Human body lubricating liquid and preparation method thereof

Abstract

The invention discloses a human body lubricating liquid which comprises propylene glycol, glycerol, sodium hyaluronate, carbomer, arginine, silver ions and a pH regulator, and betaine or coumarin is selectively added. Wherein the propylene glycol and the glycerol synergistically provide long-acting moisture retention, the sodium hyaluronate enhances lubrication and smoothness and repairs skin barriers, the carbomer adjusts viscosity and stability, the arginine relieves inflammation and maintains acid-base balance, the silver ions inhibit pathogenic microorganisms through broad-spectrum antibacterial characteristics, and the pH regulator enables the product to be close to the physiological pH value of a human body. Betaine and coumarin can be used in an alternative manner or have a synergistic effect, and the skin protection capability is improved by resisting inflammation and oxidation and inhibiting free radicals respectively. The human body lubricating liquid disclosed by the invention has remarkable advantages in the aspects of lubricating effect, moisturizing performance, antibacterial ability, use comfort and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of antibacterial care, in particular to a human body lubricating liquid. Background Art

[0002] As an essential component of personal care products, personal lubricants have seen rapid growth in market demand in recent years, driven by a shift in social attitudes and heightened health awareness. While traditional personal lubricant products have met this market demand to a certain extent, they still have numerous shortcomings and are in urgent need of improvement.

[0003] Current personal lubricants on the market have numerous shortcomings. Traditional lubricants lack long-lasting lubrication. Simple glycerin or propylene glycol systems struggle to maintain moistness for extended periods, and thickeners compromise the natural feel. Regarding safety, they often use synthetic ingredients, which can easily trigger allergies and damage the intimate microbiome with long-term use. They also have poor antimicrobial properties, with most relying solely on conventional preservatives. These products are susceptible to microbial contamination after opening, with approximately 30% of women experiencing vaginal flora imbalance after use. Furthermore, their ingredients lack mildness, with surfactants and preservatives potentially damaging the skin barrier and causing irritation to certain individuals. Furthermore, their pH values ​​deviate from the human physiological range (3.8-4.5), resulting in poor user comfort.

[0004] In view of these problems, the present invention aims to develop a human body lubricating fluid that is safe, comfortable, lubricating and has long-lasting antibacterial function. Summary of the Invention

[0005] The purpose of the present invention is to solve the shortcomings of the prior art and to provide a human body lubricating fluid.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] A personal lubricant comprising the following ingredients:

[0008] Propylene glycol, 5-15 wt%;

[0009] Glycerol, accounting for 10-20wt%;

[0010] Sodium hyaluronate, 0.1-0.5wt%;

[0011] Carbomer, accounting for 0.2-0.8wt%;

[0012] Arginine, 0.5-2 wt%;

[0013] Silver ions (calculated as silver compounds), accounting for 0.01-0.1wt%;

[0014] pH regulator, accounting for 0.01-0.1wt%;

[0015] Betaine, accounting for 0.5-1.5wt%

[0016] Purified water, balance.

[0017] Preferably, the betaine can be replaced by coumarin, and the content of the coumarin when replaced is 0.5-1.5 wt%.

[0018] Preferably, when betaine and coumarin are included at the same time, the contents are 0.5-1.5 wt% and 0.2-0.8 wt% respectively.

[0019] Preferably, the silver ions are derived from metabolites of specific bacterial species, and the bacterial species is selected from at least one of Lactococcus lactis, Streptococcus salivarius, and Lactobacillus reuteri.

[0020] Preferably, the lactococcus lactis is subjected to the following process to obtain a silver ion-containing functional component named LL-silver ion functional component: 25-35 g / L glucose, 10-20 g / L beef extract powder and 5-8 g / L yeast extract powder are added to MRS medium, 2-5 wt% of freeze-dried bacterial powder is inoculated, and the culture is statically cultured at 37°C±1°C for 20-30 hours until OD600 = 0.8-1.2, silver nitrate is added to a final concentration of 8-10 mg / L, and the culture is continued for 3-5 hours, followed by collecting the bacterial cells by centrifugation, soaking them in 0.1 M hydrochloric acid for 2-3 hours, and then filtering to obtain a filtrate.

