Intelligent sub-packaging equipment and sub-packaging method for stem cell exosome freeze-dried powder

Abstract

The invention discloses intelligent stem cell exosome freeze-dried powder split charging equipment and a split charging method, and relates to the technical field of freeze-dried powder filling equipment.The intelligent stem cell exosome freeze-dried powder split charging equipment comprises a packaging bottle conveying device, a freeze-dried powder liquid filling assembly and an additive filling assembly, and a filling device connecting plate is arranged on one side of the packaging bottle conveying device; the freeze-dried powder liquid filling assembly and the additive filling assembly are both connected to the side, close to the packaging bottle conveying device, of the filling device connecting plate. The liquid stem cell exosomes are firstly filled and then freeze-dried, so that the stem cell exosomes are prevented from being damaged, the quality and the effect of freeze-dried powder are ensured, the split charging equipment can simultaneously perform uninterrupted multi-group filling work through a linked and staggered filling structure, the production efficiency is ensured, and the production cost is reduced. The situation of liquid leakage in the refilling process is avoided through the intelligent monitoring equipment, the cleanliness of the production environment is guaranteed, and waste of raw materials is avoided.

Description

Technical Field

[0001] The present application relates to the technical field of freeze-dried powder filling equipment, and more specifically, to an intelligent packaging device and packaging method for stem cell exosome freeze-dried powder. Background Art

[0002] Exosomes are not easy to preserve and need to be stored at a low temperature of -80°C or 2-8°C for a short period of time. They also have high requirements for transportation. Low-temperature transportation and storage are also inconvenient for use. Therefore, freeze-drying solves this problem. Freeze-dried powder is a sterile powder injection made by freezing the drug liquid into a solid state in a sterile environment, and then vacuuming it to sublimate and dry the water.

[0003] In order to prevent the freeze-dried powder from being damaged and to maintain its stability, some additives need to be added before freezing. However, in the production and packaging of existing freeze-dried powder, the liquid medicine is generally directly frozen into a solid state before packaging. This requires a large amount of liquid medicine and additives to be mixed and frozen before packaging, and the liquid medicine and additives need to be stirred and mixed evenly during the freezing period. Existing freeze-dried powder production and packaging equipment is mostly used for freeze-drying and packaging of liquid medicines. Its overall freezing method may result in uneven freezing, which may damage the stem cell exosomes during the freeze-thaw process. Since stem cell exosomes are easily damaged, the mixing and stirring action before freeze-drying may also cause damage to the stem cells.

[0004] Therefore, in response to the above-mentioned technical problems, an intelligent packaging device and packaging method for stem cell exosome freeze-dried powder are proposed. Summary of the Invention

[0005] In order to overcome the above-mentioned defects of the prior art, the present application provides an intelligent packaging device and packaging method for stem cell exosome freeze-dried powder to solve the problems raised in the above-mentioned background technology.

[0006] To achieve the above objectives, the present application provides the following technical solutions: an intelligent packaging device for stem cell exosome freeze-dried powder, comprising a packaging bottle conveyor, a freeze-dried powder liquid filling component, and an additive filling component, wherein a filling device connecting plate is provided on one side of the packaging bottle conveyor, and the freeze-dried powder liquid filling component and the additive filling component are both connected to the side of the filling device connecting plate close to the packaging bottle conveyor; Among them, the freeze-dried powder liquid filling assembly includes a freeze-dried powder liquid filling box and multiple groups of freeze-dried powder filling tubes, and the additive filling assembly includes an additive filling box and multiple groups of additive filling tubes. One side of the freeze-dried powder liquid filling box and the additive filling box are both connected to a lifting filling connecting plate, and one side of the lifting filling connecting plate is connected to a drive transmission assembly.

[0007] Preferably, the additive filling assembly is arranged between the freeze-dried powder liquid filling assembly and the packaging bottle conveying device, multiple groups of the freeze-dried powder filling tube arrays are inserted into the freeze-dried powder liquid filling box, and multiple groups of the additive filling tube arrays are inserted into the additive filling box.

[0008] Preferably, a mounting connecting plate is connected between the driving transmission assembly and the filling device connecting plate, the driving transmission assembly includes two sets of reciprocating driving wheels and two sets of driving cranks, and a driving belt is connected between the two sets of reciprocating driving wheels.

