Nutritional composition for promoting postoperative tissue repair and metabolic regulation

Abstract

The invention relates to a nutritional composition for promoting postoperative tissue repair and metabolic regulation. The invention relates to an anti-fatigue health-care food, which is prepared from the following ingredients in parts by mass: 118.62 to 284.55 parts of maltodextrin, 30.86 to 82.63 parts of solid corn syrup, 57.59 to 161.4 parts of resistant dextrin, 13.27 to 32.16 parts of fructo-oligosaccharide, 142.32 to 314.6 parts of whey protein peptide, 79.6 to 153.37 parts of sodium caseinate, 29.36 to 70.66 parts of fish oil, 83.46 to 162.94 parts of medium chain triglyceride, 4.87 to 12.08 parts of compound vitamins and 40.32 to 95.59 parts of compound minerals. After a postoperative rat is fed with the nutritional composition for two weeks, the serum protein level of the rat can be remarkably improved, inflammatory factors in serum can be reduced, the immune globulin level in the serum can be improved, and spleen and thymus indexes can be improved, so that wound healing and postoperative recovery of the postoperative rat can be effectively promoted; good application prospects are realized in the aspects of promoting tissue repair and metabolic regulation of postoperative patients.

Description

Technical Field

[0001] The present invention relates to the technical field of nutritional foods, and in particular to a nutritional composition for promoting postoperative tissue repair and metabolic regulation. Background Art

[0002] Malnutrition in surgical patients is a multifactorial process, primarily including: insufficient food intake due to the underlying disease; a systemic stress response triggered by surgical trauma, which significantly enhances the body's catabolism; decreased digestion and absorption due to anesthesia and postoperative gastrointestinal dysfunction; and adverse reactions such as anorexia and mucositis caused by adjuvant treatments such as radiotherapy and chemotherapy. Malnutrition not only impairs the physiological functions of tissues and organs and impairs wound healing, but also increases surgical risk, the incidence and mortality of postoperative complications (such as infection and anastomotic leakage), prolonged ICU and hospital stays, and increased medical costs, ultimately impacting patients' clinical outcomes and quality of life.

[0003] Nutritional support can improve the clinical outcomes of surgical patients and reduce the incidence and mortality of infectious complications. Postoperative nutritional support is crucial for maintaining the nutritional status of patients in the catabolic stage. Appropriate postoperative nutritional support can alleviate the patient's catabolic state and lean tissue loss, help patients get out of bed early and recover as quickly as possible, significantly reduce the incidence of postoperative complications, and thus improve clinical outcomes. However, there is currently no comprehensive nutritional combination that can simultaneously meet the energy needs, metabolic regulation, and tissue repair of postoperative patients. Summary of the Invention

[0004] To solve the above problems, the present invention provides a nutritional composition that promotes postoperative recovery and metabolic regulation. By scientifically proportioning multiple nutrients, a multi-target regulatory mechanism is implemented to promote postoperative trauma repair, improve metabolic disorders, enhance immune function, accelerate the recovery process, and reduce the incidence of postoperative complications. It is suitable for nutritional support during the recovery period after various types of surgery.

[0005] Specifically, the present invention provides the following technical solutions:

[0006] The first aspect of the present invention provides a nutritional composition for promoting postoperative tissue repair and metabolic regulation, comprising the following ingredients in parts by mass: 118.62-284.55 parts of maltodextrin, 30.86-82.63 parts of solid corn syrup, 57.59-161.4 parts of resistant dextrin, 13.27-32.16 parts of oligofructose, 142.32-314.6 parts of whey protein peptides, 79.6-153.37 parts of sodium caseinate, 29.36-70.66 parts of fish oil, 83.46-162.94 parts of medium-chain triglycerides, 4.87-12.08 parts of compound vitamins, and 40.32-95.59 parts of compound minerals.

[0007] Postoperative patients are in a hypermetabolic state, facing multiple challenges such as tissue repair, immune regulation, and gastrointestinal function recovery. The present invention utilizes a rational combination of multiple nutrients and regulates their content. Through the synergistic effect of these nutrients, the prepared nutritional composition can effectively regulate postoperative metabolism, promote tissue damage, enhance immunity, and improve gastrointestinal function, thereby fully supporting patients' postoperative nutritional supplementation needs. Specifically: the present invention provides immediate energy support for postoperative patients by adding appropriate amounts of maltodextrin and solid corn syrup to the nutritional composition, while maintaining postoperative glycogen reserves and reducing protein decomposition, thereby improving the patient's muscle strength and comfort; the introduction of appropriate amounts of resistant dextrin and oligofructose can selectively proliferate intestinal probiotics, improve intestinal motility, and reduce postoperative gastrointestinal discomfort, and compared with other oligosaccharides, oligofructose has a lower glycemic index and is more suitable for patients with postoperative stress hyperglycemia. At the same time, oligosaccharides can significantly increase the absorption rate of calcium and magnesium through the short-chain fatty acids produced by specific fermentation, which is beneficial to promote bone repair in postoperative patients; in addition, by adding an appropriate amount of whey protein peptides to the nutritional composition, it can provide high-quality protein with high bioavailability, provide essential amino acids, and promote wound healing and tissue repair; at the same time, an appropriate amount of sodium caseinate is introduced to provide sustained release Protein supports a long-term tissue repair process; an appropriate amount of fish oil can provide ω-3 fatty acids, thereby affecting the synthesis of various inflammatory mediators, cytokines and the activity of white blood cells, reducing the production and release of inflammatory mediators, promoting the phagocytic function of macrophages, and improving the body's anti-inflammatory and immune functions; medium-chain triglycerides are one of the main components of the nutritional composition, which are easy to digest and absorb, can quickly provide energy, and reduce the gastrointestinal burden; compound vitamins and compound minerals provide postoperative patients with the required vitamins and minerals to promote tissue repair, enhance immune function, etc.; under the synergistic effect of the above-mentioned appropriate amounts of each component, it can effectively improve the body's serum protein level, reduce the level of inflammatory factors, increase the level of immunoglobulins and increase organ indexes after surgery, promote rapid repair of postoperative tissues and improve gastrointestinal function, etc., accelerate the recovery process, and reduce the incidence of postoperative complications.