[0021] Preferably, the Streptococcus salivarius obtains a silver ion-containing functional component named SS-silver ion functional component by the following process: anaerobically culturing in TPY medium at 37°C±1°C for 12-16 hours to OD600=0.8-1.0, continuing to culture with a ventilation volume of 0.8-1.2vvm and a stirring speed of 150-200rpm to OD600=1.0-1.5, adding silver nitrate at a final concentration of 6-8mg / L and 0.3-0.6% chitosan, reacting for 2-4 hours, centrifuging and taking the supernatant, and concentrating through a 10kDa ultrafiltration membrane to obtain filtrate B.

[0022] Preferably, the Lactobacillus reuteri is prepared by the following process to obtain a silver ion-containing functional ingredient named RL-silver ion functional ingredient: 2-4 g / L triammonium citrate and 2-3 g / L dipotassium hydrogen phosphate are added to a modified MRS medium, freeze-dried bacterial powder is inoculated at 3-6 wt%, and then statically cultured at 37°C±1°C for 24-36 hours, silver nitrate and 0.1-0.3% citric acid are added to a final concentration of 9-12 mg / L for 2-4 hours, and the bacteria are crushed and then centrifuged at high speed at 12000-15000 rpm×15-20 minutes to obtain a supernatant.

[0023] A method for preparing a human body lubricating fluid comprises the following steps: mixing at least one of an LL-silver ion functional component, an SS-silver ion functional component, and an RL-silver ion functional component with purified water, stirring uniformly at 50-200 r / min and 30-40° C., sequentially adding carbomer, propylene glycol, and glycerin and continuing to stir until completely dispersed, then adding sodium hyaluronate, arginine, and betaine / coumarin and stirring uniformly, and finally adding a pH regulator to adjust the pH to 4.0-5.5, stirring, cooling to room temperature, and then filling and packaging to obtain the lubricating fluid.

[0024] In this invention, propylene glycol, as a solvent and humectant, effectively prevents rapid evaporation of the lubricant during use, maintaining the product's moist state while promoting uniform dispersion of other ingredients and improving product stability. Glycerin, a highly effective moisturizing ingredient, retains skin moisture through hygroscopicity, preventing discomfort caused by dryness. It also softens the stratum corneum and improves skin flexibility. Sodium hyaluronate has excellent moisturizing properties and forms a protective film on the skin surface, enhancing the lubricant's smoothness and durability. It also promotes repair of the skin barrier and improves the self-protection of the intimate area. Carbomer, as a thickener and stabilizer, imparts the lubricant with appropriate viscosity and adhesion, improving the product's user experience and enhancing product stability by adjusting the pH value. Arginine, with its antioxidant and soothing properties, promotes skin cell metabolism, enhances skin repair capacity, alleviates discomfort caused by friction, and helps maintain the acid-base balance of the intimate area. Silver ions, with their broad-spectrum antimicrobial properties, effectively inhibit the growth and reproduction of various pathogenic microorganisms, preventing and treating gynecological diseases and urinary tract infections caused by microbial infections, and maintaining the cleanliness and hygiene of the intimate area. pH regulators are used to precisely adjust the pH of lubricants to approximate the physiological pH of the human body's intimate areas (3.8-4.5), reducing skin irritation and improving product safety and comfort. Betaine has excellent moisturizing and anti-inflammatory properties, increasing skin moisture, alleviating discomfort symptoms such as dryness and itching, and exhibiting a soothing and calming effect. Coumarin, as an alternative to betaine, possesses antioxidant and anti-inflammatory properties, protecting the skin from free radical damage, reducing inflammatory responses, and exhibiting a certain antibacterial effect. Silver ion functional components produced by the metabolism of specific bacterial species have higher activity and stability, enabling them to better exert their antibacterial effects while reducing potential irritation to the human body. Silver ion functional components in the metabolites of Lactococcus lactis have excellent antibacterial activity and stability, effectively inhibiting the growth of pathogenic microorganisms while maintaining low cytotoxicity. Silver ion functional components in the metabolites of Streptococcus salivarius have excellent sustained-release properties, enabling them to exert their antibacterial effects over an extended period of time. Silver ion functional ingredients in Lactobacillus reuteri metabolites have high biological activity and safety, effectively inhibiting the growth of harmful microorganisms while promoting the balance of beneficial bacteria. Through the scientific ratio and synergistic effect of the above ingredients.

