Traditional Chinese medicine for treating alopecia areata

Abstract

The invention discloses a traditional Chinese medicine for treating alopecia areata. The traditional Chinese medicine is prepared from the following components in parts by weight: 0.15 part of menthol, 0.17 part of white vaseline, 0.3 part of glycerol, 0.8 part of liquid paraffin, 0.9 part of cortex dictamni, 0.1 part of radix sophorae flavescentis, 0.15 part of rheum officinale, 9-15 parts of poria cocos, 13-19 parts of herba lysimachiae, 13-19 parts of centipede, 5-11 parts of radix euphorbiae lantu, 15-21 parts of honeysuckle, 17-23 parts of horse oil, 11-17 parts of liquorice, 25-31 parts of aloe, 27-33 parts of radix arnebiae seu lithospermi, 0.5 part of borneol, 0.3 part of methyl salicylate and 0.9 part of zaocys dhumnade. The medicine has obvious effect on treating alopecia areata and small toxic and side effects.

Description

Technical Field

[0001] The invention relates to a traditional Chinese medicine for treating alopecia areata. Background Art

[0002] Alopecia areata is a common autoimmune disease characterized by sudden, localized hair loss, forming sharply demarcated, round or oval patches. Alopecia areata is a non-scarring hair loss caused by the immune system mistakenly attacking hair follicles. It can occur at any age but is most common in people under 30. The skin in the affected area remains normal, without inflammation or scaling. The condition may affect the scalp, eyebrows, eyelashes, beard, and body hair.

[0003] The causes of alopecia areata are complex, with modern medicine linking autoimmune, genetic, and psychiatric factors. Existing treatments, such as hormone injections and minoxidil, suffer from significant side effects and high recurrence rates. For details, see Chinese patent CN201680054554.7. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a traditional Chinese medicine for treating alopecia areata, which has obvious therapeutic effect on alopecia areata and less toxic and side effects.

[0005] In order to solve the above technical problems, the present invention provides a traditional Chinese medicine for treating alopecia areata. The traditional Chinese medicine comprises the following components in parts by weight: 0.15 parts of menthol, 0.17 parts of white vaseline, 0.3 parts of glycerin, 0.8 parts of liquid paraffin, 0.9 parts of Dictamnus cortex, 0.1 parts of Sophora flavescens, 0.15 parts of Rhubarb, 9-15 parts of Poria cocos, 13-19 parts of Ice Vanilla, 13-19 parts of Scolopendra subspinipes, 5-11 parts of Wolfberry, 15-21 parts of Honeysuckle, 17-23 parts of Horse Oil, 11-17 parts of Licorice, 25-31 parts of Aloe, 27-33 parts of Lithospermum officinale, 0.5 parts of Borneolum Syntheticum, 0.3 parts of Methyl Salicylate and 0.9 parts of Snakehead Garland.

[0006] The Chinese medicine for treating alopecia areata described in the present invention is effective in treating alopecia areata with minimal toxic side effects. The pharmacological effects can be divided into the following four major directions. The synergistic effects of the various components embody the characteristics of combining holistic conditioning with local treatment in traditional Chinese medicine:

[0007] 1. Clear away heat, cool blood, detoxify and cure rashes

[0008] Lithospermum officinale (27-33 parts): It is cold in nature and enters the Heart and Liver meridians. It has the effects of cooling blood, activating blood circulation, detoxifying and clearing rashes. It can improve blood-heat type hair loss.

[0009] Honeysuckle (15-21 parts): sweet, cold and light in nature, it clears away heat and detoxifies, and inhibits inflammatory reactions in hair follicles.

[0010] Rhubarb (0.15 parts): bitter and cold, it can relieve heat, and contains anthraquinones that can improve local microcirculation.

[0011] 2. Dispel wind and relieve itching, promote blood circulation and promote hair growth

[0012] Centipede (13-19 portions): Pungent and warm, it can dispel wind and dredge meridians. According to the Medical Records of Combining Chinese and Western Medicine, it is good at regulating brain and nerves.

[0013] Black-banded snake (0.9 parts): It can clear away wind and dredge meridians, and improve local blood circulation in the scalp.