[0009] Preferably, the transmission crank is connected to the center position of the reciprocating drive wheel through a rotating shaft, and the end of the transmission crank away from the reciprocating drive wheel is connected to a connecting column, and two groups of the connecting columns are respectively connected to the two ends of the lifting and filling connecting plate.

[0010] Preferably, the reciprocating drive wheel is connected to a wheel shaft at one end away from the transmission crank, and one end of the wheel shaft is connected to the filling device connecting plate through a bearing, and a driving gear is fixedly sleeved on the outer side of one end of the wheel shaft.

[0011] Preferably, a reciprocating telescopic cylinder is provided on the side of the filling device connecting plate away from the packaging bottle conveying device, and a driving gear plate is connected to the output shaft of the reciprocating telescopic cylinder, the two groups of driving gears are respectively provided on both sides of the driving gear plate, and driving racks meshing with the driving gears are provided on both sides of the driving gear plate.

[0012] Preferably, the freeze-dried powder filling tube is a straight tube, the additive filling tube is an inverted L-shaped tube, and the outer sides of the bottom ends of the freeze-dried powder filling tube and the additive filling tube are both sleeved with filling heads, a limit detection ring is provided on the top of the filling head, and a thin film pressure sensor is connected to the bottom of the limit detection ring.

[0013] Preferably, both ends of the bottom of the freeze-dried powder liquid filling box are connected to industrial cameras, and one end of the freeze-dried powder liquid filling box is connected to a freeze-dried powder liquid feeding hose, and one end of the additive filling box is connected to an additive feeding hose.

[0014] Preferably, the packaging bottle conveying device is a hollow box structure with openings at both ends and the top, and a fixed-distance conveyor belt is provided at the top center position of the packaging bottle conveying device, and two groups of mutually symmetrical bottle mouth limit blocks are respectively provided on both sides of the fixed-distance conveyor belt, and the bottle mouth limit blocks are inverted L-shaped, and the filling head is arranged on the symmetry axis of the two groups of bottle mouth limit blocks.

[0015] Preferably, a packaging method of a stem cell exosome freeze-dried powder intelligent packaging device comprises the following steps: Step 1: First, place the cleaned and sterilized freeze-dried powder storage bottles into the packaging bottle conveyor for equidistant conveyance, and then carry out filling processing when conveyed to the bottom of the freeze-dried powder liquid filling component and the additive filling component; Step 2: Industrial cameras at both ends of the freeze-dried powder liquid filling box identify the position of the bottles on the bottle conveyor and control the freeze-dried powder liquid filling component and additive filling component based on the identified position; Step 3: The freeze-dried powder filling tubes and the additive filling tubes are alternately inserted into multiple groups of storage bottles, and the stem cell exosomes or additives are filled into the storage bottles they are inserted into; Step 4: After the initial filling is completed, the lyophilized powder liquid filling component and the additive filling component perform opposite lifting and translational movements. After the movement, the lyophilized powder filling tube and the additive filling tube are inserted into adjacent storage bottles, and the storage bottles are filled with stem cell exosomes or additives. During the filling process, the stem cell exosomes and additives are mixed. Step 5: After the filling and mixing are completed, the bottle conveyor drives the filled bottles to the subsequent capping and freezing process equipment for the next filling process.

[0016] The technical effects and advantages of this application are: Compared with the existing technology, this intelligent packaging equipment and packaging method for stem cell exosome freeze-dried powder ensures that the stem cell exosomes are not damaged by first filling and then freeze-drying the liquid stem cell exosomes, thereby ensuring the quality and efficacy of the freeze-dried powder. The freeze-dried powder liquid filling component fills the stem cell exosomes into the storage bottle through the freeze-dried powder filling tube, and the additive filling component fills the required additives into the storage bottle through the additive filling tube. The filling of stem cell exosomes and additives is completed during the filling process.