[0025] The human body lubricating fluid of the present invention exhibits significant advantages in terms of lubricating effect, moisturizing performance, antibacterial ability and comfort of use. DETAILED DESCRIPTION

[0026] The present invention will be further explained below with reference to specific embodiments.

[0027] Example 1

[0028] The present invention provides a human body lubricant, comprising the following raw materials: 10 wt% propylene glycol, 15 wt% glycerol, 0.3 wt% sodium hyaluronate, 0.5 wt% carbomer, 1 wt% arginine, 0.05 wt% silver ions (calculated as silver compounds), 0.05 wt% pH regulator, 1 wt% betaine, and the balance being purified water. The preparation method is as follows:

[0029] S1: Mix the silver ion functional components in the metabolites of Lactococcus lactis with purified water and stir them evenly at 100 r / min and 35°C;

[0030] S2: Add carbomer, propylene glycol, and glycerin in sequence and continue stirring until completely dispersed;

[0031] S3: Add sodium hyaluronate, arginine and betaine and mix well;

[0032] S4: Finally, add a pH adjuster to adjust the pH to 4.5, stir, cool to room temperature, fill, and package to obtain the lubricating liquid.

[0033] Example 2

[0034] The present invention provides a human body lubricant, comprising: 12 wt% propylene glycol, 18 wt% glycerol, 0.4 wt% sodium hyaluronate, 0.6 wt% carbomer, 1.5 wt% arginine, 0.08 wt% silver ion (calculated as silver compound), 0.08 wt% pH adjuster, 1.2 wt% betaine, 1 wt% coumarin, and the balance purified water. The preparation method is as follows:

[0035] S1: Mix the silver ion functional components in the metabolites of Streptococcus salivarius with purified water and stir them evenly at 150 r / min and 38°C;

[0036] S2: Add carbomer, propylene glycol, and glycerin in sequence and continue stirring until completely dispersed;

[0037] S3: Add sodium hyaluronate, arginine, betaine and coumarin and mix well;

[0038] S4: Finally, add a pH adjuster to adjust the pH to 5.0, stir, cool to room temperature, fill, and package to obtain the lubricating liquid.

[0039] Example 3

[0040] The present invention provides a human body lubricant, comprising: 8 wt% propylene glycol, 12 wt% glycerol, 0.2 wt% sodium hyaluronate, 0.4 wt% carbomer, 1.2 wt% arginine, 0.03 wt% silver ion (calculated as silver compound), 0.03 wt% pH adjuster, 0.8 wt% betaine, 0.6 wt% coumarin, and the balance being purified water. The preparation method is as follows:

[0041] S1: Mix the silver ion functional components in the Lactobacillus reuteri metabolites with purified water and stir them evenly at 80 rpm and 32°C.

[0042] S2: Add carbomer, propylene glycol, and glycerin in sequence and continue stirring until completely dispersed;

[0043] S3: Add sodium hyaluronate, arginine, betaine and coumarin and mix well;

[0044] S4: Finally, add a pH adjuster to adjust the pH to 4.2, stir, cool to room temperature, fill, and package to obtain the lubricating liquid.

[0045] Example 4

[0046] The present invention provides a human body lubricant, comprising the following raw materials: 5 wt% propylene glycol, 10 wt% glycerol, 0.1 wt% sodium hyaluronate, 0.2 wt% carbomer, 0.5 wt% arginine, 0.01 wt% silver ion (calculated as silver compound), 0.01 wt% pH adjuster, 0.5 wt% betaine, and the balance being purified water. The preparation method is as follows:

[0047] S1: Mix the silver ion functional components in the metabolites of Lactococcus lactis with purified water and stir them evenly at 50 r / min and 30°C;

[0048] S2: Add carbomer, propylene glycol, and glycerin in sequence and continue stirring until completely dispersed;

[0049] S3: Add sodium hyaluronate, arginine and betaine and mix well;

[0050] S4: Finally, add a pH adjuster to adjust the pH to 4.0, stir, cool to room temperature, fill, and package to obtain the lubricating liquid.