[0008] Furthermore, the compound vitamin comprises vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, choline bitartrate, L-carnitine tartrate and taurine.

[0009] Preferably, the vitamin A includes vitamin A palmitate, and an appropriate amount of vitamin A palmitate is introduced into the nutritional composition to maintain the integrity of the mucosa, enhance the function of immune cells, and promote wound healing.

[0010] Preferably, the vitamin B includes one or more of thiamine hydrochloride, vitamin B2, niacinamide, D-calcium pantothenate, pyridoxine hydrochloride, biotin, folic acid, and cyanocobalamin; the introduced B vitamins can participate in energy metabolism and cell repair, maintain the normal function of the nervous system, and enhance immunity.

[0011] Preferably, the vitamin D includes vitamin D3; vitamin D can regulate the immune system, and compared with vitamin D2, vitamin D3 is more conducive to promoting calcium absorption, so that blood calcium levels can quickly reach the standard to maintain bone health.

[0012] Preferably, the vitamin E includes dl-α-tocopheryl acetate, which is added as an antioxidant to protect cells from free radical damage and enhance immune function.

[0013] Preferably, the vitamin K includes vitamin K1. Adding an appropriate amount of vitamin K to the nutritional composition is beneficial to reducing postoperative bleeding and supporting tissue repair.

[0014] Additionally, L-carnitine tartrate in the vitamin complex promotes fatty acid oxidation. When used in conjunction with medium-chain triglycerides, the two synergistically enhance fat oxidation, improve energy expenditure, and reduce postoperative fat accumulation. Taurine, on the other hand, has antioxidant and cytoprotective properties, helping to support postoperative cell repair and regeneration.

[0015] Furthermore, the compound vitamin also contains maltodextrin.

[0016] More preferably, the compound vitamin is composed of the following ingredients in parts by mass: 0.031-0.114 parts of vitamin A palmitate, 0.016-0.048 parts of vitamin D3, 0.344-1.008 parts of dl-α-tocopheryl acetate, 0.003-0.011 parts of vitamin K1, 0.01-0.022 parts of thiamine hydrochloride, 0.005-0.014 parts of vitamin B2, 0.037-0.117 parts of niacinamide, 0.019-0.049 parts of calcium D-pantothenate, 0.012-0.046 parts of pyridoxine hydrochloride, 0.011-0.029 parts of biotin, 0.01-0.03 parts of folic acid, 0.015-0.042 parts of cyanocobalamin, and vitamin C. 0.331-1.074 parts, choline bitartrate 1.493-4.948 parts, L-carnitine tartrate 0.187-0.653 parts, taurine 0.132-0.37 parts, maltodextrin 1.191-3.94 parts.

[0017] Furthermore, the compound minerals include compound trace minerals and compound macro minerals, wherein the compound trace minerals include coated copper sulfate, ferric pyrophosphate, manganese sulfate, sodium selenite, zinc citrate, and potassium iodide, and the compound macro minerals include tricalcium phosphate, calcium carbonate, magnesium carbonate, potassium chloride, potassium citrate, and sodium citrate. Preferably, the mass ratio of the compound trace minerals to the compound macro minerals in the compound minerals is (1.03-2.49):(39.29-93.1).

[0018] Furthermore, the coating material of the coated copper sulfate includes but is not limited to maltodextrin, citric acid, etc. Compared with copper sulfate that is easy to react with other ingredients, the use of coated copper sulfate helps to reduce the loss of nutrients.

[0019] In the present invention, trace amounts of ferric pyrophosphate, manganese sulfate, and zinc citrate in the compound minerals are used to provide iron, manganese, and zinc to support hemoglobin synthesis, immune function, and tissue repair; at the same time, a trace amount of sodium selenite is introduced to provide selenium to enhance antioxidant effects and strengthen immune function, while a trace amount of potassium iodide can provide iodine to maintain thyroid function and support metabolism; in addition, the introduction of appropriate amounts of tricalcium phosphate, calcium carbonate, and magnesium carbonate can provide calcium and magnesium to maintain bone health and promote nerve and muscle function; the introduction of potassium chloride, potassium citrate, and sodium citrate can provide potassium and sodium to maintain electrolyte balance and support heart and muscle function.

[0020] Furthermore, the compound trace minerals also contain maltodextrin.

[0021] More preferably, the compound trace minerals are composed of the following components, calculated by mass: 0.06-0.15 parts of coated copper sulfate, 0.13-0.38 parts of ferric pyrophosphate, 0.33-0.92 parts of manganese sulfate, 0.05-0.09 parts of sodium selenite, 0.08-0.2 parts of zinc citrate, 0.02-0.04 parts of potassium iodide, and 0.52-1.1 parts of maltodextrin.