[0017] Compared with the existing technology, this intelligent packaging equipment and packaging method for stem cell exosome freeze-dried powder can, through the linked and staggered filling structure, enable the packaging equipment to perform uninterrupted multiple groups of filling work at the same time, thereby ensuring production efficiency. The reciprocating telescopic cylinder drives the lifting and filling connecting plate to perform reciprocating translational lifting and lowering motion, and the lifting and filling connecting plate drives the additive filling component or the freeze-dried powder liquid filling component connected to it to move, and completes the lifting and translation actions during the movement, thereby completing the filling switching work, and the rotation directions of the two sets of drive gears are opposite, that is, the lateral movement directions of the additive filling component and the freeze-dried powder liquid filling component are opposite, but the lifting and lowering actions are synchronized.

[0018] Compared with the existing technology, this intelligent packaging equipment and packaging method for stem cell exosome freeze-dried powder uses intelligent monitoring equipment to avoid liquid leakage during the refilling process, ensuring the cleanliness of the production environment and avoiding waste of raw materials. The industrial cameras at both ends of the freeze-dried powder liquid filling box identify the position of the storage bottle on the packaging bottle conveyor, and control the freeze-dried powder liquid filling component and the additive filling component according to the identified position. When the filling head is inserted into the storage bottle, the limit detection ring abuts against the bottle mouth of the storage bottle to prevent the filling head from extending too deep. When the limit detection ring contacts the bottle mouth, the pressure information is received by the thin film pressure sensor, and the filling action is performed after receiving the pressure information to avoid liquid leakage due to failure to insert into the storage bottle. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the overall structure of this application; Figure 2 This is a schematic diagram of the structure of the freeze-dried powder liquid filling component of this application; Figure 3 This is a schematic structural diagram of the additive filling component of the present application; Figure 4 This is a schematic diagram of the structure of the filling head of this application; Figure 5 This is a schematic diagram of the structure of the connection structure at the installation connection plate of this application; Figure 6 This is a schematic diagram of the connection structure of the drive transmission assembly of the present application; Figure 7 This is a schematic structural diagram of the back side of the connecting plate of the filling device of this application; Figure 8 This is a schematic structural diagram of the packaging bottle conveying device of this application.

[0020] The accompanying drawings are marked as follows: 1. packaging bottle conveyor; 11. bottle mouth limit block; 12. fixed-distance conveyor belt; 2. filling device connecting plate; 21. reciprocating telescopic cylinder; 211. driving gear plate; 212. driving rack; 3. freeze-dried powder liquid filling assembly; 31. freeze-dried powder liquid filling box; 311. freeze-dried powder liquid feeding hose; 312. industrial camera; 32. freeze-dried powder filling tube; 321. filling head; 322. limit detection ring; 323. film pressure sensor; 33. lifting filling connecting plate; 34. drive transmission assembly; 341. transmission crank; 342. rotor shaft; 343. driving gear; 344. transmission belt; 345. connecting column; 346. reciprocating drive rotor; 35. mounting connecting plate; 4. additive filling assembly; 41. additive filling box; 411. additive feeding hose; 42. additive filling tube. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0022] As attached Figures 1 to 8 The intelligent packaging equipment for stem cell exosome freeze-dried powder shown in the figure includes a packaging bottle conveyor 1, a freeze-dried powder liquid filling component 3, and an additive filling component 4. A filling device connecting plate 2 is provided on one side of the packaging bottle conveyor 1, and the freeze-dried powder liquid filling component 3 and the additive filling component 4 are both connected to the filling device connecting plate 2 on the side close to the packaging bottle conveyor 1; Among them, the freeze-dried powder liquid filling component 3 includes a freeze-dried powder liquid filling box 31 and multiple groups of freeze-dried powder filling tubes 32, and the additive filling component 4 includes an additive filling box 41 and multiple groups of additive filling tubes 42. One side of the freeze-dried powder liquid filling box 31 and the additive filling box 41 are both connected with a lifting filling connecting plate 33, and one side of the lifting filling connecting plate 33 is connected to the driving transmission component 34; the freeze-dried powder storage bottles that have been disinfected are placed on the packaging bottle conveying device 1 for transportation, and the filling device connecting plate 2 is the main connecting structure of the entire filling equipment. The freeze-dried powder liquid filling component 3 fills the stem cell exosomes into the storage bottle through the freeze-dried powder filling tube 32, and at the same time, the additive filling component 4 fills the required additives into the storage bottle through the additive filling tube 42, and the filling action of the freeze-dried powder liquid filling component 3 and the additive filling component 4 is controlled by the driving transmission component 34.