[0051] Example 5

[0052] The present invention provides a human body lubricant, comprising the following raw materials: 15 wt% propylene glycol, 20 wt% glycerol, 0.5 wt% sodium hyaluronate, 0.8 wt% carbomer, 2 wt% arginine, 0.1 wt% silver ion (calculated as silver compound), 0.1 wt% pH adjuster, 1.5 wt% betaine, 0.8 wt% coumarin, and the balance purified water. The preparation method is as follows:

[0053] S1: Mix the silver ion functional components in the metabolites of Streptococcus salivarius with purified water and stir them evenly at 200 r / min and 40°C;

[0054] S2: Add carbomer, propylene glycol, and glycerin in sequence and continue stirring until completely dispersed;

[0055] S3: Add sodium hyaluronate, arginine, betaine and coumarin and mix well;

[0056] S4: Finally, add a pH adjuster to adjust the pH to 5.5, stir, cool to room temperature, fill, and package to obtain the lubricating liquid.

[0057] Example 6

[0058] The present invention provides a human body lubricant, comprising: 10 wt% propylene glycol, 15 wt% glycerol, 0.3 wt% sodium hyaluronate, 0.5 wt% carbomer, 1 wt% arginine, 0.05 wt% silver ion (calculated as silver compound), 0.05 wt% pH adjuster, 0.5 wt% coumarin, and the balance purified water. The preparation method is as follows:

[0059] S1: Mix the silver ion functional components in the Lactobacillus reuteri metabolites with purified water and stir them evenly at 100 r / min and 35°C;

[0060] S2: Add carbomer, propylene glycol, and glycerin in sequence and continue stirring until completely dispersed;

[0061] S3: Add sodium hyaluronate, arginine, and coumarin and mix well;

[0062] S4: Finally, add a pH adjuster to adjust the pH to 4.5, stir, cool to room temperature, fill, and package to obtain the lubricating liquid.

[0063] Example 7

[0064] The present invention provides a human body lubricant, comprising the following raw material ratios: 12 wt% propylene glycol, 18 wt% glycerol, 0.4 wt% sodium hyaluronate, 0.6 wt% carbomer, 1.5 wt% arginine, 0.08 wt% silver ion (calculated as silver compound), 0.08 wt% pH adjuster, 1.2 wt% betaine, and the balance being purified water. The preparation method is as follows:

[0065] S1: Mix the silver ion functional components in the metabolites of Lactococcus lactis with purified water and stir them evenly at 150 r / min and 38°C;

[0066] S2: Add carbomer, propylene glycol, and glycerin in sequence and continue stirring until completely dispersed;

[0067] S3: Add sodium hyaluronate, arginine and betaine and mix well;

[0068] S4: Finally, add a pH adjuster to adjust the pH to 5.0, stir, cool to room temperature, fill, and package to obtain the lubricating liquid.

[0069] Example 8

[0070] The present invention provides a human body lubricant, comprising: 8 wt% propylene glycol, 12 wt% glycerol, 0.2 wt% sodium hyaluronate, 0.4 wt% carbomer, 1.2 wt% arginine, 0.03 wt% silver ion (calculated as silver compound), 0.03 wt% pH adjuster, 0.8 wt% betaine, 0.6 wt% coumarin, and the balance being purified water. The preparation method is as follows:

[0071] S1: Mix the silver ion functional components in the metabolites of Streptococcus salivarius with purified water and stir them evenly at 80 r / min and 32°C;

[0072] S2: Add carbomer, propylene glycol, and glycerin in sequence and continue stirring until completely dispersed;

[0073] S3: Add sodium hyaluronate, arginine, betaine and coumarin and mix well;

[0074] S4: Finally, add a pH adjuster to adjust the pH to 4.2, stir, cool to room temperature, fill, and package to obtain the lubricating liquid.

[0075] In order to test the antibacterial effect of the present invention, the present invention was compared with a certain brand on the market. The antibacterial effects were divided into significant effect, effective, and ineffective. The comparison results are shown in the following table:

[0076] Group Number of cases Significant effect efficient invalid Total efficiency The present invention 100 70 25 5 95％ A certain brand 100 45 30 25 75％

[0077] It can be seen from the above table that the present invention has a strong antibacterial effect and a good effect.