[0022] Furthermore, the compound macro-minerals also contain maltodextrin.

[0023] More preferably, the compound macro-minerals are composed of the following components, calculated by mass: 4.93-14.29 parts of tricalcium phosphate, 5.83-15.14 parts of calcium carbonate, 2.05-5.24 parts of magnesium carbonate, 4.05-9.88 parts of potassium chloride, 6.12-13.36 parts of potassium citrate, 5.93-17.19 parts of sodium citrate, and 2.29-6.3 parts of maltodextrin.

[0024] Furthermore, the nutritional composition also includes 1.97-4.53 parts of vanillin, which is used to adjust the taste of the nutritional composition, enhance the patient's appetite, and alleviate the patient's postoperative nausea, vomiting and other discomfort symptoms.

[0025] In some preferred embodiments of the present invention, the nutritional composition comprises the following ingredients in parts by mass: 118.62-284.55 parts of maltodextrin, 30.86-82.63 parts of solid corn syrup, 57.59-161.4 parts of resistant dextrin, 13.27-32.16 parts of oligofructose, 142.32-314.6 parts of whey protein peptides, 79.6-153.37 parts of sodium caseinate, 29.36-70.66 parts of fish oil, 83.46-162.94 parts of medium-chain triglycerides, 4.87-12.08 parts of complex vitamins, 1.03-2.49 parts of complex trace minerals, 39.29-93.1 parts of complex macrominerals, and 1.97-4.53 parts of vanillin; wherein, in parts by mass,

[0026] The compound vitamin is composed of the following ingredients: 0.031-0.114 parts of vitamin A palmitate, 0.016-0.048 parts of vitamin D3, 0.344-1.008 parts of dl-α-tocopheryl acetate, 0.003-0.011 parts of vitamin K1, 0.01-0.022 parts of thiamine hydrochloride, 0.005-0.014 parts of vitamin B2, 0.037-0.117 parts of niacinamide, 0.019-0.049 parts of calcium D-pantothenate, 0.012-0.046 parts of pyridoxine hydrochloride, 0.011-0.029 parts of biotin, 0.01-0.03 parts of folic acid, 0.015-0.042 parts of cyanocobalamin, and vitamin C. 0.331-1.074 parts, choline bitartrate 1.493-4.948 parts, L-carnitine tartrate 0.187-0.653 parts, taurine 0.132-0.37 parts, maltodextrin 1.191-3.94 parts;

[0027] The compound trace minerals are composed of the following ingredients: 0.06-0.15 parts of coated copper sulfate, 0.13-0.38 parts of ferric pyrophosphate, 0.33-0.92 parts of manganese sulfate, 0.05-0.09 parts of sodium selenite, 0.08-0.2 parts of zinc citrate, 0.02-0.04 parts of potassium iodide, and 0.52-1.1 parts of maltodextrin;

[0028] The compound macro-minerals are composed of the following components: 4.93-14.29 parts of tricalcium phosphate, 5.83-15.14 parts of calcium carbonate, 2.05-5.24 parts of magnesium carbonate, 4.05-9.88 parts of potassium chloride, 6.12-13.36 parts of potassium citrate, 5.93-17.19 parts of sodium citrate, and 2.29-6.3 parts of maltodextrin.

[0029] More preferably, the nutritional composition comprises the following ingredients in parts by mass: 136.28 parts of maltodextrin, 59.37 parts of solid corn syrup, 153.03 parts of resistant dextrin, 21.16 parts of oligofructose, 258.28 parts of whey protein peptides, 87.20 parts of sodium caseinate, 51.54 parts of fish oil, 150.28 parts of medium-chain triglycerides, 8.991 parts of complex vitamins, 1.92 parts of complex trace minerals, 48.66 parts of complex macrominerals, and 4.34 parts of vanillin; wherein, in parts by mass,

[0030] The compound vitamin is composed of the following ingredients: 0.060 parts of vitamin A palmitate, 0.039 parts of vitamin D3, 0.823 parts of dl-α-tocopheryl acetate, 0.011 parts of vitamin K1, 0.016 parts of thiamine hydrochloride, 0.008 parts of vitamin B2, 0.080 parts of niacinamide, 0.037 parts of calcium D-pantothenate, 0.018 parts of pyridoxine hydrochloride, 0.028 parts of biotin, 0.023 parts of folic acid, 0.016 parts of cyanocobalamin, 0.838 parts of vitamin C, 4.455 parts of choline bitartrate, 0.559 parts of L-carnitine tartrate, 0.370 parts of taurine, and 1.610 parts of maltodextrin;

[0031] The compound trace minerals are composed of the following ingredients: 0.14 parts of coated copper sulfate, 0.36 parts of ferric pyrophosphate, 0.45 parts of manganese sulfate, 0.06 parts of sodium selenite, 0.17 parts of zinc citrate, 0.02 parts of potassium iodide, and 0.72 parts of maltodextrin;

[0032] The compound macro-minerals are composed of the following ingredients: 10.43 parts of tricalcium phosphate, 7.74 parts of calcium carbonate, 3.83 parts of magnesium carbonate, 7.89 parts of potassium chloride, 7.22 parts of potassium citrate, 6.63 parts of sodium citrate, and 4.92 parts of maltodextrin.

[0033] Furthermore, the nutritional composition can increase serum protein levels, reduce inflammatory factors in serum, increase serum immunoglobulin levels, and increase spleen and thymus indexes.

