) Calculation formula for glue removal rate Glue removal rate (%) = (total glue stain area - remaining glue stain area) / total glue stain area × 100%.

[0046] The degumming effect of the prepared glue stain standard pollutants was compared using the degumming products of Examples 1-3 and Comparative Examples 1-6, and the degumming rate is shown in Table 1. The effect of the medical degumming wipes of Example 1 on the degumming of glue stain standard pollutants before and after degumming is shown in Table 1. Figure 1-2 shown.

[0047] Table 1 Glue removal rate of the degumming products of Examples 1-3 and Comparative Examples 1-6

[0048] It can be seen from Table 1 that the adhesive removal rates of the medical adhesive removal wipes prepared using Examples 1-3 are all greater than 99.9%. Figure 1-2It can be seen that the medical adhesive removal wipes prepared in Example 1 of the present invention can completely remove adhesive stains on the surface of the device, with excellent adhesive removal effect. The adhesive removal rate of the commercially available surface hygiene wipes in Comparative Example 1 is only 48.26%, and the adhesive removal effect is not ideal. The adhesive removal agent prepared in Comparative Example 2 has an adhesive removal rate of 96.68%, which is slightly worse than the medical adhesive removal wipes in Example 1, and requires additional wiping tools such as cotton cloth, which is inconvenient to use. The adhesive removal rate of the adhesive removal wipes prepared in Comparative Example 3 is 82.35%, which is significantly lower than that of Example 1. This is because the addition of amide compounds and carbonate compounds can synergistically remove adhesive stains with terpenes. The adhesive removal rate of the adhesive removal agent prepared in Comparative Example 4 is 95.78%, and the adhesive removal effect is slightly worse than that of the medical adhesive removal wipes in Example 1. On the one hand, Comparative Example 4 requires additional wiping tools for adhesive removal, which is inconvenient to use; on the other hand, the main solvent used in Comparative Example 4 is toluene, which is more harmful to the human body. The glue removal efficiency of the glue removal wipes prepared in Comparative Example 5 was 91.17%, and the glue removal efficiency of the glue removal wipes prepared in Comparative Example 6 was 91.09%. Compared with Example 1, the glue removal efficiency was reduced to a certain extent, but compared with Comparative Example 3, the glue removal efficiency was increased to a certain extent. This is because the addition of carbonate compounds and amide compounds can synergistically remove glue stains with terpenes.

[0049] In summary, the medical adhesive-removing wet wipes prepared by the present invention have good adhesive-removing effect and are easy to use.

[0050] A complete skin irritation test A complete skin irritation test was conducted in accordance with the Technical Specifications for Disinfection (2002 edition). The specific experimental method is as follows: 1) The test samples were the adhesive remover wipes liquid of Example 1 and the adhesive remover of Comparative Example 4.

[0051] 2) 24 hours before the experiment, remove the hair on both sides of the spine of Japanese white rabbits with a depilatory agent, covering an area of approximately 3 cm × 3 cm. Each group includes three female white rabbits weighing 2-2.5 kg.

[0052] 3) The next day, 0.5 mL of the test sample was dropped directly onto an area of 2.5 cm x 2.5 cm on the left side of the intact, hairless skin. The area was then covered with a non-irritating plastic wrap and secured with non-irritating adhesive tape. The right side served as a blank control. Four hours after application, the area was rinsed with warm water to remove any remaining test sample.

[0053] 4) Observe and score the local skin reaction 1 hour, 24 hours, and 48 hours after removing the residual test sample. The scoring criteria and irritation intensity classification refer to Tables 2-11 and 2-12 in Section 2.3.3 "Skin Irritation Test" of the "Technical Specifications for Disinfection" (2002 edition).