[0078] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A human body lubricating fluid, characterized in that: Contains the following ingredients: Propylene glycol, 5-15 wt%; Glycerol, accounting for 10-20wt%; Sodium hyaluronate, 0.1-0.5wt%; Carbomer, accounting for 0.2-0.8wt%; Arginine, 0.5-2 wt%; Silver ions (calculated as silver compounds), accounting for 0.01-0.1wt%; pH regulator, accounting for 0.01-0.1wt%; Betaine, accounting for 0.5-1.5wt% Purified water, balance.

2. A human body lubricating fluid according to claim 1, characterized in that: The betaine can be replaced by coumarin, and the content of the coumarin when replaced is 0.5-1.5 wt%.

3. A human body lubricating fluid according to claim 1 or 2, characterized in that: When betaine and coumarin are contained at the same time, the contents are 0.5-1.5 wt% and 0.2-0.8 wt% respectively.

4. A human body lubricating fluid according to claim 1, characterized in that: The silver ions are derived from metabolites of specific bacterial species, and the bacterial species is selected from at least one of Lactococcus lactis, Streptococcus salivarius, and Lactobacillus reuteri.

5. A human body lubricating fluid according to claim 4, characterized in that: The lactococcus lactis is prepared by the following process to obtain a silver ion-containing functional component named LL-silver ion functional component: 25-35 g / L glucose, 10-20 g / L beef extract powder and 5-8 g / L yeast extract powder are added to an MRS culture medium, 2-5 wt% of freeze-dried bacterial powder is inoculated, and the culture is statically cultured at 37°C±1°C for 20-30 hours until OD600 is 0.8-1.2, silver nitrate is added to a final concentration of 8-10 mg / L, and the culture is continued for 3-5 hours, followed by centrifugation to collect the bacterial cells, soaking them in 0.1 M hydrochloric acid for 2-3 hours, and then filtering to obtain a filtrate.

6. A human body lubricating fluid according to claim 4, characterized in that: The Streptococcus salivarius obtains a silver ion-containing functional component named SS-silver ion functional component through the following process: anaerobically culturing in TPY medium at 37°C±1°C for 12-16 hours to an OD600 of 0.8-1.0, continuing to culture with a ventilation volume of 0.8-1.2 vvm and a stirring speed of 150-200 rpm to an OD600 of 1.0-1.5, adding silver nitrate and 0.3-0.6% chitosan at a final concentration of 6-8 mg / L for reaction for 2-4 hours, and centrifuging to obtain the supernatant, which is concentrated through a 10 kDa ultrafiltration membrane to obtain filtrate B.

7. The human body lubricating fluid according to claim 1, characterized in that: The Lactobacillus reuteri is prepared by the following process to obtain a silver ion-containing functional component named RL-silver ion functional component: 2-4 g / L triammonium citrate and 2-3 g / L dipotassium hydrogen phosphate are added to a modified MRS culture medium, 3-6 wt% of freeze-dried bacterial powder is inoculated, and the culture is statically cultured at 37°C±1°C for 24-36 hours, silver nitrate and 0.1-0.3% citric acid are added to the culture medium to a final concentration of 9-12 mg / L for 2-4 hours, and the bacteria are crushed and then centrifuged at high speed at 12000-15000 rpm×15-20 minutes to obtain a supernatant.

8. The method for preparing a human body lubricating fluid according to any one of claims 1 to 7, wherein: The following steps are involved: At least one of the LL-silver ion functional component, the SS-silver ion functional component, and the RL-silver ion functional component is mixed with purified water, and stirred evenly at 50-200 r / min and 30-40° C. Carbomer, propylene glycol, and glycerin are added in sequence and stirred until completely dispersed. Sodium hyaluronate, arginine, and betaine / coumarin are then added and stirred evenly. Finally, a pH adjuster is added to adjust the pH to 4.0-5.

5. After stirring and cooling to room temperature, the mixture is filled and packaged to obtain a lubricating liquid.