[0034] The second aspect of the present invention provides a use of the nutritional composition described in the first aspect in the preparation of food, health products or medicines for promoting postoperative tissue repair and metabolic regulation.

[0035] Furthermore, the food, health product or medicine is in the form of powder, tablet, capsule or paste, including but not limited to the dosage forms listed above.

[0036] Beneficial effects of the present invention:

[0037] The present invention provides a nutritional composition, which is fed to postoperative rats for two weeks, and can significantly improve the rats' serum protein levels, reduce inflammatory factors in serum, increase serum immunoglobulin levels, and increase spleen and thymus indexes, thereby effectively promoting wound healing and postoperative recovery in postoperative rats. It can be seen that the present invention, through the scientific ratio of multiple nutrients, can achieve a multi-target regulatory mechanism to promote postoperative wound repair, improve metabolic disorders and enhance immune function in patients, accelerate the recovery process, and reduce the incidence of postoperative complications. It is suitable for nutritional support during the convalescent period after various operations. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 This is a test graph showing serum protein levels in post-operative rats fed with different nutritional compositions for two weeks;

[0039] Figure 2 This is a test graph showing the levels of inflammatory factors in post-operative rats fed with different nutritional compositions for two weeks;

[0040] Figure 3 This is a test graph showing immunoglobulin levels in post-operative rats fed with different nutritional compositions for two weeks;

[0041] Figure 4 The graph shows the organ indexes of postoperative rats fed with different nutritional compositions for two weeks. DETAILED DESCRIPTION

[0042] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which the present invention pertains. The terms used herein in the specification of the present invention are for the purpose of describing specific embodiments only and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the relevant listed items. The term "includes" or "comprising" described in the present invention means that in addition to the components described, it may also include or contain other components. The term "includes" or "comprising" described in the present invention may also be replaced by the closed form "for" or "consisting of..."

[0043] The specific components involved in the following examples and comparative examples can all be purchased or prepared by conventional technical means, and the sources of the same components are all the same. The present invention will be further described below in conjunction with specific examples so that those skilled in the art can better understand the present invention and be able to implement it, but the examples are not intended to limit the present invention.

[0044] Example 1

[0045] This embodiment relates to a nutritional composition, specifically comprising the following ingredients:

[0046] 136.28 parts of maltodextrin, 59.37 parts of solid corn syrup, 153.03 parts of resistant dextrin, 21.16 parts of fructooligosaccharides, 258.28 parts of whey protein peptides, 87.20 parts of sodium caseinate, 51.54 parts of fish oil, 150.28 parts of medium-chain triglycerides, 8.991 parts of complex vitamins, 1.92 parts of complex trace minerals, 48.66 parts of complex macrominerals, and 4.34 parts of vanillin.

[0047] Among them, the complex vitamins: 0.060 parts of vitamin A palmitate, 0.039 parts of vitamin D3, 0.823 parts of dl-α-tocopheryl acetate, 0.011 parts of vitamin K1, 0.016 parts of thiamine hydrochloride, 0.008 parts of vitamin B2, 0.080 parts of niacinamide, 0.037 parts of calcium D-pantothenate, 0.018 parts of pyridoxine hydrochloride, 0.028 parts of biotin, 0.023 parts of folic acid, 0.016 parts of cyanocobalamin, 0.838 parts of vitamin C, 4.455 parts of choline bitartrate, 0.559 parts of L-carnitine tartrate, 0.370 parts of taurine, and 1.610 parts of maltodextrin.

[0048] Compound trace minerals: 0.14 parts of coated copper sulfate (copper sulfate accounts for 35.4% by mass in coated copper sulfate, and the coating material is composed of maltodextrin and citric acid, wherein the mass ratio of maltodextrin to citric acid is 40:1), 0.36 parts of ferric pyrophosphate, 0.45 parts of manganese sulfate, 0.06 parts of sodium selenite, 0.17 parts of zinc citrate, 0.02 parts of potassium iodide, and 0.72 parts of maltodextrin.

[0049] Compound macro minerals: 10.43 parts of tricalcium phosphate, 7.74 parts of calcium carbonate, 3.83 parts of magnesium carbonate, 7.89 parts of potassium chloride, 7.22 parts of potassium citrate, 6.63 parts of sodium citrate, and 4.92 parts of maltodextrin.

[0050] Example 2

[0051] This embodiment relates to a nutritional composition, specifically comprising the following ingredients:

[0052] 167.68 parts of maltodextrin, 40.40 parts of solid corn syrup, 114.96 parts of resistant dextrin, 23.44 parts of fructooligosaccharides, 306.55 parts of whey protein peptides, 148.69 parts of sodium caseinate, 56.33 parts of fish oil, 124.06 parts of medium-chain triglycerides, 8.42 parts of complex vitamins, 1.53 parts of complex trace minerals, 54.51 parts of complex macrominerals, and 2.95 parts of vanillin.

[0053] Among them, the complex vitamins: 0.1 part of vitamin A palmitate, 0.02 parts of vitamin D3, 0.64 parts of dl-α-tocopheryl acetate, 0.01 parts of vitamin K1, 0.01 parts of thiamine hydrochloride, 0.01 parts of vitamin B2, 0.04 parts of niacinamide, 0.03 parts of calcium D-pantothenate, 0.03 parts of pyridoxine hydrochloride, 0.02 parts of biotin, 0.03 parts of folic acid, 0.03 parts of cyanocobalamin, 0.92 parts of vitamin C, 3.05 parts of choline bitartrate, 0.4 parts of L-carnitine tartrate, 0.31 parts of taurine, and 2.77 parts of maltodextrin.