[0023] As a preferred embodiment, the additive filling component 4 is arranged between the freeze-dried powder liquid filling component 3 and the packaging bottle conveyor 1, and multiple groups of freeze-dried powder filling tubes 32 are inserted into the freeze-dried powder liquid filling box 31 in an array, and multiple groups of additive filling tubes 42 are inserted into the additive filling box 41 in an array; the additive filling component 4 and the freeze-dried powder liquid filling component 3 are staggered to avoid collision during the mobile filling process, and the freeze-dried powder liquid filling box 31 and the additive filling box 41 are both provided with quantitative filling components, and the quantitative filling equipment is an existing mature technology, which can accurately and quantitatively transport liquid or solid through the freeze-dried powder filling tube 32 or the additive filling tube 42, and its specific implementation method and working principle can refer to the quantitative filling machine with publication number CN101565159B or the quantitative filling machine with publication number CN105692532B, and its specific working process will not be described in detail here.

[0024] As a preferred embodiment, a mounting connecting plate 35 is connected between the drive transmission assembly 34 and the filling device connecting plate 2. The drive transmission assembly 34 includes two sets of reciprocating drive wheels 346 and two sets of drive cranks 341, and a drive belt 344 is connected between the two sets of reciprocating drive wheels 346; the drive crank 341 is connected to the center position of the reciprocating drive wheel through a rotating shaft, and the end of the drive crank 341 away from the reciprocating drive wheel 346 is connected to a connecting column 345, and the two sets of connecting columns 345 are respectively connected to the two ends of the lifting filling connecting plate 33; the drive transmission assembly 34 is fixedly installed by the mounting connecting plate 35 On the mounting connecting plate 35, a group of reciprocating drive wheels 346 drives another group of reciprocating drive wheels 346 to rotate through a transmission belt 344, and the reciprocating drive wheels 346 drive the transmission crank 341 to rotate during the rotation, and the two groups of transmission cranks 341 drive the lifting and filling connecting plate 33 to perform reciprocating translational lifting and lowering motions through the connecting column 345 during the rotation, and the lifting and filling connecting plate 33 drives the additive filling component 4 or the freeze-dried powder liquid filling component 3 connected thereto to move, and completes the lifting and translational movements during the movement, thereby completing the filling switching work.

[0025] As a preferred embodiment, the reciprocating drive wheel 346 is connected to a wheel shaft 342 at one end away from the transmission crank 341, and one end of the wheel shaft 342 is connected to the filling device connecting plate 2 through a bearing, and a driving gear 343 is fixedly sleeved on the outer side of one end of the wheel shaft 342; a reciprocating telescopic cylinder 21 is provided on the side of the filling device connecting plate 2 away from the packaging bottle conveyor 1, and a driving gear plate 211 is connected to the output shaft of the reciprocating telescopic cylinder 21, two sets of driving gears 343 are respectively provided on both sides of the driving gear plate 211, and a driving rack 212 meshing with the driving gear 343 is provided on both sides of the driving gear plate 211; the reciprocating telescopic cylinder 21 is provided on both sides of the driving gear plate 211; The driving gear plate 211 is driven to perform telescopic movement, and the driving gear plate 211 drives the two sets of driving gears 343 to rotate by driving the driving rack 212 during the telescopic movement, and the driving gear 343 drives the reciprocating driving wheel 346 to rotate through the wheel shaft 342 during the rotation, and the rotation directions of the two sets of driving gears 343 are opposite, that is, the lateral movement directions of the additive filling component 4 and the freeze-dried powder liquid filling component 3 are opposite, but the lifting and lowering actions are synchronized, and the lateral movement distance of the additive filling component 4 and the freeze-dried powder liquid filling component 3 is the distance between the two adjacent freeze-dried powder filling tubes 32, and the reciprocating telescopic cylinder 21 performs continuous equidistant telescopic movement.