[0014] Dictamnus Cortex (0.9 parts): bitter, cold and damp-drying, suitable for skin itching caused by wind-heat and dampness.

[0015] 3. Drying dampness and strengthening the spleen, strengthening the body

[0016] Poria (9-15 parts): Sweet and mild, it can dissipate dampness, strengthen the spleen and calm the mind, and improve the biochemical metabolism of Qi and blood by regulating the function of the spleen and stomach.

[0017] Licorice (11-17 parts): harmonizes various medicines, has anti-inflammatory and anti-allergic effects, and contains glycyrrhizic acid glycoside which can reduce apoptosis of hair follicle cells.

[0018] Wolfsbane (5-11 parts): It has a bitter and pungent taste and can dry out dampness and kill insects. However, attention should be paid to its toxicity (it is recommended to use it after processing).

[0019] 4. Moisturizes the skin and penetrates the skin, guiding the medicine to the meridians

[0020] Horse oil (17-23 parts): Animal-based, rich in unsaturated fatty acids, promotes drug penetration.

[0021] Borneol (0.5 parts): aromatic and invigorating, increases the permeability of the blood-brain barrier. Modern research shows that it can increase the bioavailability of drugs by 3-5 times.

[0022] Aloe vera (25-31 parts): nourishes yin and moisturizes dryness, and its polysaccharide components can repair the skin barrier function.

[0023] The preparation steps are as follows:

[0024] (1) Add 8 times the amount of water to the bark of Dictamnus chinensis, Sophora flavescens, Rhubarb, Lithospermum erythrorhizon, and Stellera chamaejasma and boil them twice. The combined filtrate is concentrated to a relative density of 1.15 (60°C).

[0025] (2) Ultrafine grinding of centipede and snake is mixed with the above extract;

[0026] (3) Add melted horse oil, vaseline, and liquid paraffin, stir and cool to 50°C, then add menthol, borneol, and methyl salicylate;

[0027] (4) After homogenization and emulsification, the mixture is packaged into an ointment for external use. DETAILED DESCRIPTION

[0028] Example 1:

[0029] A traditional Chinese medicine for treating alopecia areata comprises the following components in parts by weight: 0.15 parts of menthol, 0.17 parts of white vaseline, 0.3 parts of glycerin, 0.8 parts of liquid paraffin, 0.9 parts of Dictamnus cortex, 0.1 parts of Sophora flavescens, 0.15 parts of Rhubarb, 9 parts of Poria cocos, 13 parts of Herba Lycopodii, 13 parts of Scolopendra subspinipes, 5 parts of Wolfbane, 15 parts of Honeysuckle, 17 parts of Horse Oil, 11 parts of Licorice, 25 parts of Aloe, 27 parts of Lithospermum officinale, 0.5 parts of Borneolum Syntheticum, 0.3 parts of Methyl Salicylate, and 0.9 parts of Snakehead Garland.

[0030] Example 2:

[0031] A traditional Chinese medicine for treating alopecia areata comprises the following components in parts by weight: 0.15 parts of menthol, 0.17 parts of white vaseline, 0.3 parts of glycerin, 0.8 parts of liquid paraffin, 0.9 parts of Dictamnus cortex, 0.1 parts of Sophora flavescens, 0.15 parts of Rhubarb, 12 parts of Poria cocos, 16 parts of Herba Lycopodii, 16 parts of Scolopendra subspinipes, 8 parts of Wolfsbane, 18 parts of Honeysuckle, 20 parts of Horse Oil, 14 parts of Licorice, 28 parts of Aloe, 30 parts of Lithospermum officinale, 0.5 parts of Borneolum Syntheticum, 0.3 parts of Methyl Salicylate, and 0.9 parts of Snakehead Garland.