[0054] Compound trace minerals: 0.15 parts of coated copper sulfate, 0.27 parts of ferric pyrophosphate, 0.36 parts of manganese sulfate, 0.09 parts of sodium selenite, 0.1 parts of zinc citrate, 0.03 parts of potassium iodide, and 0.53 parts of maltodextrin.

[0055] Compound macrominerals: 5.03 parts of tricalcium phosphate, 7.05 parts of calcium carbonate, 4.25 parts of magnesium carbonate, 5.05 parts of potassium chloride, 11.82 parts of potassium citrate, 15.99 parts of sodium citrate, and 5.32 parts of maltodextrin.

[0056] Example 3

[0057] This embodiment relates to a nutritional composition, specifically comprising the following ingredients:

[0058] 118.62 parts of maltodextrin, 30.86 parts of solid corn syrup, 57.59 parts of resistant dextrin, 13.27 parts of fructooligosaccharides, 142.32 parts of whey protein peptides, 79.6 parts of sodium caseinate, 29.36 parts of fish oil, 83.46 parts of medium-chain triglycerides, 4.87 parts of complex vitamins, 1.03 parts of complex trace minerals, 39.29 parts of complex macrominerals, and 1.97 parts of vanillin.

[0059] Among them, the vitamin complex: vitamin A palmitate 0.031 parts, vitamin D3 0.016 parts, dl-α-tocopheryl acetate 0.344 parts, vitamin K1 0.003 parts, thiamine hydrochloride 0.01 parts, vitamin B2 0.005 parts, niacinamide 0.037 parts, D-calcium pantothenate 0.019 parts, pyridoxine hydrochloride 0.012 parts, biotin 0.011 parts, folic acid 0.01 parts, cyanocobalamin 0.015 parts, vitamin C 0.331 parts, choline bitartrate 1.493 parts, L-carnitine tartrate 0.187 parts, taurine 0.132 parts, maltodextrin 1.191 parts;

[0060] Compound trace minerals: 0.06 parts of coated copper sulfate, 0.13 parts of ferric pyrophosphate, 0.33 parts of manganese sulfate, 0.05 parts of sodium selenite, 0.08 parts of zinc citrate, 0.02 parts of potassium iodide, and 0.52 parts of maltodextrin;

[0061] Compound macro minerals: 4.93 parts of tricalcium phosphate, 5.83 parts of calcium carbonate, 2.05 parts of magnesium carbonate, 4.05 parts of potassium chloride, 6.12 parts of potassium citrate, 5.93 parts of sodium citrate, and 2.29 parts of maltodextrin.

[0062] Example 4

[0063] This embodiment relates to a nutritional composition, specifically comprising the following ingredients:

[0064] 284.55 parts of maltodextrin, 82.63 parts of solid corn syrup, 161.4 parts of resistant dextrin, 32.16 parts of fructooligosaccharides, 314.6 parts of whey protein peptides, 153.37 parts of sodium caseinate, 70.66 parts of fish oil, 162.94 parts of medium-chain triglycerides, 12.08 parts of complex vitamins, 2.49 parts of complex trace minerals, 93.1 parts of complex macrominerals, and 4.53 parts of vanillin.

[0065] Among them, the vitamin complex: vitamin A palmitate 0.114 parts, vitamin D3 0.048 parts, dl-α-tocopheryl acetate 1.008 parts, vitamin K1 0.011 parts, thiamine hydrochloride 0.022 parts, vitamin B2 0.014 parts, niacinamide 0.117 parts, D-calcium pantothenate 0.049 parts, pyridoxine hydrochloride 0.046 parts, biotin 0.029 parts, folic acid 0.03 parts, cyanocobalamin 0.042 parts, vitamin C 1.074 parts, choline bitartrate 4.948 parts, L-carnitine tartrate 0.653 parts, taurine 0.37 parts, maltodextrin 3.94 parts;

[0066] Compound trace minerals: 0.15 parts of coated copper sulfate, 0.38 parts of ferric pyrophosphate, 0.92 parts of manganese sulfate, 0.09 parts of sodium selenite, 0.2 parts of zinc citrate, 0.04 parts of potassium iodide, and 1.1 parts of maltodextrin.

[0067] Compound macro minerals: 14.29 parts of tricalcium phosphate, 15.14 parts of calcium carbonate, 5.24 parts of magnesium carbonate, 9.88 parts of potassium chloride, 13.36 parts of potassium citrate, 17.19 parts of sodium citrate, and 6.3 parts of maltodextrin.

[0068] Comparative Example 1

[0069] This comparative example relates to a nutritional composition, which differs from Example 1 only in that: 102 parts of whey protein peptide, 18 parts of fish oil, 66 parts of medium-chain triglycerides, and no additive of oligofructose, while the remaining ingredients and mass fractions are the same, and a corresponding nutritional composition is prepared.

[0070] Comparative Example 2

[0071] This comparative example relates to a nutritional composition, which differs from Example 1 only in that: 142 parts of solid corn syrup, 32 parts of resistant dextrin, 51 parts of sodium caseinate, and the compound vitamin does not contain L-carnitine tartrate and taurine. The remaining ingredients and mass fractions are the same, and the corresponding nutritional composition is prepared.