[0026] As a preferred embodiment, the freeze-dried powder filling tube 32 is a straight tube, and the additive filling tube 42 is an inverted L-shaped tube, and the outer sides of the bottom ends of the freeze-dried powder filling tube 32 and the additive filling tube 42 are both sleeved with a filling head 321, and a limit detection ring 322 is provided on the top of the filling head 321, and a film pressure sensor 323 is connected to the bottom of the limit detection ring 322; the additive filling tube 42 further avoids the movement path of the freeze-dried powder filling tube 32 through the inverted L-shaped tube to avoid collision during the movement, and the freeze-dried powder filling tube 32 is placed in the container 32. When the powder filling tube 32 and the additive filling tube 42 drop to the lowest point, the filling heads 321 to which they are connected are flush with each other, and when the filling head 321 is inserted into the storage bottle, the limit detection ring 322 abuts against the bottle mouth of the storage bottle to prevent the filling head 321 from extending too deep, and when the limit detection ring 322 contacts the bottle mouth, the film pressure sensor 323 receives the pressure information and performs the filling action after receiving the pressure information to avoid liquid leakage due to failure to insert the filling head 321 into the storage bottle.

[0027] As a preferred embodiment, both ends of the bottom of the freeze-dried powder liquid filling box 31 are connected to industrial cameras 312, and one end of the freeze-dried powder liquid filling box 31 is connected to a freeze-dried powder liquid feeding hose 311, and one end of the additive filling box 41 is connected to an additive feeding hose 411; the freeze-dried powder liquid filling box 31 identifies the position of the storage bottle through the industrial camera 312 to perform the filling work more accurately, and the industrial camera 312 is an existing mature technology and will not be described in detail here, and the freeze-dried powder liquid filling box 31 is connected to the container for storing stem cell exosomes through the freeze-dried powder liquid feeding hose 311, and the additive filling box 41 is connected to the container containing additives through the additive feeding hose 411, and the additives include but are not limited to proteins, sugars, buffers and antioxidants, and refining agents.

[0028] As a preferred embodiment, the packaging bottle conveying device 1 is a hollow box structure with openings at both ends and the top, and a fixed-distance conveyor belt 12 is provided at the top center position of the packaging bottle conveying device 1, and two groups of mutually symmetrical bottle mouth limit blocks 11 are respectively provided on both sides of the fixed-distance conveyor belt 12, and the bottle mouth limit blocks 11 are inverted L-shaped, and the filling head 321 is provided on the symmetry axis of the two groups of bottle mouth limit blocks 11; the packaging bottle conveying device 1 conveys the stored bottles at equal distances through the fixed-distance conveyor belt 12, and the fixed-distance conveyor belt 12 is a common basic equipment in this field and will not be described in detail here. The bottle mouth position of the stored bottles on the fixed-distance conveyor belt 12 is limited and positioned by the bottle mouth limit blocks 11, so that the filling head 321 can be more accurately extended into the bottle mouth.

[0029] As a preferred embodiment, a method for intelligent packaging of stem cell exosome freeze-dried powder comprises the following steps: Step 1: First, the cleaned and sterilized freeze-dried powder storage bottles are placed in the packaging bottle conveyor 1 for equidistant conveyance, and are filled when they are conveyed to the bottom of the freeze-dried powder liquid filling component 3 and the additive filling component 4; Step 2: The industrial cameras 312 at both ends of the freeze-dried powder liquid filling box 31 identify the position of the bottles on the bottle conveyor 1, and control the freeze-dried powder liquid filling component 3 and the additive filling component 4 according to the identified position; Step 3: The freeze-dried powder filling tubes 32 and the additive filling tubes 42 are alternately inserted into the multiple groups of storage bottles, and the stem cell exosomes or additives are filled into the storage bottles; Step 4: After the initial filling is completed, the lyophilized powder liquid filling assembly 3 and the additive filling assembly 4 perform opposite lifting and translational movements. After the movement, the lyophilized powder filling tube 32 and the additive filling tube 42 are inserted into adjacent storage bottles, and the stem cell exosomes or additives are filled into the storage bottles. During the filling process, the stem cell exosomes and additives are mixed. Step 5: After the filling and mixing are completed, the packaging bottle conveyor device 1 drives the filled storage bottles to the subsequent capping and freezing process equipment for the next filling process.