[0054] The scoring results of a complete skin irritation test of the adhesive removal wet wipes liquid of Example 1 are shown in Table 2: Table 2 Scoring results of a complete skin irritation test on the adhesive removal wipes liquid of Example 1

[0055] As can be seen from Table 2, 1 hour, 24 hours, and 48 hours after removing the residual adhesive removal wipes liquid of Test Example 1, no skin irritation reaction was found on the infected side and the control side of the three animals. The highest skin irritation index was 0.00, and the irritation intensity was non-irritating.

[0056] The scoring results of a complete skin irritation test of the adhesive remover prepared in Comparative Example 4 are shown in Table 3: Table 3 Scoring results of a complete skin irritation test on the adhesive removal wipes liquid of Comparative Example 4

[0057] As can be seen in Table 3, no skin irritation was observed in the control group 1, 24, and 48 hours after the residual adhesive remover from Comparative Example 4 was removed. However, erythema developed on the exposed side of rabbit No. 5 at 24 and 48 hours, and edema developed on the exposed side of rabbit No. 6 at 48 hours. The highest skin irritation index of the adhesive remover from Comparative Example 4 was 0.67, indicating a mild irritation.

[0058] In summary, the adhesive remover wipes of Example 1 of the present invention are non-irritating to the skin, while the adhesive remover of Comparative Example 4 is mildly irritating to the skin. This may be related to the skin care agent added to the present invention, which effectively retains skin moisture, prevents dryness, and provides skin care. Comparative Example 4, on the other hand, contains a benzene-based solvent. While these ingredients are more effective in removing adhesive, they are also more irritating to the skin.

Claims

1. Medical adhesive removal wipes, characterized in that: The adhesive removing wet wipes include liquid and a carrier. The liquid is composed of the following components in percentage by mass: 20-50% terpene compounds, 5-15% amide compounds, 5-15% carbonate compounds, 0.1-10% surfactants, 0.5-5% skin care agents, and 10-60% solvents.

2. The medical adhesive removal wipes according to claim 1, wherein: The terpene compound is one or more of D-limonene, sweet orange oil, tangerine oil and terpinene.

3. The medical adhesive removal wipes according to claim 1, wherein: The amide compound is one or more of formamide, N,N-dimethylformamide and N,N-dimethylacetamide.

4. The medical adhesive removal wipes according to claim 1, wherein: The carbonate compound is one or more of dimethyl carbonate, diethyl carbonate, ethyl methyl carbonate, propylene carbonate and ethylene carbonate.

5. The medical adhesive removal wipes according to claim 1, wherein: The surfactant is one or more of sophorolipids, rhamnolipids, sodium cocoyl glycinate, sodium cocoyl glutamate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate and sodium cocoylaminopropionate.

6. The medical adhesive removal wipes according to claim 1, wherein: The skin care agent is one or more of hyaluronic acid, squalane, ceramide, asiaticoside, resveratrol and D-panthenol.

7. The medical adhesive removal wipes according to claim 1, wherein: The solvent is one or more of ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, tert-butanol, isobutanol, ethylene glycol, 1,2-propylene glycol and 1,3-propylene glycol.

8. The medical adhesive removal wipes according to claim 1, wherein: The carrier of the adhesive removal wipes is a spunlace non-woven fabric, and the gram weight of the spunlace non-woven fabric is 40-80g / m 2 .

9. The medical adhesive removal wipes according to claim 1, wherein: The mass ratio of the adhesive removal wet wipes liquid to the adhesive removal wet wipes carrier is (2-5):

1.

10. The method for preparing the medical adhesive removing wipes according to any one of claims 1 to 9, wherein: The following steps are involved: S1. Add the solvent, amide compound, carbonate compound and terpene compound to the preparation tank in sequence and stir to mix evenly; Add surfactant to S2 and stir until completely dissolved; S3 adds skin care agent and stirs to mix well to prepare glue removal wipes liquid; S4 sprays the adhesive removal wipes liquid evenly on the adhesive removal wipes carrier; S5 cuts the adhesive removal wet wipe carrier into individual pieces, folds them according to the packaging method, and heat-seals them in a packaging bag to obtain the medical adhesive removal wet wipes.

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