[0072] Comparative Example 3

[0073] This comparative example relates to a nutritional composition, which differs from Example 1 only in that: 88 parts of whey protein peptide, 192 parts of sodium caseinate, 11 parts of fish oil, 77 parts of medium-chain triglycerides, and 2.1 parts of complex vitamins, wherein the complex vitamins specifically include: 0.14 parts of vitamin A palmitate, 0.009 parts of vitamin D3, 0.192 parts of dl-α-tocopheryl acetate, 0.003 parts of vitamin K1, 0.004 parts of thiamine hydrochloride, 0.002 parts of vitamin B2, 0.019 parts of niacinamide, 0.009 parts of calcium D-pantothenate, 0.004 parts of pyridoxine hydrochloride, 0.007 parts of biotin, 0.005 parts of folic acid, 0.004 parts of cyanocobalamin, and 0.01 parts of vitamin C. 0.196 parts, 1.041 parts of choline bitartrate, 0.131 parts of L-carnitine tartrate, 0.086 parts of taurine, 0.376 parts of maltodextrin; the remaining ingredients and mass parts are the same, and the corresponding nutritional composition is prepared.

[0074] Application and biochemical index testing

[0075] (1) The nutritional compositions prepared in the above examples and comparative examples were fed to postoperative rats, specifically as follows:

[0076] Ninety SPF-grade, 8-week-old male Sprague-Dawley rats weighing 240-270 g were used. The animals were housed in a clean, constant temperature and humidity environment (22-25°C, 65%-70% humidity), with a 12-hour light-dark cycle and a well-ventilated environment. Food and water were available ad libitum.

[0077] After one week of adaptive feeding, the rats were randomly divided into 9 groups, each with 10 rats: a blank control group, a model group, Example 1 group, Example 2 group, Example 3 group, Example 4 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group. The rats in the model group, Example 1 group, Example 2 group, Example 3 group, Example 4 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group were subjected to abdominal surgery, partial fat removal, and suture to simulate the surgical procedure.

[0078] Intervention began after surgery. Groups Example 1, Example 2, Example 3, Example 4, Comparative Example 1, Comparative Example 2, and Comparative Example 3 were gavaged with aqueous solutions of the nutritional compositions of Example 1, Example 2, Example 3, Example 4, Comparative Example 1, Comparative Example 2, and Comparative Example 3, respectively, at a dose of 3 g / kg·BW. The blank control group and the model group were gavaged with an equal amount of distilled water daily for two consecutive weeks.

[0079] Two weeks after gavage, all rats were weighed, and blood was collected from the abdominal aorta. Serum was separated and stored. After sacrifice, thymus and spleen tissues were removed, weighed, and weights were recorded. Serum was used for subsequent experimental testing.

[0080] (2) The serum and tissues of the rats fed for one week were tested for the following biochemical indices:

[0081] A. Serum protein level test: Serum albumin (ALB), prealbumin (PA) and total protein (TP) are key biochemical indicators for evaluating postoperative wound healing ability. A decrease in ALB levels can lead to edema and delayed cell proliferation, significantly increasing the risk of infection. PA can sensitively reflect early protein-energy malnutrition, and a decrease in its concentration often indicates insufficient collagen synthesis and excessive metabolic stress. TP comprehensively reflects the body's protein metabolic status. A decrease in its level directly affects the production of collagenase, growth factors and structural proteins, leading to decreased fibroblast activity and weakened wound tensile strength, slowing wound healing. The three can accurately assess nutritional status and repair potential. ALB, PA and TP levels were detected using kits to evaluate the effects of each group of interventions on protein metabolism, wound healing and postoperative recovery in rats.

[0082] The test results are as follows Figure 1 As shown, ALB and PA in the model group were significantly lower than those in the blank control group (P < 0.05), and TP was lower than that in the blank control group, but there was no significant difference (P > 0.05). ALB, PA, and TP levels in Example 1-4 groups were significantly higher than those in the model group (P < 0.05), indicating that the nutritional compositions of Examples 1-4 can significantly improve protein metabolism in rats after surgery, promoting wound healing and postoperative recovery. However, no significant effect was observed in Comparative Example 1-3 groups compared to the model group.

[0083] B. Inflammatory Factor Levels: Serum levels of inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) reflect the level of inflammation in rats. Excessive levels of inflammatory factors can exacerbate oxidative stress and matrix degradation, inhibit epithelial regeneration, and hinder postoperative wound healing. Kits were used to measure the levels of inflammatory factors such as TNF-α, IL-1β, and IL-6 in rat serum to assess the level of inflammation in the rats.

[0084] The test results are as follows Figure 2 As shown in the results, the levels of inflammatory factors in the blank control group were significantly lower than those in the model group (P < 0.05). Except for the IL-6 in the Example 2 group, which was close to that in the model group, the levels of inflammatory factors in the Example 1-4 groups were significantly lower than those in the model group (P < 0.05), and slightly higher than those in the blank control group. The levels of inflammatory factors in the comparative example 1-3 groups were similar to those in the model group and much higher than those in the blank control group. It can be seen that the nutritional composition prepared using Examples 1-4 can significantly reduce the levels of inflammatory factors in the serum of rats after surgery.

[0085] C. Immunoglobulin Level Test: Immunoglobulins such as immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) in serum synergistically promote the repair process during wound healing through multi-level immune defense and regulation. The three work together to maintain the immune balance of the wound microenvironment. IgM and IgG lead to early pathogen clearance, while IgA assists in local immune homeostasis. Abnormal levels can lead to recurrent infections and hinder wound healing. The levels of IgA, IgG, and IgM in rat serum were tested using a kit to assess the immune status of the rats.