[0030] The working process of the present application is as follows: first, the cleaned and sterilized freeze-dried powder storage bottles are placed in the packaging bottle conveyor 1, and the storage bottles are transported at equal distances by the fixed-distance conveyor 12. The bottle mouth positions of the storage bottles on the fixed-distance conveyor 12 are limited and positioned by the bottle mouth limit blocks 11. During the conveying process, the industrial cameras 312 at both ends of the freeze-dried powder liquid filling box 31 identify the positions of the storage bottles on the packaging bottle conveyor 1, and control the freeze-dried powder liquid filling component 3 and the additive filling component 4 based on the identified positions. When the bottle is moved to the designated filling position, the reciprocating telescopic cylinder 21 drives the driving gear plate 211 to move telescopically. During the telescopic movement, the driving gear plate 211 drives the driving rack 212 to drive the two sets of driving gears 343 to rotate. During the rotation, the driving gear 343 drives the reciprocating driving wheel 346 to rotate through the wheel shaft 342. The reciprocating driving wheel 346 drives another set of reciprocating driving wheels 346 to rotate through the transmission belt 344. During the rotation, the reciprocating driving wheel 346 drives the transmission crank. 341 rotates, and during the rotation process, the two sets of transmission cranks 341 drive the lifting filling connecting plate 33 to perform reciprocating translational lifting and lowering motions through the connecting column 345, and the lifting filling connecting plate 33 drives the additive filling component 4 or the freeze-dried powder liquid filling component 3 connected thereto to move, and completes the lifting and lowering and translational motions during the movement, thereby completing the filling switching work, and the rotation directions of the two sets of driving gears 343 are opposite, that is, the lateral movement directions of the additive filling component 4 and the freeze-dried powder liquid filling component 3 are opposite, but the lifting and lowering motions are synchronized; When the filling head 321 is inserted into the storage bottle, the limit detection ring 322 is against the bottle mouth of the storage bottle to prevent the filling head 321 from extending too deep, and when the limit detection ring 322 contacts the bottle mouth, the film pressure sensor 323 receives the pressure information, and performs the filling action after receiving the pressure information to avoid liquid leakage due to failure to insert into the storage bottle. After the initial filling is completed, the freeze-dried powder liquid filling component 3 and the additive filling component 4 perform opposite lifting and translation movements, and after the movement, the freeze-dried powder filling tube 32 and the additive filling tube 42 are inserted into the adjacent storage bottles, and the storage bottles are filled with stem cell exosomes or additives, and the filled stem cell exosomes and additives are mixed during the filling process. After the filling and mixing are completed, the packaging bottle conveyor device 1 drives the filled storage bottle into the subsequent capping and freezing process equipment for the next filling.

[0031] Finally: The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application should be included in the scope of protection of the present application.

Claims

1. An intelligent packaging device for stem cell exosome freeze-dried powder, comprising a packaging bottle conveyor (1), a freeze-dried powder liquid filling component (3) and an additive filling component (4), characterized in that: A filling device connecting plate (2) is provided on one side of the packaging bottle conveying device (1), and the freeze-dried powder liquid filling component (3) and the additive filling component (4) are both connected to the side of the filling device connecting plate (2) close to the packaging bottle conveying device (1); The freeze-dried powder liquid filling assembly (3) includes a freeze-dried powder liquid filling box (31) and multiple groups of freeze-dried powder filling tubes (32), and the additive filling assembly (4) includes an additive filling box (41) and multiple groups of additive filling tubes (42). One side of each of the freeze-dried powder liquid filling box (31) and the additive filling box (41) is connected to a lifting filling connecting plate (33), and one side of the lifting filling connecting plate (33) is connected to a driving transmission assembly (34).

2. The intelligent packaging device for stem cell exosome freeze-dried powder according to claim 1, characterized in that: The additive filling assembly (4) is arranged between the freeze-dried powder liquid filling assembly (3) and the packaging bottle conveying device (1), and multiple groups of freeze-dried powder filling tubes (32) are inserted into the freeze-dried powder liquid filling box (31), and multiple groups of additive filling tubes (42) are inserted into the additive filling box (41).

3. The intelligent packaging device for stem cell exosome freeze-dried powder according to claim 1, characterized in that: A mounting connection plate (35) is connected between the drive transmission assembly (34) and the filling device connection plate (2). The drive transmission assembly (34) includes two sets of reciprocating drive wheels (346) and two sets of drive cranks (341), and a drive belt (344) is connected between the two sets of reciprocating drive wheels (346).