[0032] Example 3:

[0033] A traditional Chinese medicine for treating alopecia areata comprises the following components in parts by weight: 0.15 parts of menthol, 0.17 parts of white vaseline, 0.3 parts of glycerin, 0.8 parts of liquid paraffin, 0.9 parts of Dictamnus cortex, 0.1 parts of Sophora flavescens, 0.15 parts of Rhubarb, 15 parts of Poria cocos, 19 parts of Herba Lycopodii, 19 parts of Scolopendra subspinipes, 11 parts of Wolfbane, 21 parts of Honeysuckle, 23 parts of Horse Oil, 17 parts of Licorice, 31 parts of Aloe, 33 parts of Lithospermum officinale, 0.5 parts of Borneolum Syntheticum, 0.3 parts of Methyl Salicylate, and 0.9 parts of Snakehead Garland.

[0034] Evidence of efficacy:

[0035] A comparative experiment was conducted to verify the effectiveness of the Chinese medicine for treating alopecia areata described in this application.

[0036] 1. Recruit volunteers, aged 18-60 years, 25 men and 25 women (total 50 participants), who are required to be clinically diagnosed with alopecia areata (single or multiple hair loss patches, duration of disease ≤ 2 years) and have not used hormone / immunosuppressant treatment in the past 3 months.

[0037] Exclusion criteria:

[0038] Patients with other autoimmune diseases (such as hyperthyroidism, vitiligo); local scalp infection or trauma; pregnant women, breastfeeding women or people with allergic constitutions.

[0039] 2. Grouping method:

[0040] The stratified random method was used: after stratification by gender (male / female) and age (≤40 years >40 years), the subjects were randomly divided into an experimental group (25 people) and a blank control group (25 people).

[0041] 3. Comparative experiment:

[0042]

[0043] Note: The control group used a vaseline-based placebo (without active ingredients) to ensure a blind design. The experimental group used the formula of Example 2 above and the ointment was prepared using the following steps:

[0044] The preparation steps are as follows:

[0045] (1) Add 8 times the amount of water to the bark of Dictamnus chinensis, Sophora flavescens, Rhubarb, Lithospermum erythrorhizon, and Stellera chamaejasma and boil them twice. The combined filtrate is concentrated to a relative density of 1.15 (60°C).

[0046] (2) Ultrafine grinding of centipede and snake is mixed with the above extract;

[0047] (3) Add melted horse oil, vaseline, and liquid paraffin, stir and cool to 50°C, then add menthol, borneol, and methyl salicylate;

[0048] (4) After homogenization and emulsification, the mixture is packaged into an ointment for external use.

[0049] 4. Observation indicators

[0050] 1. Main efficacy indicators

[0051] Hair regrowth rate: The percentage of regrowth area in the hair loss area was calculated by standardized scalp photography and image analysis software.

[0052] 2. Secondary efficacy indicators

[0053] Follicle microscopy: hair follicle density, diameter of new hair.

[0054] Traditional Chinese Medicine syndrome scoring: degree of scalp itching, erythema, and desquamation.

[0055] 3. Safety indicators

[0056] Local irritation reaction (erythema, burning sensation, etc.).

[0057] Liver and kidney function (tested before and after medication).

[0058] Experimental results:

[0059] After 12 weeks, there was no change in the alopecia areata condition in the blank control group. In the experimental group, 21 people experienced hair regeneration, with the regeneration area percentage ranging from 20% to 50%. The hair quality was normal, with no scalp itching, erythema, or peeling, and no local irritation reaction (erythema, burning sensation, etc.). Liver and kidney functions were also normal.

Claims

1. A Chinese medicine for treating alopecia areata, characterized in that The composition is recorded by weight as follows: 0.15 parts of menthol, 0.17 parts of white vaseline, 0.3 parts of glycerin, 0.8 parts of liquid paraffin, 0.9 parts of Dictamnus cortex, 0.1 parts of Sophora flavescens, 0.15 parts of Rhubarb, 9-15 parts of Poria cocos, 13-19 parts of Ice Vanilla, 13-19 parts of Scolopendra, 5-11 parts of Wolfbane, 15-21 parts of Honeysuckle, 17-23 parts of Horse Oil, 11-17 parts of Licorice, 25-31 parts of Aloe, 27-33 parts of Lithospermum officinale, 0.5 parts of Borneolum Syntheticum, 0.3 parts of Methyl Salicylate and 0.9 parts of Garcinia charantia.

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