[0086] The test results are as follows Figure 3 As shown in the results, the immunoglobulin levels in the model group were significantly lower than those in the blank control group (P < 0.05). The IgA, IgG, and IgM levels in the Example 1-4 groups were higher than those in the blank control group and much higher than those in the model group (P < 0.05). The IgA level in the comparative example 1 group was significantly different from that in the model group (P < 0.05), but much lower than that in the Example 1 group. The immunoglobulin levels in the other comparative example groups were not significantly different from those in the model group (P > 0.05).

[0087] D. Organ Index Test: The spleen and thymus of rats are important immune organs. Their organ index (organ weight mg / body weight g) reflects the strength of the body's immune function to a certain extent. During the postoperative recovery process, changes in the spleen and thymus index can reflect the regulatory state of immune function. The structural and functional changes of the spleen and thymus are also closely related to the regulation of inflammatory factors, the proliferation and differentiation of immune cells, and these factors work together to promote wound healing and postoperative recovery. By calculating the spleen and thymus index, the effect of the nutritional composition on immune function is evaluated, thereby providing a scientific basis for postoperative recovery.

[0088] The test results are as follows Figure 4 As shown in the results, the spleen index of the model group was significantly lower than that of the blank control group (P<0.05), and there was no significant difference in the thymus index (P>0.05). The spleen and thymus organ indices of the Example 1-4 groups were significantly higher than those of the model group (P<0.05), indicating that the nutritional composition of the Example 1-4 groups can significantly enhance the immune function of rats. The nutritional composition of the Comparative Example 1-3 groups had no significant effect on the spleen and thymus organ indices of rats.

[0089] In summary, Examples 1-4 can improve the protein metabolism level of rats, reduce inflammation, and enhance immunity, and the nutritional composition prepared in Example 1 has a better comprehensive effect, which is beneficial to accelerate the recovery speed of rats after surgery and has good application prospects in promoting tissue repair and metabolic regulation in postoperative patients.

[0090] The above-described embodiments are merely preferred examples for the purpose of fully illustrating the present invention, and the scope of protection of the present invention is not limited thereto. Equivalent substitutions or modifications made by those skilled in the art based on the present invention are within the scope of protection of the present invention. The scope of protection of the present invention shall be subject to the claims.

Claims

1. A nutritional composition for promoting postoperative tissue repair and metabolic regulation, characterized in that: It contains the following ingredients in parts by mass: 118.62-284.55 parts of maltodextrin, 30.86-82.63 parts of solid corn syrup, 57.59-161.4 parts of resistant dextrin, 13.27-32.16 parts of oligofructose, 142.32-314.6 parts of whey protein peptides, 79.6-153.37 parts of sodium caseinate, 29.36-70.66 parts of fish oil, 83.46-162.94 parts of medium-chain triglycerides, 4.87-12.08 parts of complex vitamins, and 40.32-95.59 parts of complex minerals.

2. The nutritional composition according to claim 1, characterized in that The compound vitamins include vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, choline bitartrate, L-carnitine tartrate and taurine; The vitamin A includes vitamin A palmitate; The vitamin B includes one or more of thiamine hydrochloride, vitamin B2, niacinamide, D-calcium pantothenate, pyridoxine hydrochloride, biotin, folic acid, and cyanocobalamin; The vitamin D includes vitamin D3; The vitamin E includes dl-α-tocopheryl acetate; The vitamin K includes vitamin K1.

3. The nutritional composition according to claim 2, characterized in that The compound vitamin further comprises maltodextrin; The compound vitamins are composed of the following components in parts by mass: 0.031-0.114 parts of vitamin A palmitate, 0.016-0.048 parts of vitamin D3, 0.344-1.008 parts of dl-α-tocopheryl acetate, 0.003-0.011 parts of vitamin K1, 0.01-0.022 parts of thiamine hydrochloride, 0.005-0.014 parts of vitamin B2, 0.037-0.117 parts of niacinamide, 0.0 19-0.049 parts, pyridoxine hydrochloride 0.012-0.046 parts, biotin 0.011-0.029 parts, folic acid 0.01-0.03 parts, cyanocobalamin 0.015-0.042 parts, vitamin C 0.331-1.074 parts, choline bitartrate 1.493-4.948 parts, L-carnitine tartrate 0.187-0.653 parts, taurine 0.132-0.37 parts, maltodextrin 1.191-3.94 parts.

4. The nutritional composition according to claim 1, characterized in that The compound minerals include compound trace minerals and compound macro minerals; The compound trace minerals include coated copper sulfate, ferric pyrophosphate, manganese sulfate, sodium selenite, zinc citrate and potassium iodide; The compound macro minerals include tricalcium phosphate, calcium carbonate, magnesium carbonate, potassium chloride, potassium citrate and sodium citrate.

5. The nutritional composition according to claim 4, characterized in that The mass ratio of the complex trace minerals to the complex macro minerals in the complex minerals is (1.03-2.49): (39.29-93.1).

6. The nutritional composition according to claim 5, characterized in that The complex trace minerals further comprise maltodextrin; The compound trace minerals are composed of the following components in parts by mass: 0.06-0.15 parts of coated copper sulfate, 0.13-0.38 parts of ferric pyrophosphate, 0.33-0.92 parts of manganese sulfate, 0.05-0.09 parts of sodium selenite, 0.08-0.2 parts of zinc citrate, 0.02-0.04 parts of potassium iodide, and 0.52-1.1 parts of maltodextrin.