4. The intelligent packaging device for stem cell exosome freeze-dried powder according to claim 3, characterized in that: The transmission crank (341) is connected to the center of the reciprocating drive wheel via a rotating shaft, and one end of the transmission crank (341) away from the reciprocating drive wheel (346) is connected to a connecting column (345), and two groups of the connecting columns (345) are respectively connected to the two ends of the lifting and filling connecting plate (33).

5. The intelligent packaging device for stem cell exosome freeze-dried powder according to claim 4, characterized in that: One end of the reciprocating drive wheel (346) away from the transmission crank (341) is connected to a wheel shaft (342), and one end of the wheel shaft (342) is connected to the filling device connecting plate (2) through a bearing. A driving gear (343) is fixedly sleeved on the outer side of one end of the wheel shaft (342).

6. The intelligent packaging device for stem cell exosome freeze-dried powder according to claim 5, characterized in that: A reciprocating telescopic cylinder (21) is provided on a side of the filling device connecting plate (2) away from the packaging bottle conveying device (1), and a driving gear plate (211) is connected to the output shaft of the reciprocating telescopic cylinder (21). Two sets of driving gears (343) are respectively provided on both sides of the driving gear plate (211), and driving racks (212) meshing with the driving gears (343) are provided on both sides of the driving gear plate (211).

7. The intelligent packaging device for stem cell exosome freeze-dried powder according to claim 1, characterized in that: The freeze-dried powder filling tube (32) is a straight tube, and the additive filling tube (42) is an inverted L-shaped tube. The outer sides of the bottom ends of the freeze-dried powder filling tube (32) and the additive filling tube (42) are both sleeved with filling heads (321). A limit detection ring (322) is provided on the top of the filling head (321), and a thin film pressure sensor (323) is connected to the bottom of the limit detection ring (322).

8. The intelligent packaging device for stem cell exosome freeze-dried powder according to claim 1, characterized in that: Both ends of the bottom of the freeze-dried powder liquid filling box (31) are connected to industrial cameras (312), one end of the freeze-dried powder liquid filling box (31) is connected to a freeze-dried powder liquid feeding hose (311), and one end of the additive filling box (41) is connected to an additive feeding hose (411).

9. The intelligent packaging device for freeze-dried stem cell exosome powder according to claim 1, characterized in that: The packaging bottle conveying device (1) is a hollow box structure with both ends and a top open, and a fixed-distance conveyor belt (12) is provided at the top center position of the packaging bottle conveying device (1), and two groups of mutually symmetrical bottle mouth limit blocks (11) are respectively provided on both sides of the fixed-distance conveyor belt (12), and the bottle mouth limit blocks (11) are inverted L-shaped, and the filling head (321) is provided on the symmetry axis of the two groups of bottle mouth limit blocks (11).

10. A method for packaging a stem cell exosome freeze-dried powder intelligent packaging device, using the stem cell exosome freeze-dried powder intelligent packaging device according to any one of claims 1 to 9, characterized in that: The packaging method comprises the following steps: Step 1: First, the cleaned and sterilized freeze-dried powder storage bottles are placed in the packaging bottle conveyor (1) for equidistant conveyance, and are filled when conveyed to the bottom of the freeze-dried powder liquid filling component (3) and the additive filling component (4); Step 2: The industrial cameras (312) at both ends of the freeze-dried powder liquid filling box (31) identify the position of the bottles stored on the bottle conveyor (1), and control the freeze-dried powder liquid filling component (3) and the additive filling component (4) according to the identified position; Step 3: The freeze-dried powder filling tubes (32) and the additive filling tubes (42) are respectively inserted into the plurality of storage bottles in an interlaced manner, and the stem cell exosomes or additives are filled into the storage bottles into which they are inserted; Step 4: After the initial filling is completed, the lyophilized powder liquid filling component (3) and the additive filling component (4) perform opposite lifting and translational movements, and after the movement, the lyophilized powder filling tube (32) and the additive filling tube (42) are inserted into adjacent storage bottles, and the stem cell exosomes or additives are filled into the storage bottles, and the stem cell exosomes and additives are mixed during the filling process; Step 5: After the filling and mixing are completed, the bottle conveying device (1) drives the filled bottles to the subsequent capping and freezing process equipment for the next filling process.

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