Hydrophobic-hydrophilic interface time sequence reconfiguration hydrogel, and preparation method and application thereof
By reconstructing hydrogels through a hydrophobic-hydrophilic interface, the problems of prolonged adhesion time and reduced adhesion strength of hydrogels in the treatment of gastric ulcers are solved, achieving immediate and effective wet tissue sealing and rapid healing of gastric ulcer wounds, which is suitable for ulcer wound treatment in endoscopic procedures.
CN120514826BActive Publication Date: 2026-06-26FOURTH MILITARY MEDICAL UNIVERSITY
View PDF 2 Cites 0 Cited by
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- FOURTH MILITARY MEDICAL UNIVERSITY
- Filing Date
- 2025-04-07
- Publication Date
- 2026-06-26
Smart Images
Figure CN120514826B_ABST
Abstract
The present application belongs to the technical field of hydrogel materials, and relates to a hydrophobic-hydrophilic interface time sequence reconfiguration hydrogel, a preparation method thereof and application thereof in promoting gastric mucosa wound healing. The hydrophobic-hydrophilic interface time sequence reconfiguration hydrogel is formed by a hydrophobic matrix and bioadhesive microparticles according to a specific mass ratio, and the hydrophobic matrix is composed of a hydrophobic pH-responsive drug release porous liquid and a hydrophobic hyperbranched polyethylene oily matrix according to a mass ratio of 1:5-1:20. The hydrophobic-hydrophilic interface time sequence reconfiguration hydrogel has the advantages of instant and strong tissue sealing and acid-inhibiting wound repair, and is used for promoting gastric mucosa wound healing.
Need to check novelty before this filing date? Find Prior Art