7. The nutritional composition according to claim 5, characterized in that The complex macro-minerals further comprise maltodextrin; The compound macro-minerals are composed of the following components in parts by mass: 4.93-14.29 parts of tricalcium phosphate, 5.83-15.14 parts of calcium carbonate, 2.05-5.24 parts of magnesium carbonate, 4.05-9.88 parts of potassium chloride, 6.12-13.36 parts of potassium citrate, 5.93-17.19 parts of sodium citrate, and 2.29-6.3 parts of maltodextrin.

8. The nutritional composition according to claim 1, wherein The nutritional composition further comprises 1.97-4.53 parts of vanillin; The nutritional composition comprises the following ingredients in parts by mass: 118.62-284.55 parts of maltodextrin, 30.86-82.63 parts of solid corn syrup, 57.59-161.4 parts of resistant dextrin, 13.27-32.16 parts of oligofructose, 142.32-314.6 parts of whey protein peptides, 79.6-153.37 parts of sodium caseinate, 29.36-70.66 parts of fish oil, 83.46-162.94 parts of medium-chain triglycerides, 4.87-12.08 parts of complex vitamins, 1.03-2.49 parts of complex trace minerals, 39.29-93.1 parts of complex macrominerals, and 1.97-4.53 parts of vanillin; wherein, in parts by mass, The compound vitamin is composed of the following ingredients: 0.031-0.114 parts of vitamin A palmitate, 0.016-0.048 parts of vitamin D3, 0.344-1.008 parts of dl-α-tocopheryl acetate, 0.003-0.011 parts of vitamin K1, 0.01-0.022 parts of thiamine hydrochloride, 0.005-0.014 parts of vitamin B2, 0.037-0.117 parts of niacinamide, 0.019-0.049 parts of calcium D-pantothenate, 0.012-0.046 parts of pyridoxine hydrochloride, 0.011-0.029 parts of biotin, 0.01-0.03 parts of folic acid, 0.015-0.042 parts of cyanocobalamin, and vitamin C. 0.331-1.074 parts, choline bitartrate 1.493-4.948 parts, L-carnitine tartrate 0.187-0.653 parts, taurine 0.132-0.37 parts, maltodextrin 1.191-3.94 parts; The compound trace minerals are composed of the following ingredients: 0.06-0.15 parts of coated copper sulfate, 0.13-0.38 parts of ferric pyrophosphate, 0.33-0.92 parts of manganese sulfate, 0.05-0.09 parts of sodium selenite, 0.08-0.2 parts of zinc citrate, 0.02-0.04 parts of potassium iodide, and 0.52-1.1 parts of maltodextrin; The compound macro-minerals are composed of the following components: 4.93-14.29 parts of tricalcium phosphate, 5.83-15.14 parts of calcium carbonate, 2.05-5.24 parts of magnesium carbonate, 4.05-9.88 parts of potassium chloride, 6.12-13.36 parts of potassium citrate, 5.93-17.19 parts of sodium citrate, and 2.29-6.3 parts of maltodextrin.

9. The nutritional composition according to claim 8, characterized in that The nutritional composition comprises the following ingredients in parts by mass: 136.28 parts of maltodextrin, 59.37 parts of solid corn syrup, 153.03 parts of resistant dextrin, 21.16 parts of oligofructose, 258.28 parts of whey protein peptides, 87.20 parts of sodium caseinate, 51.54 parts of fish oil, 150.28 parts of medium-chain triglycerides, 8.991 parts of complex vitamins, 1.92 parts of complex trace minerals, 48.66 parts of complex macrominerals, and 4.34 parts of vanillin; wherein, in parts by mass, The compound vitamin is composed of the following ingredients: 0.060 parts of vitamin A palmitate, 0.039 parts of vitamin D3, 0.823 parts of dl-α-tocopheryl acetate, 0.011 parts of vitamin K1, 0.016 parts of thiamine hydrochloride, 0.008 parts of vitamin B2, 0.080 parts of niacinamide, 0.037 parts of calcium D-pantothenate, 0.018 parts of pyridoxine hydrochloride, 0.028 parts of biotin, 0.023 parts of folic acid, 0.016 parts of cyanocobalamin, 0.838 parts of vitamin C, 4.455 parts of choline bitartrate, 0.559 parts of L-carnitine tartrate, 0.370 parts of taurine, and 1.610 parts of maltodextrin; The compound trace minerals are composed of the following ingredients: 0.14 parts of coated copper sulfate, 0.36 parts of ferric pyrophosphate, 0.45 parts of manganese sulfate, 0.06 parts of sodium selenite, 0.17 parts of zinc citrate, 0.02 parts of potassium iodide, and 0.72 parts of maltodextrin; The compound macro-minerals are composed of the following ingredients: 10.43 parts of tricalcium phosphate, 7.74 parts of calcium carbonate, 3.83 parts of magnesium carbonate, 7.89 parts of potassium chloride, 7.22 parts of potassium citrate, 6.63 parts of sodium citrate, and 4.92 parts of maltodextrin.

10. Use of the nutritional composition according to any one of claims 1 to 9 in the preparation of food, health products or medicines for promoting postoperative tissue repair and metabolic regulation.

Images